miRTarBase - #MIRT629665


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pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol USP1   
Synonyms UBP
Description ubiquitin specific peptidase 1
Transcript NM_001017415   
Other Transcripts NM_001017416 , NM_003368   
Expression
Putative miRNA Targets on USP1
3'UTR of USP1
(miRNA target sites are highlighted)		 
>USP1|NM_001017415|3'UTR
   1 AGTGAGTGTATTTTCCTTGTGTATATATTAAACACACCCATACAAACATTGGTAAAGTTGATTACATCAAAGAATCTTTA
  81 GCTTATCTTTTGAAGCTACTGGATATTATTGGTCTCTCTAGGTTTTTATATAAATAGTGAAATTTGAATTACTGAAAACC
 161 ATGTTAATTTTTAGAACTCATTTTCCTCAGTAGAGACTAGTGATGCATTAGCTTCTGGGAACAAACTTGTATCGGTTCTT
 241 AATTAAATTATCCAAAACGGAGGCATTTAAACACTTGGATTTACACCAGTCTTTTGTGTTTGCTTTTTAAAATAAAGTGC
 321 TCGTATTTGTATTCTCCATATTTTGGAGTAATTATCTACATGATGTTTATAGTTCCTGTGGTTTTTCACCCAAGAAGCAG
 401 AATCTCATTCAGTACATTTAGTTTTATAAGAGTCATGAAGCTAAATCCTTGGGCTATGTCAGAGGCACAAAGTCTAGAAT
 481 GTGTGTATTCACAATGGTGTATGTACATTTTGTGCCTTGATTCACTTAGAAGTGTCTCAGAAAACCTGGACAGTTCGCTT
 561 CTACACAAGAATTTTATATGTATTTATGAAGATGATTCTGTACCCTAGTATATCTTTTTGGGCATGGACTAATTTGTATC
 641 TGTTTAACTCATATTCTGCACGATCTGTATATAGTACATCAAACTTAGAGGTGTGACCTTAAATTTAACTTTTTTTAAAA
 721 ACTGGGAGGTCAATAAAATTTAAACTGCTTAACTATGTATATGAATATTTGAATTTTTTACTTGTATATTTTTATAAATA
 801 CAGCTGAGTTTTCTTAAAGCGAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUCCGUCCAA-----GGACCUAGua 5'
            |||||  ||     |:|||||:  
Target 5' ggAGGCA-TTTAAACACTTGGATTta 3'
 259 - 283 118.00 -15.20
2 
miRNA  3' ucuccgUCCAAGGACCUAgua 5'
                | | | ||||||   
Target 5' cttttgAAGCTACTGGATatt 3'
 87 - 107 111.00 -7.32
3 
miRNA  3' ucuccGUCCAAGGACCUAGUa 5'
               :|| |||: ||| || 
Target 5' tgcatTAGCTTCTGGGAACAa 3'
 204 - 224 100.00 -7.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM9818204 2 COSMIC
COSN27004305 26 COSMIC
COSN30293125 61 COSMIC
COSN31556613 80 COSMIC
COSN31605044 127 COSMIC
COSN31521937 139 COSMIC
COSN30162548 155 COSMIC
COSN31558400 167 COSMIC
COSN31583668 175 COSMIC
COSN31559033 220 COSMIC
COSN30173114 265 COSMIC
COSN8476832 475 COSMIC
COSN31557612 524 COSMIC
COSN31564846 558 COSMIC
COSN30173554 717 COSMIC
COSN31593725 729 COSMIC
COSN31579125 808 COSMIC
rs583609 145 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs373386894 2 dbSNP
rs777856635 2 dbSNP
rs1342079409 3 dbSNP
rs748180217 4 dbSNP
rs749380149 6 dbSNP
rs771014890 6 dbSNP
rs771449575 9 dbSNP
rs1405295722 11 dbSNP
rs988816176 19 dbSNP
rs772825327 22 dbSNP
rs746592813 24 dbSNP
rs377081918 26 dbSNP
rs746092577 26 dbSNP
rs774505623 26 dbSNP
rs1436227544 27 dbSNP
rs777079121 31 dbSNP
rs772579570 32 dbSNP
rs534369538 34 dbSNP
rs1408926041 35 dbSNP
rs536354984 35 dbSNP
rs1284928816 36 dbSNP
rs1355653080 37 dbSNP
rs1208006422 40 dbSNP
rs1170357875 42 dbSNP
rs1286203483 44 dbSNP
rs991430485 49 dbSNP
rs188283168 50 dbSNP
rs7556103 53 dbSNP
rs889280195 59 dbSNP
rs1442671813 66 dbSNP
rs1211736853 69 dbSNP
rs1235249567 71 dbSNP
rs1472218340 75 dbSNP
rs1182251798 77 dbSNP
rs1413410070 78 dbSNP
