miRTarBase - #MIRT627101


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pre-miRNA Information
pre-miRNA hsa-mir-4749   
Genomic Coordinates chr19: 49854591 - 49854651
Description Homo sapiens miR-4749 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4749-3p
Sequence 42| CGCCCCUCCUGCCCCCACAG |61
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN19730808 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147943327 1 dbSNP
rs148982635 2 dbSNP
rs372882504 3 dbSNP
rs200056596 4 dbSNP
rs570340094 5 dbSNP
rs778438436 11 dbSNP
rs748573000 13 dbSNP
rs770230641 14 dbSNP
rs201103722 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PDRG1   
Synonyms C20orf126, PDRG
Description p53 and DNA damage regulated 1
Transcript NM_030815   
Expression
Putative miRNA Targets on PDRG1
3'UTR of PDRG1
(miRNA target sites are highlighted)		 
>PDRG1|NM_030815|3'UTR
   1 GACTCAAGAACCAAGATGGGGGACCAGCAACCCCCCAGGGTCATGGAGGACCCAGGACCCTCCAACCTTGACACCTGTAA
  81 GGACAGGATCTGCCCTGTAAGGGGCCAGCCGTCAGGAATCTGGCCATGAAAACCTCTTTGTAGTGCTTGGCTACTCTGTG
 161 ATGGCAGGAGGGAACCTTCAGCCTGTCTGGCTGCTGGACCTGGACACCAGGGCTCGGTGGACACAAGATCTATTGACGGG
 241 CCTTGGTAGCCACCAGTGGGTGTGTGGGGCAGTGGCTGTGGGGGTGTAAGAATGACTGCAACAGGCACTTCCCAACAATG
 321 GCCTGCTGTTCACATGGACCCTGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGTGGAGTGTCATTCCAGCATTCCTCTCAG
 401 AAGGGAGAGAGGTTTTCAGGCTGGTGCCATGCGATTGGAATAAAGCAGGAGGCTCATGGGTGGTTGCTGAATGAAGAACA
 481 GAATCTTGGTGCTTTGTGGCTCACCACAGCCATCTGTGGGGCAGGCACACACACCTCCCGCCAGCTCCAATTTTGCACTT
 561 TTTCCCTGCTTGATTCCAAGAGTAGGTGCTGCCTAGCAGCCCTTCGTGGCCACTCTTTACTCAGGAGGGCCTTGCAGAGT
 641 CCTGCACCAGGCCTGGGTGAGTGGATGCGCCTCTTACCATATGACACGTGTCAAGATGCCCTTCCGCCCCCTCTGAAAGT
 721 GGGGCCCGGCCAGCACTGCTCGTTACTGTCTGCCTTCAGTGGTCTGAGGTCCCAGTATGAACTGCCGTGAAGTCAAAACT
 801 CTTATGTGTTCATTAAGGGCTCAATAAATGTTAGCTGAATGAATGAATAGCAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacaCCCCCGUCCUCCCCGc 5'
              | ||| :|||||||| 
Target 5' gaagGAGGGAGGGAGGGGCa 3'
 350 - 369 160.00 -27.10
2 
miRNA  3' gaCACCCCCGUCCUCCCcgc 5'
            |||  ||||||||||   
Target 5' ctGTGATGGCAGGAGGGaac 3'
 156 - 175 134.00 -28.10
3 
miRNA  3' gaCACCCCCGUCCUCCCCGc 5'
            ||||| |:  | ||||| 
Target 5' caGTGGGTGT--GTGGGGCa 3'
 254 - 271 126.00 -17.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31781068 9 COSMIC
COSN26988545 31 COSMIC
COSN30479763 33 COSMIC
COSN30172763 59 COSMIC
COSN30157654 87 COSMIC
COSN1869638 92 COSMIC
COSN31602547 242 COSMIC
COSN31591188 249 COSMIC
COSN31569214 259 COSMIC
COSN5968642 326 COSMIC
COSN30543056 485 COSMIC
COSN31489197 637 COSMIC
COSN9125620 841 COSMIC
COSN7089067 1432 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs377211522 1 dbSNP
rs138193548 2 dbSNP
rs758039145 11 dbSNP
rs530218582 16 dbSNP
rs1390576718 17 dbSNP
rs372764382 22 dbSNP
rs573351364 24 dbSNP
rs11558280 27 dbSNP
rs1456670273 30 dbSNP
rs775185931 32 dbSNP
rs752077648 33 dbSNP
rs764376302 34 dbSNP
rs753443507 35 dbSNP
rs766035603 39 dbSNP
rs1240681647 42 dbSNP
rs760287409 44 dbSNP
rs1250322033 45 dbSNP
rs539161721 46 dbSNP
rs1207266605 50 dbSNP
rs959531918 58 dbSNP
rs1272059755 59 dbSNP
rs1348108893 63 dbSNP
rs1033765167 70 dbSNP
rs1211219201 92 dbSNP
rs982166687 94 dbSNP
