miRTarBase - #MIRT628260


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pre-miRNA Information
pre-miRNA hsa-mir-4703   
Genomic Coordinates chr13: 51552589 - 51552667
Description Homo sapiens miR-4703 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4703-3p
Sequence 49| UGUAGUUGUAUUGUAUUGCCAC |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1460841833 5 dbSNP
rs775733304 5 dbSNP
rs756076492 10 dbSNP
rs1378936855 11 dbSNP
rs1049480258 12 dbSNP
rs555347919 13 dbSNP
rs1343138432 18 dbSNP
rs1011011214 19 dbSNP
rs1008216326 21 dbSNP
rs1238676458 22 dbSNP
Putative Targets

Gene Information
Gene Symbol EFCAB14   
Synonyms KIAA0494
Description EF-hand calcium binding domain 14
Transcript NM_014774   
Expression
Putative miRNA Targets on EFCAB14
3'UTR of EFCAB14
(miRNA target sites are highlighted)		 
>EFCAB14|NM_014774|3'UTR
   1 CTTCATCAGGCATATTTTAGAAATGGACTGCCTAATATCTATTTACCTAACAACAAAACAACCCTTACTTACCCATCAGT
  81 CCTCTAGTCCTCCAAACTACTGTAGCAGATACTTTGCCACCTTTTAACTTGTTTGAAGAAGCTATATAAAAGTTATTTTT
 161 TTAAAGAAGAAGACCATTTTACTTATGATGTTCAGAAATCTATGATTTCCTACAACCAGTAAGATCTTACATTTTAAAAT
 241 TGCCAGAAAAAAAATTAAAGCCCTCTTTTTTTCTCTTTCCTTTTTTTGAGGGGAGGAGACCTTATCTTTTAAAGCTGGGA
 321 AATGTATATAGAGAGAGAATAAGCCACTTTTATATTTCACTTAAATTTGCCTTAAATTAGCTGCACTTTATAGAGACTCA
 401 GAAAATGTCTTTTCTTTAAAAGATAGGCCTTTTCTGTTTGTAAATATTTAAATGAAAGAAAGCATTGTGCATATTGTGTG
 481 GAAAGTAGGAAGAATGGTTTTGAACAGGATATGAACAAATGACTTATTAAAAATTGCTGATCTGGTGTAGGTGGCAGCTG
 561 AAACTACATCCATGTCTCCATAAGGTATCCCTCAAAGGCCCAGGCGCTGCCAGGGGGTTTGTCCTGGTAGCTGGAGGAAC
 641 CGATTTCAGGGAGTAGACACTGGAGACAATACTGACTCCAGGCATGGCTCATGGAAGTAGGATTCTGGTTCTTTGTTCCT
 721 ATTCCCTCAGCTAATCCCAACCTGGGAATCAGAGAAGTCTTGGGGATTTTTCTCATTTTTAGTACTATTTCAGGGTTTAT
 801 GAGCATAAAAAGTTATCCATTGGGGAGCTCCATTTTCCCTGCTGAGTGAGCTAGATTGCCTTCCCCACCCACCCACTTAA
 881 GTCTGTCTTAAAGCCGTAGCTGGCTCCCACCACCAGTACCATCTCCATTTGAATGGCAGGGCTAAATTCCCCCAGCCATT
 961 ATCTCACACTGACCACCCAGAGCTTTAGAAGAGAGCTGTGCTTCTAATTTTGACCCAGAAAACCATACCCCTTGAGATTT
1041 TACCTAGAGGCTAACCAAGAGCCTAATATGTTTCTCTGGGGGATGACTAAAGCCAAAAAGGCTGTGAGATGAAACATGTG
1121 AAATAATATTCAGTTTCCTTACCATTACCAGCTCAGAAGTAGCTAGAGGCTTTCTACCCAAAGGATGCCAAAGTATAGCA
1201 GGGCAGGCCTGGAGCTAGGGCCTTCACATGGTGGTAGCAAGTTTTTCAAATCTAATACAATCAAGTACAATACTTCCTTT
1281 AAATGCTTCTGTGGACCTGGCATGAAAGATCCCTAGATTGAAAGGAATAATACCTCCATGTCTCCTGTATGTTGAGTCTA
1361 GAATTGCTGTGTTGTTCTTAGAAGCAGTCTTTGGGCAACAACTTGAAAGGGGAAAAAAAAACTACAAAAACTTAACTTTG
1441 GTATAGGCCAAGTCAGGGAGAAAGTAGAGAAAGCTGTCATGCCACAGACTTCTTTAGTGGAGATCATTTCCTTTTTAACT
1521 TTGTTCAGGTTGCCCTTCACCATGGATACAGTCCGGTACCCTTAAACATTTAAGGGCTGTTTTTTTTTTCTTTACATGAT
1601 GTTCAGCTTGGTATTAACCAAACTTAAATTTTTTTTCCAGAAGTATTAAAATTTAGTTAAAGCAAGATGAAGTCTTTTCC
1681 CATGAATGTGTCCCCTTATCTCATTATAGCTTATGCTCAGTTTCACTTTCTTGGAAAGGTTAAAACAAATTAGCCTGGCA
1761 CTTTAGGTAACTTGAAAATAACTCTCACCCTTCTGACTGCCTTCCATCCACTCTCACCCCACACCTTTTTTTAATATATA
1841 TACACCCTTACAGATTTTCTAACAACCAAATAAAATTCTAGCAATAAATTGAATTATACTGCTATATTTGTATATACTGT
