pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol KLHL21   
Synonyms -
Description kelch like family member 21
Transcript NM_014851   
Expression
Putative miRNA Targets on KLHL21
3'UTR of KLHL21
(miRNA target sites are highlighted)
>KLHL21|NM_014851|3'UTR
   1 CCCCAGTCTGGCCCGGCACGGGCCTCGGTGCAGGTAACTGGCACCTCTGCGGGGCAGTGCCCCACTCCTTTGTGCACAAG
  81 GACACGTTGGGCTCACAGGAGGAGCACAGGCTCTTGGGTGGCGAAGCCAGCCCAGGATCCATTACCTGGAAGGTTTCTGT
 161 ACCTTGAGAGCCTGAATCAGAGGCCGTCGGGAACGCCCTCCCTGCAGTTGAGGAAGAGCCACTTTCCTGCCAGCACATGT
 241 TTCTGGGTCTTGGAGGTCACCCCCACCCCGCGGATCACAGCTCACCCACGCGGCGCACACCCCTCCTGCCGTTGTCATCT
 321 GCACCTACTTGTTCCCACCTTGGGAGAGGACGATGACTTGGGAGGGACGCGTGAAGGGAGAAGGGGTCCTCCCATGAGGC
 401 TGAGGATGGCCTGAACCTGGAGCAGCGGACCAGGCAGACGGGCTGAAGTGGGGTCCCAAATTCCATGTCCAGAGGTGTGG
 481 GGAGCCTGCCTCCCTAGCTCCTGGCCCCTGCCAGGGGCTTACATCAAAACACCTCAGAGGGCTGCCCTCCAGAGGCTGCA
 561 CCCAGAACAGTGGGACATGAGCAGGGGTGTGGGCTTGGAGGGTGAAGAGGATGTGGTCCTATCAGATGCTGGGCCTCCTC
 641 AGCCATAGCCCCCTGCTCCTACCCCCTGACTGGCTCTTGCGTCCTCACCTCTCACCCTCTCCTTCCCGGGAGGCCCTGGG
 721 AGGTGATCATTGACACCCAGCCAAGCAGACAGCTGCGGGTGCCCAAGCCCTTGCTGGGCCTGCGCGTGAGGAGTCCCACT
 801 GCTTCTAAAGGAAGTCCTGGGCAGGAGGTGGCTTTGGTGGTTGGTTCCAAAGTTGAAAATGCTTGCAGTTTGACCTTAGA
 881 AGAAGTGGGAAGAAGAAGGAGCTCTACAGGGTCAGCTTTGTTTGATTTGTCCAGTCTAAGAAGTCCCATTGCCAAAGCTT
 961 TCTGCAGGAGGGTGAATGCCGCAGCTTGGCAGCCCCTGGGTTTCTCTTGGAAATGGTCAGTTTCCCCTCAAAGTACCCAA
1041 AGTAGCCTTGGCTTGAGTTTTTGTCCTTGCCTCCTTTTTAGAGAAGAGGGCATTTAGACTGCATTTTCCTGGTTAAAGAA
1121 GGTTAAAGCAAATGTTTATTGCCTTTTCTAGTGAACTAACTCGTAGAGATGTTCTCAGCAGGAAGACAGTCTTAGCACTG
1201 TCACTTAGCAGATTGCACTTAAGTCCCTTGTGCTGGCCAGATGGCGTGGCTGGTTGCCTTAATATGTCCCAGGACCCCTG
1281 ACAGGGCTGCCTGGCCTCTCCCTCGTGCTCCTCAAGAGCCCAGTCCATACACTGTGGATGTCATTGCTGTCGGGTTAGGA
1361 AGTCTTGTCCTAGAACGCCCTGGCTGGTATGACCACAGTTCATGGCGGCTCTTCTCGCTTGGGTCATGGTCATCTTCCAG
1441 CACCTGCTGTGCTGGGAAGGCCGAGGATGGGGGCCCAGCACTGTCCAGGCCTGCTGGGGCCTGGCTGGGAGTCCTGTGGG
1521 CAGCATGGAACATGCAGCTGGGCTTCCTGTGACCAGGCACCCTCTGGCACTGTTGCTTGCCCTGTGCCCTGGACCTTTTC
1601 CTGCCCTTCTCCTTCCTCTGCTCCCTTGGGGCTACCCCTTGGCCCCTCCTGGTCTGTGCAAACTCCCTCAGGGAGCCCCC
1681 CTGCCCTGTAGCTCTCGCTTAACTTCCTAGGGGCTGCTGAGCCCACCCAGAGGTTGTTGGAGTTCAGCGGGGCAGCTTGT
1761 CTCCCTTGTCAGCAGGGGCGTAAGGGCTGGGTTTGGCCATACAAGGTTGGCTACGCCCTCAATCCCTGACCGTTCCAGGC
1841 ACTGAGCTGGGCACCCACGGAAGGACATGCTGTCCAGACTGTGATGACTGCCAGCACAGGGCATCTCGGGCTTGGCTGGT
1921 CTGCGAGGCCTTGCCCCTGTGGAACTCTGGGTTCCTGTTTTCTCAGTCTTTTTTGCGGCTTTGCTGTGGTTGGCAGCTGC
2001 CGTACTCCAGGCTTGTGTCGGCCACTCAGATGAGGGCTGTGGTGCGAGCCAGTGCAGGAGAGCTGCGCTTGGGATTGTGC
2081 CCTCTCCTGTGTCTGTCCTCCGGACCTACCCAGGTCTCCACCATCAGGACCCTGTCTTTGGGTTTAGAAGACCAAGTATG
