pre-miRNA Information
pre-miRNA hsa-mir-378g   
Genomic Coordinates chr1: 94745860 - 94745900
Description Homo sapiens miR-378g stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-378g
Sequence 2| ACUGGGCUUGGAGUCAGAAG |21
Evidence Experimental
Experiments Illumina
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TIAL1   
Synonyms TCBP, TIAR
Description TIA1 cytotoxic granule associated RNA binding protein like 1
Transcript NM_001033925   
Other Transcripts NM_003252   
Expression
Putative miRNA Targets on TIAL1
3'UTR of TIAL1
(miRNA target sites are highlighted)
>TIAL1|NM_001033925|3'UTR
   1 GCCGGGACTCTAAAAAAAAATTGTAATTCATGATAGGCTTCGATTTCCTGTGACACTCTGAAGACATGAAAGTAGACATC
  81 GGAAAATGAAAATATTTATTTTAAAAATTGAAATGTTTGGAACCTTTAGCACAGATTTGCTTTGGTGAAGGACACGTGTC
 161 TTCTAGTTCTGCCTTTTTAAGTTTTTGTTCATGATGGATATGAACATGATTTTTCTTTATGTACAAAAACTAAAATAAAG
 241 TCAATAAAGACAATTCTGACTACAAATTTTGATATAATAGGAAAAATGGCTAATACATTTTGATTCTTAGATACTATTCC
 321 ATTTTTATCTTGCTGTTCAGTATTTTAACTCACTGTGTTTTTAAAAGAGCAAAAAAGGGAGGATCGTGAAAACCTGGGAA
 401 TCACATATAAGTTCATCCTGAATCCTGATACTCCCCTCCCCTTCCCTGAGGTGGACCACATTTGAAGTCAGCAGAGAAAA
 481 AGTGTGATATTCAGAAGAAATGCGTGATTTTGGAGTCGCTTTGGAGGAAATATTTTCTTTCTCTATGCCTAAAGAAACTG
 561 AAGCCAGACTGAAGTTTTGCACCCTAAAAAAGGAACAGCATTGTTTGAGTTACTTGAGCAAATGTTGGTGGTCCACGTTA
 641 AGACATATTTTTAAAACTTCCAAAAGTGTCGATTATTAAAATTGTAGTATTTTACATTTCATTTTGGGGGGAAATCCAAG
 721 TATGGTGTTTGTATTGAAGTCAGACAGTCATACTTGTGCTTTTACATGAAGTTTAAATGATACATATTGTAAATATTCAA
 801 TAACTACAGTGTTTAAAAAGCATGCTTCAACATAGAAGTAGCAGCAATGTAATTATTTGAAGTAACACTTAACACACTCC
 881 GCTGCATTGAATGCAGTGGATTGATCAGAATGTTAAGACTGACATTTCCAAGGTTGGCTACTATGTAAAATTAAAATTAC
 961 ACAAATTGTGCAGAAAAAGCCTTAATTTTAATTTCATACAATCTTTGATGCATTAGTATGTTCTAAAATGTCATTGGGAA
1041 TTAGTTTTTTGTTTTTGTTTTTTTTTTTTTTTTTTTTTGCTTTACATTACTTGGTATGTAAATACCTTGATTAAAACCTT
1121 GTAAACCAATTTCAAGGTTACTATAAGTTGTATAGTACAAGTGTTTTTTAAAAATCTTGGGGTGTTTTTAAAAATTAAGA
1201 TATATTTTGCCCAAGAATTTTTTTAACAAGATTGCTAAAAACATCTTATTTAGACACTTCAATGTACCAATTTATAATTG
1281 GATATTCAGTTTAAATAGTACACAGAGTTGTGGCTTTTATTTTCAATTAATTTTTTTCCTTGTGGGCAGTGTGCATGGTA
1361 TAATAAGCCTGAGCAGAGGCTTAAGTTGTATGTGTGCAGAGTTTGTAAAGGAATCAATTGGAAGATGCAGAAGACCGAGG
1441 TTTGCTTTCAAGGTATTTTTCAGGCTGTGTGGGTAAAATTTGCCTCAAATTTCTATCAAACAGGAATGTAAAATAGATAA
1521 AATCCTATGTATTTGAATTGTCAGAGCTAGGGAGTGCAAATGTTTTGGCAATGTATTCAAAATGCTGGCCTGGGCACCAA
1601 AGAGAAAATAGCCTTTTACAGTTACATAGTAAGATGCGATTAGTACCCACAAATTACTGTTTTCTAAACATTTGAAGTTT
1681 TACGATTAGCTTTAAAATAATGATTTTATAAATTGGTGGTCACAATAATTTTGGTATTACTTTCCTCCTTTTCCCACTTA
1761 GCAATATAGCCAAATGTATTCAACATAAAAATTCATAGGGTCTGAAATTCATAGCTGGGCCAAATTTTTTATGGCACCTT
1841 AGTTTTACCATAATGGTCATCTATTACACTCTTCTGTTATAAAATATACCCTTATTTCTTTTGTTTATAGTATCTTTGAG
1921 GAATGTTTTTGGAAAAGTTAATTTATATTTTATAGGGAGAACACTCAATAAATTATGTTAACTGTGCCCCCGAGTTAAAA
2001 ATTTTATGAGTATATGTGAAACTTGAACAACTGAAGACTTTTTTTAATTGATAAAAATGCTTAGTATGCCTGTTTTGGTC
2081 TGCCAGTAAATTAAGTAGCTTATTGAGATAACTAACAGCTAAATATAGCTGTAGTGTTTCCTGACTGTATATTCTATGAT
