pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RASSF4   
Synonyms AD037
Description Ras association domain family member 4
Transcript NM_032023   
Expression
Putative miRNA Targets on RASSF4
3'UTR of RASSF4
(miRNA target sites are highlighted)
>RASSF4|NM_032023|3'UTR
   1 CTGGCCAACACCTGCCTCTTCCAAAGTCCCCAGCAGTGGCAGGTGTACACTGAGCCCTGGTTGCTGGCCCCGGCCGGTCA
  81 CATTGACTGATGGCCACCGCCTGACGAATCGAGTGCCTGTGTGTCTACCTCTCTGAAGCCTGAGCACCATGATTCCCACA
 161 GCCAGCTCTTGGCTCCAAGATGAGCACCCACAGGAAGCCGACCCAGGCCTGAGGGGCCAGGAACTTGCTGGGTCAGATCT
 241 GTGTGGCCAGCCCTGTCCACACCATGCCTCTCCTGCACTGGAGAGCAGTGCTGGCCCAGCCCCTGCGGCTTAGGCTTCAT
 321 CTGCTTGCACATTGCCTGTCCCAGAGCCCCTGTGGGTCCACAAGCCCCTGTCCTCTTCCTTCATATGAGATTCTTGTCTG
 401 CCCTCATATCACGCTGCCCCACAGGAATGCTGCTGGGAAAAGCAGGGCCTGCCAGCAGGTATGAGATCTAGCCTGCTTTC
 481 AGCCATCACCTTGCCACAGTGTCCCCGGCTTCTAAGCCTCCAATATCACCCTGTGAGCCTCGCACAGCTCAGCCCCAACA
 561 CAGAGGTGAGACCAGGAATAAGGCCACAAGTATCTCACTTTCTCTGCAGAAATCAATCTTTACTTCATCAGAGAGACCTA
 641 AAGCGATTCTTACAAGGAGCTTGCTGCAAGAAACACGGTCATTCAATCACATTGAGGAGGGTCCACATGGCATTGAGAGG
 721 GTGCTGCCCGCTCAATGCCCAGCAGCAGCTCTGGAAGGCAGTGCTCAGCCCCATCACCACTGTCCCGTGGATGCCTGTGT
 801 ACCTCTTGCCTTTTCTGGGCTTGCGTTTCTCTCCTCTAGTGGGTGGGGATGACTTTCAATGACTTTCAATACTTCCCCTG
 881 AAGGAAGAATGATAAGGAGAAATGTCTGTTTTGAGGAAAGGGCTTTGAATTCCCCAGATACTGAACAATTTGTGTTTGTG
 961 ACTGATGGAGAATTTCAGGAATGAATGAGAAAGCCTTTGCGAAACTATGCAACAGTTTACATCAGTCATGTGAAGTATTT
1041 GTCTAAAACAGAGCAAACTGAAGACCAAATTATTCTCCTGTTGAGGTCCGTGGATGGCAGATTTAAAGGGAAGAACCACA
1121 AAGGCTTGCAAAGATAGGAGAGGCTCCATCTCTAATGCATGTAGAAGCTCCTTACGGGTGCCCATCAAGAGCATAGCTTG
1201 GAAGCCACCATGCTGTGCGGAACTGCGTCAGGGCAAATGTCACAGCAGGATTTCCCCAACCCAGCTCCATCATCACAGAC
1281 ACAGAGAGCTGCAGGGGAGGCCTGCCCACTGTTTTGTCGACTCTGCCCTCCTCTGGCAGCATAGATCCTTAGGTGCTCAA
1361 TAAAGGTGTGCTGTATTGAACTGAAGAAGTGAGAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucgacaAGGACGACUu 5'
                |||||:||| 
Target 5' ttattcTCCTGTTGAg 3'
1070 - 1085 134.00 -12.60
2
miRNA  3' ucgacaAGGACGACUu 5'
                | ||||||: 
Target 5' caggaaTGCTGCTGGg 3'
422 - 437 126.00 -10.30
3
miRNA  3' ucGACAAGGACGACUu 5'
            || | :|||| || 
Target 5' caCTTTCTCTGCAGAa 3'
596 - 611 118.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN18735263 5 COSMIC
COSN510338 6 COSMIC
COSN31561136 40 COSMIC
COSN30149171 76 COSMIC
COSN30535408 77 COSMIC
COSN31539863 118 COSMIC
COSN28667468 167 COSMIC
COSN9209234 217 COSMIC
COSN2515208 277 COSMIC
COSN20939270 347 COSMIC
COSN23187942 617 COSMIC
COSN25038496 826 COSMIC
COSN31536329 1091 COSMIC
COSN15594824 1327 COSMIC
COSN27246394 1418 COSMIC
COSN27529737 1418 COSMIC
COSN26265691 1484 COSMIC
COSN9209235 1952 COSMIC
COSN19533733 2057 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1352746233 3 dbSNP
rs768257682 4 dbSNP
