pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF576   
Synonyms -
Description zinc finger protein 576
Transcript NM_001145347   
Other Transcripts NM_024327   
Expression
Putative miRNA Targets on ZNF576
3'UTR of ZNF576
(miRNA target sites are highlighted)
>ZNF576|NM_001145347|3'UTR
   1 GTGCAGCTTAAGCCTCTCCACGGTGACGGGTGGCTCTGTGGCTGGTAGGACTCACCCATGATATGGGGTGCAGGAACTCT
  81 GGGGGCCCTGAAGGATTTGCTTCCCTCCCCTGGGAAGGCAGAGGGCTCTTAATAAAGAGGACCCAGAAGATTCTTATTTA
 161 GAGCTTCAGTCTTTGGAGCACACAGGGCCTTCGTGAGACAGTGAAATCAGATAATAATGAGATCTTTTGTTAAAAAAAAA
 241 AAATGGGAAGGGAGTGCGGGAGAGAAATGGTTTGTGTCTCCCTTATTCCCAGTTAAATACCTAGCTGCAGATTGTGCCAT
 321 CACCCTTCATTCTTCCCAGATGGATGCCATGGGCTATGGGAGCAAATTGCCCTGGACCTTTGCCTGAATGGGGGCAGGAA
 401 AGGTGAGGTGTTGCTGGCCTGTAATGCCACCAGGTGAGTTCCAGATGTGGAGCAACTTGGGCTTTTGGGGATGGGGCAGC
 481 AAAGTTGGGAGCTGGACCCCAATTGAGTGGGGGTAGCAATTGGAGTCCTTGTGTCTCTTTTCCACCCCCTGCCATCCTCA
 561 CTTAGAGGGGCCATGGCACTAGATGGCACTAGTCCCCCGATAATTTATGTCTCGTTGAAATAATTTTGTATATCATTCTA
 641 GTCCTGAAATATTTTTTTCATATGTGTAGGTGAAATGGTATGAATAAGCTAACAGGAATAGTATCTAAAAACAGAAAACA
 721 TCCATATTAAAATGTCTAAACAGGGAGCTCTGGCTTTTGAGTGGGAATTTCCAGAGAACATAAGGGTGTGGGCAGGTGGG
 801 GGAACTCAGGCCAGAGTTGGCCTCGCTTTGTGGGGAAACTGGTTTGGAATCAAACAGAGATACCTTCTGTTTCGGGTTTT
 881 ATTTGGCCAACACTGGGAGATTTCCCATTAAGATCCTATTTTCAGCTCTCTTGAAAGGCCCAACCTAGGCTGACATTGTC
 961 AGCAGGGGCAGGACAGAAGTTACAACAGGCTGGAGGGAGCAGTGGGTGTCACCCTCAACTGGAGATGAGTCCCACCAGGC
1041 CAGTTTTACCCCCTTAGTTACCTGCCCTGCACCTGCAGACAATGGTCGATGCCTTGCATATAATACTTATAGACTCTGTT
1121 TATGTTGAGGGATGTTTTTAAAGCCCACAGGTGAGGTGGATGTGGTAGACTGATCAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucUCCGUCCAAGG-----ACCUAGUa 5'
            |||:: |||||     |||| || 
Target 5' ccAGGTGAGTTCCAGATGTGGAGCAa 3'
430 - 455 131.00 -14.50
2
miRNA  3' ucuccGUCCAAGGACC-UAGUa 5'
               | ||||  ||| |||| 
Target 5' ggaaaCTGGTT--TGGAATCAa 3'
834 - 853 120.00 -9.10
3
miRNA  3' ucuccGUCCAAGGACCUAGUa 5'
               || || ::|||| || 
Target 5' agcttCA-GTCTTTGGAGCAc 3'
162 - 181 119.00 -9.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30539984 7 COSMIC
COSN30521288 23 COSMIC
COSN30542190 31 COSMIC
COSN20093610 48 COSMIC
COSN30498769 51 COSMIC
COSN30541734 91 COSMIC
COSN9850789 130 COSMIC
COSN27244191 146 COSMIC
COSN28882357 184 COSMIC
COSN32096094 196 COSMIC
COSN20115838 244 COSMIC
COSN20093611 431 COSMIC
COSN1216255 927 COSMIC
COSN22280336 1529 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs202092766 5 dbSNP
rs755278793 7 dbSNP
rs999704858 10 dbSNP
rs1395703533 14 dbSNP
rs1476442575 15 dbSNP
rs959142426 17 dbSNP
rs1292770391 18 dbSNP
rs779866461 20 dbSNP
rs200110905 22 dbSNP
rs756617351 23 dbSNP
rs201933599 28 dbSNP
rs749276993 29 dbSNP
rs757440896 30 dbSNP
rs779206057 31 dbSNP
