pre-miRNA Information
pre-miRNA hsa-mir-1273h   
Genomic Coordinates chr16: 24203116 - 24203231
Description Homo sapiens miR-1273h stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1273h-5p
Sequence 33| CUGGGAGGUCAAGGCUGCAGU |53
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1028034199 14 dbSNP
rs542383563 18 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol IGSF6   
Synonyms DORA
Description immunoglobulin superfamily member 6
Transcript NM_005849   
Expression
Putative miRNA Targets on IGSF6
3'UTR of IGSF6
(miRNA target sites are highlighted)
>IGSF6|NM_005849|3'UTR
   1 AAACGTTTTAATTTTCAATGAAGTCACTGAAAATCCAACTCCAGGAGCTATGGCAGTGTTAATGAACATATATCATCAGG
  81 TCTTAAAAAAAAATAAAGGTAAACTGAAAAGACAACTGGCTACAAAGAAGGATGTCAGAATGTAAGGAAACTATAACTAA
 161 TAGTCATTACCAAAATACTAAAACCCAACAAAATGCAACTGAAAAATACCTTCCAAATTTGCCAAGAAAAAAAATTCTAT
 241 TTTAAACTTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugACGUCGGAAC------UGGAGGGUc 5'
            |||| |  ||      ||||:||| 
Target 5' aaTGCAAC--TGAAAAATACCTTCCAa 3'
192 - 216 133.00 -13.34
2
miRNA  3' ugacgucggaacugGAGGguc 5'
                        ||||   
Target 5' cactgaaaatccaaCTCCagg 3'
25 - 45 80.00 -10.21
3
miRNA  3' ugacguCGGAACUGGAGGGUc 5'
                |::|| |::|:| | 
Target 5' --aaacGTTTTAATTTTCAAt 3'
1 - 19 79.00 -5.12
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20078507 4 COSMIC
COSN20072033 19 COSMIC
COSN31598864 34 COSMIC
COSN30517283 35 COSMIC
COSN30453966 41 COSMIC
COSN31560331 78 COSMIC
COSN18739308 85 COSMIC
COSN31559671 116 COSMIC
COSN30510526 139 COSMIC
COSN22839472 165 COSMIC
COSN30177408 199 COSMIC
COSN28846043 227 COSMIC
COSN8494663 296 COSMIC
COSN20994526 363 COSMIC
COSN1694874 417 COSMIC
COSN22588595 465 COSMIC
COSN20967684 484 COSMIC
COSN4764766 1120 COSMIC
COSN8494662 1453 COSMIC
COSN8818062 1515 COSMIC
COSN27222995 1577 COSMIC
COSN6081572 1827 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs374066910 5 dbSNP
rs747031982 9 dbSNP
rs1375458445 10 dbSNP
rs779697190 11 dbSNP
rs1435751746 16 dbSNP
rs534128276 17 dbSNP
rs750192058 19 dbSNP
rs779729579 23 dbSNP
rs1456619438 26 dbSNP
rs1365734196 27 dbSNP
rs1248192426 34 dbSNP
rs1160039781 35 dbSNP
rs778501363 39 dbSNP
rs756929837 44 dbSNP
rs368983016 45 dbSNP
rs763634011 49 dbSNP
rs1368442805 54 dbSNP
rs937833081 70 dbSNP
rs1167678127 77 dbSNP
rs1410240182 85 dbSNP
rs1420665066 91 dbSNP
rs141804055 94 dbSNP
rs926447978 94 dbSNP
rs974246948 95 dbSNP
rs962473796 101 dbSNP
rs540497585 104 dbSNP
rs1333555799 105 dbSNP
rs1341099511 109 dbSNP
rs1245460206 111 dbSNP
rs1294991231 113 dbSNP
rs1326825232 118 dbSNP
rs1227553579 119 dbSNP
rs1268437348 123 dbSNP
rs1486632484 134 dbSNP
rs1055740 135 dbSNP
rs1482025282 143 dbSNP
rs1250159962 147 dbSNP
rs1472506060 160 dbSNP
rs1160349650 161 dbSNP
rs978673888 161 dbSNP
rs982410809 162 dbSNP
rs1212583293 173 dbSNP
rs1464761281 186 dbSNP
rs1249775769 194 dbSNP
rs1403020591 207 dbSNP
rs955002427 208 dbSNP
rs551517278 225 dbSNP
rs997028280 231 dbSNP
rs1318458697 232 dbSNP
rs1230633820 235 dbSNP
rs909938043 247 dbSNP
rs984627909 251 dbSNP
rs951818297 274 dbSNP
rs1273179258 277 dbSNP
rs1483002120 282 dbSNP
rs1183483630 284 dbSNP
rs558052609 286 dbSNP
rs1242811277 287 dbSNP
rs533443477 289 dbSNP
rs773732213 294 dbSNP
rs1349842551 301 dbSNP
rs1289358171 306 dbSNP
rs974650175 308 dbSNP
rs965989008 321 dbSNP
rs1368678420 332 dbSNP
rs569223217 338 dbSNP
rs1000719192 350 dbSNP
rs1304416246 351 dbSNP
rs1375268654 353 dbSNP
rs903257050 355 dbSNP
rs149283702 364 dbSNP
rs950032971 379 dbSNP
rs762276391 384 dbSNP
rs1271821084 392 dbSNP
rs746284769 397 dbSNP
rs774572609 402 dbSNP
rs1291436730 403 dbSNP
rs1455020755 408 dbSNP
rs1253529050 409 dbSNP
rs529402848 414 dbSNP
rs1487748826 416 dbSNP
rs1345631394 417 dbSNP
rs1158118162 420 dbSNP
rs1010620033 421 dbSNP
rs1369094743 423 dbSNP
rs895312918 427 dbSNP
rs1056408094 435 dbSNP
rs1389650764 443 dbSNP
rs937886844 450 dbSNP
rs926473257 456 dbSNP
rs973919566 463 dbSNP
rs1171063383 467 dbSNP
rs941146876 470 dbSNP
rs143500893 491 dbSNP
rs748881788 492 dbSNP
rs1292707909 493 dbSNP
rs182308969 494 dbSNP
rs1266754117 498 dbSNP
rs1208342991 504 dbSNP
rs1294875336 507 dbSNP
rs144638064 509 dbSNP
rs1269201036 512 dbSNP
rs1214643588 520 dbSNP
rs955055583 522 dbSNP
rs1320425047 524 dbSNP
rs528803134 525 dbSNP
rs774984789 532 dbSNP
rs1470063673 533 dbSNP
rs1327462605 534 dbSNP
rs940012422 539 dbSNP
rs1285767682 542 dbSNP
rs909874208 547 dbSNP
rs1465451868 557 dbSNP
rs1234519324 558 dbSNP
rs1330072917 561 dbSNP
rs922250307 568 dbSNP
rs975661156 569 dbSNP
rs1421625582 572 dbSNP
rs1421953796 575 dbSNP
rs1048437658 578 dbSNP
rs1418324254 580 dbSNP
rs1462759100 582 dbSNP
rs932756456 592 dbSNP
rs921758580 593 dbSNP
rs560080016 605 dbSNP
rs1430891842 606 dbSNP
rs964317598 610 dbSNP
rs1376298782 611 dbSNP
rs965882847 619 dbSNP
rs1455467385 621 dbSNP
rs751501132 624 dbSNP
rs1226937189 626 dbSNP
rs1267804572 633 dbSNP
rs1033631810 634 dbSNP
rs533729416 637 dbSNP
rs1218087646 638 dbSNP
rs1235836443 646 dbSNP
rs911790740 649 dbSNP
rs978417447 663 dbSNP
rs1258136131 667 dbSNP
rs1476099481 669 dbSNP
rs1465469959 674 dbSNP
rs1410823317 675 dbSNP
rs149376696 680 dbSNP
rs1160785110 689 dbSNP