2161 GGGAAAACCAGGCACCAGCCTCTGCAGCAATGGGTCCCTCTAGCCTGTGGACACCAGCTGGGGGATCCAGGGTCAGGCCC
2241 CCTCCTCTCCCCAGTTTCCCTCTGCTGTGGGTTCTGGGCTGTCATGTCTCCACCACTTAAGGATGTCTTTACACTGACTT
2321 CAGGATAGATGCTGGGATGCCTGGGCATGGCCACATGTTACATGTACAGAACTTTGTCTACAGCACAAATTAAGTTATAT
2401 AAACACAGTGACTGGTATTTAATGCTGATCTACTATAAGGTATTCTATATTTATATGACTTCAGAGACGCGTATGTAATA
2481 AAGGACGCCCTCCCTCCAGTGTCCACATCCAGTTCACCCCAGAGGGTCGGGCAGGTTGACATATTTATTTTTGTCTATTC
2561 TGTAGGCTTCCATGTCCAGAATCCTGCTTAAGGTTTTAGGGTACCTTCAGTACTTTTTGCAATAAAAGTATTTCCTATCC
2641 AAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacCUCUCUCUCUCCGAGUCa 5'
             ||| || :|:||| ||| 
Target 5' gccGAG-GATGGGGGCCCAGc 3'
1460 - 1479 129.00 -15.40
2
miRNA  3' gaCCUCUCUC-UCUCCGAGuca 5'
            |||| ||| | ||||||   
Target 5' caGGAG-GAGCACAGGCTCttg 3'
96 - 116 126.00 -17.72
3
miRNA  3' gacCUCUCUCUCUCCGAGUCa 5'
             |:|:||   ||| |||| 
Target 5' gctGGGGGATCCAGGGTCAGg 3'
2217 - 2237 126.00 -19.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30473133 3 COSMIC
COSN26981710 34 COSMIC
COSN26981711 51 COSMIC
COSN16863377 57 COSMIC
COSN16940141 195 COSMIC
COSN6464627 680 COSMIC
COSN6464626 707 COSMIC
COSN1452439 1363 COSMIC
COSN6464623 1697 COSMIC
COSN16004418 1909 COSMIC
COSN20094217 1969 COSMIC
COSN25631076 2071 COSMIC
COSN24967996 2093 COSMIC
COSN5743011 2175 COSMIC
COSN22164125 2339 COSMIC
COSN15292274 2341 COSMIC
COSN16348216 2392 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs377276646 1 dbSNP
rs770184255 2 dbSNP
rs1289362214 3 dbSNP
rs374292340 5 dbSNP
rs781097466 11 dbSNP
rs371099946 13 dbSNP
rs751851649 14 dbSNP
rs376195825 15 dbSNP
rs754825029 16 dbSNP
rs753562914 19 dbSNP
rs377537456 20 dbSNP
rs1479577221 22 dbSNP
rs760500033 24 dbSNP
rs749999473 26 dbSNP
rs766962294 27 dbSNP
rs774001863 28 dbSNP
rs768243229 30 dbSNP
rs1346390244 31 dbSNP
rs981790321 32 dbSNP
rs1276095591 33 dbSNP
rs1179056192 34 dbSNP
rs749497823 36 dbSNP
rs763362965 37 dbSNP
rs201663664 38 dbSNP
rs770370942 39 dbSNP
rs908293146 40 dbSNP
rs1429756400 41 dbSNP
rs1317426579 42 dbSNP
rs1414947861 45 dbSNP
rs1208439697 46 dbSNP
rs373921277 50 dbSNP
rs368737518 51 dbSNP
rs1225013603 60 dbSNP
rs952570594 60 dbSNP
rs987098835 65 dbSNP
rs1028595929 67 dbSNP
rs954478408 74 dbSNP
rs1318318451 79 dbSNP
rs531955822 83 dbSNP
rs1278514268 85 dbSNP
rs11811607 86 dbSNP
rs575651447 92 dbSNP
rs1320795860 97 dbSNP
rs1019550864 108 dbSNP
rs1413157727 113 dbSNP
rs777790336 117 dbSNP
rs549662495 122 dbSNP
rs755966938 123 dbSNP
rs1405196006 127 dbSNP
rs1021705041 128 dbSNP
rs1388503197 130 dbSNP
