pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol C12orf66   
Synonyms -
Description chromosome 12 open reading frame 66
Transcript NM_152440   
Expression
Putative miRNA Targets on C12orf66
3'UTR of C12orf66
(miRNA target sites are highlighted)
>C12orf66|NM_152440|3'UTR
   1 CAGGTGATTTGCGTGGAGGGGTTTCAAGACTAGAAACTGTTCTTAATTGCCCTAATGATCTACGGTGGTCTGTGAATAGA
  81 GTTTACATCCATTCATGCCTCTTTCAGAACTAAATTAAAGACAAATCCTCCCTGTGTTGCACACTTTATAAGCAATTAAG
 161 GCCAATTGAATTAAGTTTCCAAAGAGTAATCTAGGAAGTGGTCATGGGCTACCATGTGTCTCCATGGTACAGCAAAGTAG
 241 TTTCAGTATTTTCCCCTATTTTGCTATATTTCTTGTAGATTGAATATTTATTGGGCTTTTTTTTTTCCCATATGTTTTTC
 321 TGTTGTTCTAAACATTGTGTTCTACTGCAATTCCAAACAGCCTCTCTGTTTCCCTCCTTCTTGGAAGAGTAATAGGGATG
 401 AGATATTAAATGGCCTTTTTAGAATTAAGAACTATATGTTTTCTGTCTCATAAATTAGCAAATGAATATGGAGTTAGTAG
 481 ATTTATGATTCTGATCTACAAATTAACATTTTTGATGCCAAAATTAGGGTCTTGGTAAGAAATTTCTATCAGTTATTGAA
 561 ACTGAAAGTGAGTCAGATTGGTAGCATGACGTAAGGTTTTAACAGTTCAGAAGATCCTCATGGCAGCTTTAATAGCCATG
 641 GGTTCTTTTGGGGTAATGTACACACCTAACTGCATTTGTTTTGACTTCTTTAATGTTTGAATGTTTCACTCTGTTGTAAA
 721 GTCAGCATAAGCCATCATGTGGGCTTTCTTCATTCTTCAGCATATTATCCGCTTCGCTTTCTGTTTATCACTTTTCTGCT
 801 GAAATGTACATGTTTGGCTCTACTCCTTGGTTATTTTTAGGCTTAAAAGCATGCAGTCGGTTTTTCAGCCACTTTTAGAT
 881 ACTCATGCAACATAGCCTACTTTTATAAAATCAAAATGAAGGTCTTCATACGCTGTACTTGCTAAAAATCAACTGTGCGC
 961 TTGAAAGACCTCTTCATAGTTGAGTAATCACCTCAGTACTTAAGCACTTCTGAACTTGGGTTTCATGCCTGCCCCCCACA
1041 AATTATGTTTAGAAGCAGCACTGCATCTTAGCACATGCTGCCTTATTTCTTTCCTTCGGCAGGTGTTCATGGGAAGTAGG
1121 TGGATCAGTGAAGGCATAATGGGCTGTGGAGACCTTCACTTCTAGATTATTGATTCAAAATAAAAAGAAGCCACAAAGAG
1201 TAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaCAUCCGGAA------AUCUAGUGAa 5'
            | || ||||      |||||:|:| 
Target 5' gtGGAGACCTTCACTTCTAGATTATTg 3'
1146 - 1172 129.00 -9.90
2
miRNA  3' uaCAUCCGGAAAUCUAGUGAa 5'
            |||||    |:||||| | 
Target 5' aaGTAGG----TGGATCAGTg 3'
1114 - 1130 125.00 -11.30
3
miRNA  3' uacauccggaaaucUAGUGAa 5'
                        |||||| 
Target 5' ttcgctttctgtttATCACTt 3'
773 - 793 120.00 -7.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30151065 16 COSMIC
COSN30530076 54 COSMIC
COSN31540310 63 COSMIC
COSN30493782 85 COSMIC
COSN30178445 105 COSMIC
COSN29848288 142 COSMIC
COSN7377573 294 COSMIC
COSN29724288 296 COSMIC
COSN24142984 505 COSMIC
COSN9567627 617 COSMIC
COSN27221068 632 COSMIC
COSN31960809 796 COSMIC
COSN24527797 841 COSMIC
COSN27049882 851 COSMIC
COSN30053888 1098 COSMIC
COSN30038540 1187 COSMIC
COSN18868803 1749 COSMIC
COSN22907554 2604 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1281025431 3 dbSNP
