pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol CENPM   
Synonyms C22orf18, CENP-M, PANE1
Description centromere protein M
Transcript NM_001002876   
Other Transcripts NM_001110215 , NM_024053   
Expression
Putative miRNA Targets on CENPM
3'UTR of CENPM
(miRNA target sites are highlighted)
>CENPM|NM_001002876|3'UTR
   1 GGCCACCATGGCGCAGCGCCTGGTGCGCGTGCTGCAGATCTGTGCTGGCCACGTGCCCGGTGTCTCAGCTCTGAACCTGC
  81 TGTCCCTGCTGAGAAGCTCTGAGGGCCCCTCCCTGGAGGACCTGTGAGGGTGGCTGGCCCCTGGGCTGCCCCTTCTCATG
 161 GCTTCGTGCTGACTCCATAAACATTCTCTGTTGAGGATGTCCAGTCAGGGCTTGACAGGCCCAGGCTCAGCCCGCCGTGG
 241 CTGGGAAGGTTCCCTGCAGTGCCAGTGCTGCAGCAGGGAGAGCTGGGCAGAAGCAGCGAGGGGGCCCAGCTGGCGAGACT
 321 GTAGCCCCCTCCCACTCCCACACTCACTCTTGCAGAGCCTGTGTCTTTAAGCAGCTGGCGTGTTACATCTCCATTTAAGG
 401 TTTCCTTTGAACAAAAGGTCTGTGGCTAAAAAAAGTTTAAAAATCACTGGTCTCATTCACCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aguGUCAAC--GGUCGACUCUaau 5'
             | | ||  || |||||||   
Target 5' aacCTGCTGTCCCTGCTGAGAagc 3'
74 - 97 121.00 -12.82
2
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            ||| || :| |:||||: | 
Target 5' aaACA-TTCTCTGTTGAGGATg 3'
179 - 199 115.00 -11.10
3
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            ||| |  ||| :| ||:|| 
Target 5' ttACA-TCTCCATTTAAGGTTt 3'
383 - 403 111.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6004942 13 COSMIC
COSM4634807 16 COSMIC
COSM479016 18 COSMIC
COSM8490242 28 COSMIC
COSM1200757 53 COSMIC
COSM4969276 56 COSMIC
COSM7312790 58 COSMIC
COSM3555002 73 COSMIC
COSM6626650 79 COSMIC
COSM5393762 84 COSMIC
COSM3694093 100 COSMIC
COSM9681920 109 COSMIC
COSM4156339 115 COSMIC
COSM8866702 124 COSMIC
COSN30490478 128 COSMIC
COSN26970385 134 COSMIC
COSN31511170 141 COSMIC
COSN30145946 165 COSMIC
COSN31544997 184 COSMIC
COSN24407276 195 COSMIC
COSN31512806 195 COSMIC
COSN30455389 208 COSMIC
COSN30480845 208 COSMIC
COSN30540774 214 COSMIC
COSN19663856 234 COSMIC
COSN31537257 237 COSMIC
COSN30013177 355 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1380654513 1 dbSNP
rs1338851973 5 dbSNP
rs749496721 7 dbSNP
rs773521621 8 dbSNP
rs376664319 12 dbSNP
rs762296545 12 dbSNP
rs549021345 13 dbSNP
rs1414516617 14 dbSNP
rs1398689664 16 dbSNP
rs750063789 17 dbSNP
rs781072264 18 dbSNP
rs1443987169 21 dbSNP
rs374540211 26 dbSNP
rs371185369 27 dbSNP
rs1049408107 28 dbSNP
rs994685502 29 dbSNP
rs143638439 31 dbSNP
rs894941464 33 dbSNP
rs1319077309 34 dbSNP
rs757973961 37 dbSNP
rs138055602 40 dbSNP
rs765008124 42 dbSNP
rs1353249302 51 dbSNP
rs756847529 51 dbSNP
rs767807033 52 dbSNP
rs760069349 53 dbSNP
rs569652175 58 dbSNP
rs774792724 59 dbSNP
rs774949456 63 dbSNP
rs1346722453 69 dbSNP
rs766762973 70 dbSNP
rs764711908 73 dbSNP
rs763157368 77 dbSNP
rs1165406597 78 dbSNP
rs1423837779 80 dbSNP
rs773148657 88 dbSNP
rs945161784 90 dbSNP
rs1184386568 92 dbSNP
rs1486677355 95 dbSNP
rs914989724 96 dbSNP
rs770064281 98 dbSNP
rs1478103242 101 dbSNP
rs748314408 109 dbSNP
rs1192424437 111 dbSNP
rs776598765 114 dbSNP
rs762484483 117 dbSNP
rs570248268 119 dbSNP
rs746777274 122 dbSNP
rs780183010 123 dbSNP
rs1362878251 130 dbSNP
rs1426858010 136 dbSNP
rs377466334 138 dbSNP
rs373230417 139 dbSNP
rs756942871 145 dbSNP
rs1404040871 149 dbSNP
rs368867350 150 dbSNP
rs767893562 156 dbSNP
rs1458394221 159 dbSNP
rs977047627 160 dbSNP
rs775132155 162 dbSNP
rs755387483 165 dbSNP
rs376167757 166 dbSNP
rs763306762 172 dbSNP
rs750517475 173 dbSNP
rs765189565 177 dbSNP
rs546315747 179 dbSNP
rs901118819 183 dbSNP
rs1015638569 186 dbSNP
rs533074775 187 dbSNP
rs1235851483 193 dbSNP
rs778552332 197 dbSNP
rs1456899248 198 dbSNP
rs1178908362 204 dbSNP
rs1163433545 214 dbSNP
rs1446100380 216 dbSNP
rs1472045834 218 dbSNP
rs1004214636 221 dbSNP
rs1039582365 222 dbSNP
rs952654174 230 dbSNP
rs909713151 231 dbSNP
rs984614631 233 dbSNP
rs1047997 234 dbSNP
