miRTarBase - #MIRT629509


—
pre-miRNA Information
pre-miRNA hsa-mir-1245a   
Genomic Coordinates chr2: 188978092 - 188978161
Description Homo sapiens miR-1245a stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1245a
Sequence 45| AAGUGAUCUAAAGGCCUACAU |65
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31562560 15 COSMIC
COSN26581044 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs906938680 2 dbSNP
rs1159117523 3 dbSNP
rs780486044 6 dbSNP
rs771479866 17 dbSNP
rs1002976932 18 dbSNP
rs1428029219 19 dbSNP
Putative Targets

Gene Information
Gene Symbol AS3MT   
Synonyms CYT19
Description arsenite methyltransferase
Transcript NM_020682   
Expression
Putative miRNA Targets on AS3MT
3'UTR of AS3MT
(miRNA target sites are highlighted)		 
>AS3MT|NM_020682|3'UTR
   1 ATCTATAGCCAACCAGGGGACCACAGTAGTGGGCAAGAGTGATCTGCATGTTTTTTAACCTGCTTTTCCCCATAGCACAG
  81 ACCATAAGAAACAACAAATGGGGCCGGGCACAGTGGCTCATGCCTATAATCCCAGCACTTTGGGAGGCCGAGGCAGGCAG
 161 ATCACCTGAGGTCAGGAGTTTGATACCAGCCTGGCCAACATGGTGAAATCCTGTCTCTACCAAAAATACAAAAAAAATTA
 241 GCTGGGCATGGTGGTGCACACCTATAGTCTCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAAGTAG
 321 AGGCTGCAGTGAGTAAGCATCACGCCACTGTACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAAAAGCAAAAAAAA
 401 AAAAAAAAAAAGAAAGAAAGAAAAAGAAAACAACAAATGGCAGAGAGCCACCATATTCCAAATCACTGAAAAAAATAAAT
 481 GAATTATTTTTATTTATTTATTTATTTTTTTGAGATGGAGTCTCGGTCTGTTGCCCAGGCTGAAGTGCAGTGGCCCCATC
 561 TCAACTCACTGCAAGCTCCACCTCCTGGGTTCACGCCATTCTCCTGCCTCAGACTCCCAAGTAGCTGGGACTACAGGCAC
 641 CTACCACCATGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTTGATCTC
 721 CTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAAGCATGAGCCACTGCGCCCGGCCATAAATGA
 801 ATTATTTTTAAGAGGCATTGATTAAAGATTCACAGCAAATCACTAGTTAAGCAGATTTTTTTTCTATTTCCTACTTCAAA
 881 GTTCTGGTGCCACATAGTGGTCAGAAATGGAACAGAGAAGCTGTCTTAAGCCTTGTTCAAGAAGCAGGAAAGGCATCAGA
 961 AGAAGTAACAGTTGGCAGAGGGTCTCAGGAAAAACATCTTCCTTCTGATCTTTTGCATAGCACCTTTTGGAATTTTCATC
1041 ATGTTTGCTTATTAAACAAAGCTCCTACTGCCATCATACTAATCATGCAAAAAGATTGCCAAATCATGTTTGGTAGGAGG
1121 ACTTTTGAGGTAGCTTTTGAACAAATGTTTTTTTCTTTTTTCTTTTTTTTTGCAATAAAGAAAACAAATTAATCATAAAA
1201 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uacaUCCGGAAAUCUAGUGaa 5'
              ||||    |||||||  
Target 5' gccgAGGCAGGCAGATCACct 3'
 147 - 167 133.00 -13.90
2 
miRNA  3' uacaUCCGGAAAUCUAGUGaa 5'
              | |:  | :|||:||  
Target 5' cccaAAGTGCTGGGATTACaa 3'
 750 - 770 109.00 -8.00
3 
miRNA  3' uacauccGGAAAUCUAGUGAa 5'
                 ||||  |||| :| 
Target 5' acatcttCCTTCTGATCTTTt 3'
 994 - 1014 106.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26968226 3 COSMIC
COSN30473227 49 COSMIC
COSN30493179 52 COSMIC
COSN31552207 57 COSMIC
COSN30139856 120 COSMIC
COSN5276506 215 COSMIC
COSN16273139 721 COSMIC
COSN26262958 746 COSMIC
COSN22250134 821 COSMIC
COSN5859839 864 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769037979 2 dbSNP
rs761947124 4 dbSNP
rs1041278623 6 dbSNP
rs904393626 7 dbSNP
rs752893520 16 dbSNP
rs17879039 18 dbSNP
rs1253519929 20 dbSNP
rs750888847 23 dbSNP
rs1236905552 24 dbSNP
rs761145191 27 dbSNP
rs766761833 31 dbSNP
rs754197188 34 dbSNP
rs1162066027 41 dbSNP
rs1224773044 43 dbSNP
rs542009468 48 dbSNP
rs777354391 49 dbSNP
rs888846940 50 dbSNP
rs1330317956 61 dbSNP
rs1006069078 63 dbSNP