rs1296271144 141 dbSNP
rs1444047219 149 dbSNP
rs1465608590 157 dbSNP
rs1012114671 158 dbSNP
rs1250495917 161 dbSNP
rs1355091013 177 dbSNP
rs894625143 178 dbSNP
rs527934091 180 dbSNP
rs548994144 185 dbSNP
rs780899154 186 dbSNP
rs371853612 188 dbSNP
rs74049690 194 dbSNP
rs1046062679 197 dbSNP
rs545412937 198 dbSNP
rs1397818431 202 dbSNP
rs1365639171 204 dbSNP
rs939657277 205 dbSNP
rs908243025 207 dbSNP
rs1014203825 212 dbSNP
rs1349170944 213 dbSNP
rs983867019 225 dbSNP
rs1324310054 227 dbSNP
rs1406009364 238 dbSNP
rs560743615 239 dbSNP
rs578162244 246 dbSNP
rs931082736 249 dbSNP
rs895946683 256 dbSNP
rs1047786798 263 dbSNP
rs1189777845 264 dbSNP
rs1481148930 269 dbSNP
rs562989987 270 dbSNP
rs1202319980 271 dbSNP
rs899343653 272 dbSNP
rs544343328 275 dbSNP
rs1490689968 287 dbSNP
rs1463004562 289 dbSNP
rs573788361 290 dbSNP
rs555223365 291 dbSNP
rs1019498817 292 dbSNP
rs796580371 292 dbSNP
rs910796660 294 dbSNP
rs1304386977 295 dbSNP
rs113764508 297 dbSNP
rs969960084 299 dbSNP
rs41278024 303 dbSNP
rs1307734457 304 dbSNP
rs189473278 306 dbSNP
rs530864532 311 dbSNP
rs1174434978 318 dbSNP
rs1414229146 319 dbSNP
rs987899797 322 dbSNP
rs1202205773 324 dbSNP
rs894569747 326 dbSNP
rs1337501849 330 dbSNP
rs1248990250 334 dbSNP
rs754754784 338 dbSNP
rs1180753549 343 dbSNP
rs1453081420 347 dbSNP
rs957787044 349 dbSNP
rs1034477133 351 dbSNP
rs980598690 352 dbSNP
rs1003049182 353 dbSNP
rs907402124 357 dbSNP
rs755318508 360 dbSNP
rs1385023991 364 dbSNP
rs969745759 368 dbSNP
rs185426059 369 dbSNP
rs1005159469 371 dbSNP
rs1410464502 372 dbSNP
rs142755720 373 dbSNP
rs1375845817 377 dbSNP
rs550278332 378 dbSNP
rs1301291563 379 dbSNP
rs886762991 385 dbSNP
rs1360101434 389 dbSNP
rs1178945712 391 dbSNP
rs750710747 405 dbSNP
rs1411808802 411 dbSNP
rs1048551192 426 dbSNP
rs866222640 427 dbSNP
rs931057279 428 dbSNP
rs148506019 437 dbSNP
rs1039480804 439 dbSNP
rs1258659718 449 dbSNP
rs994008229 453 dbSNP
rs1317078671 469 dbSNP
rs1205270679 471 dbSNP
rs943866893 480 dbSNP
rs1290759870 483 dbSNP
rs1327028721 488 dbSNP
rs1267389198 489 dbSNP
rs567852873 493 dbSNP
rs899213878 500 dbSNP
rs1038308082 502 dbSNP
rs1310927831 513 dbSNP
rs1395675565 515 dbSNP
rs1380086528 516 dbSNP
rs1384929588 517 dbSNP
rs1007724344 518 dbSNP
rs889394272 520 dbSNP
rs1052001814 521 dbSNP
rs933528856 523 dbSNP
rs1365026953 532 dbSNP
rs1162015737 533 dbSNP
rs977291936 535 dbSNP
rs967729842 543 dbSNP
rs914555044 546 dbSNP
rs1185232732 547 dbSNP
rs1454509900 549 dbSNP
rs990557926 555 dbSNP
rs958784046 559 dbSNP
rs1365149078 560 dbSNP
rs1034426358 561 dbSNP