rs34236597 691 dbSNP
rs1000364239 695 dbSNP
rs1446556871 696 dbSNP
rs1010611872 698 dbSNP
rs1357900314 706 dbSNP
rs967908516 707 dbSNP
rs1020374406 717 dbSNP
rs959140221 718 dbSNP
rs1225706477 723 dbSNP
rs1276685053 724 dbSNP
rs1033797575 732 dbSNP
rs1211671956 734 dbSNP
rs1281016601 735 dbSNP
rs1486595050 738 dbSNP
rs1014317931 741 dbSNP
rs1440617237 744 dbSNP
rs200657608 744 dbSNP
rs1470359335 745 dbSNP
rs1003636148 746 dbSNP
rs1413466517 746 dbSNP
rs1422612744 746 dbSNP
rs1344897497 747 dbSNP
rs1253779541 749 dbSNP
rs1307908260 750 dbSNP
rs1229021432 751 dbSNP
rs1444811495 754 dbSNP
rs1235166413 756 dbSNP
rs1273355694 756 dbSNP
rs1367142121 756 dbSNP
rs1305755350 757 dbSNP
rs1365230933 762 dbSNP
rs1296437118 767 dbSNP
rs1202948091 768 dbSNP
rs1272128033 768 dbSNP
rs368164205 768 dbSNP
rs371243536 768 dbSNP
rs1193836961 769 dbSNP
rs1432359551 769 dbSNP
rs1396386550 774 dbSNP
rs1384793585 780 dbSNP
rs1167914370 781 dbSNP
rs1397819793 784 dbSNP
rs906711066 790 dbSNP
rs1321950639 796 dbSNP
rs1334535480 798 dbSNP
rs1395421494 803 dbSNP
rs1400014879 804 dbSNP
rs1328099916 809 dbSNP
rs1363117383 812 dbSNP
rs1227764564 813 dbSNP
rs1169526808 814 dbSNP
rs1431718952 818 dbSNP
rs1339971155 819 dbSNP
rs1216153932 827 dbSNP
rs1287509670 833 dbSNP
rs1467828442 836 dbSNP
rs1213943697 839 dbSNP
rs1463205735 842 dbSNP
rs1191817158 843 dbSNP
rs1374184943 847 dbSNP
rs1037244082 853 dbSNP
rs895837969 855 dbSNP
rs1416489273 861 dbSNP
rs1055784181 874 dbSNP
rs1417605619 892 dbSNP
rs1462230047 893 dbSNP
rs6497559 895 dbSNP
rs1447875810 896 dbSNP
rs1173428544 897 dbSNP
rs992546266 899 dbSNP
rs1328237816 901 dbSNP
rs1432835746 906 dbSNP
rs535857273 907 dbSNP
rs1048464961 909 dbSNP
rs1188643676 910 dbSNP
rs1442166023 911 dbSNP
rs932703983 911 dbSNP
rs62044199 915 dbSNP
rs1254718421 916 dbSNP
rs1326604136 917 dbSNP
rs62835763 917 dbSNP
rs1204143442 930 dbSNP
rs1198017318 935 dbSNP
rs1342265704 937 dbSNP
rs1167525234 938 dbSNP
rs1186049898 938 dbSNP
rs1257421899 938 dbSNP
rs1410088031 938 dbSNP
rs1448161102 938 dbSNP
rs1475774721 938 dbSNP
rs368761095 938 dbSNP
rs377748479 938 dbSNP
rs796253756 938 dbSNP
rs1273282956 939 dbSNP
rs1311053861 939 dbSNP
rs8050882 939 dbSNP
rs1033995650 940 dbSNP
rs1415212116 940 dbSNP
rs1225782830 941 dbSNP
rs1237889657 945 dbSNP
rs1260878298 946 dbSNP
rs1361110094 946 dbSNP
rs1284380115 947 dbSNP
rs57574077 950 dbSNP
rs59715115 952 dbSNP
rs577588612 954 dbSNP
rs1338423279 955 dbSNP
rs555953460 958 dbSNP
rs1250096798 962 dbSNP
rs146415056 963 dbSNP
rs1371306510 976 dbSNP
rs1182804680 985 dbSNP
rs573834898 986 dbSNP
rs1428107631 989 dbSNP
rs1416270575 990 dbSNP
rs1173051227 996 dbSNP
rs944517673 997 dbSNP
rs905100995 998 dbSNP
rs146372127 1003 dbSNP
rs781241411 1005 dbSNP
rs151096602 1006 dbSNP
rs945327803 1014 dbSNP
rs757113307 1021 dbSNP
rs528018787 1023 dbSNP
rs1337143557 1031 dbSNP
rs1231497525 1032 dbSNP
rs1185060666 1035 dbSNP
rs1302103508 1036 dbSNP
rs1347913494 1038 dbSNP
rs1213663029 1040 dbSNP
rs754546552 1043 dbSNP
rs933725633 1044 dbSNP
rs1250476383 1045 dbSNP
rs117115217 1046 dbSNP
rs959045942 1048 dbSNP
rs975043334 1055 dbSNP
rs964683018 1056 dbSNP
rs1290166203 1057 dbSNP
rs970883811 1058 dbSNP
rs1461341628 1059 dbSNP
rs59234859 1062 dbSNP
rs534600431 1063 dbSNP
rs926225983 1069 dbSNP
rs1398315417 1075 dbSNP
rs777698477 1102 dbSNP
rs1228983734 1107 dbSNP
rs1324734724 1110 dbSNP
rs1371100534 1110 dbSNP
rs559793643 1111 dbSNP
rs1235846473 1114 dbSNP
rs967582588 1116 dbSNP
rs1294131903 1119 dbSNP
rs1349767329 1132 dbSNP
rs1020440646 1133 dbSNP
rs1014370403 1144 dbSNP
rs530360228 1166 dbSNP
rs1228744082 1169 dbSNP
rs1408102677 1178 dbSNP
rs1351635398 1181 dbSNP
rs1324464942 1184 dbSNP
rs1487675935 1185 dbSNP
rs1004465560 1188 dbSNP
rs888719874 1194 dbSNP
rs1026973297 1199 dbSNP
rs558053450 1210 dbSNP
rs372993277 1212 dbSNP
rs1259627109 1213 dbSNP
rs1427885111 1217 dbSNP
rs1171003675 1218 dbSNP
rs899837312 1219 dbSNP
rs755269582 1227 dbSNP
rs1473099020 1233 dbSNP
rs1163847512 1243 dbSNP
rs778857819 1262 dbSNP
rs899127639 1269 dbSNP
rs1360601380 1270 dbSNP
rs1478726607 1287 dbSNP
rs1038304298 1291 dbSNP
rs1383281512 1293 dbSNP
rs1005858764 1295 dbSNP
rs886971517 1300 dbSNP
rs1046868666 1301 dbSNP
rs1449490695 1307 dbSNP
rs570669467 1309 dbSNP
rs933779648 1311 dbSNP
rs922355344 1316 dbSNP
rs539414921 1317 dbSNP
rs555465246 1320 dbSNP
rs1241621533 1325 dbSNP
rs9921724 1330 dbSNP
rs979053963 1331 dbSNP
rs1187044658 1332 dbSNP
rs1263760636 1341 dbSNP
rs1474136797 1347 dbSNP
rs946272182 1353 dbSNP
rs1418254597 1357 dbSNP
rs913430023 1358 dbSNP
rs945301354 1360 dbSNP
rs1344095147 1369 dbSNP
rs1286399483 1374 dbSNP
rs1453845644 1375 dbSNP
rs915132270 1378 dbSNP
rs1225201207 1381 dbSNP
rs1354084981 1387 dbSNP
rs550611921 1392 dbSNP
rs1275501703 1393 dbSNP
rs559891156 1396 dbSNP
rs1222297247 1403 dbSNP
rs937636370 1404 dbSNP
rs1034442791 1405 dbSNP
rs148965577 1409 dbSNP
rs980565051 1410 dbSNP
rs963430005 1413 dbSNP
rs1288137175 1419 dbSNP
rs1484632573 1420 dbSNP
rs1322746791 1427 dbSNP
rs540488106 1428 dbSNP
rs981817515 1429 dbSNP
rs970922207 1430 dbSNP
rs1015742706 1434 dbSNP
rs1406771949 1435 dbSNP
rs1016660910 1440 dbSNP
rs983383453 1444 dbSNP
