pre-miRNA Information
pre-miRNA hsa-mir-4316   
Genomic Coordinates chr17: 77396984 - 77397054
Description Homo sapiens miR-4316 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4316
Sequence 11| GGUGAGGCUAGCUGGUG |27
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs989002279 5 dbSNP
rs957742923 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol EIF2S3   
Synonyms EIF2, EIF2G, EIF2gamma, MRXSBRK, eIF-2gA
Description eukaryotic translation initiation factor 2 subunit gamma
Transcript NM_001415   
Expression
Putative miRNA Targets on EIF2S3
3'UTR of EIF2S3
(miRNA target sites are highlighted)
>EIF2S3|NM_001415|3'UTR
   1 AGAATACCAGTTAAATAATACATTCGGATGGATTTGGAAGTTGGAATTCCTCTTAACAACCAAGGGGTTTATTTTCAAAG
  81 CAATATTGGGGAATTGATTTCACAGTTCGTTACCTTAGTAGGTAACGGTAAGGTTATTCTCTTTTTTTTTTTTTTTTTTT
 161 TTGGTTATGAAAACTTAGGGACTAAAATTAATATAAAAATTGGCATAATGTTGGATTGAATCTACATTTTGGCAGAAGTT
 241 AAACATTCCCACATAATGTCAAAATTATACATCATGCAGTTCTGTTTTTTTGTTTGTTTTATTTTGTTTTGTTTTTGAGT
 321 CTGGCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTGCAACCTCTGCCCCCCGGGTTCAAGCGATTCTCCTGCCTC
 401 AGCCTCCCGAGTAGCTGAGATTACAGGTGCGCGCCACCACACTTGGCTAATTTTTGTATTATTAGTAGAGACGGGGTTTC
 481 AGCATGTTGGCTAGGCCGGTCTCTCCTGACCTCAGGGTGATCAGCCCACCTCGGCCTCACAAAGTGCTGGGATTACAGGC
 561 GTGAGCCACCTTGCCCAGCCCACATCATACAGTTTGAAATGAAACTTTGCCACAACCAGCCTTTGCTGTAGCACACACAT
 641 ATATCACTGAACCTGTTTGAAATAAAGTTTTTTTTCTTTTTCATGATTCGTCTTTGAGTACCTCCAGGCTGAAAGACTGT
 721 TGTACCAGTAAAAACTTAAAGGCACAAATTCTCCTTGAAGACCTTCTCCCTTTTATGTGGCCCCATATTTTATGTTGCTT
 801 TATCTTTGAAATTTTGCATGAAAAGGAAATGAATGGATTCGAATGAAATTGTCCTTTAGAGCATGATTACTTGTTCCCAT
 881 GGACAAATATTTTTCTCCCCTTGCTCTTCCTGGCCTGAAACACGGGAAACCAGAGTCAAAAGTTATCTCCCTCTCCCTGT
 961 GATGCCTTGAGATTTTTTTCTGCGTTGTTTAATGCCTGAAATCCAAGTCTTCCTCCATGGGAAAATACTGTTATACCAAA
1041 TAATTCTAGATGAGTAACAAAGATCTTTTTAGGCCTTCATTTTATGTTTTTTCTTAACTGTTATATTATGATTGTGACAT
1121 AGATTATACTACTACTAATTTTTGGATGTTTCAAAAGGTCAAGAAGTAAAAGATGTTAGAAAGCAATGAGTGAGTCCTTT
1201 TGATTTTTAACTTATTCCCCATGTCCCTATACTTCGTGTGCTTTTCCTTTTTTTTTTTGAGACGGAGGCTCACTCCGTCA
1281 CCTAGGCTAGAGTACAGTGGCACGATCTTGGCTCGCTGCAACCTCTGCCTCCCTGATTCAAGTGATTCTCGTGCTTCAGC
1361 CTCCCATGTAGCTGATATTACAGGCACTTGCCACCATACCCGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCACC
1441 ATGTTGCCCAGGCTGGTCTTGAACTCCTAACCTCAGGTGATCCGCCCGCCTCTGCCTTCCAAAGTGCTGGGATTACAGGC
1521 GTGAGCCACTCTGCCCGGCTTATTTTTCTTTATGTTTTTGCTTCGTAAGAGGTTCTGTTGAGCAGTGATTTGCAACTCTT
1601 GCTGACGTTGCTGGGGAAGCTTTAAAAAAAAAAAAGATGCCCCACAGAGATTCTGATTTTAATTGTTCTGATTTAATTGG
1681 CTTGGAGTAGAATTCAGGCATTGATATCTTTAAAAACTCCCCAGTGTTGAGAAACAAATTTAGAGAGTTGAGAAGTAGGT
1761 ATATTAAATTACAGAATCTTACTGAGTTTTGGTAGACTGATAATACAATTTGCTTTGCTTTTCTTAAATTTGCATTGAGA
1841 TGGGATTTGAAGCATATTGTGCTCTTGTGAATGTTGAAGTTGCATTGTAGAAGTTTAGAAGCTCTGGCTATGGGTTGCCT
1921 AAATTGATGTTTTGAGGAAGCATATTAATGTTATAAACTTCGCTGACTTTGAAGGTTGTGTTGTAGCATGAGGAACACAA
2001 ATAAAACAATTCTAAATCAAACTAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guGGUCGA-UCGGAGUGg 5'
