miRTarBase - #MIRT627073


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pre-miRNA Information
pre-miRNA hsa-mir-6501   
Genomic Coordinates chr21: 33550662 - 33550728
Description Homo sapiens miR-6501 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6501-5p
Sequence 3| AGUUGCCAGGGCUGCCUUUGGU |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
1055619 20 ClinVar
COSM5974214 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs756127353 5 dbSNP
rs764400023 6 dbSNP
rs753967693 8 dbSNP
rs1283296362 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SF3A1   
Synonyms PRP21, PRPF21, SAP114, SF3A120
Description splicing factor 3a subunit 1
Transcript NM_005877   
Expression
Putative miRNA Targets on SF3A1
3'UTR of SF3A1
(miRNA target sites are highlighted)		 
>SF3A1|NM_005877|3'UTR
   1 ACAAGAGGAACCTGCTGTCAAGTCCCTGCCATTTTGCCTCTCCTGTCTCCCACCCCCTGCCCCAGACCCAGGAGCCCCCC
  81 TGAGGCTTTGCCTTGCCTGCATATTTGTTTCGCTCTTACTCAGTTTGGGAATTCAAATTGTCCTGCAGAGGTTCATTCCC
 161 CTGACCCTTTCCCCACATTGGTAAGAGTAGCTGGGTTTTCTAAGCCACTCTCTGGAATCTCTTTGTGTTAGGGTCTCGAT
 241 TTGAGGACATTCATTTCTTCAGCAGCCCATTAGCAACTGAGAGCCCAGGGATGTCCTACAGGATAGTTTCATAGTGACAG
 321 GTGGCACTTGGCTAATAGAATATGGCTGATATTGTCATTAATCATTTTGTACCTTGACATGGGTTGTCTAATAAAACTCG
 401 GACCCTTCTTGTGAAATCAGTTAAATAAGACTTGTCTCGGTCACCTGTGCCCTGTCCAGACTCGAGGCAGTGGTAACACT
 481 GCACAGTGCTATGTGGCTTCTCTTTGAGGATTTTTGGGTTTTGTAACTAAATTCTTGCTGCCCTCATACTTTTTATGTAT
 561 TAGAATCATATTCGTATTGCCCTTTTAAAACATTGGGATCCTCCAAAGGCCTGCCCCATGTATTTAACAGTAATACAGGA
 641 AGCATGGCAGGCACCATGCAAACCAAGGATGGATGGTGCAGTCCCTGTGTCAGTGGGCGGTGGTTTCCTGCTGGCCTGGA
 721 ATCACTCATCACCTGATTGATTGGCTCTGTGGTCCTGGGCAGGTGCCTCATAGGTGTGTGGATATGATGACGTTTCTTTA
 801 AAATGTATGTATTTAACAAATACTTAATTGTATTAAGGTCATGTACCAAGGATTTGATAAAGTTTAAATAATTTACTCTC
 881 TACTTTTATCCATTTTATCCATTTTAACTCATGTAATCCTCATGTGAGTATTCCTGTTTAACACTTGAGTAAACTGAGGC
 961 ACAGAGAACATAAGTTGCATGCCATAGTCACACACTGTGAAAGTGAAAAGAGAATGTGTGCAAAACACGTCACAGTCCTG
1041 GTTTCTGAGTAAAGGCAGGCTGTTATCTTTAGAATCAAGCTATCACAGGGAGATAGGCAATGCTGTGGGTGTTGGAGGAA
1121 GGTGAGAGCCTGTTGCTAACAATTTCCTGGTTTTAAAGCTAAGGCTGATTTTATTGGGAAGATCTCACATGTGTGTGGCC
1201 CCTGAGAGTTCCCAGTGCCTTTTATTTGCAGTCCTTCCATTTGGACCTCCTAGCTGCCCCATCAGGTCATCTCCAGGGCT
1281 CAGAGGGGTGAGACCATTTCCCAAGGTCACAGAACCAGCTCTCTAGTCACCACCCTGCCTCTCCCTCTCACCCAGAGTCA
1361 GTACCAGTTTTATGGCTTTATTACAAACTGCTGGGTCCCTCCCATTTTCAACTTGATTGATGGGATGTCATCCCTTATCC
1441 TGTCTGACATTTGCCTCTGGCCTGGTTGCTAGAAGTTTGCCCCAGGGGCAAGAGTTGAAATTTGGCTTCCTGAGGTGGGC
1521 TTTGTGGTTTGCGTCCCTAAAGTGAGCCCACTACTGGTTGCTTGTCCATGGCCAACACCAGAAATCCCCTGAGCACTACC
1601 TGGGTCTCATTCCAAGAAGGAAGAGGGTCAGGAGACCTGGGGAGTCTCATATTCCAAGTTCTTCTTTCTTTCTGGGAGCA
1681 GTGGGCAGTTCATGGTGTTAGGGCACTCACCCCCACAGACTGGCAAACCCTGCAGGACTTCCGTGGCTGAGGCTGTGACC
1761 GGAGGCCAGGAATGCCGTTGGGTGGATTGTGAGTGAATGGGCCCTTTGAGCTGCCCTCTAGAGAGCAAATCCAGTTTCCT
1841 GGAGCTCCTGAATGAATATCTGTACTGGCTCGCTCAGATGCAGAAGCTCCATTGACCATGAGGCCTTGTGAACATCAGTG
1921 GCCACAGGCCCAGTGTGCTGCTTGGCACTGCACTAGTTTAGGACCTGCAGCATGTAGGTAGCGTCCTAGTGTTTATAATA
2001 CAAAGCTGCTCTGCACAGCTTTTCTGATTCTTCTTGCAATCTCCTGAGGATTATCTGCCCCATTTTTAAAACGAGGTGGA
2081 ATACCCAAGGTCATGTAGCCAGTGAGTGCTCTGGAAAGCCAAAGCAGCTCATCCCTTCCTGGGGACCACACTGCTCTGCT
2161 CCACCAGACCACACTATGAAATAGGAATAAGTGCTCCTGTTGCAGGACTGCTGGGAAAACAGGTGGTGTGGGACTTAAGT