2161 TTAATAAAATTATCCAGACTAGTTATATTGCCACAGTAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaAGAC--UGAGGUUCGGGUCa 5'
            |:||  || :: ||| ||| 
Target 5' tgTTTGGAACCTTTAGCACAGa 3'
114 - 135 120.00 -11.10
2
miRNA  3' gaAGACUGAGGUUCGGGUca 5'
            |||  |||:| |||:|  
Target 5' ttTCTTTCTCTATGCCTAaa 3'
534 - 553 102.00 -13.80
3
miRNA  3' gaAGACUGAGGUUCGGGUCa 5'
            ||  | | | :|||::| 
Target 5' atTCAAAATGCTGGCCTGGg 3'
1575 - 1594 102.00 -8.92
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN2374677 12 COSMIC
COSN30718873 12 COSMIC
COSN30135461 41 COSMIC
COSN31601975 63 COSMIC
COSN31610579 80 COSMIC
COSN30519709 105 COSMIC
COSN18734778 116 COSMIC
COSN31587955 155 COSMIC
COSN30460673 173 COSMIC
COSN31546231 188 COSMIC
COSN30160887 208 COSMIC
COSN31521706 263 COSMIC
COSN26633368 367 COSMIC
COSN31577322 592 COSMIC
COSN31524109 688 COSMIC
COSN29788251 815 COSMIC
COSN30173218 819 COSMIC
COSN22337253 921 COSMIC
COSN16008512 1358 COSMIC
COSN23385571 1652 COSMIC
COSN29743262 1671 COSMIC
COSN15692018 1863 COSMIC
COSN16130388 2050 COSMIC
COSN1473654 2066 COSMIC
COSN29499576 2157 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs371811314 2 dbSNP
rs772511363 3 dbSNP
rs748683256 4 dbSNP
rs1419855207 9 dbSNP
rs745533594 12 dbSNP
rs756751746 12 dbSNP
rs1491272632 13 dbSNP
rs1280646828 16 dbSNP
rs1353477856 17 dbSNP
rs1208377798 18 dbSNP
rs73366847 20 dbSNP
rs746918865 20 dbSNP
rs200630840 21 dbSNP
rs777538092 21 dbSNP
rs371998825 23 dbSNP
rs1469309347 30 dbSNP
rs773689402 33 dbSNP
rs748747035 36 dbSNP
rs1182704036 37 dbSNP
rs1365398289 38 dbSNP
rs779714114 39 dbSNP
rs1039878816 41 dbSNP
rs755726615 42 dbSNP
rs750202071 50 dbSNP
rs781030286 51 dbSNP
rs937079808 60 dbSNP
rs1426355247 66 dbSNP
rs1220794813 71 dbSNP
rs942876799 77 dbSNP
rs190349256 78 dbSNP
rs1438197724 80 dbSNP
rs1338004224 95 dbSNP
rs1243298164 98 dbSNP
rs1315017125 108 dbSNP
rs1360592049 114 dbSNP
rs1248701995 120 dbSNP
rs1272750693 148 dbSNP
rs1051392344 156 dbSNP
rs1196395933 166 dbSNP
rs185036091 178 dbSNP
rs1331347073 179 dbSNP
rs1440588134 190 dbSNP
rs1186707705 191 dbSNP
rs767006818 195 dbSNP
rs1464642940 198 dbSNP
rs1243722876 203 dbSNP
rs1446211507 206 dbSNP
rs1353325675 224 dbSNP
rs1178837194 231 dbSNP
rs566873827 236 dbSNP
rs564146783 240 dbSNP
rs774047928 240 dbSNP
rs1424856505 242 dbSNP
rs1330378389 248 dbSNP
rs1399395243 253 dbSNP
rs966207366 259 dbSNP
rs918223056 274 dbSNP
rs772530282 281 dbSNP
rs1192013556 287 dbSNP
rs529335244 292 dbSNP
rs1454852235 302 dbSNP
rs1295876619 313 dbSNP
rs1441717125 316 dbSNP
rs1238873996 324 dbSNP
rs144276430 330 dbSNP
rs1253337060 332 dbSNP
rs1342926501 339 dbSNP
rs1203173482 340 dbSNP
rs1263673796 343 dbSNP
rs1456489771 344 dbSNP
rs1186386676 348 dbSNP
rs974157147 349 dbSNP
rs1019109014 352 dbSNP
rs1428941304 353 dbSNP
rs1194852253 355 dbSNP
rs941089145 373 dbSNP
rs1375640162 377 dbSNP
rs927068486 381 dbSNP
rs1176528240 385 dbSNP
rs953438343 386 dbSNP
rs376465689 388 dbSNP
rs1249587290 390 dbSNP
rs1361656534 391 dbSNP
rs11199023 394 dbSNP
