pre-miRNA Information
pre-miRNA hsa-mir-6501   
Genomic Coordinates chr21: 33550662 - 33550728
Description Homo sapiens miR-6501 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6501-5p
Sequence 3| AGUUGCCAGGGCUGCCUUUGGU |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
1055619 20 ClinVar
COSM5974214 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs756127353 5 dbSNP
rs764400023 6 dbSNP
rs753967693 8 dbSNP
rs1283296362 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DUSP18   
Synonyms DSP18, DUSP20, LMWDSP20
Description dual specificity phosphatase 18
Transcript NM_152511   
Expression
Putative miRNA Targets on DUSP18
3'UTR of DUSP18
(miRNA target sites are highlighted)
>DUSP18|NM_152511|3'UTR
   1 GCCATCCCACGAGCCCCTGCATTGGAGTCAGAGGTACAGATCTATTGTTGATCTTACACCAAGATCCAAACTTGAACATT
  81 CTACTTTTGTTGATACAGAAAAAAACAGATGATGCCTTTTATGAGCACAAAAAAGAGTTGCTGTAGCTTTTAACTTTATA
 161 ATCCATTTTTTTTAAGATTAAACTAATTGTGAGATGGTGAAGATAAATTTTCTGCCCTGTGAGTGACACTGGCCAGGGGA
 241 TAGGTTGAGGCAGATGGTGCCCAGAAGAAAGAGGGCAGCACCCATTGCACATGGCAGGCCTGGAATCCTGCAGCCCTCCC
 321 CAAAAACAGATTGACCCAGGAATGAATCTGCTACAATTCCACCTCATTCTTTCACACCCAGAGCCAGAGCCTTAAGCATC
 401 ATGGTACCTCTTGCGCTTCTTACAGTGAGTGCCAATCTACTAGATAAATGGCCTTCAGGCAGTGCTCCAGGAATCCTGGG
 481 GGGTCCCAGGCCACCTCTGCTTCCACCTTCACTATAAGTGGCCCAGTTCTGGTTTTCTAGATTGTACTTATGCATAAGAT
 561 AGTTTTTAAAGAAAGCATTCCACTGTGTAAATTTTTTTTTGTCTTTTTTTGAAACTGTCCTGCTCTGTCACCCATCCTAG
 641 AGTGCAGTAGTGTGATCATGGCTCACTGTAGCCACAACCTCTCAGGCTCAAGTGATCCTCTTACCTTAGCCTCCTGCGTG
 721 GCTGGGACTACAGATGTTTGCCACCATGCCCGCCTCATTTTTTTTCTTTTTTTATAGAGATGAGATTTTACTATGTCGCC
 801 CAGACTGGTCTCAAACTCCTGGCCTCAAGCAATCCTCACGCCTCAGCCTCCCAAAGTGTTGATGAGCCACTGTACCCCGA
 881 TACCACTGTATAAAAAATTTAAAAAAAATTGTGAGTGCTATTGTACATGGCAAAGTTTCAAAGAGCTCTTGGCCATCCCT
 961 CACCAAACTTTGGCAAAAGATGGTGTTAGTCCCCTTCTCCAGGGCACATGAGAAAAACAGGCCTAACATCAGGTCTCAGC
1041 GGTTCCTCTCACAGGCCTTGGCTTGGAAGGCTGGAGCTTCGGACCAAGGCCCAGCCCTGTCACCTCCTCTTCATGTGATG
1121 TGGACCCCTGGGAGCATCAGTGTCCTCATCTGTCCAATGACAGCCCTTTTCTCACAGAGTTATTGTGAAGATTCAACAAT
1201 TTCTTGGCATAGTGCCTGGCACATGGTGTGTGCTTAGCGCAAATGGCAGCTCTCATCATGAATGATAGACTCTTTCACCC
1281 TGCTGGTCCCAGGTCGGCACACACATCCCCATAATGGCATTTCTCCTTTCTGTGCACAGCACTTTATTGTTACAAAGTAC
1361 TCTTCCAAAAAGTTACCCTGTGTGTAAAAAAAAAAAAAAAAAAAAATGGTTTAAGTCCTTTCAGACCCTACCTCACAGGA
1441 GGCCTAGACTTAGAGCCTTTTGAGAGCTTCCGTCTTGTTTAATCTAGGTGCAATCTAGAGGTCCTGAAACAAGGAGCACA
1521 GTTCCAGCTTCCCCCAATCACTTCTAAACAGTGACTGCAGCCTTGTTTAGAATCACTATGAAAACCTGCACCCCGGCTGA
1601 CTACTGGGATCCATAAGGGGGCCGTGTCAAAGGGACTAACTAGTGGACTCCATCAGTAGGCCCTGGAATTCAGGATTGTT
1681 CACATCCTCTTGGTGCCAAGGACCTGGCTGAAGACCAGCTCTTCTGATCCAGAGGTTTTCAGCAAACAGCATTTGAAACA
1761 AAAGCACAGCTGCTCTGTTTGACACCAAACTGTGGCTCCAGATTCCAGTAGAAGCCAAATGCTTTTTCTTTTAACAGCTG
1841 GGTGCCTGTAATCCCAGTTACTTGGGAGGCTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCG
1921 AGCTTGCACCATTGCACTCCAGCCTGGGCAACAAGAGTGAGACTCCATCTCAAAAAGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugguuuccGUCGGGACCGUUGa 5'
                  |||||: |||||| 
Target 5' ttgcactcCAGCCTGGGCAACa 3'
1932 - 1953 134.00 -18.50
2
miRNA  3' ugGUUUCCGUCGGGACCGUUga 5'