2241 CACCATAATTTTGAAGACTTGCATGCAGAGGGCTCCAGGAATTGTAGACATTAAGGAATTTCACTTTCAGTTCTACCCAC
2321 TACTTAAGTACTTGTCATGTACTCTTAGAGGAGGCCAGTAATGATCAGAACCATTTTACTTTAAAATTAATAATATTGTA
2401 TTAGAGAATATATTAAATGGTTATATTGGGTTATGTTAGGATATATACTTGAATGGAAATACATGTACTATTAGCAATCA
2481 TATTTCATTTATCCCTGTAATTAGACAAGAAAGCATAATATAGCTCTACTCATGGGTACACATACCAGTGTATAAGATTT
2561 TTAGAAGTTTACTTTTTAAAAATAAAAGCAAAATGTAAGATCTTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugguUUCCGUCGGGACCGUUGa 5'
              :||||||   |||:||| 
Target 5' actcGAGGCAG---TGGTAACa 3'
 460 - 478 143.00 -17.20
2 
miRNA  3' ugguuucCGUCGGG--ACCGUUGa 5'
                 |||||||  | ||||| 
Target 5' ttcttcaGCAGCCCATTAGCAACt 3'
 255 - 278 133.00 -18.70
3 
miRNA  3' ugguuuccGUCGGGACCGUUga 5'
                  |||  |||||||  
Target 5' cacccccaCAG-ACTGGCAAac 3'
 1708 - 1728 129.00 -14.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30498258 38 COSMIC
COSN26994427 60 COSMIC
COSN30166210 74 COSMIC
COSN30154654 185 COSMIC
COSN15727197 342 COSMIC
COSN21961327 517 COSMIC
COSN26592707 592 COSMIC
COSN16367857 807 COSMIC
COSN23636124 842 COSMIC
COSN9164014 1383 COSMIC
COSN6423097 1820 COSMIC
COSN19117329 1872 COSMIC
COSN8009755 1957 COSMIC
COSN9164013 2199 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749964922 1 dbSNP
rs1396397107 5 dbSNP
rs201154972 11 dbSNP
rs761786172 12 dbSNP
rs1440077551 14 dbSNP
rs1251818469 19 dbSNP
rs1200256571 22 dbSNP
rs751483682 23 dbSNP
rs1321931449 29 dbSNP
rs763862103 37 dbSNP
rs762810591 38 dbSNP
rs76936529 42 dbSNP
rs770076729 45 dbSNP
rs1322050371 47 dbSNP
rs375301118 51 dbSNP
rs887752848 55 dbSNP
rs1305665080 56 dbSNP
rs1341782275 63 dbSNP
rs1032018193 67 dbSNP
rs1390759797 69 dbSNP
rs1400670314 70 dbSNP
rs751572592 74 dbSNP
rs1269520573 76 dbSNP
rs1002025605 78 dbSNP
rs1467723150 79 dbSNP
rs1213952883 81 dbSNP
rs1417473521 95 dbSNP
rs764012148 97 dbSNP
rs543715750 100 dbSNP
rs905031226 101 dbSNP
rs1161790713 105 dbSNP
rs1040544020 107 dbSNP
rs1231272801 109 dbSNP
rs1328185736 111 dbSNP
rs1046327976 112 dbSNP
rs1381711261 113 dbSNP
rs1013471210 131 dbSNP
rs1319124247 132 dbSNP
rs1438968887 136 dbSNP
rs943501522 139 dbSNP
rs887007230 147 dbSNP
rs1291159473 154 dbSNP
rs556869720 155 dbSNP
rs762775050 165 dbSNP
rs1233448179 166 dbSNP
rs1274658100 171 dbSNP
rs1047508654 180 dbSNP
rs1466838264 194 dbSNP
rs1180849689 199 dbSNP
rs1045784 200 dbSNP
rs1204011178 202 dbSNP
rs775287755 206 dbSNP
rs1228558434 208 dbSNP
rs148941306 210 dbSNP
rs769539684 212 dbSNP
rs1186072414 213 dbSNP
rs1039809437 222 dbSNP
rs1475739165 225 dbSNP
rs1277267774 236 dbSNP
rs759809914 237 dbSNP
rs1453373861 238 dbSNP
rs1238233725 241 dbSNP
rs1387264536 244 dbSNP
rs1411612947 249 dbSNP
rs776661122 252 dbSNP
rs1354814216 253 dbSNP
rs3171603 257 dbSNP
rs543088935 260 dbSNP
rs771104580 263 dbSNP
rs1314730629 266 dbSNP
rs1237914462 276 dbSNP
rs1260751436 279 dbSNP
rs867080914 281 dbSNP
rs1352229888 299 dbSNP
rs924955315 302 dbSNP
rs978191917 314 dbSNP
rs1393494166 317 dbSNP
rs747059189 323 dbSNP
rs986937302 327 dbSNP
rs1190479173 335 dbSNP
rs1248905134 347 dbSNP
rs1418675117 352 dbSNP
rs1160127916 356 dbSNP
rs368115921 374 dbSNP
rs569436772 384 dbSNP
rs917868530 388 dbSNP
