pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CMBL   
Synonyms JS-1
Description carboxymethylenebutenolidase homolog
Transcript NM_138809   
Expression
Putative miRNA Targets on CMBL
3'UTR of CMBL
(miRNA target sites are highlighted)
>CMBL|NM_138809|3'UTR
   1 CAAGAATCAAGGGCAAGCCTTCCTAGAATAGCTTTCATCCCAAAATTTGCTTGGAAATAGTTAGATCATTTGATTTAATT
  81 TTCACTTTTATAAAATAAGTGTAGGAATCCTAAAATTGATTATTTCATTTGAAACACAAATTCAGTAGGACGTAATGCAT
 161 GAAATAATTTAATTTTTGACATGTACATCGAATCATAATTTAAAAACAAGGTCTGACCAGGTGTAGTGCCTCATGCCTGT
 241 AATTCCAGCACTTTGGGAGGCCAAAGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAG
 321 ACCCCATCTCTACAAAAAATACAAAAATTAGCCTGGTGTGGTGGTGCACGCCTGTAGTCCCAGCTACTTGGGAGGCTGAG
 401 GCACAAGAATCAATAGAACCCAGGAGGTGGAGACTGCAGTGAGCCAAGATTGTGCCACTACTGTACTCTAGCCTGGGCAG
 481 CAGAGTGAGACCCTGTCTCAAAAATAAATAAGTAAATAAATAAATAAATAAAATAAAAACCAGGTCAGTACCTGGAGAAT
 561 TTGAATGATAGAGAATGATAGAGTAATACCCTAATTATTAGTTAAAACCTACAGGCCGGGTGCGGTGGCTCACGCCTGTA
 641 ATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAA
 721 CCCCATCTCTACTAAAAATATAAAAATCAGCCGGGCATGGTGGCATGTGCCTGTAATCCCAGCTACTCAGGAGTCTGAGG
 801 AGGAGAATCACTTGAACCTGGAGGCAGAGGTTGCAGTGAGTCGAGGTTGCGCTACTGCACTCCAGCCTGGACAACAGAGG
 881 GAGACTCTGTCTCAAAAAAAAAAAAAAACCTACAGCTGTTCAAGGACCAGCTGACAGGTCAAGTGTGGCCTTTTCTGGTC
 961 TTTGAACACATCATAGAAAGTGACAAATGCTGCAAAGCCATGAAGAACATGAACTATAAACGGGTAGACTAACTGCCCAG
1041 CTTAGACACTTATCTATGCCACAAAACAGCTGAATTTGTCACATTTATATATTGCAATATGGGAAGTATTGAGATCAAAA
1121 CAGGATTCCATTGACCTAATTATATTAAGCTAATAAACTAATTTTTTGAATTTTTGAATTTGCAGCTTTTTTAAAAAGAT
1201 AGCAGAGAACGGTGGGCTAGAGTTGTCACCCAGCTGTTGTCTCCTAAGCAGTGGATTTCCAAGCACTGGCATTTTTGGGT
1281 CCCAGGGCCTGAGGCTACCTCAGAAATATCTCCTGTGTTTCTGGTGGTGGCGTAAAGGGGAGAGCCGGTGAGAAACTCTG
1361 CACCTGCACCTACGGGGTGCGTACATGTGACTTTGGGCAAGTGACTTGATGTTGTAGTTTTTTTCCTAATTTTGTCTTGA
1441 CGTCCTTCTCAGGAGAGAGTGGCTGTAAACTCTAGCCCTGCCCTGACGGGGATCCTGGGGATGTGGTCGTGGGTGTTTCC
1521 CATGTGCCTTTCATGGGATCCTTCTTTGACCTCACAGACGGCCTGATTCCTGAGTGTCCAACCTGTGGCCAGGTGTCCCT
1601 CTCGCAGGAAGCTTGTTTATCCTGGCACATGACCTTGTGGCTCTCATCTGACCTGTGTCCAGTTTATTCCTACTGAGACA
1681 GCCACTCTCCCGGAGAGCCCTGACCGGGAAAGAAGTTAGGATGGGGTAGAGGAGGCAACTCATCAGAACCCAAGAAATGA
1761 CAGAAGCAGTTTATTGCTTACAGATCCAGAGAACAGAGGGCAGCACGCTTCACAGGGCCAGCAAAAAGGGGGAGCCATTC
1841 AGGACACATGGGCTCAACCAGAAGGTGGAGAACGAGAGAGAGAGGGAGCTATGAGCCAAAGCCTTCACTGGGGCCCAGGG
1921 TGTCATCTATGCAGGTTTCCCCTGGAGGTTCTAACTGGGGGGTTTAGAGCAAGCAGGCATGAGCCCCGGGGACTCACGCT
2001 GTGACTGAGAGGGGTCGGTGTGGGTAGGATATCGGCATGGTCCATGTGGGTGTGGGGGTCAGTGGGACAAGTCAAGCAGG
2081 TGGTATCCAGCTGTCCATGGGAAGGTGGTCCCAGGAGGCGGTTTTGTAAGGCAGATGTCTGGATCGACCACCTTGGGGAA
2161 CAGTGAGAAGTTGTATAACTGGAAACTGTGTTACTAATCCCTGCTTCTAGTATGAGAAAGTCCAACTTACATTCAAATAG
2241 ATGCTCAGGAAACATAAAATTCAAAGAATTCCCAAACTTGAGCTTCCTGAGCCTCAGTTTTTGCATCTGTCAAATGGGTA
2321 TGGGGAGACCCTTTGCCTAATGTTGAGAGAATCCAAGCCTGAGCAGGGCTGGTCTACTGTGGACACTTAGTTGTGGACCC
