pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol CCL22   
Synonyms A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1
Description C-C motif chemokine ligand 22
Transcript NM_002990   
Expression
Putative miRNA Targets on CCL22
3'UTR of CCL22
(miRNA target sites are highlighted)
>CCL22|NM_002990|3'UTR
   1 AGAGCCTACTCTGATGACCGTGGCCTTGGCTCCTCCAGGAAGGCTCAGGAGCCCTACCTCCCTGCCATTATAGCTGCTCC
  81 CCGCCAGAAGCCTGTGCCAACTCTCTGCATTCCCTGATCTCCATCCCTGTGGCTGTCACCCTTGGTCACCTCCGTGCTGT
 161 CACTGCCATCTCCCCCCTGACCCCTCTAACCCATCCTCTGCCTCCCTCCCTGCAGTCAGAGGGTCCTGTTCCCATCAGCG
 241 ATTCCCCTGCTTAAACCCTTCCATGACTCCCCACTGCCCTAAGCTGAGGTCAGTCTCCCAAGCCTGGCATGTGGCCCTCT
 321 GGATCTGGGTTCCATCTCTGTCTCCAGCCTGCCCACTTCCCTTCATGAATGTTGGGTTCTAGCTCCCTGTTCTCCAAACC
 401 CATACTACACATCCCACTTCTGGGTCTTTGCCTGGGATGTTGCTGACACCCAGAAAGTCCCACCACCTGCACATGTGTAG
 481 CCCCACCAGCCCTCCAAGGCATTGCTCGCCCAAGCAGCTGGTAATTCCATTTCATGTATTAGATGTCCCCTGGCCCTCTG
 561 TCCCCTCTTAATAACCCTAGTCACAGTCTCCGCAGATTCTTGGGATTTGGGGGTTTTCTCCCCCACCTCTCCACTAGTTG
 641 GACCAAGGTTTCTAGCTAAGTTACTCTAGTCTCCAAGCCTCTAGCATAGAGCACTGCAGACAGGCCCTGGCTCAGAATCA
 721 GAGCCCAGAAAGTGGCTGCAGACAAAATCAATAAAACTAATGTCCCTCCCCTCTCCCTGCCAAAAGGCAGTTACATATCA
 801 ATACAGAGACTCAAGGTCACTAGAAATGGGCCAGCTGGGTCAATGTGAAGCCCCAAATTTGCCCAGATTCACCTTTCTTC
 881 CCCCACTCCCTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTCACCCACGCTGGAGTGCAATGGTGTGGTCTTG
 961 GCTTATTGAAGCCTCTGCCTCCTGGGTTCAAGTGATTCTCTTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTTCCTG
1041 CTACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACGAGGCTTCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGT
1121 CCTCAGGTAATCCGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACAGTGCCTGGCCTCTTCCCTCT
1201 CCCCACCCCCCCCCCAACTTTTTTTTTTTTTTATGGCAGGGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGAT
1281 CTCGGCTCACTACAACCTCGACCTCCTGGGTTCAAGCGATTCTCCCACCCCAGCCTCCCAAGTAGCTGGGATTACAGGTG
1361 TGTGCCACTACGGCTGGCTAATTTTTGTATTTTTAGTAGAGACAGGTTTCACCATATTGGCCAGGCTGGTCTTGAACTCC
1441 TGACCTCAAGTGATCCACCTTCCTTGTGCTCCCAAAGTGCTGAGATTACAGGCGTGAGCTATCACACCCAGCCTCCCCCT
1521 TTTTTTCCTAATAGGAGACTCCTGTACCTTTCTTCGTTTTACCTATGTGTCGTGTCTGCTTACATTTCCTTCTCCCCTCA
1601 GGCTTTTTTTGGGTGGTCCTCCAACCTCCAATACCCAGGCCTGGCCTCTTCAGAGTACCCCCCATTCCACTTTCCCTGCC
1681 TCCTTCCTTAAATAGCTGACAATCAAATTCATGCTATGGTGTGAAAGACTACCTTTGACTTGGTATTATAAGCTGGAGTT