rs572563820 400 dbSNP
rs554250167 401 dbSNP
rs988220144 402 dbSNP
rs959162322 404 dbSNP
rs1435307598 411 dbSNP
rs957720027 413 dbSNP
rs1370932718 417 dbSNP
rs538809779 418 dbSNP
rs1032089893 419 dbSNP
rs1307262183 425 dbSNP
rs867676045 431 dbSNP
rs373966755 434 dbSNP
rs145711744 438 dbSNP
rs984854307 439 dbSNP
rs1178207602 440 dbSNP
rs1382747543 443 dbSNP
rs1192345411 449 dbSNP
rs1013382875 456 dbSNP
rs1252910818 457 dbSNP
rs1452860178 458 dbSNP
rs748614878 463 dbSNP
rs1026305815 464 dbSNP
rs1046970430 470 dbSNP
rs1435204102 477 dbSNP
rs1178152377 481 dbSNP
rs901845885 504 dbSNP
rs995953859 505 dbSNP
rs1019581407 515 dbSNP
rs1461288680 534 dbSNP
rs898482369 540 dbSNP
rs1481843738 545 dbSNP
rs1007779236 551 dbSNP
rs1453037355 552 dbSNP
rs1281502462 559 dbSNP
rs889259826 568 dbSNP
rs779448031 570 dbSNP
rs1054576693 573 dbSNP
rs538136146 574 dbSNP
rs552466013 578 dbSNP
rs118168076 585 dbSNP
rs912625376 586 dbSNP
rs1051265775 594 dbSNP
rs1042055530 596 dbSNP
rs946201221 605 dbSNP
rs750103357 620 dbSNP
rs1253488519 621 dbSNP
rs1467278640 626 dbSNP
rs913507878 630 dbSNP
rs990412865 635 dbSNP
rs957965427 641 dbSNP
rs1455642156 644 dbSNP
rs1184922237 651 dbSNP
rs1417274000 653 dbSNP
rs1427892125 654 dbSNP
rs924964438 656 dbSNP
rs1369896033 669 dbSNP
rs1170838253 670 dbSNP
rs1425541323 675 dbSNP
rs547782060 678 dbSNP
rs969112627 687 dbSNP
rs535853257 698 dbSNP
rs1394851375 719 dbSNP
rs992438012 725 dbSNP
rs951246145 726 dbSNP
rs1286660798 735 dbSNP
rs1361830186 744 dbSNP
rs1215701313 745 dbSNP
rs565388563 747 dbSNP
rs780692804 748 dbSNP
rs1298119358 750 dbSNP
rs995425099 752 dbSNP
rs898385237 755 dbSNP
rs1056370811 769 dbSNP
rs937932912 770 dbSNP
rs758378517 776 dbSNP
rs547489305 782 dbSNP
rs1006854413 789 dbSNP
rs865842372 791 dbSNP
rs756858931 792 dbSNP
rs1187056353 807 dbSNP
rs118010891 809 dbSNP
rs972182393 827 dbSNP
rs891943669 840 dbSNP
rs1418097034 841 dbSNP
rs966412918 841 dbSNP
rs1156261387 843 dbSNP
rs1055143282 844 dbSNP
rs2108094 845 dbSNP
rs1018966169 846 dbSNP
rs1007748256 857 dbSNP
rs565075096 862 dbSNP
rs115826798 865 dbSNP
rs1192062045 867 dbSNP
rs1488302842 872 dbSNP
rs927511808 876 dbSNP
rs1287555393 878 dbSNP
rs1300587475 895 dbSNP
rs1208637732 906 dbSNP
rs1354181361 907 dbSNP
rs760433777 910 dbSNP
rs1414535846 917 dbSNP
rs1000361607 920 dbSNP
rs531633627 921 dbSNP
rs775231678 922 dbSNP
rs1222307572 924 dbSNP
rs188022198 928 dbSNP
rs1220779065 935 dbSNP
rs1009335154 939 dbSNP
rs1359649879 947 dbSNP
rs1265232948 959 dbSNP
rs1484679244 962 dbSNP
rs1186920547 963 dbSNP
rs182558122 966 dbSNP
rs1056169468 968 dbSNP
rs1175132749 970 dbSNP
rs1406517737 974 dbSNP
rs1400774306 979 dbSNP
rs991906557 981 dbSNP
rs868547865 982 dbSNP
rs1374149891 983 dbSNP
rs926566066 995 dbSNP
rs763546602 996 dbSNP
rs1342655295 999 dbSNP
rs1342378680 1000 dbSNP
rs1440213962 1000 dbSNP
rs1311207840 1007 dbSNP
rs1049005348 1013 dbSNP
rs1374406846 1014 dbSNP
rs930506288 1014 dbSNP
rs1278337395 1015 dbSNP
rs1210102334 1026 dbSNP
rs1434626107 1028 dbSNP
rs1360295523 1029 dbSNP
rs919084228 1032 dbSNP
rs116412817 1034 dbSNP
rs1419278356 1036 dbSNP
rs1179934012 1037 dbSNP
rs1169441808 1040 dbSNP
rs762910174 1049 dbSNP
rs962621569 1054 dbSNP
rs1264692095 1057 dbSNP