1921 ACCATAAATAGTATGTCTGTACCTGGAAGGTATTTTTTTGAGAACTGATTTATATGAAATATACTTGAGGGTAATGTAGC
2001 TTGTCCTTTTTAGTTTCAAATTCTTATTCATAGGCAGATACTTTGAAGACACCTTAACTCTTTGTTGTGTGTATTTTCCC
2081 TTGCATCAGATAACTATACATGGAGAAATCCATTTTGTTTTTTGGTTTATCTTCTGTTCTTCCTACCTTGTGCTTGTCTG
2161 ACTAGTATCACCCCTGAGCCAGTATACAGTACCATCCTCTCCCCCTACCAAGTTTGGCAGAGGTGTTTATACTGCATTCT
2241 CAGATCTATGAATATTTTTGTCATCCTGCCTGAGAAAGTACATCTTCCAGGCAAAAGTAGGGTATCTTGAACTCCTTTCT
2321 TCTGAGTTGAGCAGACTCACTGGCTTAAGCATCCCATAAGCCTATTATTTAGTGTGAATTTGGGACTTTTATTTGTATGT
2401 TGTCTTAACTTACTAAGCCTGTGACTTGTATTTAGCTGTAGTCAAGCCTCACCAGCCATATCTCATCTCTGAGAGGAAGA
2481 CTGGATAGTGAGTTTGGTTTTGGTTTTGGTTTTAAACCCTTTTACCTTTTCAGTCTGGCAGCTCCTACTGCTGCTTTCCT
2561 AAGTTACTCAAAGCACTGCTTCTTGGTCCTTGTTTTCTTTTGCCTTGTACTATCTTGTATAATGTTTACTAAAAGAGCCT
2641 CCCCATAAATCAGAGAGGCAAAAAGGTAGCATATAAAAAGAAGAACCAAAAGAAGAGAAAACCTGACTTCTAGATGACTG
2721 TGGTGTCATCTAAAAGGCAGAGGTGCCTGACCCTCAGGAATGTGTATGATGCAACAGAGCTGAAGAATGGGTTCCCTTCA
2801 CCTACTGCTGGCCATTGTCCCTTCTGTTGGAGATTCCTTTCTTTATGGTTGCTGTTCATAACCCCTTCAACACCCCCCCT
2881 TGCTGGTCCTGCCGGTCACAGTTGAGGATTTTGGCTGTGATGGGCTCATACTCATAATGGCCTGTTGAGTTGTTTTTAGT
2961 GACAGGTTTTGTTTGCTGCACACCTCATTGGCTTGCTTACCAACACCAGCTAGAAGTGGTCCCTCTTTCATATCCAAACC
3041 AGAACACATTTGGGTATTCCTGAGACTTTATAGAGCGTGTATTGTTTGTTATACGAACCTAACCTACCTTGTTGTTTTCT
3121 CATATTAAGAAATTTAAATCTACTTTGTTTTAGTGAAGCTATTTTGGTAATGTATAAGCAATTTTGGTTCTGTTTAGGGA
3201 GAATTCAGGGTTTCCATGACTTGATTTGAGCTTTGCATATTTCAAATAAGTAACACAGCCATTTTAATTTAGCTAAATAA
3281 AAAAATTTCTTTTTTCTCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caccGUUAUGUUAUGUUGAUGu 5'
              :|||||||| ||| ||| 
Target 5' aatcTAATACAAT-CAAGTACa 3'
 1249 - 1269 141.00 -13.10
2 
miRNA  3' caCCGUUAUGUUAUGUUGAUGu 5'
            || || | ||   |||||| 
Target 5' agGGGAAAAAAA---AACTACa 3'
 1408 - 1426 128.00 -8.02
3 
miRNA  3' caccguuAUGU--UAUGUUGAUGu 5'
                 |:||  | |:|||||: 
Target 5' tttccctTGCATCAGATAACTATa 3'
 2075 - 2098 121.00 -9.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30501885 8 COSMIC
COSN31523214 37 COSMIC
COSN30104132 48 COSMIC
COSN8862327 50 COSMIC
COSN30472374 64 COSMIC
COSN15662385 93 COSMIC
COSN30114852 138 COSMIC
COSN30171029 169 COSMIC
COSN31555652 331 COSMIC
COSN31534628 428 COSMIC
COSN8471374 488 COSMIC
COSN28660368 586 COSMIC
COSN15723610 1066 COSMIC
COSN31578936 1412 COSMIC
COSN31483660 1460 COSMIC
COSN20094810 1579 COSMIC
COSN6403248 1590 COSMIC
COSN31521814 1628 COSMIC
COSN1105009 1768 COSMIC
COSN7991765 1813 COSMIC
COSN31572391 1825 COSMIC
COSN30165152 1958 COSMIC
COSN29968494 1977 COSMIC
COSN4750566 2077 COSMIC
COSN1105007 2451 COSMIC
COSN1446837 2562 COSMIC
COSN29884852 2937 COSMIC
COSN31556151 3095 COSMIC
COSN31537884 3259 COSMIC
COSN31597448 3259 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs377486606 1 dbSNP
rs772854184 8 dbSNP
rs1411758538 11 dbSNP
rs771619127 12 dbSNP
rs1372036868 18 dbSNP
rs144272863 19 dbSNP
rs1430879136 20 dbSNP
rs1265632709 21 dbSNP
rs1340519567 26 dbSNP
rs371756948 29 dbSNP