            ||| || :||||||| 
Target 5' gcCCACCTCGGCCTCACa 3'
524 - 541 155.00 -17.60
2
miRNA  3' guggucGAUCGGAGUgg 5'
                || ||||||  
Target 5' attctcCT-GCCTCAgc 3'
388 - 403 122.00 -11.70
3
miRNA  3' gugguCGA--UCGGAGUGg 5'
               |||  |||||| | 
Target 5' ctcgtGCTTCAGCCTCCCa 3'
1348 - 1366 118.00 -15.30
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773796835 7 dbSNP
rs749718018 14 dbSNP
rs1246106249 23 dbSNP
rs1466144042 24 dbSNP
rs1284964911 25 dbSNP
rs369749610 26 dbSNP
rs1242265121 27 dbSNP
rs771163509 37 dbSNP
rs776241535 43 dbSNP
rs1368600750 53 dbSNP
rs761773962 59 dbSNP
rs1332120579 61 dbSNP
rs111630683 84 dbSNP
rs1469285068 85 dbSNP
rs1389178273 86 dbSNP
rs1012096463 87 dbSNP
rs111372663 109 dbSNP
rs1236761845 127 dbSNP
rs1419609574 128 dbSNP
rs191563492 134 dbSNP
rs1182097205 137 dbSNP
rs199708557 138 dbSNP
rs372625244 139 dbSNP
rs762440475 139 dbSNP
rs1209395867 140 dbSNP
rs1230580744 140 dbSNP
rs1271987474 140 dbSNP
rs1290879026 140 dbSNP
rs1293619037 140 dbSNP
rs1323808715 140 dbSNP
rs1351341333 140 dbSNP
rs1354416948 140 dbSNP
rs1365797552 140 dbSNP
rs1401264495 140 dbSNP
rs1432657141 140 dbSNP
rs747088489 140 dbSNP
rs376888206 141 dbSNP
rs1167335026 142 dbSNP
rs1225992450 142 dbSNP
rs1275201860 142 dbSNP
rs1309420361 142 dbSNP
rs1329029211 142 dbSNP
rs1369329118 142 dbSNP
rs1369543346 142 dbSNP
rs1388015465 142 dbSNP
rs1416643297 142 dbSNP
rs1429845927 142 dbSNP
rs1435366723 142 dbSNP
rs5949273 142 dbSNP
rs879230822 142 dbSNP
rs1426372221 144 dbSNP
rs1190945241 145 dbSNP
rs1166426545 161 dbSNP
rs1234835856 163 dbSNP
rs1477220455 163 dbSNP
rs754534322 163 dbSNP
rs1394516373 164 dbSNP
rs1386262070 165 dbSNP
rs5949274 166 dbSNP
rs900330663 168 dbSNP
rs1329141651 169 dbSNP
rs1375273518 170 dbSNP
rs764546995 171 dbSNP
rs1391750919 175 dbSNP
rs1313855138 176 dbSNP
rs1279198665 180 dbSNP
rs1218454786 199 dbSNP
rs1342546504 203 dbSNP
rs747020844 206 dbSNP
rs1340066979 216 dbSNP
rs1349400994 233 dbSNP
rs1305619807 248 dbSNP
rs1450862926 254 dbSNP
rs755285963 269 dbSNP
rs1360280324 283 dbSNP
rs1175914194 286 dbSNP
rs1413132709 287 dbSNP
rs754187586 289 dbSNP
rs1231579216 293 dbSNP
rs1295222170 297 dbSNP
rs905941576 297 dbSNP
rs146275076 301 dbSNP
rs779548178 312 dbSNP
rs1409905249 313 dbSNP
rs1198572182 325 dbSNP
rs1003391589 332 dbSNP
rs1238001289 335 dbSNP
rs1250064959 354 dbSNP
rs1209257363 355 dbSNP
rs746010027 365 dbSNP
rs1196739600 371 dbSNP
rs1255092947 375 dbSNP
rs183853883 377 dbSNP
rs112482955 378 dbSNP
rs1379186500 384 dbSNP
rs796118641 387 dbSNP
rs111579157 388 dbSNP
rs1477176898 409 dbSNP
rs1457011812 410 dbSNP
rs1410068194 420 dbSNP
rs3207873 424 dbSNP
rs781513490 431 dbSNP
rs748355601 432 dbSNP
rs1356206711 433 dbSNP
rs1462346340 434 dbSNP
rs1016472778 457 dbSNP
rs1249706276 457 dbSNP
rs769666674 473 dbSNP
rs747279131 474 dbSNP
rs1265863628 477 dbSNP
rs1223225739 482 dbSNP
rs375249551 486 dbSNP