rs776489250 5 dbSNP
rs761804932 9 dbSNP
rs764941651 10 dbSNP
rs772997934 11 dbSNP
rs763182390 14 dbSNP
rs1390527719 16 dbSNP
rs1410362786 18 dbSNP
rs766631786 26 dbSNP
rs1309792886 28 dbSNP
rs1376922938 29 dbSNP
rs751762059 31 dbSNP
rs755113334 33 dbSNP
rs1361117299 36 dbSNP
rs1176739185 44 dbSNP
rs1039507973 45 dbSNP
rs994781693 46 dbSNP
rs1487419261 49 dbSNP
rs767634417 51 dbSNP
rs1369797099 52 dbSNP
rs1395918757 58 dbSNP
rs1187939984 63 dbSNP
rs1468648012 69 dbSNP
rs543762843 70 dbSNP
rs1232854165 72 dbSNP
rs561684738 73 dbSNP
rs1292569728 74 dbSNP
rs529095691 76 dbSNP
rs994222031 77 dbSNP
rs187068372 78 dbSNP
rs1023766457 80 dbSNP
rs565817186 84 dbSNP
rs1352836172 88 dbSNP
rs985361154 91 dbSNP
rs1278403342 98 dbSNP
rs1291997810 99 dbSNP
rs112959729 100 dbSNP
rs1352187699 104 dbSNP
rs376117285 106 dbSNP
rs982158453 107 dbSNP
rs965154944 111 dbSNP
rs760271462 112 dbSNP
rs976583538 125 dbSNP
rs1407384228 138 dbSNP
rs1031022388 142 dbSNP
rs550994318 146 dbSNP
rs1179596813 153 dbSNP
rs913299271 158 dbSNP
rs1187746135 160 dbSNP
rs1486188750 161 dbSNP
rs946191106 166 dbSNP
rs3814569 167 dbSNP
rs1314712128 174 dbSNP
rs915470057 182 dbSNP
rs776376417 187 dbSNP
rs1331214958 189 dbSNP
rs537319329 192 dbSNP
rs1413985541 200 dbSNP
rs368587655 201 dbSNP
rs1415230491 203 dbSNP
rs1056029251 211 dbSNP
rs896086172 223 dbSNP
rs1347699655 224 dbSNP
rs1160005532 226 dbSNP
rs912024967 231 dbSNP
rs1416395688 242 dbSNP
rs1466885201 247 dbSNP
rs1164791692 252 dbSNP
rs1475797016 261 dbSNP
rs371716431 263 dbSNP
rs1014419596 264 dbSNP
rs1185083510 267 dbSNP
rs567713008 271 dbSNP
rs765070540 277 dbSNP
rs1241144838 290 dbSNP
rs1208862487 298 dbSNP
rs867033364 301 dbSNP
rs1465836775 302 dbSNP
rs897521384 303 dbSNP
rs535261137 304 dbSNP
rs772786738 307 dbSNP
rs553188990 308 dbSNP
rs1379806866 312 dbSNP
rs993966855 328 dbSNP
rs746680505 331 dbSNP
rs189940299 333 dbSNP
rs1289640066 339 dbSNP
rs1012797614 344 dbSNP
rs545534078 346 dbSNP
rs1325247719 352 dbSNP
rs1199475563 362 dbSNP
rs1462437313 368 dbSNP
rs1161303683 376 dbSNP
rs1257723612 384 dbSNP
rs752743504 392 dbSNP
rs1370636186 397 dbSNP
rs1456708065 398 dbSNP
rs1168851189 403 dbSNP
rs952374546 404 dbSNP
rs907007720 406 dbSNP
rs1190133754 407 dbSNP
rs557365319 410 dbSNP
rs76732694 413 dbSNP
rs965287873 414 dbSNP
rs976550875 419 dbSNP
rs1180725971 428 dbSNP
rs1020106505 437 dbSNP
rs1267128321 442 dbSNP
rs11239305 448 dbSNP
rs1306670103 459 dbSNP
rs1298007057 462 dbSNP
rs1230916506 466 dbSNP
rs750495897 467 dbSNP
rs1302770920 468 dbSNP
rs1170930433 473 dbSNP
rs1393579835 477 dbSNP
rs182890685 486 dbSNP
rs1461886040 497 dbSNP
rs1463801424 504 dbSNP
rs1335950899 505 dbSNP
rs7085359 507 dbSNP
rs187348131 508 dbSNP
rs1282394299 510 dbSNP
rs144084628 511 dbSNP
rs912078384 524 dbSNP