2401 CAACAGGCCAAAGCCCTTGCCTGCTGAGGGCTGCTCCCAGGAGGCCTCACACATTCATCCGGCCTCCCAGGAAACCCCTG
2481 AGATGTGCTGGGCTTTTGCCGTGGAACGGTGTCGGTGAGCATGTGGCCAGTAGCCAGAGTCTTCAACATAGGTGGGAGGT
2561 CTGAAATTCGTGCGAGAATGAACCAAGGGTGTGGCTGTATCCTTCATGGTGAGCTTGGGGCCTGGGCAGCCTTCCCTCTG
2641 CTGAGTCCTTTGGTCAAATGTCATGGTGTTCTGAACCAGCACTGCAGATAGAAGTATAATGTAAGTCACACACGTACTTC
2721 TTTAAAAAGATATGTTCTTCAGTGACTATTAGACAAACAGATAAATGAAGGTAAAGGGAAAAAATGGCAACTTTAGCTTT
2801 TTTCCCCATGTATGTAATTTTAAATTTTCTTATAGCCCCATTAAAAAAAGGAAAGAGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCCG--UCCAAGGACCUAGUa 5'
            ||||  ||||   ||||||| 
Target 5' ggAGGCCGAGGTGGGTGGATCAc 3'
655 - 677 161.00 -20.90
2
miRNA  3' ucUCCGUCCAAGGACCUAGUa 5'
            |||||| | :|||||||: 
Target 5' taAGGCAGATGTCTGGATCGa 3'
2127 - 2147 159.00 -23.60
3
miRNA  3' ucUCCG--UCCAAGGACCUAGUa 5'
            ||||  | ||   ||||||| 
Target 5' ggAGGCCAAAGTGGGTGGATCAc 3'
256 - 278 153.00 -15.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30498410 10 COSMIC
COSN31828477 15 COSMIC
COSN31561045 27 COSMIC
COSN30510824 45 COSMIC
COSN28851096 58 COSMIC
COSN30131067 59 COSMIC
COSN19141040 99 COSMIC
COSN20075267 105 COSMIC
COSN30494971 121 COSMIC
COSN30193026 130 COSMIC
COSN31571154 153 COSMIC
COSN1304101 186 COSMIC
COSN1304100 244 COSMIC
COSN28607804 643 COSMIC
COSN2055644 685 COSMIC
COSN20100989 894 COSMIC
COSN32186443 1111 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs755769157 6 dbSNP
rs1257474648 7 dbSNP
rs569668328 15 dbSNP
rs1445683686 22 dbSNP
rs190987855 24 dbSNP
rs368492170 25 dbSNP
rs1224605748 26 dbSNP
rs1256102590 28 dbSNP
rs1327266123 29 dbSNP
rs746211990 29 dbSNP
rs759387749 30 dbSNP
rs1485933215 31 dbSNP
rs774382743 36 dbSNP
rs1206499447 37 dbSNP
rs1328066625 40 dbSNP
rs766250214 41 dbSNP
rs369632245 42 dbSNP
rs1384981511 55 dbSNP
rs779980363 57 dbSNP
rs959083153 67 dbSNP
rs758332620 70 dbSNP
rs995134552 72 dbSNP
rs1451126236 74 dbSNP
rs1363060683 85 dbSNP
rs1176934169 91 dbSNP
rs529757867 92 dbSNP
rs116704059 101 dbSNP
rs1004491389 118 dbSNP
rs1443035697 119 dbSNP
rs115081846 126 dbSNP
rs372248081 129 dbSNP
rs1432673076 136 dbSNP
rs1262465089 142 dbSNP
rs578137648 151 dbSNP
rs756166953 152 dbSNP
rs368914544 157 dbSNP
rs900571138 158 dbSNP
rs1308541620 168 dbSNP
rs752755112 171 dbSNP
rs140540093 173 dbSNP
rs1199675071 180 dbSNP
rs1296749449 187 dbSNP
rs113659583 189 dbSNP
rs1036166253 191 dbSNP
rs1002915651 193 dbSNP
rs1476908894 199 dbSNP
rs1169370090 202 dbSNP
rs576067233 210 dbSNP
rs1409258646 211 dbSNP
rs1168059687 216 dbSNP
rs567735151 220 dbSNP
rs978350226 221 dbSNP
rs1426832550 229 dbSNP
rs1023175589 230 dbSNP
rs1330944823 232 dbSNP
rs1326536577 240 dbSNP
rs1006403987 244 dbSNP
rs1363311577 254 dbSNP
rs918106864 260 dbSNP
rs1297035034 263 dbSNP
rs1380208350 265 dbSNP
rs992305867 269 dbSNP