rs1311367463 498 dbSNP
rs1227153109 499 dbSNP
rs1413197882 518 dbSNP
rs1368016672 529 dbSNP
rs1295278157 531 dbSNP
rs974879790 533 dbSNP
rs1434849534 534 dbSNP
rs922129214 540 dbSNP
rs1295578573 549 dbSNP
rs1458592680 553 dbSNP
rs1349423621 561 dbSNP
rs768724793 566 dbSNP
rs772875198 570 dbSNP
rs954473303 576 dbSNP
rs1391970843 584 dbSNP
rs749304872 585 dbSNP
rs1228674533 591 dbSNP
rs923608421 593 dbSNP
rs3207877 613 dbSNP
rs1259389405 614 dbSNP
rs934996622 626 dbSNP
rs1255804151 627 dbSNP
rs1264389796 635 dbSNP
rs1053671498 636 dbSNP
rs1484857345 642 dbSNP
rs1343610520 644 dbSNP
rs1275986323 653 dbSNP
rs570029856 660 dbSNP
rs1363538680 668 dbSNP
rs1303832306 671 dbSNP
rs114095209 677 dbSNP
rs1367210277 691 dbSNP
rs947988877 698 dbSNP
rs1291952281 705 dbSNP
rs1257766181 710 dbSNP
rs1487716246 711 dbSNP
rs1044901008 716 dbSNP
rs1184227680 726 dbSNP
rs1169217032 739 dbSNP
rs1421632011 754 dbSNP
rs1429066938 763 dbSNP
rs1177927385 765 dbSNP
rs1433508297 766 dbSNP
rs34373297 771 dbSNP
rs17217346 781 dbSNP
rs1196757951 793 dbSNP
rs906386831 804 dbSNP
rs773914313 808 dbSNP
rs1436286197 812 dbSNP
rs73626807 826 dbSNP
rs1337983273 837 dbSNP
rs1376285359 842 dbSNP
rs1234445068 843 dbSNP
rs1311915055 861 dbSNP
rs1281617929 862 dbSNP
rs1411892847 864 dbSNP
rs1351241922 876 dbSNP
rs1307470397 879 dbSNP
rs1399519715 890 dbSNP
rs773100426 891 dbSNP
rs1287168103 898 dbSNP
rs369824654 901 dbSNP
rs1364123042 910 dbSNP
rs1409174902 924 dbSNP
rs111365706 925 dbSNP
rs1002930205 934 dbSNP
rs373279652 936 dbSNP
rs1466367632 942 dbSNP
rs1346240824 943 dbSNP
rs1376855977 950 dbSNP
rs1057466974 951 dbSNP
rs1473356631 952 dbSNP
rs886403120 955 dbSNP
rs5990022 958 dbSNP
rs1280651947 961 dbSNP
rs1258888671 973 dbSNP
rs1342519226 984 dbSNP
rs1201458520 985 dbSNP
rs1483166346 985 dbSNP
rs1261645682 995 dbSNP
rs1230513328 1004 dbSNP
rs1004847506 1008 dbSNP
rs1287917658 1015 dbSNP
rs1352506294 1035 dbSNP
rs1342276151 1041 dbSNP
rs1314852841 1043 dbSNP
rs1396526484 1066 dbSNP
rs759230168 1066 dbSNP
rs1401294331 1075 dbSNP
rs767019726 1099 dbSNP
rs554809635 1101 dbSNP
rs1388950085 1104 dbSNP
rs775164804 1105 dbSNP
rs1213156622 1106 dbSNP
rs1468158474 1112 dbSNP
rs1369688654 1115 dbSNP
rs1188921069 1119 dbSNP
rs1016259343 1120 dbSNP
rs1243373088 1122 dbSNP
rs1241722441 1124 dbSNP
rs899406195 1127 dbSNP
rs1211002940 1131 dbSNP
rs1465588019 1134 dbSNP
rs1485867854 1138 dbSNP
rs1203614025 1146 dbSNP
rs754310279 1161 dbSNP
rs760316459 1169 dbSNP
rs996413792 1174 dbSNP
rs1251042981 1187 dbSNP
rs1029089110 1203 dbSNP
rs757690866 1207 dbSNP
rs1395971817 1212 dbSNP
rs73626808 1219 dbSNP
rs1365567969 1221 dbSNP
rs765692976 1230 dbSNP
rs1317279861 1232 dbSNP
rs1398579534 1233 dbSNP
rs750946562 1235 dbSNP
rs1392316981 1236 dbSNP
rs1163297275 1239 dbSNP
rs1190994172 1248 dbSNP
rs748940396 1248 dbSNP
rs955065747 1248 dbSNP
rs1347053215 1249 dbSNP
rs1191368812 1253 dbSNP
rs1431556918 1260 dbSNP