            ||||     |::||||||  
Target 5' acCAAA-----CTTTGGCAAaa 3'
962 - 978 131.00 -13.80
3
miRNA  3' ugguuuccGUCGGG---ACCGUUGa 5'
                  :||| |   |||||:| 
Target 5' tgtgtgctTAGCGCAAATGGCAGCt 3'
1227 - 1251 130.00 -14.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13910233 10 COSMIC
COSN30525344 45 COSMIC
COSN30459143 67 COSMIC
COSN508005 98 COSMIC
COSN31503614 110 COSMIC
COSN31580107 162 COSMIC
COSN30676681 166 COSMIC
COSN24381060 173 COSMIC
COSN24297153 174 COSMIC
COSN28744376 174 COSMIC
COSN22687368 240 COSMIC
COSN22232250 454 COSMIC
COSN1260785 1492 COSMIC
COSN20661743 1715 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1243126083 1 dbSNP
rs780536202 4 dbSNP
rs1450102425 7 dbSNP
rs1292051248 8 dbSNP
rs756496468 9 dbSNP
rs371630116 10 dbSNP
rs1011008862 11 dbSNP
rs893879557 13 dbSNP
rs1230588462 17 dbSNP
rs1362394249 18 dbSNP
rs1052420769 21 dbSNP
rs1348072779 21 dbSNP
rs777330023 22 dbSNP
rs1433781963 27 dbSNP
rs1351287772 28 dbSNP
rs758100559 33 dbSNP
rs1428513952 36 dbSNP
rs1368232215 37 dbSNP
rs893125735 39 dbSNP
rs58619343 42 dbSNP
rs78592960 44 dbSNP
rs373502013 45 dbSNP
rs759046552 50 dbSNP
rs759310828 51 dbSNP
rs1045851006 53 dbSNP
rs1362188246 60 dbSNP
rs948975045 77 dbSNP
rs916130083 78 dbSNP
rs1413135500 87 dbSNP
rs1038581128 104 dbSNP
rs111803206 106 dbSNP
rs571380555 106 dbSNP
rs941743916 106 dbSNP
rs532504807 109 dbSNP
rs1263806179 112 dbSNP
rs1046320552 117 dbSNP
rs1333548710 124 dbSNP
rs1440932454 130 dbSNP
rs1279780622 135 dbSNP
rs1425047565 138 dbSNP
rs947939011 143 dbSNP
rs1279394958 144 dbSNP
rs983234091 144 dbSNP
rs1348481510 154 dbSNP
rs1213012466 157 dbSNP
rs1248504133 158 dbSNP
rs747420326 164 dbSNP
rs552648980 165 dbSNP
rs182765470 166 dbSNP
rs1048687783 173 dbSNP
rs2240002 174 dbSNP
rs923133666 174 dbSNP
rs1253650364 175 dbSNP
rs1396125575 187 dbSNP
rs1220002455 189 dbSNP
rs1490149295 209 dbSNP
rs1393615202 212 dbSNP
rs918331297 219 dbSNP
rs1292412845 220 dbSNP
rs1223761339 229 dbSNP
rs1337132867 231 dbSNP
rs529976634 232 dbSNP
rs1438325300 233 dbSNP
rs560958490 237 dbSNP
rs1306449445 238 dbSNP
rs1249559935 239 dbSNP
rs1338774591 240 dbSNP
rs1017575210 244 dbSNP
rs1224512594 250 dbSNP
rs561956840 251 dbSNP
rs1275262067 265 dbSNP
rs1467299609 271 dbSNP
rs1193311360 276 dbSNP
rs1253949672 279 dbSNP
rs1375839709 281 dbSNP
rs370093997 282 dbSNP
rs1191599289 288 dbSNP
rs1373037708 291 dbSNP
rs1404738808 303 dbSNP
rs191779581 310 dbSNP
rs912178934 312 dbSNP
rs987753570 316 dbSNP
rs1476049040 326 dbSNP
rs1167970564 336 dbSNP
rs1401923953 337 dbSNP
rs1459548788 354 dbSNP
rs1346624752 363 dbSNP
rs1324813574 369 dbSNP
rs1394873783 374 dbSNP
rs953733455 377 dbSNP
rs1293306127 397 dbSNP
rs1325759961 399 dbSNP
rs1228136183 406 dbSNP
rs1271996083 408 dbSNP
rs1332771814 414 dbSNP
rs1029184535 415 dbSNP
rs1452314440 423 dbSNP
rs989600900 425 dbSNP
rs527431568 435 dbSNP
rs1470072235 442 dbSNP
rs377191360 448 dbSNP
rs1261536101 449 dbSNP
rs998966511 455 dbSNP
rs907241080 467 dbSNP
rs1400874057 479 dbSNP
rs564589791 482 dbSNP
rs1473947622 483 dbSNP
rs1013072246 484 dbSNP
