pre-miRNA Information
pre-miRNA hsa-mir-4680   
Genomic Coordinates chr10: 110898090 - 110898155
Description Homo sapiens miR-4680 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4680-5p
Sequence 5| AGAACUCUUGCAGUCUUAGAUGU |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1274530692 2 dbSNP
rs780271274 5 dbSNP
rs1461423681 7 dbSNP
rs749729920 8 dbSNP
rs1252920446 10 dbSNP
rs201739274 11 dbSNP
rs774971106 19 dbSNP
rs748132091 22 dbSNP
rs773643180 22 dbSNP
rs1235425484 23 dbSNP
Putative Targets

Gene Information
Gene Symbol IDE   
Synonyms INSULYSIN
Description insulin degrading enzyme
Transcript NM_001165946   
Other Transcripts NM_004969   
Expression
Putative miRNA Targets on IDE
3'UTR of IDE
(miRNA target sites are highlighted)
>IDE|NM_001165946|3'UTR
   1 AGATTCCCCATGCATGGGAAAGTGCAAGTGGATGCATTCCTGAGTCTTCCAGAGCCTAAGAAAATCATCTTGGCCACTTT
  81 AATAGTTTCTGATTCACTATTAGAGAAACAAACAAAAAATTGTCAAATGTCATTATGTAGAAATATTATAAATCCAAAGT
 161 AAATTACAAAATCTTATAGATGTAGAATATTTTTTAAATACATGCCTCTTAAATATTTTAAAATTTTTCTTTTGATTACT
 241 GAGAGAAATTTCCCCAATATAACAATGCTTAAAATGAATGATATTCCTATAGAATCTTCCTTCCCTATTCTGTAAAATAG
 321 TCACTTGTCCGAAGAAAGTTAAAAGTTAGCTCTTTTCTAAAAGCCTCCTAGCTTGACATAGAAGGCTTCACAACATTTAG
 401 AAAGGTAATAACTTTTTAAAAATTGATCCTCAAATTTGCTTTCTACTTGATGGTTTCATGTAAATCAGTGGAAAACATTA
 481 CATTTGGCAGATGATAAAGCAATGTCATCTTTTATTAGTGAAATGCTGGTTATATAAGGCATGGTTTTAATCTTTTTATA
 561 AAATTTGAACATGTTTTTTATGCCAACTCGTAAAATGCTAGAAAACCCTACTTATTTACAATGCTAGAAATACAGACTTA
 641 CCTTACATCAATTTTGTCCTAAACCGAATTTCTCAGGATTACTGTGGTTTCTTTCATTCTGATTGAATTATATTGACCTA
 721 CTTCTTCATAGTTGGTTTGCAGTGTTCCATGAGTTTTACTTTTCCTCATCAACATATTGCTTTAACACAACATATTTATT
 801 TAACACGTACAAATAGGGTCAACTTCAGATCCTACTGAGTGTGTGACATGCTTTTCCAACATCAGCTTTTTGTAACCACC
 881 TGTATAACTTTTTATTACAGTGAAATTGCAGTCAGTATGTGAACCAAAATATCTTGCCCCTTTATGAATTTAAAAGGCAG
 961 CCAATACAAAGCCACCTTTTTGGAAATATAAAAAGTAAAGCCTTGCATTCTTATATAGCAGGTCTTCATAAAACTCTAAA
1041 ATCCCTTGTTGCTACCAGTCTAATCTTGCCTTAAATGTTAAGTTATTTTTTGAATATATAAATATAAACATATAAACACA
1121 GATGATGACTGGAGTAGACTTTTAAAAAAATATTTTTTTCATGAGATACTATTTTAGGTGAAATTGTTACTGTAGATTTA
1201 ACAGCTGTTTTGAAATATTTACTGTTATTAAAACTTGCTTCAAGAGAAATTGTGAATATATTTCCATATACAAGCACTAG
1281 TAACAGTAAGTGGCCCTGTCATCCACTAACTCAGGCAAAGTAAAGAATGGCATTTTTGAAGGACATTTTACCTCCCCATA
1361 TGATTTGATTGGCTAGGACTTTCTTCTGTAAAGTCATACCTTTTCACATCTTAAGTTTTTACATTTGCCATTTTCCAAAT
1441 CTCAATTTTGGGCAAGAACGATATAGTCACAACTATGGGGCTGCTTTCAAAAGCGGGGCTCCATTTCTACTGTCAGATCA
1521 ATGTGGTGCTGTAACCATCTTTTTATCCCTACCTTCAAGAACCTCCTTATATGAAGCCTGTCTTTATCCATCAGAAGGTG
1601 TGTGAAATCATCACTTCCTTCTGGTTTTATGTATTTGTAGACTATGCAGCTTTTCATTAAACTGCAAGTATATACAAGAC
1681 AGATCTGAAATTAGGCCTGAGTGTTCCGATCCACCACTGTACTAGTAAATAAAAATCCACCTACCTTTTATGTGGAAAAT
1761 TATGTGCTATTGAGTAACTTTTAGCTCTTTTTTAAAAAATGGGTGAAATTTAAGTGTCTTTTTTATGAGAATGACACATG
1841 AAGAGATCTGAGAGCAATCTCATGTAGTCTTCCATGAACCTGCAATTGTTTGGTATGCGTCAGCATTTTCCAATTTCCAG
1921 GTTGGATCTAGAGCTGCTGTTGATCACTCAGGCATACTAATGGATTCATTTAGATGGGTCCAAGCTGCAGTCCATGAGCA
2001 ATAACAGACTACCCCAGATACTGCAGTTTACGCAGTGCTTAGTAAATGAGATTTGTGGAACTAAGTTATTAGTTACCTGA