rs1373059380 1447 dbSNP
rs1157675818 1465 dbSNP
rs1434670591 1468 dbSNP
rs952922821 1477 dbSNP
rs1377659531 1479 dbSNP
rs1416640981 1480 dbSNP
rs1440465024 1483 dbSNP
rs1279253585 1487 dbSNP
rs771476404 1490 dbSNP
rs1225577560 1492 dbSNP
rs1301365983 1494 dbSNP
rs1347169743 1496 dbSNP
rs1027201118 1499 dbSNP
rs1280947542 1502 dbSNP
rs530684228 1505 dbSNP
rs1476733946 1507 dbSNP
rs1480770677 1508 dbSNP
rs1372747172 1509 dbSNP
rs568309934 1510 dbSNP
rs1174895852 1513 dbSNP
rs1397418967 1515 dbSNP
rs1188736877 1520 dbSNP
rs887021130 1521 dbSNP
rs563053094 1522 dbSNP
rs1464279648 1525 dbSNP
rs1266007102 1526 dbSNP
rs546827025 1534 dbSNP
rs1025474099 1535 dbSNP
rs528739985 1540 dbSNP
rs1346995908 1542 dbSNP
rs1212691507 1555 dbSNP
rs190801452 1556 dbSNP
rs1307805225 1566 dbSNP
rs1039439884 1575 dbSNP
rs200834716 1578 dbSNP
rs1041821552 1604 dbSNP
rs1342884634 1605 dbSNP
rs1053595395 1609 dbSNP
rs113376697 1609 dbSNP
rs1193689689 1609 dbSNP
rs1441780824 1609 dbSNP
rs893640647 1609 dbSNP
rs945182540 1609 dbSNP
rs1328040678 1610 dbSNP
rs942418017 1611 dbSNP
rs1269458687 1614 dbSNP
rs1436082625 1614 dbSNP
rs1339914488 1618 dbSNP
rs904211192 1620 dbSNP
rs1043101351 1627 dbSNP
rs1364996108 1628 dbSNP
rs946352912 1629 dbSNP
rs1270938292 1643 dbSNP
rs913482523 1645 dbSNP
rs1333665112 1648 dbSNP
rs187303224 1653 dbSNP
rs1291432689 1655 dbSNP
rs993046613 1659 dbSNP
rs926287592 1666 dbSNP
rs34524474 1667 dbSNP
rs879369490 1667 dbSNP
rs1450862749 1672 dbSNP
rs1243185572 1677 dbSNP
rs1479033350 1689 dbSNP
rs1186212875 1691 dbSNP
rs376579089 1693 dbSNP
rs1462183511 1705 dbSNP
rs750437091 1709 dbSNP
rs1175918955 1711 dbSNP
rs1382890858 1713 dbSNP
rs1412273813 1723 dbSNP
rs908259526 1724 dbSNP
rs982555825 1731 dbSNP
rs532751773 1740 dbSNP
rs1168916185 1746 dbSNP
rs562507415 1750 dbSNP
rs1291246685 1762 dbSNP
rs975660238 1766 dbSNP
rs1183408763 1767 dbSNP
rs1016302566 1773 dbSNP
rs983856989 1775 dbSNP
rs1483425253 1776 dbSNP
rs377465939 1785 dbSNP
rs1347994934 1791 dbSNP
rs964314878 1792 dbSNP
rs1019615347 1800 dbSNP
rs950682929 1802 dbSNP
rs367571837 1803 dbSNP
rs1209293313 1806 dbSNP
rs1025521704 1819 dbSNP
rs998027814 1821 dbSNP
rs573814599 1822 dbSNP
rs1475703312 1823 dbSNP
rs1189961947 1824 dbSNP
rs555577638 1831 dbSNP
rs1469738830 1832 dbSNP
rs1018504249 1833 dbSNP
rs1159188138 1834 dbSNP
rs1421468203 1834 dbSNP
rs1020746941 1836 dbSNP
rs1011667213 1838 dbSNP
rs1396376770 1841 dbSNP
rs576447641 1847 dbSNP
rs1314491184 1849 dbSNP
rs1333588204 1859 dbSNP
rs893630882 1860 dbSNP
rs904262631 1866 dbSNP
rs374132596 1868 dbSNP
rs867440804 1869 dbSNP
rs1202525424 1870 dbSNP
rs1248734585 1873 dbSNP
rs1437495927 1877 dbSNP
rs1182743236 1894 dbSNP
rs1276848252 1895 dbSNP
rs945697090 1897 dbSNP
rs1229473585 1898 dbSNP
rs1466394730 1905 dbSNP
rs905145862 1906 dbSNP
rs891438600 1924 dbSNP
rs1293651411 1925 dbSNP
rs1230412065 1932 dbSNP
rs1331526639 1938 dbSNP
rs1390473292 1938 dbSNP
rs1005127462 1945 dbSNP
rs1057407647 1952 dbSNP
rs573007651 1954 dbSNP
rs1438063512 1955 dbSNP
rs1046323789 1956 dbSNP
rs1313271133 1960 dbSNP
rs890273293 1963 dbSNP
rs772359251 1985 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084074. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUUACAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000268389.4 | 3UTR | AAUGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000268389.4 | 3UTR | UGAAAUGGCCUCCCAAAGUGCUGGGAUUACAGGCGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000268389.4 | 3UTR | AAAUGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000268389.4 | 3UTR | AAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUUACAGGCGUGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000268389.4 | 3UTR | UGAAAUGGCCUCCCAAAGUGCUGGGAUUACAGGCGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000268389.4 | 3UTR | GAAAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084074
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SantaCruzAb
Location of target site ENST00000268389.4 | 3UTR | AAAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000268389.4 | 3UTR | AAAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000268389.4 | 3UTR | AAUGGCCUCCCAAAGUGCUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
494 hsa-miR-1273h-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT074355 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT100721 TJAP1 tight junction associated protein 1 2 2
MIRT115545 MAZ MYC associated zinc finger protein 2 2
MIRT124982 XIAP X-linked inhibitor of apoptosis 2 4
MIRT139911 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT177183 ARL5B ADP ribosylation factor like GTPase 5B 2 4
MIRT187994 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT207410 MAT2A methionine adenosyltransferase 2A 2 6
MIRT241928 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT260110 KLHL21 kelch like family member 21 2 2
MIRT260358 XRCC6 X-ray repair cross complementing 6 2 6
MIRT266428 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT294663 ZNF548 zinc finger protein 548 2 2
MIRT351039 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT379943 PRRG4 proline rich and Gla domain 4 2 2