rs1383176750 398 dbSNP
rs1212098884 399 dbSNP
rs748711274 403 dbSNP
rs1000166312 404 dbSNP
rs979892069 405 dbSNP
rs1284028101 406 dbSNP
rs1325543579 407 dbSNP
rs1206709007 410 dbSNP
rs1231627343 419 dbSNP
rs1355488554 433 dbSNP
rs1206748602 434 dbSNP
rs1486066553 434 dbSNP
rs540422720 435 dbSNP
rs1024640208 438 dbSNP
rs1014517962 440 dbSNP
rs1445459415 444 dbSNP
rs988710610 455 dbSNP
rs956164640 462 dbSNP
rs1471344603 467 dbSNP
rs1030979685 469 dbSNP
rs1226705956 481 dbSNP
rs578128907 503 dbSNP
rs779582945 504 dbSNP
rs868737729 507 dbSNP
rs1449338674 515 dbSNP
rs139632112 517 dbSNP
rs1172091249 518 dbSNP
rs1018406153 532 dbSNP
rs1284213575 533 dbSNP
rs1381217643 539 dbSNP
rs1226717248 541 dbSNP
rs1347444787 541 dbSNP
rs1048546290 545 dbSNP
rs1317454048 545 dbSNP
rs1417437296 546 dbSNP
rs1240852236 563 dbSNP
rs929620915 566 dbSNP
rs919523105 568 dbSNP
rs1007063841 589 dbSNP
rs766711922 594 dbSNP
rs1270653557 596 dbSNP
rs1483497230 607 dbSNP
rs146778667 625 dbSNP
rs866112702 628 dbSNP
rs944934275 628 dbSNP
rs182472972 630 dbSNP
rs773641173 636 dbSNP
rs773789171 637 dbSNP
rs1303973639 639 dbSNP
rs1367766493 645 dbSNP
rs555385867 646 dbSNP
rs527360362 649 dbSNP
rs1297696586 651 dbSNP
rs1373902563 660 dbSNP
rs1393096969 662 dbSNP
rs1310531969 663 dbSNP
rs941058045 667 dbSNP
rs1246515688 669 dbSNP
rs190195287 671 dbSNP
rs1314176705 675 dbSNP
rs979187935 685 dbSNP
rs979860903 688 dbSNP
rs1232986572 690 dbSNP
rs143589330 705 dbSNP
rs949811717 710 dbSNP
rs73366846 711 dbSNP
rs183824129 713 dbSNP
rs1164616091 715 dbSNP
rs1387255337 718 dbSNP
rs1408456659 726 dbSNP
rs1169775739 728 dbSNP
rs955965576 733 dbSNP
rs1033373199 734 dbSNP
rs979421360 741 dbSNP
rs1370272714 749 dbSNP
rs968082134 751 dbSNP
rs1001291542 766 dbSNP
rs539218530 770 dbSNP
rs888201165 786 dbSNP
rs1018292424 787 dbSNP
rs144383599 793 dbSNP
rs1308736541 799 dbSNP
rs1207498788 800 dbSNP
rs1261747338 806 dbSNP
rs1438804186 807 dbSNP
rs1048122298 825 dbSNP
rs994307391 831 dbSNP
rs1245385382 842 dbSNP
rs896840562 844 dbSNP
rs1185666752 860 dbSNP
rs1186122378 862 dbSNP
rs1006943013 864 dbSNP
rs1489168667 867 dbSNP
rs1041103536 871 dbSNP
rs750012803 875 dbSNP
rs550575916 877 dbSNP
rs1174374853 878 dbSNP
rs372483277 880 dbSNP
rs1266841439 881 dbSNP
rs1221740047 891 dbSNP
rs944972731 891 dbSNP
rs1320568895 896 dbSNP
rs1029805543 897 dbSNP
rs1429838969 914 dbSNP
rs1270406788 916 dbSNP
rs1363648440 926 dbSNP
rs879029995 930 dbSNP
rs994766147 932 dbSNP
rs1323405759 939 dbSNP
rs1204829577 941 dbSNP
rs191578959 942 dbSNP
rs781014441 943 dbSNP
rs1445620427 945 dbSNP
rs1277887345 949 dbSNP
rs757068922 953 dbSNP
rs1038622520 955 dbSNP
rs1215600675 958 dbSNP
rs1242849556 960 dbSNP
rs963176586 964 dbSNP
rs1380880864 985 dbSNP
rs1197300457 995 dbSNP
rs1428719311 999 dbSNP
rs1480833373 1000 dbSNP
rs905497373 1001 dbSNP
rs1393215099 1011 dbSNP
rs1050585695 1018 dbSNP
rs575591782 1020 dbSNP
rs1402755465 1023 dbSNP
rs879114031 1024 dbSNP
rs1302188801 1034 dbSNP
