pre-miRNA Information | |
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pre-miRNA | hsa-mir-6751 |
Genomic Coordinates | chr11: 65129916 - 65129978 |
Description | Homo sapiens miR-6751 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-6751-3p | ||||||||||||||||||||||||||||||
Sequence | 43| ACUGAGCCUCUCUCUCUCCAG |63 | ||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||
Experiments | Meta-analysis | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | KLHL21 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | kelch like family member 21 | ||||||||||||||||||||
Transcript | NM_014851 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on KLHL21 | |||||||||||||||||||||
3'UTR of KLHL21 (miRNA target sites are highlighted) |
>KLHL21|NM_014851|3'UTR 1 CCCCAGTCTGGCCCGGCACGGGCCTCGGTGCAGGTAACTGGCACCTCTGCGGGGCAGTGCCCCACTCCTTTGTGCACAAG 81 GACACGTTGGGCTCACAGGAGGAGCACAGGCTCTTGGGTGGCGAAGCCAGCCCAGGATCCATTACCTGGAAGGTTTCTGT 161 ACCTTGAGAGCCTGAATCAGAGGCCGTCGGGAACGCCCTCCCTGCAGTTGAGGAAGAGCCACTTTCCTGCCAGCACATGT 241 TTCTGGGTCTTGGAGGTCACCCCCACCCCGCGGATCACAGCTCACCCACGCGGCGCACACCCCTCCTGCCGTTGTCATCT 321 GCACCTACTTGTTCCCACCTTGGGAGAGGACGATGACTTGGGAGGGACGCGTGAAGGGAGAAGGGGTCCTCCCATGAGGC 401 TGAGGATGGCCTGAACCTGGAGCAGCGGACCAGGCAGACGGGCTGAAGTGGGGTCCCAAATTCCATGTCCAGAGGTGTGG 481 GGAGCCTGCCTCCCTAGCTCCTGGCCCCTGCCAGGGGCTTACATCAAAACACCTCAGAGGGCTGCCCTCCAGAGGCTGCA 561 CCCAGAACAGTGGGACATGAGCAGGGGTGTGGGCTTGGAGGGTGAAGAGGATGTGGTCCTATCAGATGCTGGGCCTCCTC 641 AGCCATAGCCCCCTGCTCCTACCCCCTGACTGGCTCTTGCGTCCTCACCTCTCACCCTCTCCTTCCCGGGAGGCCCTGGG 721 AGGTGATCATTGACACCCAGCCAAGCAGACAGCTGCGGGTGCCCAAGCCCTTGCTGGGCCTGCGCGTGAGGAGTCCCACT 801 GCTTCTAAAGGAAGTCCTGGGCAGGAGGTGGCTTTGGTGGTTGGTTCCAAAGTTGAAAATGCTTGCAGTTTGACCTTAGA 881 AGAAGTGGGAAGAAGAAGGAGCTCTACAGGGTCAGCTTTGTTTGATTTGTCCAGTCTAAGAAGTCCCATTGCCAAAGCTT 961 TCTGCAGGAGGGTGAATGCCGCAGCTTGGCAGCCCCTGGGTTTCTCTTGGAAATGGTCAGTTTCCCCTCAAAGTACCCAA 1041 AGTAGCCTTGGCTTGAGTTTTTGTCCTTGCCTCCTTTTTAGAGAAGAGGGCATTTAGACTGCATTTTCCTGGTTAAAGAA 1121 GGTTAAAGCAAATGTTTATTGCCTTTTCTAGTGAACTAACTCGTAGAGATGTTCTCAGCAGGAAGACAGTCTTAGCACTG 1201 TCACTTAGCAGATTGCACTTAAGTCCCTTGTGCTGGCCAGATGGCGTGGCTGGTTGCCTTAATATGTCCCAGGACCCCTG 1281 ACAGGGCTGCCTGGCCTCTCCCTCGTGCTCCTCAAGAGCCCAGTCCATACACTGTGGATGTCATTGCTGTCGGGTTAGGA 1361 AGTCTTGTCCTAGAACGCCCTGGCTGGTATGACCACAGTTCATGGCGGCTCTTCTCGCTTGGGTCATGGTCATCTTCCAG 1441 CACCTGCTGTGCTGGGAAGGCCGAGGATGGGGGCCCAGCACTGTCCAGGCCTGCTGGGGCCTGGCTGGGAGTCCTGTGGG 1521 CAGCATGGAACATGCAGCTGGGCTTCCTGTGACCAGGCACCCTCTGGCACTGTTGCTTGCCCTGTGCCCTGGACCTTTTC 1601 CTGCCCTTCTCCTTCCTCTGCTCCCTTGGGGCTACCCCTTGGCCCCTCCTGGTCTGTGCAAACTCCCTCAGGGAGCCCCC 1681 CTGCCCTGTAGCTCTCGCTTAACTTCCTAGGGGCTGCTGAGCCCACCCAGAGGTTGTTGGAGTTCAGCGGGGCAGCTTGT 1761 CTCCCTTGTCAGCAGGGGCGTAAGGGCTGGGTTTGGCCATACAAGGTTGGCTACGCCCTCAATCCCTGACCGTTCCAGGC 1841 ACTGAGCTGGGCACCCACGGAAGGACATGCTGTCCAGACTGTGATGACTGCCAGCACAGGGCATCTCGGGCTTGGCTGGT 1921 CTGCGAGGCCTTGCCCCTGTGGAACTCTGGGTTCCTGTTTTCTCAGTCTTTTTTGCGGCTTTGCTGTGGTTGGCAGCTGC 2001 CGTACTCCAGGCTTGTGTCGGCCACTCAGATGAGGGCTGTGGTGCGAGCCAGTGCAGGAGAGCTGCGCTTGGGATTGTGC 2081 CCTCTCCTGTGTCTGTCCTCCGGACCTACCCAGGTCTCCACCATCAGGACCCTGTCTTTGGGTTTAGAAGACCAAGTATG 2161 GGGAAAACCAGGCACCAGCCTCTGCAGCAATGGGTCCCTCTAGCCTGTGGACACCAGCTGGGGGATCCAGGGTCAGGCCC 2241 CCTCCTCTCCCCAGTTTCCCTCTGCTGTGGGTTCTGGGCTGTCATGTCTCCACCACTTAAGGATGTCTTTACACTGACTT 2321 CAGGATAGATGCTGGGATGCCTGGGCATGGCCACATGTTACATGTACAGAACTTTGTCTACAGCACAAATTAAGTTATAT 2401 AAACACAGTGACTGGTATTTAATGCTGATCTACTATAAGGTATTCTATATTTATATGACTTCAGAGACGCGTATGTAATA 2481 AAGGACGCCCTCCCTCCAGTGTCCACATCCAGTTCACCCCAGAGGGTCGGGCAGGTTGACATATTTATTTTTGTCTATTC 2561 TGTAGGCTTCCATGTCCAGAATCCTGCTTAAGGTTTTAGGGTACCTTCAGTACTTTTTGCAATAAAAGTATTTCCTATCC 2641 AAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293S | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4
HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
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CLIP-seq Support 1 for dataset GSM1084046 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_noarsenite_rep4 |
Location of target site | ENST00000377663.3 | 3UTR | CCUGGCUCAGCCUCCCAAAGUGCUGGGAUUACAGGC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM1084073 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_hippuristanol_rep1_AbnovaAb |
Location of target site | ENST00000377663.3 | 3UTR | GGCUCAGCCUCCCAAAGU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT130738 | GATAD2B | GATA zinc finger domain containing 2B | ![]() |
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2 | 4 | ||||||
MIRT134924 | CCND2 | cyclin D2 | ![]() |
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2 | 2 | ||||||
MIRT273034 | ZBTB18 | zinc finger and BTB domain containing 18 | ![]() |
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2 | 2 | ||||||
MIRT276645 | KPNA3 | karyopherin subunit alpha 3 | ![]() |
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2 | 6 | ||||||
MIRT446531 | OAS2 | 2'-5'-oligoadenylate synthetase 2 | ![]() |
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2 | 2 | ||||||
MIRT456268 | TDRKH | tudor and KH domain containing | ![]() |
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2 | 12 | ||||||
MIRT494454 | BTG2 | BTG anti-proliferation factor 2 | ![]() |
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2 | 2 | ||||||
MIRT494965 | USP46 | ubiquitin specific peptidase 46 | ![]() |
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2 | 2 | ||||||
MIRT496689 | KREMEN1 | kringle containing transmembrane protein 1 | ![]() |
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2 | 2 | ||||||
MIRT496697 | RGS11 | regulator of G protein signaling 11 | ![]() |
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2 | 2 | ||||||
MIRT504376 | IRF4 | interferon regulatory factor 4 | ![]() |
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2 | 6 | ||||||
MIRT510980 | PFN2 | profilin 2 | ![]() |
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2 | 6 | ||||||
MIRT512548 | MFN2 | mitofusin 2 | ![]() |
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2 | 6 | ||||||
MIRT513639 | TP53INP2 | tumor protein p53 inducible nuclear protein 2 | ![]() |
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2 | 2 | ||||||
MIRT514016 | CAMSAP1 | calmodulin regulated spectrin associated protein 1 | ![]() |
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2 | 4 | ||||||
MIRT514074 | MTRNR2L6 | MT-RNR2-like 6 | ![]() |
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2 | 2 | ||||||
MIRT515300 | C15orf38-AP3S2 | C15orf38-AP3S2 readthrough | ![]() |
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2 | 4 | ||||||
MIRT517285 | AP3S2 | adaptor related protein complex 3 sigma 2 subunit | ![]() |
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2 | 4 | ||||||
MIRT519075 | KCNK6 | potassium two pore domain channel subfamily K member 6 | ![]() |
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2 | 2 | ||||||
MIRT520779 | TCF23 | transcription factor 23 | ![]() |
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2 | 2 | ||||||
MIRT522485 | MFSD9 | major facilitator superfamily domain containing 9 | ![]() |
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2 | 2 | ||||||
MIRT528856 | PKP1 | plakophilin 1 | ![]() |
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2 | 2 | ||||||
MIRT529081 | PATE2 | prostate and testis expressed 2 | ![]() |