2081 GGCTTCTTAAGAAAGTCTTCTTTTTTGACCAGTTGATGTGAAAGAGGGAGCATGTGACACAGCCAGTATGGTGGAGTGCT
2161 AGGGTTATCCTGTTTACAATAAATCGCCTGAATTTCACCTCTGGAGTCTGCATTTGTATTATTTTTCCAGTTTTAGTGAA
2241 ATAGTACAGTGGCCAGTCCTCAGCCTACCTCTCAACATCCCAGTTTGACCAGATTTCTTGCTTTCATTGTTCATAATGCA
2321 GAAAGCAGTGAATTATATTAACATTTTAAAAGTGTTTCTGGGTAACAATGATTTTTGTCAAATAGAAGACTCAATTTCAC
2401 AACCTTAAGAATAGATCACTTTTGTAAAACAAGAATCTCAGTATTTGATGTTGGACTCCTTGCTGTGAGTATTGTCACTG
2481 ACTCCAAACCCAGAAAGATTTGTTCCTGCCCTTACAGGGATGAAAATAAAAAGGATAGAAAAAATATTTCTCTCCTCTAC
2561 AATGAGTCCTTACATCTTCTTGCCACATCTCCAGCTGCAGTTTAGGCAGATATCTTGTTCAATCTCTGTCTTCTTGATCC
2641 CTGTCAAAATAATTTTTCTACTCATATAGTGGCCAGTTGGCTCAGGCAGGCATTTCAAGAGGAATCTGCTTGTTCCTCAC
2721 TTTTCCAGCATAGGACAGTGGTCCAGCCCGCACAGTCAGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugUAGAUUCUGA--CG--UUCUCAAGa 5'
            ||||:| |:|  ||  :|| |||| 
Target 5' agATCTGAAATTAGGCCTGAGTGTTCc 3'
1681 - 1707 133.00 -9.70
2
miRNA  3' ugUAGAUUCUGAC-GUUCUCAAGa 5'
            |||  || :|| | ||| ||| 
Target 5' acATCCCAGTTTGACCAGATTTCt 3'
2275 - 2298 129.00 -11.20
3
miRNA  3' ugUAGAUUCUGACGUUCUCAAga 5'
            ||   :|| ||| ||:|||  
Target 5' gtATGGTGGAGTGCTAGGGTTat 3'
2146 - 2168 125.00 -11.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30470601 6 COSMIC
COSN26639517 13 COSMIC
COSN30155168 95 COSMIC
COSN30149544 97 COSMIC
COSN508711 103 COSMIC
COSN513140 676 COSMIC
COSN7075357 732 COSMIC
COSN8726363 760 COSMIC
COSN5822510 767 COSMIC
COSN16744103 777 COSMIC
COSN15236095 1010 COSMIC
COSN21629401 1134 COSMIC
COSN1507034 1422 COSMIC
COSN30056274 2259 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770778578 5 dbSNP
rs745609637 7 dbSNP
rs778742376 14 dbSNP
rs1201727145 15 dbSNP
rs902932056 18 dbSNP
rs757469229 22 dbSNP
rs746951491 30 dbSNP
rs764397617 37 dbSNP
rs775782751 44 dbSNP
rs756104289 47 dbSNP
rs1376036803 51 dbSNP
rs1057078117 53 dbSNP
rs1169658465 57 dbSNP
rs1315528647 60 dbSNP
rs530042114 69 dbSNP
rs939636997 71 dbSNP
rs926262968 78 dbSNP
rs1348973532 84 dbSNP
rs777511635 88 dbSNP
rs1433613741 107 dbSNP
rs1304482200 115 dbSNP
rs561150280 116 dbSNP
rs1218537757 117 dbSNP
rs1276681468 123 dbSNP
rs962415236 127 dbSNP
rs1215530286 130 dbSNP
rs909673132 132 dbSNP
rs1320169017 134 dbSNP
rs758393572 141 dbSNP
rs747563821 147 dbSNP
rs542222525 160 dbSNP
rs1292643886 180 dbSNP
rs778615442 181 dbSNP
rs1192932050 183 dbSNP
rs1240299452 189 dbSNP
rs750964463 190 dbSNP
rs1186910940 202 dbSNP
rs982626184 208 dbSNP
rs1039574184 219 dbSNP
rs190205178 238 dbSNP
rs1029517581 239 dbSNP
rs1320726298 244 dbSNP
rs1418571966 245 dbSNP
rs943973291 259 dbSNP
rs998483318 265 dbSNP
rs1431875553 267 dbSNP
rs142121592 276 dbSNP
rs1377211001 283 dbSNP
rs1047053227 289 dbSNP
rs112269616 290 dbSNP
rs1353007648 297 dbSNP
rs920039756 311 dbSNP
rs974256360 312 dbSNP
rs1282002157 318 dbSNP
rs186189948 324 dbSNP
rs903932061 325 dbSNP
rs545937333 330 dbSNP
rs111424778 331 dbSNP
rs916767146 342 dbSNP
rs1009657851 358 dbSNP
rs1385475623 360 dbSNP