MIRT398983 KAT7 lysine acetyltransferase 7 2 2
MIRT441465 BEST3 bestrophin 3 2 2
MIRT446750 ZNF491 zinc finger protein 491 2 2
MIRT449224 RAD51B RAD51 paralog B 2 2
MIRT450623 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT451090 ZNF584 zinc finger protein 584 2 2
MIRT451558 CIAPIN1 cytokine induced apoptosis inhibitor 1 2 2
MIRT451736 CES3 carboxylesterase 3 2 2
MIRT452411 QDPR quinoid dihydropteridine reductase 2 2
MIRT452559 ZFP69B ZFP69 zinc finger protein B 2 2
MIRT452851 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT452922 DISC1 disrupted in schizophrenia 1 2 2
MIRT453043 TANGO2 transport and golgi organization 2 homolog 2 4
MIRT453097 HOXC4 homeobox C4 2 2
MIRT453297 ZNF394 zinc finger protein 394 2 2
MIRT453593 ZNF557 zinc finger protein 557 2 2
MIRT453787 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT453987 CECR1 adenosine deaminase 2 2 2
MIRT454083 TMEM209 transmembrane protein 209 2 2
MIRT454652 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT454753 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2 2
MIRT455311 TTLL9 tubulin tyrosine ligase like 9 2 2
MIRT456468 SERAC1 serine active site containing 1 2 2
MIRT456554 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT456716 TMEM239 transmembrane protein 239 2 4
MIRT456796 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT457487 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457999 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458130 TLCD2 TLC domain containing 2 2 2
MIRT459027 ZNF490 zinc finger protein 490 2 4
MIRT459119 FADS6 fatty acid desaturase 6 2 2
MIRT459315 HAVCR2 hepatitis A virus cellular receptor 2 2 2
MIRT459385 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT459412 FAM83B family with sequence similarity 83 member B 2 2
MIRT459974 RFT1 RFT1 homolog 2 2
MIRT460480 FAM105A family with sequence similarity 105 member A 2 6
MIRT460586 FEM1A fem-1 homolog A 2 2
MIRT460920 NOA1 nitric oxide associated 1 2 4
MIRT461072 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461590 DPH2 DPH2 homolog 2 2
MIRT461854 ZNF317 zinc finger protein 317 2 2
MIRT462176 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT462446 GCDH glutaryl-CoA dehydrogenase 2 2
MIRT463854 WNT7B Wnt family member 7B 2 2
MIRT464310 UST uronyl 2-sulfotransferase 2 2
MIRT464815 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT465453 TOR2A torsin family 2 member A 2 2
MIRT466073 TMEM184C transmembrane protein 184C 2 2
MIRT466514 TBXA2R thromboxane A2 receptor 2 2
MIRT467072 SRRD SRR1 domain containing 2 2
MIRT469551 RARA retinoic acid receptor alpha 2 2
MIRT469741 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT470759 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT470875 PLXND1 plexin D1 2 2
MIRT470976 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT471048 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2 2
MIRT471215 PHAX phosphorylated adaptor for RNA export 2 2
MIRT471246 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471286 PGAM4 phosphoglycerate mutase family member 4 2 2
MIRT471467 PDE7B phosphodiesterase 7B 2 2
MIRT473069 MORN4 MORN repeat containing 4 2 4
MIRT473989 LRRC20 leucine rich repeat containing 20 2 2
MIRT474518 KLHDC8A kelch domain containing 8A 2 2
MIRT474990 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT475547 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 2
MIRT476350 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT477298 EPHB2 EPH receptor B2 2 2
MIRT477933 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478282 DDX19A DEAD-box helicase 19A 2 4
MIRT478472 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT478559 CTNND1 catenin delta 1 2 2
MIRT478618 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT478834 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT479007 COL5A1 collagen type V alpha 1 chain 2 2
MIRT479166 CLSPN claspin 2 2
MIRT482454 ADAR adenosine deaminase, RNA specific 2 4
MIRT483019 KHSRP KH-type splicing regulatory protein 2 4
MIRT483798 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT486087 SLC7A5 solute carrier family 7 member 5 2 4
MIRT486304 SIPA1 signal-induced proliferation-associated 1 2 2
MIRT486490 MYH11 myosin heavy chain 11 2 2
MIRT486881 TSPYL4 TSPY like 4 2 2
MIRT487125 NCOR2 nuclear receptor corepressor 2 2 2
MIRT487542 TM6SF2 transmembrane 6 superfamily member 2 2 4
MIRT487676 B3GALT5 beta-1,3-galactosyltransferase 5 2 4
MIRT489251 TTLL1 tubulin tyrosine ligase like 1 2 4
MIRT489276 RBM8A RNA binding motif protein 8A 2 8
MIRT489496 CRLF3 cytokine receptor like factor 3 2 4
MIRT489571 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489694 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT490166 TMEM63C transmembrane protein 63C 2 2
MIRT491199 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT491260 DHX40 DEAH-box helicase 40 2 2
MIRT491385 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT491548 YAE1D1 Yae1 domain containing 1 2 2
MIRT492722 PHF12 PHD finger protein 12 2 2
MIRT493866 FAM73B mitoguardin 2 2 4
MIRT494549 BAK1 BCL2 antagonist/killer 1 2 2
MIRT498586 KRT8 keratin 8 2 2
MIRT498722 SNTN sentan, cilia apical structure protein 2 6