rs1290813907 1265 dbSNP
rs1209343348 1266 dbSNP
rs548443882 1272 dbSNP
rs1289507418 1274 dbSNP
rs547123775 1277 dbSNP
rs755245748 1278 dbSNP
rs1269356001 1289 dbSNP
rs1428258331 1291 dbSNP
rs750699468 1295 dbSNP
rs1332488934 1304 dbSNP
rs1323749509 1315 dbSNP
rs758953483 1316 dbSNP
rs5949219 1319 dbSNP
rs1143263 1324 dbSNP
rs1389994331 1330 dbSNP
rs989141936 1339 dbSNP
rs1479182441 1340 dbSNP
rs751714842 1354 dbSNP
rs914932158 1365 dbSNP
rs1489898757 1367 dbSNP
rs947937933 1368 dbSNP
rs1207268769 1376 dbSNP
rs980694694 1382 dbSNP
rs1317045842 1384 dbSNP
rs748006785 1386 dbSNP
rs1271237824 1387 dbSNP
rs927794624 1392 dbSNP
rs1469746644 1398 dbSNP
rs1194130070 1402 dbSNP
rs769550938 1403 dbSNP
rs939183367 1409 dbSNP
rs1222511082 1411 dbSNP
rs772939344 1422 dbSNP
rs368898207 1423 dbSNP
rs1354490660 1434 dbSNP
rs1327372623 1438 dbSNP
rs770703518 1439 dbSNP
rs1175763122 1442 dbSNP
rs940802458 1448 dbSNP
rs1410435050 1457 dbSNP
rs1037654609 1464 dbSNP
rs1164278160 1468 dbSNP
rs1414332623 1468 dbSNP
rs1183020463 1472 dbSNP
rs1392320983 1476 dbSNP
rs1463506923 1484 dbSNP
rs1223435424 1485 dbSNP
rs899185377 1488 dbSNP
rs1327082062 1489 dbSNP
rs773924394 1505 dbSNP
rs996362954 1510 dbSNP
rs1029663579 1518 dbSNP
rs890597491 1521 dbSNP
rs1440450048 1522 dbSNP
rs1202687405 1529 dbSNP
rs758955981 1543 dbSNP
rs184593345 1544 dbSNP
rs1321015647 1545 dbSNP
rs1373567071 1551 dbSNP
rs1228486289 1565 dbSNP
rs539509978 1566 dbSNP
rs775251721 1568 dbSNP
rs1031207075 1572 dbSNP
rs956639049 1572 dbSNP
rs1360157107 1576 dbSNP
rs1336241454 1592 dbSNP
rs762318972 1601 dbSNP
rs1468528733 1603 dbSNP
rs1226042067 1606 dbSNP
rs1214260302 1607 dbSNP
rs1257331424 1608 dbSNP
rs373127191 1617 dbSNP
rs1175463356 1624 dbSNP
rs1266765067 1624 dbSNP
rs1405875681 1624 dbSNP
rs989256175 1625 dbSNP
rs1202821171 1635 dbSNP
rs1459768879 1636 dbSNP
rs1269633658 1652 dbSNP
rs1208962648 1666 dbSNP
rs1315871108 1673 dbSNP
rs1281496105 1691 dbSNP
rs755153516 1698 dbSNP
rs1234865939 1705 dbSNP
rs1450926876 1712 dbSNP
rs1470649304 1715 dbSNP
rs1321544854 1726 dbSNP
rs1453297974 1732 dbSNP
rs969060745 1746 dbSNP
rs1167043643 1748 dbSNP
rs1415780465 1751 dbSNP
rs1385806067 1762 dbSNP
rs1182844554 1776 dbSNP
rs980643723 1777 dbSNP
rs1476192130 1781 dbSNP
rs927878640 1783 dbSNP
rs1485321144 1808 dbSNP
rs1239960571 1809 dbSNP
rs939316474 1814 dbSNP
rs140754709 1815 dbSNP
rs1396399033 1818 dbSNP
rs1408611550 1823 dbSNP
rs1244416398 1833 dbSNP
rs1331263873 1860 dbSNP
rs908400426 1865 dbSNP
rs1381972121 1868 dbSNP
rs1360162580 1873 dbSNP
rs34323788 1884 dbSNP
rs1355429284 1885 dbSNP
rs1437291429 1901 dbSNP
rs1365035593 1906 dbSNP
rs940751588 1911 dbSNP
rs190407199 1920 dbSNP
rs763524866 1921 dbSNP
rs1170915806 1941 dbSNP
rs931993635 1955 dbSNP
rs1233360434 1962 dbSNP
rs1192501864 1963 dbSNP
rs781385103 1968 dbSNP
rs1490389384 1987 dbSNP
rs1129148 1998 dbSNP
rs1267538844 2003 dbSNP
rs1337346361 2003 dbSNP