rs112536877 366 dbSNP
rs992381429 372 dbSNP
rs182862939 384 dbSNP
rs1156330015 385 dbSNP
rs960954025 387 dbSNP
rs1056645580 389 dbSNP
rs1401842344 393 dbSNP
rs939583814 405 dbSNP
rs1404437829 411 dbSNP
rs34266748 418 dbSNP
rs58175459 418 dbSNP
rs1315918628 423 dbSNP
rs1376463760 425 dbSNP
rs1238026579 429 dbSNP
rs926899021 431 dbSNP
rs1196502234 433 dbSNP
rs1450758356 474 dbSNP
rs576922661 476 dbSNP
rs1281388587 477 dbSNP
rs557160802 481 dbSNP
rs977123194 489 dbSNP
rs1215163100 500 dbSNP
rs1044708967 502 dbSNP
rs1277843232 508 dbSNP
rs1456105770 532 dbSNP
rs1459757976 532 dbSNP
rs45533535 534 dbSNP
rs1243325610 535 dbSNP
rs909558866 538 dbSNP
rs1179013522 539 dbSNP
rs982898342 543 dbSNP
rs929756685 552 dbSNP
rs1172447297 556 dbSNP
rs574810511 564 dbSNP
rs1471131424 565 dbSNP
rs1272370350 574 dbSNP
rs1399795066 584 dbSNP
rs754649695 589 dbSNP
rs1011345395 590 dbSNP
rs922416058 596 dbSNP
rs1336361584 604 dbSNP
rs1435848392 609 dbSNP
rs1274133650 621 dbSNP
rs1330875391 624 dbSNP
rs964192348 630 dbSNP
rs77798559 637 dbSNP
rs1316923007 646 dbSNP
rs1398331741 647 dbSNP
rs963954062 650 dbSNP
rs534616509 665 dbSNP
rs187455375 666 dbSNP
rs758568303 668 dbSNP
rs757640047 681 dbSNP
rs1177590493 686 dbSNP
rs1423419838 687 dbSNP
rs994606071 695 dbSNP
rs1477608311 710 dbSNP
rs1169803900 711 dbSNP
rs181824914 713 dbSNP
rs1022312960 714 dbSNP
rs1386232851 716 dbSNP
rs1377967127 718 dbSNP
rs1010036432 721 dbSNP
rs1406767379 723 dbSNP
rs1283674337 727 dbSNP
rs892578063 734 dbSNP
rs373827857 738 dbSNP
rs1437468158 743 dbSNP
rs1339717051 750 dbSNP
rs1208692551 758 dbSNP
rs1289037935 769 dbSNP
rs1035578446 779 dbSNP
rs1200708862 785 dbSNP
rs1038837189 790 dbSNP
rs1427066115 794 dbSNP
rs1195807137 797 dbSNP
rs1003753658 803 dbSNP
rs948175403 806 dbSNP
rs569744008 807 dbSNP
rs1198741977 809 dbSNP
rs1056646567 816 dbSNP
rs905445029 827 dbSNP
rs550032795 837 dbSNP
rs1275798551 844 dbSNP
rs941618119 848 dbSNP
rs1199227928 851 dbSNP
rs1380265040 857 dbSNP
rs529879772 858 dbSNP
rs1297505207 860 dbSNP
rs1326647540 865 dbSNP
rs1244861091 876 dbSNP
rs924222253 884 dbSNP
rs977099943 891 dbSNP
rs1046756350 895 dbSNP
rs929698208 901 dbSNP
rs967427216 906 dbSNP
rs1207232803 908 dbSNP
rs561187437 918 dbSNP
rs34872659 930 dbSNP
rs1344807375 937 dbSNP
rs1181921373 964 dbSNP
rs914257842 966 dbSNP
rs1445275444 971 dbSNP
rs922416515 979 dbSNP
rs1451624576 980 dbSNP
rs976985458 983 dbSNP
rs1385324444 989 dbSNP
rs990275227 990 dbSNP
rs1281537713 995 dbSNP
rs1236895069 1000 dbSNP
rs963769368 1002 dbSNP
rs1308720080 1019 dbSNP
rs1305723518 1024 dbSNP
rs1315654867 1026 dbSNP
rs1018061549 1028 dbSNP
rs942478148 1029 dbSNP
rs1443109606 1034 dbSNP
rs1261838616 1035 dbSNP
rs1461101219 1044 dbSNP
rs547328257 1045 dbSNP
rs1332171462 1046 dbSNP
rs1413808265 1054 dbSNP
rs1008049446 1059 dbSNP
rs1245149137 1065 dbSNP
rs911062886 1070 dbSNP
rs955279659 1077 dbSNP
rs1402773974 1082 dbSNP
rs548048322 1086 dbSNP
rs968634705 1098 dbSNP
rs1417569848 1100 dbSNP
rs1379304565 1105 dbSNP
rs1364343580 1108 dbSNP
