pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol RPS15A   
Synonyms S15a
Description ribosomal protein S15a
Transcript NM_001019   
Other Transcripts NM_001030009   
Expression
Putative miRNA Targets on RPS15A
3'UTR of RPS15A
(miRNA target sites are highlighted)
>RPS15A|NM_001019|3'UTR
   1 GGATGTAATACATATATTTACAAATAAAATGCCTCATGGACTCTGGTGCTTCCAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31505969 35 COSMIC
COSN30188787 43 COSMIC
COSN15337707 174 COSMIC
COSN15667544 205 COSMIC
COSN22921223 348 COSMIC
COSN15337706 450 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs777949231 2 dbSNP
rs201061644 3 dbSNP
rs543810121 5 dbSNP
rs1400797893 12 dbSNP
rs781660508 15 dbSNP
rs1463941459 16 dbSNP
rs1424934317 35 dbSNP
rs1238827000 36 dbSNP
rs748007427 37 dbSNP
rs1477040281 43 dbSNP
rs781329726 44 dbSNP
rs1188430408 45 dbSNP
rs1442076202 46 dbSNP
rs768737727 47 dbSNP
rs1483411223 55 dbSNP
rs1381576606 58 dbSNP
rs1300915261 60 dbSNP
rs904945052 61 dbSNP
rs532011624 72 dbSNP
rs1479059643 75 dbSNP
rs1172018936 78 dbSNP
rs1044723646 82 dbSNP
rs56138938 83 dbSNP
rs1427726651 85 dbSNP
rs1178409928 94 dbSNP
rs949051345 99 dbSNP
rs561359874 100 dbSNP
rs1163632163 106 dbSNP
rs982936740 110 dbSNP
rs1338189242 111 dbSNP
rs1401691601 115 dbSNP
rs1046963886 116 dbSNP
rs1344289410 118 dbSNP
rs929918798 118 dbSNP
rs919768775 119 dbSNP
rs866391610 125 dbSNP
rs919009678 126 dbSNP
rs1215472102 133 dbSNP
rs1284268845 134 dbSNP
rs1425235279 135 dbSNP
rs1194920631 136 dbSNP
rs1246634665 146 dbSNP
rs911317761 152 dbSNP
rs1192974710 156 dbSNP
rs986737538 163 dbSNP
rs976175561 168 dbSNP
rs965716483 171 dbSNP
rs1180507982 175 dbSNP
rs1017258950 177 dbSNP
rs955381969 178 dbSNP
rs1318796770 181 dbSNP
rs1483089151 183 dbSNP
rs1253188410 191 dbSNP
rs1207997158 192 dbSNP
rs868834896 198 dbSNP
rs1367730930 201 dbSNP
rs1020732158 202 dbSNP
rs189416901 204 dbSNP
rs967923599 218 dbSNP
rs572597014 221 dbSNP
rs111567159 246 dbSNP
rs892570916 249 dbSNP
rs12926769 251 dbSNP
rs1350942711 252 dbSNP
rs973754073 254 dbSNP
rs1176911955 255 dbSNP
rs1309615795 256 dbSNP
rs1407963851 261 dbSNP
rs1440589703 262 dbSNP
rs1158907068 266 dbSNP
rs1403493768 267 dbSNP
rs545427048 267 dbSNP
rs905219307 268 dbSNP
rs1013782741 269 dbSNP
rs1445401260 273 dbSNP
rs1347759555 278 dbSNP
rs1283935069 280 dbSNP
rs1306506362 280 dbSNP
rs376714102 280 dbSNP
rs56008565 280 dbSNP
rs796546191 280 dbSNP
rs747155768 281 dbSNP
rs896147294 282 dbSNP
rs1047209378 285 dbSNP
rs1187143932 287 dbSNP
rs1196789539 287 dbSNP
rs1458346609 287 dbSNP
rs1419293237 289 dbSNP
rs929873352 292 dbSNP
rs556515417 293 dbSNP