rs887958875 273 dbSNP
rs1290590137 279 dbSNP
rs556478622 285 dbSNP
rs1449447422 288 dbSNP
rs1195094688 293 dbSNP
rs1383784285 294 dbSNP
rs1337213206 295 dbSNP
rs959115765 297 dbSNP
rs1047921390 309 dbSNP
rs1033397152 312 dbSNP
rs1163611409 316 dbSNP
rs929444635 320 dbSNP
rs896939575 322 dbSNP
rs2578609 326 dbSNP
rs1041183086 328 dbSNP
rs943691178 334 dbSNP
rs1373772477 342 dbSNP
rs1475298216 345 dbSNP
rs1195382011 349 dbSNP
rs542758884 350 dbSNP
rs1247629551 352 dbSNP
rs1296024952 354 dbSNP
rs985395098 356 dbSNP
rs1385535360 358 dbSNP
rs1004118382 369 dbSNP
rs11540020 370 dbSNP
rs1462940391 377 dbSNP
rs554089265 385 dbSNP
rs1203610555 388 dbSNP
rs751840169 396 dbSNP
rs1340637688 398 dbSNP
rs1206809872 402 dbSNP
rs1244908034 407 dbSNP
rs1252622483 411 dbSNP
rs956064249 413 dbSNP
rs1367919411 416 dbSNP
rs1035814529 420 dbSNP
rs1471963091 427 dbSNP
rs900602108 429 dbSNP
rs1409265055 430 dbSNP
rs1224593374 434 dbSNP
rs528200416 451 dbSNP
rs1318870505 466 dbSNP
rs1039093397 471 dbSNP
rs1453941133 478 dbSNP
rs936699169 478 dbSNP
rs1338158273 481 dbSNP
rs1315314073 485 dbSNP
rs903841263 491 dbSNP
rs981458827 492 dbSNP
rs1226350446 508 dbSNP
rs970049479 509 dbSNP
rs945668588 512 dbSNP
rs1454208954 516 dbSNP
rs753992372 533 dbSNP
rs926396982 533 dbSNP
rs938150490 533 dbSNP
rs1380333029 541 dbSNP
rs766727826 548 dbSNP
rs1364601058 550 dbSNP
rs1472362255 552 dbSNP
rs371676105 552 dbSNP
rs367629236 557 dbSNP
rs1022892630 567 dbSNP
rs1470611168 568 dbSNP
rs1006164799 572 dbSNP
rs1480181009 579 dbSNP
rs1172500059 581 dbSNP
rs1335810094 583 dbSNP
rs1410508662 584 dbSNP
rs973798788 591 dbSNP
rs1349530153 592 dbSNP
rs1398544925 595 dbSNP
rs962719719 597 dbSNP
rs1169788261 600 dbSNP
rs1015271499 611 dbSNP
rs888057132 612 dbSNP
rs1460543155 614 dbSNP
rs1254165971 615 dbSNP
rs982831031 617 dbSNP
rs1026977739 618 dbSNP
rs993713364 619 dbSNP
rs1482878646 620 dbSNP
rs1241737257 622 dbSNP
rs10076725 623 dbSNP
rs1040802579 624 dbSNP
rs1434107523 628 dbSNP
rs1198528720 633 dbSNP
rs1376435093 634 dbSNP
rs1253300941 654 dbSNP
rs762262432 662 dbSNP
rs889471055 665 dbSNP
rs996674927 670 dbSNP
rs1291803893 693 dbSNP
rs1247774196 694 dbSNP
rs1049452880 702 dbSNP
rs899658023 706 dbSNP
rs947018188 707 dbSNP
rs1427469748 711 dbSNP
rs1017672765 712 dbSNP
rs775103267 716 dbSNP
rs1000920222 718 dbSNP
rs914533991 726 dbSNP
rs1328148584 739 dbSNP
rs1042396478 740 dbSNP
rs1390712348 745 dbSNP
rs141492259 752 dbSNP
rs1164270183 753 dbSNP
rs1203351219 762 dbSNP
rs187550357 763 dbSNP
rs1056726827 764 dbSNP
rs1383603435 765 dbSNP
rs1191013606 767 dbSNP
rs1265650860 772 dbSNP
rs938181577 782 dbSNP
rs1162828019 790 dbSNP
rs1470718877 791 dbSNP
rs1365867145 795 dbSNP
rs1180312221 797 dbSNP
rs576168723 805 dbSNP
rs1447121864 818 dbSNP
rs538531291 826 dbSNP
rs1038516828 829 dbSNP
rs1269020728 842 dbSNP