rs1305820944 72 dbSNP
rs1391649981 73 dbSNP
rs1398356378 82 dbSNP
rs1300923398 93 dbSNP
rs1014162764 98 dbSNP
rs1025009779 100 dbSNP
rs1178530405 106 dbSNP
rs1037507431 107 dbSNP
rs897749416 108 dbSNP
rs993455331 115 dbSNP
rs1351298555 120 dbSNP
rs1362177975 121 dbSNP
rs1181356360 135 dbSNP
rs1419964824 137 dbSNP
rs1252950057 141 dbSNP
rs1002739256 150 dbSNP
rs1035606230 151 dbSNP
rs960344692 153 dbSNP
rs1215305503 156 dbSNP
rs1283295834 160 dbSNP
rs1012901295 162 dbSNP
rs1264243513 163 dbSNP
rs1206173802 172 dbSNP
rs1023490502 173 dbSNP
rs1347877802 175 dbSNP
rs1278507675 188 dbSNP
rs1239297743 195 dbSNP
rs1337101118 200 dbSNP
rs1490682142 202 dbSNP
rs963761320 204 dbSNP
rs968804051 213 dbSNP
rs1383321915 216 dbSNP
rs1199711025 218 dbSNP
rs751474682 221 dbSNP
rs1455640191 222 dbSNP
rs185693154 223 dbSNP
rs1026418373 230 dbSNP
rs1158013372 230 dbSNP
rs924820543 231 dbSNP
rs10883798 232 dbSNP
rs1364929563 237 dbSNP
rs1365718746 238 dbSNP
rs987669004 249 dbSNP
rs1419596107 251 dbSNP
rs1157343330 252 dbSNP
rs977000457 257 dbSNP
rs797018563 264 dbSNP
rs17881031 265 dbSNP
rs564095616 267 dbSNP
rs1050063566 268 dbSNP
rs910299238 274 dbSNP
rs934376199 277 dbSNP
rs941723393 280 dbSNP
rs748058096 281 dbSNP
rs1316970124 294 dbSNP
rs917076039 296 dbSNP
rs1325720958 299 dbSNP
rs1318931207 301 dbSNP
rs1382802968 305 dbSNP
rs897698585 306 dbSNP
rs1409355966 309 dbSNP
rs1161866552 313 dbSNP
rs1424332713 314 dbSNP
rs949982791 319 dbSNP
rs1165798197 324 dbSNP
rs1384925217 331 dbSNP
rs1044334169 337 dbSNP
rs1242002413 342 dbSNP
rs531237403 344 dbSNP
rs189373200 345 dbSNP
rs1266234621 346 dbSNP
rs1239361825 351 dbSNP
rs1359636984 360 dbSNP
rs1306912611 369 dbSNP
rs11191456 375 dbSNP
rs1338535660 377 dbSNP
rs1222576513 378 dbSNP
rs1002219978 380 dbSNP
rs1264551737 383 dbSNP
rs1487287767 386 dbSNP
rs1197969730 387 dbSNP
rs1251729636 391 dbSNP
rs1334687012 392 dbSNP
rs1366353743 392 dbSNP
rs1197988263 393 dbSNP
rs1202069576 393 dbSNP
rs1270536597 393 dbSNP
rs1341181950 393 dbSNP
rs1427833820 393 dbSNP
rs1476707627 393 dbSNP
rs1490380850 393 dbSNP
rs370301616 393 dbSNP
rs386372295 393 dbSNP
rs1439420520 394 dbSNP
rs1177330167 395 dbSNP
rs1387560302 401 dbSNP
rs1445387543 404 dbSNP
rs1038079837 406 dbSNP
rs1348410283 407 dbSNP
rs1197467028 408 dbSNP
rs1259585118 409 dbSNP
rs1321259178 409 dbSNP
rs1346254266 409 dbSNP
rs1463746493 410 dbSNP
rs1491041372 411 dbSNP
rs10679836 412 dbSNP
rs1400773897 412 dbSNP
rs111383152 413 dbSNP
rs1329308547 417 dbSNP
rs202234330 421 dbSNP
rs1228444024 423 dbSNP
rs375956115 427 dbSNP
rs369772168 432 dbSNP
rs1480466850 435 dbSNP
rs1484547027 452 dbSNP
rs1057426595 453 dbSNP
rs1251472198 469 dbSNP
rs1175110219 473 dbSNP
rs1469360235 477 dbSNP
rs1233110143 481 dbSNP
rs41310292 486 dbSNP
rs1459836950 487 dbSNP
rs1197142924 489 dbSNP
rs755782532 493 dbSNP
rs1022932994 501 dbSNP
rs993972360 505 dbSNP
rs180954710 509 dbSNP
rs1411741246 511 dbSNP
rs534291133 519 dbSNP
rs1430320109 525 dbSNP
rs552424615 526 dbSNP
rs1381107975 527 dbSNP
rs1423175254 535 dbSNP
rs1464958527 538 dbSNP
rs1470625688 544 dbSNP
rs1329018097 549 dbSNP
rs1360373380 551 dbSNP
rs1031703091 555 dbSNP
rs1156239556 565 dbSNP
rs1408260834 570 dbSNP
rs1009140186 577 dbSNP
rs1448710427 580 dbSNP
rs1017815201 582 dbSNP