rs770370922 30 dbSNP
rs775553417 38 dbSNP
rs1197031976 39 dbSNP
rs781747690 41 dbSNP
rs771438407 48 dbSNP
rs9094 50 dbSNP
rs1480553643 57 dbSNP
rs1230707704 63 dbSNP
rs543904326 73 dbSNP
rs1212341420 75 dbSNP
rs1197179965 91 dbSNP
rs746146972 95 dbSNP
rs1422707930 104 dbSNP
rs1188192792 106 dbSNP
rs1370080911 138 dbSNP
rs1009654110 142 dbSNP
rs149566783 145 dbSNP
rs116661609 148 dbSNP
rs1431903047 155 dbSNP
rs757611492 163 dbSNP
rs1053486131 168 dbSNP
rs1355602172 172 dbSNP
rs1307363261 174 dbSNP
rs1007286739 175 dbSNP
rs1228292506 176 dbSNP
rs1371033200 177 dbSNP
rs1304493580 183 dbSNP
rs747422448 185 dbSNP
rs539245662 186 dbSNP
rs1253834819 204 dbSNP
rs1482663317 210 dbSNP
rs1056477505 213 dbSNP
rs1200467462 215 dbSNP
rs565672109 221 dbSNP
rs1463535916 223 dbSNP
rs919176456 224 dbSNP
rs114661493 230 dbSNP
rs1365918493 240 dbSNP
rs1160237640 242 dbSNP
rs1451041103 242 dbSNP
rs1174256050 255 dbSNP
rs942029938 255 dbSNP
rs139271756 270 dbSNP
rs1043760539 272 dbSNP
rs1386537862 273 dbSNP
rs1419025058 274 dbSNP
rs909237368 276 dbSNP
rs1321786804 281 dbSNP
rs1367823791 288 dbSNP
rs1190692710 306 dbSNP
rs1298751635 307 dbSNP
rs1311195120 307 dbSNP
rs191567192 318 dbSNP
rs549326414 324 dbSNP
rs921810062 329 dbSNP
rs777957825 331 dbSNP
rs1326432169 339 dbSNP
rs974978290 342 dbSNP
rs1261121089 355 dbSNP
rs1238129947 364 dbSNP
rs758945446 379 dbSNP
rs753194304 381 dbSNP
rs538127987 384 dbSNP
rs1266392170 387 dbSNP
rs1434049020 389 dbSNP
rs1458998815 416 dbSNP
rs1201821481 424 dbSNP
rs1409913457 427 dbSNP
rs570453418 435 dbSNP
rs1456729765 439 dbSNP
rs1233807019 453 dbSNP
rs1160595739 457 dbSNP
rs374663173 461 dbSNP
rs911764039 468 dbSNP
rs1312276824 473 dbSNP
rs983117979 475 dbSNP
rs990393342 478 dbSNP
rs1368749726 480 dbSNP
rs1413202350 489 dbSNP
rs186924670 502 dbSNP
rs182316786 504 dbSNP
rs1289644230 546 dbSNP
rs533350403 547 dbSNP
rs1268706114 548 dbSNP
rs1343793265 549 dbSNP
rs1219273364 551 dbSNP
rs371598133 562 dbSNP
rs74850214 568 dbSNP
rs1007172416 572 dbSNP
rs1475782993 573 dbSNP
rs1225036511 574 dbSNP
rs969793616 582 dbSNP
rs754527008 584 dbSNP
rs13417 586 dbSNP
rs1410240612 594 dbSNP
rs1262047461 598 dbSNP
rs147451962 599 dbSNP
rs1350852155 604 dbSNP
rs1036587772 605 dbSNP
rs61782562 606 dbSNP
rs1368255475 610 dbSNP
rs1408823117 614 dbSNP
rs1484802958 615 dbSNP
rs562065438 621 dbSNP
rs1226585840 629 dbSNP
rs887688980 632 dbSNP
rs999498564 636 dbSNP
rs543449811 641 dbSNP
rs1043690850 642 dbSNP
rs1482886823 646 dbSNP
rs1206137957 649 dbSNP
rs1234718981 652 dbSNP
rs1048351 653 dbSNP
rs1181817558 655 dbSNP
rs900577213 657 dbSNP
rs189682273 658 dbSNP
rs1446831748 659 dbSNP
rs946223641 669 dbSNP
rs1389936861 670 dbSNP
rs539110544 675 dbSNP
rs1428749975 678 dbSNP
rs1329090966 683 dbSNP
rs913422953 687 dbSNP
rs944498606 694 dbSNP
rs911826632 699 dbSNP
rs957650812 706 dbSNP
rs1248066752 707 dbSNP
rs1295217968 709 dbSNP
rs1341162595 712 dbSNP
rs1275326747 714 dbSNP
rs1310518979 715 dbSNP