rs1332631492 1035 dbSNP
rs1457501578 1036 dbSNP
rs1345567480 1039 dbSNP
rs1321289245 1040 dbSNP
rs1389345623 1043 dbSNP
rs1439847862 1043 dbSNP
rs927472212 1044 dbSNP
rs1162736829 1045 dbSNP
rs1478731706 1048 dbSNP
rs1455251483 1049 dbSNP
rs200599058 1051 dbSNP
rs1349165882 1052 dbSNP
rs949806556 1052 dbSNP
rs1220511065 1053 dbSNP
rs917010101 1055 dbSNP
rs1490533090 1056 dbSNP
rs111740135 1057 dbSNP
rs1201692100 1057 dbSNP
rs369406993 1058 dbSNP
rs5788360 1058 dbSNP
rs1269086093 1060 dbSNP
rs1052945948 1061 dbSNP
rs1422564652 1061 dbSNP
rs560771367 1061 dbSNP
rs1280685139 1062 dbSNP
rs548960485 1062 dbSNP
rs1193447715 1063 dbSNP
rs1244323582 1063 dbSNP
rs1356281260 1063 dbSNP
rs529252152 1063 dbSNP
rs967849500 1064 dbSNP
rs978638690 1064 dbSNP
rs1162696399 1065 dbSNP
rs1385409168 1065 dbSNP
rs1442534901 1065 dbSNP
rs563224031 1066 dbSNP
rs796527757 1066 dbSNP
rs1249886169 1067 dbSNP
rs911194436 1067 dbSNP
rs1259833056 1068 dbSNP
rs1338808827 1068 dbSNP
rs1459933239 1069 dbSNP
rs574920715 1069 dbSNP
rs913271065 1069 dbSNP
rs993230290 1070 dbSNP
rs1372215876 1071 dbSNP
rs1467655888 1072 dbSNP
rs1169156801 1073 dbSNP
rs1270667274 1077 dbSNP
rs1202923560 1079 dbSNP
rs1228166505 1079 dbSNP
rs1280196972 1079 dbSNP
rs1293693955 1079 dbSNP
rs1321282831 1079 dbSNP
rs1326074828 1079 dbSNP
rs1336699465 1079 dbSNP
rs1398214497 1079 dbSNP
rs1403023021 1079 dbSNP
rs1407274142 1079 dbSNP
rs1468734965 1079 dbSNP
rs369013335 1079 dbSNP
rs376646404 1079 dbSNP
rs1302922520 1080 dbSNP
rs1426553144 1080 dbSNP
rs374704870 1080 dbSNP
rs1479854672 1082 dbSNP
rs1176323928 1084 dbSNP
rs1201076856 1091 dbSNP
rs1467837668 1091 dbSNP
rs540733236 1093 dbSNP
rs1251228879 1105 dbSNP
rs1383020025 1106 dbSNP
rs1300324055 1109 dbSNP
rs1343693879 1113 dbSNP
rs770451305 1119 dbSNP
rs1283774757 1121 dbSNP
rs1225756007 1136 dbSNP
rs1313894925 1139 dbSNP
rs955465636 1143 dbSNP
rs1030187687 1152 dbSNP
rs1486096797 1156 dbSNP
rs994339022 1160 dbSNP
rs1302278938 1164 dbSNP
rs1490041458 1166 dbSNP
rs1386381895 1171 dbSNP
rs1268594867 1175 dbSNP
rs1435444132 1179 dbSNP
rs1157322268 1180 dbSNP
rs961883118 1188 dbSNP
rs1017060024 1193 dbSNP
rs1034193325 1200 dbSNP
rs952520587 1202 dbSNP
rs1027213474 1203 dbSNP
rs1404348584 1208 dbSNP
rs1333374278 1209 dbSNP
rs1369593360 1215 dbSNP
rs1005729909 1226 dbSNP
rs1401016788 1227 dbSNP
rs113332929 1230 dbSNP
rs186775941 1238 dbSNP
rs1317284597 1242 dbSNP
rs1460311148 1243 dbSNP
rs1044022750 1262 dbSNP
rs564679648 1264 dbSNP
rs1040721084 1268 dbSNP
rs1379113253 1270 dbSNP
rs1199145855 1272 dbSNP
rs1266728715 1278 dbSNP
rs149651974 1283 dbSNP
rs895560365 1285 dbSNP
rs890729114 1289 dbSNP
rs1050637817 1295 dbSNP
rs1053317313 1296 dbSNP
rs1383568035 1302 dbSNP
rs926167084 1305 dbSNP
rs1165800891 1310 dbSNP
rs575997799 1321 dbSNP
rs556143268 1325 dbSNP
rs1297537396 1338 dbSNP
rs1373978223 1338 dbSNP
rs1448639929 1338 dbSNP
rs1457802054 1341 dbSNP
rs1312671373 1346 dbSNP
rs1381532689 1353 dbSNP
rs925740079 1355 dbSNP
rs1291639905 1374 dbSNP