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2 | 2 | ||||||
MIRT531209 | PLA2G4D | phospholipase A2 group IVD | ![]() |
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2 | 2 | ||||||
MIRT533988 | TAB3 | TGF-beta activated kinase 1 and MAP3K7 binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT537024 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | ![]() |
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2 | 2 | ||||||
MIRT537498 | FAM168B | family with sequence similarity 168 member B | ![]() |
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2 | 2 | ||||||
MIRT553125 | UBE2Z | ubiquitin conjugating enzyme E2 Z | ![]() |
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2 | 2 | ||||||
MIRT555591 | PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase type 1 gamma | ![]() |
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2 | 2 | ||||||
MIRT556370 | LUZP1 | leucine zipper protein 1 | ![]() |
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2 | 2 | ||||||
MIRT569745 | C2orf71 | chromosome 2 open reading frame 71 | ![]() |
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2 | 2 | ||||||
MIRT570149 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | ![]() |
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2 | 2 | ||||||
MIRT571243 | FADS6 | fatty acid desaturase 6 | ![]() |
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2 | 2 | ||||||
MIRT573065 | TRIB1 | tribbles pseudokinase 1 | ![]() |
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2 | 2 | ||||||
MIRT575533 | Map4 | microtubule-associated protein 4 | ![]() |
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2 | 2 | ||||||
MIRT575777 | Tnfrsf10b | tumor necrosis factor receptor superfamily, member 10b | ![]() |
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2 | 2 | ||||||
MIRT616558 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 2 | ||||||
MIRT624851 | ABI2 | abl interactor 2 | ![]() |
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2 | 2 | ||||||
MIRT630078 | GRWD1 | glutamate rich WD repeat containing 1 | ![]() |
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2 | 2 | ||||||
MIRT631479 | KLHL21 | kelch like family member 21 | ![]() |
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2 | 2 | ||||||
MIRT632173 | CCL22 | C-C motif chemokine ligand 22 | ![]() |
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2 | 2 | ||||||
MIRT638397 | QSOX2 | quiescin sulfhydryl oxidase 2 | ![]() |
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2 | 4 | ||||||
MIRT641192 | ISG20L2 | interferon stimulated exonuclease gene 20 like 2 | ![]() |
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2 | 2 | ||||||
MIRT642562 | TEX9 | testis expressed 9 | ![]() |
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2 | 2 | ||||||
MIRT642935 | KRTAP5-9 | keratin associated protein 5-9 | ![]() |
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2 | 2 | ||||||
MIRT649703 | ZNF175 | zinc finger protein 175 | ![]() |
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2 | 2 | ||||||
MIRT650437 | CPXM2 | carboxypeptidase X, M14 family member 2 | ![]() |
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2 | 2 | ||||||
MIRT652113 | TRUB2 | TruB pseudouridine synthase family member 2 | ![]() |
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2 | 2 | ||||||
MIRT652273 | TOMM20 | translocase of outer mitochondrial membrane 20 | ![]() |
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2 | 2 | ||||||
MIRT655215 | PFKM | phosphofructokinase, muscle | ![]() |
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2 | 2 | ||||||