rs1002995256 562 dbSNP
rs145144907 565 dbSNP
rs971535267 570 dbSNP
rs1426924016 571 dbSNP
rs1486766020 577 dbSNP
rs1263772698 584 dbSNP
rs551035946 601 dbSNP
rs1244093857 609 dbSNP
rs1360475907 611 dbSNP
rs549310565 611 dbSNP
rs1386454044 613 dbSNP
rs1226712818 614 dbSNP
rs757342210 616 dbSNP
rs1297004079 618 dbSNP
rs763817651 618 dbSNP
rs925050182 623 dbSNP
rs1005103812 624 dbSNP
rs181691268 629 dbSNP
rs1048021907 632 dbSNP
rs1456935138 643 dbSNP
rs995591032 645 dbSNP
rs899533993 648 dbSNP
rs947897103 649 dbSNP
rs1039425758 650 dbSNP
rs917862306 652 dbSNP
rs567159176 658 dbSNP
rs764691034 664 dbSNP
rs1430258681 665 dbSNP
rs1026277074 666 dbSNP
rs753652990 668 dbSNP
rs912383972 670 dbSNP
rs963835071 672 dbSNP
rs1041549786 674 dbSNP
rs1292486305 675 dbSNP
rs7513688 680 dbSNP
rs1008170184 681 dbSNP
rs914482275 682 dbSNP
rs1030478546 688 dbSNP
rs997768569 689 dbSNP
rs1297858152 692 dbSNP
rs1403858170 695 dbSNP
rs1382800750 696 dbSNP
rs1345586854 697 dbSNP
rs1345171409 698 dbSNP
rs990117041 699 dbSNP
rs1301492009 702 dbSNP
rs1369503908 706 dbSNP
rs2235567 707 dbSNP
rs1366566821 708 dbSNP
rs927300654 713 dbSNP
rs112080627 717 dbSNP
rs936350147 717 dbSNP
rs903626854 719 dbSNP
rs1482867095 729 dbSNP
rs1273933423 730 dbSNP
rs1197971020 736 dbSNP
rs981510433 742 dbSNP
rs1255990680 750 dbSNP
rs947778895 753 dbSNP
rs971482982 756 dbSNP
rs562827836 757 dbSNP
rs1267781004 760 dbSNP
rs1015079068 762 dbSNP
rs544693478 766 dbSNP
rs1329090800 767 dbSNP
rs991915396 770 dbSNP
rs1399794500 774 dbSNP
rs1490722265 779 dbSNP
rs1175363018 780 dbSNP
rs1470267720 782 dbSNP
rs530709969 783 dbSNP
rs529365096 784 dbSNP
rs1472289315 785 dbSNP
rs1440840882 786 dbSNP
rs545648420 798 dbSNP
rs952298240 816 dbSNP
rs373828304 825 dbSNP
rs1204650802 833 dbSNP
rs1252980307 835 dbSNP
rs1028316162 836 dbSNP
rs1226092134 841 dbSNP
rs1349313043 843 dbSNP
rs1279843171 859 dbSNP
rs76868995 864 dbSNP
rs1335867100 865 dbSNP
rs1322911766 867 dbSNP
rs1453053437 874 dbSNP
rs899489698 877 dbSNP
rs1318438616 878 dbSNP
rs1400257123 882 dbSNP
rs1408810194 883 dbSNP
rs759916825 886 dbSNP
rs190819687 887 dbSNP
rs1184637551 889 dbSNP
rs1462916234 892 dbSNP
rs1246785744 896 dbSNP
rs1208645784 899 dbSNP
rs1448016412 903 dbSNP
rs1284361375 906 dbSNP
rs145286218 906 dbSNP
rs1346312849 911 dbSNP
rs1353861836 925 dbSNP
rs1313890776 927 dbSNP
rs1246509042 928 dbSNP
rs1030511121 938 dbSNP
rs890877975 939 dbSNP
rs139697740 940 dbSNP
rs1295040978 945 dbSNP
rs997678997 950 dbSNP
rs1320400971 957 dbSNP
rs892763666 957 dbSNP
rs557653037 964 dbSNP
rs1399316861 965 dbSNP
rs1365242126 973 dbSNP
