pre-miRNA Information
pre-miRNA hsa-mir-1273h   
Genomic Coordinates chr16: 24203116 - 24203231
Description Homo sapiens miR-1273h stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1273h-5p
Sequence 33| CUGGGAGGUCAAGGCUGCAGU |53
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1028034199 14 dbSNP
rs542383563 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC25A34   
Synonyms -
Description solute carrier family 25 member 34
Transcript NM_207348   
Expression
Putative miRNA Targets on SLC25A34
3'UTR of SLC25A34
(miRNA target sites are highlighted)
>SLC25A34|NM_207348|3'UTR
   1 ACGACGGCCCTCACCCCCACGTCCTGACACGGCCGGCACTTGGCCGGAAGTGAGAGCCTGCTCCAGGACAACTGGCTGTC
  81 CCGGGGCGGGCCATGGGCCCAGGCCCTGCCAGAGGTCCCGGGAGAGTGTGGACAGCTCTGGTCCATCCAGCCCCTTGGCC
 161 CACCCAGGTCCAGAGCATCCACTTCAAGTTACCACCCATTCTGTCTTCCAGACAGTTCTCTTCCTTCTCTGTACTGCGTA
 241 CTGGGTCACCACATCCCAGAGCCTTGCTCAGTTATAGCAACTGCTGCGGGCGTGCACATGGCATAGGCCCAGTAACTTAC
 321 ATACATCGGCTCACTTAGGCCTCAGACAGCAGCACGAGGCAGGCACTTTTACTTCTTTTACCATTAGAAAGCCAAGGCCT
 401 AGAGTGGTGGGCTTTGACCACAGCCACACAATTTTGAAGTGGCAGAGCCAGGACTGGAGCTTAGCCCTGCTCACCCTAGA
 481 CCTATGCGCTTGACAAGTGCGTGACTGTGACAGGCCCATGGGCCCGGACTGCCCATAGGGGTCACTGTACCATGGCAAAG
 561 GCTGAGGTGCACCAGGAGGCTGTGGCGTCGTCACCTGCCTTATTTGCTGGAGAAGCTGTAGCAAAGAACCACAGACTGGG
 641 CGACTTAGACAATAGAAATGTATTTTCTCACAGTTCTGGAGGCTGGATGCTGGAGACCAAGGTGTCAGTGGGCTGGTTTC
 721 TTCTGAGGCCTCTGTCCATGGCTTGCAGATGCTGCTTTCTCTCTGTGTCTGCACATGGTGGTCCCTCGATGTGCGTCTGG
 801 GTCCTGATCTCCTCCTCTTATAAGGACACAAATCATGTTGGCTTAGGGCCCACCCTCATGACCCCACTTTAATTTTTTTT
 881 TTTTTTTTTGAGATGAAGTCTCACTCTGCCACCCAAGCTGGAGTGCAGTGGCACGATCTCGGTTCACTGCAACCTTGGCC
 961 TCCTAGGTTCAAGCAATTCTCCTGCCCCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACACCCGGCCAATT
1041 TTTGTATCTTTAGTAGAGATGGGGTTTTGCCATGTTGGCCAGACTGGTCTCGAACTCCTGACCTCAAGTGATCCACTGGC
1121 CTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCTCACTTGGCCCAATTTTAACTTAATTATCTCTGTCAAGA
1201 GCCTATCTCCATATACAGTCACATCCTGAGCTACTAGGGGGTAGGACTTCAACATGCACTTCTGCAGGGGCCGCAGTTCA
1281 GCCAACATCATCTTTTTTTTTGAGATGGAGTCTCGCTTTGTTGCCCAGGCTGGAGTGCGGTGGTGCAATCTCGGCTCACC
1361 ACAACCTCCACCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTTGCTGGGACTATAGGTGTGCGCCACCAT
1441 GCCCAGCTAATTTTGTATTTTTAGTAGAGACAGGCTTTCGCTGTGTTGGCCAGGCTGGTCTTGAATGCCTGACCTTGCCG
1521 CCCGCCTCGGCCTCCCAAAATGCTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCTCAGCCAACATCATCTAAGGGCTC
1601 TCACGGAGGGCCTCCCAGCTGCCCGCCCTGTGGGCATTTGCACATATCCTGACAAGCCTGAAAGAAGCTCCGGGTGCCCA
1681 TTGTTCAGTCCAGGTGCCCATTGTTCCCGGGACTGAGGCCCGGGAAAGGGAAGCGACGTGGCAGGGCCAGCAGCAGACCC
1761 TGGGCCTTTCTCTAGACTGAGCACCATTCCCCGTGGGTGTGCTCTCAGCGCCGCACCGACCTTCACACTGCAGAGATGGA
1841 TGCCAACTCCCTGGCAGGGGCAGGACTGCTGCCGAGCAGCCCCACCTGCCCTCCCAGCCACACCCCAAGTCTGTAAGGGC
1921 CGCTCCCAGGAACACCTGCTACTGCACACTCCAAACCAATAAAGTTTTATATTTTGTTTACTTCAAAAAAAAAAAAAAAA
2001 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugacGUCGGAACUGGAGGGUc 5'
              ::||||||:||||||| 
Target 5' ccacTGGCCTTGGCCTCCCAa 3'
1113 - 1133 173.00 -29.00
2
miRNA  3' ugACGUCGGAACUGGAGGGUc 5'
            |||| |||||:|||||:| 
Target 5' acTGCAACCTTGGCCTCCTAg 3'
946 - 966 167.00 -34.20
3
miRNA  3' ugacGUCGGAACUGGAGGGUc 5'
              | |||| |:||||||| 
Target 5' ccgcCCGCCTCGGCCTCCCAa 3'
1518 - 1538 165.00 -22.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28632958 4 COSMIC
COSN26995084 6 COSMIC
COSN26709064 27 COSMIC
COSN30133137 36 COSMIC
COSN30516695 83 COSMIC
COSN30103972 84 COSMIC
COSN31503465 85 COSMIC
COSN31570837 88 COSMIC
COSN21652331 789 COSMIC
COSN29563290 1302 COSMIC
COSN25751473 1590 COSMIC
COSN7052420 1698 COSMIC
COSN21830683 1716 COSMIC
COSN8645784 1716 COSMIC
COSN26574122 1958 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs199527973 3 dbSNP
rs774124240 4 dbSNP
rs368900033 6 dbSNP
rs201763026 7 dbSNP
rs1241443331 8 dbSNP
rs376515393 9 dbSNP
rs200654845 10 dbSNP
rs200069227 12 dbSNP
rs1278059574 14 dbSNP
rs941371384 17 dbSNP
rs201412857 19 dbSNP
rs776487836 21 dbSNP
rs376622257 22 dbSNP
rs764846172 30 dbSNP
rs752166521 31 dbSNP
rs768013989 32 dbSNP
rs750739413 35 dbSNP
rs756521763 36 dbSNP
rs1400910147 37 dbSNP
rs754157648 38 dbSNP
rs1300362892 43 dbSNP
rs763576452 44 dbSNP
rs778166727 46 dbSNP
rs778992975 47 dbSNP
rs748180983 48 dbSNP
rs1485025785 51 dbSNP
rs747395939 58 dbSNP
rs1325178072 66 dbSNP
rs1051569021 72 dbSNP
rs1337878917 77 dbSNP
rs147697436 83 dbSNP
rs1024522709 86 dbSNP
rs971245056 88 dbSNP
rs1205571627 91 dbSNP
rs1263829131 100 dbSNP
rs1359992129 101 dbSNP
rs1457532044 104 dbSNP
rs547625949 105 dbSNP
rs1038958752 110 dbSNP
rs904148160 113 dbSNP
rs1182466712 117 dbSNP
rs1342854099 118 dbSNP
rs924511211 120 dbSNP
rs957063059 121 dbSNP
rs1178049047 128 dbSNP
rs1429361393 134 dbSNP
rs76700094 153 dbSNP
rs1328827895 156 dbSNP
rs1366252974 170 dbSNP
rs989744635 172 dbSNP
rs921015072 179 dbSNP
rs1014414672 180 dbSNP
rs932359312 185 dbSNP
rs1050858558 195 dbSNP
rs1283614945 212 dbSNP
rs1253243231 216 dbSNP
rs1024457960 232 dbSNP
rs777259282 238 dbSNP
rs571402402 239 dbSNP
rs944876402 244 dbSNP
rs1002151889 248 dbSNP
rs60323818 249 dbSNP
rs35148144 255 dbSNP
rs1477184362 263 dbSNP
rs1477057013 271 dbSNP
rs1374374130 272 dbSNP