MIRT499982 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT503414 SLC25A45 solute carrier family 25 member 45 2 6
MIRT508491 FTO FTO, alpha-ketoglutarate dependent dioxygenase 2 2
MIRT508877 METTL14 methyltransferase like 14 2 2
MIRT509622 RRP7A ribosomal RNA processing 7 homolog A 2 4
MIRT510104 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT510139 PDGFRA platelet derived growth factor receptor alpha 2 4
MIRT510353 ZNF703 zinc finger protein 703 2 6
MIRT510620 TMEM167A transmembrane protein 167A 2 4
MIRT510786 SF3B3 splicing factor 3b subunit 3 2 6
MIRT511021 NRF1 nuclear respiratory factor 1 2 2
MIRT513925 GHITM growth hormone inducible transmembrane protein 2 2
MIRT514342 DNAH17 dynein axonemal heavy chain 17 2 4
MIRT515015 SUMF2 sulfatase modifying factor 2 2 2
MIRT515246 DUSP28 dual specificity phosphatase 28 2 2
MIRT516202 RPP30 ribonuclease P/MRP subunit p30 2 2
MIRT516435 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT516666 ZNF860 zinc finger protein 860 2 4
MIRT518373 ZNF250 zinc finger protein 250 2 2
MIRT518930 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT519676 ZNF70 zinc finger protein 70 2 2
MIRT519902 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT519945 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT520321 UBXN2A UBX domain protein 2A 2 2
MIRT520606 TMEM41B transmembrane protein 41B 2 2
MIRT520663 TMEM11 transmembrane protein 11 2 2
MIRT520852 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521443 RAD51 RAD51 recombinase 2 2
MIRT521671 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT522281 NKAP NFKB activating protein 2 2
MIRT522333 NCKIPSD NCK interacting protein with SH3 domain 2 8
MIRT522535 MED28 mediator complex subunit 28 2 6
MIRT523478 GNG4 G protein subunit gamma 4 2 2
MIRT523672 FOPNL FGFR1OP N-terminal like 2 2
MIRT523715 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523867 ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2 4
MIRT524043 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT524167 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT524928 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT526825 PHC1 polyhomeotic homolog 1 2 2
MIRT531017 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT536085 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT540681 BMP3 bone morphogenetic protein 3 2 2
MIRT541708 TMEM33 transmembrane protein 33 2 2
MIRT541755 KLF8 Kruppel like factor 8 2 2
MIRT541888 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT545714 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT559054 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT561748 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT562365 ETV3 ETS variant 3 2 2
MIRT562821 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT562900 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT564452 SLC35E2 solute carrier family 35 member E2 2 5
MIRT569111 ONECUT3 one cut homeobox 3 2 2
MIRT569224 SUSD1 sushi domain containing 1 2 2
MIRT570271 ARPC3 actin related protein 2/3 complex subunit 3 2 2
MIRT570498 TFIP11 tuftelin interacting protein 11 2 2
MIRT570844 GPRC5C G protein-coupled receptor class C group 5 member C 2 2
MIRT571311 TPCN2 two pore segment channel 2 2 2
MIRT572077 EXOC8 exocyst complex component 8 2 2
MIRT572116 DNAJC24 DnaJ heat shock protein family (Hsp40) member C24 2 2
MIRT573054 TRIB1 tribbles pseudokinase 1 2 2
MIRT573483 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT573656 HES6 hes family bHLH transcription factor 6 2 2
MIRT574343 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT576494 Slc35e2 solute carrier family 35, member E2 2 4
MIRT608033 UBLCP1 ubiquitin like domain containing CTD phosphatase 1 2 2
MIRT611326 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT613660 KIAA1210 KIAA1210 2 2
MIRT615638 ATF6 activating transcription factor 6 2 2
MIRT618573 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT618865 MBL2 mannose binding lectin 2 2 2
MIRT618962 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT619172 SLC16A4 solute carrier family 16 member 4 2 2
MIRT620298 AQP6 aquaporin 6 2 2
MIRT620683 RFTN2 raftlin family member 2 2 2
MIRT621637 UBXN2B UBX domain protein 2B 2 2
MIRT621993 STK4 serine/threonine kinase 4 2 2
MIRT622421 NUDT19 nudix hydrolase 19 2 2
MIRT622804 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 4
MIRT624786 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT624968 ZNF665 zinc finger protein 665 2 4
MIRT625479 SMAD9 SMAD family member 9 2 2
MIRT626594 ACAA2 acetyl-CoA acyltransferase 2 2 4
MIRT626708 TRIM65 tripartite motif containing 65 2 2
MIRT626975 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT627489 STRIP2 striatin interacting protein 2 2 2
MIRT628505 ZNF878 zinc finger protein 878 2 2
MIRT628533 ZNF701 zinc finger protein 701 2 2
MIRT628591 TMEM251 transmembrane protein 251 2 2
MIRT628818 SLC25A34 solute carrier family 25 member 34 2 2
MIRT628896 IGSF6 immunoglobulin superfamily member 6 2 2
MIRT628958 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 2
MIRT629005 OSBPL10 oxysterol binding protein like 10 2 2
MIRT629059 KIF1C kinesin family member 1C 2 2