rs1244663696 1063 dbSNP
rs112624788 1065 dbSNP
rs1405066746 1066 dbSNP
rs114359185 1074 dbSNP
rs2839998 1076 dbSNP
rs891129132 1085 dbSNP
rs765031436 1089 dbSNP
rs759241019 1090 dbSNP
rs978972712 1094 dbSNP
rs776981570 1095 dbSNP
rs1054632855 1142 dbSNP
rs371401061 1145 dbSNP
rs1272070776 1150 dbSNP
rs1438000442 1160 dbSNP
rs896204535 1161 dbSNP
rs1219479575 1163 dbSNP
rs376784304 1164 dbSNP
rs556697317 1174 dbSNP
rs947748422 1187 dbSNP
rs56184734 1189 dbSNP
rs1414283629 1190 dbSNP
rs1379856862 1191 dbSNP
rs992207663 1193 dbSNP
rs1380017240 1199 dbSNP
rs929758410 1200 dbSNP
rs918289374 1205 dbSNP
rs1420694803 1208 dbSNP
rs973940503 1215 dbSNP
rs1324137515 1221 dbSNP
rs573953129 1229 dbSNP
rs911179809 1233 dbSNP
rs1441710224 1252 dbSNP
rs760861689 1261 dbSNP
rs1325663439 1265 dbSNP
rs150182853 1272 dbSNP
rs1269320735 1274 dbSNP
rs955387506 1276 dbSNP
rs1465801099 1278 dbSNP
rs1318345746 1279 dbSNP
rs1029676343 1287 dbSNP
rs1220313358 1290 dbSNP
rs897671424 1304 dbSNP
rs535815507 1305 dbSNP
rs773444934 1306 dbSNP
rs1333766820 1316 dbSNP
rs1036167384 1321 dbSNP
rs1010614257 1323 dbSNP
rs911936578 1325 dbSNP
rs772233697 1331 dbSNP
rs374219757 1343 dbSNP
rs1033504296 1345 dbSNP
rs1163292704 1348 dbSNP
rs1422684142 1349 dbSNP
rs1413910064 1351 dbSNP
rs1417385426 1365 dbSNP
rs1462198447 1372 dbSNP
rs1165033837 1380 dbSNP
rs1183460896 1383 dbSNP
rs1000360049 1402 dbSNP
rs906023902 1411 dbSNP
rs1044658967 1418 dbSNP
rs1014475299 1429 dbSNP
rs59653506 1430 dbSNP
rs1401593927 1433 dbSNP
rs1291253856 1434 dbSNP
rs1333656417 1436 dbSNP
rs925940101 1438 dbSNP
rs979444828 1442 dbSNP
rs1347928304 1445 dbSNP
rs1056133041 1451 dbSNP
rs1287354208 1453 dbSNP
rs1459231639 1460 dbSNP
rs1020881260 1480 dbSNP
rs992972716 1490 dbSNP
rs929595449 1493 dbSNP
rs1189887003 1494 dbSNP
rs1362350671 1503 dbSNP
rs1453134124 1509 dbSNP
rs1034801677 1521 dbSNP
rs1361055027 1532 dbSNP
rs918375255 1533 dbSNP
rs1310798279 1535 dbSNP
rs1232922031 1536 dbSNP
rs1314425627 1537 dbSNP
rs1333680699 1538 dbSNP
rs547110926 1539 dbSNP
rs1237669991 1550 dbSNP
rs538704543 1565 dbSNP
rs1038122562 1569 dbSNP
rs1356416074 1571 dbSNP
rs1322344078 1576 dbSNP
rs1001941194 1578 dbSNP
rs904882778 1580 dbSNP
rs571300083 1587 dbSNP
rs1418763173 1589 dbSNP
rs1179293340 1603 dbSNP
rs1222558270 1608 dbSNP
rs995175485 1612 dbSNP
rs1373311906 1615 dbSNP
rs549990006 1620 dbSNP
rs897705740 1622 dbSNP
rs531545414 1624 dbSNP
rs567521319 1633 dbSNP
rs1304423221 1637 dbSNP
rs779501451 1646 dbSNP
rs1332426696 1654 dbSNP
rs1393826951 1655 dbSNP
rs1390489963 1661 dbSNP
rs773990651 1667 dbSNP
rs1378485726 1672 dbSNP
rs1231533064 1673 dbSNP
rs1392767221 1674 dbSNP
rs944593030 1674 dbSNP
rs1313348051 1676 dbSNP
rs1235850982 1685 dbSNP
rs985262451 1687 dbSNP
rs955321348 1689 dbSNP
rs1480404136 1692 dbSNP
rs1323412790 1696 dbSNP
rs5753073 1699 dbSNP
rs12169570 1701 dbSNP
rs1349956421 1706 dbSNP
rs1193148070 1708 dbSNP
rs1424343829 1714 dbSNP
rs749609163 1730 dbSNP
rs527652149 1741 dbSNP
rs1050497642 1742 dbSNP
rs9606717 1743 dbSNP
rs1379655004 1746 dbSNP
rs1179208604 1749 dbSNP
rs1000224841 1760 dbSNP
rs756837348 1761 dbSNP
rs551060860 1764 dbSNP
rs1488967102 1766 dbSNP
rs533465879 1767 dbSNP
rs777270226 1768 dbSNP