rs1469054868 1109 dbSNP
rs1022702282 1110 dbSNP
rs988180430 1113 dbSNP
rs1453005468 1115 dbSNP
rs148234245 1115 dbSNP
rs5786997 1115 dbSNP
rs1370466207 1118 dbSNP
rs1392634838 1118 dbSNP
rs1308291929 1130 dbSNP
rs528495178 1144 dbSNP
rs1222045908 1148 dbSNP
rs1265457916 1151 dbSNP
rs994115615 1159 dbSNP
rs1204017720 1160 dbSNP
rs1231397026 1161 dbSNP
rs1481635343 1165 dbSNP
rs1186180260 1166 dbSNP
rs1442375127 1173 dbSNP
rs1035145389 1178 dbSNP
rs1252419364 1184 dbSNP
rs898460963 1189 dbSNP
rs1003590437 1194 dbSNP
rs1431238956 1195 dbSNP
rs751955048 1198 dbSNP
rs764465685 1219 dbSNP
rs1352437651 1223 dbSNP
rs1258766226 1225 dbSNP
rs1463031071 1228 dbSNP
rs199630007 1238 dbSNP
rs1213478029 1250 dbSNP
rs1345404483 1252 dbSNP
rs1403696532 1256 dbSNP
rs1285766455 1266 dbSNP
rs1023775096 1267 dbSNP
rs1214378805 1274 dbSNP
rs1012706513 1280 dbSNP
rs1271087197 1281 dbSNP
rs1351957726 1290 dbSNP
rs895269793 1295 dbSNP
rs1205268426 1301 dbSNP
rs1383772123 1306 dbSNP
rs562116037 1320 dbSNP
rs1352986863 1330 dbSNP
rs888722447 1358 dbSNP
rs763535216 1360 dbSNP
rs1478212675 1367 dbSNP
rs1056637168 1369 dbSNP
rs1416924352 1386 dbSNP
rs1429975608 1390 dbSNP
rs1170515647 1395 dbSNP
rs939527671 1397 dbSNP
rs1047168727 1398 dbSNP
rs924125782 1400 dbSNP
rs929691594 1411 dbSNP
rs900845469 1412 dbSNP
rs1286680387 1413 dbSNP
rs559535564 1414 dbSNP
rs1356025620 1415 dbSNP
rs1364344886 1420 dbSNP
rs942446865 1439 dbSNP
rs117136179 1451 dbSNP
rs1042938066 1452 dbSNP
rs947266795 1454 dbSNP
rs913648 1459 dbSNP
rs988539757 1460 dbSNP
rs548709893 1461 dbSNP
rs765340283 1470 dbSNP
rs963756342 1471 dbSNP
rs1240211039 1473 dbSNP
rs563406135 1475 dbSNP
rs1188723527 1480 dbSNP
rs1162145636 1490 dbSNP
rs554179242 1494 dbSNP
rs531695471 1495 dbSNP
rs1415117935 1500 dbSNP
rs1400704161 1505 dbSNP
rs371741835 1510 dbSNP
rs986578911 1512 dbSNP
rs1190679508 1521 dbSNP
rs1487540885 1551 dbSNP
rs190690602 1554 dbSNP
rs1262885450 1562 dbSNP
rs377536440 1576 dbSNP
rs969474807 1586 dbSNP
rs144336862 1587 dbSNP
rs1287918490 1629 dbSNP
rs866669124 1630 dbSNP
rs1227814049 1631 dbSNP
rs1005715049 1633 dbSNP
rs962660730 1640 dbSNP
rs1223083303 1641 dbSNP
rs1282067943 1644 dbSNP
rs1017343562 1647 dbSNP
rs1209141876 1648 dbSNP
rs1012285993 1649 dbSNP
rs1242117379 1663 dbSNP
rs1216695632 1665 dbSNP
rs397846480 1666 dbSNP
rs5786996 1666 dbSNP
rs1025864344 1670 dbSNP
rs1289257439 1674 dbSNP
rs543687539 1675 dbSNP
rs1469194872 1682 dbSNP
rs1157274544 1685 dbSNP
rs1035124783 1692 dbSNP
rs1458051123 1701 dbSNP
rs1003644986 1702 dbSNP
rs1176227104 1705 dbSNP
rs1322473236 1707 dbSNP
rs1461563022 1708 dbSNP
rs902650885 1716 dbSNP
rs1334911780 1719 dbSNP
rs1335174652 1741 dbSNP
rs1042566005 1752 dbSNP
rs1393697350 1766 dbSNP
rs572698641 1773 dbSNP
rs1040748380 1791 dbSNP
rs1419362274 1793 dbSNP
rs1006630485 1794 dbSNP
rs946958849 1799 dbSNP
rs1352807067 1800 dbSNP
rs143868751 1800 dbSNP
rs1228746132 1802 dbSNP
rs1423472344 1807 dbSNP
rs1187482833 1814 dbSNP
rs1320952867 1815 dbSNP
rs1205106045 1825 dbSNP