1761 ATATATGTATTTGAAAACAGAGTAAATACTTAAGAGGCCAAATAGATGAATGGAAGAATTTTAGGAACTGTGAGAGGGGG
1841 ACAAGGTGGAGCTTTCCTGGCCCTGGGAGGAAGCTGGCTGTGGTAGCGTAGCGCTCTCTCTCTCTGTCTGTGGCAGGAGG
1921 CAAAGAGTAGGGTGTAATTGAGTGAAGGAATCCTGGGTAGAGACCATTCTCAGGTGGTTGGGCCAGGCTAAAGACTGGGA
2001 TTTGGGTCTATCTATGCCTTTCTGGCTGATTTTTGTAGAGACGGGGTTTTGCCATGTTACCCAGGCTGGTCTCAAACTCC
2081 TGGGCTCAAGCGATCCTCCTGGCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACTGCGCCTGGCTTCCTCTT
2161 CCTCTTGAGAAATATTCTTTTCATACAGCAAGTATGGGACAGCAGTGTCCCAGGTAAAGGACATAAATGTTACAAGTGTC
2241 TGGTCCTTTCTGAGGGAGGCTGGTGCCGCTCTGCAGGGTATTTGAACCTGTGGAATTGGAGGAGGCCATTTCACTCCCTG
2321 AACCCAGCCTGACAAATCACAGTGAGAATGTTCACCTTATAGGCTTGCTGTGGGGCTCAGGTTGAAAGTGTGGGGAGTGA
2401 CACTGCCTAGGCATCCAGCTCAGTGTCATCCAGGGCCTGTGTCCCTCCCGAACCCAGGGTCAACCTGCCTACCACAGGCA
2481 CTAGAAGGACGAATCTGCCTACTGCCCATGAACGGGGCCCTCAAGCGTCCTGGGATCTCCTTCTCCCTCCTGTCCTGTCC
2561 TTGCCCCTCAGGACTGCTGGAAAATAAATCCTTTAAAATAGTAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaccucucUCUCUCCGAGUCa 5'
                  ||: |||||||| 
Target 5' gctcctccAGGAAGGCTCAGg 3'
29 - 49 153.00 -15.50
2
miRNA  3' gaCCUCUCUCU--CUCCGAGUCa 5'
            | ||| ||:    ||||||| 
Target 5' ctGCAGACAGGCCCTGGCTCAGa 3'
694 - 716 149.00 -17.70
3
miRNA  3' gaccucucuCUCUCCGAGUCa 5'
                   | |:||||||| 
Target 5' aggcttgctGTGGGGCTCAGg 3'
2361 - 2381 148.00 -16.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30104339 6 COSMIC
COSN30492270 17 COSMIC
COSN30449873 33 COSMIC
COSN26969624 44 COSMIC
COSN29132791 57 COSMIC
COSN30134519 84 COSMIC
COSN15661734 98 COSMIC
COSN21182939 241 COSMIC
COSN16855816 323 COSMIC
COSN1701209 407 COSMIC
COSN26689101 846 COSMIC
COSN28198189 886 COSMIC
COSN27341872 1207 COSMIC
COSN19194361 1218 COSMIC
COSN22233395 1220 COSMIC
COSN23952516 1417 COSMIC
COSN15660767 1593 COSMIC
COSN5177013 1653 COSMIC
COSN8503003 1847 COSMIC
COSN23161016 1895 COSMIC
COSN15025528 1945 COSMIC
COSN8503004 2158 COSMIC
COSN25324080 2514 COSMIC
COSN15367203 2533 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs746610367 3 dbSNP
rs201050913 6 dbSNP
rs776190001 8 dbSNP
rs759032926 12 dbSNP
rs1406401917 14 dbSNP
rs1455898839 18 dbSNP
rs765205372 20 dbSNP
rs775459835 21 dbSNP
rs757253583 34 dbSNP
rs1432496110 39 dbSNP
rs1330422688 52 dbSNP
rs1037443738 57 dbSNP
rs1030098920 59 dbSNP
rs953083722 63 dbSNP
rs530767668 74 dbSNP
rs867197880 75 dbSNP
