pre-miRNA Information
pre-miRNA hsa-mir-4680   
Genomic Coordinates chr10: 110898090 - 110898155
Description Homo sapiens miR-4680 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4680-5p
Sequence 5| AGAACUCUUGCAGUCUUAGAUGU |27
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1274530692 2 dbSNP
rs780271274 5 dbSNP
rs1461423681 7 dbSNP
rs749729920 8 dbSNP
rs1252920446 10 dbSNP
rs201739274 11 dbSNP
rs774971106 19 dbSNP
rs748132091 22 dbSNP
rs773643180 22 dbSNP
rs1235425484 23 dbSNP
Putative Targets

Gene Information
Gene Symbol PIGG   
Synonyms GPI7, LAS21, MRT53, PRO4405, RLGS1930
Description phosphatidylinositol glycan anchor biosynthesis class G
Transcript NM_001127178   
Other Transcripts NM_017733   
Expression
Putative miRNA Targets on PIGG
3'UTR of PIGG
(miRNA target sites are highlighted)
>PIGG|NM_001127178|3'UTR
   1 ACTAAGCTGAACACTGGAAAAATAATACATGCTTAAAGTCTGCTGTTATTCTAAAATGAAAGATATGAATTCAACAAAGT
  81 TGATGGATAACTTTCTTTGACTGCTCTACCTGAATTTAGACTAAGCAGTAAATAGTTTAATAAAAGATCACTTTAATATA
 161 CAGTTTGTATCATATTTTCCCCCATTGACAATCACTCTAGAAGCTTCTGAACTTTTAATTTCCTCTGAATAAGCTATGGT
 241 GTGACCCAAATATGTGTGTTTAAATCAATGAATGAAAAGGTTCTGGACTTTGTTAGAGTCCAGGAGCTCTGTGGGAGGAG
 321 GCACCCAGATTACCTTAGGGAGCACAGAGCTCTTAGAATCCTACAAACCACTGAGGGCCCCAAGGCGCTTTGGTTTATGA
 401 GGGTTACATGTATCAGTGTTTATGGCATTTGAGATGAAAACTAAGATAAAAAAGTATTCATTTATAAGGAATCTATTGCA
 481 TATTAATGAAACACTTGAAGGAAAAGTAACTATATTTTCCAAAACAAAAAAATTCAGTGAGACCCAGCACTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uguAGAUUCUG--ACGUUCUCAAGa 5'
             ||| :|||  ||: ||||| | 
Target 5' ggtTCT-GGACTTTGTTAGAGTCCa 3'
279 - 302 129.00 -9.30
2
miRNA  3' ugUAGAUUCUGACGU-UCUCAAGa 5'
            | || ||:  ||| |||| || 
Target 5' ttACCTTAGGGAGCACAGAGCTCt 3'
330 - 353 129.00 -11.70
3
miRNA  3' ugUAGAUUCUGA--CG----UUCUCAAGa 5'
            ||:| |||||  ||    || ||||: 
Target 5' gaATTT-AGACTAAGCAGTAAATAGTTTa 3'
112 - 139 116.00 -6.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30729771 38 COSMIC
COSN31493045 120 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1323458228 3 dbSNP
rs1340306389 9 dbSNP
rs757297286 11 dbSNP
rs1250239197 13 dbSNP
rs779001075 15 dbSNP
rs370693485 16 dbSNP
rs536289163 22 dbSNP
rs775829099 23 dbSNP
rs1416428885 26 dbSNP
rs375113747 27 dbSNP
rs768563741 29 dbSNP
rs201141197 31 dbSNP
rs761764257 34 dbSNP
rs1422990099 36 dbSNP
rs754522919 38 dbSNP
rs1410247006 41 dbSNP
rs764687990 44 dbSNP
rs772821113 50 dbSNP
rs931714524 51 dbSNP
rs1465321408 52 dbSNP
rs1368429152 53 dbSNP
rs1189320723 56 dbSNP
rs762430317 57 dbSNP
rs1381128393 60 dbSNP
rs1217952254 67 dbSNP
rs1242638948 69 dbSNP
rs1051990528 80 dbSNP
rs189423907 82 dbSNP
rs1204888003 88 dbSNP
rs1189274303 98 dbSNP
rs1438616072 98 dbSNP
rs1208157792 102 dbSNP
rs912058961 103 dbSNP
rs940866531 104 dbSNP
rs1235114843 107 dbSNP
rs533680425 111 dbSNP
rs922595062 114 dbSNP
rs1348550084 123 dbSNP
rs150660544 127 dbSNP
rs934029936 129 dbSNP
rs1442588561 132 dbSNP
rs985393903 143 dbSNP
rs911092069 147 dbSNP
rs946666907 152 dbSNP
rs1404361546 157 dbSNP
rs181943555 159 dbSNP
rs752619664 160 dbSNP
rs1166447178 162 dbSNP
rs930901643 164 dbSNP
rs1358773575 169 dbSNP
rs1402526811 170 dbSNP
rs1470689953 179 dbSNP
rs77141464 186 dbSNP
rs1234848630 188 dbSNP
rs755972395 196 dbSNP
rs1451233862 207 dbSNP
rs777385522 209 dbSNP
rs1273957735 210 dbSNP
rs1215561900 220 dbSNP
rs1327007508 225 dbSNP
rs1267371413 226 dbSNP
rs894469874 227 dbSNP
rs868840413 230 dbSNP
rs902366110 240 dbSNP
rs7668455 242 dbSNP
rs1056259739 247 dbSNP
rs1327338455 254 dbSNP
rs1432189217 264 dbSNP
rs557388429 265 dbSNP
