pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol PLA2G12A   
Synonyms GXII, PLA2G12, ROSSY
Description phospholipase A2 group XIIA
Transcript NM_030821   
Expression
Putative miRNA Targets on PLA2G12A
3'UTR of PLA2G12A
(miRNA target sites are highlighted)
>PLA2G12A|NM_030821|3'UTR
   1 AGGAGATGCCGACAGCTAGTGACAGATGAAGATGGAAGAACATACCTTTGACAAATAACTAATGTTTTTACAACATAAAA
  81 CTGTCTTATTTTTGTGAAAGGATTATTTTGAGACCTTAAAATAATTTATATCTTGATGTTAAAACCTCAAAGCAAAAAAA
 161 GTGAGGGAGATAGTGAGGGGAGGGCACGCTTGTCTTCTCAGGTATCTTCCCCAGCATTGCTCCCTTACTTAGTATGCCAA
 241 ATGTCTTGACCAATATCAAAAACAAGTGCTTGTTTAGCGGAGAATTTTGAAAAGAGGAATATATAACTCAATTTTCACAA
 321 CCACATTTACCAAAAAAAGAGATCAAATATAAAATTCATCATAATGTCTGTTCAACATTATCTTATTTGGAAAATGGGGA
 401 AATTATCACTTACAAGTATTTGTTTACTATGAAATTTTAAATACACATTTATGCCTAGAAGGAACGGACTTTTTTTTTCT
 481 ATTTTAATTACACATAATATGTAATTAAAGTACAACATAATATGTTGTTTCTCTGTAGCCCGTTGAGCATATGAGTAAGT
 561 CACATTTCTATTAGGACTACTTACAAGGACAAGGTTTCCATTTTTCCAGTTGTAAAATTGGAACCATCAGCTGATAACCT
 641 CGTAGGGAGCAACCCCAGGATAGCTAAGTGTTATGTAATATGCCTAGAAGGTGATGTGAATGCGATTCAGAAGCATAGCC
 721 ACTCCCATTTTATGAGCTACTCACATGACAAATGTCATCTTTTGCTATAACCTTTGCCAAGTTAGAGAAAAGATGGATTT
 801 AATGAGATAAATGAAAAGATATTTAACCTAATATATCAAGGCACTATTTGCTGTTATGCTTTGTTATTTATTTCCCAGCA
 881 CTTGTTCCTTATTGTAGATTTTTTAAAGACTGTAACCTTTTACTAACTGTGGTCTTACTAAAATTTGTGCTTGATACTGC
 961 TTTTCAAAAAGCCTTTAATTAGAGCCAAAAGGATGGAAAAGGCAAGATATAAATGCCTTTTATAGATCTCTTATTTACAT
1041 TGAAAATTATTACCATATGTTTAGAGCAAATCCAAGAAAACTTCAACAGCTTCTGAAGATGTCTATGAATGTTGAAAACT
1121 TTTCAATCTCTTGGAATGCTCAGTTATGTTCCTAGACCGGTCTTTGCTGACTACTGGTTGTTAACCTTTCCCTAGCCTGG
1201 GACCTCAAGCCATATATATCCTTTGGGTGACCCATGGCCAAAGTTATTAAGATGAACTGACTTTCAAAGTCAGAGAAGGA
1281 CAGCATAGGGAGAGGCGGTTATTTGTAAGTCATTACAGGTAGAACAGGGCAGAAGGAAAAGTATGTTCTGGAGAAAGGGC
1361 CATGTTCCTAACTTTGGAGATATGTCATTGCCGGGAACCTAGTATCTTCCAACTTGAATTGGTGGCAGCTGTTCCAGTGA
1441 GACAAGGCACATGTATGCCTTGTGGCTAAGTGAGCAAACTGGGTTTCCACTTAAATGTTTGGGACCCTCAATTGATTCTT
1521 TATTTCAAACCTTTATAAAAGGTACAGTTTTGTAAGCCATTATTAATAATTAATGCTTATCGGCTGGGCACAGTGGCTCA
1601 CACCTATAATCCCAGCACTTTGGGAGGCTGAGGCGGTTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCTGGCCAACAT
1681 GGTGAAACAGCGTCTCTACTAAAAATACAAAAATTTGCCGGGCGTGGTGGCGCATGCTTATAGTCTCAGCTACTCAGGAA
1761 GCTGAGGTACGAGAATCACTTGAACCCAGGAGGTGGAGGTTGCAGTGAGCTGAGATTGTGCCACTGCACTGCAGCCTGGG
1841 CAACAGAGCAAGACTCTAAAAAAAAAATGGTTTATCAATATTTACTATTGAAATATTTGTCCAGGTAACTTTACACTTAC
1921 AATGAATTCATGGATTTTGTTAGCAGCATTGGCTTTCTCAAAAGGACAAACTCAATATCGTTATAAAATATAATTCGTGA
2001 TCACAAATTATACAAAAATCAGTAGAAACAGTTTTTTATGTTCAGATTAAAAAAAAAAACTTGGGATAATTTTAGATTTA
2081 CAGAAAAGTTGCAAAGATACATGGAGAGCTTCTGTGACCACTCACCCAGTTCCCCCAGTGTTAACCTTTTATTTAACCAT
2161 GAAGCATTTGTCAGAAGCTAAGTAACCAGCAATGGCAATTACTATTAACGGAACTTTGACTTTATTTTTCAGATTGTACT
2241 AGTTTTTTAATTAATGTCATTTTTCTTTTCCAGGATCCAATCTAGGATACCACACTGAATTAGTCGTCATGCCTAATTAG
2321 CCTCTGGTCTGTGATAGTTCCACAGTCTTTCTTTTTCATAACCTTGACAGTTTTGAGGAGTACTGGTCAGGTGTTTTGTA
2401 GAATATTCCTCAATTTGGGTTTGTCTGATGTTTTCCTCATGGTTAGAGTGGGGTTATAGATTTTTAGGAAGAATACCAGA
2481 GGTGAAGGTCCTTCTCACTGCATCATGTCAGGAGTTACATGCTATCAGCTTGATGGTGTATTAACTTTGGACACTTGGTT
2561 AAGGTAGTGTGTGTTGGTTTTTTGCTGCTGAAAATTACTGTTATTTTCCCTTTCCATACTTCTGTTCTTTGGAAAACAGT
2641 CACTAAGTCCAGTCATGGGAGGTGGTGGGTGGGAAAGATTACATTCAACCCCCTGGAAGTGGGAATATCCATATGTAGTA
2721 TTTGGAATTTTTCTATATGGAAAATTTGTTTCTCCCTCCCACCCTAATTTGTTTACATCAGTATGGACTCATGTATATTT
2801 TGTATTTTGGGTAACACAGTATTTATTTTGTTGCTTAAGTTGTCCAGCTTGGCTATTAGGAGTTCTGCCAGGTTGGCTAC
2881 TATGTCCCTTTGATGTGCCCATCCTTTTGATTTTTGAGCACTTCTTACTTTCTGGCACTACAAGATGCTCCAGGTTCATC
2961 TTGGATATTCCCTGCCCCAACCCTAGAATCCCTAGAATCAACCCCTGCTCCAAAGAGCCCTGGTTCCTTTTGTTGGAGAA
3041 TCATACTTAGAAACCAAGATCTGGGCATTAGATGTGCTTGTTGCTACTGGGATGTCACTGTTTGTAGCAGAGTTGAGAAA
3121 TATGTATGTATATTAATCCATGCATATGTACACATCTATAATTATTTATGTGTGTACAAAGCTAAACATGAGTTTGTACT
3201 GCCGTCTTCAACTCAAAATTTGTCCCAAAATTTTGTGGCATATGTTTAGATTTTAAAGTTGATATTTTCCCTATTGACAG