rs558299958 1832 dbSNP
rs1054516497 1836 dbSNP
rs1245269119 1837 dbSNP
rs942395556 1840 dbSNP
rs1235081386 1848 dbSNP
rs201514982 1851 dbSNP
rs1473230118 1861 dbSNP
rs116215967 1866 dbSNP
rs1468998932 1874 dbSNP
rs986483884 1892 dbSNP
rs1173333568 1897 dbSNP
rs569784502 1898 dbSNP
rs149625416 1899 dbSNP
rs773083554 1905 dbSNP
rs138530687 1910 dbSNP
rs540781100 1913 dbSNP
rs1296128140 1920 dbSNP
rs1282574156 1931 dbSNP
rs1343339748 1933 dbSNP
rs962937484 1942 dbSNP
rs938615367 1944 dbSNP
rs927956179 1946 dbSNP
rs1193542615 1947 dbSNP
rs1216184547 1948 dbSNP
rs1483662825 1952 dbSNP
rs147543592 1957 dbSNP
rs990799744 1962 dbSNP
rs1481593424 1974 dbSNP
rs1200080330 1976 dbSNP
rs368137978 1985 dbSNP
rs185838963 1988 dbSNP
rs1372685865 2005 dbSNP
rs959333538 2012 dbSNP
rs1035028805 2014 dbSNP
rs1003592607 2021 dbSNP
rs902638941 2022 dbSNP
rs1273931528 2028 dbSNP
rs1021533500 2032 dbSNP
rs916698970 2033 dbSNP
rs527618146 2036 dbSNP
rs1302428005 2042 dbSNP
rs1363662693 2053 dbSNP
rs952874613 2062 dbSNP
rs1441145378 2063 dbSNP
rs1026253143 2066 dbSNP
rs1325487052 2068 dbSNP
rs369276184 2069 dbSNP
rs1011103331 2073 dbSNP
rs571502774 2077 dbSNP
rs1342197834 2086 dbSNP
rs894031593 2095 dbSNP
rs1290188290 2097 dbSNP
rs1490994353 2098 dbSNP
rs1039264709 2100 dbSNP
rs552303969 2107 dbSNP
rs142973122 2132 dbSNP
rs111832344 2138 dbSNP
rs190481257 2139 dbSNP
rs1195513050 2145 dbSNP
rs1019269954 2146 dbSNP
rs889414796 2155 dbSNP
rs1444032486 2163 dbSNP
rs374054391 2164 dbSNP
rs933740328 2169 dbSNP
rs751226118 2175 dbSNP
rs1459443695 2185 dbSNP
rs889529282 2186 dbSNP
rs1021350700 2190 dbSNP
rs1430723664 2196 dbSNP
rs918375097 2204 dbSNP
rs181404062 2220 dbSNP
rs1011743140 2233 dbSNP
rs891602674 2241 dbSNP
rs1312360864 2242 dbSNP
rs763685080 2246 dbSNP
rs1454892910 2252 dbSNP
rs972963144 2259 dbSNP
rs778566287 2277 dbSNP
rs941225642 2282 dbSNP
rs1348934445 2290 dbSNP
rs909723582 2292 dbSNP
rs7896688 2305 dbSNP
rs1248857198 2306 dbSNP
rs748823674 2331 dbSNP
rs907154316 2332 dbSNP
rs1245107744 2335 dbSNP
rs1424490705 2348 dbSNP
rs927950011 2350 dbSNP
rs762479699 2351 dbSNP
rs775019211 2352 dbSNP
rs1165318852 2356 dbSNP
rs779788279 2357 dbSNP
rs967183708 2360 dbSNP
rs1206511080 2362 dbSNP
rs1451325365 2364 dbSNP
rs948023518 2380 dbSNP
rs1310260846 2383 dbSNP
rs1334296121 2384 dbSNP
rs769323261 2386 dbSNP
rs984149220 2394 dbSNP
rs1011427576 2403 dbSNP
rs1334562084 2417 dbSNP
rs1277695367 2420 dbSNP
rs958205085 2422 dbSNP
rs1269238429 2426 dbSNP
rs1323077236 2448 dbSNP
rs931404206 2456 dbSNP
rs1017735128 2469 dbSNP
rs535197996 2476 dbSNP
rs751818565 2484 dbSNP
rs1007725489 2489 dbSNP
rs890746482 2490 dbSNP
rs73323652 2493 dbSNP
rs879571859 2498 dbSNP
rs1306545804 2502 dbSNP
rs973332290 2505 dbSNP
rs1445485703 2506 dbSNP
rs896877198 2509 dbSNP
rs1412360944 2513 dbSNP
rs79359916 2515 dbSNP
rs1173763325 2522 dbSNP
rs1299289006 2523 dbSNP
rs561366334 2526 dbSNP
rs541594868 2535 dbSNP
rs572686079 2536 dbSNP
rs1360560609 2545 dbSNP
rs1466086591 2546 dbSNP