rs1462179071 274 dbSNP
rs1163102446 276 dbSNP
rs555829081 278 dbSNP
rs1389002018 284 dbSNP
rs34588506 288 dbSNP
rs547494915 288 dbSNP
rs774980728 289 dbSNP
rs1400339853 292 dbSNP
rs1157149270 293 dbSNP
rs140463513 299 dbSNP
rs1244315027 303 dbSNP
rs1420736739 314 dbSNP
rs1303035119 321 dbSNP
rs894566144 321 dbSNP
rs918652805 322 dbSNP
rs117849659 328 dbSNP
rs761311013 329 dbSNP
rs1487680417 342 dbSNP
rs1276110054 343 dbSNP
rs907052884 356 dbSNP
rs998632373 357 dbSNP
rs1383813694 365 dbSNP
rs767182824 367 dbSNP
rs1164788881 373 dbSNP
rs1238959005 376 dbSNP
rs1306687612 381 dbSNP
rs1355541575 383 dbSNP
rs1418401016 391 dbSNP
rs1290768336 394 dbSNP
rs149412777 404 dbSNP
rs370249823 404 dbSNP
rs957245897 406 dbSNP
rs200791665 412 dbSNP
rs1395707405 416 dbSNP
rs556559585 417 dbSNP
rs1380333330 419 dbSNP
rs1247821164 420 dbSNP
rs750106157 428 dbSNP
rs1449801350 440 dbSNP
rs925928188 454 dbSNP
rs1213536452 456 dbSNP
rs1223768583 457 dbSNP
rs1247355864 477 dbSNP
rs935653940 478 dbSNP
rs760430788 482 dbSNP
rs1446827606 486 dbSNP
rs953735776 488 dbSNP
rs1461033532 489 dbSNP
rs986980404 496 dbSNP
rs570362841 498 dbSNP
rs538249415 499 dbSNP
rs912302608 500 dbSNP
rs944872078 501 dbSNP
rs1013977518 502 dbSNP
rs749002332 511 dbSNP
rs1465563405 512 dbSNP
rs866217169 519 dbSNP
rs1334980456 521 dbSNP
rs919509874 523 dbSNP
rs1453643354 527 dbSNP
rs1045508961 537 dbSNP
rs1315535259 537 dbSNP
rs1163353981 545 dbSNP
rs1222038219 547 dbSNP
rs1308998996 548 dbSNP
rs906026498 552 dbSNP
rs1407570486 562 dbSNP
rs1324847818 569 dbSNP
rs1001742251 570 dbSNP
rs1260700487 573 dbSNP
rs1462420655 581 dbSNP
rs1017590435 582 dbSNP
rs558634375 587 dbSNP
rs753724825 588 dbSNP
rs1328817934 589 dbSNP
rs754937803 590 dbSNP
rs768175068 591 dbSNP
rs894504497 596 dbSNP
rs1409279213 603 dbSNP
rs1432673037 604 dbSNP
rs994845404 607 dbSNP
rs374186698 620 dbSNP
rs955382480 621 dbSNP
rs1353731027 622 dbSNP
rs1439678964 628 dbSNP
rs541090331 630 dbSNP
rs1229942267 632 dbSNP
rs1290556739 638 dbSNP
rs1457341968 639 dbSNP
rs149719236 642 dbSNP
rs758474698 643 dbSNP
rs574522897 648 dbSNP
rs1458385850 649 dbSNP
rs1325032642 650 dbSNP
rs1187186169 652 dbSNP
rs1367072402 668 dbSNP
rs543634428 671 dbSNP
rs1474006363 683 dbSNP
rs1306137658 688 dbSNP
rs964895576 692 dbSNP
rs974633649 696 dbSNP
rs1488469492 710 dbSNP
rs925846039 727 dbSNP
rs935912215 728 dbSNP
rs907256164 735 dbSNP
rs1170253883 739 dbSNP
rs912860252 747 dbSNP
rs1411864484 752 dbSNP
rs998663548 759 dbSNP
rs1172340446 765 dbSNP
rs1354874028 766 dbSNP
rs1404298853 768 dbSNP
rs1164306419 771 dbSNP
rs1301172451 776 dbSNP
rs563425404 779 dbSNP
rs949737516 785 dbSNP
rs1031433000 788 dbSNP
rs1215943192 791 dbSNP
rs892964429 795 dbSNP
rs145617963 796 dbSNP
rs1167930738 798 dbSNP
rs1490535621 809 dbSNP
rs371748365 810 dbSNP
rs1193127239 813 dbSNP
rs1240418486 822 dbSNP
rs905638824 825 dbSNP
rs1187298155 835 dbSNP
rs1401933837 850 dbSNP
rs1028224012 851 dbSNP
rs1161605931 854 dbSNP
rs545694883 859 dbSNP
rs1333157740 863 dbSNP
rs943833202 867 dbSNP
rs1425214067 868 dbSNP
rs898673090 871 dbSNP
rs111980418 873 dbSNP
rs1382515495 873 dbSNP
rs1432502843 873 dbSNP
rs753609049 873 dbSNP
rs994396459 873 dbSNP
rs1317608915 876 dbSNP
rs1360869576 890 dbSNP
rs77388716 890 dbSNP
rs80141332 891 dbSNP
rs1317237546 892 dbSNP
rs1216801059 896 dbSNP
rs1260069194 898 dbSNP
rs1448770277 901 dbSNP
rs532984388 904 dbSNP
rs372218332 907 dbSNP
rs1237057798 909 dbSNP
rs1200068715 911 dbSNP
rs564894671 922 dbSNP
rs1386844448 929 dbSNP
rs1445210689 932 dbSNP
rs1157891434 935 dbSNP
rs953875454 939 dbSNP
rs551073786 942 dbSNP
rs986455074 957 dbSNP
rs1401884385 969 dbSNP
rs778026124 976 dbSNP
rs386628847 987 dbSNP
rs148912997 988 dbSNP
rs143436673 989 dbSNP
rs1449997798 992 dbSNP
rs1339163989 995 dbSNP
rs972230805 998 dbSNP
rs1383947182 1023 dbSNP
rs919458887 1026 dbSNP
rs530217585 1029 dbSNP
rs550392459 1033 dbSNP
rs1352952482 1037 dbSNP
rs1224340652 1040 dbSNP
rs1196546567 1050 dbSNP
rs1425128324 1054 dbSNP
rs1460192840 1061 dbSNP
rs1462090440 1061 dbSNP
rs985468067 1065 dbSNP
rs570252709 1071 dbSNP
rs979945164 1079 dbSNP
rs1181022297 1080 dbSNP
rs1032818882 1085 dbSNP
rs1471117782 1088 dbSNP
rs1399641558 1090 dbSNP
rs1427965031 1092 dbSNP
rs866409131 1093 dbSNP
rs1178094000 1103 dbSNP
rs1407326367 1104 dbSNP
rs957431978 1117 dbSNP
rs539294722 1127 dbSNP
rs747247295 1131 dbSNP
rs1443542450 1138 dbSNP
rs34573405 1140 dbSNP
rs916150342 1140 dbSNP
rs1334572384 1142 dbSNP
rs1282779664 1148 dbSNP
rs948742945 1152 dbSNP
rs1225609291 1158 dbSNP
rs1263931616 1159 dbSNP
rs949685766 1175 dbSNP
rs1339667851 1184 dbSNP
rs1248134728 1195 dbSNP
rs1439542593 1202 dbSNP
rs55811728 1206 dbSNP
rs928719301 1210 dbSNP
rs1267593987 1215 dbSNP
rs1248681131 1216 dbSNP
rs1178158088 1217 dbSNP
rs565648873 1219 dbSNP
rs1429470958 1239 dbSNP
rs569442301 1240 dbSNP
rs534628095 1241 dbSNP
rs1232660205 1242 dbSNP
rs1399051425 1242 dbSNP
rs1411052115 1255 dbSNP
rs1303026702 1258 dbSNP
rs937077801 1265 dbSNP
rs1283996202 1272 dbSNP
rs1326130830 1273 dbSNP
rs1053130542 1274 dbSNP
rs1225489572 1286 dbSNP
rs1038534933 1291 dbSNP
rs898629504 1293 dbSNP
rs1205810687 1298 dbSNP
rs1201320347 1309 dbSNP