rs1387119476 269 dbSNP
rs1158969953 275 dbSNP
rs896150257 281 dbSNP
rs78564001 287 dbSNP
rs1372160007 290 dbSNP
rs1234648693 291 dbSNP
rs1023309398 292 dbSNP
rs1463565795 293 dbSNP
rs140823596 297 dbSNP
rs757458048 301 dbSNP
rs957915701 317 dbSNP
rs1318643153 325 dbSNP
rs1224982785 327 dbSNP
rs1276326343 332 dbSNP
rs989808961 339 dbSNP
rs1005820526 348 dbSNP
rs1348171220 352 dbSNP
rs779188246 362 dbSNP
rs1017502305 374 dbSNP
rs775786071 376 dbSNP
rs1305113182 378 dbSNP
rs185727802 387 dbSNP
rs1363883776 388 dbSNP
rs1450998526 395 dbSNP
rs1432189827 404 dbSNP
rs1028657637 411 dbSNP
rs1332619997 414 dbSNP
rs1434433242 415 dbSNP
rs953198699 416 dbSNP
rs1175798947 420 dbSNP
rs573332613 423 dbSNP
rs1447863825 429 dbSNP
rs1418964118 441 dbSNP
rs1211709163 455 dbSNP
rs1486809107 459 dbSNP
rs540372530 469 dbSNP
rs1209917572 472 dbSNP
rs746001500 476 dbSNP
rs1282160952 478 dbSNP
rs1202652768 482 dbSNP
rs1029742738 485 dbSNP
rs369671155 488 dbSNP
rs376238577 488 dbSNP
rs879690470 488 dbSNP
rs7437016 489 dbSNP
rs7441980 490 dbSNP
rs1364720401 496 dbSNP
rs1282899113 500 dbSNP
rs911242911 501 dbSNP
rs946605512 508 dbSNP
rs1362291718 511 dbSNP
rs1315160485 513 dbSNP
rs1428135442 519 dbSNP
rs556136019 521 dbSNP
rs1354087340 526 dbSNP
rs142114614 526 dbSNP
rs1430333625 535 dbSNP
rs201018006 536 dbSNP
rs979400258 537 dbSNP
rs550786248 541 dbSNP
rs1404142884 544 dbSNP
rs935190740 545 dbSNP
rs1480111282 546 dbSNP
rs950121560 548 dbSNP
rs1328506992 555 dbSNP
rs1056312909 556 dbSNP
rs747473570 566 dbSNP
rs1206043997 567 dbSNP
rs1395765660 570 dbSNP
rs1319443435 571 dbSNP
rs562421394 578 dbSNP
rs1446517220 581 dbSNP
rs1233272186 596 dbSNP
rs367710168 612 dbSNP
rs1045728033 614 dbSNP
rs1408324886 614 dbSNP
rs1372901376 616 dbSNP
rs1298921411 619 dbSNP
rs769086216 620 dbSNP
rs1348262047 624 dbSNP
rs760376767 627 dbSNP
rs1461962710 655 dbSNP
rs776907171 659 dbSNP
rs887475881 660 dbSNP
rs529983721 665 dbSNP
rs1030754621 666 dbSNP
rs1250929037 670 dbSNP
rs1178622678 671 dbSNP
rs893682921 673 dbSNP
rs1010817409 675 dbSNP
rs563071866 684 dbSNP
rs1336125584 692 dbSNP
rs1274979794 693 dbSNP
rs953053932 694 dbSNP
rs1237373909 699 dbSNP
rs75849986 702 dbSNP
rs897329252 704 dbSNP
rs1393419439 707 dbSNP
rs1248099431 717 dbSNP
rs144681652 722 dbSNP
rs1325310393 723 dbSNP
rs149985304 735 dbSNP
rs1029794957 745 dbSNP
rs1237039292 752 dbSNP
rs1474266664 756 dbSNP
rs1156902257 759 dbSNP
rs1452937430 761 dbSNP
rs1364223126 765 dbSNP
rs1161012558 767 dbSNP
rs1431099119 775 dbSNP
rs1251927036 777 dbSNP
rs1167114654 779 dbSNP
rs760629871 781 dbSNP
rs1419228407 785 dbSNP
rs1465520306 786 dbSNP
rs566141186 787 dbSNP
rs955432648 789 dbSNP
rs1399044247 794 dbSNP
rs1261752566 803 dbSNP
rs398082809 803 dbSNP
rs398092111 803 dbSNP
rs71654589 803 dbSNP
rs1346015159 806 dbSNP
rs1235254186 809 dbSNP
rs1302897237 809 dbSNP
rs1329114657 815 dbSNP
rs1339443868 829 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugUAGAUUCUGACGUUCUCaaga 5'
            | ||:||::  ||:|||    
Target 5' ucACCUGAGGU--CAGGAG---- 3'
9 - 25
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000296306.7 | 3UTR | GGGGCAGAUCACCUGAGGUCAGGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
133 hsa-miR-4680-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT378771 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT393867 ZDHHC21 zinc finger DHHC-type containing 21 2 4
MIRT446684 C2CD2 C2 calcium dependent domain containing 2 2 2
MIRT447600 MRPL3 mitochondrial ribosomal protein L3 2 2
MIRT450708 RNF152 ring finger protein 152 2 2