3281 AATAAACTCATTAAAAGAGCAAAAAAAAAAAAAAAAAAAAAAAGGCAAGAACTAACTGTCAGCAGCTCTTTGCAAGAAAT
3361 GTAATATTGATACTTTAAAATAATACTGCCTTCAAATGATGCCTGTCTCTTTAAAATCTTTTGACATAGTTCTTCCAGGG
3441 ACAGATATGGCTGTATTTATTTCATAGATGGAGAAACTGAGCACAGAGCTGTAATGAAGACAGAATTGAGATATAAGGGC
3521 AAAAGCTAATTAAACGCATCCTCACAGGTAGCCTTTCTTTCAGTGAACCTGTAGACTAGTCCAGTAATACTTATTAAAAT
3601 TAGTTGTTAGAGGCTGGGCATGGTGGTTCAAGCCTGTAATCTCAGCACTGTGGGAGGCCAAGGCGGACAGATCACTCAAA
3681 GTCAGAAGTTCGAGACCAGCTTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAATACAAAAATTAGTTGGGTGTGGTG
3761 GCACATGCCTGTAATCCCAGCCACTCGGGAGGTGAAGGCACAAGAATTGGTTGAACCTGGGAAGCAGAGGTTGCAGTGAG
3841 CTGAGATTGCACTGCTGCACTCCAGCATAGGCGTCAGAATAAGACTCTGTCTTGGAAAGAAGAAAAAAAATTGTTAGCCT
3921 AAAACCAACTCTCTCTAAATTTAAAAGAGTGATTATTTATCTTAGTATTTATAGAAGTATGAGATTATCAGAAGGTGCGA
4001 TGCACAATGCTCATTATTTTATCCTAGTACAAGACACGTATAACATCTAACAGTAAAGAAGATGGAATCTTTCTATAAAA
4081 ACAATTCTGTTATTAATAGTTGACTGACTTCAGTAACTTTGAGGAGTAGAATGAAACTTATTAGGCAAGATCTTTCCACA
4161 TACACTACATTGTATTGTTCAAAATTCATAGAAATTACTTGCAATATATTGATTTAAGCCTTATGTAGTGACTGTTGCTA
4241 TATTTGAAGTAGCATTTTTAGTTTGCTGTTTTTCCTCACTGCTTAATCCTACAAAAACCAGCCATCTGCCTAAAAAATAA
4321 AAGAGCAAAAATGAATCAGTGCAACCGGTATACGAAAAATAATAATTATTAATAAAACTGTAAAGGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agugUCAACG---GUCGACUCUAAu 5'
              :|||||    |||||||||| 
Target 5' tggaGGTTGCAGTGAGCTGAGATTg 3'
1794 - 1818 166.00 -20.70
2
miRNA  3' agugUCAACG---GUCGACUCUAAu 5'
              :|||||    |||||||||| 
Target 5' cagaGGTTGCAGTGAGCTGAGATTg 3'
3825 - 3849 166.00 -20.70
3
miRNA  3' agugucaacggUCG-ACUCUAAu 5'
                     ||: ||||||| 
Target 5' gtatttatagaAGTATGAGATTa 3'
3965 - 3987 143.00 -11.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN17132600 4 COSMIC
COSN26989266 8 COSMIC
COSN26989265 9 COSMIC
COSN30486504 11 COSMIC
COSN17154198 43 COSMIC
COSN30193833 53 COSMIC
COSN30456597 65 COSMIC
COSN30150487 124 COSMIC
COSN7723770 126 COSMIC
COSN30168541 137 COSMIC
COSN30150343 148 COSMIC
COSN18729010 154 COSMIC
COSN31521881 220 COSMIC
COSN31542401 266 COSMIC
COSN29122386 278 COSMIC
COSN9584282 659 COSMIC
COSN22828182 675 COSMIC
COSN5050662 1195 COSMIC
COSN5151196 1257 COSMIC
COSN32058643 1271 COSMIC
COSN22115809 1386 COSMIC
COSN15661503 1395 COSMIC
COSN22547568 1417 COSMIC
COSN26740437 1729 COSMIC
COSN22292903 1740 COSMIC
COSN29531943 1857 COSMIC
COSN25609165 2010 COSMIC
COSN16904844 2011 COSMIC
COSN29069461 2048 COSMIC
COSN27517847 2049 COSMIC
COSN24692438 2386 COSMIC
COSN31575609 2411 COSMIC
COSN17675657 2577 COSMIC
COSN1979511 3020 COSMIC
COSN5548711 3046 COSMIC
COSN25605784 3112 COSMIC
COSN25395154 3382 COSMIC
COSN20329325 3513 COSMIC
COSN22584604 3536 COSMIC
COSN7723769 3917 COSMIC
COSN25814027 3928 COSMIC
COSN9584281 3999 COSMIC
COSN27786285 4037 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1365108484 6 dbSNP
rs1382201892 9 dbSNP
rs376897037 11 dbSNP
rs748337330 13 dbSNP
rs781267331 14 dbSNP
rs1163653650 15 dbSNP
rs755145700 16 dbSNP
rs1371276315 19 dbSNP
rs1195153098 20 dbSNP
rs374032077 24 dbSNP
rs369693715 25 dbSNP
rs1460341374 33 dbSNP
rs376672253 40 dbSNP
rs1260735912 41 dbSNP
rs529301019 45 dbSNP
rs57182211 45 dbSNP
rs998104612 45 dbSNP
rs1490748142 46 dbSNP
rs1290088449 48 dbSNP
rs1195602625 49 dbSNP
rs1430101029 50 dbSNP
rs750270543 50 dbSNP
rs765070003 51 dbSNP
rs901061265 52 dbSNP
rs1416886218 55 dbSNP
rs1018901724 60 dbSNP
rs1307796844 61 dbSNP
rs1007490116 64 dbSNP
rs901051724 66 dbSNP
rs889210612 73 dbSNP
rs1049133416 82 dbSNP
rs930831779 83 dbSNP
rs897993428 101 dbSNP
rs1387701073 114 dbSNP
rs199818158 120 dbSNP
rs1293104745 123 dbSNP
rs143438357 124 dbSNP
rs942472135 146 dbSNP
rs1367969441 150 dbSNP
rs889492024 159 dbSNP
rs1048075969 161 dbSNP
rs930998083 161 dbSNP
rs553696289 163 dbSNP
rs1404780634 170 dbSNP