rs1228626655 11 dbSNP
rs775455348 12 dbSNP
rs767456687 13 dbSNP
rs369066527 19 dbSNP
rs984128275 20 dbSNP
rs79069626 21 dbSNP
rs372517636 22 dbSNP
rs766529334 24 dbSNP
rs1399411663 25 dbSNP
rs770286617 27 dbSNP
rs1178067307 29 dbSNP
rs1439933152 34 dbSNP
rs1252051604 36 dbSNP
rs1191355783 40 dbSNP
rs1469449690 42 dbSNP
rs991491968 57 dbSNP
rs1224096491 58 dbSNP
rs544852380 62 dbSNP
rs1035917500 63 dbSNP
rs1262508145 64 dbSNP
rs1176865438 67 dbSNP
rs1012967967 80 dbSNP
rs999034228 81 dbSNP
rs1177096366 84 dbSNP
rs1481611044 85 dbSNP
rs1200836151 97 dbSNP
rs967501998 105 dbSNP
rs575552102 114 dbSNP
rs1429198196 123 dbSNP
rs1483675683 130 dbSNP
rs184957969 132 dbSNP
rs1254337826 133 dbSNP
rs893317580 134 dbSNP
rs1021799615 153 dbSNP
rs1011106947 155 dbSNP
rs1452630135 158 dbSNP
rs368254953 163 dbSNP
rs893544756 166 dbSNP
rs1049885244 178 dbSNP
rs903413091 193 dbSNP
rs535494242 195 dbSNP
rs140042138 200 dbSNP
rs1282625910 203 dbSNP
rs1256274525 204 dbSNP
rs776699447 219 dbSNP
rs1234738359 223 dbSNP
rs1040906556 224 dbSNP
rs553480545 227 dbSNP
rs768563680 229 dbSNP
rs760796392 230 dbSNP
rs539554559 231 dbSNP
rs1216226012 232 dbSNP
rs1284110976 239 dbSNP
rs569665192 245 dbSNP
rs571380896 247 dbSNP
rs1223677076 251 dbSNP
rs181207062 263 dbSNP
rs1477330808 266 dbSNP
rs991913446 274 dbSNP
rs1291209598 276 dbSNP
rs1408135505 278 dbSNP
rs1414003883 283 dbSNP
rs1417965775 286 dbSNP
rs909083621 290 dbSNP
rs538110578 291 dbSNP
rs371620769 294 dbSNP
rs1424839559 297 dbSNP
rs1303685336 298 dbSNP
rs369774460 300 dbSNP
rs1467802756 306 dbSNP
rs376482275 307 dbSNP
rs558733694 307 dbSNP
rs919182863 307 dbSNP
rs375523672 308 dbSNP
rs1298659349 310 dbSNP
rs928876885 313 dbSNP
rs977708558 322 dbSNP
rs1022933162 325 dbSNP
rs775642591 328 dbSNP
rs1246904797 344 dbSNP
rs1289640734 346 dbSNP
rs1021832084 348 dbSNP
rs1473202107 350 dbSNP
rs1414908008 354 dbSNP
rs1186225997 356 dbSNP
rs201682294 357 dbSNP
rs1207287271 363 dbSNP
rs1475106573 364 dbSNP
rs1257337078 368 dbSNP
rs991608410 368 dbSNP
rs1176255211 374 dbSNP
rs1201763416 383 dbSNP
rs1484699051 389 dbSNP
rs59253153 391 dbSNP
rs114194680 396 dbSNP
rs1331121005 403 dbSNP
rs1028042540 405 dbSNP
rs1411418058 407 dbSNP
rs1171135460 412 dbSNP
rs996924104 413 dbSNP
rs1444412418 414 dbSNP
rs1329404339 417 dbSNP
rs1385036563 419 dbSNP
rs1453712716 420 dbSNP
rs115391565 434 dbSNP
rs1354763050 436 dbSNP
rs1019234890 447 dbSNP
rs1216673162 448 dbSNP
rs1274081611 454 dbSNP
rs1317846296 462 dbSNP
rs1197257158 465 dbSNP
rs1244466331 471 dbSNP
rs1314640029 473 dbSNP
rs79466051 475 dbSNP
rs79254473 481 dbSNP
rs998408666 485 dbSNP