MIRT682778 | ZNF852 | zinc finger protein 852 | ![]() |
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2 | 2 | ||||||
MIRT683001 | MUC20 | mucin 20, cell surface associated | ![]() |
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2 | 2 | ||||||
MIRT684320 | GTF3C4 | general transcription factor IIIC subunit 4 | ![]() |
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2 | 2 | ||||||
MIRT689435 | CYB561 | cytochrome b561 | ![]() |
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2 | 2 | ||||||
MIRT693847 | ZNF107 | zinc finger protein 107 | ![]() |
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2 | 2 | ||||||
MIRT696715 | TAX1BP3 | Tax1 binding protein 3 | ![]() |
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2 | 2 | ||||||
MIRT698597 | TEX261 | testis expressed 261 | ![]() |
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2 | 2 | ||||||
MIRT699973 | RREB1 | ras responsive element binding protein 1 | ![]() |
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2 | 2 | ||||||
MIRT703310 | GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | ![]() |
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2 | 2 | ||||||
MIRT706796 | RAI1 | retinoic acid induced 1 | ![]() |
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2 | 2 | ||||||
MIRT709004 | CD109 | CD109 molecule | ![]() |
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2 | 2 | ||||||
MIRT709181 | TBC1D10B | TBC1 domain family member 10B | ![]() |
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2 | 2 | ||||||
MIRT709835 | PAQR7 | progestin and adipoQ receptor family member 7 | ![]() |
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2 | 2 | ||||||
MIRT711627 | CORO1C | coronin 1C | ![]() |
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2 | 2 | ||||||
MIRT712634 | RNF103-CHMP3 | RNF103-CHMP3 readthrough | ![]() |
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2 | 2 | ||||||
MIRT713694 | CYB5R4 | cytochrome b5 reductase 4 | ![]() |
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2 | 2 | ||||||
MIRT713752 | SLC9A8 | solute carrier family 9 member A8 | ![]() |
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2 | 2 | ||||||
MIRT714908 | CHMP3 | charged multivesicular body protein 3 | ![]() |
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2 | 2 | ||||||
MIRT716371 | CBLL1 | Cbl proto-oncogene like 1 | ![]() |
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2 | 2 | ||||||
MIRT718303 | XPOT | exportin for tRNA | ![]() |
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2 | 2 | ||||||
MIRT718713 | ANKRD18A | ankyrin repeat domain 18A | ![]() |
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2 | 2 | ||||||
MIRT718740 | ATP9A | ATPase phospholipid transporting 9A (putative) | ![]() |
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2 | 2 | ||||||
MIRT719441 | NPTX2 | neuronal pentraxin 2 | ![]() |
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2 | 2 | ||||||
MIRT720896 | OTUD4 | OTU deubiquitinase 4 | ![]() |
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2 | 2 | ||||||
MIRT722448 | RXFP4 | relaxin/insulin like family peptide receptor 4 | ![]() |
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2 | 2 | ||||||
MIRT723882 | VKORC1 | vitamin K epoxide reductase complex subunit 1 | ![]() |
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2 | 2 | ||||||
MIRT724586 | SYNJ2BP | synaptojanin 2 binding protein | ![]() |
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2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||
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