rs1164850465 294 dbSNP
rs1471681079 294 dbSNP
rs898428988 297 dbSNP
rs1038136309 306 dbSNP
rs1465085543 306 dbSNP
rs942553377 308 dbSNP
rs1391544876 309 dbSNP
rs376903576 311 dbSNP
rs1045002604 316 dbSNP
rs1450625819 321 dbSNP
rs1210544767 329 dbSNP
rs941621574 330 dbSNP
rs143662298 331 dbSNP
rs1047717624 332 dbSNP
rs1221195864 340 dbSNP
rs1217359992 342 dbSNP
rs1260031118 347 dbSNP
rs1318699045 350 dbSNP
rs930141547 355 dbSNP
rs989221248 357 dbSNP
rs919029457 362 dbSNP
rs975875440 377 dbSNP
rs1257997594 379 dbSNP
rs1226289345 387 dbSNP
rs756530175 390 dbSNP
rs569915836 391 dbSNP
rs554483771 392 dbSNP
rs1282871616 393 dbSNP
rs1349825359 405 dbSNP
rs536010755 409 dbSNP
rs910226876 412 dbSNP
rs985787937 421 dbSNP
rs1364951851 422 dbSNP
rs2606564 428 dbSNP
rs1022195505 430 dbSNP
rs970201377 431 dbSNP
rs1340329248 432 dbSNP
rs988409913 436 dbSNP
rs573846529 449 dbSNP
rs550923812 450 dbSNP
rs896229440 453 dbSNP
rs1232584993 456 dbSNP
rs956577562 457 dbSNP
rs1455940179 459 dbSNP
rs1201280738 460 dbSNP
rs1280700969 460 dbSNP
rs1487848869 461 dbSNP
rs1191312337 465 dbSNP
rs1411883648 465 dbSNP
rs1200129554 466 dbSNP
rs1035241044 474 dbSNP
rs2606565 488 dbSNP
rs905250341 492 dbSNP
rs184652146 502 dbSNP
rs1360224001 503 dbSNP
rs898392923 508 dbSNP
rs1300476233 509 dbSNP
rs1386285653 513 dbSNP
rs1386730793 514 dbSNP
rs1005505715 518 dbSNP
rs888720802 520 dbSNP
rs1206591433 521 dbSNP
rs1328153411 527 dbSNP
rs375916479 528 dbSNP
rs994805019 529 dbSNP
rs1351860375 530 dbSNP
rs1214135409 535 dbSNP
rs1235419107 537 dbSNP
rs549736431 549 dbSNP
rs1028409973 550 dbSNP
rs1300057160 551 dbSNP
rs1038230579 556 dbSNP
rs942647978 560 dbSNP
rs1193781785 563 dbSNP
rs1379273056 566 dbSNP
rs889607073 570 dbSNP
rs1051408011 587 dbSNP
rs1366956800 589 dbSNP
rs1318045664 599 dbSNP
rs934050688 602 dbSNP
rs913314667 613 dbSNP
rs1330807088 615 dbSNP
rs1374920030 617 dbSNP
rs1242611833 620 dbSNP
rs531929839 621 dbSNP
rs988798969 635 dbSNP
rs1243896855 637 dbSNP
rs561600908 638 dbSNP
rs925973396 639 dbSNP
rs1213749148 652 dbSNP
rs1237056787 657 dbSNP
rs980342917 667 dbSNP
rs1178580988 670 dbSNP
rs1468072980 674 dbSNP
rs1423589848 680 dbSNP
rs369648813 680 dbSNP
rs1370668045 682 dbSNP
rs1376379371 683 dbSNP
rs970338677 684 dbSNP
rs62046276 689 dbSNP
rs1461948782 690 dbSNP
rs917385400 691 dbSNP
rs993414186 692 dbSNP
rs1450088015 696 dbSNP
rs1378792794 700 dbSNP
rs1250146500 709 dbSNP
rs1186970627 713 dbSNP
rs1464612152 715 dbSNP
rs1180453793 716 dbSNP
rs1206083240 716 dbSNP
rs1233857652 716 dbSNP
rs1256797914 716 dbSNP
rs1260074775 716 dbSNP
rs1300824571 716 dbSNP