rs941137259 843 dbSNP
rs908248081 846 dbSNP
rs982477207 847 dbSNP
rs955206788 850 dbSNP
rs981504561 851 dbSNP
rs922546589 855 dbSNP
rs1223932325 859 dbSNP
rs970144740 860 dbSNP
rs1264096736 865 dbSNP
rs1487053111 867 dbSNP
rs975288375 871 dbSNP
rs915977917 872 dbSNP
rs182613483 873 dbSNP
rs952132273 875 dbSNP
rs1032827550 878 dbSNP
rs1026572964 879 dbSNP
rs1277508957 883 dbSNP
rs1162250724 884 dbSNP
rs1227761034 885 dbSNP
rs1346036018 889 dbSNP
rs549705852 891 dbSNP
rs968170480 893 dbSNP
rs1386388361 894 dbSNP
rs1454472502 894 dbSNP
rs1338825334 895 dbSNP
rs1379956865 895 dbSNP
rs77057331 896 dbSNP
rs1021451803 899 dbSNP
rs1310838613 902 dbSNP
rs994114756 903 dbSNP
rs1229406355 905 dbSNP
rs1267856680 906 dbSNP
rs377712455 907 dbSNP
rs140959227 909 dbSNP
rs1491236959 909 dbSNP
rs531801033 909 dbSNP
rs761171273 909 dbSNP
rs769297025 909 dbSNP
rs878918947 909 dbSNP
rs879098564 909 dbSNP
rs966257136 909 dbSNP
rs1158187591 910 dbSNP
rs1491407396 910 dbSNP
rs1409448297 913 dbSNP
rs1009607267 916 dbSNP
rs1176684332 918 dbSNP
rs1359881969 939 dbSNP
rs1323173839 949 dbSNP
rs1401451807 950 dbSNP
rs529775372 955 dbSNP
rs1332620575 959 dbSNP
rs1387652838 960 dbSNP
rs1019095974 961 dbSNP
rs1410637950 967 dbSNP
rs1007721537 976 dbSNP
rs889565360 987 dbSNP
rs1157156751 990 dbSNP
rs75192015 992 dbSNP
rs1430596989 998 dbSNP
rs114639834 1002 dbSNP
rs527529030 1009 dbSNP
rs1252514613 1013 dbSNP
rs775979686 1016 dbSNP
rs1245585526 1021 dbSNP
rs1180974856 1023 dbSNP
rs905419778 1028 dbSNP
rs1448349612 1029 dbSNP
rs1481291720 1033 dbSNP
rs1191483290 1034 dbSNP
rs1272577779 1040 dbSNP
rs1424386597 1045 dbSNP
rs1281936463 1058 dbSNP
rs1038550236 1060 dbSNP
rs1372465054 1061 dbSNP
rs1430709821 1062 dbSNP
rs1307654568 1076 dbSNP
rs1207863593 1079 dbSNP
rs745367144 1083 dbSNP
rs934543000 1085 dbSNP
rs1285118307 1087 dbSNP
rs760396942 1092 dbSNP
rs1217945826 1095 dbSNP
rs775283238 1097 dbSNP
rs1297161503 1098 dbSNP
rs1342237586 1099 dbSNP
rs1045565409 1100 dbSNP
rs1365605930 1103 dbSNP
rs1490720753 1109 dbSNP
rs1222053860 1122 dbSNP
rs1245869824 1124 dbSNP
rs9333 1135 dbSNP
rs933700138 1143 dbSNP
rs1188193259 1151 dbSNP
rs1392177444 1161 dbSNP
rs1167977530 1163 dbSNP
rs745667837 1169 dbSNP
rs1368972846 1170 dbSNP
rs1407254236 1174 dbSNP
rs1324666211 1180 dbSNP
rs1431794491 1189 dbSNP
rs916028637 1192 dbSNP
rs984805200 1193 dbSNP
rs1300438845 1197 dbSNP
rs1316759226 1206 dbSNP
rs922286380 1210 dbSNP
rs1407217430 1211 dbSNP
rs1179251874 1213 dbSNP
rs952080814 1214 dbSNP
rs975026850 1218 dbSNP
rs114600862 1222 dbSNP
rs1358060939 1227 dbSNP
rs972357624 1239 dbSNP
rs531454576 1240 dbSNP
rs1288957889 1242 dbSNP
rs978654765 1250 dbSNP
rs1019193084 1251 dbSNP
rs1248585458 1252 dbSNP
rs1464350741 1278 dbSNP
rs1007770849 1281 dbSNP
rs1388367992 1291 dbSNP
rs953519597 1294 dbSNP