rs1267473812 103 dbSNP
rs541455102 108 dbSNP
rs888014459 110 dbSNP
rs55697804 111 dbSNP
rs1454215428 121 dbSNP
rs11558281 125 dbSNP
rs1179656834 126 dbSNP
rs1365852986 134 dbSNP
rs1244764523 136 dbSNP
rs566591866 137 dbSNP
rs931949246 138 dbSNP
rs1391685466 149 dbSNP
rs1407204829 154 dbSNP
rs993478295 158 dbSNP
rs745739232 159 dbSNP
rs899116191 167 dbSNP
rs1370243263 172 dbSNP
rs1016174803 173 dbSNP
rs1007812635 178 dbSNP
rs1333723966 180 dbSNP
rs565262947 181 dbSNP
rs543400848 185 dbSNP
rs368274539 187 dbSNP
rs1265709793 192 dbSNP
rs934438394 199 dbSNP
rs976525838 201 dbSNP
rs944807800 210 dbSNP
rs924047291 214 dbSNP
rs1051478612 215 dbSNP
rs578037897 216 dbSNP
rs1253144094 219 dbSNP
rs1417747941 227 dbSNP
rs1181509806 228 dbSNP
rs1327127648 230 dbSNP
rs902929364 232 dbSNP
rs1041390997 234 dbSNP
rs768491129 237 dbSNP
rs189886185 238 dbSNP
rs1394217214 241 dbSNP
rs1390662697 242 dbSNP
rs1021529065 243 dbSNP
rs1341897237 248 dbSNP
rs1231013502 250 dbSNP
rs1292159712 253 dbSNP
rs1317949662 253 dbSNP
rs535995493 258 dbSNP
rs1199951481 259 dbSNP
rs1391235795 263 dbSNP
rs142316038 266 dbSNP
rs1479938094 266 dbSNP
rs115632928 279 dbSNP
rs746586598 280 dbSNP
rs184904319 281 dbSNP
rs201597847 285 dbSNP
rs938195003 287 dbSNP
rs1459873145 297 dbSNP
rs926748979 299 dbSNP
rs1182742866 301 dbSNP
rs982262839 302 dbSNP
rs1002991506 303 dbSNP
rs1478216335 305 dbSNP
rs970825971 312 dbSNP
rs1471991608 313 dbSNP
rs919337978 315 dbSNP
rs537871248 318 dbSNP
rs1371330122 320 dbSNP
rs1461360137 323 dbSNP
rs1303225044 327 dbSNP
rs1376996967 328 dbSNP
rs906932053 330 dbSNP
rs567297606 333 dbSNP
rs538704302 335 dbSNP
rs571200793 336 dbSNP
rs191652632 342 dbSNP
rs1016598962 350 dbSNP
rs537351747 352 dbSNP
rs777393090 353 dbSNP
rs758097183 356 dbSNP
rs1004976743 365 dbSNP
rs113129323 370 dbSNP
rs1306276757 371 dbSNP
rs1291115188 372 dbSNP
rs953228807 375 dbSNP
rs1486878853 377 dbSNP
rs548819545 380 dbSNP
rs188433406 388 dbSNP
rs114626798 399 dbSNP
rs1270586943 402 dbSNP
rs1229494501 405 dbSNP
rs559973251 406 dbSNP
rs1277819337 410 dbSNP
rs1040358974 411 dbSNP
rs1259675159 412 dbSNP
rs1427870976 430 dbSNP
rs547941675 432 dbSNP
rs532638162 433 dbSNP
rs1041412556 435 dbSNP
rs1323068168 439 dbSNP
rs766613845 440 dbSNP
rs142832152 441 dbSNP
rs549295656 446 dbSNP
rs914415822 457 dbSNP
rs141944223 458 dbSNP
rs938304964 462 dbSNP
rs926842482 463 dbSNP
rs1350661666 464 dbSNP
rs116824985 465 dbSNP
rs949523735 472 dbSNP
rs927224861 489 dbSNP
rs919349475 493 dbSNP
rs779724830 494 dbSNP
rs541064478 495 dbSNP
rs750842248 496 dbSNP
rs1323861709 499 dbSNP
rs531511915 500 dbSNP
rs560821063 501 dbSNP
rs768145588 502 dbSNP
rs1191823444 504 dbSNP
rs986526170 512 dbSNP
rs1452498988 515 dbSNP
rs953321344 519 dbSNP
rs1004589150 527 dbSNP
rs761981996 530 dbSNP
rs542497949 534 dbSNP
rs1344212485 538 dbSNP
rs571937226 539 dbSNP
rs553546468 540 dbSNP
rs967142791 545 dbSNP
rs544814593 546 dbSNP
rs1250244355 550 dbSNP
rs1020469101 551 dbSNP
rs376265506 558 dbSNP
rs1282315275 566 dbSNP
rs1225800254 567 dbSNP
rs1011294712 572 dbSNP
rs6121291 585 dbSNP
rs1305191423 603 dbSNP
rs1316543932 604 dbSNP
rs892862637 605 dbSNP
rs148529008 606 dbSNP
rs1275060699 609 dbSNP