rs1291118175 76 dbSNP
rs552444943 83 dbSNP
rs190203232 84 dbSNP
rs963363313 85 dbSNP
rs1463223763 86 dbSNP
rs1421669264 87 dbSNP
rs974388884 92 dbSNP
rs918818794 114 dbSNP
rs1424311248 115 dbSNP
rs750114390 118 dbSNP
rs34722018 125 dbSNP
rs532498018 149 dbSNP
rs1251477779 150 dbSNP
rs1471851520 151 dbSNP
rs1221962074 154 dbSNP
rs547490406 155 dbSNP
rs981548798 158 dbSNP
rs1197526611 161 dbSNP
rs1179425909 163 dbSNP
rs1409414286 164 dbSNP
rs928743371 169 dbSNP
rs937388996 173 dbSNP
rs550822947 175 dbSNP
rs1055732358 177 dbSNP
rs564192415 178 dbSNP
rs914612575 178 dbSNP
rs1173291935 180 dbSNP
rs1443560027 182 dbSNP
rs947373511 200 dbSNP
rs1330905167 204 dbSNP
rs1434888732 205 dbSNP
rs1466245522 206 dbSNP
rs1041664141 207 dbSNP
rs903070641 214 dbSNP
rs1424299859 222 dbSNP
rs1194104239 235 dbSNP
rs532883204 240 dbSNP
rs1411476387 241 dbSNP
rs1223580811 243 dbSNP
rs1177657327 258 dbSNP
rs1457892065 267 dbSNP
rs1051556231 277 dbSNP
rs1252564132 288 dbSNP
rs1207334712 289 dbSNP
rs1312187476 304 dbSNP
rs1280044929 311 dbSNP
rs1279934555 316 dbSNP
rs376815927 320 dbSNP
rs1237019953 329 dbSNP
rs1375110605 330 dbSNP
rs888874177 333 dbSNP
rs1366764084 335 dbSNP
rs1447824287 343 dbSNP
rs565764409 345 dbSNP
rs1375728495 349 dbSNP
rs1217438723 351 dbSNP
rs1301176224 356 dbSNP
rs1299205436 366 dbSNP
rs1465607134 366 dbSNP
rs1350166220 373 dbSNP
rs1007348717 375 dbSNP
rs548131334 381 dbSNP
rs1235288149 383 dbSNP
rs35849109 390 dbSNP
rs1378272568 394 dbSNP
rs1177712330 401 dbSNP
rs1482264109 402 dbSNP
rs1419302058 403 dbSNP
rs963098150 418 dbSNP
rs1252224360 421 dbSNP
rs170360 451 dbSNP
rs569910237 455 dbSNP
rs1025911725 458 dbSNP
rs951609426 464 dbSNP
rs749486222 478 dbSNP
rs537248925 482 dbSNP
rs1396347646 486 dbSNP
rs768981907 497 dbSNP
rs559162996 501 dbSNP
rs1352086941 504 dbSNP
rs1454388322 505 dbSNP
rs1219857713 508 dbSNP
rs1290545606 509 dbSNP
rs1310834409 511 dbSNP
rs1395577432 522 dbSNP
rs1380017476 525 dbSNP
rs928774277 528 dbSNP
rs1416553417 533 dbSNP
rs41426048 537 dbSNP
rs1431277982 539 dbSNP
rs577479773 545 dbSNP
rs1454108627 546 dbSNP
rs1365231195 559 dbSNP
rs1162221699 565 dbSNP
rs991572870 568 dbSNP
rs1417982389 571 dbSNP
rs1189376533 590 dbSNP
rs914624047 592 dbSNP
rs947422489 593 dbSNP
rs1206155457 597 dbSNP
rs1487042487 606 dbSNP
rs1263945983 609 dbSNP
rs1349096540 610 dbSNP
rs1434143686 614 dbSNP