rs1163699836 484 dbSNP
rs1459161014 485 dbSNP
rs1196934705 493 dbSNP
rs894644226 514 dbSNP
rs1382645575 524 dbSNP
rs544614555 526 dbSNP
rs1358725086 527 dbSNP
rs1353586449 532 dbSNP
rs1479984300 533 dbSNP
rs1187045833 541 dbSNP
rs999534508 544 dbSNP
rs1337194613 552 dbSNP
rs879651012 553 dbSNP
rs1260504453 558 dbSNP
rs754666420 561 dbSNP
rs1207351505 581 dbSNP
rs575598848 582 dbSNP
rs62235876 589 dbSNP
rs1484877285 591 dbSNP
rs1025374090 594 dbSNP
rs1216618584 600 dbSNP
rs1425178437 601 dbSNP
rs908898058 601 dbSNP
rs941580231 601 dbSNP
rs1331419261 603 dbSNP
rs9606762 606 dbSNP
rs895041220 622 dbSNP
rs1454141142 625 dbSNP
rs923051047 631 dbSNP
rs368654453 632 dbSNP
rs1303911074 633 dbSNP
rs931129102 645 dbSNP
rs1313547421 648 dbSNP
rs1361893210 664 dbSNP
rs1287720072 677 dbSNP
rs896949101 678 dbSNP
rs1389824069 681 dbSNP
rs575063869 683 dbSNP
rs1317851345 684 dbSNP
rs150577166 684 dbSNP
rs373265082 684 dbSNP
rs1242812508 685 dbSNP
rs1278692526 688 dbSNP
rs1347766503 694 dbSNP
rs990094155 700 dbSNP
rs1173795931 713 dbSNP
rs41282549 717 dbSNP
rs1031672998 718 dbSNP
rs912247586 736 dbSNP
rs535220293 738 dbSNP
rs985510698 751 dbSNP
rs932286191 752 dbSNP
rs1024383729 763 dbSNP
rs1434023926 765 dbSNP
rs1187117052 766 dbSNP
rs1360908525 766 dbSNP
rs1466309433 774 dbSNP
rs922177113 779 dbSNP
rs1012936241 782 dbSNP
rs1374294299 784 dbSNP
rs1449345120 787 dbSNP
rs566183604 789 dbSNP
rs188894312 791 dbSNP
rs1370718106 797 dbSNP
rs559056017 798 dbSNP
rs1005805888 801 dbSNP
rs1313399124 806 dbSNP
rs1225711664 816 dbSNP
rs376083231 816 dbSNP
rs958208800 819 dbSNP
rs539054014 825 dbSNP
rs868780895 832 dbSNP
rs1047303839 836 dbSNP
rs929005618 838 dbSNP
rs755332513 839 dbSNP
rs978168487 840 dbSNP
rs971203255 846 dbSNP
rs1194130341 847 dbSNP
rs570092289 852 dbSNP
rs368028374 853 dbSNP
rs1427225861 857 dbSNP
rs901492279 861 dbSNP
rs553355078 863 dbSNP
rs1040174478 875 dbSNP
rs184032553 878 dbSNP
rs1012652190 879 dbSNP
rs1324147808 884 dbSNP
rs910403543 885 dbSNP
rs895101162 896 dbSNP
rs550131747 900 dbSNP
rs139004951 901 dbSNP
rs1360463988 908 dbSNP
rs1294226315 909 dbSNP
rs566901409 909 dbSNP
rs1304315222 911 dbSNP
rs1460284113 915 dbSNP
rs1220030167 918 dbSNP
rs1372358170 920 dbSNP
rs567546900 926 dbSNP
rs1171048645 931 dbSNP
rs547276503 941 dbSNP
rs1451311206 955 dbSNP
rs1467835709 959 dbSNP
rs1221996404 961 dbSNP
rs897003052 963 dbSNP
rs527443314 964 dbSNP
rs1484847201 965 dbSNP
rs1185861342 968 dbSNP
rs1420238670 977 dbSNP
rs1383413762 983 dbSNP
rs190940171 985 dbSNP
rs977363174 987 dbSNP
rs1417378806 988 dbSNP
rs370995187 1002 dbSNP
rs890856423 1004 dbSNP
rs1049445520 1009 dbSNP
rs1194361497 1013 dbSNP
rs1480503289 1016 dbSNP
rs932311832 1018 dbSNP
rs1325925779 1019 dbSNP
rs1252306149 1021 dbSNP
rs9609038 1030 dbSNP
rs1357968227 1035 dbSNP
rs1340545637 1040 dbSNP
rs531285897 1041 dbSNP
rs991551600 1042 dbSNP
rs185920559 1048 dbSNP
rs1228593204 1057 dbSNP
rs924136861 1073 dbSNP
rs1291758241 1075 dbSNP
rs978219288 1081 dbSNP
rs1214921866 1083 dbSNP
rs1263850240 1085 dbSNP
rs970869375 1087 dbSNP
rs1185871903 1092 dbSNP
rs1314428676 1095 dbSNP