rs1000971088 974 dbSNP
rs147395277 980 dbSNP
rs1388713950 981 dbSNP
rs770661440 984 dbSNP
rs1054759534 986 dbSNP
rs1476040373 995 dbSNP
rs937300146 998 dbSNP
rs879179409 1010 dbSNP
rs1449359487 1012 dbSNP
rs1290656671 1015 dbSNP
rs758525520 1016 dbSNP
rs896207071 1020 dbSNP
rs1481233670 1023 dbSNP
rs1377795281 1028 dbSNP
rs1180884314 1030 dbSNP
rs762556890 1044 dbSNP
rs1035303736 1045 dbSNP
rs927248478 1046 dbSNP
rs981456682 1047 dbSNP
rs1252667723 1052 dbSNP
rs760452989 1063 dbSNP
rs918527679 1065 dbSNP
rs1261344670 1071 dbSNP
rs1038302724 1073 dbSNP
rs1368897196 1075 dbSNP
rs1170229801 1089 dbSNP
rs1410853766 1090 dbSNP
rs1205597313 1094 dbSNP
rs941249600 1095 dbSNP
rs1324560447 1098 dbSNP
rs1479211133 1100 dbSNP
rs561947005 1103 dbSNP
rs1490746692 1108 dbSNP
rs199959602 1118 dbSNP
rs1337895010 1120 dbSNP
rs1308088051 1122 dbSNP
rs1275114615 1129 dbSNP
rs1217410232 1138 dbSNP
rs1322656517 1141 dbSNP
rs953474982 1143 dbSNP
rs1406806080 1145 dbSNP
rs923348770 1147 dbSNP
rs1297803094 1153 dbSNP
rs976273847 1156 dbSNP
rs1404495417 1161 dbSNP
rs574903241 1162 dbSNP
rs907968139 1163 dbSNP
rs1469755399 1168 dbSNP
rs1031561057 1176 dbSNP
rs1176570829 1180 dbSNP
rs983591136 1185 dbSNP
rs1405413294 1196 dbSNP
rs41303863 1202 dbSNP
rs535586026 1221 dbSNP
rs1234409842 1222 dbSNP
rs1201487394 1223 dbSNP
rs1460841691 1224 dbSNP
rs1263649219 1229 dbSNP
rs1225486562 1230 dbSNP
rs1327150728 1242 dbSNP
rs575938387 1245 dbSNP
rs115060437 1246 dbSNP
rs1375735114 1262 dbSNP
rs1301487772 1263 dbSNP
rs1452331964 1263 dbSNP
rs1407529659 1266 dbSNP
rs975387860 1270 dbSNP
rs1470707592 1278 dbSNP
rs1157662884 1281 dbSNP
rs1419327768 1282 dbSNP
rs534412091 1285 dbSNP
rs567034086 1292 dbSNP
rs1178947550 1296 dbSNP
rs1017856174 1300 dbSNP
rs552109636 1301 dbSNP
rs1056128352 1305 dbSNP
rs771325605 1305 dbSNP
rs1260236219 1307 dbSNP
rs1484816939 1307 dbSNP
rs1241141395 1314 dbSNP
rs1318992343 1318 dbSNP
rs1007856070 1320 dbSNP
rs890825907 1327 dbSNP
rs1283905698 1330 dbSNP
rs1203629273 1331 dbSNP
rs897003113 1337 dbSNP
rs1020450796 1343 dbSNP
rs1038568990 1344 dbSNP
rs781184225 1346 dbSNP
rs541643153 1349 dbSNP
rs1346649506 1351 dbSNP
rs533618331 1352 dbSNP
rs114410245 1358 dbSNP
rs1385642581 1376 dbSNP
rs1197064173 1377 dbSNP
rs931953261 1378 dbSNP
rs1454181434 1379 dbSNP
rs1187231767 1381 dbSNP
rs1340538356 1383 dbSNP
rs768443584 1389 dbSNP
rs1316946759 1390 dbSNP
rs905782956 1397 dbSNP
rs1398597939 1401 dbSNP
rs1225651230 1403 dbSNP
rs1045729935 1406 dbSNP
rs562933407 1407 dbSNP
rs41303865 1411 dbSNP
rs983924025 1416 dbSNP
rs924136043 1417 dbSNP