MIRT450784 PAPOLG poly(A) polymerase gamma 2 2
MIRT454623 COL23A1 collagen type XXIII alpha 1 chain 2 8
MIRT461620 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT462695 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT475530 HOXA3 homeobox A3 2 8
MIRT475739 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT489676 CYP1A1 cytochrome P450 family 1 subfamily A member 1 2 2
MIRT490610 SLC47A1 solute carrier family 47 member 1 2 2
MIRT493628 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT496152 RPS15A ribosomal protein S15a 2 2
MIRT499232 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT501496 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT507163 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT512389 MTRNR2L1 MT-RNR2-like 1 2 4
MIRT514626 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT517474 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT525332 CNGB1 cyclic nucleotide gated channel beta 1 2 2
MIRT526685 BAK1 BCL2 antagonist/killer 1 2 2
MIRT527317 CCR2 C-C motif chemokine receptor 2 2 2
MIRT527608 EYS eyes shut homolog (Drosophila) 2 2
MIRT528794 RAB32 RAB32, member RAS oncogene family 2 2
MIRT531048 TIPARP TCDD inducible poly(ADP-ribose) polymerase 2 2
MIRT532254 TBPL2 TATA-box binding protein like 2 2 2
MIRT533801 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT535887 MLEC malectin 2 2
MIRT540704 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT544645 PHF8 PHD finger protein 8 2 4
MIRT545760 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT555310 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT555877 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT559507 ARID5B AT-rich interaction domain 5B 2 2
MIRT560448 SLC30A7 solute carrier family 30 member 7 2 2
MIRT561262 ZIK1 zinc finger protein interacting with K protein 1 2 2
MIRT561795 PAWR pro-apoptotic WT1 regulator 2 2
MIRT567007 KLHL15 kelch like family member 15 2 2
MIRT569298 SURF6 surfeit 6 2 2
MIRT570606 MTRNR2L11 MT-RNR2-like 11 2 2
MIRT572888 ADCY2 adenylate cyclase 2 2 2
MIRT573119 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif 18 2 2
MIRT608332 ZNF670 zinc finger protein 670 2 6
MIRT614942 KCNK5 potassium two pore domain channel subfamily K member 5 2 2
MIRT615324 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT618441 ZNF800 zinc finger protein 800 2 2
MIRT620110 HARBI1 harbinger transposase derived 1 2 2
MIRT626008 ZNF517 zinc finger protein 517 2 2
MIRT626626 SLC30A6 solute carrier family 30 member 6 2 2
MIRT627842 POU3F1 POU class 3 homeobox 1 2 2
MIRT628386 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT629305 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT629864 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630444 IDE insulin degrading enzyme 2 2
MIRT631854 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT633173 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT633477 ZNF724P zinc finger protein 724 2 2
MIRT634395 PLSCR1 phospholipid scramblase 1 2 2
MIRT635538 TRIM72 tripartite motif containing 72 2 2
MIRT635821 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT636169 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636797 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT637952 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT645136 HES2 hes family bHLH transcription factor 2 2 2
MIRT645667 ADK adenosine kinase 2 2
MIRT646148 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT647004 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT648187 C2orf68 chromosome 2 open reading frame 68 2 2