rs1476305920 493 dbSNP
rs151219869 496 dbSNP
rs1422574520 498 dbSNP
rs1457880148 500 dbSNP
rs1038667598 501 dbSNP
rs768076630 504 dbSNP
rs1163351601 510 dbSNP
rs116677548 512 dbSNP
rs1333821024 515 dbSNP
rs1338939783 517 dbSNP
rs1433076153 522 dbSNP
rs1461395385 529 dbSNP
rs887515105 531 dbSNP
rs1048771177 532 dbSNP
rs1369351490 534 dbSNP
rs1323707849 536 dbSNP
rs371208109 538 dbSNP
rs1190059922 541 dbSNP
rs575518388 546 dbSNP
rs919058383 548 dbSNP
rs981774838 556 dbSNP
rs1464231139 559 dbSNP
rs894561526 560 dbSNP
rs778328652 562 dbSNP
rs1201586692 563 dbSNP
rs949991655 574 dbSNP
rs867235415 589 dbSNP
rs368954919 590 dbSNP
rs1477621512 591 dbSNP
rs541820361 596 dbSNP
rs928654487 603 dbSNP
rs1270763685 609 dbSNP
rs573146374 611 dbSNP
rs1212938822 615 dbSNP
rs1356982985 622 dbSNP
rs1402683361 624 dbSNP
rs1299004234 631 dbSNP
rs1266983463 633 dbSNP
rs957468290 638 dbSNP
rs1346715337 640 dbSNP
rs576153400 642 dbSNP
rs1297192412 648 dbSNP
rs946304572 652 dbSNP
rs745895749 654 dbSNP
rs914807059 655 dbSNP
rs7969588 656 dbSNP
rs1029795763 666 dbSNP
rs185135732 673 dbSNP
rs1450997272 681 dbSNP
rs1196596647 690 dbSNP
rs1392171015 708 dbSNP
rs1376042962 714 dbSNP
rs568665777 733 dbSNP
rs998877500 734 dbSNP
rs900079392 735 dbSNP
rs1028492706 742 dbSNP
rs975228696 761 dbSNP
rs148652510 762 dbSNP
rs965089759 768 dbSNP
rs115027388 770 dbSNP
rs1372113442 771 dbSNP
rs1003814560 775 dbSNP
rs569170576 776 dbSNP
rs1337081197 783 dbSNP
rs1240220726 791 dbSNP
rs887040844 800 dbSNP
rs1007193660 807 dbSNP
rs1247664742 821 dbSNP
rs1026871032 823 dbSNP
rs1355347727 829 dbSNP
rs762067188 833 dbSNP
rs1192534780 837 dbSNP
rs1048800691 838 dbSNP
rs549250455 842 dbSNP
rs993229129 845 dbSNP
rs61931230 848 dbSNP
rs1237576406 852 dbSNP
rs1411993778 856 dbSNP
rs1165656470 858 dbSNP
rs1269433531 859 dbSNP
rs1369459874 861 dbSNP
rs894350205 868 dbSNP
rs1457713528 869 dbSNP
rs535757266 872 dbSNP
rs1056027054 875 dbSNP
rs1162034984 879 dbSNP
rs938777528 881 dbSNP
rs1448076697 883 dbSNP
rs754572653 885 dbSNP
rs1041759800 888 dbSNP
rs751391604 892 dbSNP
rs566426795 896 dbSNP
rs1252794283 902 dbSNP
rs546297395 905 dbSNP
rs990377357 914 dbSNP
rs1257531792 918 dbSNP
rs766099639 928 dbSNP
rs528155796 931 dbSNP
rs1423401209 932 dbSNP
rs925903270 933 dbSNP
rs1232706340 935 dbSNP
rs1466620917 952 dbSNP
rs1332159123 954 dbSNP
rs977917014 957 dbSNP
rs976205840 958 dbSNP
rs965121341 959 dbSNP
rs548302172 961 dbSNP
rs1470667369 963 dbSNP
rs982422245 970 dbSNP
rs1303127710 973 dbSNP
rs951042802 978 dbSNP
rs1378009119 986 dbSNP
rs7972885 991 dbSNP
rs1297501093 992 dbSNP