rs554351081 1311 dbSNP
rs1201037628 1312 dbSNP
rs892996457 1316 dbSNP
rs183897620 1317 dbSNP
rs1047300075 1321 dbSNP
rs1196436116 1324 dbSNP
rs543247800 1327 dbSNP
rs1050122706 1329 dbSNP
rs891399776 1339 dbSNP
rs376272234 1340 dbSNP
rs1364330602 1343 dbSNP
rs1008168979 1347 dbSNP
rs140825545 1349 dbSNP
rs781716030 1353 dbSNP
rs576973736 1354 dbSNP
rs746313646 1358 dbSNP
rs1294039824 1360 dbSNP
rs770434651 1367 dbSNP
rs1000915865 1370 dbSNP
rs1173939992 1377 dbSNP
rs1314103934 1387 dbSNP
rs1357259560 1393 dbSNP
rs1224597168 1408 dbSNP
rs1265554386 1409 dbSNP
rs1359638051 1410 dbSNP
rs1417675340 1419 dbSNP
rs1032877100 1425 dbSNP
rs1449697712 1428 dbSNP
rs993955187 1433 dbSNP
rs545658097 1434 dbSNP
rs988668777 1441 dbSNP
rs952218511 1443 dbSNP
rs1020202182 1448 dbSNP
rs1332968680 1454 dbSNP
rs984947342 1464 dbSNP
rs981375793 1467 dbSNP
rs926940684 1474 dbSNP
rs916167005 1478 dbSNP
rs11583852 1480 dbSNP
rs1308859674 1481 dbSNP
rs1351916983 1492 dbSNP
rs1236338337 1494 dbSNP
rs930126110 1496 dbSNP
rs1219276192 1517 dbSNP
rs1465111576 1517 dbSNP
rs1287296837 1520 dbSNP
rs982093598 1521 dbSNP
rs928679465 1524 dbSNP
rs944269192 1525 dbSNP
rs1250342770 1526 dbSNP
rs1040359986 1528 dbSNP
rs1253107725 1529 dbSNP
rs899826608 1530 dbSNP
rs934644443 1537 dbSNP
rs572086128 1541 dbSNP
rs1403660871 1542 dbSNP
rs1449875846 1544 dbSNP
rs914631571 1545 dbSNP
rs1372595535 1554 dbSNP
rs1389586151 1555 dbSNP
rs947228825 1558 dbSNP
rs1049543100 1563 dbSNP
rs1222551967 1566 dbSNP
rs113483112 1567 dbSNP
rs1326106269 1568 dbSNP
rs377466145 1569 dbSNP
rs1251090370 1572 dbSNP
rs1160248630 1583 dbSNP
rs559706822 1584 dbSNP
rs561218248 1586 dbSNP
rs1053859633 1588 dbSNP
rs1252667291 1597 dbSNP
rs530261737 1605 dbSNP
rs1009669348 1606 dbSNP
rs1431808259 1609 dbSNP
rs72647155 1625 dbSNP
rs993819472 1626 dbSNP
rs1353680446 1635 dbSNP
rs563867527 1650 dbSNP
rs1026747558 1659 dbSNP
rs952415630 1664 dbSNP
rs1006803489 1669 dbSNP
rs1002757512 1670 dbSNP
rs532773039 1672 dbSNP
rs1347066946 1673 dbSNP
rs926428608 1673 dbSNP
rs970628733 1673 dbSNP
rs981741646 1675 dbSNP
rs928879153 1678 dbSNP
rs1242686853 1679 dbSNP
rs956055441 1681 dbSNP
rs1310448878 1683 dbSNP
rs1306086942 1686 dbSNP
rs760340912 1687 dbSNP
rs951105274 1694 dbSNP
rs187604323 1695 dbSNP
rs1220429742 1697 dbSNP
rs1271115854 1701 dbSNP
rs914664194 1709 dbSNP
rs566409489 1710 dbSNP
rs528403139 1714 dbSNP
rs11578534 1715 dbSNP
rs1426460946 1720 dbSNP
rs745711185 1722 dbSNP
rs548214427 1723 dbSNP
rs753634060 1724 dbSNP
rs897043997 1731 dbSNP
rs1351084091 1735 dbSNP
rs572452900 1736 dbSNP
rs537108936 1738 dbSNP
rs1054168574 1739 dbSNP
rs892489943 1741 dbSNP
rs191174782 1742 dbSNP
rs184051975 1743 dbSNP
rs539277179 1747 dbSNP
rs888200819 1749 dbSNP
rs1012038460 1758 dbSNP
rs1294087431 1765 dbSNP
rs1452206470 1767 dbSNP
rs1461982059 1773 dbSNP
rs1215351882 1775 dbSNP
rs907027434 1779 dbSNP
rs1486968542 1784 dbSNP
rs552834333 1786 dbSNP
rs1003158082 1788 dbSNP
rs1398289474 1790 dbSNP
rs761541894 1793 dbSNP
rs572842927 1794 dbSNP
rs79757554 1810 dbSNP
rs1035923086 1811 dbSNP
rs549863900 1813 dbSNP
rs561290736 1814 dbSNP
rs1394681418 1818 dbSNP
rs988782749 1821 dbSNP
rs1286414494 1822 dbSNP
rs1027041454 1835 dbSNP
rs1223353742 1859 dbSNP
rs1021616383 1866 dbSNP
rs1282225660 1870 dbSNP
rs150257583 1874 dbSNP
rs543867070 1875 dbSNP
rs1256863256 1876 dbSNP
rs563656861 1880 dbSNP
rs943898292 1882 dbSNP
rs1200108606 1885 dbSNP
rs976558181 1899 dbSNP
rs1157537485 1907 dbSNP
rs918509980 1911 dbSNP
rs929844365 1920 dbSNP
rs1048340093 1922 dbSNP
rs921457651 1926 dbSNP
rs888143761 1935 dbSNP
rs1336556740 1944 dbSNP
rs1482778286 1964 dbSNP
rs947698604 1971 dbSNP
rs1054044992 1977 dbSNP
rs1352367319 1985 dbSNP
rs1229267137 1987 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000294454.5 | 3UTR | AAGUGAUCCACUGGCCUUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000294454.5 | 3UTR | CACUGGCCUUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000294454.5 | 3UTR | ACUGGCCUUGGCCUCCCAAAGUGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000294454.5 | 3UTR | CACUGGCCUUGGCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
494 hsa-miR-1273h-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074355 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT100721 TJAP1 tight junction associated protein 1 2 2
MIRT115545 MAZ MYC associated zinc finger protein 2 2
MIRT124982 XIAP X-linked inhibitor of apoptosis 2 4
MIRT139911 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT177183 ARL5B ADP ribosylation factor like GTPase 5B 2 4
MIRT187994 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT207410 MAT2A methionine adenosyltransferase 2A 2 6
MIRT241928 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT260110 KLHL21 kelch like family member 21 2 2
MIRT260358 XRCC6 X-ray repair cross complementing 6 2 6
MIRT266428 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT294663 ZNF548 zinc finger protein 548 2 2
MIRT351039 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT379943 PRRG4 proline rich and Gla domain 4 2 2
MIRT398983 KAT7 lysine acetyltransferase 7 2 2
MIRT441465 BEST3 bestrophin 3 2 2
MIRT446750 ZNF491 zinc finger protein 491 2 2