rs1194540404 1375 dbSNP
rs1203288110 1379 dbSNP
rs541800949 1384 dbSNP
rs1251188650 1386 dbSNP
rs1042926626 1394 dbSNP
rs1458623942 1399 dbSNP
rs943246016 1402 dbSNP
rs1347602876 1412 dbSNP
rs1241653247 1415 dbSNP
rs913275361 1417 dbSNP
rs1233858218 1418 dbSNP
rs910497097 1432 dbSNP
rs1416318974 1436 dbSNP
rs985447390 1437 dbSNP
rs1311728615 1453 dbSNP
rs1400875662 1456 dbSNP
rs1467147738 1467 dbSNP
rs1334654410 1477 dbSNP
rs572806318 1484 dbSNP
rs955593848 1485 dbSNP
rs370401028 1494 dbSNP
rs1448554703 1495 dbSNP
rs748614868 1514 dbSNP
rs938663363 1523 dbSNP
rs376798288 1525 dbSNP
rs1213428265 1544 dbSNP
rs776620571 1546 dbSNP
rs980009549 1547 dbSNP
rs952625450 1548 dbSNP
rs1376215643 1554 dbSNP
rs1328136869 1559 dbSNP
rs867563933 1560 dbSNP
rs748894581 1571 dbSNP
rs1404091177 1572 dbSNP
rs1173010700 1573 dbSNP
rs961493043 1580 dbSNP
rs1017033859 1590 dbSNP
rs1233363280 1596 dbSNP
rs1005698557 1599 dbSNP
rs1392931399 1608 dbSNP
rs1239377495 1611 dbSNP
rs1485026992 1611 dbSNP
rs1185960596 1612 dbSNP
rs1160050117 1614 dbSNP
rs1424382044 1619 dbSNP
rs1478870893 1622 dbSNP
rs972942042 1624 dbSNP
rs970270573 1627 dbSNP
rs751316415 1628 dbSNP
rs1013918264 1629 dbSNP
rs961155082 1630 dbSNP
rs1429557520 1631 dbSNP
rs895429856 1637 dbSNP
rs1341823557 1638 dbSNP
rs552759798 1641 dbSNP
rs1031341107 1643 dbSNP
rs1444574241 1644 dbSNP
rs1019757337 1647 dbSNP
rs1257478577 1650 dbSNP
rs1220125637 1657 dbSNP
rs998979066 1664 dbSNP
rs904293508 1678 dbSNP
rs1042895885 1682 dbSNP
rs1484883671 1683 dbSNP
rs1007910929 1684 dbSNP
rs1264240521 1687 dbSNP
rs1489308777 1688 dbSNP
rs1288478558 1701 dbSNP
rs1197367389 1702 dbSNP
rs1268022384 1705 dbSNP
rs1478333724 1705 dbSNP
rs1174288454 1714 dbSNP
rs1405495897 1715 dbSNP
rs1399955894 1716 dbSNP
rs1158873418 1720 dbSNP
rs539544095 1722 dbSNP
rs943213537 1723 dbSNP
rs1350074604 1725 dbSNP
rs866873938 1729 dbSNP
rs1302016720 1733 dbSNP
rs1330986128 1735 dbSNP
rs764022194 1745 dbSNP
rs1247078566 1747 dbSNP
rs1371611579 1754 dbSNP
rs1239961437 1760 dbSNP
rs1052156456 1761 dbSNP
rs996470089 1764 dbSNP
rs1220299279 1766 dbSNP
rs1291094247 1767 dbSNP
rs570483829 1770 dbSNP
rs1413981159 1776 dbSNP
rs933255186 1785 dbSNP
rs1231174771 1792 dbSNP
rs1469380415 1795 dbSNP
rs1179042200 1796 dbSNP
rs557105103 1797 dbSNP
rs1373347127 1800 dbSNP
rs922561655 1805 dbSNP
rs1162577099 1811 dbSNP
rs1299674118 1812 dbSNP
rs972772278 1818 dbSNP
rs762739223 1833 dbSNP
rs184269779 1850 dbSNP
rs904766548 1860 dbSNP
rs909998057 1863 dbSNP
rs754006863 1871 dbSNP
rs1473487369 1873 dbSNP
rs1446431105 1879 dbSNP
rs1043238577 1880 dbSNP
rs984245682 1884 dbSNP
rs3009878 1889 dbSNP
rs1023090563 1891 dbSNP
rs993451834 1898 dbSNP
rs1265734677 1908 dbSNP
rs548085380 1911 dbSNP
rs535422448 1912 dbSNP
rs866219002 1917 dbSNP
rs1057117635 1919 dbSNP
rs938756611 1920 dbSNP
rs1442595298 1924 dbSNP
rs1182579566 1927 dbSNP
rs1368747996 1931 dbSNP
rs1473454667 1939 dbSNP
rs1165664113 1953 dbSNP
rs960330448 1962 dbSNP