rs981301159 80 dbSNP
rs1473842265 81 dbSNP
rs375630832 84 dbSNP
rs776683700 99 dbSNP
rs535702193 101 dbSNP
rs1384641741 104 dbSNP
rs1415266020 113 dbSNP
rs1314172078 114 dbSNP
rs1305069197 115 dbSNP
rs934609499 117 dbSNP
rs1350839896 119 dbSNP
rs990045769 121 dbSNP
rs62620019 130 dbSNP
rs583609 145 dbSNP
rs1401403196 175 dbSNP
rs1302921983 179 dbSNP
rs993485995 180 dbSNP
rs1361727055 181 dbSNP
rs912352174 187 dbSNP
rs1472694319 189 dbSNP
rs1414304072 198 dbSNP
rs943744726 207 dbSNP
rs369490564 208 dbSNP
rs1184764549 211 dbSNP
rs1474552968 212 dbSNP
rs1040552607 230 dbSNP
rs1026659794 233 dbSNP
rs895701359 234 dbSNP
rs993729188 235 dbSNP
rs1049324483 239 dbSNP
rs1330061470 239 dbSNP
rs554607033 241 dbSNP
rs1339817900 250 dbSNP
rs1313279449 255 dbSNP
rs1014125373 256 dbSNP
rs1382186625 259 dbSNP
rs1022784815 260 dbSNP
rs1319271889 266 dbSNP
rs1457494258 270 dbSNP
rs1345374303 287 dbSNP
rs969849691 290 dbSNP
rs1390736752 291 dbSNP
rs978940749 292 dbSNP
rs1161833922 298 dbSNP
rs1456663047 313 dbSNP
rs539629924 315 dbSNP
rs955910731 318 dbSNP
rs1023349753 319 dbSNP
rs561550197 323 dbSNP
rs914142345 324 dbSNP
rs1259802200 328 dbSNP
rs557998415 329 dbSNP
rs1441462959 337 dbSNP
rs1270184177 341 dbSNP
rs1465516857 341 dbSNP
rs1211611689 349 dbSNP
rs1355328796 353 dbSNP
rs1265775783 354 dbSNP
rs1205307128 360 dbSNP
rs1246959581 364 dbSNP
rs1253301806 382 dbSNP
rs933595323 387 dbSNP
rs1435110382 390 dbSNP
rs1366937487 394 dbSNP
rs763468652 396 dbSNP
rs369791546 398 dbSNP
rs1180582694 407 dbSNP
rs1381155952 410 dbSNP
rs910748860 410 dbSNP
rs943494711 411 dbSNP
rs1459951564 417 dbSNP
rs766862789 417 dbSNP
rs1478598120 418 dbSNP
rs899215718 419 dbSNP
rs1450110116 422 dbSNP
rs989972237 426 dbSNP
rs1197074410 427 dbSNP
rs1423380642 428 dbSNP
rs929303031 434 dbSNP
rs1211406125 436 dbSNP
rs773920663 440 dbSNP
rs1273756579 444 dbSNP
rs1228531744 446 dbSNP
rs573283206 448 dbSNP
rs181868123 456 dbSNP
rs895811152 457 dbSNP
rs41289442 465 dbSNP
rs1388823722 469 dbSNP
rs912178719 469 dbSNP
rs943813265 471 dbSNP
rs1372430671 475 dbSNP
rs1307916768 476 dbSNP
rs1022817358 478 dbSNP
rs905721820 485 dbSNP
rs767250265 489 dbSNP
rs1033182619 491 dbSNP
rs1170880716 494 dbSNP
rs1477860683 495 dbSNP
rs574806545 498 dbSNP
rs1200752863 502 dbSNP
rs955777028 504 dbSNP
rs988963468 509 dbSNP
rs1251032383 520 dbSNP
rs1328179805 524 dbSNP
rs1331599475 532 dbSNP
rs1029363170 534 dbSNP
rs1277651361 535 dbSNP
rs542111623 551 dbSNP
rs563561145 554 dbSNP
rs918324398 554 dbSNP
rs76903430 557 dbSNP
rs1349058494 558 dbSNP
rs987741692 570 dbSNP
rs1217545231 571 dbSNP
rs1411036100 579 dbSNP
rs1228627368 583 dbSNP
rs1276176100 585 dbSNP
rs910779936 591 dbSNP
rs1049209887 595 dbSNP
rs1174494984 602 dbSNP
rs964884621 604 dbSNP
rs1471715939 608 dbSNP
rs530757102 612 dbSNP
rs1473572382 615 dbSNP
rs376214012 615 dbSNP
rs34155906 629 dbSNP
rs1235602765 630 dbSNP
rs1203801269 637 dbSNP
rs973559324 640 dbSNP
rs1044416416 643 dbSNP
rs1280085059 643 dbSNP
rs907175353 645 dbSNP
rs1250507644 646 dbSNP