rs1165224634 1099 dbSNP
rs542599421 1106 dbSNP
rs917990971 1118 dbSNP
rs990877892 1120 dbSNP
rs1160418578 1121 dbSNP
rs1400515962 1121 dbSNP
rs959642714 1123 dbSNP
rs1413531514 1124 dbSNP
rs1310532335 1129 dbSNP
rs114734655 1134 dbSNP
rs1308439390 1138 dbSNP
rs145135259 1142 dbSNP
rs1363650503 1151 dbSNP
rs1285614918 1157 dbSNP
rs998436645 1161 dbSNP
rs961265076 1163 dbSNP
rs1162933267 1164 dbSNP
rs58640678 1171 dbSNP
rs1445310067 1173 dbSNP
rs775755888 1175 dbSNP
rs541276943 1178 dbSNP
rs1208722136 1180 dbSNP
rs901519950 1182 dbSNP
rs374825925 1193 dbSNP
rs1008476578 1199 dbSNP
rs1189822324 1204 dbSNP
rs1231426025 1206 dbSNP
rs1469854160 1207 dbSNP
rs370605383 1208 dbSNP
rs888832950 1216 dbSNP
rs1054203156 1218 dbSNP
rs1049951541 1222 dbSNP
rs996581534 1225 dbSNP
rs1251640157 1226 dbSNP
rs924450216 1228 dbSNP
rs9606761 1231 dbSNP
rs1352374909 1232 dbSNP
rs1054033668 1233 dbSNP
rs373828068 1238 dbSNP
rs936955524 1239 dbSNP
rs1489986972 1255 dbSNP
rs1231917252 1261 dbSNP
rs1302612411 1268 dbSNP
rs1291698148 1270 dbSNP
rs1202217104 1274 dbSNP
rs949948572 1275 dbSNP
rs1437452493 1280 dbSNP
rs924189206 1288 dbSNP
rs1240344047 1293 dbSNP
rs1193513400 1295 dbSNP
rs1356424414 1296 dbSNP
rs1479316567 1298 dbSNP
rs917251872 1304 dbSNP
rs181287363 1305 dbSNP
rs8630 1309 dbSNP
rs958691621 1329 dbSNP
rs1334822615 1332 dbSNP
rs1402141511 1335 dbSNP
rs1438483200 1336 dbSNP
rs556329536 1338 dbSNP
rs536602349 1347 dbSNP
rs984205770 1349 dbSNP
rs1411432989 1352 dbSNP
rs1268492454 1353 dbSNP
rs1343478966 1363 dbSNP
rs752605804 1375 dbSNP
rs1302456105 1379 dbSNP
rs1376644295 1384 dbSNP
rs1304393986 1385 dbSNP
rs3067260 1386 dbSNP
rs1156930178 1395 dbSNP
rs549480509 1398 dbSNP
rs868714994 1401 dbSNP
rs1412994071 1402 dbSNP
rs1184705247 1404 dbSNP
rs386395203 1406 dbSNP
rs918056035 1406 dbSNP
rs1391273646 1407 dbSNP
rs1425291282 1407 dbSNP
rs1459591452 1407 dbSNP
rs1491130046 1407 dbSNP
rs33914926 1407 dbSNP
rs77182933 1407 dbSNP
rs1387905236 1408 dbSNP
rs1488927444 1409 dbSNP
rs1025780866 1410 dbSNP
rs1193729059 1411 dbSNP
rs1264778655 1413 dbSNP
rs1474021177 1422 dbSNP
rs1163646136 1432 dbSNP
rs190122162 1436 dbSNP
rs540145024 1437 dbSNP
rs965578654 1438 dbSNP
rs1420288901 1444 dbSNP
rs955979854 1447 dbSNP
rs1263855606 1466 dbSNP
rs1353649002 1470 dbSNP
rs919948525 1471 dbSNP
rs113483027 1472 dbSNP
rs1054636528 1473 dbSNP
rs1237296594 1473 dbSNP
rs1260556649 1487 dbSNP
rs999935336 1493 dbSNP
rs1453880231 1496 dbSNP
rs1219521451 1497 dbSNP
rs144406312 1502 dbSNP
rs1041512921 1506 dbSNP
rs1180876246 1510 dbSNP
rs1256464040 1511 dbSNP
rs1202864452 1532 dbSNP
rs771497337 1533 dbSNP
rs961318449 1537 dbSNP
rs917199305 1541 dbSNP
rs1440163644 1542 dbSNP
rs747410659 1550 dbSNP
rs1160397904 1553 dbSNP
rs773642436 1554 dbSNP
rs1055637636 1557 dbSNP
rs937367910 1561 dbSNP
rs1008111179 1570 dbSNP
rs955398354 1573 dbSNP
rs1308987156 1576 dbSNP
rs1229909934 1584 dbSNP
rs1028135735 1588 dbSNP
rs1282441930 1589 dbSNP
rs116386177 1594 dbSNP
rs892876631 1595 dbSNP
rs1208783904 1597 dbSNP
rs1332784100 1603 dbSNP
rs1054085204 1621 dbSNP