rs939591581 172 dbSNP
rs1486843260 180 dbSNP
rs1179091551 184 dbSNP
rs140983244 188 dbSNP
rs1157643112 189 dbSNP
rs980452438 203 dbSNP
rs1471724023 204 dbSNP
rs947674257 211 dbSNP
rs1190367805 221 dbSNP
rs1181146085 223 dbSNP
rs1159997284 235 dbSNP
rs771545910 238 dbSNP
rs574525610 240 dbSNP
rs1433457449 242 dbSNP
rs1450929956 252 dbSNP
rs546996430 253 dbSNP
rs1376478500 267 dbSNP
rs914998345 277 dbSNP
rs940917187 278 dbSNP
rs1370806675 279 dbSNP
rs1222850189 292 dbSNP
rs928163360 303 dbSNP
rs1318171912 305 dbSNP
rs982650145 307 dbSNP
rs1279469847 311 dbSNP
rs1348326997 318 dbSNP
rs1293798652 324 dbSNP
rs1230948885 325 dbSNP
rs989241877 334 dbSNP
rs749767057 336 dbSNP
rs1177975971 337 dbSNP
rs1030839330 338 dbSNP
rs1252784511 341 dbSNP
rs976950858 343 dbSNP
rs1173570881 347 dbSNP
rs965281546 362 dbSNP
rs1396154770 364 dbSNP
rs1437113356 368 dbSNP
rs1018117252 371 dbSNP
rs1007545751 375 dbSNP
rs200598772 375 dbSNP
rs1320523798 376 dbSNP
rs969518944 377 dbSNP
rs1284345338 381 dbSNP
rs916623596 390 dbSNP
rs1326618220 399 dbSNP
rs1287372141 406 dbSNP
rs1405892629 414 dbSNP
rs889099735 415 dbSNP
rs1030957554 419 dbSNP
rs554523182 421 dbSNP
rs1205527744 422 dbSNP
rs190362320 422 dbSNP
rs1346365489 425 dbSNP
rs897871857 429 dbSNP
rs1455994745 430 dbSNP
rs1036535982 441 dbSNP
rs939477220 446 dbSNP
rs569349188 451 dbSNP
rs889554851 456 dbSNP
rs114948740 465 dbSNP
rs947739503 466 dbSNP
rs896859853 469 dbSNP
rs559497832 475 dbSNP
rs1189324266 479 dbSNP
rs1371065173 479 dbSNP
rs1438550194 479 dbSNP
rs1361014749 484 dbSNP
rs1214880677 487 dbSNP
rs1279841422 492 dbSNP
rs1333046066 499 dbSNP
rs914903995 506 dbSNP
rs989517335 510 dbSNP
rs1488110200 513 dbSNP
rs935095554 516 dbSNP
rs1469844510 524 dbSNP
rs1242684673 531 dbSNP
rs1214318967 533 dbSNP
rs11555259 537 dbSNP
rs532335062 541 dbSNP
rs940926845 542 dbSNP
rs1463186226 549 dbSNP
rs1188719658 551 dbSNP
rs79011070 570 dbSNP
rs1046572314 579 dbSNP
rs1163698581 584 dbSNP
rs1394619956 587 dbSNP
rs147324082 594 dbSNP
rs746239136 608 dbSNP
rs985342519 609 dbSNP
rs74788225 613 dbSNP
rs1027665476 617 dbSNP
rs1363232360 618 dbSNP
rs1291172538 625 dbSNP
rs774242102 627 dbSNP
rs866664055 634 dbSNP
rs1279900310 639 dbSNP
rs567930322 641 dbSNP
rs2285713 642 dbSNP
rs923950136 650 dbSNP
rs1358572167 651 dbSNP
rs1471078277 653 dbSNP
rs978022831 674 dbSNP
rs184692241 678 dbSNP
rs562604630 679 dbSNP
rs1255874552 681 dbSNP
rs192849379 684 dbSNP
rs557248911 691 dbSNP
rs1418051872 693 dbSNP
rs1420095825 703 dbSNP
rs149653102 704 dbSNP
rs373192958 709 dbSNP
rs1463109064 713 dbSNP
rs1192139143 717 dbSNP
rs954056557 721 dbSNP
rs1401263369 725 dbSNP
rs1026812675 728 dbSNP
rs995265771 745 dbSNP
rs894007133 751 dbSNP
rs1313731606 757 dbSNP
rs559898614 760 dbSNP
rs1342552185 769 dbSNP
rs1053472093 770 dbSNP
rs896869656 772 dbSNP
rs1036718071 777 dbSNP
rs1351466358 778 dbSNP
rs1242988931 781 dbSNP
rs1278730358 784 dbSNP
rs1347625419 795 dbSNP
rs540165639 800 dbSNP
rs189673181 807 dbSNP
rs1258694972 812 dbSNP
rs1443824663 820 dbSNP
rs1253917514 828 dbSNP
rs1179194237 846 dbSNP
rs138261217 853 dbSNP
rs1470167244 857 dbSNP
rs758456542 857 dbSNP
rs752633996 870 dbSNP
rs943914505 874 dbSNP
rs1393135155 880 dbSNP
rs1434015490 884 dbSNP
rs1298301640 888 dbSNP
rs1404048807 896 dbSNP
rs1408481216 899 dbSNP
rs1254355570 905 dbSNP
rs533866174 905 dbSNP
rs1449011788 906 dbSNP
rs895336359 912 dbSNP
rs1053847403 925 dbSNP
rs1235621576 940 dbSNP
rs1258184087 978 dbSNP
rs936759556 987 dbSNP
rs911049604 993 dbSNP
rs1226845785 1004 dbSNP
rs924002634 1006 dbSNP
rs1365195722 1008 dbSNP
rs765296482 1010 dbSNP
rs952663143 1018 dbSNP
rs1250595349 1022 dbSNP
rs919814193 1030 dbSNP
rs1453767627 1035 dbSNP
rs1194161356 1040 dbSNP
rs544603553 1041 dbSNP
rs962341173 1055 dbSNP
rs944064291 1064 dbSNP
rs1302521621 1070 dbSNP
rs1465318829 1083 dbSNP