rs1467095869 613 dbSNP
rs41293122 615 dbSNP
rs775799411 618 dbSNP
rs1238598369 619 dbSNP
rs1471065443 625 dbSNP
rs1232317665 629 dbSNP
rs1008876763 632 dbSNP
rs1320959439 642 dbSNP
rs902519758 645 dbSNP
rs1042462748 656 dbSNP
rs1343364372 657 dbSNP
rs905476954 660 dbSNP
rs1336015252 662 dbSNP
rs946774716 663 dbSNP
rs1046650900 668 dbSNP
rs949533776 669 dbSNP
rs1444889238 673 dbSNP
rs1278144231 675 dbSNP
rs1372881036 677 dbSNP
rs145786583 687 dbSNP
rs927202296 688 dbSNP
rs981781426 690 dbSNP
rs970995609 697 dbSNP
rs1036869031 703 dbSNP
rs570381577 704 dbSNP
rs183760918 705 dbSNP
rs372699971 706 dbSNP
rs536926094 707 dbSNP
rs983121781 716 dbSNP
rs369848496 720 dbSNP
rs1483384892 725 dbSNP
rs1027848763 727 dbSNP
rs566325820 728 dbSNP
rs1170759625 732 dbSNP
rs547962973 739 dbSNP
rs923191787 741 dbSNP
rs115501738 742 dbSNP
rs1443106272 745 dbSNP
rs1415663228 747 dbSNP
rs967195600 748 dbSNP
rs116251021 753 dbSNP
rs551680628 757 dbSNP
rs1270775283 761 dbSNP
rs1344569750 779 dbSNP
rs1212683185 781 dbSNP
rs957182592 785 dbSNP
rs745680195 786 dbSNP
rs367755650 787 dbSNP
rs757044856 794 dbSNP
rs1359532630 796 dbSNP
rs1285903183 804 dbSNP
rs751420513 804 dbSNP
rs143367366 805 dbSNP
rs560925639 808 dbSNP
rs1166627254 810 dbSNP
rs1020964287 811 dbSNP
rs1358111492 812 dbSNP
rs542559175 815 dbSNP
rs1310519174 817 dbSNP
rs1431310391 830 dbSNP
rs527570770 838 dbSNP
rs1010934115 844 dbSNP
rs770911462 845 dbSNP
rs6121290 857 dbSNP
rs1319087772 862 dbSNP
rs1167509868 866 dbSNP
rs893882026 866 dbSNP
rs779091944 869 dbSNP
rs1236304808 882 dbSNP
rs746502425 897 dbSNP
rs139924671 898 dbSNP
rs777306936 899 dbSNP
rs6061046 901 dbSNP
rs949970187 908 dbSNP
rs1285787923 913 dbSNP
rs907823301 918 dbSNP
rs370747219 921 dbSNP
rs577683457 922 dbSNP
rs1455032052 925 dbSNP
rs1195907802 951 dbSNP
rs766508039 961 dbSNP
rs983067930 966 dbSNP
rs747706478 967 dbSNP
rs932000128 968 dbSNP
rs923244186 971 dbSNP
rs976040745 972 dbSNP
rs945989141 979 dbSNP
rs778645409 980 dbSNP
rs1395132926 988 dbSNP
rs992774802 997 dbSNP
rs913136466 1000 dbSNP
rs1204030574 1003 dbSNP
rs974901521 1008 dbSNP
rs1301011385 1011 dbSNP
rs1305578449 1012 dbSNP
rs1239468488 1016 dbSNP
rs756370085 1017 dbSNP
rs1348088178 1018 dbSNP
rs761042903 1018 dbSNP
rs1273200429 1019 dbSNP
rs1228868437 1035 dbSNP
rs1469320824 1039 dbSNP
rs556187571 1043 dbSNP
rs543959797 1045 dbSNP
rs1251643071 1050 dbSNP
rs34089906 1057 dbSNP
rs1034105567 1060 dbSNP
rs1182964282 1062 dbSNP
rs1167985892 1067 dbSNP
rs1468737788 1075 dbSNP
rs1158539362 1076 dbSNP
rs1395249737 1076 dbSNP
rs1462978929 1077 dbSNP
rs573711198 1077 dbSNP
rs1350517341 1083 dbSNP
rs1021245572 1089 dbSNP
rs1010881669 1095 dbSNP
rs555400395 1102 dbSNP
rs1237816243 1103 dbSNP
rs1293405422 1110 dbSNP
rs1336357081 1114 dbSNP
rs1230900036 1118 dbSNP
rs1460125227 1122 dbSNP
rs114986928 1123 dbSNP
rs566337942 1126 dbSNP
rs1024006947 1138 dbSNP
rs1002704865 1147 dbSNP
rs554077096 1150 dbSNP
rs906650012 1157 dbSNP
rs1181690988 1161 dbSNP
rs114350216 1162 dbSNP
rs1476239293 1164 dbSNP
rs192600038 1166 dbSNP
rs1367819956 1168 dbSNP
rs550276737 1169 dbSNP
rs1169483042 1176 dbSNP
rs531688870 1183 dbSNP
rs1408952548 1192 dbSNP
rs1252575121 1198 dbSNP