rs1442520067 584 dbSNP
rs1355127244 589 dbSNP
rs965296369 595 dbSNP
rs978463086 596 dbSNP
rs558466019 598 dbSNP
rs1376363650 602 dbSNP
rs956228709 604 dbSNP
rs976921037 611 dbSNP
rs1316440228 614 dbSNP
rs1285197547 619 dbSNP
rs1030338288 620 dbSNP
rs1242640912 622 dbSNP
rs954285603 633 dbSNP
rs986205008 634 dbSNP
rs1314858464 639 dbSNP
rs1316910598 639 dbSNP
rs1217242160 640 dbSNP
rs1381885216 649 dbSNP
rs577065711 651 dbSNP
rs988552631 653 dbSNP
rs910259065 656 dbSNP
rs1429331597 662 dbSNP
rs375571471 667 dbSNP
rs1429355403 668 dbSNP
rs1324650277 684 dbSNP
rs941671160 685 dbSNP
rs1422433254 687 dbSNP
rs569371381 688 dbSNP
rs1163912477 697 dbSNP
rs917127989 698 dbSNP
rs1236160403 701 dbSNP
rs973180706 702 dbSNP
rs1486926886 703 dbSNP
rs949867589 704 dbSNP
rs1185913745 705 dbSNP
rs1485568208 708 dbSNP
rs1262799306 715 dbSNP
rs1476945987 716 dbSNP
rs918991274 729 dbSNP
rs1291319218 730 dbSNP
rs1247118457 732 dbSNP
rs1219478241 734 dbSNP
rs929142161 736 dbSNP
rs531706040 740 dbSNP
rs1175278346 741 dbSNP
rs895730546 745 dbSNP
rs1357357688 746 dbSNP
rs1299435575 755 dbSNP
rs1454949071 757 dbSNP
rs948703634 774 dbSNP
rs1044695385 782 dbSNP
rs1459232905 785 dbSNP
rs1339491060 786 dbSNP
rs17884001 789 dbSNP
rs1140107 790 dbSNP
rs1000134191 791 dbSNP
rs1140108 798 dbSNP
rs1031732528 804 dbSNP
rs891850579 815 dbSNP
rs1037732764 816 dbSNP
rs1223564550 819 dbSNP
rs899147211 837 dbSNP
rs993629769 852 dbSNP
rs540811697 856 dbSNP
rs1280685534 867 dbSNP
rs1284738122 875 dbSNP
rs1047799054 877 dbSNP
rs890498703 878 dbSNP
rs556611661 882 dbSNP
rs1394055906 887 dbSNP
rs1218999633 895 dbSNP
rs1017698665 908 dbSNP
rs574742253 916 dbSNP
rs568318005 919 dbSNP
rs1217488363 920 dbSNP
rs559483876 926 dbSNP
rs1029790726 954 dbSNP
rs796946519 958 dbSNP
rs748879649 960 dbSNP
rs1468276867 964 dbSNP
rs535749222 966 dbSNP
rs1428730383 971 dbSNP
rs1201877733 977 dbSNP
rs1435189593 988 dbSNP
rs1269789626 990 dbSNP
rs139614098 999 dbSNP
rs1017187443 1016 dbSNP
rs1458512114 1024 dbSNP
rs1260529906 1025 dbSNP
rs1046778 1028 dbSNP
rs955896169 1033 dbSNP
rs988436645 1034 dbSNP
rs1234804826 1041 dbSNP
rs973041717 1046 dbSNP
rs1420778839 1048 dbSNP
rs1159142035 1049 dbSNP
rs1391706111 1052 dbSNP
rs919023735 1062 dbSNP
rs929006386 1064 dbSNP
rs917010519 1065 dbSNP
rs545863602 1066 dbSNP
rs1405423269 1071 dbSNP
rs917122192 1074 dbSNP
rs776303877 1076 dbSNP
rs1173174628 1077 dbSNP
rs1377822343 1082 dbSNP
rs563999499 1085 dbSNP
rs979952977 1087 dbSNP
rs1044343360 1108 dbSNP
rs1304650450 1119 dbSNP
rs927102473 1120 dbSNP
rs1240491866 1123 dbSNP
rs1350092293 1131 dbSNP
rs1461217309 1145 dbSNP
rs1257483163 1147 dbSNP
rs941318784 1148 dbSNP
rs1436266356 1149 dbSNP
rs974387724 1150 dbSNP
rs145412261 1152 dbSNP
rs773810340 1154 dbSNP
rs1375930704 1156 dbSNP
rs925846786 1159 dbSNP
rs1047685906 1163 dbSNP
rs929309693 1163 dbSNP
rs1383387594 1167 dbSNP
rs890554033 1170 dbSNP
rs1397838322 1173 dbSNP
rs541948236 1177 dbSNP
rs1288508766 1180 dbSNP
rs1351607859 1183 dbSNP
rs1224813332 1195 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uacaUCCGGAAAUCUAGugaa 5'
              |||:   |:||||    
Target 5' gucaAGGUGGGUGGAUC---- 3'
 		8 - 24
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000369880.3 | 3UTR | UUGGGAGGUCAAGGUGGGUGGAUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.999 0.01 -1.000 0.5 3 Click to see details