rs746099708 38 dbSNP
rs768555611 42 dbSNP
rs1022298874 46 dbSNP
rs1049955824 47 dbSNP
rs369132386 48 dbSNP
rs1198341964 51 dbSNP
rs755611477 54 dbSNP
rs960384739 65 dbSNP
rs1434983479 68 dbSNP
rs977383565 72 dbSNP
rs1236410810 75 dbSNP
rs1166102836 83 dbSNP
rs1278761774 85 dbSNP
rs1442607968 86 dbSNP
rs1395627682 89 dbSNP
rs1023418899 90 dbSNP
rs924653279 91 dbSNP
rs1410354656 94 dbSNP
rs965413268 100 dbSNP
rs556695729 108 dbSNP
rs1404013176 123 dbSNP
rs1437143574 138 dbSNP
rs1406366740 147 dbSNP
rs112732012 167 dbSNP
rs749102131 170 dbSNP
rs1234940756 176 dbSNP
rs932495507 180 dbSNP
rs940629722 183 dbSNP
rs1257616160 193 dbSNP
rs1048267766 194 dbSNP
rs909797315 195 dbSNP
rs975971174 200 dbSNP
rs923172088 204 dbSNP
rs1224537341 206 dbSNP
rs1268951991 211 dbSNP
rs1339253704 212 dbSNP
rs1215634174 213 dbSNP
rs1277271476 214 dbSNP
rs1282211833 222 dbSNP
rs1413175930 223 dbSNP
rs939960404 225 dbSNP
rs1343478379 230 dbSNP
rs1416657523 230 dbSNP
rs112881374 232 dbSNP
rs58114847 232 dbSNP
rs796438870 232 dbSNP
rs1049757528 233 dbSNP
rs59397990 245 dbSNP
rs1036682406 246 dbSNP
rs1484633521 253 dbSNP
rs1269803624 255 dbSNP
rs73556563 258 dbSNP
rs528279529 259 dbSNP
rs1055303664 260 dbSNP
rs894605465 261 dbSNP
rs1271055505 262 dbSNP
rs1013511200 265 dbSNP
rs1475729631 267 dbSNP
rs1170398248 277 dbSNP
rs774284230 279 dbSNP
rs1383221800 282 dbSNP
rs1334486153 283 dbSNP
rs1294179658 286 dbSNP
rs999631189 289 dbSNP
rs1035262987 293 dbSNP
rs896733107 304 dbSNP
rs1392366073 311 dbSNP
rs1432125041 319 dbSNP
rs1347412090 323 dbSNP
rs1011907320 335 dbSNP
rs1380055785 337 dbSNP
rs1021826182 338 dbSNP
rs761273174 342 dbSNP
rs1461282186 351 dbSNP
rs1317066698 352 dbSNP
rs374514333 353 dbSNP
rs1166713259 354 dbSNP
rs1426361267 356 dbSNP
rs771592362 362 dbSNP
rs1186537755 367 dbSNP
rs1476366486 374 dbSNP
rs2240933 375 dbSNP
rs1300365279 380 dbSNP
rs1468788462 383 dbSNP
rs1014776222 384 dbSNP
rs1224145454 387 dbSNP
rs961902375 389 dbSNP
rs1294968676 393 dbSNP
rs1357763249 395 dbSNP
rs975907199 422 dbSNP
rs562231200 431 dbSNP
rs1372263675 436 dbSNP
rs1292820096 439 dbSNP
rs1358789513 447 dbSNP
rs1460164931 453 dbSNP
rs1203594052 454 dbSNP
rs530886347 457 dbSNP
rs1447649474 469 dbSNP
rs965362990 483 dbSNP
rs1190436631 485 dbSNP
rs550995454 488 dbSNP
rs931849931 493 dbSNP
rs1028828337 499 dbSNP
rs1192999113 503 dbSNP
rs985487004 504 dbSNP
rs1443801791 510 dbSNP
rs953868371 511 dbSNP
rs946840850 512 dbSNP
rs984359251 514 dbSNP
rs1205459546 516 dbSNP
rs1344480938 521 dbSNP
rs1451235666 522 dbSNP
rs1044223275 525 dbSNP
rs1157616619 526 dbSNP
rs1303893339 528 dbSNP
rs1389992328 529 dbSNP
rs924036064 544 dbSNP
rs1298444901 546 dbSNP
rs1385061414 547 dbSNP
rs909742286 548 dbSNP