rs766364178 1966 dbSNP
rs1332687990 1974 dbSNP
rs1282405929 1976 dbSNP
rs927334058 1977 dbSNP
rs980062123 1978 dbSNP
rs931253276 1979 dbSNP
rs1211761730 1991 dbSNP
rs566880181 1992 dbSNP
rs35272527 2002 dbSNP
rs1317411869 2008 dbSNP
rs904262219 2015 dbSNP
rs546706033 2016 dbSNP
rs961472451 2028 dbSNP
rs1021419665 2030 dbSNP
rs1007397786 2036 dbSNP
rs1443807598 2046 dbSNP
rs558082800 2046 dbSNP
rs953774089 2046 dbSNP
rs1431198684 2048 dbSNP
rs1344302404 2053 dbSNP
rs1315765519 2058 dbSNP
rs1371976585 2059 dbSNP
rs888913291 2062 dbSNP
rs1172008471 2068 dbSNP
rs1051612453 2072 dbSNP
rs533449566 2079 dbSNP
rs1000500974 2080 dbSNP
rs1403136408 2082 dbSNP
rs933205404 2083 dbSNP
rs768752988 2092 dbSNP
rs1022272661 2093 dbSNP
rs1037426801 2094 dbSNP
rs940057953 2101 dbSNP
rs1460286190 2103 dbSNP
rs1400763541 2108 dbSNP
rs1279945397 2110 dbSNP
rs1426404148 2115 dbSNP
rs139348603 2116 dbSNP
rs1194917447 2117 dbSNP
rs1321349235 2119 dbSNP
rs909966819 2126 dbSNP
rs1232197215 2130 dbSNP
rs1475278345 2132 dbSNP
rs1346921523 2139 dbSNP
rs984129688 2158 dbSNP
rs1262105242 2174 dbSNP
rs557330763 2186 dbSNP
rs11813471 2193 dbSNP
rs1488292376 2195 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000369093.2 | 3UTR | CAGCCAACAUGGUGAAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
68 hsa-miR-378g Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT444739 SMYD1 SET and MYND domain containing 1 2 2
MIRT456104 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT458683 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT465802 TMEM91 transmembrane protein 91 2 2
MIRT470843 PLXND1 plexin D1 2 2
MIRT497263 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497674 SYNGR1 synaptogyrin 1 2 2
MIRT498218 TLN2 talin 2 2 2
MIRT498309 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504046 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT518196 CLEC4E C-type lectin domain family 4 member E 2 2
MIRT533143 WNT10A Wnt family member 10A 2 2
MIRT533540 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533679 TMEM86A transmembrane protein 86A 2 2
MIRT540892 SRSF9 serine and arginine rich splicing factor 9 2 2
MIRT541329 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT541850 PLIN5 perilipin 5 2 2
MIRT551431 F2 coagulation factor II, thrombin 2 2
MIRT552105 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564912 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568605 ACVR2A activin A receptor type 2A 2 2
MIRT572604 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT574234 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT575688 Map1b microtubule-associated protein 1B 2 2
MIRT576643 Mill2 MHC I like leukocyte 2 1 1
MIRT609877 RAD54L2 RAD54 like 2 2 4
MIRT610057 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610791 KLK2 kallikrein related peptidase 2 2 2
MIRT617175 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT617707 RUSC2 RUN and SH3 domain containing 2 2 2
MIRT620577 WBSCR27 methyltransferase like 27 2 4