rs1002859858 649 dbSNP
rs1288189994 651 dbSNP
rs920760854 662 dbSNP
rs929442921 663 dbSNP
rs1048261790 668 dbSNP
rs1447434258 672 dbSNP
rs1341187564 675 dbSNP
rs1011456756 679 dbSNP
rs1021427590 681 dbSNP
rs953950051 682 dbSNP
rs1159640174 683 dbSNP
rs1458567762 689 dbSNP
rs1411571813 693 dbSNP
rs564068851 717 dbSNP
rs1473070698 721 dbSNP
rs1238757840 724 dbSNP
rs1186117503 732 dbSNP
rs528146881 734 dbSNP
rs950030380 737 dbSNP
rs912246001 742 dbSNP
rs759762277 746 dbSNP
rs1169399347 754 dbSNP
rs1288133265 754 dbSNP
rs1392252330 756 dbSNP
rs972412815 758 dbSNP
rs918368363 770 dbSNP
rs1321412251 774 dbSNP
rs1427970990 774 dbSNP
rs546279124 776 dbSNP
rs1167387723 787 dbSNP
rs1391416491 794 dbSNP
rs1044302472 795 dbSNP
rs909357573 798 dbSNP
rs1166187733 805 dbSNP
rs1415790421 805 dbSNP
rs1448297235 806 dbSNP
rs1321371201 807 dbSNP
rs1190156058 811 dbSNP
rs1487288691 815 dbSNP
rs187410026 821 dbSNP
rs1000438194 822 dbSNP
rs759626207 824 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000339950.4 | 3UTR | GCUGGUGGAUCACGAGGUCAGGAGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000339950.4 | 3UTR | AUCACGAGGUCAGGAGAUCGAGAUCAUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000339950.4 | 3UTR | AUCACGAGGUCAGGAGAUCGAGAUCAUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE26953 Aortic valvular endothelial cells -0.343 5.0e-2 -0.335 5.5e-2 24 Click to see details
GSE32688 Pancreatic cancer -0.248 8.6e-2 -0.355 2.3e-2 32 Click to see details
GSE27834 Pluripotent stem cells -0.311 1.2e-1 -0.247 1.8e-1 16 Click to see details
GSE17498 Multiple myeloma 0.154 1.7e-1 0.199 1.1e-1 40 Click to see details
GSE19350 CNS germ cell tumors -0.3 1.7e-1 -0.042 4.5e-1 12 Click to see details
GSE28544 Breast cancer -0.193 1.8e-1 -0.116 2.9e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.182 1.9e-1 0.214 1.5e-1 25 Click to see details
GSE14794 Lymphoblastoid cells -0.086 2.1e-1 -0.129 1.1e-1 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.158 2.5e-1 -0.056 4.1e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer -0.148 2.7e-1 -0.020 4.7e-1 20 Click to see details
GSE28260 Renal cortex and medulla 0.182 2.8e-1 0.169 2.9e-1 13 Click to see details
GSE21849 B cell lymphoma 0.108 2.9e-1 0.116 2.7e-1 29 Click to see details
GSE17306 Multiple myeloma 0.056 3.5e-1 0.231 5.5e-2 49 Click to see details
GSE42095 Differentiated embryonic stem cells 0.062 3.9e-1 0.000 5.0e-1 23 Click to see details
GSE19783 ER- ER- breast cancer -0.03 4.0e-1 -0.094 2.0e-1 79 Click to see details
GSE38226 Liver fibrosis -0.034 4.4e-1 -0.030 4.5e-1 21 Click to see details
GSE19536 Breast cancer -0.014 4.5e-1 -0.066 2.6e-1 100 Click to see details
GSE21687 Ependynoma primary tumors -0.005 4.8e-1 -0.052 3.4e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.008 4.8e-1 0.033 4.4e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.008 4.8e-1 0.033 4.4e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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