rs1436577837 550 dbSNP
rs1172403828 552 dbSNP
rs1435285897 561 dbSNP
rs939905771 566 dbSNP
rs1156795588 569 dbSNP
rs768623662 573 dbSNP
rs1418330574 575 dbSNP
rs563291522 577 dbSNP
rs772760236 580 dbSNP
rs1178062256 590 dbSNP
rs972658582 599 dbSNP
rs570756451 600 dbSNP
rs1313949072 609 dbSNP
rs191807924 610 dbSNP
rs1054850979 611 dbSNP
rs1237237202 614 dbSNP
rs894881171 615 dbSNP
rs1316760387 616 dbSNP
rs1044746767 620 dbSNP
rs946524700 621 dbSNP
rs547329550 625 dbSNP
rs1210615110 629 dbSNP
rs904726794 630 dbSNP
rs79719618 631 dbSNP
rs1031902445 634 dbSNP
rs1414907110 652 dbSNP
rs1460843869 654 dbSNP
rs536078374 656 dbSNP
rs1287102849 661 dbSNP
rs901141751 664 dbSNP
rs1015123052 671 dbSNP
rs143289457 678 dbSNP
rs1473709550 685 dbSNP
rs997356225 686 dbSNP
rs775911890 690 dbSNP
rs763244485 694 dbSNP
rs764632403 702 dbSNP
rs954252432 708 dbSNP
rs200242113 713 dbSNP
rs1486067744 722 dbSNP
rs1417018293 725 dbSNP
rs535941540 731 dbSNP
rs1203964360 739 dbSNP
rs1017150505 741 dbSNP
rs536736594 743 dbSNP
rs961220415 746 dbSNP
rs1363972532 748 dbSNP
rs953289358 769 dbSNP
rs1261693475 781 dbSNP
rs1210925081 787 dbSNP
rs374448203 798 dbSNP
rs1173684880 799 dbSNP
rs1233504656 800 dbSNP
rs927875769 801 dbSNP
rs1404694044 802 dbSNP
rs371323354 805 dbSNP
rs757359228 818 dbSNP
rs1303931251 825 dbSNP
rs986429608 826 dbSNP
rs990888252 858 dbSNP
rs1459716850 861 dbSNP
rs1393431752 862 dbSNP
rs916271523 862 dbSNP
rs867416543 875 dbSNP
rs1370279407 883 dbSNP
rs979448018 895 dbSNP
rs1428467697 901 dbSNP
rs1263092040 907 dbSNP
rs767680826 908 dbSNP
rs151285356 914 dbSNP
rs904675646 928 dbSNP
rs73556565 931 dbSNP
rs1230425107 940 dbSNP
rs1053265014 945 dbSNP
rs1357953197 952 dbSNP
rs901424613 954 dbSNP
rs545353260 966 dbSNP
rs1050179670 967 dbSNP
rs1045749893 969 dbSNP
rs888029428 970 dbSNP
rs116230528 972 dbSNP
rs1479550689 980 dbSNP
rs756353141 1001 dbSNP
rs1326263176 1004 dbSNP
rs1406189758 1006 dbSNP
rs1035991829 1007 dbSNP
rs377487192 1009 dbSNP
rs897588994 1014 dbSNP
rs1473397612 1034 dbSNP
rs1196823678 1040 dbSNP
rs1453045548 1041 dbSNP
rs572771126 1053 dbSNP
rs1428073590 1054 dbSNP
rs1194601366 1056 dbSNP
rs1453002920 1059 dbSNP
rs532284521 1062 dbSNP
rs1248030667 1079 dbSNP
rs1017035048 1090 dbSNP
rs961168806 1099 dbSNP
rs953216821 1101 dbSNP
rs888586077 1102 dbSNP
rs140538463 1111 dbSNP
rs1232000697 1113 dbSNP
rs1361355557 1117 dbSNP
rs1460815992 1119 dbSNP
rs1438303822 1126 dbSNP
rs117820749 1134 dbSNP
rs968661571 1139 dbSNP
rs960593316 1163 dbSNP
rs111291192 1165 dbSNP
rs1411968762 1180 dbSNP
rs1433424398 1183 dbSNP
rs916201074 1184 dbSNP
rs1173641324 1190 dbSNP
rs1344984763 1194 dbSNP
rs967755858 1200 dbSNP
rs1231518573 1201 dbSNP
rs979551824 1203 dbSNP
rs1483142951 1204 dbSNP