rs567361701 1207 dbSNP
rs1292127188 1210 dbSNP
rs1176877233 1213 dbSNP
rs1479767289 1214 dbSNP
rs962363782 1223 dbSNP
rs1228765339 1231 dbSNP
rs750870356 1235 dbSNP
rs1047657748 1236 dbSNP
rs1015585958 1240 dbSNP
rs1337887793 1242 dbSNP
rs930273531 1246 dbSNP
rs1006399818 1249 dbSNP
rs887917125 1260 dbSNP
rs920264261 1263 dbSNP
rs1486735953 1267 dbSNP
rs1185977685 1277 dbSNP
rs376361287 1278 dbSNP
rs1255535970 1279 dbSNP
rs1248300486 1281 dbSNP
rs750923667 1282 dbSNP
rs1333796061 1283 dbSNP
rs1271221160 1287 dbSNP
rs1371221935 1289 dbSNP
rs1428887640 1290 dbSNP
rs1173960859 1294 dbSNP
rs188983745 1297 dbSNP
rs911668180 1301 dbSNP
rs987623978 1304 dbSNP
rs1301804002 1308 dbSNP
rs1361997456 1308 dbSNP
rs966880799 1310 dbSNP
rs996243241 1310 dbSNP
rs185418189 1312 dbSNP
rs989732308 1315 dbSNP
rs193175077 1316 dbSNP
rs551300380 1319 dbSNP
rs1208965226 1322 dbSNP
rs913154845 1327 dbSNP
rs1255590955 1328 dbSNP
rs1054741350 1332 dbSNP
rs1259581743 1340 dbSNP
rs935868045 1344 dbSNP
rs1293689869 1346 dbSNP
rs1396637809 1347 dbSNP
rs533189360 1347 dbSNP
rs979920247 1348 dbSNP
rs188187497 1351 dbSNP
rs182558347 1354 dbSNP
rs1286539140 1366 dbSNP
rs1387173934 1370 dbSNP
rs1163435214 1379 dbSNP
rs917002046 1381 dbSNP
rs1304684952 1382 dbSNP
rs886276902 1386 dbSNP
rs1217787117 1389 dbSNP
rs1459255097 1397 dbSNP
rs866760743 1407 dbSNP
rs1412853273 1409 dbSNP
rs1218122208 1410 dbSNP
rs1047605554 1412 dbSNP
rs1464426521 1414 dbSNP
rs994705697 1415 dbSNP
rs899121884 1420 dbSNP
rs1452363769 1424 dbSNP
rs1039090867 1443 dbSNP
rs1408267142 1445 dbSNP
rs762266024 1449 dbSNP
rs943078374 1450 dbSNP
rs1410549229 1463 dbSNP
rs11697022 1465 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacaCCCCCGUCCUCCCcgc 5'
              | ||| :||||||   
Target 5' -aagGAGGGAGGGAGGG--- 3'
 		1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_030815 | 3UTR | AGGCACUUCCCAACAAUGGCCUGCUGUUCACAUGGACCCUGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_030815 | 3UTR | AGGCACUUCCCAACAAUGGCCUGCUGUUCACAUGGACCCUGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_030815 | 3UTR | CAACAAUGGCCUGCUGUUCACAUGGACCCUGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_030815 | 3UTR | UUCCCAACAAUGGCCUGCUGUUCACAUGGACCCUGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_030815 | 3UTR | UUCCCAACAAUGGCCUGCUGUUCACAUGGACCCUGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_030815 | 3UTR | UCCCAACAAUGGCCUGCUGUUCACAUGGACCCUGAGCAAGGAAGGAGGGAGGGAGGGGCAGAGUGGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000202017.4 | 3UTR | AAGGAGGGAGGGAGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-4749-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082256 MED29 mediator complex subunit 29 2 4
MIRT112161 OTUD3 OTU deubiquitinase 3 2 2
MIRT150036 MIDN midnolin 2 2
MIRT246308 HIST2H2AA3 histone cluster 2 H2A family member a3 2 4
MIRT246320 HIST2H2AA4 histone cluster 2 H2A family member a4 2 4
MIRT248254 SP1 Sp1 transcription factor 2 2
MIRT257944 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT466973 STARD7 StAR related lipid transfer domain containing 7 2 4
MIRT492322 SETD1B SET domain containing 1B 2 2
MIRT496204 EFCAB1 EF-hand calcium binding domain 1 2 2