rs1295203208 615 dbSNP
rs1216867554 624 dbSNP
rs149238009 625 dbSNP
rs1297480960 628 dbSNP
rs1042087094 634 dbSNP
rs924552869 636 dbSNP
rs1295284677 638 dbSNP
rs1386906470 639 dbSNP
rs1291525498 642 dbSNP
rs774576791 648 dbSNP
rs1051672820 657 dbSNP
rs1056063094 675 dbSNP
rs1457109673 679 dbSNP
rs1418045645 682 dbSNP
rs1166556826 690 dbSNP
rs1476549478 694 dbSNP
rs1423612340 709 dbSNP
rs552674228 718 dbSNP
rs749216189 720 dbSNP
rs1007379596 733 dbSNP
rs1265719999 735 dbSNP
rs1209544451 743 dbSNP
rs1469123502 745 dbSNP
rs1275269204 758 dbSNP
rs1196882448 763 dbSNP
rs1317339190 767 dbSNP
rs1340250335 768 dbSNP
rs1216553231 777 dbSNP
rs1274082982 781 dbSNP
rs1270803331 788 dbSNP
rs1037486603 796 dbSNP
rs898884234 803 dbSNP
rs548515558 805 dbSNP
rs1386006027 806 dbSNP
rs377523389 811 dbSNP
rs1327482400 814 dbSNP
rs541938054 816 dbSNP
rs144628416 821 dbSNP
rs1468522522 822 dbSNP
rs78507648 834 dbSNP
rs1035901630 835 dbSNP
rs1376423120 839 dbSNP
rs958888951 851 dbSNP
rs992037787 857 dbSNP
rs1255169571 863 dbSNP
rs1177037714 865 dbSNP
rs1021729542 867 dbSNP
rs969167490 868 dbSNP
rs896022967 872 dbSNP
rs977456456 873 dbSNP
rs1412787740 882 dbSNP
rs1403433571 885 dbSNP
rs1014270305 886 dbSNP
rs1042088561 888 dbSNP
rs1456666510 889 dbSNP
rs1305312414 890 dbSNP
rs11405534 891 dbSNP
rs1231121021 891 dbSNP
rs1397296053 891 dbSNP
rs1400752455 891 dbSNP
rs1435841903 891 dbSNP
rs1319891325 892 dbSNP
rs1439324181 893 dbSNP
rs1363131697 894 dbSNP
rs1276661895 909 dbSNP
rs1271058355 912 dbSNP
rs1378862025 917 dbSNP
rs148490868 921 dbSNP
rs1254048103 922 dbSNP
rs1275467321 925 dbSNP
rs1336057936 927 dbSNP
rs933304717 936 dbSNP
rs1265636802 937 dbSNP
rs987406390 946 dbSNP
rs910456238 947 dbSNP
rs943198692 948 dbSNP
rs1279745546 951 dbSNP
rs1443790074 953 dbSNP
rs1338222075 958 dbSNP
rs1311692275 971 dbSNP
rs1037917818 973 dbSNP
rs1296808307 978 dbSNP
rs1419469634 987 dbSNP
rs1409054300 993 dbSNP
rs1160484322 1000 dbSNP
rs141775982 1001 dbSNP
rs1367995592 1002 dbSNP
rs929015410 1008 dbSNP
rs1188681232 1014 dbSNP
rs1485994687 1018 dbSNP
rs564371404 1019 dbSNP
rs1214237405 1028 dbSNP
rs1236582290 1045 dbSNP
rs371015520 1048 dbSNP
rs558501857 1049 dbSNP
rs528352627 1050 dbSNP
rs546907714 1052 dbSNP
rs1353748995 1058 dbSNP
rs1292138840 1068 dbSNP
rs1276833932 1080 dbSNP
rs1357979275 1080 dbSNP
rs576653011 1081 dbSNP
rs182510464 1082 dbSNP