rs564566520 1216 dbSNP
rs540542746 1228 dbSNP
rs1253367588 1232 dbSNP
rs1208041841 1255 dbSNP
rs1219839949 1273 dbSNP
rs956798916 1276 dbSNP
rs1281011077 1279 dbSNP
rs1220858347 1284 dbSNP
rs1348356318 1290 dbSNP
rs1278665079 1303 dbSNP
rs923701065 1311 dbSNP
rs917980202 1312 dbSNP
rs1413055041 1322 dbSNP
rs935115522 1331 dbSNP
rs1275162106 1332 dbSNP
rs1416651787 1334 dbSNP
rs1053213164 1342 dbSNP
rs1483912217 1348 dbSNP
rs749053127 1359 dbSNP
rs1472729383 1362 dbSNP
rs922803097 1365 dbSNP
rs934209623 1366 dbSNP
rs1474626010 1381 dbSNP
rs754799684 1382 dbSNP
rs1267660080 1383 dbSNP
rs1212151298 1388 dbSNP
rs980962099 1391 dbSNP
rs145816734 1397 dbSNP
rs889747054 1399 dbSNP
rs1330910217 1404 dbSNP
rs941642072 1419 dbSNP
rs1427306795 1435 dbSNP
rs546989041 1440 dbSNP
rs1354975324 1441 dbSNP
rs778773403 1444 dbSNP
rs1170339469 1446 dbSNP
rs1391236186 1451 dbSNP
rs748058009 1458 dbSNP
rs10410931 1459 dbSNP
rs370505508 1463 dbSNP
rs1161930227 1467 dbSNP
rs1034835882 1477 dbSNP
rs1318112187 1479 dbSNP
rs772778051 1485 dbSNP
rs1391267451 1493 dbSNP
rs746562121 1495 dbSNP
rs546014023 1497 dbSNP
rs1474635633 1498 dbSNP
rs1023554708 1502 dbSNP
rs932954898 1504 dbSNP
rs1413899919 1507 dbSNP
rs1183048085 1513 dbSNP
rs968083318 1516 dbSNP
rs888862374 1524 dbSNP
rs1007843469 1525 dbSNP
rs1466134640 1546 dbSNP
rs979112868 1547 dbSNP
rs1295418022 1552 dbSNP
rs1359940321 1553 dbSNP
rs1381645295 1560 dbSNP
rs1298166228 1564 dbSNP
rs1212061885 1569 dbSNP
rs549595368 1569 dbSNP
rs1021418291 1573 dbSNP
rs1290712476 1576 dbSNP
rs542223662 1581 dbSNP
rs776155645 1584 dbSNP
rs1344055547 1585 dbSNP
rs904445896 1586 dbSNP
rs1243432298 1587 dbSNP
rs1367796698 1588 dbSNP
rs1436455719 1588 dbSNP
rs956444737 1588 dbSNP
rs975817868 1589 dbSNP
rs1030977208 1590 dbSNP
rs771719939 1593 dbSNP
rs1166430280 1599 dbSNP
rs1407760009 1601 dbSNP
rs1418151174 1608 dbSNP
rs1321986890 1617 dbSNP
rs1223283416 1622 dbSNP
rs569347743 1624 dbSNP
rs922750779 1625 dbSNP
rs763333040 1627 dbSNP
rs1239919150 1629 dbSNP
rs1485255961 1631 dbSNP
rs1188489606 1635 dbSNP
rs538388807 1641 dbSNP
rs911471751 1643 dbSNP
rs556788353 1644 dbSNP
rs981357249 1668 dbSNP
rs1038363395 1672 dbSNP
rs1224025765 1673 dbSNP
rs1305902279 1681 dbSNP
rs897187217 1683 dbSNP
rs1229801927 1689 dbSNP
rs185284306 1690 dbSNP
rs371374838 1699 dbSNP
rs933008704 1700 dbSNP
rs1439566899 1701 dbSNP
rs1453078282 1712 dbSNP
rs1353419750 1715 dbSNP
rs539064824 1718 dbSNP
rs1393153376 1723 dbSNP
rs1431577322 1723 dbSNP
rs1172904766 1725 dbSNP
rs1433611717 1729 dbSNP
rs896267293 1730 dbSNP
rs1426997115 1731 dbSNP
rs762376213 1733 dbSNP
rs1367216562 1742 dbSNP
rs552527836 1753 dbSNP
rs1205905681 1758 dbSNP
rs1484058628 1770 dbSNP
rs1278872060 1771 dbSNP