rs941117176 2547 dbSNP
rs1463948413 2550 dbSNP
rs1357887790 2552 dbSNP
rs1173427424 2553 dbSNP
rs1371810089 2554 dbSNP
rs1289542216 2559 dbSNP
rs1435658443 2559 dbSNP
rs909678784 2561 dbSNP
rs537468985 2562 dbSNP
rs1055006843 2564 dbSNP
rs1397196117 2571 dbSNP
rs559172255 2572 dbSNP
rs985715748 2582 dbSNP
rs953653932 2586 dbSNP
rs927895413 2591 dbSNP
rs545045853 2593 dbSNP
rs139055590 2594 dbSNP
rs1252490468 2596 dbSNP
rs753269335 2609 dbSNP
rs1178984081 2613 dbSNP
rs1482249453 2630 dbSNP
rs1433480579 2636 dbSNP
rs913906686 2638 dbSNP
rs748974415 2642 dbSNP
rs989545901 2642 dbSNP
rs556304064 2646 dbSNP
rs1309130046 2657 dbSNP
rs958365544 2660 dbSNP
rs1211334847 2664 dbSNP
rs536392756 2665 dbSNP
rs1007716953 2667 dbSNP
rs1295719827 2672 dbSNP
rs1283509111 2675 dbSNP
rs1368555467 2676 dbSNP
rs1031501434 2683 dbSNP
rs954942836 2691 dbSNP
rs1030561610 2692 dbSNP
rs1003154693 2702 dbSNP
rs994171952 2703 dbSNP
rs1490177811 2723 dbSNP
rs1317026828 2727 dbSNP
rs1219103805 2731 dbSNP
rs907053906 2734 dbSNP
rs896788235 2738 dbSNP
rs1308550406 2746 dbSNP
rs1044253923 2749 dbSNP
rs765286930 2750 dbSNP
rs1385149480 2752 dbSNP
rs78350622 2755 dbSNP
rs1350761980 2756 dbSNP
rs77670925 2757 dbSNP
rs1287281656 2759 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uguagauucugacGUUCUCAAGa 5'
                       ||:|||||| 
Target 5' ---------ugguCAGGAGUUCa 3'
1 - 14
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000265986.6 | 3UTR | UGGUCAGGAGUUCAAGACCAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
133 hsa-miR-4680-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT378771 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT393867 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT446684 C2CD2 C2 calcium dependent domain containing 2 2 2
MIRT447600 MRPL3 mitochondrial ribosomal protein L3 2 2
MIRT450708 RNF152 ring finger protein 152 2 2
MIRT450784 PAPOLG poly(A) polymerase gamma 2 2
MIRT454623 COL23A1 collagen type XXIII alpha 1 chain 2 8
MIRT461620 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT462695 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT475530 HOXA3 homeobox A3 2 8
MIRT475739 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT489676 CYP1A1 cytochrome P450 family 1 subfamily A member 1 2 2
MIRT490610 SLC47A1 solute carrier family 47 member 1 2 2
MIRT493628 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT496152 RPS15A ribosomal protein S15a 2 2
MIRT499232 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT501496 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT507163 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT512389 MTRNR2L1 MT-RNR2-like 1 2 4
MIRT514626 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT517474 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT525332 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT526685 BAK1 BCL2 antagonist/killer 1 2 2
MIRT527317 CCR2 C-C motif chemokine receptor 2 2 2
MIRT527608 EYS eyes shut homolog (Drosophila) 2 2