rs1209433114 721 dbSNP
rs1328298049 721 dbSNP
rs1463100699 722 dbSNP
rs1187192534 724 dbSNP
rs546008045 740 dbSNP
rs983395517 742 dbSNP
rs1018478719 751 dbSNP
rs1247848679 759 dbSNP
rs929189403 774 dbSNP
rs865966855 782 dbSNP
rs973056358 784 dbSNP
rs1421120213 791 dbSNP
rs969839683 804 dbSNP
rs571933018 816 dbSNP
rs868264807 818 dbSNP
rs1412275837 819 dbSNP
rs553515885 820 dbSNP
rs961133605 823 dbSNP
rs1454556371 825 dbSNP
rs1318438982 827 dbSNP
rs772316877 830 dbSNP
rs1192039353 838 dbSNP
rs997299970 841 dbSNP
rs1426293826 843 dbSNP
rs1035184581 845 dbSNP
rs1276757376 851 dbSNP
rs1254687788 862 dbSNP
rs644675 866 dbSNP
rs1467848748 870 dbSNP
rs1271238869 871 dbSNP
rs1197471983 889 dbSNP
rs902772237 895 dbSNP
rs3766227 896 dbSNP
rs887694107 901 dbSNP
rs1195710885 904 dbSNP
rs1055683906 906 dbSNP
rs1251894871 907 dbSNP
rs1022288131 910 dbSNP
rs762588802 915 dbSNP
rs1429444228 924 dbSNP
rs1470644732 925 dbSNP
rs1156860397 927 dbSNP
rs1046126136 929 dbSNP
rs1305877140 937 dbSNP
rs1401200537 943 dbSNP
rs1408884158 948 dbSNP
rs1320118338 951 dbSNP
rs900588047 952 dbSNP
rs1436087761 953 dbSNP
rs1370714899 954 dbSNP
rs1347501625 958 dbSNP
rs1322207286 977 dbSNP
rs1416876716 981 dbSNP
rs1330498626 982 dbSNP
rs1396591914 988 dbSNP
rs946181276 992 dbSNP
rs772711411 996 dbSNP
rs1039505860 998 dbSNP
rs75616990 999 dbSNP
rs1166764000 1001 dbSNP
rs1451375970 1003 dbSNP
rs1220406691 1010 dbSNP
rs1269064493 1022 dbSNP
rs1460170327 1024 dbSNP
rs115390291 1036 dbSNP
rs1410575697 1043 dbSNP
rs1054592128 1046 dbSNP
rs1160201421 1059 dbSNP
rs1388336925 1062 dbSNP
rs1404506476 1068 dbSNP
rs936138276 1069 dbSNP
rs911487007 1070 dbSNP
rs1408219241 1074 dbSNP
rs1307572477 1084 dbSNP
rs1336396540 1095 dbSNP
rs1453642265 1105 dbSNP
rs1250846331 1109 dbSNP
rs1282896914 1117 dbSNP
rs551487359 1118 dbSNP
rs985654776 1126 dbSNP
rs1294381612 1129 dbSNP
rs1490757063 1134 dbSNP
rs957850022 1155 dbSNP
rs537434713 1169 dbSNP
rs1202549720 1170 dbSNP
rs1251365099 1186 dbSNP
rs1195353779 1191 dbSNP
rs1437856253 1199 dbSNP
rs890308448 1200 dbSNP
rs1183942772 1209 dbSNP
rs1047591705 1212 dbSNP
rs1472351892 1213 dbSNP
rs767152492 1215 dbSNP
rs922992747 1217 dbSNP
rs1428108972 1220 dbSNP
rs1307635365 1229 dbSNP
rs1397336210 1236 dbSNP
rs1393175128 1244 dbSNP
rs1332780464 1251 dbSNP
rs1340458366 1257 dbSNP
rs1453980964 1258 dbSNP
rs1317654855 1263 dbSNP
rs929240471 1267 dbSNP
rs1273369958 1268 dbSNP
rs1445024066 1269 dbSNP
rs112430936 1270 dbSNP
rs1336816647 1275 dbSNP
rs1253447817 1277 dbSNP
rs1328743487 1278 dbSNP
rs1407500246 1286 dbSNP
rs1184098839 1296 dbSNP
rs961861808 1299 dbSNP
rs761755207 1301 dbSNP
rs920475616 1302 dbSNP
rs973066317 1305 dbSNP
rs948364141 1307 dbSNP
rs1006064047 1311 dbSNP
rs915674132 1318 dbSNP
rs1034284218 1328 dbSNP
rs1001474843 1336 dbSNP
rs1393075139 1337 dbSNP
rs1339210991 1338 dbSNP
rs907100327 1339 dbSNP
rs1160035987 1342 dbSNP
rs993017790 1346 dbSNP
rs1326718883 1351 dbSNP
rs1470378928 1358 dbSNP