rs1301668078 716 dbSNP
rs1310375753 716 dbSNP
rs1336795331 716 dbSNP
rs1475796215 716 dbSNP
rs1482749687 716 dbSNP
rs71141062 716 dbSNP
rs749155538 716 dbSNP
rs754258726 716 dbSNP
rs756203404 716 dbSNP
rs1338427426 718 dbSNP
rs71382565 718 dbSNP
rs957614688 720 dbSNP
rs1201945190 721 dbSNP
rs1342816974 722 dbSNP
rs1255299446 724 dbSNP
rs1273152762 726 dbSNP
rs1228503028 727 dbSNP
rs1207622140 728 dbSNP
rs960461301 742 dbSNP
rs1025830735 745 dbSNP
rs1033708569 748 dbSNP
rs1486210116 761 dbSNP
rs1193467279 762 dbSNP
rs1343608153 766 dbSNP
rs993952448 771 dbSNP
rs1227262260 777 dbSNP
rs1424589541 778 dbSNP
rs1340677823 780 dbSNP
rs549604794 781 dbSNP
rs1376359045 790 dbSNP
rs1435102944 801 dbSNP
rs1335300171 804 dbSNP
rs1358525774 816 dbSNP
rs1432830286 820 dbSNP
rs1270227133 830 dbSNP
rs527844516 831 dbSNP
rs1217053769 838 dbSNP
rs962339031 847 dbSNP
rs560655981 851 dbSNP
rs1348231681 863 dbSNP
rs1016588578 864 dbSNP
rs1312740346 882 dbSNP
rs1217139461 883 dbSNP
rs1246144069 891 dbSNP
rs1487539802 892 dbSNP
rs1006758463 894 dbSNP
rs889701866 900 dbSNP
rs1050913372 901 dbSNP
rs998440461 902 dbSNP
rs891650274 913 dbSNP
rs545564345 914 dbSNP
rs1402303982 922 dbSNP
rs1405554872 922 dbSNP
rs1392172794 925 dbSNP
rs1053600717 926 dbSNP
rs1166765907 927 dbSNP
rs1327378735 928 dbSNP
rs1475238846 929 dbSNP
rs1239016634 946 dbSNP
rs1307445489 955 dbSNP
rs1353306808 963 dbSNP
rs1289790123 973 dbSNP
rs1369224701 976 dbSNP
rs1189404225 977 dbSNP
rs1253733005 979 dbSNP
rs1457449093 986 dbSNP
rs1440414199 993 dbSNP
rs578027935 997 dbSNP
rs1158996641 1003 dbSNP
rs1412936622 1007 dbSNP
rs1459854193 1008 dbSNP
rs936105104 1019 dbSNP
rs1394584460 1026 dbSNP
rs1205859948 1031 dbSNP
rs1445507895 1032 dbSNP
rs1483976117 1033 dbSNP
rs925942487 1035 dbSNP
rs1226964342 1036 dbSNP
rs1356651916 1039 dbSNP
rs1285518729 1040 dbSNP
rs1247457449 1042 dbSNP
rs1339134593 1043 dbSNP
rs1284029109 1046 dbSNP
rs562776075 1049 dbSNP
rs1273813533 1068 dbSNP
rs1317384883 1072 dbSNP
rs1411018744 1075 dbSNP
rs948917400 1089 dbSNP
rs1306288298 1090 dbSNP
rs1409415277 1093 dbSNP
rs1391729553 1097 dbSNP
rs544558580 1100 dbSNP
rs1474147247 1104 dbSNP
rs917504778 1107 dbSNP
rs1418562423 1109 dbSNP
rs1464647120 1110 dbSNP
rs1173002679 1114 dbSNP
rs1165694811 1118 dbSNP
rs1165161098 1125 dbSNP
rs992990551 1131 dbSNP
rs950927825 1137 dbSNP
rs919460243 1139 dbSNP
rs1416982464 1142 dbSNP
rs972884666 1144 dbSNP
rs1340515845 1150 dbSNP
rs1253194291 1155 dbSNP
rs1340260611 1155 dbSNP
rs1473544332 1184 dbSNP
rs1277582991 1187 dbSNP
rs752060543 1199 dbSNP
rs1249478590 1204 dbSNP
rs1484560700 1205 dbSNP