rs186145267 1623 dbSNP
rs1237277725 1624 dbSNP
rs1440101033 1627 dbSNP
rs533761206 1640 dbSNP
rs1393158873 1642 dbSNP
rs1432572629 1652 dbSNP
rs376458022 1654 dbSNP
rs951470764 1658 dbSNP
rs918750444 1672 dbSNP
rs976883011 1677 dbSNP
rs141040023 1683 dbSNP
rs1468483021 1697 dbSNP
rs902814928 1700 dbSNP
rs1367496234 1705 dbSNP
rs1043038581 1708 dbSNP
rs1007129323 1714 dbSNP
rs1301272979 1722 dbSNP
rs181701741 1727 dbSNP
rs76352804 1729 dbSNP
rs1479255068 1733 dbSNP
rs1257066179 1741 dbSNP
rs1000356204 1743 dbSNP
rs1240866344 1747 dbSNP
rs1055280041 1748 dbSNP
rs938122936 1759 dbSNP
rs562602773 1765 dbSNP
rs548706853 1766 dbSNP
rs1488115774 1769 dbSNP
rs920000791 1778 dbSNP
rs1193175592 1780 dbSNP
rs1269484231 1783 dbSNP
rs1426840322 1788 dbSNP
rs1464036508 1795 dbSNP
rs1424571727 1798 dbSNP
rs974114686 1805 dbSNP
rs1248157578 1818 dbSNP
rs1349666584 1819 dbSNP
rs1014082792 1828 dbSNP
rs202024432 1829 dbSNP
rs200849606 1833 dbSNP
rs199884774 1834 dbSNP
rs895636760 1834 dbSNP
rs11325761 1835 dbSNP
rs398101724 1835 dbSNP
rs9609037 1840 dbSNP
rs1220160601 1841 dbSNP
rs1346956994 1843 dbSNP
rs908515442 1848 dbSNP
rs1320906141 1856 dbSNP
rs1222157812 1863 dbSNP
rs1268343135 1867 dbSNP
rs1487293687 1870 dbSNP
rs937233624 1881 dbSNP
rs987141936 1884 dbSNP
rs1478884832 1885 dbSNP
rs1365997614 1886 dbSNP
rs955301597 1890 dbSNP
rs1406348410 1894 dbSNP
rs1048349534 1898 dbSNP
rs1028605503 1899 dbSNP
rs930057822 1900 dbSNP
rs1419685236 1903 dbSNP
rs975267632 1904 dbSNP
rs1322696353 1911 dbSNP
rs918712548 1915 dbSNP
rs190148042 1919 dbSNP
rs1405635289 1920 dbSNP
rs1282094478 1921 dbSNP
rs1378124729 1922 dbSNP
rs1335190855 1925 dbSNP
rs1291826152 1927 dbSNP
rs1416512339 1928 dbSNP
rs1417883519 1930 dbSNP
rs1351410116 1931 dbSNP
rs1032723119 1932 dbSNP
rs1215809505 1933 dbSNP
rs766654414 1935 dbSNP
rs965559343 1936 dbSNP
rs998524480 1937 dbSNP
rs1167818975 1939 dbSNP
rs1450679780 1940 dbSNP
rs148129737 1943 dbSNP
rs985722490 1948 dbSNP
rs187497355 1951 dbSNP
rs1459656233 1952 dbSNP
rs1236539865 1955 dbSNP
rs1439551240 1955 dbSNP
rs1159801148 1958 dbSNP
rs1360553433 1959 dbSNP
rs958275306 1962 dbSNP
rs1331679177 1963 dbSNP
rs1358198822 1967 dbSNP
rs1448381764 1967 dbSNP
rs1210471553 1971 dbSNP
rs1374398120 1972 dbSNP
rs1443918642 1975 dbSNP
rs146820373 1977 dbSNP
rs1195127809 1978 dbSNP
rs1342826777 1981 dbSNP
rs1299860426 1982 dbSNP
rs1278077720 1983 dbSNP
rs1443210536 1985 dbSNP
rs572758556 1987 dbSNP
rs878868331 1987 dbSNP
rs978485848 1988 dbSNP
rs1243872942 1989 dbSNP
rs1382208654 1990 dbSNP
rs967446995 1992 dbSNP
rs1020017031 1993 dbSNP
rs1403799881 1993 dbSNP
rs1414622432 1993 dbSNP
rs1491057586 1993 dbSNP
rs375019336 1993 dbSNP
rs397723342 1993 dbSNP
rs555969142 1993 dbSNP
rs56242112 1993 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugguuuccGUCGGGACCGUuga 5'
                  |||||: ||||   
Target 5' uugcacucCAGCCUGGGCA--- 3'
4 - 22
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000403268.1 | 3UTR | AGGACAUUGCACUCCAGCCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000403268.1 | 3UTR | ACAUUGCACUCCAGCCUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