rs77926917 1776 dbSNP
rs927426843 1777 dbSNP
rs896075556 1781 dbSNP
rs1260217293 1787 dbSNP
rs752690769 1802 dbSNP
rs969096908 1811 dbSNP
rs1369155716 1820 dbSNP
rs1247396375 1834 dbSNP
rs1303221954 1843 dbSNP
rs1048438177 1844 dbSNP
rs1192862246 1852 dbSNP
rs993886632 1858 dbSNP
rs1477366473 1862 dbSNP
rs1171189648 1865 dbSNP
rs1385865775 1870 dbSNP
rs896795508 1871 dbSNP
rs951928713 1872 dbSNP
rs962009948 1879 dbSNP
rs866925817 1898 dbSNP
rs1008752841 1924 dbSNP
rs1361935492 1939 dbSNP
rs765084985 1947 dbSNP
rs1280530751 1952 dbSNP
rs1353753692 1967 dbSNP
rs890308705 1968 dbSNP
rs1290610868 1974 dbSNP
rs910950196 1976 dbSNP
rs1050189544 1977 dbSNP
rs996226649 1980 dbSNP
rs1049596907 1982 dbSNP
rs933810936 1983 dbSNP
rs754844290 1986 dbSNP
rs562728745 1988 dbSNP
rs1197976339 1990 dbSNP
rs1473990418 2008 dbSNP
rs1180932625 2012 dbSNP
rs781434829 2016 dbSNP
rs1433954726 2027 dbSNP
rs537299666 2034 dbSNP
rs185295318 2039 dbSNP
rs1269689804 2043 dbSNP
rs922585085 2054 dbSNP
rs1156372670 2057 dbSNP
rs913211670 2062 dbSNP
rs1300384578 2072 dbSNP
rs1286837816 2086 dbSNP
rs1374041399 2090 dbSNP
rs1447487649 2091 dbSNP
rs1219433356 2093 dbSNP
rs1346418432 2099 dbSNP
rs989117072 2109 dbSNP
rs555602800 2111 dbSNP
rs1352832916 2115 dbSNP
rs925971214 2125 dbSNP
rs9606716 2130 dbSNP
rs1484566556 2131 dbSNP
rs970116802 2133 dbSNP
rs980231804 2136 dbSNP
rs1237669590 2139 dbSNP
rs751696709 2144 dbSNP
rs1473595703 2147 dbSNP
rs527721939 2152 dbSNP
rs920394574 2156 dbSNP
rs1339192906 2158 dbSNP
rs992988847 2174 dbSNP
rs1298347920 2176 dbSNP
rs1160977792 2178 dbSNP
rs766152156 2182 dbSNP
rs1026589414 2185 dbSNP
rs140401298 2189 dbSNP
rs1171959425 2191 dbSNP
rs553725300 2193 dbSNP
rs1335323859 2196 dbSNP
rs1361072468 2197 dbSNP
rs1330697798 2199 dbSNP
rs961763731 2199 dbSNP
rs1062349 2215 dbSNP
rs10376 2227 dbSNP
rs1168524785 2228 dbSNP
rs560460311 2238 dbSNP
rs1311356898 2246 dbSNP
rs954595950 2263 dbSNP
rs118096913 2270 dbSNP
rs1005188994 2284 dbSNP
rs761969590 2286 dbSNP
rs1201549150 2287 dbSNP
rs1236961888 2289 dbSNP
rs1457817714 2302 dbSNP
rs1180030883 2305 dbSNP
rs34428744 2308 dbSNP
rs556297986 2310 dbSNP
rs1478006852 2318 dbSNP
rs1043176622 2320 dbSNP
rs1374266952 2326 dbSNP
rs1299973540 2341 dbSNP
rs933863710 2352 dbSNP
rs538012300 2353 dbSNP
rs900990575 2360 dbSNP
rs775063691 2377 dbSNP
rs938922138 2379 dbSNP
rs567484463 2390 dbSNP
rs1316984020 2391 dbSNP
rs927488965 2393 dbSNP
rs1275161284 2396 dbSNP
rs1278252962 2400 dbSNP
rs934593766 2403 dbSNP
rs1044664233 2411 dbSNP
rs1257014579 2419 dbSNP
rs1318202822 2420 dbSNP
rs774596404 2439 dbSNP
rs925835405 2444 dbSNP
rs750854523 2446 dbSNP
rs978737553 2451 dbSNP
rs1200211220 2454 dbSNP
rs1249038515 2462 dbSNP
rs182927015 2463 dbSNP
rs190380548 2468 dbSNP
rs1193462097 2470 dbSNP
rs1424562439 2470 dbSNP
rs1279902111 2477 dbSNP
rs1467407641 2481 dbSNP
rs1162815027 2482 dbSNP
rs973197654 2489 dbSNP
rs769013026 2491 dbSNP
rs116961604 2495 dbSNP
rs1404628252 2506 dbSNP
rs940409451 2521 dbSNP
rs1333366559 2529 dbSNP
rs993301220 2531 dbSNP
rs1397885841 2532 dbSNP
rs566702020 2539 dbSNP
rs1277364662 2546 dbSNP
rs960262702 2558 dbSNP
rs1340696938 2564 dbSNP
rs1220103372 2572 dbSNP
rs74278067 2584 dbSNP
rs1404083793 2588 dbSNP