MIRT497568 CCR6 C-C motif chemokine receptor 6 2 2
MIRT502990 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT508300 SIX5 SIX homeobox 5 2 4
MIRT522472 ZAK mitogen-activated protein kinase kinase kinase 20 2 2
MIRT525825 VIMP selenoprotein S 2 4
MIRT528154 BCL2L1 BCL2 like 1 2 2
MIRT532606 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT551302 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT568777 FAM53C family with sequence similarity 53 member C 2 6
MIRT570896 METTL21A methyltransferase like 21A 2 2
MIRT570963 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571167 ZNF85 zinc finger protein 85 2 2
MIRT576751 Tmem127 transmembrane protein 127 2 2
MIRT609854 DAZAP2 DAZ associated protein 2 2 2
MIRT627101 PDRG1 p53 and DNA damage regulated 1 2 2
MIRT637060 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT639423 PKP1 plakophilin 1 2 2
MIRT643208 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT646251 PRSS38 protease, serine 38 2 2
MIRT647145 CYP27C1 cytochrome P450 family 27 subfamily C member 1 2 2
MIRT647429 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT650666 GAPDHP44 glyceraldehyde 3 phosphate dehydrogenase pseudogene 44 2 2
MIRT651816 USP49 ubiquitin specific peptidase 49 2 2
MIRT657376 HMGA1 high mobility group AT-hook 1 2 2
MIRT658105 FOXK1 forkhead box K1 2 2
MIRT658161 FCHSD1 FCH and double SH3 domains 1 2 2
MIRT662754 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667209 NIPAL1 NIPA like domain containing 1 2 2
MIRT687003 RPL35 ribosomal protein L35 2 2
MIRT707057 NACC2 NACC family member 2 2 2
MIRT709048 MRO maestro 2 2
MIRT709054 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 2
MIRT709446 VWA2 von Willebrand factor A domain containing 2 2 2
MIRT709847 SNX12 sorting nexin 12 2 2
MIRT710790 IFNLR1 interferon lambda receptor 1 2 2
MIRT711696 GMPR guanosine monophosphate reductase 2 2
MIRT712462 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT713884 MOB3A MOB kinase activator 3A 2 2
MIRT715329 NTN1 netrin 1 2 2
MIRT715927 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT716533 ATF5 activating transcription factor 5 2 2
MIRT716937 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT717007 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT719139 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT720853 MEF2D myocyte enhancer factor 2D 2 2
MIRT721484 LTB4R2 leukotriene B4 receptor 2 2 2
MIRT721517 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT722895 LRRC20 leucine rich repeat containing 20 2 2
MIRT723066 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723086 INSIG1 insulin induced gene 1 2 2
MIRT723353 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT723483 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT724576 NOTCH2 notch 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4749 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4749 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4749-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4749-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-4749-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)

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