MIRT449224 RAD51B RAD51 paralog B 2 2
MIRT450623 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT451090 ZNF584 zinc finger protein 584 2 2
MIRT451558 CIAPIN1 cytokine induced apoptosis inhibitor 1 2 2
MIRT451736 CES3 carboxylesterase 3 2 2
MIRT452411 QDPR quinoid dihydropteridine reductase 2 2
MIRT452559 ZFP69B ZFP69 zinc finger protein B 2 2
MIRT452851 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT452922 DISC1 disrupted in schizophrenia 1 2 2
MIRT453043 TANGO2 transport and golgi organization 2 homolog 2 4
MIRT453097 HOXC4 homeobox C4 2 2
MIRT453297 ZNF394 zinc finger protein 394 2 2
MIRT453593 ZNF557 zinc finger protein 557 2 2
MIRT453787 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT453987 CECR1 adenosine deaminase 2 2 2
MIRT454083 TMEM209 transmembrane protein 209 2 2
MIRT454652 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT454753 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2 2
MIRT455311 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT456468 SERAC1 serine active site containing 1 2 2
MIRT456554 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT456716 TMEM239 transmembrane protein 239 2 4
MIRT456796 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT457487 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457999 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458130 TLCD2 TLC domain containing 2 2 2
MIRT459027 ZNF490 zinc finger protein 490 2 4
MIRT459119 FADS6 fatty acid desaturase 6 2 2
MIRT459315 HAVCR2 hepatitis A virus cellular receptor 2 2 2
MIRT459385 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT459412 FAM83B family with sequence similarity 83 member B 2 2
MIRT459974 RFT1 RFT1 homolog 2 2
MIRT460480 FAM105A family with sequence similarity 105 member A 2 6
MIRT460586 FEM1A fem-1 homolog A 2 2
MIRT460920 NOA1 nitric oxide associated 1 2 4
MIRT461072 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461590 DPH2 DPH2 homolog 2 2
MIRT461854 ZNF317 zinc finger protein 317 2 2
MIRT462176 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT462446 GCDH glutaryl-CoA dehydrogenase 2 2
MIRT463854 WNT7B Wnt family member 7B 2 2
MIRT464310 UST uronyl 2-sulfotransferase 2 2
MIRT464815 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT465453 TOR2A torsin family 2 member A 2 2
MIRT466073 TMEM184C transmembrane protein 184C 2 2
MIRT466514 TBXA2R thromboxane A2 receptor 2 2
MIRT467072 SRRD SRR1 domain containing 2 2
MIRT469551 RARA retinoic acid receptor alpha 2 2
MIRT469741 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT470759 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT470875 PLXND1 plexin D1 2 2
MIRT470976 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT471048 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2 2
MIRT471215 PHAX phosphorylated adaptor for RNA export 2 2
MIRT471246 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471286 PGAM4 phosphoglycerate mutase family member 4 2 2
MIRT471467 PDE7B phosphodiesterase 7B 2 2
MIRT473069 MORN4 MORN repeat containing 4 2 4
MIRT473989 LRRC20 leucine rich repeat containing 20 2 2
MIRT474518 KLHDC8A kelch domain containing 8A 2 2
MIRT474990 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT475547 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 2
MIRT476350 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT477298 EPHB2 EPH receptor B2 2 2
MIRT477933 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478282 DDX19A DEAD-box helicase 19A 2 4
MIRT478472 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT478559 CTNND1 catenin delta 1 2 2
MIRT478618 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT478834 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT479007 COL5A1 collagen type V alpha 1 chain 2 2
MIRT479166 CLSPN claspin 2 2
MIRT482454 ADAR adenosine deaminase, RNA specific 2 4
MIRT483019 KHSRP KH-type splicing regulatory protein 2 4
MIRT483798 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT486087 SLC7A5 solute carrier family 7 member 5 2 4
MIRT486304 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486490 MYH11 myosin heavy chain 11 2 2
MIRT486881 TSPYL4 TSPY like 4 2 2
MIRT487125 NCOR2 nuclear receptor corepressor 2 2 2
MIRT487542 TM6SF2 transmembrane 6 superfamily member 2 2 4
MIRT487676 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT489251 TTLL1 tubulin tyrosine ligase like 1 2 4
MIRT489276 RBM8A RNA binding motif protein 8A 2 8
MIRT489496 CRLF3 cytokine receptor like factor 3 2 4
MIRT489571 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489694 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT490166 TMEM63C transmembrane protein 63C 2 2
MIRT491199 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT491260 DHX40 DEAH-box helicase 40 2 2
MIRT491385 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT491548 YAE1D1 Yae1 domain containing 1 2 2
MIRT492722 PHF12 PHD finger protein 12 2 2
MIRT493866 FAM73B mitoguardin 2 2 4
MIRT494549 BAK1 BCL2 antagonist/killer 1 2 2
MIRT498586 KRT8 keratin 8 2 2
MIRT498722 SNTN sentan, cilia apical structure protein 2 6
MIRT499982 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT503414 SLC25A45 solute carrier family 25 member 45 2 6