rs1216210176 2013 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903829
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_a
Location of target site NM_001415 | 3UTR | CUCGGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903830
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / CTLTD_shCTL_b
Location of target site NM_001415 | 3UTR | CGGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903832
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_b
Location of target site NM_001415 | 3UTR | ACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001415 | 3UTR | CACCCAGGCUGGAGUGCAGUGGCGUGAUCUGCAACCUCUGCCCCCCGGGUUCAAGCGAUUCUCCUGCCUCAGCCUCCCGAGUAGCUGAGAUUACAGGUGCGCGCCACCACACUUGGCUAAUUUUUGUAUUAUUAGUAGAGACGGGGUUUCAGCAUGUUGGCUAGGCCGGUCUCUCCUGACCUCAGGGUGAUCAGCCCACCUCGGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001415 | 3UTR | CCCACCUCGGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001415 | 3UTR | CACCCAGGCUGGAGUGCAGUGGCGUGAUCUGCAACCUCUGCCCCCCGGGUUCAAGCGAUUCUCCUGCCUCAGCCUCCCGAGUAGCUGAGAUUACAGGUGCGCGCCACCACACUUGGCUAAUUUUUGUAUUAUUAGUAGAGACGGGGUUUCAGCAUGUUGGCUAGGCCGGUCUCUCCUGACCUCAGGGUGAUCAGCCCACCUCGGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001415 | 3UTR | CCUCGGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001415 | 3UTR | GGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001415 | 3UTR | CGGCCUCACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000253039.4 | 3UTR | ACAAAGUGCUGGGAUUACAGGCGUGAGCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000253039.4 | 3UTR | ACAAAGUGCUGGGAUUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000253039.4 | 3UTR | CACAAAGUGCUGGGAUUACAGGCGUGAGCCACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
74 hsa-miR-4316 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080624 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT095088 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT123331 CALU calumenin 2 2
MIRT154964 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT370850 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT442955 SGCD sarcoglycan delta 2 2
MIRT448240 ZNF774 zinc finger protein 774 2 2
MIRT451710 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT452072 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT455665 GLO1 glyoxalase I 2 2
MIRT460354 TXNDC16 thioredoxin domain containing 16 2 2
MIRT461908 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462047 HOXC13 homeobox C13 2 2
MIRT462735 EFNB1 ephrin B1 2 2
MIRT463409 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464952 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT465052 TSR1 TSR1, ribosome maturation factor 2 2
MIRT467549 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 4
MIRT470226 PRRC2A proline rich coiled-coil 2A 2 2
MIRT474081 LMBR1L limb development membrane protein 1 like 2 2
MIRT474481 KLHDC8B kelch domain containing 8B 2 2
MIRT474704 KIF3A kinesin family member 3A 2 2