rs1320639291 1085 dbSNP
rs1403829984 1090 dbSNP
rs771562025 1093 dbSNP
rs1165817601 1094 dbSNP
rs74390076 1099 dbSNP
rs1418308589 1111 dbSNP
rs1456584992 1112 dbSNP
rs1156925995 1121 dbSNP
rs759010451 1124 dbSNP
rs1382874826 1127 dbSNP
rs1191454275 1130 dbSNP
rs1402566622 1133 dbSNP
rs548229280 1135 dbSNP
rs1358753393 1137 dbSNP
rs1272134892 1140 dbSNP
rs569822305 1141 dbSNP
rs1213828379 1167 dbSNP
rs1446134215 1171 dbSNP
rs1275717822 1172 dbSNP
rs1214526629 1175 dbSNP
rs1341986731 1176 dbSNP
rs1272298162 1183 dbSNP
rs1295432755 1186 dbSNP
rs1370591445 1187 dbSNP
rs1326787250 1191 dbSNP
rs1463172540 1198 dbSNP
rs1398226561 1199 dbSNP
rs1184008934 1201 dbSNP
rs903166962 1201 dbSNP
rs1356523294 1204 dbSNP
rs1476907240 1204 dbSNP
rs1193914190 1205 dbSNP
rs1252035117 1205 dbSNP
rs1000265398 1206 dbSNP
rs1491331252 1206 dbSNP
rs373811356 1206 dbSNP
rs796165453 1206 dbSNP
rs796255674 1206 dbSNP
rs1394278227 1207 dbSNP
rs369352628 1207 dbSNP
rs57450696 1207 dbSNP
rs148517008 1208 dbSNP
rs57186204 1208 dbSNP
rs375455988 1209 dbSNP
rs867546666 1209 dbSNP
rs1287082368 1210 dbSNP
rs1330899609 1211 dbSNP
rs1353298846 1212 dbSNP
rs796911439 1212 dbSNP
rs537614594 1213 dbSNP
rs1301117221 1214 dbSNP
rs796311331 1214 dbSNP
rs1313334233 1215 dbSNP
rs1270536632 1216 dbSNP
rs866363216 1217 dbSNP
rs1028915978 1218 dbSNP
rs1260464790 1219 dbSNP
rs1421203776 1219 dbSNP
rs1487495103 1219 dbSNP
rs34460030 1219 dbSNP
rs397959241 1219 dbSNP
rs60232455 1219 dbSNP
rs1205150285 1220 dbSNP
rs1277336293 1226 dbSNP
rs1440271510 1233 dbSNP
rs1476303767 1234 dbSNP
rs1257949604 1235 dbSNP
rs1472180400 1236 dbSNP
rs1293794500 1237 dbSNP
rs1416496992 1242 dbSNP
rs1179885086 1247 dbSNP
rs1382533263 1248 dbSNP
rs223822 1254 dbSNP
rs1453998583 1255 dbSNP
rs1346591052 1258 dbSNP
rs1162241953 1270 dbSNP
rs552858868 1276 dbSNP
rs1419260202 1277 dbSNP
rs1190739579 1282 dbSNP
rs1427210044 1284 dbSNP
rs139915589 1285 dbSNP
rs1424557249 1286 dbSNP
rs187546931 1290 dbSNP
rs1433032501 1293 dbSNP
rs1271498189 1296 dbSNP
rs1213183330 1298 dbSNP
rs1335577971 1300 dbSNP
rs1315081451 1301 dbSNP
rs1324545402 1302 dbSNP
rs1294672923 1313 dbSNP
rs1376442545 1317 dbSNP
rs223823 1318 dbSNP
rs1327290345 1323 dbSNP
rs1460557536 1329 dbSNP
rs1394611903 1337 dbSNP
rs1166397668 1346 dbSNP
rs762496411 1356 dbSNP
rs1460924809 1358 dbSNP
rs1338006246 1361 dbSNP