rs959800530 1359 dbSNP
rs1253780878 1370 dbSNP
rs570564025 1372 dbSNP
rs1179572092 1374 dbSNP
rs1482150020 1389 dbSNP
rs552005787 1402 dbSNP
rs1259632046 1406 dbSNP
rs1211871044 1409 dbSNP
rs978223822 1412 dbSNP
rs1010650166 1413 dbSNP
rs58809301 1413 dbSNP
rs1054440645 1415 dbSNP
rs1225881701 1421 dbSNP
rs1196993664 1422 dbSNP
rs140515039 1422 dbSNP
rs1430557595 1422 dbSNP
rs147718568 1422 dbSNP
rs1470321173 1424 dbSNP
rs183654957 1436 dbSNP
rs1010925462 1443 dbSNP
rs965102201 1454 dbSNP
rs1049872995 1467 dbSNP
rs1356821504 1469 dbSNP
rs570482949 1492 dbSNP
rs1387558429 1519 dbSNP
rs922844665 1527 dbSNP
rs1009434930 1529 dbSNP
rs191925486 1532 dbSNP
rs1047601942 1540 dbSNP
rs186610745 1543 dbSNP
rs1285135281 1544 dbSNP
rs1327070091 1548 dbSNP
rs993289882 1549 dbSNP
rs899097818 1552 dbSNP
rs181521853 1554 dbSNP
rs371375090 1555 dbSNP
rs1156878495 1580 dbSNP
rs111904441 1590 dbSNP
rs1208316506 1590 dbSNP
rs200264588 1590 dbSNP
rs562342864 1590 dbSNP
rs1409844281 1591 dbSNP
rs1476106932 1594 dbSNP
rs1048380 1595 dbSNP
rs1160442191 1596 dbSNP
rs1188682407 1597 dbSNP
rs1365939103 1599 dbSNP
rs1456679194 1601 dbSNP
rs1474906601 1607 dbSNP
rs1364511654 1613 dbSNP
rs1405169550 1616 dbSNP
rs1304468704 1618 dbSNP
rs1348059176 1621 dbSNP
rs1235984079 1628 dbSNP
rs564477801 1634 dbSNP
rs545996939 1636 dbSNP
rs1307568484 1639 dbSNP
rs561709300 1640 dbSNP
rs1290743406 1650 dbSNP
rs669647 1658 dbSNP
rs1224968881 1665 dbSNP
rs188799816 1669 dbSNP
rs778719195 1672 dbSNP
rs1178318952 1677 dbSNP
rs1207425613 1682 dbSNP
rs1024602888 1684 dbSNP
rs1010251615 1685 dbSNP
rs891768090 1686 dbSNP
rs1337523318 1690 dbSNP
rs1424971205 1690 dbSNP
rs1165028224 1692 dbSNP
rs924331403 1695 dbSNP
rs1294423463 1699 dbSNP
rs978233591 1707 dbSNP
rs1054368379 1709 dbSNP
rs1232196727 1712 dbSNP
rs1375507460 1718 dbSNP
rs574434768 1739 dbSNP
rs1394185122 1741 dbSNP
rs1314196858 1750 dbSNP
rs1000267119 1755 dbSNP
rs1272665079 1764 dbSNP
rs1307021654 1770 dbSNP
rs1205242923 1780 dbSNP
rs889861446 1793 dbSNP
rs771214816 1801 dbSNP
rs1482603589 1802 dbSNP
rs915506916 1805 dbSNP
rs990162572 1815 dbSNP
rs1271635216 1819 dbSNP
rs1430942084 1828 dbSNP
rs964986627 1832 dbSNP
rs1318246437 1837 dbSNP
rs556172228 1838 dbSNP
rs1416890276 1839 dbSNP
rs746845066 1843 dbSNP
rs1008865054 1845 dbSNP
rs537878330 1847 dbSNP
rs940384477 1848 dbSNP
rs1335935364 1851 dbSNP
rs1411702814 1852 dbSNP
rs1454339135 1853 dbSNP
rs201303978 1853 dbSNP
rs373324884 1853 dbSNP
rs984441354 1881 dbSNP
rs993342279 1886 dbSNP
rs899024272 1889 dbSNP
rs1037525049 1891 dbSNP
rs1310461535 1894 dbSNP
rs1203593544 1895 dbSNP
rs1264259819 1903 dbSNP
rs927026379 1905 dbSNP
rs1187122822 1914 dbSNP
rs1241861182 1922 dbSNP
rs867962716 1923 dbSNP
rs906301485 1942 dbSNP
rs1474916509 1950 dbSNP
rs1247821959 1951 dbSNP
rs1186728645 1953 dbSNP
rs1421040844 1955 dbSNP
rs979963489 1960 dbSNP
rs971603824 1966 dbSNP
rs1406662672 1980 dbSNP
rs1024244060 2007 dbSNP