rs1309034159 992 dbSNP
rs1431184400 1005 dbSNP
rs995473016 1008 dbSNP
rs1392941944 1020 dbSNP
rs1217993937 1029 dbSNP
rs958859468 1037 dbSNP
rs1316201633 1038 dbSNP
rs1212349346 1039 dbSNP
rs1256593054 1045 dbSNP
rs73323086 1046 dbSNP
rs144050544 1056 dbSNP
rs1264355032 1063 dbSNP
rs1378891347 1071 dbSNP
rs1193658983 1075 dbSNP
rs74097948 1077 dbSNP
rs1481672520 1081 dbSNP
rs1176163592 1083 dbSNP
rs1358033464 1086 dbSNP
rs1437176617 1093 dbSNP
rs1252184341 1094 dbSNP
rs1207111982 1097 dbSNP
rs1464252763 1099 dbSNP
rs528798805 1100 dbSNP
rs1041789152 1109 dbSNP
rs559671669 1118 dbSNP
rs1278521367 1123 dbSNP
rs1010243162 1127 dbSNP
rs1399164264 1128 dbSNP
rs139584118 1129 dbSNP
rs1347321477 1130 dbSNP
rs577258695 1134 dbSNP
rs1219693611 1143 dbSNP
rs1302096801 1150 dbSNP
rs557536820 1154 dbSNP
rs1231386408 1158 dbSNP
rs80310420 1159 dbSNP
rs7972319 1160 dbSNP
rs775617471 1162 dbSNP
rs897558160 1163 dbSNP
rs1046006972 1167 dbSNP
rs1490993223 1176 dbSNP
rs1289361248 1187 dbSNP
rs1392078343 1187 dbSNP
rs866011654 1189 dbSNP
rs7972639 1194 dbSNP
rs894287182 1195 dbSNP
rs944843957 1196 dbSNP
rs912315989 1197 dbSNP
rs1380539032 1198 dbSNP
rs1418639684 1198 dbSNP
rs1373206120 1200 dbSNP
rs1367150924 1205 dbSNP
rs1437166939 1211 dbSNP
rs1472862971 1215 dbSNP
rs1292838109 1219 dbSNP
rs982536791 1234 dbSNP
rs1367076845 1239 dbSNP
rs951200521 1241 dbSNP
rs1311480989 1243 dbSNP
rs142688131 1255 dbSNP
rs1414702159 1256 dbSNP
rs759764299 1264 dbSNP
rs774869668 1265 dbSNP
rs1323859934 1274 dbSNP
rs1246638066 1277 dbSNP
rs1469556983 1277 dbSNP
rs1412695408 1284 dbSNP
rs935868453 1287 dbSNP
rs1179973394 1291 dbSNP
rs925975412 1300 dbSNP
rs1438717167 1305 dbSNP
rs1156432411 1307 dbSNP
rs2279740 1313 dbSNP
rs1405733075 1323 dbSNP
rs1164068504 1324 dbSNP
rs946146525 1327 dbSNP
rs1256584262 1334 dbSNP
rs1209622727 1351 dbSNP
rs922724703 1359 dbSNP
rs192578611 1369 dbSNP
rs1377681582 1374 dbSNP
rs76060762 1389 dbSNP
rs1307314528 1393 dbSNP
rs1381884157 1394 dbSNP
rs1203539609 1396 dbSNP
rs1289522145 1398 dbSNP
rs789749 1401 dbSNP
rs1258195176 1402 dbSNP
rs866789331 1403 dbSNP
rs1456906780 1415 dbSNP
rs1176465093 1416 dbSNP
rs1238831258 1418 dbSNP
rs73132117 1421 dbSNP
rs952964575 1422 dbSNP
rs1411309399 1427 dbSNP
rs1230806499 1428 dbSNP
rs138410958 1431 dbSNP
rs1283982639 1433 dbSNP
rs1448213493 1437 dbSNP
rs187682980 1442 dbSNP
rs762549217 1462 dbSNP
rs796588110 1470 dbSNP
rs780709500 1471 dbSNP
rs150269969 1472 dbSNP
rs528760844 1473 dbSNP
rs1054482317 1497 dbSNP
rs996555275 1498 dbSNP
rs1280043469 1503 dbSNP
rs754634076 1506 dbSNP