rs1263097008 2589 dbSNP
rs1296297613 2605 dbSNP
rs987059839 2607 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000215793.8 | 3UTR | AUAGCACCAUUGCACUCCAGCCUGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000215793.8 | 3UTR | AUAGCACCAUUGCACUCCAGCCUGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000215793.8 | 3UTR | GAUAGCACCAUUGCACUCCAGCCUGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
167 hsa-miR-6501-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT156859 FAM126B family with sequence similarity 126 member B 2 2
MIRT173355 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT369102 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT442037 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT442829 AZIN1 antizyme inhibitor 1 2 2
MIRT443729 CCND2 cyclin D2 2 2
MIRT453771 NUCB1 nucleobindin 1 2 10
MIRT453875 IFRD1 interferon related developmental regulator 1 2 12
MIRT454229 OSBPL10 oxysterol binding protein like 10 2 11
MIRT458829 RPUSD2 RNA pseudouridylate synthase domain containing 2 2 2
MIRT459898 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 10
MIRT464162 VMP1 vacuole membrane protein 1 2 15
MIRT495411 SMAD2 SMAD family member 2 2 2
MIRT496906 TRIM56 tripartite motif containing 56 2 2
MIRT498653 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 6
MIRT498706 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT499308 ZNF485 zinc finger protein 485 2 6
MIRT499707 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 10
MIRT499755 CIRH1A UTP4, small subunit processome component 2 6
MIRT499827 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT503691 MAVS mitochondrial antiviral signaling protein 2 2
MIRT512418 LAYN layilin 2 4
MIRT516232 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT522554 MCAM melanoma cell adhesion molecule 2 4
MIRT523760 FBXO27 F-box protein 27 2 4
MIRT525107 PRKD2 protein kinase D2 2 2
MIRT525919 KIAA0391 KIAA0391 2 2
MIRT527246 COMMD6 COMM domain containing 6 2 2
MIRT527564 ADCY7 adenylate cyclase 7 2 2
MIRT528764 CD1D CD1d molecule 2 2
MIRT529362 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT529464 ZNF546 zinc finger protein 546 2 2
MIRT530676 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531635 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531909 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532172 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534234 SLC25A16 solute carrier family 25 member 16 2 4
MIRT534561 RRAGD Ras related GTP binding D 2 2
MIRT534971 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536738 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT538544 CELF1 CUGBP Elav-like family member 1 2 2
MIRT540462 ZNF71 zinc finger protein 71 2 2
MIRT540554 PPIC peptidylprolyl isomerase C 2 2
MIRT543593 KIAA1549 KIAA1549 2 2
MIRT543963 RNF20 ring finger protein 20 2 2
MIRT544047 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT544670 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT550665 TRAF1 TNF receptor associated factor 1 2 2
MIRT558540 CSNK1G3 casein kinase 1 gamma 3 2 4
MIRT574917 Vmp1 vacuole membrane protein 1 2 9
MIRT575298 Osbpl10 oxysterol binding protein-like 10 2 7