rs894386203 2030 dbSNP
rs1344377256 2036 dbSNP
rs1470082932 2040 dbSNP
rs1274424659 2041 dbSNP
rs1057210967 2049 dbSNP
rs1213605422 2050 dbSNP
rs989157488 2058 dbSNP
rs955942967 2071 dbSNP
rs1222931306 2073 dbSNP
rs1283980367 2076 dbSNP
rs558484689 2079 dbSNP
rs1326332050 2080 dbSNP
rs938322942 2084 dbSNP
rs924383727 2088 dbSNP
rs533875688 2089 dbSNP
rs1243449333 2090 dbSNP
rs531625182 2096 dbSNP
rs566566696 2097 dbSNP
rs1274421617 2099 dbSNP
rs1028790698 2100 dbSNP
rs1338283622 2102 dbSNP
rs947119914 2103 dbSNP
rs998374561 2115 dbSNP
rs778210160 2125 dbSNP
rs1442879493 2131 dbSNP
rs1156688392 2136 dbSNP
rs1176213857 2142 dbSNP
rs1371453217 2142 dbSNP
rs1401038403 2147 dbSNP
rs1320561523 2149 dbSNP
rs1364002585 2156 dbSNP
rs1325205133 2163 dbSNP
rs1434137092 2165 dbSNP
rs1348208398 2167 dbSNP
rs1172560788 2183 dbSNP
rs775424374 2186 dbSNP
rs1347453691 2188 dbSNP
rs1237539871 2192 dbSNP
rs1279416440 2199 dbSNP
rs185660302 2204 dbSNP
rs1166947936 2222 dbSNP
rs910764075 2225 dbSNP
rs1288138428 2232 dbSNP
rs1356871382 2233 dbSNP
rs181059096 2236 dbSNP
rs888694234 2240 dbSNP
rs1490679192 2244 dbSNP
rs562817205 2245 dbSNP
rs1232185960 2248 dbSNP
rs1191131600 2262 dbSNP
rs1160127307 2288 dbSNP
rs756349486 2289 dbSNP
rs1424328036 2292 dbSNP
rs1026303019 2296 dbSNP
rs1048800179 2298 dbSNP
rs930256712 2300 dbSNP
rs1441511148 2304 dbSNP
rs1389702797 2305 dbSNP
rs1487766674 2306 dbSNP
rs1336917804 2312 dbSNP
rs927037885 2322 dbSNP
rs980236011 2328 dbSNP
rs779527915 2331 dbSNP
rs1244802269 2332 dbSNP
rs1306378829 2336 dbSNP
rs754588123 2342 dbSNP
rs546171948 2347 dbSNP
rs1271643951 2350 dbSNP
rs1348339281 2356 dbSNP
rs1016546754 2360 dbSNP
rs1241056383 2376 dbSNP
rs1025034819 2378 dbSNP
rs1012719003 2383 dbSNP
rs894386613 2390 dbSNP
rs12794 2415 dbSNP
rs1375507457 2417 dbSNP
rs531997702 2418 dbSNP
rs902886602 2422 dbSNP
rs1041361687 2423 dbSNP
rs1412184660 2425 dbSNP
rs947172376 2427 dbSNP
rs886800036 2430 dbSNP
rs1335240240 2432 dbSNP
rs1306420790 2433 dbSNP
rs1436750791 2438 dbSNP
rs1197069137 2449 dbSNP
rs1317591146 2450 dbSNP
rs1048618412 2451 dbSNP
rs1341938507 2456 dbSNP
rs1224786517 2461 dbSNP
rs1269138721 2472 dbSNP
rs954015495 2475 dbSNP
rs1200459199 2476 dbSNP
rs1431776935 2483 dbSNP
rs755798328 2487 dbSNP
rs1410850162 2488 dbSNP
rs1178273227 2495 dbSNP
rs564333281 2499 dbSNP
rs1204115318 2507 dbSNP
rs1244710512 2514 dbSNP
rs943525007 2515 dbSNP
rs76849750 2516 dbSNP
rs1192723467 2518 dbSNP
rs1373728255 2520 dbSNP
rs777740516 2521 dbSNP
rs756181182 2531 dbSNP
rs910807291 2537 dbSNP
rs1028428504 2541 dbSNP
rs1406060560 2553 dbSNP
rs1470573360 2562 dbSNP
rs527830138 2569 dbSNP
rs998702448 2574 dbSNP
rs560205331 2575 dbSNP
rs1255031500 2588 dbSNP
rs1219880040 2604 dbSNP
rs1207806054 2608 dbSNP
rs1318500941 2609 dbSNP
rs767405662 2612 dbSNP
rs1307692581 2617 dbSNP
rs1257597973 2620 dbSNP
rs1484735312 2629 dbSNP
rs1204811224 2645 dbSNP
rs1262641650 2647 dbSNP
rs1016212732 2655 dbSNP