rs1040566247 1507 dbSNP
rs944958733 1515 dbSNP
rs1459832259 1517 dbSNP
rs908086475 1519 dbSNP
rs746608923 1525 dbSNP
rs1422817243 1529 dbSNP
rs1476769529 1533 dbSNP
rs1166256997 1538 dbSNP
rs1427292669 1549 dbSNP
rs183839210 1556 dbSNP
rs191593992 1557 dbSNP
rs186790742 1561 dbSNP
rs750203681 1568 dbSNP
rs142010139 1569 dbSNP
rs1276130618 1570 dbSNP
rs1345084659 1577 dbSNP
rs1218322249 1582 dbSNP
rs1276065522 1583 dbSNP
rs1489184086 1595 dbSNP
rs1464467169 1596 dbSNP
rs946088122 1601 dbSNP
rs901129851 1626 dbSNP
rs1041143114 1629 dbSNP
rs1379484119 1630 dbSNP
rs1478393422 1633 dbSNP
rs543729310 1637 dbSNP
rs1172271796 1641 dbSNP
rs1211059621 1641 dbSNP
rs12817152 1642 dbSNP
rs12817151 1644 dbSNP
rs12817145 1651 dbSNP
rs973778859 1652 dbSNP
rs1333337448 1654 dbSNP
rs148129276 1657 dbSNP
rs543901101 1658 dbSNP
rs12817137 1660 dbSNP
rs1331250512 1663 dbSNP
rs927196199 1665 dbSNP
rs981395857 1675 dbSNP
rs575005905 1677 dbSNP
rs971296315 1686 dbSNP
rs143772480 1687 dbSNP
rs1285099262 1691 dbSNP
rs1268093167 1696 dbSNP
rs1433950486 1698 dbSNP
rs1211632660 1704 dbSNP
rs973368666 1707 dbSNP
rs1450903350 1709 dbSNP
rs961737086 1710 dbSNP
rs1024355531 1712 dbSNP
rs1179471471 1712 dbSNP
rs12817103 1712 dbSNP
rs1441801321 1712 dbSNP
rs568712559 1712 dbSNP
rs12818531 1714 dbSNP
rs1365230898 1715 dbSNP
rs992611026 1720 dbSNP
rs12817095 1721 dbSNP
rs958441483 1722 dbSNP
rs1034207321 1724 dbSNP
rs556060634 1724 dbSNP
rs1246733412 1725 dbSNP
rs1265741014 1731 dbSNP
rs1165203462 1732 dbSNP
rs541690891 1734 dbSNP
rs1417164345 1742 dbSNP
rs1459123177 1745 dbSNP
rs902508703 1749 dbSNP
rs1237789992 1753 dbSNP
rs1449105206 1754 dbSNP
rs1190059883 1755 dbSNP
rs1248645625 1756 dbSNP
rs1369375408 1764 dbSNP
rs1190671498 1766 dbSNP
rs1467514823 1767 dbSNP
rs1246684702 1769 dbSNP
rs1222737760 1775 dbSNP
rs1434371426 1776 dbSNP
rs1271357899 1778 dbSNP
rs1465688407 1780 dbSNP
rs1330013453 1782 dbSNP
rs1227139477 1783 dbSNP
rs1397369446 1787 dbSNP
rs1313200265 1791 dbSNP
rs1339620368 1793 dbSNP
rs1342438535 1795 dbSNP
rs1299174024 1796 dbSNP
rs1199352872 1798 dbSNP
rs1257435955 1798 dbSNP
rs1280001052 1798 dbSNP
rs1320175670 1798 dbSNP
rs1376373619 1798 dbSNP
rs1479791302 1798 dbSNP
rs371097999 1798 dbSNP
rs1231517871 1799 dbSNP
rs1169369358 1800 dbSNP
rs1366779452 1802 dbSNP
rs1303044019 1807 dbSNP
rs1467296577 1807 dbSNP
rs1401303819 1827 dbSNP
rs1412696333 1829 dbSNP
rs989030311 1830 dbSNP
rs904334089 1842 dbSNP
rs957493535 1847 dbSNP
rs1033481227 1848 dbSNP
rs901209389 1849 dbSNP
rs111488332 1856 dbSNP
rs183122654 1861 dbSNP
rs574545546 1866 dbSNP