BRCA 0.623 0.29 0.500 0.33 3 Click to see details
UCEC 0.351 0.39 0.500 0.33 3 Click to see details
HNSC 0.049 0.46 -0.250 0.29 7 Click to see details
HNSC 0.049 0.46 -0.250 0.29 7 Click to see details
HNSC 0.049 0.46 -0.250 0.29 7 Click to see details
HNSC 0.049 0.46 -0.250 0.29 7 Click to see details
HNSC 0.049 0.46 -0.250 0.29 7 Click to see details
109 hsa-miR-1245a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006574 BRCA2 BRCA2, DNA repair associated 2 1
MIRT055432 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT063879 RASSF8 Ras association domain family member 8 2 6
MIRT077025 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT095775 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT099172 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT175616 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT456518 LYPLAL1 lysophospholipase like 1 2 2
MIRT464457 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465747 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT468257 SFXN4 sideroflexin 4 2 2
MIRT469216 RICTOR RPTOR independent companion of MTOR complex 2 2 2
MIRT472045 NPAT nuclear protein, coactivator of histone transcription 2 2
MIRT481795 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT500154 CREBBP CREB binding protein 2 2
MIRT506514 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 4
MIRT506915 KBTBD8 kelch repeat and BTB domain containing 8 2 6
MIRT513901 GRB10 growth factor receptor bound protein 10 2 6
MIRT519128 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT528121 FOXH1 forkhead box H1 2 2
MIRT528942 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT540580 CEP89 centrosomal protein 89 2 2
MIRT545858 ZNF264 zinc finger protein 264 2 4
MIRT547147 PGM3 phosphoglucomutase 3 2 2
MIRT547434 MED4 mediator complex subunit 4 2 2
MIRT554650 ROBO1 roundabout guidance receptor 1 2 2
MIRT558524 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT559762 ABHD5 abhydrolase domain containing 5 2 2
MIRT560438 GOLGA7B golgin A7 family member B 2 2
MIRT561974 LRRC59 leucine rich repeat containing 59 2 2
MIRT562442 DDIT4 DNA damage inducible transcript 4 2 2
MIRT563489 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT568265 BMP2K BMP2 inducible kinase 2 2
MIRT572522 KIAA0232 KIAA0232 2 2
MIRT612801 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT621533 ZNF507 zinc finger protein 507 2 2
MIRT625205 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT625615 ZNF84 zinc finger protein 84 2 2
MIRT629215 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629509 AS3MT arsenite methyltransferase 2 2
MIRT629769 STK25 serine/threonine kinase 25 2 2
MIRT630908 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT632508 RAB13 RAB13, member RAS oncogene family 2 2
MIRT636871 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637106 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637332 FAM9B family with sequence similarity 9 member B 2 2
MIRT637553 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637639 ZNF431 zinc finger protein 431 2 2
MIRT637836 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT638326 RNF11 ring finger protein 11 2 2