rs1194418934 1363 dbSNP
rs1003144529 1367 dbSNP
rs1430645700 1372 dbSNP
rs1035932830 1373 dbSNP
rs1193263448 1377 dbSNP
rs1469028414 1380 dbSNP
rs1254966508 1388 dbSNP
rs1194144970 1390 dbSNP
rs191695691 1397 dbSNP
rs1273668732 1400 dbSNP
rs223824 1401 dbSNP
rs1236033723 1404 dbSNP
rs113088331 1405 dbSNP
rs1439728786 1407 dbSNP
rs1280647226 1408 dbSNP
rs1327396320 1416 dbSNP
rs1482593335 1417 dbSNP
rs1022176162 1430 dbSNP
rs968905249 1434 dbSNP
rs535448121 1443 dbSNP
rs977946455 1449 dbSNP
rs1438259926 1454 dbSNP
rs1198096657 1462 dbSNP
rs1173344850 1465 dbSNP
rs751278557 1466 dbSNP
rs1452734679 1468 dbSNP
rs1175729795 1469 dbSNP
rs1437292819 1478 dbSNP
rs1395863262 1481 dbSNP
rs183969989 1483 dbSNP
rs1251273045 1487 dbSNP
rs1031741394 1494 dbSNP
rs954720555 1495 dbSNP
rs1277938989 1499 dbSNP
rs1233272779 1505 dbSNP
rs1348229949 1507 dbSNP
rs1276215695 1509 dbSNP
rs987442266 1510 dbSNP
rs910492047 1513 dbSNP
rs943244045 1518 dbSNP
rs1166445083 1520 dbSNP
rs1393662988 1520 dbSNP
rs1399094123 1523 dbSNP
rs1435694202 1526 dbSNP
rs1397171048 1527 dbSNP
rs139702353 1533 dbSNP
rs920458542 1543 dbSNP
rs1469781334 1545 dbSNP
rs149762298 1556 dbSNP
rs1368110914 1557 dbSNP
rs557651869 1564 dbSNP
rs929153046 1565 dbSNP
rs188976305 1572 dbSNP
rs1255309112 1573 dbSNP
rs1209935412 1576 dbSNP
rs781226024 1578 dbSNP
rs1303534819 1583 dbSNP
rs750417868 1585 dbSNP
rs1280430482 1593 dbSNP
rs756205259 1595 dbSNP
rs1054677448 1601 dbSNP
rs151292920 1604 dbSNP
rs57753363 1604 dbSNP
rs1279688968 1609 dbSNP
rs1229694777 1612 dbSNP
rs894738918 1615 dbSNP
rs1293189763 1619 dbSNP
rs1415882769 1625 dbSNP
rs1339903366 1626 dbSNP
rs1316595468 1630 dbSNP
rs1400354018 1632 dbSNP
rs1385926610 1635 dbSNP
rs1209166105 1649 dbSNP
rs779983435 1655 dbSNP
rs1415642748 1658 dbSNP
rs1459909707 1658 dbSNP
rs540151675 1664 dbSNP
rs1467181099 1671 dbSNP
rs374136264 1680 dbSNP
rs999018780 1691 dbSNP
rs1190744187 1694 dbSNP
rs1446138012 1710 dbSNP
rs1284485067 1713 dbSNP
rs145699540 1720 dbSNP
rs1031772317 1728 dbSNP
rs72786863 1741 dbSNP
rs371730426 1751 dbSNP
rs563410307 1759 dbSNP
rs1017585225 1765 dbSNP
rs530890537 1766 dbSNP
rs973767943 1768 dbSNP
rs1268846180 1780 dbSNP
rs1430453923 1781 dbSNP
rs1327285528 1783 dbSNP
rs1322777921 1798 dbSNP
rs1392858026 1802 dbSNP
rs779241518 1803 dbSNP
rs1325915845 1808 dbSNP
rs1461952385 1814 dbSNP