MIRT607960 SNX22 sorting nexin 22 2 2
MIRT610649 TIPRL TOR signaling pathway regulator 2 8
MIRT615899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT617438 CCS copper chaperone for superoxide dismutase 2 2
MIRT617510 C5orf45 MRN complex interacting protein 2 2
MIRT617548 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT620565 WBSCR27 methyltransferase like 27 2 2
MIRT623166 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624161 DGKE diacylglycerol kinase epsilon 2 2
MIRT626090 MKLN1 muskelin 1 2 2
MIRT627010 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627073 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627136 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627340 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627436 TAS2R5 taste 2 receptor member 5 2 2
MIRT628273 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629091 F2RL1 F2R like trypsin receptor 1 2 4
MIRT629282 UNC13A unc-13 homolog A 2 2
MIRT630122 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630247 SMTNL2 smoothelin like 2 2 2
MIRT631260 CENPM centromere protein M 2 2
MIRT631336 CD300E CD300e molecule 2 2
MIRT631399 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632593 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632991 DUSP18 dual specificity phosphatase 18 2 2
MIRT633079 CXorf21 chromosome X open reading frame 21 2 2
MIRT634223 TMEM132B transmembrane protein 132B 2 2
MIRT635046 MYH11 myosin heavy chain 11 2 2
MIRT636444 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636649 CDK4 cyclin dependent kinase 4 2 2
MIRT637129 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637282 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637527 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637783 OLA1 Obg like ATPase 1 2 2
MIRT637920 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638238 SLC1A5 solute carrier family 1 member 5 2 2
MIRT638444 PLXDC2 plexin domain containing 2 2 2
MIRT639765 GPR45 G protein-coupled receptor 45 2 2
MIRT640437 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT643006 ZNF829 zinc finger protein 829 2 2
MIRT644233 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644661 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644957 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT645086 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645256 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT645861 GBP6 guanylate binding protein family member 6 2 2
MIRT645987 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646502 FAM217B family with sequence similarity 217 member B 2 2
MIRT646811 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT647706 NFX1 nuclear transcription factor, X-box binding 1 2 2
MIRT649657 TEP1 telomerase associated protein 1 2 2
MIRT650550 YIPF4 Yip1 domain family member 4 2 2
MIRT650785 GSR glutathione-disulfide reductase 2 2
MIRT651461 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652098 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT654117 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT658901 DPY19L4 dpy-19 like 4 2 2
MIRT659370 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT662537 MTAP methylthioadenosine phosphorylase 2 2