rs113604124 1774 dbSNP
rs1313222010 1777 dbSNP
rs143066548 1780 dbSNP
rs1043295179 1782 dbSNP
rs1349444177 1788 dbSNP
rs1229742164 1789 dbSNP
rs1000761553 1793 dbSNP
rs1030595865 1796 dbSNP
rs1373076943 1798 dbSNP
rs956392385 1799 dbSNP
rs998625805 1800 dbSNP
rs1315825381 1804 dbSNP
rs1156605017 1811 dbSNP
rs1417588028 1813 dbSNP
rs1411555736 1814 dbSNP
rs975765803 1819 dbSNP
rs1030089996 1825 dbSNP
rs55915894 1829 dbSNP
rs985646005 1842 dbSNP
rs1255485140 1844 dbSNP
rs895727752 1861 dbSNP
rs555591443 1862 dbSNP
rs1258160741 1865 dbSNP
rs1214042523 1869 dbSNP
rs1328876759 1875 dbSNP
rs941606158 1878 dbSNP
rs974332885 1880 dbSNP
rs1288646685 1882 dbSNP
rs1229843615 1883 dbSNP
rs1013544862 1896 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000336564.4 | 3UTR | GGCCGGUGGAUCACCUGAGGUCAGGAGUUUGAGACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000336564.4 | 3UTR | CGGUGGAUCACCUGAGGUCAGGAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000336564.4 | 3UTR | CGGUGGAUCACCUGAGGUCAGGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors -0.404 4.7e-4 -0.301 7.8e-3 64 Click to see details
GSE21849 B cell lymphoma -0.447 7.5e-3 -0.447 7.5e-3 29 Click to see details
GSE19783 ER- ER- breast cancer -0.196 4.2e-2 -0.232 2.0e-2 79 Click to see details
GSE28544 Breast cancer -0.338 5.3e-2 -0.261 1.1e-1 24 Click to see details
GSE14794 Lymphoblastoid cells -0.16 6.6e-2 -0.149 8.1e-2 90 Click to see details
GSE17498 Multiple myeloma -0.222 8.4e-2 -0.297 3.1e-2 40 Click to see details
GSE19536 Breast cancer -0.135 9.0e-2 -0.161 5.5e-2 100 Click to see details
GSE42095 Differentiated embryonic stem cells 0.272 1.0e-1 0.000 5.0e-1 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.291 1.1e-1 0.426 3.1e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.231 1.3e-1 -0.258 1.1e-1 25 Click to see details
GSE32688 Pancreatic cancer 0.192 1.5e-1 0.163 1.9e-1 32 Click to see details
GSE28260 Renal cortex and medulla -0.277 1.8e-1 -0.087 3.9e-1 13 Click to see details
GSE19350 CNS germ cell tumors 0.232 2.3e-1 0.252 2.1e-1 12 Click to see details
GSE19783 ER+ ER+ breast cancer 0.149 2.7e-1 -0.080 3.7e-1 20 Click to see details
GSE17306 Multiple myeloma -0.069 3.2e-1 -0.025 4.3e-1 49 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.095 3.3e-1 0.265 1.0e-1 25 Click to see details
GSE27834 Pluripotent stem cells -0.122 3.3e-1 -0.012 4.8e-1 16 Click to see details
GSE38226 Liver fibrosis -0.021 4.6e-1 -0.013 4.8e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.009 4.8e-1 -0.039 4.3e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.009 4.8e-1 -0.039 4.3e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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