167 hsa-miR-6501-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT156859 FAM126B family with sequence similarity 126 member B 2 2
MIRT173355 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT369102 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT442037 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT442829 AZIN1 antizyme inhibitor 1 2 2
MIRT443729 CCND2 cyclin D2 2 2
MIRT453771 NUCB1 nucleobindin 1 2 10
MIRT453875 IFRD1 interferon related developmental regulator 1 2 12
MIRT454229 OSBPL10 oxysterol binding protein like 10 2 11
MIRT458829 RPUSD2 RNA pseudouridylate synthase domain containing 2 2 2
MIRT459898 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 10
MIRT464162 VMP1 vacuole membrane protein 1 2 15
MIRT495411 SMAD2 SMAD family member 2 2 2
MIRT496906 TRIM56 tripartite motif containing 56 2 2
MIRT498653 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 6
MIRT498706 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT499308 ZNF485 zinc finger protein 485 2 6
MIRT499707 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 10
MIRT499755 CIRH1A UTP4, small subunit processome component 2 6
MIRT499827 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT503691 MAVS mitochondrial antiviral signaling protein 2 2
MIRT512418 LAYN layilin 2 4
MIRT516232 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT522554 MCAM melanoma cell adhesion molecule 2 4
MIRT523760 FBXO27 F-box protein 27 2 4
MIRT525107 PRKD2 protein kinase D2 2 2
MIRT525919 KIAA0391 KIAA0391 2 2
MIRT527246 COMMD6 COMM domain containing 6 2 2
MIRT527564 ADCY7 adenylate cyclase 7 2 2
MIRT528764 CD1D CD1d molecule 2 2
MIRT529362 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT529464 ZNF546 zinc finger protein 546 2 2
MIRT530676 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531635 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531909 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532172 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534234 SLC25A16 solute carrier family 25 member 16 2 4
MIRT534561 RRAGD Ras related GTP binding D 2 2
MIRT534971 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536738 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT538544 CELF1 CUGBP Elav-like family member 1 2 2
MIRT540462 ZNF71 zinc finger protein 71 2 2
MIRT540554 PPIC peptidylprolyl isomerase C 2 2
MIRT543593 KIAA1549 KIAA1549 2 2
MIRT543963 RNF20 ring finger protein 20 2 2
MIRT544047 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT544670 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT550665 TRAF1 TNF receptor associated factor 1 2 2
MIRT558540 CSNK1G3 casein kinase 1 gamma 3 2 4
MIRT574917 Vmp1 vacuole membrane protein 1 2 9
MIRT575298 Osbpl10 oxysterol binding protein-like 10 2 7
MIRT607960 SNX22 sorting nexin 22 2 2
MIRT610649 TIPRL TOR signaling pathway regulator 2 8
MIRT615899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT617438 CCS copper chaperone for superoxide dismutase 2 2
MIRT617510 C5orf45 MRN complex interacting protein 2 2