rs1467374052 1085 dbSNP
rs1015054597 1090 dbSNP
rs1324012794 1093 dbSNP
rs759337897 1123 dbSNP
rs970767340 1126 dbSNP
rs1442307586 1128 dbSNP
rs183616573 1130 dbSNP
rs1325057481 1134 dbSNP
rs879273712 1135 dbSNP
rs1271125691 1138 dbSNP
rs1318242764 1140 dbSNP
rs1200108408 1142 dbSNP
rs1270781592 1143 dbSNP
rs1170326760 1153 dbSNP
rs1012395601 1158 dbSNP
rs564673065 1159 dbSNP
rs1026824018 1162 dbSNP
rs1426648231 1165 dbSNP
rs753697487 1170 dbSNP
rs375705834 1173 dbSNP
rs1054431131 1179 dbSNP
rs1424030571 1183 dbSNP
rs1425067219 1186 dbSNP
rs1478951651 1189 dbSNP
rs961131187 1192 dbSNP
rs1015381694 1193 dbSNP
rs150465548 1198 dbSNP
rs1295820775 1202 dbSNP
rs1180935377 1204 dbSNP
rs1481127716 1206 dbSNP
rs1382156545 1211 dbSNP
rs1277209665 1213 dbSNP
rs902176635 1220 dbSNP
rs1342749430 1221 dbSNP
rs867634622 1222 dbSNP
rs1012919772 1230 dbSNP
rs1244956736 1231 dbSNP
rs1293192920 1239 dbSNP
rs895362025 1241 dbSNP
rs199613345 1247 dbSNP
rs1263655852 1250 dbSNP
rs28649856 1253 dbSNP
rs866805626 1258 dbSNP
rs567107060 1279 dbSNP
rs1312209317 1285 dbSNP
rs1417353058 1288 dbSNP
rs1424605991 1290 dbSNP
rs910934674 1296 dbSNP
rs766143500 1297 dbSNP
rs149844031 1299 dbSNP
rs1453738320 1306 dbSNP
rs546468294 1316 dbSNP
rs781099321 1317 dbSNP
rs1042491591 1320 dbSNP
rs760368072 1321 dbSNP
rs191465352 1325 dbSNP
rs1396219338 1336 dbSNP
rs772777312 1351 dbSNP
rs931112186 1358 dbSNP
rs912563583 1359 dbSNP
rs985441183 1380 dbSNP
rs1286562434 1382 dbSNP
rs919883593 1383 dbSNP
rs77141582 1392 dbSNP
rs567967073 1393 dbSNP
rs1483726028 1394 dbSNP
rs1183796613 1399 dbSNP
rs771584969 1406 dbSNP
rs1418537614 1410 dbSNP
rs1015432675 1425 dbSNP
rs1186311632 1437 dbSNP
rs761348437 1439 dbSNP
rs1419293459 1448 dbSNP
rs907883390 1451 dbSNP
rs187860533 1455 dbSNP
rs1466248483 1476 dbSNP
rs1485593045 1479 dbSNP
rs183502177 1482 dbSNP
rs775913208 1490 dbSNP
rs531382827 1492 dbSNP
rs1390250451 1497 dbSNP
rs971136933 1504 dbSNP
rs1379118004 1506 dbSNP
rs1231956440 1511 dbSNP
rs1279405535 1512 dbSNP
rs1312507753 1518 dbSNP
rs557604677 1526 dbSNP
rs1212552036 1528 dbSNP
rs568751068 1530 dbSNP
rs1480357473 1535 dbSNP
rs1482951479 1545 dbSNP
rs552282510 1552 dbSNP
rs895412841 1557 dbSNP
rs991030114 1567 dbSNP
rs1453168903 1573 dbSNP
rs958428061 1581 dbSNP
rs1032584223 1582 dbSNP
rs373688542 1586 dbSNP
rs1177803702 1587 dbSNP
rs1352463117 1589 dbSNP
rs1264923584 1593 dbSNP
rs1331493556 1596 dbSNP
rs1401820386 1599 dbSNP
rs1032636201 1601 dbSNP
rs1000179770 1602 dbSNP
rs902741259 1606 dbSNP
rs1019244821 1610 dbSNP
rs1220683879 1615 dbSNP
rs1293170634 1616 dbSNP
rs192093469 1618 dbSNP
rs1199482127 1626 dbSNP
rs1260100406 1627 dbSNP
rs1042528004 1628 dbSNP
rs1407709676 1629 dbSNP
rs889546306 1632 dbSNP
rs1049457295 1634 dbSNP
rs559788871 1635 dbSNP
rs757375174 1636 dbSNP
rs1278371023 1637 dbSNP
rs1477321712 1639 dbSNP
rs1170893066 1644 dbSNP
rs1425190936 1648 dbSNP
rs898313672 1650 dbSNP
rs1036830352 1651 dbSNP
rs1388567777 1654 dbSNP
rs939933168 1657 dbSNP
rs1438482327 1662 dbSNP
rs928510602 1670 dbSNP
rs1050204077 1672 dbSNP
rs781618249 1673 dbSNP
rs1280257174 1676 dbSNP
rs919908512 1679 dbSNP
rs1232809259 1680 dbSNP
rs1038335580 1684 dbSNP
rs1413663078 1687 dbSNP
rs1453878762 1691 dbSNP
rs1214253201 1692 dbSNP
rs565063581 1701 dbSNP
rs751766422 1708 dbSNP
rs1156535598 1717 dbSNP
rs1472436683 1719 dbSNP
rs529798285 1720 dbSNP
rs188519742 1722 dbSNP
rs1413856744 1723 dbSNP
rs577804544 1724 dbSNP
rs971572458 1729 dbSNP
rs540508236 1731 dbSNP
rs1032932750 1732 dbSNP
rs183525566 1740 dbSNP
rs1353870495 1741 dbSNP
rs991632135 1747 dbSNP
rs1466323908 1756 dbSNP
rs966952100 1761 dbSNP
rs1266403986 1767 dbSNP
rs1285852281 1769 dbSNP
rs957056493 1770 dbSNP
rs1019797868 1771 dbSNP
rs1278629508 1786 dbSNP
rs1484513293 1789 dbSNP
rs1186338319 1792 dbSNP
rs575638346 1793 dbSNP
rs1473453718 1803 dbSNP