MIRT508491 FTO FTO, alpha-ketoglutarate dependent dioxygenase 2 2
MIRT508877 METTL14 methyltransferase like 14 2 2
MIRT509622 RRP7A ribosomal RNA processing 7 homolog A 2 4
MIRT510104 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT510139 PDGFRA platelet derived growth factor receptor alpha 2 4
MIRT510353 ZNF703 zinc finger protein 703 2 6
MIRT510620 TMEM167A transmembrane protein 167A 2 4
MIRT510786 SF3B3 splicing factor 3b subunit 3 2 6
MIRT511021 NRF1 nuclear respiratory factor 1 2 2
MIRT513925 GHITM growth hormone inducible transmembrane protein 2 2
MIRT514342 DNAH17 dynein axonemal heavy chain 17 2 4
MIRT515015 SUMF2 sulfatase modifying factor 2 2 2
MIRT515246 DUSP28 dual specificity phosphatase 28 2 2
MIRT516202 RPP30 ribonuclease P/MRP subunit p30 2 2
MIRT516435 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT516666 ZNF860 zinc finger protein 860 2 4
MIRT518373 ZNF250 zinc finger protein 250 2 2
MIRT518930 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT519676 ZNF70 zinc finger protein 70 2 2
MIRT519902 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT519945 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT520321 UBXN2A UBX domain protein 2A 2 2
MIRT520606 TMEM41B transmembrane protein 41B 2 2
MIRT520663 TMEM11 transmembrane protein 11 2 2
MIRT520852 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521443 RAD51 RAD51 recombinase 2 2
MIRT521671 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT522281 NKAP NFKB activating protein 2 2
MIRT522333 NCKIPSD NCK interacting protein with SH3 domain 2 8
MIRT522535 MED28 mediator complex subunit 28 2 6
MIRT523478 GNG4 G protein subunit gamma 4 2 2
MIRT523672 FOPNL FGFR1OP N-terminal like 2 2
MIRT523715 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523867 ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2 4
MIRT524043 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT524167 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT524928 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT526825 PHC1 polyhomeotic homolog 1 2 2
MIRT531017 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT536085 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT540681 BMP3 bone morphogenetic protein 3 2 2
MIRT541708 TMEM33 transmembrane protein 33 2 2
MIRT541755 KLF8 Kruppel like factor 8 2 2
MIRT541888 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT545714 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT559054 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT561748 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT562365 ETV3 ETS variant 3 2 2
MIRT562821 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT562900 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT564452 SLC35E2 solute carrier family 35 member E2 2 5
MIRT569111 ONECUT3 one cut homeobox 3 2 2
MIRT569224 SUSD1 sushi domain containing 1 2 2
MIRT570271 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570498 TFIP11 tuftelin interacting protein 11 2 2
MIRT570844 GPRC5C G protein-coupled receptor class C group 5 member C 2 2
MIRT571311 TPCN2 two pore segment channel 2 2 2
MIRT572077 EXOC8 exocyst complex component 8 2 2
MIRT572116 DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 2 2
MIRT573054 TRIB1 tribbles pseudokinase 1 2 2
MIRT573483 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT573656 HES6 hes family bHLH transcription factor 6 2 2
MIRT574343 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT576494 Slc35e2 solute carrier family 35, member E2 2 4
MIRT608033 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT611326 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT613660 KIAA1210 KIAA1210 2 2
MIRT615638 ATF6 activating transcription factor 6 2 2
MIRT618573 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT618865 MBL2 mannose binding lectin 2 2 2
MIRT618962 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT619172 SLC16A4 solute carrier family 16 member 4 2 2
MIRT620298 AQP6 aquaporin 6 2 2
MIRT620683 RFTN2 raftlin family member 2 2 2
MIRT621637 UBXN2B UBX domain protein 2B 2 2
MIRT621993 STK4 serine/threonine kinase 4 2 2
MIRT622421 NUDT19 nudix hydrolase 19 2 2
MIRT622804 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 4
MIRT624786 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT624968 ZNF665 zinc finger protein 665 2 4
MIRT625479 SMAD9 SMAD family member 9 2 2
MIRT626594 ACAA2 acetyl-CoA acyltransferase 2 2 4
MIRT626708 TRIM65 tripartite motif containing 65 2 2
MIRT626975 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT627489 STRIP2 striatin interacting protein 2 2 2
MIRT628505 ZNF878 zinc finger protein 878 2 2
MIRT628533 ZNF701 zinc finger protein 701 2 2
MIRT628591 TMEM251 transmembrane protein 251 2 2
MIRT628818 SLC25A34 solute carrier family 25 member 34 2 2
MIRT628896 IGSF6 immunoglobulin superfamily member 6 2 2
MIRT628958 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 2
MIRT629005 OSBPL10 oxysterol binding protein like 10 2 2
MIRT629059 KIF1C kinesin family member 1C 2 2
MIRT629192 PAPOLA poly(A) polymerase alpha 2 2