rs1269421892 529 dbSNP
rs1175441161 530 dbSNP
rs1277802415 538 dbSNP
rs1480239880 542 dbSNP
rs1275105195 543 dbSNP
rs7068974 552 dbSNP
rs950320441 557 dbSNP
rs1279855628 558 dbSNP
rs918995576 561 dbSNP
rs1332941496 567 dbSNP
rs930367619 569 dbSNP
rs1279815545 573 dbSNP
rs1036525888 581 dbSNP
rs1442311484 583 dbSNP
rs1208604458 590 dbSNP
rs1391339118 599 dbSNP
rs1266042737 604 dbSNP
rs551080277 606 dbSNP
rs930810235 608 dbSNP
rs1433237556 610 dbSNP
rs1478512768 611 dbSNP
rs1193755476 619 dbSNP
rs34407917 637 dbSNP
rs569261951 640 dbSNP
rs915545073 645 dbSNP
rs879318703 646 dbSNP
rs888220552 655 dbSNP
rs1156242405 660 dbSNP
rs17418904 677 dbSNP
rs139302662 678 dbSNP
rs150022723 681 dbSNP
rs145151016 687 dbSNP
rs1201270215 691 dbSNP
rs547204993 693 dbSNP
rs1259046319 697 dbSNP
rs1238422741 699 dbSNP
rs1330501743 700 dbSNP
rs1020158953 701 dbSNP
rs1413361313 702 dbSNP
rs1010956516 705 dbSNP
rs1022728467 708 dbSNP
rs953379761 709 dbSNP
rs1007787394 711 dbSNP
rs1019144428 714 dbSNP
rs571770905 721 dbSNP
rs1297678181 729 dbSNP
rs775515275 730 dbSNP
rs1161325060 731 dbSNP
rs1235741210 736 dbSNP
rs1033087275 739 dbSNP
rs74755186 743 dbSNP
rs772476921 748 dbSNP
rs1259902404 755 dbSNP
rs917290512 761 dbSNP
rs1270044794 764 dbSNP
rs950041003 770 dbSNP
rs1232021861 771 dbSNP
rs1334701518 775 dbSNP
rs557501850 780 dbSNP
rs984528524 781 dbSNP
rs1341954504 784 dbSNP
rs1315760552 787 dbSNP
rs868795383 788 dbSNP
rs1388762445 793 dbSNP
rs1321905427 795 dbSNP
rs1459815500 798 dbSNP
rs1217899537 799 dbSNP
rs193291256 803 dbSNP
rs1163687499 809 dbSNP
rs1049718565 817 dbSNP
rs1473645375 818 dbSNP
rs75668658 821 dbSNP
rs942485706 824 dbSNP
rs1039434941 825 dbSNP
rs900805089 826 dbSNP
rs1249993083 831 dbSNP
rs1211823446 835 dbSNP
rs928533824 842 dbSNP
rs1291200577 847 dbSNP
rs1212056374 849 dbSNP
rs1337892355 852 dbSNP
rs746561851 854 dbSNP
rs1227232552 860 dbSNP
rs1365390741 867 dbSNP
rs770543831 870 dbSNP
rs35938944 875 dbSNP
rs1200520032 877 dbSNP
rs776319137 878 dbSNP
rs1246985552 881 dbSNP
rs1477573155 888 dbSNP
rs1171530779 906 dbSNP
rs1349280987 908 dbSNP
rs1020131290 916 dbSNP
rs1406975257 917 dbSNP
rs1394091552 925 dbSNP
rs903129805 942 dbSNP
rs1430647951 943 dbSNP
rs1000016528 947 dbSNP
rs1033299775 950 dbSNP
rs759318969 963 dbSNP
rs1012972868 964 dbSNP
rs1158087242 977 dbSNP
rs1382845041 984 dbSNP
rs1230712673 987 dbSNP
rs530969507 995 dbSNP
rs1289588890 1000 dbSNP
rs536694428 1001 dbSNP
rs555353708 1002 dbSNP
rs971365146 1008 dbSNP
rs889143374 1009 dbSNP
rs1434686733 1021 dbSNP
rs183814045 1026 dbSNP
rs1311942644 1027 dbSNP
rs769660577 1028 dbSNP
rs972088162 1029 dbSNP
rs1276312237 1037 dbSNP
rs543041861 1041 dbSNP
rs1240017477 1052 dbSNP
rs919499362 1053 dbSNP
rs1438537172 1054 dbSNP
rs1333839421 1059 dbSNP