rs1415870291 1815 dbSNP
rs1165984704 1816 dbSNP
rs1474948420 1823 dbSNP
rs1242437461 1824 dbSNP
rs867294249 1826 dbSNP
rs1466810071 1835 dbSNP
rs983220446 1839 dbSNP
rs1213756381 1844 dbSNP
rs1324094059 1847 dbSNP
rs121565 1850 dbSNP
rs1380159638 1853 dbSNP
rs1297361646 1858 dbSNP
rs1340523582 1862 dbSNP
rs1300216305 1864 dbSNP
rs767573623 1865 dbSNP
rs1439006834 1873 dbSNP
rs1370515579 1878 dbSNP
rs570949865 1879 dbSNP
rs528732169 1885 dbSNP
rs772454035 1888 dbSNP
rs946382452 1889 dbSNP
rs1336767862 1893 dbSNP
rs1170183374 1894 dbSNP
rs1394095658 1894 dbSNP
rs376775833 1894 dbSNP
rs547269329 1894 dbSNP
rs1193759723 1896 dbSNP
rs1489161578 1897 dbSNP
rs1230622541 1900 dbSNP
rs140558762 1903 dbSNP
rs1438844644 1907 dbSNP
rs569213575 1920 dbSNP
rs1063696 1921 dbSNP
rs1277292339 1922 dbSNP
rs904742843 1926 dbSNP
rs999449915 1932 dbSNP
rs535406932 1933 dbSNP
rs920304966 1934 dbSNP
rs890554711 1939 dbSNP
rs373590059 1955 dbSNP
rs1009021779 1961 dbSNP
rs1017699697 1963 dbSNP
rs965097225 1965 dbSNP
rs994836764 1966 dbSNP
rs1297616970 1972 dbSNP
rs1371316917 1972 dbSNP
rs750721247 1975 dbSNP
rs557018124 1987 dbSNP
rs1371073734 1990 dbSNP
rs950623536 1994 dbSNP
rs1187198880 1997 dbSNP
rs1432595579 1997 dbSNP
rs4784800 2003 dbSNP
rs1476444508 2006 dbSNP
rs541594277 2020 dbSNP
rs960525786 2027 dbSNP
rs990550354 2036 dbSNP
rs1387233450 2043 dbSNP
rs1176113720 2044 dbSNP
rs192464791 2045 dbSNP
rs1209244866 2046 dbSNP
rs1290250459 2056 dbSNP
rs1315293140 2058 dbSNP
rs1306457559 2069 dbSNP
rs1351073110 2072 dbSNP
rs1385148922 2091 dbSNP
rs946386380 2092 dbSNP
rs1043373020 2093 dbSNP
rs926202255 2099 dbSNP
rs774861075 2101 dbSNP
rs1467315840 2102 dbSNP
rs149014236 2104 dbSNP
rs1157787925 2112 dbSNP
rs1457293299 2133 dbSNP
rs1413471103 2134 dbSNP
rs890668832 2135 dbSNP
rs944839348 2137 dbSNP
rs658559 2139 dbSNP
rs900557047 2146 dbSNP
rs540429975 2147 dbSNP
rs555206428 2148 dbSNP
rs1260329824 2152 dbSNP
rs1216650910 2153 dbSNP
rs1210464663 2157 dbSNP
rs1271305474 2159 dbSNP
rs1231380660 2162 dbSNP
rs1354673587 2176 dbSNP
rs1313250646 2177 dbSNP
rs1408924927 2178 dbSNP
rs41466149 2187 dbSNP
rs1027621167 2188 dbSNP
rs111566579 2193 dbSNP
rs1189259754 2196 dbSNP
rs1435316056 2200 dbSNP
rs751280873 2205 dbSNP
rs1411947463 2215 dbSNP
rs1390212501 2216 dbSNP
rs1162101852 2222 dbSNP
rs1461432347 2224 dbSNP
rs1369545333 2239 dbSNP