MIRT629346 TMPRSS11BNL TMPRSS11B N-terminal like, pseudogene 2 2
MIRT629447 WIZ widely interspaced zinc finger motifs 2 2
MIRT629696 XKR4 XK related 4 2 2
MIRT629737 SCD5 stearoyl-CoA desaturase 5 2 2
MIRT629896 SPATA5 spermatogenesis associated 5 2 2
MIRT629953 GLP2R glucagon like peptide 2 receptor 2 2
MIRT630023 MTL5 testis expressed metallothionein like protein 2 2
MIRT630181 TLN1 talin 1 2 2
MIRT630325 PAQR5 progestin and adipoQ receptor family member 5 2 2
MIRT630389 MYH9 myosin heavy chain 9 2 4
MIRT630695 EXTL3 exostosin like glycosyltransferase 3 2 2
MIRT631054 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT631130 SYNJ2 synaptojanin 2 2 2
MIRT631374 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT631557 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT631615 PCDHB11 protocadherin beta 11 2 2
MIRT631935 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 4
MIRT632109 SSR1 signal sequence receptor subunit 1 2 2
MIRT632168 CCL22 C-C motif chemokine ligand 22 2 2
MIRT632445 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT632652 NAV1 neuron navigator 1 2 2
MIRT632688 MTMR10 myotubularin related protein 10 2 2
MIRT632828 IGF1 insulin like growth factor 1 2 2
MIRT632905 FRRS1 ferric chelate reductase 1 2 2
MIRT633027 DNAL1 dynein axonemal light chain 1 2 2
MIRT633379 FBXW8 F-box and WD repeat domain containing 8 2 2
MIRT633440 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633726 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT633832 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT633862 ATP6V1A ATPase H+ transporting V1 subunit A 2 2
MIRT634042 NUP155 nucleoporin 155 2 2
MIRT634266 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634374 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT634439 PDE7A phosphodiesterase 7A 2 2
MIRT634573 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT634620 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT634693 DSEL dermatan sulfate epimerase-like 2 2
MIRT634768 CD3D CD3d molecule 2 2
MIRT635024 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT635384 NHLRC2 NHL repeat containing 2 2 2
MIRT635577 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT635793 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT635837 ZNF264 zinc finger protein 264 2 2
MIRT636043 ZSCAN29 zinc finger and SCAN domain containing 29 2 4
MIRT636070 ZNF280C zinc finger protein 280C 2 2
MIRT636697 ARSK arylsulfatase family member K 2 2
MIRT637438 ZNF324B zinc finger protein 324B 2 2
MIRT637582 PLD6 phospholipase D family member 6 2 2
MIRT637672 PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D 2 2
MIRT637887 SLC19A3 solute carrier family 19 member 3 2 4
MIRT638353 RBMS2 RNA binding motif single stranded interacting protein 2 2 4
MIRT638597 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT638821 CRTAP cartilage associated protein 2 2
MIRT638871 CEP97 centrosomal protein 97 2 4
MIRT639660 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT640200 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT641592 TNS4 tensin 4 2 2
MIRT644993 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT645059 UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII 2 2
MIRT646948 UPK3BL uroplakin 3B like 1 2 2
MIRT647306 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT648300 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 4
MIRT649043 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649884 SLFN12L schlafen family member 12 like 2 2
MIRT650196 DOCK7 dedicator of cytokinesis 7 2 2
MIRT654789 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT655667 NUP43 nucleoporin 43 2 2
MIRT655925 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656433 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT657713 GPC4 glypican 4 2 2
MIRT659302 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT659844 CAPZB capping actin protein of muscle Z-line beta subunit 2 2
MIRT660660 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT661308 CPM carboxypeptidase M 2 2
MIRT661473 CHMP1B charged multivesicular body protein 1B 2 2
MIRT661906 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT662064 ZNF284 zinc finger protein 284 2 2
MIRT662491 ANGPT4 angiopoietin 4 2 2
MIRT662657 LRRC47 leucine rich repeat containing 47 2 2
MIRT662804 MSRB2 methionine sulfoxide reductase B2 2 2
MIRT663164 FGFR1OP FGFR1 oncogene partner 2 2
MIRT663376 ZNF770 zinc finger protein 770 2 4
MIRT663418 ZNF607 zinc finger protein 607 2 2
MIRT663990 WDR75 WD repeat domain 75 2 2
MIRT664157 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 4
MIRT664489 POLR3K RNA polymerase III subunit K 2 2
MIRT665058 CCDC77 coiled-coil domain containing 77 2 2
MIRT665080 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT665420 WDR55 WD repeat domain 55 2 2
MIRT665716 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT665923 TBC1D19 TBC1 domain family member 19 2 4
MIRT666239 SLC38A7 solute carrier family 38 member 7 2 4
MIRT666840 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT667378 MOB1B MOB kinase activator 1B 2 2
MIRT667573 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667894 ING1 inhibitor of growth family member 1 2 2