MIRT629192 PAPOLA poly(A) polymerase alpha 2 2
MIRT629346 TMPRSS11BNL TMPRSS11B N-terminal like, pseudogene 2 2
MIRT629447 WIZ widely interspaced zinc finger motifs 2 2
MIRT629696 XKR4 XK related 4 2 2
MIRT629737 SCD5 stearoyl-CoA desaturase 5 2 2
MIRT629896 SPATA5 spermatogenesis associated 5 2 2
MIRT629953 GLP2R glucagon like peptide 2 receptor 2 2
MIRT630023 MTL5 testis expressed metallothionein like protein 2 2
MIRT630181 TLN1 talin 1 2 2
MIRT630325 PAQR5 progestin and adipoQ receptor family member 5 2 2
MIRT630389 MYH9 myosin heavy chain 9 2 4
MIRT630695 EXTL3 exostosin like glycosyltransferase 3 2 2
MIRT631054 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT631130 SYNJ2 synaptojanin 2 2 2
MIRT631374 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT631557 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT631615 PCDHB11 protocadherin beta 11 2 2
MIRT631935 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 4
MIRT632109 SSR1 signal sequence receptor subunit 1 2 2
MIRT632168 CCL22 C-C motif chemokine ligand 22 2 2
MIRT632445 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT632652 NAV1 neuron navigator 1 2 2
MIRT632688 MTMR10 myotubularin related protein 10 2 2
MIRT632828 IGF1 insulin like growth factor 1 2 2
MIRT632905 FRRS1 ferric chelate reductase 1 2 2
MIRT633027 DNAL1 dynein axonemal light chain 1 2 2
MIRT633379 FBXW8 F-box and WD repeat domain containing 8 2 2
MIRT633440 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633726 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT633832 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT633862 ATP6V1A ATPase H+ transporting V1 subunit A 2 2
MIRT634042 NUP155 nucleoporin 155 2 2
MIRT634266 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634374 RAP2B RAP2B, member of RAS oncogene family 2 2
MIRT634439 PDE7A phosphodiesterase 7A 2 2
MIRT634573 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT634620 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT634693 DSEL dermatan sulfate epimerase-like 2 2
MIRT634768 CD3D CD3d molecule 2 2
MIRT635024 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT635384 NHLRC2 NHL repeat containing 2 2 2
MIRT635577 TTC9C tetratricopeptide repeat domain 9C 2 2
MIRT635793 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT635837 ZNF264 zinc finger protein 264 2 2
MIRT636043 ZSCAN29 zinc finger and SCAN domain containing 29 2 4
MIRT636070 ZNF280C zinc finger protein 280C 2 2
MIRT636697 ARSK arylsulfatase family member K 2 2
MIRT637438 ZNF324B zinc finger protein 324B 2 2
MIRT637582 PLD6 phospholipase D family member 6 2 2
MIRT637672 PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D 2 2
MIRT637887 SLC19A3 solute carrier family 19 member 3 2 4
MIRT638353 RBMS2 RNA binding motif single stranded interacting protein 2 2 4
MIRT638597 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT638821 CRTAP cartilage associated protein 2 2
MIRT638871 CEP97 centrosomal protein 97 2 4
MIRT639660 PPEF2 protein phosphatase with EF-hand domain 2 2 4
MIRT640200 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT641592 TNS4 tensin 4 2 2
MIRT644993 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT645059 UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII 2 2
MIRT646948 UPK3BL uroplakin 3B like 1 2 2
MIRT647306 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT648300 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 4
MIRT649043 SLC1A2 solute carrier family 1 member 2 2 2
MIRT649884 SLFN12L schlafen family member 12 like 2 2
MIRT650196 DOCK7 dedicator of cytokinesis 7 2 2
MIRT654789 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT655667 NUP43 nucleoporin 43 2 2
MIRT655925 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT656433 MARCH6 membrane associated ring-CH-type finger 6 2 2
MIRT657713 GPC4 glypican 4 2 2
MIRT659302 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT659844 CAPZB capping actin protein of muscle Z-line beta subunit 2 2
MIRT660660 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT661308 CPM carboxypeptidase M 2 2
MIRT661473 CHMP1B charged multivesicular body protein 1B 2 2
MIRT661906 EBNA1BP2 EBNA1 binding protein 2 2 2
MIRT662064 ZNF284 zinc finger protein 284 2 2
MIRT662491 ANGPT4 angiopoietin 4 2 2
MIRT662657 LRRC47 leucine rich repeat containing 47 2 2
MIRT662804 MSRB2 methionine sulfoxide reductase B2 2 2
MIRT663164 FGFR1OP FGFR1 oncogene partner 2 2
MIRT663376 ZNF770 zinc finger protein 770 2 4
MIRT663418 ZNF607 zinc finger protein 607 2 2
MIRT663990 WDR75 WD repeat domain 75 2 2
MIRT664157 APOBEC3F apolipoprotein B mRNA editing enzyme catalytic subunit 3F 2 4
MIRT664489 POLR3K RNA polymerase III subunit K 2 2
MIRT665058 CCDC77 coiled-coil domain containing 77 2 2
MIRT665080 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT665420 WDR55 WD repeat domain 55 2 2
MIRT665716 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT665923 TBC1D19 TBC1 domain family member 19 2 4
MIRT666239 SLC38A7 solute carrier family 38 member 7 2 4
MIRT666840 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT667378 MOB1B MOB kinase activator 1B 2 2