rs1209196577 1869 dbSNP
rs1265736584 1879 dbSNP
rs560791432 1883 dbSNP
rs942813667 1885 dbSNP
rs539724840 1886 dbSNP
rs1259115403 1891 dbSNP
rs1009132488 1893 dbSNP
rs886677487 1897 dbSNP
rs146811487 1899 dbSNP
rs1376719103 1900 dbSNP
rs1432415573 1902 dbSNP
rs1424591802 1903 dbSNP
rs1360883529 1905 dbSNP
rs930779477 1910 dbSNP
rs898253719 1913 dbSNP
rs1287038763 1921 dbSNP
rs1192236656 1923 dbSNP
rs1038486369 1924 dbSNP
rs757170269 1937 dbSNP
rs1479299805 1940 dbSNP
rs191364567 1944 dbSNP
rs981087655 1947 dbSNP
rs1288654559 1950 dbSNP
rs973015842 1950 dbSNP
rs1483172388 1952 dbSNP
rs1215775742 1955 dbSNP
rs1259482616 1958 dbSNP
rs1276397801 1959 dbSNP
rs949971343 1960 dbSNP
rs949660622 1961 dbSNP
rs145078037 1966 dbSNP
rs988674399 1967 dbSNP
rs1311050923 1969 dbSNP
rs1452215501 1973 dbSNP
rs1301378005 1975 dbSNP
rs1180086669 1983 dbSNP
rs1220810680 1985 dbSNP
rs1380730406 1986 dbSNP
rs1418867133 1996 dbSNP
rs541881844 1997 dbSNP
rs114162526 2001 dbSNP
rs796197051 2002 dbSNP
rs958472325 2004 dbSNP
rs548359488 2013 dbSNP
rs1439044795 2015 dbSNP
rs1311721895 2016 dbSNP
rs1034113806 2020 dbSNP
rs1223581675 2024 dbSNP
rs1032844680 2029 dbSNP
rs1371362491 2030 dbSNP
rs1324048762 2031 dbSNP
rs1310047787 2032 dbSNP
rs534953049 2034 dbSNP
rs968588718 2041 dbSNP
rs566265792 2047 dbSNP
rs1200218563 2048 dbSNP
rs1238415903 2053 dbSNP
rs964753247 2056 dbSNP
rs34664799 2071 dbSNP
rs1469259752 2080 dbSNP
rs1175291632 2084 dbSNP
rs1415646148 2096 dbSNP
rs1424369946 2100 dbSNP
rs1018924718 2102 dbSNP
rs1008832767 2107 dbSNP
rs1163964196 2108 dbSNP
rs12303448 2110 dbSNP
rs1026950119 2111 dbSNP
rs1459937464 2114 dbSNP
rs1176894047 2148 dbSNP
rs995020792 2151 dbSNP
rs965657528 2154 dbSNP
rs1278174197 2161 dbSNP
rs7968367 2161 dbSNP
rs532855325 2173 dbSNP
rs937100096 2187 dbSNP
rs905590044 2189 dbSNP
rs1229440431 2190 dbSNP
rs1293195566 2191 dbSNP
rs1333248839 2192 dbSNP
rs1219953689 2193 dbSNP
rs1258090998 2201 dbSNP
rs1436897782 2208 dbSNP
rs1201970102 2214 dbSNP
rs1473099713 2216 dbSNP
rs752722621 2217 dbSNP
rs1254442664 2232 dbSNP
rs1415587066 2238 dbSNP
rs563643573 2239 dbSNP
rs1045443006 2242 dbSNP
rs1006861467 2244 dbSNP
rs1179692416 2246 dbSNP
rs889762858 2249 dbSNP
rs949671114 2257 dbSNP
rs913159003 2259 dbSNP
rs1327069694 2270 dbSNP
rs1256065778 2279 dbSNP
rs1211686250 2282 dbSNP
rs1449224975 2286 dbSNP
rs1312595191 2288 dbSNP
rs989175481 2298 dbSNP
rs935926928 2301 dbSNP
rs183557571 2306 dbSNP
rs769234728 2317 dbSNP
rs918150231 2342 dbSNP
rs974584568 2347 dbSNP
rs190926708 2357 dbSNP
rs7954909 2358 dbSNP
rs1255074809 2372 dbSNP
rs776426978 2373 dbSNP