rs1197416586 2668 dbSNP
rs1004382935 2671 dbSNP
rs1481085058 2672 dbSNP
rs1179138085 2674 dbSNP
rs751645177 2686 dbSNP
rs1349959436 2694 dbSNP
rs560600115 2707 dbSNP
rs1286493679 2708 dbSNP
rs1287946548 2710 dbSNP
rs541659980 2714 dbSNP
rs1416875000 2724 dbSNP
rs1376340512 2725 dbSNP
rs919299611 2731 dbSNP
rs1401427197 2737 dbSNP
rs1048644392 2747 dbSNP
rs994518272 2754 dbSNP
rs1405492949 2756 dbSNP
rs905550637 2758 dbSNP
rs1314936449 2759 dbSNP
rs972053898 2764 dbSNP
rs1302449768 2767 dbSNP
rs879181340 2771 dbSNP
rs1464913880 2782 dbSNP
rs1261064584 2791 dbSNP
rs1356207538 2801 dbSNP
rs1347304355 2804 dbSNP
rs1220522672 2809 dbSNP
rs963465840 2813 dbSNP
rs188097285 2824 dbSNP
rs1409167264 2827 dbSNP
rs1193459684 2831 dbSNP
rs562665838 2832 dbSNP
rs991750354 2835 dbSNP
rs1418981804 2837 dbSNP
rs761592037 2844 dbSNP
rs1382547909 2846 dbSNP
rs138195684 2851 dbSNP
rs1161216834 2859 dbSNP
rs1002769821 2862 dbSNP
rs1364408619 2870 dbSNP
rs751539069 2873 dbSNP
rs1371148679 2875 dbSNP
rs185718920 2876 dbSNP
rs558314321 2877 dbSNP
rs193032673 2878 dbSNP
rs892893405 2879 dbSNP
rs1223931069 2880 dbSNP
rs147457897 2880 dbSNP
rs953949070 2880 dbSNP
rs1178263173 2885 dbSNP
rs573006969 2886 dbSNP
rs1486734805 2887 dbSNP
rs17102397 2893 dbSNP
rs141232877 2894 dbSNP
rs1326935031 2897 dbSNP
rs568576872 2901 dbSNP
rs1405562892 2902 dbSNP
rs1235256247 2906 dbSNP
rs1051933780 2915 dbSNP
rs1352250237 2931 dbSNP
rs1461432867 2935 dbSNP
rs933597007 2940 dbSNP
rs1402232835 2942 dbSNP
rs1450127029 2944 dbSNP
rs1394451465 2956 dbSNP
rs764040385 2959 dbSNP
rs1383848588 2962 dbSNP
rs1036368135 2977 dbSNP
rs1293592267 2979 dbSNP
rs748377325 2983 dbSNP
rs1205837153 2986 dbSNP
rs1289776133 2996 dbSNP
rs1457197623 3003 dbSNP
rs748148309 3011 dbSNP
rs909303078 3012 dbSNP
rs190322994 3025 dbSNP
rs1461564249 3032 dbSNP
rs1367324013 3040 dbSNP
rs1183183207 3048 dbSNP
rs1801801 3057 dbSNP
rs1184971477 3058 dbSNP
rs1427370225 3061 dbSNP
rs1171328089 3069 dbSNP
rs991617576 3071 dbSNP
rs952828439 3073 dbSNP
rs762834384 3076 dbSNP
rs928520846 3077 dbSNP
rs538161537 3079 dbSNP
rs1287260432 3083 dbSNP
rs1361395313 3084 dbSNP
rs1463351171 3088 dbSNP
rs967269086 3091 dbSNP
rs1280141289 3102 dbSNP
rs1002484579 3108 dbSNP
rs1020134311 3109 dbSNP
rs1254883869 3111 dbSNP
rs905434961 3114 dbSNP
rs1044492509 3119 dbSNP
rs776776691 3134 dbSNP
rs770856947 3137 dbSNP
rs1801799 3147 dbSNP
rs1211839366 3150 dbSNP
rs1239956310 3153 dbSNP
rs1485328646 3159 dbSNP
rs571121774 3160 dbSNP
rs1425141617 3171 dbSNP
rs895560897 3180 dbSNP
rs1052772461 3184 dbSNP
rs773300300 3186 dbSNP
rs1801800 3211 dbSNP
rs925814230 3212 dbSNP
rs1214229600 3221 dbSNP
rs1042860392 3224 dbSNP
rs772602017 3234 dbSNP
rs1300185371 3237 dbSNP
rs200087519 3243 dbSNP
rs1006678521 3246 dbSNP
rs540393099 3247 dbSNP
rs781747331 3255 dbSNP
rs1347609195 3257 dbSNP
rs1222474359 3258 dbSNP
rs1283966257 3260 dbSNP
rs1316035269 3271 dbSNP
rs1216868126 3284 dbSNP
rs1051945053 3285 dbSNP