rs1013391749 235 dbSNP
rs1243251711 236 dbSNP
rs1283399183 237 dbSNP
rs894999622 237 dbSNP
rs547235734 248 dbSNP
rs1284036852 256 dbSNP
rs982112784 257 dbSNP
rs1235091828 266 dbSNP
rs1256042951 271 dbSNP
rs1033914634 280 dbSNP
rs970701668 288 dbSNP
rs1003445884 295 dbSNP
rs1023923439 298 dbSNP
rs906451412 304 dbSNP
rs1047656542 308 dbSNP
rs1186326883 312 dbSNP
rs1042075170 314 dbSNP
rs945043820 315 dbSNP
rs1169227990 328 dbSNP
rs1423525337 329 dbSNP
rs1466273175 332 dbSNP
rs1032475885 341 dbSNP
rs893426473 345 dbSNP
rs1400086739 349 dbSNP
rs1395694768 359 dbSNP
rs1000363111 361 dbSNP
rs1340885190 368 dbSNP
rs902908241 379 dbSNP
rs529394910 380 dbSNP
rs1053553100 395 dbSNP
rs550647730 405 dbSNP
rs1252565494 409 dbSNP
rs1342195196 412 dbSNP
rs921465847 422 dbSNP
rs1278869122 434 dbSNP
rs567949798 435 dbSNP
rs1191954420 436 dbSNP
rs6002547 439 dbSNP
rs368784804 445 dbSNP
rs1478443122 447 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agugucaaCGGUCGACUC-Uaau 5'
                  |||  | ||| |   
Target 5' cugccucaGCCUCCCGAGCAgcu 3'
11 - 33
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000404067.1 | 3UTR | AGUGAUUCUCCUGCCUCAGCCUCCCGAGCAGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000404067.1 | 3UTR | AUUACACCACUGCACUCCAGCCUGGGCAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000404067.1 | 3UTR | AUUACACCACUGCACUCCAGCCUGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000404067.1 | 3UTR | AUUACACCACUGCACUCCAGCCUGGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells -0.748 2.0e-5 -0.711 7.2e-5 23 Click to see details
GSE17306 Multiple myeloma 0.33 1.0e-2 0.555 1.7e-5 49 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.439 1.4e-2 0.343 4.7e-2 25 Click to see details
GSE19350 CNS germ cell tumors 0.621 1.6e-2 0.659 9.9e-3 12 Click to see details
GSE28260 Renal cortex and medulla -0.57 2.1e-2 -0.540 2.8e-2 13 Click to see details
GSE21849 B cell lymphoma 0.299 5.8e-2 0.351 3.1e-2 29 Click to see details
GSE32688 Pancreatic cancer -0.267 7.0e-2 -0.311 4.2e-2 32 Click to see details
GSE27834 Pluripotent stem cells 0.312 1.2e-1 0.315 1.2e-1 16 Click to see details
GSE17498 Multiple myeloma 0.14 1.9e-1 0.243 6.5e-2 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.178 2.3e-1 -0.087 3.6e-1 20 Click to see details
GSE28544 Breast cancer 0.147 2.5e-1 0.122 2.9e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.122 2.9e-1 0.108 3.1e-1 24 Click to see details
GSE21687 Ependynoma primary tumors -0.055 3.3e-1 -0.442 1.3e-4 64 Click to see details
GSE14794 Lymphoblastoid cells -0.026 4.0e-1 -0.025 4.1e-1 90 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.038 4.3e-1 0.475 8.2e-3 25 Click to see details
GSE38226 Liver fibrosis 0.025 4.6e-1 0.337 6.8e-2 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUAD 0.769 0.01 0.617 0.04 9 Click to see details
BLCA 0.668 0.02 0.612 0.03 10 Click to see details
PAAD -0.873 0.06 -0.800 0.1 4 Click to see details
LIHC 0.228 0.07 0.077 0.31 45 Click to see details
LUSC 0.299 0.1 0.236 0.16 20 Click to see details
HNSC -0.259 0.12 -0.134 0.27 23 Click to see details
CHOL -0.417 0.15 -0.333 0.21 8 Click to see details
KIRC -0.191 0.16 0.002 0.5 29 Click to see details
BRCA -0.18 0.19 -0.149 0.24 25 Click to see details
KICH -0.199 0.28 -0.355 0.14 11 Click to see details
KIRP -0.117 0.32 -0.092 0.36 18 Click to see details
STAD 0.099 0.34 0.032 0.45 20 Click to see details
PRAD 0.07 0.35 0.169 0.18 31 Click to see details
THCA 0.044 0.38 0.056 0.35 47 Click to see details
ESCA -0.194 0.4 0.000 0.5 4 Click to see details
UCEC 0.084 0.41 0.006 0.49 10 Click to see details
UCEC 0.084 0.41 0.006 0.49 10 Click to see details
UCEC 0.084 0.41 0.006 0.49 10 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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