rs765013885 1063 dbSNP
rs1007509610 1065 dbSNP
rs952436407 1069 dbSNP
rs984968515 1072 dbSNP
rs187991263 1081 dbSNP
rs943541096 1090 dbSNP
rs775163604 1091 dbSNP
rs1414074132 1108 dbSNP
rs762902494 1119 dbSNP
rs559469093 1125 dbSNP
rs1174324063 1128 dbSNP
rs1469115541 1132 dbSNP
rs1251713274 1134 dbSNP
rs1183420336 1135 dbSNP
rs763972768 1141 dbSNP
rs1255805632 1143 dbSNP
rs1450700262 1149 dbSNP
rs1311186994 1153 dbSNP
rs1278715925 1158 dbSNP
rs1026912285 1160 dbSNP
rs1348522957 1173 dbSNP
rs192415138 1175 dbSNP
rs1410250214 1177 dbSNP
rs1352131604 1181 dbSNP
rs750503743 1181 dbSNP
rs747525102 1185 dbSNP
rs544661656 1187 dbSNP
rs1359962828 1189 dbSNP
rs1336311933 1190 dbSNP
rs1440129306 1191 dbSNP
rs1399004760 1192 dbSNP
rs563083498 1193 dbSNP
rs952223387 1195 dbSNP
rs1160600004 1197 dbSNP
rs184321492 1212 dbSNP
rs903099712 1219 dbSNP
rs548991598 1220 dbSNP
rs1181568570 1227 dbSNP
rs1482761281 1233 dbSNP
rs1237681943 1240 dbSNP
rs1000557444 1241 dbSNP
rs1054387019 1247 dbSNP
rs1390221675 1253 dbSNP
rs1460098951 1270 dbSNP
rs112638294 1275 dbSNP
rs894275696 1283 dbSNP
rs1012775110 1284 dbSNP
rs1024367784 1285 dbSNP
rs971494492 1287 dbSNP
rs1227520825 1294 dbSNP
rs1378080424 1305 dbSNP
rs1446587347 1317 dbSNP
rs1305488864 1319 dbSNP
rs147963053 1320 dbSNP
rs1026766328 1322 dbSNP
rs914411916 1324 dbSNP
rs952085923 1337 dbSNP
rs528754850 1342 dbSNP
rs1392911009 1350 dbSNP
rs1164584251 1355 dbSNP
rs947225370 1357 dbSNP
rs1044235068 1366 dbSNP
rs1183267585 1367 dbSNP
rs1447233345 1378 dbSNP
rs530547014 1391 dbSNP
rs985407299 1394 dbSNP
rs1246281802 1396 dbSNP
rs147034743 1402 dbSNP
rs574674915 1402 dbSNP
rs943419955 1402 dbSNP
rs1314553438 1403 dbSNP
rs201773641 1404 dbSNP
rs1355163678 1405 dbSNP
rs76238757 1417 dbSNP
rs901823619 1419 dbSNP
rs1298502657 1420 dbSNP
rs1259649345 1424 dbSNP
rs1458039044 1426 dbSNP
rs1197781354 1428 dbSNP
rs1248251796 1429 dbSNP
rs1352007317 1429 dbSNP
rs1425507456 1430 dbSNP
rs994175023 1432 dbSNP
rs1427499046 1433 dbSNP
rs550643819 1439 dbSNP
rs1188283519 1445 dbSNP
rs571830867 1446 dbSNP
rs1474293950 1447 dbSNP
rs552406306 1450 dbSNP
rs910821263 1463 dbSNP
rs1488735740 1465 dbSNP
rs1465370901 1471 dbSNP
rs887972689 1475 dbSNP
rs141893525 1483 dbSNP
rs1341788546 1484 dbSNP
rs1275591806 1486 dbSNP
rs1006386498 1489 dbSNP
rs551094819 1506 dbSNP
rs1310547609 1507 dbSNP
rs1208867172 1509 dbSNP
rs570402978 1510 dbSNP
rs1397159261 1511 dbSNP
rs569404692 1513 dbSNP
rs976253010 1516 dbSNP
rs539373901 1527 dbSNP
rs766696601 1528 dbSNP
rs1369601603 1529 dbSNP
rs1230990286 1533 dbSNP
rs1431197688 1534 dbSNP
rs1279622264 1535 dbSNP
rs1041376760 1537 dbSNP
rs1253763495 1540 dbSNP
rs955670780 1547 dbSNP
rs924239278 1555 dbSNP
rs935684113 1558 dbSNP
rs536635312 1559 dbSNP