MIRT667573 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667894 ING1 inhibitor of growth family member 1 2 2
MIRT667977 HECTD3 HECT domain E3 ubiquitin protein ligase 3 2 2
MIRT668197 GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2 2
MIRT668279 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT668386 FAT3 FAT atypical cadherin 3 2 2
MIRT668444 FAM208A family with sequence similarity 208 member A 2 2
MIRT668998 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT669180 CCNF cyclin F 2 2
MIRT669444 ATL3 atlastin GTPase 3 2 2
MIRT669661 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2 2
MIRT669890 KIAA0754 KIAA0754 2 4
MIRT669973 SSR3 signal sequence receptor subunit 3 2 2
MIRT670153 SLC29A4 solute carrier family 29 member 4 2 2
MIRT670240 TRIM13 tripartite motif containing 13 2 2
MIRT670274 CBY3 chibby family member 3 2 2
MIRT670358 ULBP3 UL16 binding protein 3 2 4
MIRT670627 BVES blood vessel epicardial substance 2 2
MIRT670731 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670770 TRIM66 tripartite motif containing 66 2 2
MIRT670913 DESI1 desumoylating isopeptidase 1 2 2
MIRT671216 CLSTN1 calsyntenin 1 2 2
MIRT671398 ERCC6L2 ERCC excision repair 6 like 2 2 2
MIRT671427 TOX4 TOX high mobility group box family member 4 2 2
MIRT671654 TRUB2 TruB pseudouridine synthase family member 2 2 4
MIRT671702 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT672136 PLEKHH1 pleckstrin homology, MyTH4 and FERM domain containing H1 2 2
MIRT672395 SLC10A6 solute carrier family 10 member 6 2 2
MIRT672508 GGCX gamma-glutamyl carboxylase 2 2
MIRT672572 RNF24 ring finger protein 24 2 2
MIRT672789 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT673019 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT673190 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT673372 ZNF124 zinc finger protein 124 2 2
MIRT673495 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT673852 CAPN7 calpain 7 2 2
MIRT673929 ZNF500 zinc finger protein 500 2 2
MIRT673986 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT674076 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674123 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT674297 THAP5 THAP domain containing 5 2 2
MIRT674370 POLR3D RNA polymerase III subunit D 2 2
MIRT674641 NKRF NFKB repressing factor 2 2
MIRT674665 PLCE1 phospholipase C epsilon 1 2 2
MIRT674725 ZNF451 zinc finger protein 451 2 4
MIRT674779 NPR1 natriuretic peptide receptor 1 2 2
MIRT674889 RASSF9 Ras association domain family member 9 2 2
MIRT675017 SNX1 sorting nexin 1 2 2
MIRT675341 KLHL26 kelch like family member 26 2 2
MIRT675416 CLEC7A C-type lectin domain containing 7A 2 2
MIRT675497 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT675615 EHD2 EH domain containing 2 2 2
MIRT675735 AHR aryl hydrocarbon receptor 2 2
MIRT675857 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT675990 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676213 TMEM91 transmembrane protein 91 2 2
MIRT676406 MRO maestro 2 2
MIRT677299 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT677387 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT677859 ABI2 abl interactor 2 2 2
MIRT677965 ITGB3 integrin subunit beta 3 2 2
MIRT678175 CRCP CGRP receptor component 2 2
MIRT678273 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT678665 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT679003 TTC39B tetratricopeptide repeat domain 39B 2 2
MIRT679053 RMDN1 regulator of microtubule dynamics 1 2 2
MIRT679461 RHOF ras homolog family member F, filopodia associated 2 2
MIRT679513 RAB36 RAB36, member RAS oncogene family 2 2
MIRT679914 ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2 2
MIRT680029 OSBPL2 oxysterol binding protein like 2 2 4
MIRT680245 NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 2 2
MIRT680279 AKIP1 A-kinase interacting protein 1 2 2
MIRT680499 PRIM2 DNA primase subunit 2 2 2
MIRT680586 ZNF573 zinc finger protein 573 2 2
MIRT680629 KIAA1456 KIAA1456 2 2
MIRT680819 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT680998 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT681122 INTS7 integrator complex subunit 7 2 2
MIRT681161 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT681221 DUSP19 dual specificity phosphatase 19 2 2
MIRT681304 IKZF3 IKAROS family zinc finger 3 2 2
MIRT681341 BRI3BP BRI3 binding protein 2 2
MIRT681608 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT681779 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681892 SLC11A2 solute carrier family 11 member 2 2 2
MIRT682084 ITGA3 integrin subunit alpha 3 2 4
MIRT682139 SMS spermine synthase 2 2
MIRT682217 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682367 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682535 EXOSC2 exosome component 2 2 2
MIRT682618 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT683643 ZNF695 zinc finger protein 695 2 2
MIRT684008 FOLR1 folate receptor 1 2 2
MIRT684442 MFSD4 major facilitator superfamily domain containing 4A 2 2
MIRT684855 ZNF749 zinc finger protein 749 2 2
MIRT684956 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT685044 GEMIN4 gem nuclear organelle associated protein 4 2 2