MIRT528794 RAB32 RAB32, member RAS oncogene family 2 2
MIRT531048 TIPARP TCDD inducible poly(ADP-ribose) polymerase 2 2
MIRT532254 TBPL2 TATA-box binding protein like 2 2 2
MIRT533801 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT535887 MLEC malectin 2 2
MIRT540704 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT544645 PHF8 PHD finger protein 8 2 4
MIRT545760 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT555310 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT555877 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT559507 ARID5B AT-rich interaction domain 5B 2 2
MIRT560448 SLC30A7 solute carrier family 30 member 7 2 2
MIRT561262 ZIK1 zinc finger protein interacting with K protein 1 2 2
MIRT561795 PAWR pro-apoptotic WT1 regulator 2 2
MIRT567007 KLHL15 kelch like family member 15 2 2
MIRT569298 SURF6 surfeit 6 2 2
MIRT570606 MTRNR2L11 MT-RNR2-like 11 2 2
MIRT572888 ADCY2 adenylate cyclase 2 2 2
MIRT573119 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 2 2
MIRT608332 ZNF670 zinc finger protein 670 2 6
MIRT614942 KCNK5 potassium two pore domain channel subfamily K member 5 2 2
MIRT615324 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT618441 ZNF800 zinc finger protein 800 2 2
MIRT620110 HARBI1 harbinger transposase derived 1 2 2
MIRT626008 ZNF517 zinc finger protein 517 2 2
MIRT626626 SLC30A6 solute carrier family 30 member 6 2 2
MIRT627842 POU3F1 POU class 3 homeobox 1 2 2
MIRT628386 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT629305 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT629864 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630444 IDE insulin degrading enzyme 2 2
MIRT631854 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT633173 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT633477 ZNF724P zinc finger protein 724 2 2
MIRT634395 PLSCR1 phospholipid scramblase 1 2 2
MIRT635538 TRIM72 tripartite motif containing 72 2 2
MIRT635821 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT636169 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636797 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT637952 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT645136 HES2 hes family bHLH transcription factor 2 2 2
MIRT645667 ADK adenosine kinase 2 2
MIRT646148 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT647004 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT648187 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT650090 TERF2 telomeric repeat binding factor 2 2 2
MIRT650329 RTN2 reticulon 2 2 2
MIRT654224 RNF165 ring finger protein 165 2 2
MIRT654545 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT656457 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT656828 KLF8 Kruppel like factor 8 2 2
MIRT657112 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein like 2 2 2
MIRT657930 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT659375 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659833 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT662108 LACTB lactamase beta 2 4