rs1228018224 1820 dbSNP
rs747232386 1824 dbSNP
rs1175420619 1828 dbSNP
rs889433251 1839 dbSNP
rs1275208079 1846 dbSNP
rs1160282400 1858 dbSNP
rs568000690 1858 dbSNP
rs1373372829 1859 dbSNP
rs1001082008 1868 dbSNP
rs113235454 1868 dbSNP
rs1329248576 1874 dbSNP
rs1021561354 1895 dbSNP
rs76268496 1901 dbSNP
rs995671086 1903 dbSNP
rs1308612801 1904 dbSNP
rs1435130861 1916 dbSNP
rs113898153 1920 dbSNP
rs1318045584 1921 dbSNP
rs1037288716 1922 dbSNP
rs996932615 1926 dbSNP
rs1344703619 1929 dbSNP
rs1199529285 1930 dbSNP
rs758463126 1930 dbSNP
rs1443771114 1935 dbSNP
rs1196281926 1949 dbSNP
rs1038343996 1957 dbSNP
rs907147096 1959 dbSNP
rs1180383497 1960 dbSNP
rs1045658362 1967 dbSNP
rs949403587 1975 dbSNP
rs545514089 1979 dbSNP
rs191231524 1980 dbSNP
rs553461152 1991 dbSNP
rs186376950 1996 dbSNP
rs758619890 1997 dbSNP
rs536838336 2004 dbSNP
rs1301794453 2010 dbSNP
rs1330898337 2010 dbSNP
rs977035217 2014 dbSNP
rs1246257357 2021 dbSNP
rs574278793 2028 dbSNP
rs1208255035 2029 dbSNP
rs1346730495 2038 dbSNP
rs987012328 2046 dbSNP
rs954260650 2048 dbSNP
rs1216390457 2049 dbSNP
rs1461926467 2052 dbSNP
rs1256899294 2055 dbSNP
rs1457792233 2058 dbSNP
rs1028407689 2059 dbSNP
rs1021236587 2060 dbSNP
rs966948826 2060 dbSNP
rs1199392943 2063 dbSNP
rs1281049055 2067 dbSNP
rs1201927056 2071 dbSNP
rs995158252 2080 dbSNP
rs962787803 2084 dbSNP
rs1170188643 2093 dbSNP
rs1008877566 2094 dbSNP
rs1467197330 2095 dbSNP
rs754951024 2099 dbSNP
rs955606958 2101 dbSNP
rs1390725725 2102 dbSNP
rs369483334 2106 dbSNP
rs376426988 2108 dbSNP
rs1274117917 2111 dbSNP
rs1015330240 2125 dbSNP
rs1028903625 2127 dbSNP
rs1004072148 2131 dbSNP
rs907032249 2132 dbSNP
rs568862940 2136 dbSNP
rs1220001317 2137 dbSNP
rs551907433 2137 dbSNP
rs1016964351 2141 dbSNP
rs1210339923 2146 dbSNP
rs1294736288 2156 dbSNP
rs1269235692 2160 dbSNP
rs538212491 2170 dbSNP
rs887093081 2172 dbSNP
rs1359337689 2177 dbSNP
rs1264243024 2186 dbSNP
rs371717619 2192 dbSNP
rs1045670820 2193 dbSNP
rs950004405 2202 dbSNP
rs1367940789 2204 dbSNP
rs148330651 2209 dbSNP
rs894319023 2216 dbSNP
rs546243242 2220 dbSNP
rs1055515570 2223 dbSNP
rs1299174392 2231 dbSNP
rs1401947094 2235 dbSNP
rs529887233 2237 dbSNP
rs1340817644 2241 dbSNP
rs560742490 2242 dbSNP
rs71603039 2243 dbSNP
rs1055553558 2253 dbSNP
rs1401430828 2256 dbSNP
rs936657440 2265 dbSNP
rs1310021806 2266 dbSNP
rs935773586 2270 dbSNP
rs1245433500 2272 dbSNP
rs1169695434 2275 dbSNP
rs114868214 2289 dbSNP
rs765654087 2292 dbSNP
rs755907451 2293 dbSNP
rs945590345 2305 dbSNP
rs912724651 2306 dbSNP
rs1489420526 2309 dbSNP
rs911546394 2323 dbSNP
rs1255599499 2343 dbSNP
rs1424406602 2344 dbSNP
rs1432561049 2345 dbSNP
rs987106230 2350 dbSNP
rs955778217 2357 dbSNP
rs1419623054 2361 dbSNP
rs750040148 2362 dbSNP
rs530696915 2363 dbSNP
rs1362824680 2364 dbSNP
rs1455046144 2368 dbSNP
rs1300644975 2369 dbSNP
rs1400888086 2370 dbSNP
rs1239382693 2375 dbSNP
rs975555406 2376 dbSNP
rs1314245254 2379 dbSNP
rs1185708054 2380 dbSNP
rs1440415214 2383 dbSNP
rs1374620070 2388 dbSNP
rs1309738557 2390 dbSNP
rs768513646 2390 dbSNP
rs962799991 2391 dbSNP
rs1326821003 2396 dbSNP
rs1317142522 2401 dbSNP
rs1208291463 2403 dbSNP
rs986889360 2404 dbSNP
rs759917510 2409 dbSNP
rs182161855 2413 dbSNP
rs1344184230 2419 dbSNP
rs921495465 2423 dbSNP
rs1179761545 2428 dbSNP
rs1439674599 2428 dbSNP
rs1004279771 2430 dbSNP
rs974171977 2434 dbSNP
rs887152730 2436 dbSNP
rs767085038 2439 dbSNP
rs1024717967 2441 dbSNP
rs545079196 2442 dbSNP
rs1226965777 2448 dbSNP
rs1397434420 2453 dbSNP
rs1445990591 2455 dbSNP
rs962387253 2456 dbSNP
rs1379276558 2461 dbSNP
rs1331879655 2474 dbSNP
rs1378859256 2479 dbSNP
rs1217325368 2484 dbSNP
rs1300333076 2501 dbSNP
rs1313040171 2504 dbSNP
rs1015798436 2505 dbSNP
rs573226390 2528 dbSNP
rs1445346336 2537 dbSNP
rs894361888 2538 dbSNP
rs1199835147 2540 dbSNP