rs754181326 1571 dbSNP
rs1484134508 1577 dbSNP
rs1207589383 1598 dbSNP
rs1200939656 1600 dbSNP
rs894409987 1601 dbSNP
rs1314515611 1603 dbSNP
rs755263480 1606 dbSNP
rs72780685 1607 dbSNP
rs1195941908 1611 dbSNP
rs766690137 1614 dbSNP
rs1392773314 1615 dbSNP
rs1399608419 1615 dbSNP
rs1424531091 1618 dbSNP
rs1301818061 1620 dbSNP
rs943472217 1621 dbSNP
rs1431410633 1642 dbSNP
rs1156898719 1645 dbSNP
rs1045631976 1651 dbSNP
rs1472196800 1657 dbSNP
rs907277666 1659 dbSNP
rs573176279 1660 dbSNP
rs1255705743 1676 dbSNP
rs1379705871 1678 dbSNP
rs1026399545 1683 dbSNP
rs1266261031 1688 dbSNP
rs1208660527 1689 dbSNP
rs887750115 1690 dbSNP
rs929311651 1697 dbSNP
rs1290675731 1700 dbSNP
rs148152657 1703 dbSNP
rs188717299 1704 dbSNP
rs1311533939 1707 dbSNP
rs1374249346 1710 dbSNP
rs1412313847 1711 dbSNP
rs1006849325 1712 dbSNP
rs1456644962 1718 dbSNP
rs1299517957 1721 dbSNP
rs1160134034 1733 dbSNP
rs964957683 1741 dbSNP
rs191629350 1746 dbSNP
rs748491945 1754 dbSNP
rs1340701518 1756 dbSNP
rs544849659 1759 dbSNP
rs1188532006 1775 dbSNP
rs906007061 1780 dbSNP
rs1030492712 1799 dbSNP
rs1293055071 1805 dbSNP
rs1313725718 1817 dbSNP
rs966860308 1819 dbSNP
rs1002644896 1820 dbSNP
rs1233789398 1839 dbSNP
rs140751173 1844 dbSNP
rs924404263 1849 dbSNP
rs749028700 1870 dbSNP
rs758907571 1871 dbSNP
rs935637367 1874 dbSNP
rs989861765 1877 dbSNP
rs1218825234 1880 dbSNP
rs1294853676 1889 dbSNP
rs915827284 1891 dbSNP
rs1009900882 1899 dbSNP
rs778189050 1902 dbSNP
rs1320241952 1904 dbSNP
rs1403486328 1911 dbSNP
rs1389761213 1925 dbSNP
rs968674720 1931 dbSNP
rs985754330 1939 dbSNP
rs911072261 1945 dbSNP
rs965166019 1946 dbSNP
rs976167922 1952 dbSNP
rs150116051 1954 dbSNP
rs1197402869 1959 dbSNP
rs923350829 1962 dbSNP
rs1268500598 1965 dbSNP
rs1211997877 1972 dbSNP
rs1175809862 1978 dbSNP
rs377243220 1983 dbSNP
rs929342022 1985 dbSNP
rs746504869 1986 dbSNP
rs1227158676 1988 dbSNP
rs1422091247 1990 dbSNP
rs770492453 1991 dbSNP
rs1434214255 1995 dbSNP
rs755108766 2005 dbSNP
rs1330442860 2006 dbSNP
rs909175726 2008 dbSNP
rs1406524735 2009 dbSNP
rs138508987 2017 dbSNP
rs1286750848 2019 dbSNP
rs111296356 2046 dbSNP
rs1048244253 2049 dbSNP
rs1250728634 2050 dbSNP
rs1387079881 2051 dbSNP
rs887895222 2052 dbSNP
rs116263359 2054 dbSNP
rs184714638 2060 dbSNP
rs1202092923 2066 dbSNP
rs1242191989 2069 dbSNP
rs1286716748 2077 dbSNP
rs1482296554 2105 dbSNP
rs1251483249 2117 dbSNP
rs189037141 2118 dbSNP
rs1316402675 2119 dbSNP
rs1274581115 2122 dbSNP
rs900756036 2123 dbSNP
rs997690962 2125 dbSNP
rs1275343338 2126 dbSNP
rs1267389601 2132 dbSNP
rs1488940222 2133 dbSNP
rs1193350025 2142 dbSNP
rs566738428 2147 dbSNP
rs73283451 2156 dbSNP
rs1356489719 2159 dbSNP
rs978297734 2163 dbSNP
rs1031825036 2178 dbSNP
rs1413946499 2179 dbSNP