MIRT650090 TERF2 telomeric repeat binding factor 2 2 2
MIRT650329 RTN2 reticulon 2 2 2
MIRT654224 RNF165 ring finger protein 165 2 2
MIRT654545 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT656457 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT656828 KLF8 Kruppel like factor 8 2 2
MIRT657112 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein like 2 2 2
MIRT657930 GATSL2 cytosolic arginine sensor for mTORC1 subunit 2 2 2
MIRT659375 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT659833 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT662108 LACTB lactamase beta 2 4
MIRT662789 TBC1D25 TBC1 domain family member 25 2 2
MIRT669501 ARL3 ADP ribosylation factor like GTPase 3 2 2
MIRT669759 ZNF101 zinc finger protein 101 2 4
MIRT669800 GAN gigaxonin 2 2
MIRT670050 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT670299 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670388 EMP2 epithelial membrane protein 2 2 2
MIRT672862 C22orf29 retrotransposon Gag like 10 2 2
MIRT672890 FXN frataxin 2 2
MIRT673210 C10orf76 chromosome 10 open reading frame 76 2 2
MIRT674001 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT674163 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674502 TIRAP TIR domain containing adaptor protein 2 2
MIRT675470 NUBPL nucleotide binding protein like 2 2
MIRT675671 TMOD2 tropomodulin 2 2 2
MIRT676006 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT676074 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676386 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676764 SNX2 sorting nexin 2 2 2
MIRT676896 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT676978 ZNF708 zinc finger protein 708 2 2
MIRT677236 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677369 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677464 PDLIM3 PDZ and LIM domain 3 2 2
MIRT678081 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678093 ATCAY ATCAY, caytaxin 2 2
MIRT678324 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678417 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678521 ZNF347 zinc finger protein 347 2 2
MIRT678700 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT678829 PDE6A phosphodiesterase 6A 2 2
MIRT679991 RUNDC1 RUN domain containing 1 2 2
MIRT680751 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT681249 ZNF383 zinc finger protein 383 2 2
MIRT681422 GTF3C6 general transcription factor IIIC subunit 6 2 2
MIRT681948 SLC19A3 solute carrier family 19 member 3 2 2
MIRT689278 C5AR2 complement component 5a receptor 2 2 2
MIRT690389 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT691845 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT693863 IYD iodotyrosine deiodinase 2 2
MIRT696002 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT701930 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT702341 KLHL7 kelch like family member 7 2 2
MIRT703557 FKBP14 FK506 binding protein 14 2 2
MIRT705033 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT706341 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT709671 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT711212 EFHB EF-hand domain family member B 2 2
MIRT718342 PURA purine rich element binding protein A 2 2
MIRT722755 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723535 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 2
MIRT724498 BFAR bifunctional apoptosis regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4680-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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