MIRT667977 HECTD3 HECT domain E3 ubiquitin protein ligase 3 2 2
MIRT668197 GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2 2
MIRT668279 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT668386 FAT3 FAT atypical cadherin 3 2 2
MIRT668444 FAM208A family with sequence similarity 208 member A 2 2
MIRT668998 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT669180 CCNF cyclin F 2 2
MIRT669444 ATL3 atlastin GTPase 3 2 2
MIRT669661 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2 2
MIRT669890 KIAA0754 KIAA0754 2 4
MIRT669973 SSR3 signal sequence receptor subunit 3 2 2
MIRT670153 SLC29A4 solute carrier family 29 member 4 2 2
MIRT670240 TRIM13 tripartite motif containing 13 2 2
MIRT670274 CBY3 chibby family member 3 2 2
MIRT670358 ULBP3 UL16 binding protein 3 2 4
MIRT670627 BVES blood vessel epicardial substance 2 2
MIRT670731 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670770 TRIM66 tripartite motif containing 66 2 2
MIRT670913 DESI1 desumoylating isopeptidase 1 2 2
MIRT671216 CLSTN1 calsyntenin 1 2 2
MIRT671398 ERCC6L2 ERCC excision repair 6 like 2 2 2
MIRT671427 TOX4 TOX high mobility group box family member 4 2 2
MIRT671654 TRUB2 TruB pseudouridine synthase family member 2 2 4
MIRT671702 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT672136 PLEKHH1 pleckstrin homology, MyTH4 and FERM domain containing H1 2 2
MIRT672395 SLC10A6 solute carrier family 10 member 6 2 2
MIRT672508 GGCX gamma-glutamyl carboxylase 2 2
MIRT672572 RNF24 ring finger protein 24 2 2
MIRT672789 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT673019 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT673190 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT673372 ZNF124 zinc finger protein 124 2 2
MIRT673495 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT673852 CAPN7 calpain 7 2 2
MIRT673929 ZNF500 zinc finger protein 500 2 2
MIRT673986 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT674076 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674123 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT674297 THAP5 THAP domain containing 5 2 2
MIRT674370 POLR3D RNA polymerase III subunit D 2 2
MIRT674641 NKRF NFKB repressing factor 2 2
MIRT674665 PLCE1 phospholipase C epsilon 1 2 2
MIRT674725 ZNF451 zinc finger protein 451 2 4
MIRT674779 NPR1 natriuretic peptide receptor 1 2 2
MIRT674889 RASSF9 Ras association domain family member 9 2 2
MIRT675017 SNX1 sorting nexin 1 2 2
MIRT675341 KLHL26 kelch like family member 26 2 2
MIRT675416 CLEC7A C-type lectin domain containing 7A 2 2
MIRT675497 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT675615 EHD2 EH domain containing 2 2 2
MIRT675735 AHR aryl hydrocarbon receptor 2 2
MIRT675857 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT675990 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676213 TMEM91 transmembrane protein 91 2 2
MIRT676406 MRO maestro 2 2
MIRT677299 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT677387 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT677859 ABI2 abl interactor 2 2 2
MIRT677965 ITGB3 integrin subunit beta 3 2 2
MIRT678175 CRCP CGRP receptor component 2 2
MIRT678273 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT678665 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT679003 TTC39B tetratricopeptide repeat domain 39B 2 2
MIRT679053 RMDN1 regulator of microtubule dynamics 1 2 2
MIRT679461 RHOF ras homolog family member F, filopodia associated 2 2
MIRT679513 RAB36 RAB36, member RAS oncogene family 2 2
MIRT679914 ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2 2
MIRT680029 OSBPL2 oxysterol binding protein like 2 2 4
MIRT680245 NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 2 2
MIRT680279 AKIP1 A-kinase interacting protein 1 2 2
MIRT680499 PRIM2 DNA primase subunit 2 2 2
MIRT680586 ZNF573 zinc finger protein 573 2 2
MIRT680629 KIAA1456 KIAA1456 2 2
MIRT680819 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT680998 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT681122 INTS7 integrator complex subunit 7 2 2
MIRT681161 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT681221 DUSP19 dual specificity phosphatase 19 2 2
MIRT681304 IKZF3 IKAROS family zinc finger 3 2 2
MIRT681341 BRI3BP BRI3 binding protein 2 2
MIRT681608 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT681779 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681892 SLC11A2 solute carrier family 11 member 2 2 2
MIRT682084 ITGA3 integrin subunit alpha 3 2 4
MIRT682139 SMS spermine synthase 2 2
MIRT682217 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682367 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682535 EXOSC2 exosome component 2 2 2
MIRT682618 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT683643 ZNF695 zinc finger protein 695 2 2
MIRT684008 FOLR1 folate receptor 1 2 2
MIRT684442 MFSD4 major facilitator superfamily domain containing 4A 2 2
MIRT684855 ZNF749 zinc finger protein 749 2 2
MIRT684956 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT685044 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685095 DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2 2