rs1425911779 2180 dbSNP
rs146190662 2183 dbSNP
rs769356717 2187 dbSNP
rs1471862955 2196 dbSNP
rs73283455 2202 dbSNP
rs1183343040 2203 dbSNP
rs535670031 2214 dbSNP
rs1234231393 2226 dbSNP
rs965218504 2228 dbSNP
rs948369603 2230 dbSNP
rs976554050 2230 dbSNP
rs555630570 2231 dbSNP
rs1324852364 2235 dbSNP
rs115590659 2249 dbSNP
rs566816327 2250 dbSNP
rs533976737 2254 dbSNP
rs942010257 2255 dbSNP
rs1282675042 2256 dbSNP
rs1372537344 2260 dbSNP
rs1359827115 2261 dbSNP
rs142705673 2266 dbSNP
rs1456175999 2275 dbSNP
rs768616252 2286 dbSNP
rs144038389 2287 dbSNP
rs1160430156 2294 dbSNP
rs1039104914 2296 dbSNP
rs927525879 2301 dbSNP
rs1322445191 2310 dbSNP
rs1412030221 2318 dbSNP
rs1179780958 2322 dbSNP
rs1472229096 2332 dbSNP
rs938874665 2336 dbSNP
rs1213273949 2340 dbSNP
rs1271567640 2341 dbSNP
rs182496269 2342 dbSNP
rs1057331117 2346 dbSNP
rs1199668575 2348 dbSNP
rs1463533548 2348 dbSNP
rs900473951 2354 dbSNP
rs1216359618 2359 dbSNP
rs1287396300 2362 dbSNP
rs760834590 2362 dbSNP
rs1227963827 2368 dbSNP
rs997491809 2375 dbSNP
rs1232751296 2382 dbSNP
rs1469073295 2385 dbSNP
rs556702877 2396 dbSNP
rs1415294863 2402 dbSNP
rs148665900 2404 dbSNP
rs1321846993 2409 dbSNP
rs1000084765 2419 dbSNP
rs78591816 2436 dbSNP
rs1348517841 2440 dbSNP
rs958455159 2445 dbSNP
rs1432651659 2448 dbSNP
rs1164988090 2457 dbSNP
rs1447101021 2460 dbSNP
rs766502515 2464 dbSNP
rs753986768 2465 dbSNP
rs1486767466 2466 dbSNP
rs1331811207 2470 dbSNP
rs969682023 2471 dbSNP
rs1353810494 2474 dbSNP
rs1360496261 2475 dbSNP
rs775744904 2475 dbSNP
rs1294177311 2476 dbSNP
rs6593453 2482 dbSNP
rs1296319165 2486 dbSNP
rs557423895 2489 dbSNP
rs1304560810 2498 dbSNP
rs577172348 2504 dbSNP
rs928522866 2511 dbSNP
rs950705219 2518 dbSNP
rs1293370572 2526 dbSNP
rs983683607 2542 dbSNP
rs77718303 2543 dbSNP
rs941862982 2544 dbSNP
rs1039072244 2549 dbSNP
rs922033956 2550 dbSNP
rs1422945444 2555 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000374417.2 | 3UTR | AGACAGCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000374417.2 | 3UTR | AGACAGCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUCUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000374417.2 | 3UTR | GAGACAGCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000374417.2 | 3UTR | AGACAGCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000374417.2 | 3UTR | AGCAGUGCUCCCUGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000374417.2 | 3UTR | GAGACAGCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUCUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000374417.2 | 3UTR | AGACAGCGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000374417.2 | 3UTR | AGACAGCGUGUGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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