MIRT662617 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT663491 IYD iodotyrosine deiodinase 2 2
MIRT663899 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT664552 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT664582 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664953 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT665193 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665446 WDR17 WD repeat domain 17 2 2
MIRT665894 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT666480 SBNO1 strawberry notch homolog 1 2 2
MIRT666514 RNF170 ring finger protein 170 2 2
MIRT666692 RBM23 RNA binding motif protein 23 2 2
MIRT666791 PSMD1 proteasome 26S subunit, non-ATPase 1 2 2
MIRT667453 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT667553 LRAT lecithin retinol acyltransferase 2 4
MIRT667744 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668080 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668114 GK5 glycerol kinase 5 (putative) 2 2
MIRT668501 ESYT2 extended synaptotagmin 2 2 2
MIRT668942 CNKSR3 CNKSR family member 3 2 2
MIRT670408 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671134 CD226 CD226 molecule 2 2
MIRT671919 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672287 GP2 glycoprotein 2 2 2
MIRT672427 POLR2D RNA polymerase II subunit D 2 2
MIRT672762 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672923 LRRC2 leucine rich repeat containing 2 2 2
MIRT673150 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673309 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT673560 PLA2G16 phospholipase A2 group XVI 2 2
MIRT673895 DCTN6 dynactin subunit 6 2 2
MIRT674513 PRR23A proline rich 23A 2 2
MIRT674614 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT674747 SLC16A1 solute carrier family 16 member 1 2 2
MIRT675693 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT675890 SNAP29 synaptosome associated protein 29 2 2
MIRT685271 KIAA1143 KIAA1143 2 2
MIRT686057 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT693886 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT695594 TMEM199 transmembrane protein 199 2 2
MIRT696592 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT698041 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT699907 RUNDC1 RUN domain containing 1 2 2
MIRT706608 CYB5B cytochrome b5 type B 2 2
MIRT706628 PNPT1 polyribonucleotide nucleotidyltransferase 1 2 2
MIRT706640 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT706676 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706723 RFK riboflavin kinase 2 2
MIRT706857 MAFF MAF bZIP transcription factor F 2 2
MIRT706891 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706958 FANCC Fanconi anemia complementation group C 2 2
MIRT706976 XPO5 exportin 5 2 2
MIRT707010 RRP36 ribosomal RNA processing 36 2 2
MIRT707028 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707068 MED29 mediator complex subunit 29 2 2
MIRT713253 ZFP30 ZFP30 zinc finger protein 2 2
MIRT719130 NR2F6 nuclear receptor subfamily 2 group F member 6 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6501-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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