rs1240634621 2548 dbSNP
rs1380133737 2555 dbSNP
rs1487788807 2563 dbSNP
rs935867410 2569 dbSNP
rs1426282862 2580 dbSNP
rs1308996355 2594 dbSNP
rs971103101 2605 dbSNP
rs904348040 2616 dbSNP
rs1041487107 2631 dbSNP
rs945780187 2635 dbSNP
rs1170759644 2637 dbSNP
rs911569969 2639 dbSNP
rs559932041 2649 dbSNP
rs761258943 2662 dbSNP
rs1292781050 2664 dbSNP
rs934277601 2668 dbSNP
rs1407031491 2689 dbSNP
rs1276472230 2692 dbSNP
rs1317503165 2694 dbSNP
rs1219396167 2696 dbSNP
rs189889713 2698 dbSNP
rs1221410934 2699 dbSNP
rs773840933 2714 dbSNP
rs763664336 2722 dbSNP
rs1489631455 2725 dbSNP
rs1405968223 2746 dbSNP
rs975648700 2753 dbSNP
rs777237315 2755 dbSNP
rs760007575 2760 dbSNP
rs962893168 2765 dbSNP
rs1416058945 2774 dbSNP
rs1477288997 2778 dbSNP
rs574317447 2780 dbSNP
rs557251455 2781 dbSNP
rs903852737 2783 dbSNP
rs1403561034 2794 dbSNP
rs1163943254 2795 dbSNP
rs1017109152 2823 dbSNP
rs1426377439 2835 dbSNP
rs1472585545 2842 dbSNP
rs1252859887 2845 dbSNP
rs1296108334 2851 dbSNP
rs114559592 2861 dbSNP
rs951508201 2862 dbSNP
rs1024329078 2870 dbSNP
rs573570072 2882 dbSNP
rs945464546 2895 dbSNP
rs1228254698 2897 dbSNP
rs1014644091 2900 dbSNP
rs1324017452 2918 dbSNP
rs1214992607 2920 dbSNP
rs1483926058 2922 dbSNP
rs958722420 2931 dbSNP
rs1034253818 2938 dbSNP
rs1000067548 2945 dbSNP
rs904400441 2948 dbSNP
rs1180755495 2949 dbSNP
rs1041498671 2964 dbSNP
rs1156661013 2967 dbSNP
rs912621687 2967 dbSNP
rs1009990224 2971 dbSNP
rs1420572022 2975 dbSNP
rs1320457137 2982 dbSNP
rs1051215719 2987 dbSNP
rs890177567 2988 dbSNP
rs932805970 2992 dbSNP
rs1291382221 2997 dbSNP
rs1226164502 3001 dbSNP
rs1385674918 3004 dbSNP
rs1238583618 3005 dbSNP
rs555595478 3013 dbSNP
rs1354819720 3027 dbSNP
rs1205363609 3047 dbSNP
rs1285849183 3065 dbSNP
rs1440330714 3074 dbSNP
rs1288626591 3080 dbSNP
rs1412016153 3083 dbSNP
rs747365673 3084 dbSNP
rs773417210 3090 dbSNP
rs941056788 3094 dbSNP
rs1437803531 3097 dbSNP
rs1379457433 3102 dbSNP
rs1440013250 3115 dbSNP
rs941584212 3122 dbSNP
rs908209357 3124 dbSNP
rs982406575 3136 dbSNP
rs983332707 3137 dbSNP
rs971155444 3143 dbSNP
rs1331189269 3146 dbSNP
rs1378131464 3152 dbSNP
rs1241705924 3153 dbSNP
rs917352341 3156 dbSNP
rs1024033026 3158 dbSNP
rs992910571 3165 dbSNP
rs958738890 3170 dbSNP
rs1462214817 3174 dbSNP
rs1196686217 3182 dbSNP
rs1161666519 3187 dbSNP
rs1237552967 3190 dbSNP
rs1438322804 3198 dbSNP
rs1473409816 3201 dbSNP
rs578200046 3203 dbSNP
rs78982143 3204 dbSNP
rs1176461557 3226 dbSNP
rs1173339627 3232 dbSNP
rs1464080183 3238 dbSNP
rs1170045870 3240 dbSNP
rs1488752590 3241 dbSNP
rs1248426135 3242 dbSNP
rs1218694111 3249 dbSNP
rs1322007322 3262 dbSNP
rs968568384 3266 dbSNP
rs1268311493 3278 dbSNP
rs1229860277 3280 dbSNP
rs958551086 3281 dbSNP
rs1173696985 3282 dbSNP
rs1216326321 3283 dbSNP
rs1433629292 3286 dbSNP
rs1288101450 3288 dbSNP
rs1220227839 3289 dbSNP
rs1340048172 3290 dbSNP
rs1394933560 3293 dbSNP
rs1370307582 3297 dbSNP
rs1273602041 3298 dbSNP
rs868455504 3299 dbSNP
rs1168801820 3300 dbSNP
rs1450760918 3301 dbSNP
rs1476566099 3301 dbSNP
rs371719738 3301 dbSNP
rs1389473624 3302 dbSNP
rs1200436269 3310 dbSNP
rs1271396566 3317 dbSNP
rs1322717460 3317 dbSNP
rs1455827616 3318 dbSNP
rs1476944626 3320 dbSNP
rs1388238770 3322 dbSNP
rs1158061386 3323 dbSNP
rs112944920 3324 dbSNP
rs1161906156 3324 dbSNP
rs1229529626 3324 dbSNP
rs1263549372 3324 dbSNP
rs1277045474 3324 dbSNP
rs1305333193 3324 dbSNP
rs1326463746 3324 dbSNP
rs1347053864 3324 dbSNP
rs1390482536 3324 dbSNP
rs1397727029 3324 dbSNP
rs1406374276 3324 dbSNP
rs1424360188 3324 dbSNP
rs1464003986 3324 dbSNP
rs1491213924 3324 dbSNP
rs67674001 3324 dbSNP
rs763021712 3324 dbSNP
rs1243086418 3325 dbSNP
rs1368460504 3325 dbSNP
rs1430321311 3325 dbSNP
rs1491531814 3325 dbSNP
rs1165918699 3326 dbSNP
rs1358972351 3326 dbSNP
rs201856994 3326 dbSNP