rs1194253659 2374 dbSNP
rs950682713 2377 dbSNP
rs968870908 2378 dbSNP
rs145196930 2385 dbSNP
rs1427548382 2402 dbSNP
rs913090725 2404 dbSNP
rs1173444176 2421 dbSNP
rs1373997388 2422 dbSNP
rs149735292 2423 dbSNP
rs139636303 2424 dbSNP
rs1387053127 2425 dbSNP
rs1276049673 2429 dbSNP
rs1367891177 2433 dbSNP
rs545747461 2440 dbSNP
rs963648058 2450 dbSNP
rs1159011684 2451 dbSNP
rs552918931 2453 dbSNP
rs1233056730 2456 dbSNP
rs1277968887 2469 dbSNP
rs1019510397 2472 dbSNP
rs576749508 2477 dbSNP
rs1283465687 2479 dbSNP
rs539462243 2482 dbSNP
rs1026932861 2487 dbSNP
rs1248490415 2488 dbSNP
rs995641614 2489 dbSNP
rs897212555 2492 dbSNP
rs1002350121 2494 dbSNP
rs905624166 2502 dbSNP
rs1228790440 2529 dbSNP
rs1256476790 2531 dbSNP
rs1183061520 2537 dbSNP
rs11280816 2538 dbSNP
rs553975816 2538 dbSNP
rs1045473627 2543 dbSNP
rs1209218949 2546 dbSNP
rs536683666 2553 dbSNP
rs1331145465 2561 dbSNP
rs1378918329 2566 dbSNP
rs1013930940 2574 dbSNP
rs896629321 2576 dbSNP
rs1278689934 2579 dbSNP
rs1348498666 2580 dbSNP
rs574187027 2581 dbSNP
rs1055393299 2584 dbSNP
rs554320590 2591 dbSNP
rs891490441 2593 dbSNP
rs534724764 2596 dbSNP
rs150674680 2598 dbSNP
rs61365921 2598 dbSNP
rs1251379577 2603 dbSNP
rs947187631 2603 dbSNP
rs935940908 2612 dbSNP
rs1183012557 2621 dbSNP
rs925869369 2625 dbSNP
rs1363541668 2628 dbSNP
rs1469088136 2631 dbSNP
rs1165481951 2637 dbSNP
rs10629256 2642 dbSNP
rs561419965 2642 dbSNP
rs1398026563 2656 dbSNP
rs1039295438 2659 dbSNP
rs1323224796 2674 dbSNP
rs1402055481 2675 dbSNP
rs943174539 2678 dbSNP
rs1327983265 2688 dbSNP
rs566106006 2690 dbSNP
rs987557154 2699 dbSNP
rs1319976656 2702 dbSNP
rs1436461762 2715 dbSNP
rs1391539703 2716 dbSNP
rs1271295991 2736 dbSNP
rs950793373 2741 dbSNP
rs770231468 2754 dbSNP
rs1196571730 2759 dbSNP
rs60438943 2760 dbSNP
rs1190297882 2762 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uacauccggaaAUCUAGUGAa 5'
                     |:||||||| 
Target 5' ---------cgUGGAUCACUu 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000544871.1 | 3UTR | CGUGGAUCACUUGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.946 0.11 0.500 0.33 3 Click to see details
HNSC 0.24 0.3 0.143 0.38 7 Click to see details
UCEC -0.42 0.36 -0.500 0.33 3 Click to see details
BLCA 0.236 0.42 0.500 0.33 3 Click to see details
BLCA 0.236 0.42 0.500 0.33 3 Click to see details
BLCA 0.236 0.42 0.500 0.33 3 Click to see details
BLCA 0.236 0.42 0.500 0.33 3 Click to see details
BLCA 0.236 0.42 0.500 0.33 3 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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