rs576280979 1206 dbSNP
rs376998991 1207 dbSNP
rs1451618108 1215 dbSNP
rs1477484543 1216 dbSNP
rs1190339359 1217 dbSNP
rs1374332309 1219 dbSNP
rs537198112 1227 dbSNP
rs536132109 1231 dbSNP
rs953934666 1232 dbSNP
rs571957476 1245 dbSNP
rs1360422872 1246 dbSNP
rs998142295 1247 dbSNP
rs553530120 1250 dbSNP
rs1327118056 1251 dbSNP
rs4780766 1258 dbSNP
rs1232701987 1264 dbSNP
rs538390593 1274 dbSNP
rs1410863646 1275 dbSNP
rs1052996222 1279 dbSNP
rs571289230 1287 dbSNP
rs1280814071 1290 dbSNP
rs1000240616 1292 dbSNP
rs904614639 1295 dbSNP
rs1044387570 1320 dbSNP
rs1170307837 1321 dbSNP
rs948716671 1322 dbSNP
rs1197622919 1331 dbSNP
rs549535027 1347 dbSNP
rs917282760 1348 dbSNP
rs1455347074 1354 dbSNP
rs1174604405 1355 dbSNP
rs537804869 1362 dbSNP
rs1452181608 1368 dbSNP
rs567876714 1386 dbSNP
rs1386395750 1394 dbSNP
rs1386249883 1396 dbSNP
rs1324022529 1401 dbSNP
rs1373404748 1403 dbSNP
rs1235335427 1406 dbSNP
rs2650658 1407 dbSNP
rs1303784177 1412 dbSNP
rs1316129773 1413 dbSNP
rs41461745 1421 dbSNP
rs929611038 1421 dbSNP
rs1212501155 1423 dbSNP
rs527984685 1425 dbSNP
rs973545996 1427 dbSNP
rs1403859760 1433 dbSNP
rs941080990 1434 dbSNP
rs1417700432 1435 dbSNP
rs560694575 1438 dbSNP
rs1364854320 1455 dbSNP
rs1457860091 1458 dbSNP
rs1159667173 1464 dbSNP
rs1162826682 1472 dbSNP
rs551986953 1478 dbSNP
rs1441839593 1486 dbSNP
rs953700589 1488 dbSNP
rs1176606264 1489 dbSNP
rs1371540469 1493 dbSNP
rs1478312424 1500 dbSNP
rs1247988728 1514 dbSNP
rs1196107256 1515 dbSNP
rs1467772604 1516 dbSNP
rs1232636415 1519 dbSNP
rs1029363897 1534 dbSNP
rs1336325036 1537 dbSNP
rs1268327010 1538 dbSNP
rs977071477 1539 dbSNP
rs1250380376 1540 dbSNP
rs533280174 1541 dbSNP
rs1479481834 1544 dbSNP
rs1179268032 1553 dbSNP
rs1331603847 1556 dbSNP
rs955984699 1561 dbSNP
rs1475127051 1568 dbSNP
rs1186436002 1573 dbSNP
rs1266615932 1575 dbSNP
rs1223784065 1578 dbSNP
rs1462031025 1580 dbSNP
rs1346292763 1585 dbSNP
rs1031886891 1587 dbSNP
rs1434343520 1588 dbSNP
rs1000041846 1592 dbSNP
rs1299631296 1597 dbSNP
rs1373793688 1599 dbSNP
rs1414029017 1600 dbSNP
rs904582112 1605 dbSNP
rs1437530772 1614 dbSNP
rs2650657 1618 dbSNP
rs1357331779 1620 dbSNP
rs1233339065 1623 dbSNP
rs1294257903 1624 dbSNP
rs1305357317 1626 dbSNP
rs1023035273 1629 dbSNP
rs1013036381 1638 dbSNP
rs1485539331 1655 dbSNP
rs1386269064 1661 dbSNP
rs1475850106 1662 dbSNP
rs150846261 1664 dbSNP
rs1057174706 1665 dbSNP
rs1430457663 1666 dbSNP
rs1171413184 1677 dbSNP
rs1427121453 1679 dbSNP
rs1433834014 1695 dbSNP
rs1170332374 1699 dbSNP
rs1453199484 1700 dbSNP
rs1377142743 1701 dbSNP
rs1415354688 1703 dbSNP