rs1028085656 1302 dbSNP
rs1187468485 1305 dbSNP
rs1011703771 1309 dbSNP
rs892815514 1313 dbSNP
rs1031781956 1314 dbSNP
rs1461627144 1316 dbSNP
rs1403957746 1317 dbSNP
rs562761735 1326 dbSNP
rs1010051170 1331 dbSNP
rs1322898860 1332 dbSNP
rs1390046779 1334 dbSNP
rs1434955638 1342 dbSNP
rs960750969 1345 dbSNP
rs998513405 1346 dbSNP
rs1002165294 1347 dbSNP
rs907168414 1348 dbSNP
rs1045613788 1350 dbSNP
rs1353752981 1352 dbSNP
rs948562069 1356 dbSNP
rs1287734 1357 dbSNP
rs1278083833 1358 dbSNP
rs1328442251 1359 dbSNP
rs1215229440 1364 dbSNP
rs1246326144 1367 dbSNP
rs1049151086 1373 dbSNP
rs148740556 1374 dbSNP
rs919338672 1381 dbSNP
rs554270524 1394 dbSNP
rs777784152 1397 dbSNP
rs1413118069 1400 dbSNP
rs1384019143 1408 dbSNP
rs1457234336 1413 dbSNP
rs1157589973 1414 dbSNP
rs1339081812 1416 dbSNP
rs944723848 1418 dbSNP
rs1359092308 1425 dbSNP
rs1171664028 1426 dbSNP
rs2578636 1433 dbSNP
rs75698136 1442 dbSNP
rs986348759 1444 dbSNP
rs1411241640 1449 dbSNP
rs1288805396 1450 dbSNP
rs1349636511 1453 dbSNP
rs1416717939 1457 dbSNP
rs1257691804 1462 dbSNP
rs146518252 1466 dbSNP
rs200468123 1466 dbSNP
rs1201125786 1469 dbSNP
rs953529549 1472 dbSNP
rs1484834581 1476 dbSNP
rs781239767 1477 dbSNP
rs1184582511 1478 dbSNP
rs1472473449 1480 dbSNP
rs1180400265 1481 dbSNP
rs1379906827 1486 dbSNP
rs752576910 1487 dbSNP
rs1244785573 1488 dbSNP
rs1171527918 1494 dbSNP
rs942364709 1498 dbSNP
rs1431312422 1499 dbSNP
rs1308255998 1508 dbSNP
rs925913933 1509 dbSNP
rs979066518 1512 dbSNP
rs1303070954 1513 dbSNP
rs1331639580 1519 dbSNP
rs945927941 1522 dbSNP
rs1274384521 1523 dbSNP
rs1345815653 1526 dbSNP
rs913067741 1538 dbSNP
rs1275642471 1541 dbSNP
rs1022449339 1558 dbSNP
rs1194472794 1559 dbSNP
rs779277348 1560 dbSNP
rs374331854 1564 dbSNP
rs1434302878 1574 dbSNP
rs1198759671 1582 dbSNP
rs755117741 1583 dbSNP
rs989650599 1585 dbSNP
rs1450798188 1587 dbSNP
rs1168605410 1592 dbSNP
rs957371016 1596 dbSNP
rs1427374230 1597 dbSNP
rs1295108866 1598 dbSNP
rs1031416339 1603 dbSNP
rs191194091 1604 dbSNP
rs1228009288 1605 dbSNP
rs1360403355 1623 dbSNP
rs1035067555 1624 dbSNP
rs1230735611 1625 dbSNP
rs541524548 1627 dbSNP
rs1298376735 1629 dbSNP
rs1317689224 1634 dbSNP
rs369995282 1635 dbSNP
rs998959137 1637 dbSNP
rs1267667417 1641 dbSNP
rs906841457 1643 dbSNP
rs1024177565 1644 dbSNP
rs969375390 1649 dbSNP
rs1251695575 1650 dbSNP
rs1017214722 1664 dbSNP
rs1006230189 1666 dbSNP
rs1299273470 1669 dbSNP
rs149701467 1680 dbSNP
rs1012760992 1681 dbSNP
rs1166451425 1684 dbSNP
rs1368218430 1689 dbSNP
rs558343788 1691 dbSNP
rs1306839161 1692 dbSNP
rs553513232 1700 dbSNP
rs538544735 1705 dbSNP
rs577309009 1706 dbSNP
rs1321361284 1714 dbSNP
rs1026236714 1722 dbSNP
rs780270422 1724 dbSNP
rs1423037132 1726 dbSNP
rs1408395944 1730 dbSNP
rs1315115889 1737 dbSNP
rs1178904773 1738 dbSNP
rs1479605514 1757 dbSNP