MIRT638393 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642450 CLUAP1 clusterin associated protein 1 2 2
MIRT642616 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT643133 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644324 NFKBID NFKB inhibitor delta 2 2
MIRT645150 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 2
MIRT645673 ADK adenosine kinase 2 2
MIRT646091 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT646858 SLC35E4 solute carrier family 35 member E4 2 2
MIRT650153 ZNF426 zinc finger protein 426 2 2
MIRT652483 TMEM181 transmembrane protein 181 2 2
MIRT653790 SIRPA signal regulatory protein alpha 2 2
MIRT655526 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT657077 JPH2 junctophilin 2 2 2
MIRT657322 HOOK3 hook microtubule tethering protein 3 2 2
MIRT662036 FUT2 fucosyltransferase 2 2 2
MIRT662322 ADM2 adrenomedullin 2 2 2
MIRT663211 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663559 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663937 ZNF554 zinc finger protein 554 2 2
MIRT664689 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT664709 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT665291 ZFP14 ZFP14 zinc finger protein 2 2
MIRT665572 TXNL1 thioredoxin like 1 2 2
MIRT667068 PAOX polyamine oxidase 2 2
MIRT667304 MYO5A myosin VA 2 2
MIRT667442 METTL14 methyltransferase like 14 2 2
MIRT668048 GTPBP10 GTP binding protein 10 2 2
MIRT669604 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT671088 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT674361 SLC35E3 solute carrier family 35 member E3 2 2
MIRT674962 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT676394 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676819 AGMAT agmatinase 2 2
MIRT676891 ENSA endosulfine alpha 2 2
MIRT677059 ZNF34 zinc finger protein 34 2 2
MIRT678424 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678735 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT678930 XPOT exportin for tRNA 2 2
MIRT678954 MYADM myeloid associated differentiation marker 2 2
MIRT679228 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679765 TLR6 toll like receptor 6 2 2
MIRT681992 HRH4 histamine receptor H4 2 2
MIRT687405 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT694570 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT698449 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT706406 HAS2 hyaluronan synthase 2 2 2
MIRT706582 ZNF432 zinc finger protein 432 2 2
MIRT706838 VHLL VHL like 2 2
MIRT706909 DVL3 dishevelled segment polarity protein 3 2 2
MIRT707052 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT708583 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708988 CABP4 calcium binding protein 4 2 2
MIRT713041 ADRA2B adrenoceptor alpha 2B 2 2
MIRT713731 SUCO SUN domain containing ossification factor 2 2
MIRT714968 RAB21 RAB21, member RAS oncogene family 2 2
MIRT717485 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT722826 KLK2 kallikrein related peptidase 2 2 2
MIRT723305 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (500nM)
hsa-miR-1245a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (1uM)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-1245a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission