pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PRR15L   
Synonyms ATAD4
Description proline rich 15 like
Transcript NM_024320   
Expression
Putative miRNA Targets on PRR15L
3'UTR of PRR15L
(miRNA target sites are highlighted)
>PRR15L|NM_024320|3'UTR
   1 AGGGCTGAGGAGGGTGCTAGCACCTCTTGGCTCCCTGCCATCAGCCAGATCTGAGACAGGACCTTGCCACGCTGGCCTCT
  81 TTGGCCATAGCTGAAGCTGTGGGGCCAGTTGATACCTGCTGGCAGGAAATGGCTGTTTTTTAGGTTTGTATTTATGTGCC
 161 GCCACTTTTGTAAGGCCTGGGAGATCCCAGGGTCCTCCACCCTCCCCCTGACCACATACAAAGGCACTCTAGTTCAAGAG
 241 TGAAAAGTCTCACCCAGGAGGAACAGCCCTCCTTGAAGCAATGGCAGGGCCAGCAGGGAGGTGGGCATGGCAGGGAATGG
 321 AGAGAGTGAGCCAGACAGACTTCACCTCCTTACTGGACACAGGGTCAAGGGCGAGTTTCAATTGCTGCTCCCTTTACTTT
 401 CTCTACCTGTGACTACTCCCTGGACCAATCCTGAGGAGGGCACATTTTCCAGAAGCCACGTGATAGGGGCTGGTTTCTGT
 481 GGAGCCAGAGGCAGAGACACTGAACTTGAGCTCACCTCCTAACACCGGCAGTAAACTTCCTGGAACTTTGCCCTCAGGTG
 561 CGGAGGGGACAGAGGACCCTGGCACTCTGTTAGGGTGCTGTAGAAGACTAGATTGATGGTAGTTTGGCCTGTTAGTTCCT
 641 GTTTTGGCCATGACTTTTGCAGATGGCAAGTCACACACCCTCAAAGGGAAGCTACACGGGCCAAATCGGGGGAGTGGGTG
 721 GGGAATTTTCTCCTCTCCCTTTCCTACTATAATAGTATTTAAGACATATCAGCTCCAGAGATGAGTCCTGGAGCCTTGAA
 801 TTTTGTTTAACAAAATAATTGTAGGTTTCTCTCTGTAATAACAACGCTGGAAAGGCAGAGAACCTCTTTTATGCTCATGT
 881 CTTGCATTTATTGAGATGACTGTTTCTCATGCCTTTATGTTCCTTCATGTAAGTAAAGTGGACCTTTGTGCTCAAAAAAA
 961 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgguuCCCUUACCGUCCCUUua 5'
               ||| |||||||||||  
Target 5' gaggtGGGCATGGCAGGGAAtg 3'
298 - 319 157.00 -23.80
2
miRNA  3' cgGUUCCCUUA-CCGUCCCUUua 5'
            |::||||:| ||::|||||  
Target 5' atCGGGGGAGTGGGTGGGGAAtt 3'
705 - 727 140.00 -28.20
3
miRNA  3' cgguucccuuaccgUCCCUUUa 5'
                        ||||||: 
Target 5' tcacacaccctcaaAGGGAAGc 3'
671 - 692 124.00 -10.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24314426 26 COSMIC
COSN19142927 42 COSMIC
COSN30155881 53 COSMIC
COSN31491964 59 COSMIC
COSN30105605 64 COSMIC
COSN16508306 73 COSMIC
COSN32058055 239 COSMIC
COSN20114076 320 COSMIC
COSN16048296 329 COSMIC
COSN7436859 411 COSMIC
COSN14629699 494 COSMIC
COSN7436858 510 COSMIC
COSN16569748 867 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs764104962 3 dbSNP
rs763029607 9 dbSNP
rs369594537 14 dbSNP
rs1372325612 15 dbSNP
rs1387198974 17 dbSNP
rs765183128 18 dbSNP
rs965942436 20 dbSNP
rs1345589338 21 dbSNP
rs759675827 26 dbSNP
rs776652991 29 dbSNP
rs1274649605 38 dbSNP
rs771249774 39 dbSNP
rs574114843 40 dbSNP
rs377077494 41 dbSNP
rs772533280 45 dbSNP
rs1343699232 63 dbSNP
rs1017533037 68 dbSNP
rs193177482 70 dbSNP
rs376913058 71 dbSNP
rs1192186894 75 dbSNP
rs1300986097 83 dbSNP
rs968101705 87 dbSNP
rs187403660 90 dbSNP
rs1037381222 106 dbSNP
rs16949737 107 dbSNP
rs558514445 115 dbSNP
rs538816572 120 dbSNP
rs1009692500 125 dbSNP
rs1431765573 126 dbSNP
rs892587447 127 dbSNP
rs1035191925 135 dbSNP
rs141917419 136 dbSNP
rs1430021932 138 dbSNP
rs908104588 141 dbSNP
rs775471983 155 dbSNP
rs149647449 160 dbSNP
rs1440009356 161 dbSNP
rs1298315567 181 dbSNP
rs1366738883 183 dbSNP
rs1212334121 198 dbSNP
rs933495475 199 dbSNP
rs138373764 200 dbSNP
rs1435133490 202 dbSNP
rs974815178 204 dbSNP
rs1012575137 207 dbSNP
rs1467426006 210 dbSNP
rs1213599793 215 dbSNP
rs1249262385 232 dbSNP
rs1476413255 233 dbSNP
rs1184902910 237 dbSNP
rs2875735 239 dbSNP
rs34428844 247 dbSNP
rs1411361373 256 dbSNP
rs76075050 260 dbSNP
rs966706430 261 dbSNP
rs1321106383 293 dbSNP
rs1390809951 298 dbSNP
rs1476527969 305 dbSNP
rs796141360 319 dbSNP
rs1020145904 320 dbSNP
rs113526912 323 dbSNP
rs35883535 323 dbSNP
rs1010605803 324 dbSNP
rs869273978 324 dbSNP
rs3047616 327 dbSNP
rs66537807 327 dbSNP
rs747539184 327 dbSNP
rs764809350 331 dbSNP
rs1291117115 336 dbSNP
rs1333140980 338 dbSNP
rs1269293323 346 dbSNP
rs1449185194 357 dbSNP
rs1486274498 360 dbSNP
rs895648705 361 dbSNP
rs1241537760 366 dbSNP
rs986040751 372 dbSNP
rs758776860 387 dbSNP
rs530637752 390 dbSNP
rs1190331200 393 dbSNP
rs1416012102 398 dbSNP
rs1035937080 403 dbSNP
rs1159565394 409 dbSNP
rs915247058 411 dbSNP
rs1273903438 418 dbSNP
rs748035894 421 dbSNP
rs1317573474 428 dbSNP
rs988595481 430 dbSNP
rs956823239 433 dbSNP
rs1310661658 435 dbSNP
rs528841255 438 dbSNP
rs1228645613 441 dbSNP
rs1001259171 450 dbSNP
rs533821339 452 dbSNP
rs1035160691 460 dbSNP
rs1289308093 461 dbSNP
rs1003695702 467 dbSNP
rs969573040 470 dbSNP
rs1338464666 473 dbSNP
rs552555888 477 dbSNP
rs1213175806 478 dbSNP
rs1255521444 491 dbSNP
rs1485445111 496 dbSNP
rs1183168065 497 dbSNP
rs772284632 497 dbSNP
rs1005840151 498 dbSNP
rs1378329247 505 dbSNP
rs1037476452 508 dbSNP
rs941662691 515 dbSNP
rs1300931751 518 dbSNP
rs1048729004 526 dbSNP
rs748322919 527 dbSNP
rs1374350696 530 dbSNP
rs993624839 530 dbSNP
rs897592544 537 dbSNP
rs1309537265 543 dbSNP
rs748268103 546 dbSNP
rs1048004985 547 dbSNP
rs933570237 551 dbSNP
rs779336852 561 dbSNP
rs183404299 562 dbSNP
rs975328945 563 dbSNP
rs943444688 568 dbSNP
rs1237186214 570 dbSNP
rs1278204092 579 dbSNP
rs376932932 582 dbSNP
rs1347260648 601 dbSNP
rs1477339526 606 dbSNP
rs573083973 611 dbSNP
rs1050264647 613 dbSNP
rs1180879556 618 dbSNP
rs946660581 630 dbSNP
rs915196727 634 dbSNP
rs1475859983 635 dbSNP
rs1393947410 640 dbSNP
rs979515530 656 dbSNP
rs1169257361 671 dbSNP
rs1393945082 692 dbSNP
rs956945094 697 dbSNP
rs530656864 698 dbSNP
rs1328554526 699 dbSNP
rs1180489622 707 dbSNP
rs1481793682 708 dbSNP
rs966675157 712 dbSNP
rs779099995 714 dbSNP
rs1233695044 720 dbSNP
rs543128024 721 dbSNP
rs928020245 723 dbSNP
rs529724738 728 dbSNP
rs35611198 730 dbSNP
rs560576757 730 dbSNP
rs1316269009 735 dbSNP
rs1195471584 739 dbSNP
rs982225478 747 dbSNP
rs1421393873 752 dbSNP
rs769059739 753 dbSNP
rs1469698365 762 dbSNP
rs1211741712 771 dbSNP
rs540618129 777 dbSNP
rs1321052374 780 dbSNP
rs1449523785 786 dbSNP
rs1194637351 787 dbSNP
rs1310431293 810 dbSNP
rs1474838959 811 dbSNP
rs1035502864 821 dbSNP
rs1163496730 825 dbSNP
rs1392954512 827 dbSNP
rs1395653956 829 dbSNP
rs572287394 831 dbSNP
rs755296345 839 dbSNP
rs749654140 845 dbSNP
rs1006184150 846 dbSNP
rs905720889 847 dbSNP
rs754079049 856 dbSNP
rs3096 857 dbSNP
rs1297761641 858 dbSNP
rs1027710320 860 dbSNP
rs190847382 864 dbSNP
rs1285078870 870 dbSNP
rs576202760 872 dbSNP
rs1336640782 880 dbSNP
rs1231281793 911 dbSNP
rs1396222848 919 dbSNP
rs541824916 920 dbSNP
rs115159645 923 dbSNP
rs1047856590 929 dbSNP
rs1258987696 932 dbSNP
rs537572684 936 dbSNP
rs1187809221 944 dbSNP
rs1008642922 950 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccuuaccGUCCCUUUa 5'
                       :||||:|| 
Target 5' ------------cUAGGGGAAa 3'
1 - 10
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000300557.2 | 3UTR | CUAGGGGAAAAAAAAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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