rs1167398484 2246 dbSNP
rs1417863951 2251 dbSNP
rs1160610078 2264 dbSNP
rs544125464 2268 dbSNP
rs183599855 2269 dbSNP
rs1466366771 2270 dbSNP
rs41416644 2277 dbSNP
rs1213141697 2285 dbSNP
rs1310741924 2288 dbSNP
rs1246842810 2291 dbSNP
rs1004795336 2294 dbSNP
rs1294504475 2298 dbSNP
rs1415231145 2300 dbSNP
rs41494547 2303 dbSNP
rs375730262 2306 dbSNP
rs1323386814 2310 dbSNP
rs545980376 2324 dbSNP
rs1225423605 2325 dbSNP
rs1392139936 2326 dbSNP
rs1295824575 2330 dbSNP
rs960555001 2334 dbSNP
rs990582823 2341 dbSNP
rs1460879163 2342 dbSNP
rs761660962 2344 dbSNP
rs1372870489 2352 dbSNP
rs1169551945 2361 dbSNP
rs950374181 2368 dbSNP
rs1023822605 2375 dbSNP
rs564609618 2376 dbSNP
rs1451620499 2383 dbSNP
rs1317643887 2387 dbSNP
rs528637308 2396 dbSNP
rs1233799465 2399 dbSNP
rs187177530 2401 dbSNP
rs1452280526 2405 dbSNP
rs147729648 2407 dbSNP
rs1479585818 2411 dbSNP
rs1211968749 2414 dbSNP
rs1232662937 2419 dbSNP
rs1479918891 2422 dbSNP
rs979517442 2423 dbSNP
rs1179517054 2436 dbSNP
rs1250581557 2437 dbSNP
rs1300775163 2443 dbSNP
rs1232014300 2450 dbSNP
rs529591010 2451 dbSNP
rs1171352809 2455 dbSNP
rs1041959354 2464 dbSNP
rs1302673690 2466 dbSNP
rs1390178981 2469 dbSNP
rs223825 2472 dbSNP
rs1373980375 2477 dbSNP
rs1434953845 2481 dbSNP
rs191686907 2486 dbSNP
rs1478441141 2491 dbSNP
rs557527318 2492 dbSNP
rs1179737347 2497 dbSNP
rs912135757 2504 dbSNP
rs1352568036 2507 dbSNP
rs1250945148 2514 dbSNP
rs1444268281 2515 dbSNP
rs1483926288 2519 dbSNP
rs1277873829 2521 dbSNP
rs1199526488 2525 dbSNP
rs944870544 2528 dbSNP
rs1236246056 2531 dbSNP
rs530786381 2533 dbSNP
rs1289550209 2536 dbSNP
rs1039180254 2538 dbSNP
rs183824698 2551 dbSNP
rs900591741 2553 dbSNP
rs376864618 2554 dbSNP
rs1404618163 2560 dbSNP
rs552658690 2565 dbSNP
rs1301351656 2566 dbSNP
rs1412735576 2578 dbSNP
rs1350237127 2580 dbSNP
rs1473492376 2583 dbSNP
rs1235332901 2586 dbSNP
rs886465010 2591 dbSNP
rs1186558435 2599 dbSNP
rs1442707337 2601 dbSNP
rs1004824716 2602 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000219235.4 | 3UTR | GGCUCAGCCUCCCAAAGUGCUGGGAUUACAGGCGUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000219235.4 | 3UTR | GGCUCAGCCUCCCAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000219235.4 | 3UTR | GCUCAGCCUCCCAAAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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