rs1249765848 1760 dbSNP
rs1204521944 1768 dbSNP
rs1244544230 1769 dbSNP
rs1271614948 1773 dbSNP
rs1209880160 1790 dbSNP
rs1246938746 1794 dbSNP
rs755312488 1798 dbSNP
rs900966749 1799 dbSNP
rs1039427011 1806 dbSNP
rs942395831 1823 dbSNP
rs1422841018 1824 dbSNP
rs1162580299 1828 dbSNP
rs1413875025 1829 dbSNP
rs1457758062 1840 dbSNP
rs897947094 1841 dbSNP
rs904181366 1848 dbSNP
rs1042698724 1869 dbSNP
rs1321519947 1871 dbSNP
rs945971470 1873 dbSNP
rs144266656 1874 dbSNP
rs539979812 1878 dbSNP
rs993076613 1881 dbSNP
rs1287224196 1883 dbSNP
rs1229615852 1885 dbSNP
rs1268069727 1885 dbSNP
rs1315605939 1895 dbSNP
rs1211663128 1899 dbSNP
rs3995688 1908 dbSNP
rs911857097 1909 dbSNP
rs980833969 1912 dbSNP
rs75030583 1918 dbSNP
rs1405729179 1920 dbSNP
rs375244237 1927 dbSNP
rs1017369082 1928 dbSNP
rs1345624249 1929 dbSNP
rs1160980721 1936 dbSNP
rs1434394434 1938 dbSNP
rs1311282697 1939 dbSNP
rs1372566346 1940 dbSNP
rs1471607777 1944 dbSNP
rs984100042 1955 dbSNP
rs1199989069 1958 dbSNP
rs1287735 1962 dbSNP
rs1221417228 1963 dbSNP
rs1371863787 1963 dbSNP
rs1025889041 1967 dbSNP
rs1271077356 1968 dbSNP
rs1311099640 1974 dbSNP
rs547507947 1983 dbSNP
rs956886348 1985 dbSNP
rs1204215844 1986 dbSNP
rs1031844352 1987 dbSNP
rs1478993755 1988 dbSNP
rs977157064 1988 dbSNP
rs1426041270 1992 dbSNP
rs868785625 1997 dbSNP
rs1018005460 1998 dbSNP
rs1392292051 2000 dbSNP
rs537957483 2004 dbSNP
rs556803056 2006 dbSNP
rs760841142 2007 dbSNP
rs1006606235 2014 dbSNP
rs904247077 2016 dbSNP
rs1439301719 2017 dbSNP
rs763626402 2018 dbSNP
rs760270635 2022 dbSNP
rs1370834544 2023 dbSNP
rs4452536 2024 dbSNP
rs1224622736 2027 dbSNP
rs1012525631 2033 dbSNP
rs1227182761 2034 dbSNP
rs1298537253 2035 dbSNP
rs958641140 2036 dbSNP
rs1453106218 2043 dbSNP
rs1027572092 2044 dbSNP
rs1385913321 2051 dbSNP
rs1467055450 2052 dbSNP
rs1362221725 2054 dbSNP
rs995115469 2057 dbSNP
rs28522623 2063 dbSNP
rs1450391207 2079 dbSNP
rs1290475627 2080 dbSNP
rs891740346 2085 dbSNP
rs1407453786 2093 dbSNP
rs1057068015 2095 dbSNP
rs1394433362 2097 dbSNP
rs1439303484 2101 dbSNP
rs1365270599 2104 dbSNP
rs775231616 2105 dbSNP
rs1268048566 2111 dbSNP
rs571111515 2113 dbSNP
rs927124123 2119 dbSNP
rs551133250 2120 dbSNP
rs1270167801 2126 dbSNP
rs1036857703 2138 dbSNP
rs1465405374 2141 dbSNP
rs1008963097 2145 dbSNP
rs890475870 2146 dbSNP
rs759276873 2153 dbSNP
rs1182844088 2157 dbSNP
rs1287736 2162 dbSNP
rs931966343 2170 dbSNP
rs984563646 2171 dbSNP
rs915512636 2175 dbSNP
rs951412238 2177 dbSNP
rs918859966 2186 dbSNP
rs976961351 2188 dbSNP
rs965569656 2190 dbSNP
rs369921044 2192 dbSNP
rs1292515826 2195 dbSNP
rs1054007420 2196 dbSNP
rs1006972660 2202 dbSNP
rs1229932201 2206 dbSNP
rs935498419 2209 dbSNP
rs1262709899 2214 dbSNP
rs1190680800 2217 dbSNP
rs1204664336 2220 dbSNP
rs1282203006 2225 dbSNP
rs968878626 2226 dbSNP