rs1383347075 1425 dbSNP
rs1185339528 1433 dbSNP
rs930773350 1434 dbSNP
rs1165279744 1435 dbSNP
rs1460254023 1440 dbSNP
rs920733115 1452 dbSNP
rs979974827 1454 dbSNP
rs974957632 1462 dbSNP
rs1430164867 1463 dbSNP
rs964897578 1466 dbSNP
rs1019146653 1471 dbSNP
rs1490583963 1472 dbSNP
rs987721723 1473 dbSNP
rs1194490612 1482 dbSNP
rs757428172 1484 dbSNP
rs1191066777 1485 dbSNP
rs1448983119 1486 dbSNP
rs1264147843 1507 dbSNP
rs577219329 1516 dbSNP
rs529422225 1520 dbSNP
rs1230272235 1522 dbSNP
rs968364140 1526 dbSNP
rs1222267539 1529 dbSNP
rs1403759043 1535 dbSNP
rs1357735208 1537 dbSNP
rs754057742 1540 dbSNP
rs1019975292 1547 dbSNP
rs1389525448 1553 dbSNP
rs1023823802 1561 dbSNP
rs1010370226 1562 dbSNP
rs11541292 1565 dbSNP
rs1339222414 1573 dbSNP
rs1298475507 1576 dbSNP
rs373328724 1580 dbSNP
rs960374803 1581 dbSNP
rs1427978441 1584 dbSNP
rs1342041937 1591 dbSNP
rs1033218691 1592 dbSNP
rs777760772 1595 dbSNP
rs1179924855 1606 dbSNP
rs1404175437 1614 dbSNP
rs1001378943 1615 dbSNP
rs1197878186 1616 dbSNP
rs1460399082 1619 dbSNP
rs1263035031 1625 dbSNP
rs139490441 1631 dbSNP
rs1045677890 1635 dbSNP
rs753153513 1636 dbSNP
rs1165169326 1637 dbSNP
rs1405916603 1638 dbSNP
rs768083997 1640 dbSNP
rs1166282114 1647 dbSNP
rs1334754657 1649 dbSNP
rs1329331124 1650 dbSNP
rs1448679678 1653 dbSNP
rs1403881252 1656 dbSNP
rs184929734 1659 dbSNP
rs1005794657 1661 dbSNP
rs1335988721 1664 dbSNP
rs889734624 1675 dbSNP
rs1049662430 1676 dbSNP
rs1356968369 1680 dbSNP
rs192389186 1681 dbSNP
rs1364564359 1682 dbSNP
rs933869077 1682 dbSNP
rs901865169 1683 dbSNP
rs534753565 1684 dbSNP
rs563899190 1686 dbSNP
rs1489905006 1695 dbSNP
rs1556036 1697 dbSNP
rs1280152466 1698 dbSNP
rs766217070 1699 dbSNP
rs943537625 1702 dbSNP
rs1437782588 1709 dbSNP
rs1242127622 1727 dbSNP
rs912084808 1733 dbSNP
rs1314025785 1740 dbSNP
rs752787374 1743 dbSNP
rs1342145697 1747 dbSNP
rs916718585 1748 dbSNP
rs1212328843 1749 dbSNP
rs987667626 1750 dbSNP
rs991050621 1755 dbSNP
rs555585251 1768 dbSNP
rs1385017531 1779 dbSNP
rs150511716 1780 dbSNP
rs1278505034 1782 dbSNP
rs1222536521 1786 dbSNP
rs1343214297 1787 dbSNP
rs966944016 1789 dbSNP
rs912865402 1799 dbSNP
rs1445905985 1802 dbSNP
rs1284603011 1806 dbSNP
rs1218348417 1807 dbSNP
rs369352650 1808 dbSNP
rs1290792004 1813 dbSNP
rs1246390949 1814 dbSNP
rs988496116 1815 dbSNP
rs571547141 1818 dbSNP
rs113167981 1824 dbSNP
rs1327103546 1830 dbSNP
rs762945007 1831 dbSNP
rs1005414904 1836 dbSNP
rs1164654471 1837 dbSNP
rs889638906 1844 dbSNP
rs574506048 1855 dbSNP
rs1167839724 1857 dbSNP
rs998105556 1858 dbSNP
rs969863691 1859 dbSNP
rs1195155458 1860 dbSNP
rs540691933 1863 dbSNP
rs552805056 1867 dbSNP
rs1489740281 1868 dbSNP
rs901056838 1881 dbSNP
rs536939227 1884 dbSNP
rs1323277228 1888 dbSNP
rs1270536499 1905 dbSNP
rs1024173459 1906 dbSNP
rs1175718731 1907 dbSNP
rs1280305146 1908 dbSNP
rs1479595920 1910 dbSNP
rs1221948039 1911 dbSNP
rs141650950 1924 dbSNP
rs567071121 1925 dbSNP
rs1353264665 1932 dbSNP
rs1044210227 1935 dbSNP
rs1469918722 1950 dbSNP
rs1048154259 1954 dbSNP
rs1172317938 1955 dbSNP
rs1479262687 1958 dbSNP
rs558378521 1965 dbSNP
rs1207225648 1968 dbSNP
rs1458557602 1971 dbSNP
rs397979011 1975 dbSNP
rs5772242 1975 dbSNP
rs1202434945 1976 dbSNP
rs899199773 1977 dbSNP
rs1203784086 1992 dbSNP
rs540174699 1995 dbSNP
rs373638506 2001 dbSNP
rs1201943053 2002 dbSNP
rs1323095672 2004 dbSNP
rs56325358 2010 dbSNP
rs912029865 2012 dbSNP
rs1051898158 2013 dbSNP
rs972448275 2015 dbSNP
rs550980953 2019 dbSNP
rs370483139 2020 dbSNP
rs914164283 2030 dbSNP
rs1277498481 2033 dbSNP
rs990175356 2040 dbSNP
rs1016571678 2044 dbSNP
rs1443598449 2045 dbSNP
rs953736657 2046 dbSNP
rs1469675260 2054 dbSNP
rs1028170783 2057 dbSNP
rs1176402184 2062 dbSNP
rs535503763 2066 dbSNP
rs568408260 2067 dbSNP
rs186854970 2073 dbSNP
rs1031992787 2074 dbSNP
rs111407998 2076 dbSNP
rs902528522 2080 dbSNP
rs1460749486 2084 dbSNP
rs1361158437 2086 dbSNP
rs768529747 2088 dbSNP
rs1212557318 2093 dbSNP
rs1315159791 2097 dbSNP
rs1283675067 2098 dbSNP
rs1224765275 2100 dbSNP
rs563988018 2101 dbSNP
rs1177046993 2102 dbSNP
rs1011416036 2108 dbSNP
rs1400547980 2110 dbSNP
rs1406254211 2116 dbSNP
rs746835888 2119 dbSNP
rs1179248900 2121 dbSNP
rs1157739732 2128 dbSNP
rs551945483 2131 dbSNP
rs1382080670 2136 dbSNP
rs1181729585 2137 dbSNP
rs1256631350 2152 dbSNP
rs1485022059 2153 dbSNP
rs939502541 2158 dbSNP
rs41310353 2166 dbSNP
rs563417148 2168 dbSNP
rs1459592184 2170 dbSNP
rs1245932116 2173 dbSNP
rs1322647857 2175 dbSNP
rs542070298 2177 dbSNP
rs1315289786 2179 dbSNP
rs1397348445 2180 dbSNP
rs1359424014 2190 dbSNP
rs940262918 2193 dbSNP
rs1400056097 2194 dbSNP
rs899151528 2198 dbSNP
rs1161551564 2207 dbSNP
rs1423953723 2214 dbSNP
rs909542029 2218 dbSNP
rs1017569643 2222 dbSNP
rs1210403245 2231 dbSNP
rs1463276413 2241 dbSNP
rs1007573517 2242 dbSNP
rs1194708815 2243 dbSNP
rs1489290670 2244 dbSNP
rs574355515 2247 dbSNP
rs1222325828 2254 dbSNP
rs183686037 2260 dbSNP
rs1267824209 2264 dbSNP
rs965218870 2276 dbSNP
rs1307334293 2296 dbSNP
rs1277145704 2310 dbSNP
rs749526976 2313 dbSNP
rs1031478426 2314 dbSNP
rs371392813 2318 dbSNP
rs1300758604 2321 dbSNP
rs11800239 2324 dbSNP