MIRT617548 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT620565 WBSCR27 methyltransferase like 27 2 2
MIRT623166 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624161 DGKE diacylglycerol kinase epsilon 2 2
MIRT626090 MKLN1 muskelin 1 2 2
MIRT627010 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627073 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627136 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627340 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627436 TAS2R5 taste 2 receptor member 5 2 2
MIRT628273 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629091 F2RL1 F2R like trypsin receptor 1 2 4
MIRT629282 UNC13A unc-13 homolog A 2 2
MIRT630122 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630247 SMTNL2 smoothelin like 2 2 2
MIRT631260 CENPM centromere protein M 2 2
MIRT631336 CD300E CD300e molecule 2 2
MIRT631399 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632593 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632991 DUSP18 dual specificity phosphatase 18 2 2
MIRT633079 CXorf21 chromosome X open reading frame 21 2 2
MIRT634223 TMEM132B transmembrane protein 132B 2 2
MIRT635046 MYH11 myosin heavy chain 11 2 2
MIRT636444 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636649 CDK4 cyclin dependent kinase 4 2 2
MIRT637129 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637282 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637527 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637783 OLA1 Obg like ATPase 1 2 2
MIRT637920 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638238 SLC1A5 solute carrier family 1 member 5 2 2
MIRT638444 PLXDC2 plexin domain containing 2 2 2
MIRT639765 GPR45 G protein-coupled receptor 45 2 2
MIRT640437 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT643006 ZNF829 zinc finger protein 829 2 2
MIRT644233 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644661 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644957 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT645086 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645256 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT645861 GBP6 guanylate binding protein family member 6 2 2
MIRT645987 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646502 FAM217B family with sequence similarity 217 member B 2 2
MIRT646811 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT647706 NFX1 nuclear transcription factor, X-box binding 1 2 2
MIRT649657 TEP1 telomerase associated protein 1 2 2
MIRT650550 YIPF4 Yip1 domain family member 4 2 2
MIRT650785 GSR glutathione-disulfide reductase 2 2
MIRT651461 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652098 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT654117 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT658901 DPY19L4 dpy-19 like 4 2 2
MIRT659370 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT662537 MTAP methylthioadenosine phosphorylase 2 2
MIRT662617 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT663491 IYD iodotyrosine deiodinase 2 2