MIRT685095 DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2 2
MIRT685382 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT685456 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT685810 SLC27A1 solute carrier family 27 member 1 2 2
MIRT685913 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686665 TMEM120B transmembrane protein 120B 2 2
MIRT686955 SFT2D2 SFT2 domain containing 2 2 2
MIRT687118 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT687739 KIAA1328 KIAA1328 2 2
MIRT688063 GLUL glutamate-ammonia ligase 2 2
MIRT688191 FNIP1 folliculin interacting protein 1 2 2
MIRT688769 CDH7 cadherin 7 2 2
MIRT688979 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT689572 NUDT7 nudix hydrolase 7 2 2
MIRT689683 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT689930 MANSC1 MANSC domain containing 1 2 2
MIRT690089 PNMA2 paraneoplastic Ma antigen 2 2 2
MIRT690190 C5orf45 MRN complex interacting protein 2 2
MIRT690246 CAMLG calcium modulating ligand 2 2
MIRT690411 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT690840 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT690889 FUT2 fucosyltransferase 2 2 2
MIRT691107 ADIPOQ adiponectin, C1Q and collagen domain containing 2 2
MIRT691229 DFNB59 pejvakin 2 2
MIRT691300 ZNF681 zinc finger protein 681 2 2
MIRT691366 GP5 glycoprotein V platelet 2 2
MIRT691797 WARS tryptophanyl-tRNA synthetase 2 2
MIRT692142 CEP104 centrosomal protein 104 2 2
MIRT692572 NCMAP non-compact myelin associated protein 2 2
MIRT692649 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT692744 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 2 2
MIRT693092 SCNM1 sodium channel modifier 1 2 2
MIRT693296 SYTL3 synaptotagmin like 3 2 2
MIRT693392 ZNF460 zinc finger protein 460 2 2
MIRT693530 ZNF708 zinc finger protein 708 2 2
MIRT693562 PIGR polymeric immunoglobulin receptor 2 2
MIRT694492 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT694722 LLGL1 LLGL1, scribble cell polarity complex component 2 2
MIRT694866 ZNF417 zinc finger protein 417 2 2
MIRT695070 ZNF17 zinc finger protein 17 2 2
MIRT695451 COX18 COX18, cytochrome c oxidase assembly factor 2 2
MIRT695724 ZNF117 zinc finger protein 117 2 2
MIRT695898 MED16 mediator complex subunit 16 2 2
MIRT696244 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT696259 TACO1 translational activator of cytochrome c oxidase I 2 2
MIRT696512 C3 complement C3 2 2
MIRT696560 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696643 AGXT2 alanine--glyoxylate aminotransferase 2 2 2
MIRT696791 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT696819 PLLP plasmolipin 2 2
MIRT697088 GPKOW G-patch domain and KOW motifs 2 2
MIRT697153 INMT indolethylamine N-methyltransferase 2 2
MIRT697202 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT697322 ZNF641 zinc finger protein 641 2 2
MIRT697578 YME1L1 YME1 like 1 ATPase 2 2
MIRT697619 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT698619 TES testin LIM domain protein 2 2
MIRT698804 STK38 serine/threonine kinase 38 2 2
MIRT698949 SPAST spastin 2 2
MIRT699083 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT699430 SLC1A5 solute carrier family 1 member 5 2 2
MIRT699550 SIT1 signaling threshold regulating transmembrane adaptor 1 2 2
MIRT700324 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT700360 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT700462 PURB purine rich element binding protein B 2 2
MIRT701677 MYADM myeloid associated differentiation marker 2 2
MIRT701757 MSL2 MSL complex subunit 2 2 2
MIRT701977 MIER3 MIER family member 3 2 2
MIRT703178 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT703203 GOLGA3 golgin A3 2 2
MIRT703359 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT703425 FYTTD1 forty-two-three domain containing 1 2 2
MIRT703484 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT703590 FBXO45 F-box protein 45 2 2
MIRT703806 EVI5 ecotropic viral integration site 5 2 2
MIRT703915 EPG5 ectopic P-granules autophagy protein 5 homolog 2 2
MIRT704234 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704646 CLCC1 chloride channel CLIC like 1 2 2
MIRT705151 C11orf58 chromosome 11 open reading frame 58 2 2
MIRT705480 ASXL2 additional sex combs like 2, transcriptional regulator 2 2
MIRT705530 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT705661 ANKRD40 ankyrin repeat domain 40 2 2
MIRT706144 ZNF674 zinc finger protein 674 2 2
MIRT706473 SNX27 sorting nexin family member 27 2 2
MIRT708254 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT708838 SCAND3 zinc finger BED-type containing 9 1 1
MIRT710437 BTNL3 butyrophilin like 3 2 2
MIRT711325 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT716151 RBM48 RNA binding motif protein 48 2 2
MIRT717402 ZCCHC24 zinc finger CCHC-type containing 24 2 2
MIRT720866 ADCY5 adenylate cyclase 5 2 2
MIRT722226 ZNF503 zinc finger protein 503 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1273h-5p Paclitaxel 36314 NSC125973 approved sensitive High Ovarian Cancer cell line (SKOV3)
hsa-miR-1273h-5p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-1273h-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

Error report submission