rs1297130658 3327 dbSNP
rs1417517355 3327 dbSNP
rs1433591576 3329 dbSNP
rs1385073535 3338 dbSNP
rs7674356 3338 dbSNP
rs1339851042 3344 dbSNP
rs1427123917 3360 dbSNP
rs890281428 3364 dbSNP
rs1239711232 3366 dbSNP
rs375329085 3367 dbSNP
rs1261592484 3382 dbSNP
rs1486968617 3387 dbSNP
rs1051974049 3396 dbSNP
rs1255533971 3409 dbSNP
rs144936228 3410 dbSNP
rs116121278 3426 dbSNP
rs1439413550 3430 dbSNP
rs1248102952 3448 dbSNP
rs145544781 3454 dbSNP
rs535928618 3459 dbSNP
rs755145366 3461 dbSNP
rs186182329 3463 dbSNP
rs13120790 3464 dbSNP
rs891237593 3465 dbSNP
rs13120788 3466 dbSNP
rs1300590000 3467 dbSNP
rs910108520 3468 dbSNP
rs1453288202 3481 dbSNP
rs117518506 3482 dbSNP
rs1314321131 3498 dbSNP
rs932852145 3512 dbSNP
rs917421847 3513 dbSNP
rs993356701 3514 dbSNP
rs958750238 3517 dbSNP
rs1231275987 3521 dbSNP
rs1299735350 3534 dbSNP
rs28547481 3536 dbSNP
rs1457709411 3545 dbSNP
rs755895199 3552 dbSNP
rs565033656 3554 dbSNP
rs1253037891 3563 dbSNP
rs1420532622 3567 dbSNP
rs1173430027 3568 dbSNP
rs1299889910 3569 dbSNP
rs141228065 3573 dbSNP
rs767405690 3587 dbSNP
rs1303668726 3591 dbSNP
rs1398072627 3593 dbSNP
rs779827432 3594 dbSNP
rs1020649026 3596 dbSNP
rs982457512 3601 dbSNP
rs528533500 3603 dbSNP
rs917028454 3606 dbSNP
rs1385314300 3609 dbSNP
rs1300780019 3613 dbSNP
rs1346377219 3618 dbSNP
rs1030155208 3620 dbSNP
rs1434015759 3625 dbSNP
rs1256205258 3626 dbSNP
rs991236628 3636 dbSNP
rs756901468 3639 dbSNP
rs900212944 3642 dbSNP
rs1253450724 3644 dbSNP
rs559766797 3664 dbSNP
rs978976796 3665 dbSNP
rs543169672 3666 dbSNP
rs1005921206 3668 dbSNP
rs1267817396 3677 dbSNP
rs886089689 3678 dbSNP
rs1201018414 3681 dbSNP
rs117204630 3683 dbSNP
rs1409336420 3684 dbSNP
rs1170979454 3686 dbSNP
rs563767451 3691 dbSNP
rs895980505 3692 dbSNP
rs1346437144 3694 dbSNP
rs1276416106 3700 dbSNP
rs1009544317 3701 dbSNP
rs1278032291 3708 dbSNP
rs891123204 3711 dbSNP
rs1029736001 3712 dbSNP
rs1221345379 3720 dbSNP
rs1292932141 3724 dbSNP
rs937446421 3725 dbSNP
rs1224203259 3732 dbSNP
rs1260415513 3741 dbSNP
rs927351792 3749 dbSNP
rs978801377 3751 dbSNP
rs543665389 3755 dbSNP
rs899874948 3757 dbSNP
rs1426788860 3761 dbSNP
rs1296513142 3765 dbSNP
rs1344814565 3766 dbSNP
rs1038553018 3767 dbSNP
rs1431655527 3768 dbSNP
rs1290674430 3780 dbSNP
rs1341562794 3783 dbSNP
rs954614341 3786 dbSNP
rs941498258 3787 dbSNP
rs887386643 3794 dbSNP
rs974548878 3804 dbSNP
rs762473205 3824 dbSNP
rs182000275 3829 dbSNP
rs117783182 3847 dbSNP
rs1005974166 3856 dbSNP
rs1385643981 3859 dbSNP
rs949741018 3860 dbSNP
rs886138966 3868 dbSNP
rs192021480 3872 dbSNP
rs994830775 3873 dbSNP
rs1055836333 3877 dbSNP
rs1427187287 3889 dbSNP
rs896047717 3900 dbSNP
rs1385604435 3911 dbSNP
rs1452554571 3911 dbSNP
rs769664483 3911 dbSNP
rs3087494 3912 dbSNP
rs925663560 3913 dbSNP
rs1425164114 3928 dbSNP
rs1253688272 3929 dbSNP
rs1349571284 3931 dbSNP
rs978645046 3933 dbSNP
rs967162529 3940 dbSNP
rs906022156 3943 dbSNP
rs1187629027 3945 dbSNP
rs1483600298 3946 dbSNP
rs1254523831 3966 dbSNP
rs913188015 3971 dbSNP
rs1462570457 3990 dbSNP
rs1176594622 3992 dbSNP
rs987341403 3995 dbSNP
rs947464183 3998 dbSNP
rs372498036 3999 dbSNP
rs1266101305 4001 dbSNP
rs913229590 4003 dbSNP
rs1247148632 4007 dbSNP
rs1029619986 4012 dbSNP
rs1464503790 4019 dbSNP
rs997230096 4019 dbSNP
rs964176131 4024 dbSNP
rs1336690530 4026 dbSNP
rs1292944054 4031 dbSNP
rs933249860 4034 dbSNP
rs1232389147 4035 dbSNP
rs569314732 4037 dbSNP
rs1017420440 4038 dbSNP
rs1005743588 4047 dbSNP
rs887272511 4048 dbSNP
rs1272027229 4049 dbSNP
rs1183705950 4052 dbSNP
rs781162389 4057 dbSNP
rs1267122707 4064 dbSNP
rs1480215696 4066 dbSNP
rs28377596 4075 dbSNP
rs964581823 4081 dbSNP
rs1464552526 4085 dbSNP
rs1293571568 4089 dbSNP
rs1397815130 4095 dbSNP
rs1459021040 4106 dbSNP
rs909041232 4109 dbSNP
rs1321950325 4127 dbSNP
rs1163781913 4128 dbSNP