rs1450625628 2327 dbSNP
rs1381406832 2328 dbSNP
rs1303439186 2330 dbSNP
rs201171 2332 dbSNP
rs1295276570 2335 dbSNP
rs192973479 2337 dbSNP
rs1160877174 2340 dbSNP
rs1420663201 2345 dbSNP
rs925580951 2348 dbSNP
rs1171595415 2356 dbSNP
rs1385236159 2357 dbSNP
rs1427211491 2363 dbSNP
rs781773202 2364 dbSNP
rs1446912307 2374 dbSNP
rs1270066441 2375 dbSNP
rs1055120326 2376 dbSNP
rs1003555913 2380 dbSNP
rs1259134019 2392 dbSNP
rs979783024 2398 dbSNP
rs906714122 2406 dbSNP
rs1319557021 2408 dbSNP
rs755583597 2408 dbSNP
rs1231867241 2414 dbSNP
rs1331224278 2416 dbSNP
rs575765242 2425 dbSNP
rs1181898556 2435 dbSNP
rs1331798672 2437 dbSNP
rs1467051176 2439 dbSNP
rs948413324 2442 dbSNP
rs917011944 2445 dbSNP
rs993024329 2446 dbSNP
rs374825131 2447 dbSNP
rs1379475266 2450 dbSNP
rs1180222309 2451 dbSNP
rs1419015081 2455 dbSNP
rs1239096919 2456 dbSNP
rs187930689 2457 dbSNP
rs1460302641 2459 dbSNP
rs1260834333 2461 dbSNP
rs1354143144 2462 dbSNP
rs1199557880 2466 dbSNP
rs1026594510 2468 dbSNP
rs910129903 2469 dbSNP
rs374355213 2470 dbSNP
rs147980438 2471 dbSNP
rs1376059477 2473 dbSNP
rs534832979 2474 dbSNP
rs1448691784 2483 dbSNP
rs1380357199 2485 dbSNP
rs570598819 2486 dbSNP
rs369156912 2487 dbSNP
rs1017516882 2488 dbSNP
rs1313567429 2489 dbSNP
rs1007521262 2500 dbSNP
rs1161019883 2503 dbSNP
rs1443126846 2504 dbSNP
rs1242946723 2509 dbSNP
rs374790577 2511 dbSNP
rs1186333543 2515 dbSNP
rs1442647979 2517 dbSNP
rs368039416 2518 dbSNP
rs1030371809 2521 dbSNP
rs1043868 2522 dbSNP
rs1401052679 2523 dbSNP
rs551984107 2524 dbSNP
rs921044874 2525 dbSNP
rs1242265423 2526 dbSNP
rs976515570 2528 dbSNP
rs145914519 2529 dbSNP
rs1459929148 2532 dbSNP
rs563453725 2541 dbSNP
rs969079230 2544 dbSNP
rs1427372835 2547 dbSNP
rs1361289171 2553 dbSNP
rs1399451270 2553 dbSNP
rs1160927322 2557 dbSNP
rs1421103630 2567 dbSNP
rs1195374934 2571 dbSNP
rs1413443814 2572 dbSNP
rs548189359 2573 dbSNP
rs183827840 2576 dbSNP
rs1219925736 2587 dbSNP
rs936915918 2596 dbSNP
rs1801789 2601 dbSNP
rs375224029 2604 dbSNP
rs1263301423 2607 dbSNP
rs948361841 2608 dbSNP
rs1489840271 2609 dbSNP
rs1305825635 2611 dbSNP
rs867677240 2634 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' gaccucucucucuCCGAGUCa 5'
                       ||||||| 
Target 5' -------------GGCUCAGc 3'
1 - 8
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000377663.3 | 3UTR | CCUGGCUCAGCCUCCCAAAGUGCUGGGAUUACAGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000377663.3 | 3UTR | GGCUCAGCCUCCCAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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