rs1211070645 2237 dbSNP
rs1463849628 2242 dbSNP
rs1257335731 2248 dbSNP
rs1267844992 2259 dbSNP
rs1474431935 2262 dbSNP
rs1204919585 2266 dbSNP
rs1413370943 2271 dbSNP
rs185947329 2273 dbSNP
rs1326245045 2280 dbSNP
rs181530928 2282 dbSNP
rs1231872058 2286 dbSNP
rs977585498 2293 dbSNP
rs1403708707 2298 dbSNP
rs1307509830 2305 dbSNP
rs1297282624 2313 dbSNP
rs149564186 2319 dbSNP
rs111585755 2321 dbSNP
rs1288705896 2322 dbSNP
rs1335139500 2339 dbSNP
rs540742612 2347 dbSNP
rs1454577313 2351 dbSNP
rs1347211228 2358 dbSNP
rs1399959353 2364 dbSNP
rs958359729 2367 dbSNP
rs1027993573 2371 dbSNP
rs1057100428 2390 dbSNP
rs994724960 2395 dbSNP
rs1002810232 2398 dbSNP
rs1251664965 2404 dbSNP
rs578110963 2406 dbSNP
rs1465608431 2409 dbSNP
rs1478077223 2416 dbSNP
rs1172422189 2419 dbSNP
rs962205243 2421 dbSNP
rs1392914944 2425 dbSNP
rs1170742525 2426 dbSNP
rs905740202 2427 dbSNP
rs1418187159 2428 dbSNP
rs1395486326 2432 dbSNP
rs1325446533 2433 dbSNP
rs1044259299 2439 dbSNP
rs941867033 2442 dbSNP
rs1302710393 2444 dbSNP
rs1014733367 2448 dbSNP
rs1346055803 2449 dbSNP
rs78471883 2458 dbSNP
rs909998693 2460 dbSNP
rs1008715935 2461 dbSNP
rs890582388 2462 dbSNP
rs1447869037 2464 dbSNP
rs1050490726 2470 dbSNP
rs1247844907 2475 dbSNP
rs996185305 2477 dbSNP
rs918605979 2479 dbSNP
rs564695115 2500 dbSNP
rs1254703991 2501 dbSNP
rs893768743 2504 dbSNP
rs911439282 2506 dbSNP
rs985626863 2507 dbSNP
rs749180887 2508 dbSNP
rs1440038780 2509 dbSNP
rs59526998 2510 dbSNP
rs988564991 2513 dbSNP
rs1341011927 2514 dbSNP
rs1296583062 2515 dbSNP
rs1326024960 2519 dbSNP
rs34162633 2525 dbSNP
rs771740244 2529 dbSNP
rs1046572907 2546 dbSNP
rs1247913102 2547 dbSNP
rs1035357929 2548 dbSNP
rs1213599757 2560 dbSNP
rs1002507225 2570 dbSNP
rs949553967 2573 dbSNP
rs1186530362 2577 dbSNP
rs1260631744 2578 dbSNP
rs1391851234 2582 dbSNP
rs1426322687 2585 dbSNP
rs905814333 2586 dbSNP
rs1418292612 2597 dbSNP
rs1460919118 2607 dbSNP
rs372144110 2613 dbSNP
rs991165364 2615 dbSNP
rs1408387549 2621 dbSNP
rs1390677310 2622 dbSNP
rs1022886725 2623 dbSNP
rs1289482844 2625 dbSNP
rs1397367282 2626 dbSNP
rs1361576576 2635 dbSNP
rs1006491917 2636 dbSNP
rs1315342937 2646 dbSNP
rs1356500138 2647 dbSNP
rs887606672 2650 dbSNP
rs138190115 2654 dbSNP
rs958621037 2660 dbSNP
rs930092601 2663 dbSNP
rs1215922732 2672 dbSNP
rs897204898 2684 dbSNP
rs1201818824 2685 dbSNP
rs145904725 2691 dbSNP
rs973743416 2704 dbSNP
rs1185471044 2713 dbSNP
rs535762197 2714 dbSNP
rs1473982481 2718 dbSNP
rs947572329 2722 dbSNP
rs914759543 2723 dbSNP
rs1376226127 2734 dbSNP
rs1414572417 2750 dbSNP
rs989345578 2754 dbSNP
rs1299424 2755 dbSNP
rs1352906081 2760 dbSNP
rs73741362 2766 dbSNP
rs987334315 2770 dbSNP
rs1438866729 2771 dbSNP
rs570500146 2779 dbSNP
rs1314619322 2784 dbSNP
rs1253429358 2787 dbSNP
rs1202391179 2788 dbSNP
rs1485120030 2797 dbSNP