MIRT685382 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT685456 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT685810 SLC27A1 solute carrier family 27 member 1 2 2
MIRT685913 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686665 TMEM120B transmembrane protein 120B 2 2
MIRT686955 SFT2D2 SFT2 domain containing 2 2 2
MIRT687118 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT687739 KIAA1328 KIAA1328 2 2
MIRT688063 GLUL glutamate-ammonia ligase 2 2
MIRT688191 FNIP1 folliculin interacting protein 1 2 2
MIRT688769 CDH7 cadherin 7 2 2
MIRT688979 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT689572 NUDT7 nudix hydrolase 7 2 2
MIRT689683 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT689930 MANSC1 MANSC domain containing 1 2 2
MIRT690089 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT690190 C5orf45 MRN complex interacting protein 2 2
MIRT690246 CAMLG calcium modulating ligand 2 2
MIRT690411 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT690840 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT690889 FUT2 fucosyltransferase 2 2 2
MIRT691107 ADIPOQ adiponectin, C1Q and collagen domain containing 2 2
MIRT691229 DFNB59 pejvakin 2 2
MIRT691300 ZNF681 zinc finger protein 681 2 2
MIRT691366 GP5 glycoprotein V platelet 2 2
MIRT691797 WARS tryptophanyl-tRNA synthetase 2 2
MIRT692142 CEP104 centrosomal protein 104 2 2
MIRT692572 NCMAP non-compact myelin associated protein 2 2
MIRT692649 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT692744 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 2 2
MIRT693092 SCNM1 sodium channel modifier 1 2 2
MIRT693296 SYTL3 synaptotagmin like 3 2 2
MIRT693392 ZNF460 zinc finger protein 460 2 2
MIRT693530 ZNF708 zinc finger protein 708 2 2
MIRT693562 PIGR polymeric immunoglobulin receptor 2 2
MIRT694492 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT694722 LLGL1 LLGL1, scribble cell polarity complex component 2 2
MIRT694866 ZNF417 zinc finger protein 417 2 2
MIRT695070 ZNF17 zinc finger protein 17 2 2
MIRT695451 COX18 COX18, cytochrome c oxidase assembly factor 2 2
MIRT695724 ZNF117 zinc finger protein 117 2 2
MIRT695898 MED16 mediator complex subunit 16 2 2
MIRT696244 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT696259 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT696512 C3 complement C3 2 2
MIRT696560 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696643 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696791 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT696819 PLLP plasmolipin 2 2
MIRT697088 GPKOW G-patch domain and KOW motifs 2 2
MIRT697153 INMT indolethylamine N-methyltransferase 2 2
MIRT697202 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT697322 ZNF641 zinc finger protein 641 2 2
MIRT697578 YME1L1 YME1 like 1 ATPase 2 2
MIRT697619 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT698619 TES testin LIM domain protein 2 2
MIRT698804 STK38 serine/threonine kinase 38 2 2
MIRT698949 SPAST spastin 2 2
MIRT699083 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT699430 SLC1A5 solute carrier family 1 member 5 2 2
MIRT699550 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT700324 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT700360 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT700462 PURB purine rich element binding protein B 2 2
MIRT701677 MYADM myeloid associated differentiation marker 2 2
MIRT701757 MSL2 MSL complex subunit 2 2 2
MIRT701977 MIER3 MIER family member 3 2 2
MIRT703178 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT703203 GOLGA3 golgin A3 2 2
MIRT703359 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT703425 FYTTD1 forty-two-three domain containing 1 2 2
MIRT703484 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT703590 FBXO45 F-box protein 45 2 2
MIRT703806 EVI5 ecotropic viral integration site 5 2 2
MIRT703915 EPG5 ectopic P-granules autophagy protein 5 homolog 2 2
MIRT704234 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704646 CLCC1 chloride channel CLIC like 1 2 2
MIRT705151 C11orf58 chromosome 11 open reading frame 58 2 2
MIRT705480 ASXL2 additional sex combs like 2, transcriptional regulator 2 2
MIRT705530 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT705661 ANKRD40 ankyrin repeat domain 40 2 2
MIRT706144 ZNF674 zinc finger protein 674 2 2
MIRT706473 SNX27 sorting nexin family member 27 2 2
MIRT708254 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT708838 SCAND3 zinc finger BED-type containing 9 1 1
MIRT710437 BTNL3 butyrophilin like 3 2 2
MIRT711325 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT716151 RBM48 RNA binding motif protein 48 2 2
MIRT717402 ZCCHC24 zinc finger CCHC-type containing 24 2 2
MIRT720866 ADCY5 adenylate cyclase 5 2 2
MIRT722226 ZNF503 zinc finger protein 503 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1273h-5p Paclitaxel 36314 NSC125973 approved sensitive High Ovarian Cancer cell line (SKOV3)
hsa-miR-1273h-5p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-1273h-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

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