MIRT662789 TBC1D25 TBC1 domain family member 25 2 2
MIRT669501 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT669759 ZNF101 zinc finger protein 101 2 4
MIRT669800 GAN gigaxonin 2 2
MIRT670050 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670299 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670388 EMP2 epithelial membrane protein 2 2 2
MIRT672862 C22orf29 retrotransposon Gag like 10 2 2
MIRT672890 FXN frataxin 2 2
MIRT673210 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT674001 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674163 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674502 TIRAP TIR domain containing adaptor protein 2 2
MIRT675470 NUBPL nucleotide binding protein like 2 2
MIRT675671 TMOD2 tropomodulin 2 2 2
MIRT676006 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676074 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676386 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676764 SNX2 sorting nexin 2 2 2
MIRT676896 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT676978 ZNF708 zinc finger protein 708 2 2
MIRT677236 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677369 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677464 PDLIM3 PDZ and LIM domain 3 2 2
MIRT678081 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678093 ATCAY ATCAY, caytaxin 2 2
MIRT678324 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678417 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678521 ZNF347 zinc finger protein 347 2 2
MIRT678700 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT678829 PDE6A phosphodiesterase 6A 2 2
MIRT679991 RUNDC1 RUN domain containing 1 2 2
MIRT680751 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT681249 ZNF383 zinc finger protein 383 2 2
MIRT681422 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT681948 SLC19A3 solute carrier family 19 member 3 2 2
MIRT689278 C5AR2 complement component 5a receptor 2 2 2
MIRT690389 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT691845 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT693863 IYD iodotyrosine deiodinase 2 2
MIRT696002 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT701930 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT702341 KLHL7 kelch like family member 7 2 2
MIRT703557 FKBP14 FK506 binding protein 14 2 2
MIRT705033 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT706341 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT709671 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT711212 EFHB EF-hand domain family member B 2 2
MIRT718342 PURA purine rich element binding protein A 2 2
MIRT722755 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723535 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT724498 BFAR bifunctional apoptosis regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4680-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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