MIRT474897 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475203 IL2RB interleukin 2 receptor subunit beta 2 2
MIRT477664 EFHD2 EF-hand domain family member D2 2 2
MIRT477775 E2F3 E2F transcription factor 3 2 2
MIRT477940 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478224 DDX52 DExD-box helicase 52 2 2
MIRT479904 CCDC117 coiled-coil domain containing 117 2 2
MIRT480639 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT482435 ADM adrenomedullin 2 10
MIRT483908 GNB1L G protein subunit beta 1 like 2 2
MIRT484161 FAM71B family with sequence similarity 71 member B 2 2
MIRT484405 SNX19 sorting nexin 19 2 2
MIRT485426 LASP1 LIM and SH3 protein 1 2 2
MIRT489788 KRT80 keratin 80 2 4
MIRT490813 ASB1 ankyrin repeat and SOCS box containing 1 2 4
MIRT491176 LAMA5 laminin subunit alpha 5 2 2
MIRT491573 HSDL1 hydroxysteroid dehydrogenase like 1 2 2
MIRT492633 PLXNA1 plexin A1 2 2
MIRT492984 NAV1 neuron navigator 1 2 2
MIRT496441 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501829 NCOA3 nuclear receptor coactivator 3 2 2
MIRT502165 KIAA0195 transmembrane protein 94 2 2
MIRT508652 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT509554 ACTG1 actin gamma 1 2 4
MIRT520033 YOD1 YOD1 deubiquitinase 2 6
MIRT523969 DVL3 dishevelled segment polarity protein 3 2 2
MIRT526150 KIAA1456 KIAA1456 2 2
MIRT530330 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT539985 SLC24A4 solute carrier family 24 member 4 2 4
MIRT540851 NUP155 nucleoporin 155 2 2
MIRT542326 LIMD1 LIM domains containing 1 2 2
MIRT558908 CBX5 chromobox 5 2 2
MIRT563663 SMC4 structural maintenance of chromosomes 4 2 2
MIRT565433 SURF4 surfeit 4 2 2
MIRT567773 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT615573 NCS1 neuronal calcium sensor 1 2 2
MIRT627336 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT632965 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT634307 SNTN sentan, cilia apical structure protein 2 2
MIRT641569 RAX retina and anterior neural fold homeobox 2 2
MIRT660509 ARL5A ADP ribosylation factor like GTPase 5A 2 2
MIRT662703 C10orf111 chromosome 10 open reading frame 111 2 4
MIRT663214 ZNF277 zinc finger protein 277 2 2
MIRT665318 YIPF4 Yip1 domain family member 4 2 2
MIRT695264 CD209 CD209 molecule 2 2
MIRT696231 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT698867 SRPR SRP receptor alpha subunit 2 2
MIRT702700 IPO9 importin 9 2 2
MIRT704236 DHDDS dehydrodolichyl diphosphate synthase subunit 2 2
MIRT704935 CCDC120 coiled-coil domain containing 120 2 2
MIRT724285 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT735579 VEGFA vascular endothelial growth factor A 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4316 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-miR-4316 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4316 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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