rs929510253 1705 dbSNP
rs1359268546 1711 dbSNP
rs1215870812 1713 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agugucAACG---GUCGACUCUAAu 5'
                ||||    |||||||||| 
Target 5' ------UUGCGGUGAGCUGAGAUUg 3'
1 - 19
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000576436.1 | 3UTR | UUGCGGUGAGCUGAGAUUGUGCCAUUGCACUCCAGCCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.681 1.2e-4 0.685 1.1e-4 24 Click to see details
GSE21849 B cell lymphoma -0.422 1.1e-2 -0.391 1.8e-2 29 Click to see details
GSE28260 Renal cortex and medulla -0.577 1.9e-2 -0.375 1.0e-1 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.347 4.5e-2 -0.276 9.1e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.353 4.5e-2 0.378 3.4e-2 24 Click to see details
GSE32688 Pancreatic cancer 0.243 9.0e-2 0.225 1.1e-1 32 Click to see details
GSE38226 Liver fibrosis -0.239 1.5e-1 -0.466 1.7e-2 21 Click to see details
GSE21687 Ependynoma primary tumors 0.114 1.8e-1 -0.162 1.0e-1 64 Click to see details
GSE17306 Multiple myeloma 0.127 1.9e-1 0.518 6.9e-5 49 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.176 2.3e-1 -0.101 3.4e-1 20 Click to see details
GSE42095 Differentiated embryonic stem cells -0.152 2.4e-1 0.122 2.9e-1 23 Click to see details
GSE19350 CNS germ cell tumors 0.201 2.7e-1 0.442 7.5e-2 12 Click to see details
GSE27834 Pluripotent stem cells -0.114 3.4e-1 -0.085 3.8e-1 16 Click to see details
GSE14794 Lymphoblastoid cells -0.039 3.6e-1 -0.126 1.2e-1 90 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.002 5.0e-1 0.527 3.4e-3 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA -0.96 0.02 -0.800 0.1 4 Click to see details
PAAD -0.802 0.1 -0.400 0.3 4 Click to see details
KIRP 0.29 0.12 0.408 0.05 18 Click to see details
KICH -0.353 0.14 -0.345 0.15 11 Click to see details
STAD 0.196 0.2 0.143 0.27 20 Click to see details
LUSC 0.154 0.26 0.059 0.4 20 Click to see details
UCEC 0.216 0.27 0.248 0.24 10 Click to see details
HNSC 0.125 0.28 0.150 0.25 23 Click to see details
THCA -0.079 0.3 -0.060 0.34 47 Click to see details
PRAD 0.076 0.34 -0.010 0.48 31 Click to see details
BLCA -0.123 0.37 -0.127 0.36 10 Click to see details
LIHC -0.046 0.38 -0.040 0.4 45 Click to see details
LUAD -0.031 0.47 0.100 0.4 9 Click to see details
BRCA 0.016 0.47 0.118 0.29 25 Click to see details
CHOL -0.013 0.49 0.143 0.37 8 Click to see details
KIRC 0.003 0.49 0.124 0.26 29 Click to see details
KIRC 0.003 0.49 0.124 0.26 29 Click to see details
KIRC 0.003 0.49 0.124 0.26 29 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

Error report submission