MIRT622657 POU2F3 POU class 2 homeobox 3 2 4
MIRT624561 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT634255 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT634677 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT635254 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637081 SELPLG selectin P ligand 2 2
MIRT639021 AAK1 AP2 associated kinase 1 2 2
MIRT640396 ZNF785 zinc finger protein 785 2 2
MIRT642441 CLUAP1 clusterin associated protein 1 2 2
MIRT645666 ADK adenosine kinase 2 2
MIRT646083 MGST3 microsomal glutathione S-transferase 3 2 2
MIRT650513 UFM1 ubiquitin fold modifier 1 2 2
MIRT652474 TMEM181 transmembrane protein 181 2 2
MIRT652584 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654763 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT655200 PHAX phosphorylated adaptor for RNA export 2 2
MIRT658353 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT661820 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT662190 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT664375 CYB5A cytochrome b5 type A 2 2
MIRT665025 ELK1 ELK1, ETS transcription factor 2 2
MIRT666492 SBNO1 strawberry notch homolog 1 2 2
MIRT668480 EXOSC2 exosome component 2 2 2
MIRT682768 TMEM120B transmembrane protein 120B 2 2
MIRT689628 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT691846 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT696490 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT712480 FSTL3 follistatin like 3 2 2
MIRT712780 ZNF154 zinc finger protein 154 2 2
MIRT716607 MPPED1 metallophosphoesterase domain containing 1 2 2
MIRT719357 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT719739 SLC39A11 solute carrier family 39 member 11 2 2
MIRT722569 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722838 C17orf102 chromosome 17 open reading frame 102 2 2
MIRT733138 LINC00963 long intergenic non-protein coding RNA 963 3 0
MIRT733139 CHI3L1 chitinase 3 like 1 3 0
MIRT736944 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-378g Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (500nM)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-378g Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib + Trametinib sensitive High Melanoma cell line
hsa-miR-378g Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line
hsa-mir-378g Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-378g Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-378g Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-378g Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-378g Tripterygium wilfordii Hook F resistant tissue
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-378g Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-378g Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-378g Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-378g Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-378g Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

Error report submission