rs1482407262 2804 dbSNP
rs769020246 2819 dbSNP
rs1253680311 2821 dbSNP
rs1480953809 2822 dbSNP
rs553303220 2833 dbSNP
rs747115407 2835 dbSNP
rs1029082217 2837 dbSNP
rs1417413746 2849 dbSNP
rs969692141 2850 dbSNP
rs1283361220 2854 dbSNP
rs1434307484 2855 dbSNP
rs1022915840 2857 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_138809 | 3UTR | CCGAGGUGGGUGGAUCACUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_138809 | 3UTR | CACUUGAGGUCAGGAGUUCAAGACCAGCCUGGCCAACAUGGUGAAACCCCAUCUCUACUAAAAAUAUAAAAAUCAGCCGGGCAUGGUGGCAUGUGCCUGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_138809 | 3UTR | CUUUGGGAGGCCGAGGUGGGUGGAUCACUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000296658.3 | 3UTR | CAAAGUGGGUGGAUCACCUGAGGUCAGGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000296658.3 | 3UTR | AAAGUGGGUGGAUCACCUGAGGUCAGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000296658.3 | 3UTR | AAAGUGGGUGGAUCACCUGAGGUCAGGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000296658.3 | 3UTR | AAGUGGGUGGAUCACCUGAGGUCAGGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000296658.3 | 3UTR | AAGUGGGUGGAUCACCUGAGGUCAGGAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.703 6.4e-5 0.689 9.8e-5 24 Click to see details
GSE17306 Multiple myeloma 0.327 1.1e-2 0.312 1.5e-2 49 Click to see details
GSE42095 Differentiated embryonic stem cells -0.336 5.8e-2 0.000 5.0e-1 23 Click to see details
GSE21687 Ependynoma primary tumors 0.183 7.4e-2 0.037 3.9e-1 64 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.289 8.1e-2 -0.296 7.5e-2 25 Click to see details
GSE19350 CNS germ cell tumors 0.429 8.2e-2 0.622 1.5e-2 12 Click to see details
GSE38226 Liver fibrosis 0.282 1.1e-1 0.129 2.9e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.217 1.2e-1 0.295 5.1e-2 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.238 1.3e-1 -0.237 1.3e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.2 2.0e-1 -0.380 4.9e-2 20 Click to see details
GSE14794 Lymphoblastoid cells -0.065 2.7e-1 -0.050 3.2e-1 90 Click to see details
GSE28260 Renal cortex and medulla -0.162 3.0e-1 -0.120 3.5e-1 13 Click to see details
GSE27834 Pluripotent stem cells 0.116 3.3e-1 0.053 4.2e-1 16 Click to see details
GSE19783 ER+ ER+ breast cancer 0.074 3.8e-1 -0.011 4.8e-1 20 Click to see details
GSE19536 Breast cancer -0.009 4.6e-1 0.070 2.4e-1 100 Click to see details
GSE26953 Aortic valvular endothelial cells 0.015 4.7e-1 -0.016 4.7e-1 24 Click to see details
GSE19783 ER- ER- breast cancer -0.001 5.0e-1 0.087 2.2e-1 79 Click to see details
GSE19783 ER- ER- breast cancer -0.001 5.0e-1 0.087 2.2e-1 79 Click to see details
GSE19783 ER- ER- breast cancer -0.001 5.0e-1 0.087 2.2e-1 79 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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