MIRT663899 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT664552 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT664582 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664953 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT665193 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665446 WDR17 WD repeat domain 17 2 2
MIRT665894 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT666480 SBNO1 strawberry notch homolog 1 2 2
MIRT666514 RNF170 ring finger protein 170 2 2
MIRT666692 RBM23 RNA binding motif protein 23 2 2
MIRT666791 PSMD1 proteasome 26S subunit, non-ATPase 1 2 2
MIRT667453 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT667553 LRAT lecithin retinol acyltransferase 2 4
MIRT667744 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668080 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668114 GK5 glycerol kinase 5 (putative) 2 2
MIRT668501 ESYT2 extended synaptotagmin 2 2 2
MIRT668942 CNKSR3 CNKSR family member 3 2 2
MIRT670408 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671134 CD226 CD226 molecule 2 2
MIRT671919 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672287 GP2 glycoprotein 2 2 2
MIRT672427 POLR2D RNA polymerase II subunit D 2 2
MIRT672762 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672923 LRRC2 leucine rich repeat containing 2 2 2
MIRT673150 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673309 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT673560 PLA2G16 phospholipase A2 group XVI 2 2
MIRT673895 DCTN6 dynactin subunit 6 2 2
MIRT674513 PRR23A proline rich 23A 2 2
MIRT674614 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT674747 SLC16A1 solute carrier family 16 member 1 2 2
MIRT675693 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT675890 SNAP29 synaptosome associated protein 29 2 2
MIRT685271 KIAA1143 KIAA1143 2 2
MIRT686057 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT693886 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT695594 TMEM199 transmembrane protein 199 2 2
MIRT696592 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT698041 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT699907 RUNDC1 RUN domain containing 1 2 2
MIRT706608 CYB5B cytochrome b5 type B 2 2
MIRT706628 PNPT1 polyribonucleotide nucleotidyltransferase 1 2 2
MIRT706640 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT706676 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706723 RFK riboflavin kinase 2 2
MIRT706857 MAFF MAF bZIP transcription factor F 2 2
MIRT706891 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706958 FANCC Fanconi anemia complementation group C 2 2
MIRT706976 XPO5 exportin 5 2 2
MIRT707010 RRP36 ribosomal RNA processing 36 2 2
MIRT707028 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707068 MED29 mediator complex subunit 29 2 2
MIRT713253 ZFP30 ZFP30 zinc finger protein 2 2
MIRT719130 NR2F6 nuclear receptor subfamily 2 group F member 6 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6501-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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