rs997646515 3286 dbSNP
rs898099139 3289 dbSNP
rs1309433185 3296 dbSNP
rs148225926 3302 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000371933.3 | 3UTR | AAAGGGGAAAAAAAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000371933.3 | 3UTR | AAAGGGGAAAAAAAAACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
42 hsa-miR-4703-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT072026 SCP2 sterol carrier protein 2 2 2
MIRT079071 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT106648 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT178174 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT190328 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT230081 SH3BGRL SH3 domain binding glutamate rich protein like 2 2
MIRT238900 PEX3 peroxisomal biogenesis factor 3 2 2
MIRT473705 MAPK1 mitogen-activated protein kinase 1 2 6
MIRT481891 ANKRD46 ankyrin repeat domain 46 2 4
MIRT483743 ALDH9A1 aldehyde dehydrogenase 9 family member A1 2 2
MIRT488823 MRRF mitochondrial ribosome recycling factor 2 2
MIRT488990 SLC28A1 solute carrier family 28 member 1 2 2
MIRT504173 FAM127B retrotransposon Gag like 8A 2 2
MIRT524461 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT529787 AP4S1 adaptor related protein complex 4 sigma 1 subunit 2 2
MIRT546449 SLC9A7 solute carrier family 9 member A7 2 2
MIRT547827 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT561462 TCERG1 transcription elongation regulator 1 2 2
MIRT562315 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT563644 ZNF675 zinc finger protein 675 2 2
MIRT563741 ZNF107 zinc finger protein 107 2 4
MIRT568318 BACH1 BTB domain and CNC homolog 1 2 2
MIRT571528 ZNF367 zinc finger protein 367 2 2
MIRT574840 CADM1 cell adhesion molecule 1 2 2
MIRT612262 MNT MAX network transcriptional repressor 2 4
MIRT622234 SLC25A45 solute carrier family 25 member 45 2 2
MIRT625372 IRGQ immunity related GTPase Q 2 2
MIRT628260 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT631738 NKX2-1 NK2 homeobox 1 2 2
MIRT646103 GORAB golgin, RAB6 interacting 2 2
MIRT647768 AMOTL1 angiomotin like 1 2 2
MIRT654309 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT654988 PLCG2 phospholipase C gamma 2 2 2
MIRT659715 CCDC93 coiled-coil domain containing 93 2 2
MIRT666976 PHAX phosphorylated adaptor for RNA export 2 2
MIRT683247 WFDC6 WAP four-disulfide core domain 6 2 2
MIRT688424 DNAL1 dynein axonemal light chain 1 2 2
MIRT691896 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT701616 MYO1B myosin IB 2 2
MIRT702141 MAP3K1 mitogen-activated protein kinase kinase kinase 1 2 2
MIRT704403 CTPS1 CTP synthase 1 2 2
MIRT719515 RAB10 RAB10, member RAS oncogene family 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4703 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4703-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4703-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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