rs1283402190 4136 dbSNP
rs1346776874 4144 dbSNP
rs1014524126 4148 dbSNP
rs1269584150 4159 dbSNP
rs1473085897 4168 dbSNP
rs896033909 4170 dbSNP
rs535819874 4171 dbSNP
rs1289298243 4172 dbSNP
rs1180545219 4177 dbSNP
rs772630672 4178 dbSNP
rs1223455964 4179 dbSNP
rs7692543 4184 dbSNP
rs556967130 4187 dbSNP
rs1192551572 4194 dbSNP
rs748345490 4206 dbSNP
rs1043193173 4215 dbSNP
rs1476660712 4229 dbSNP
rs1161850036 4230 dbSNP
rs1384956852 4236 dbSNP
rs536893969 4238 dbSNP
rs571409156 4248 dbSNP
rs148909770 4250 dbSNP
rs913075049 4255 dbSNP
rs1380095928 4261 dbSNP
rs960637273 4272 dbSNP
rs1327006839 4275 dbSNP
rs1035926290 4277 dbSNP
rs528372273 4280 dbSNP
rs987225100 4294 dbSNP
rs954644270 4305 dbSNP
rs921816123 4308 dbSNP
rs1247013007 4312 dbSNP
rs1294301906 4315 dbSNP
rs975468840 4317 dbSNP
rs774759271 4323 dbSNP
rs1484996043 4325 dbSNP
rs1204676629 4326 dbSNP
rs906074713 4340 dbSNP
rs964372835 4342 dbSNP
rs1043170373 4343 dbSNP
rs1017058813 4346 dbSNP
rs1006043661 4347 dbSNP
rs145556451 4353 dbSNP
rs757324033 4354 dbSNP
rs1053541843 4362 dbSNP
rs768805159 4363 dbSNP
rs1184068487 4372 dbSNP
rs554542241 4372 dbSNP
rs896097675 4380 dbSNP
rs1385004104 4383 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000243501.5 | 3UTR | GGAAGCAGAGGUUGCAGUGAGCUGAGAUUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000243501.5 | 3UTR | GGAAGCAGAGGUUGCAGUGAGCUGAGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000243501.5 | 3UTR | GGUUGAACCUGGGAAGCAGAGGUUGCAGUGAGCUGAGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.618 8.2e-5 0.519 1.2e-3 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.573 1.7e-3 0.589 1.2e-3 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.549 3.3e-3 0.560 2.7e-3 23 Click to see details
GSE28260 Renal cortex and medulla -0.634 1.0e-2 -0.578 1.9e-2 13 Click to see details
GSE38226 Liver fibrosis 0.404 3.5e-2 0.415 3.1e-2 21 Click to see details
GSE19350 CNS germ cell tumors -0.475 5.9e-2 0.009 4.9e-1 12 Click to see details
GSE28544 Breast cancer -0.289 8.5e-2 -0.489 7.7e-3 24 Click to see details
GSE14794 Lymphoblastoid cells -0.107 1.6e-1 -0.033 3.8e-1 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.216 1.8e-1 -0.624 1.6e-3 20 Click to see details
GSE21849 B cell lymphoma 0.163 2.0e-1 0.481 4.1e-3 29 Click to see details
GSE17306 Multiple myeloma -0.091 2.7e-1 0.361 5.4e-3 49 Click to see details
GSE27834 Pluripotent stem cells -0.133 3.1e-1 -0.288 1.4e-1 16 Click to see details
GSE21687 Ependynoma primary tumors -0.06 3.2e-1 -0.209 4.9e-2 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.06 3.9e-1 0.094 3.3e-1 25 Click to see details
GSE17498 Multiple myeloma 0.033 4.2e-1 0.034 4.2e-1 40 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.023 4.6e-1 0.504 5.1e-3 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PAAD 0.903 0.05 0.800 0.1 4 Click to see details
THCA 0.15 0.16 0.134 0.18 47 Click to see details
PRAD -0.17 0.18 -0.142 0.22 31 Click to see details
STAD 0.215 0.18 0.203 0.2 20 Click to see details
KIRC 0.13 0.25 0.192 0.16 29 Click to see details
KIRP -0.167 0.25 0.104 0.34 18 Click to see details
UCEC 0.235 0.26 0.164 0.33 10 Click to see details
HNSC -0.139 0.26 -0.249 0.13 23 Click to see details
BRCA 0.082 0.35 0.049 0.41 25 Click to see details
LUSC -0.082 0.37 -0.138 0.28 20 Click to see details
ESCA 0.232 0.38 0.400 0.3 4 Click to see details
BLCA 0.077 0.42 -0.055 0.44 10 Click to see details
KICH 0.046 0.45 0.064 0.43 11 Click to see details
LUAD -0.036 0.46 -0.017 0.48 9 Click to see details
LIHC -0.011 0.47 -0.009 0.48 45 Click to see details
CHOL -0.004 0.5 -0.167 0.35 8 Click to see details
CHOL -0.004 0.5 -0.167 0.35 8 Click to see details
CHOL -0.004 0.5 -0.167 0.35 8 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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