pre-miRNA Information
pre-miRNA hsa-mir-640   
Genomic Coordinates chr19: 19435063 - 19435158
Synonyms MIRN640, hsa-mir-640, MIR640
Description Homo sapiens miR-640 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-640
Sequence 61| AUGAUCCAGGAACCUGCCUCU |81
Evidence Experimental
Experiments RT-PCR
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30153378 1 COSMIC
COSN23015356 12 COSMIC
COSN30513185 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs111726405 1 dbSNP
rs765622881 2 dbSNP
rs1249744889 6 dbSNP
rs752995186 12 dbSNP
rs758746736 13 dbSNP
rs918887970 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TTC31   
Synonyms -
Description tetratricopeptide repeat domain 31
Transcript NM_022492   
Expression
Putative miRNA Targets on TTC31
3'UTR of TTC31
(miRNA target sites are highlighted)
>TTC31|NM_022492|3'UTR
   1 GGGGGCACCGGTCCCTCATAGGGCAGGGCCATGTATATATCCCTTGGTGGGGGACATAGTGTGGTGACAGTTCACTGCAT
  81 ATTTTGAGACCTTATTCTCTAGATCCATAGTTAATGATGCCCTGGCAGTCATTCCTCTTGCCATGGGGAAGCTTCTGATG
 161 AGAGAAAGGAGCCCCACATCCACTGAAACATCCTTTGGTTCTCAAGCTTCTTCTGGAGGCAGTAAGGAAAAATAAAACCC
 241 ACCAAGGCTCAAGAAGGGAACTATAGAAAAGTTCAGGTTTTTAGGCTATAGCAGAGACAGTGAGAAAGCATCTGGGCCTT
 321 TCTCTTCCTCTTGGTCCAGGGGACCTCATTCACCAACTAGAGCTTGGTGTACAGGAACGGGGTCACAGTGCTGAGGGGGC
 401 TTGAGTCCCACCTTTCAGCTTGATGGATGCTCACCTCTTCTCAGCCCCAGCTCGTGCCCTGTTTTTCTAGCCATAGCCCC
 481 CAGATTACTCACAGCTCCTCATGCCATTTCCTGTCCAGATTGCTATGTATGACTCTGACCTCTCTTGTCCAGTGGTCTGG
 561 TGCTCACCTCCTCTCACTGCTAGAATATTCACCAAGGGTTTGCATTTGGGAAGTCCCTTACCAGCTCCTGCTTAGAGCTG
 641 GTAGGGCCATACATGTCCACACTCCCAACTGGTGGCTCTCCCGCTGAATGGGGCCTCAGCAGGTGCCCAAGCTGCTACAA
 721 CCTTGGCCACTCTGTTTCTCCACCCCAGCACTGGGCATGGTAATTAGCCTTTCCCCATGTTAATTTATTCAGTTTTTTCA
 801 AGGGTCAACTGAATTCCCCACTTCCTGGGTAAGAAGCATGATCTCCTTTTAATTTCACGTCTAAGATCCTGGCAGCTTCC
 881 CCTAGCTGGTTCCTCTGTAGTCCTGCTGGGACTGTCAGCTCATTTAAATGTGGGTCTGCAGAAGGCTTTAGGTCTCCCCC
 961 AACCCCCTTACCTTTCACAGAGGAACCTTTCATCAGGATAAATGATTATTGCTGCCCTGTGGGTCTTGCTCAATACTGTT
1041 CATACCTGGAGAGAGAAGGTATTGAAACATCTCCTTTATGTGTGACTTTCCCAAATTTTTAAAAATTGTTTATGGTTTAG
1121 GCCCCTTAAATACTGTGTAGCAGGATGAAGTCTACCATTACCAGCTGGGTCACCTTGGATGGGTCTGTCAACATCTAAGC
1201 CTCAGTTCCCTCACCTGTAAAAATGAGGGTAGTCCCTACCTCATAAGGGATATTGTGAGGATGGAAAGCGAAAGTGTGAG
1281 AAAATACCTCCCAAGTGCCTGGTACATAGTGGGTGCTAAATAAACCACTTTTTGTCTGCAACTGTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucuccGUCCAAGGACCUAGUa 5'
               |||    ||||:||| 
Target 5' attacCAG----CTGGGTCAc 3'
1157 - 1173 130.00 -11.30
2
miRNA  3' ucuccGUCCAAGGACCUAgua 5'
               ||| ||  |||||   
Target 5' cctttCAGCTTGATGGATgct 3'
411 - 431 116.00 -7.22
3
miRNA  3' ucuCCGUCCAAG------GACCUAGua 5'
             ||||| |||      |||| ||  
Target 5' cctGGCAGCTTCCCCTAGCTGGTTCct 3'
868 - 894 112.00 -13.54
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8581260 5 COSMIC
COSM2999691 11 COSMIC
COSM7830195 23 COSMIC
COSM9371825 44 COSMIC
COSM8585250 54 COSMIC
COSM9034720 57 COSMIC
COSN28968534 273 COSMIC
COSN31959777 505 COSMIC
COSN5956353 1009 COSMIC
COSN15880804 1237 COSMIC
rs2301984 711 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs920929678 1 dbSNP
rs752345943 2 dbSNP
rs936377039 3 dbSNP
rs1488106041 4 dbSNP
rs777554773 6 dbSNP
rs1267872105 9 dbSNP
rs746771022 10 dbSNP
rs770812364 11 dbSNP
rs1181026372 12 dbSNP
rs1412247711 15 dbSNP
rs745839013 16 dbSNP
rs1010382010 18 dbSNP
rs369642494 20 dbSNP
rs545843734 22 dbSNP
rs772179494 23 dbSNP
rs1281708581 24 dbSNP
rs1349027414 26 dbSNP
rs374075589 29 dbSNP
rs780084639 33 dbSNP
rs992565345 33 dbSNP
rs1288763078 34 dbSNP
rs1289296860 34 dbSNP
rs377564677 36 dbSNP
rs766806399 38 dbSNP
rs754258292 41 dbSNP
rs760139787 42 dbSNP
rs1222224849 43 dbSNP
rs1267083084 50 dbSNP
rs1481989037 56 dbSNP
rs1204138581 60 dbSNP
rs1252151213 61 dbSNP
rs1473380495 62 dbSNP
rs764779579 69 dbSNP
rs752256076 74 dbSNP
rs747262963 78 dbSNP
rs1167594544 80 dbSNP
rs1369244384 82 dbSNP
rs1429562948 87 dbSNP
rs564514408 88 dbSNP
rs528529827 91 dbSNP
rs777272962 92 dbSNP
rs1274435949 96 dbSNP
rs1262392198 104 dbSNP
rs951563224 109 dbSNP
rs1446132702 115 dbSNP
rs1044316874 119 dbSNP
rs1349552979 121 dbSNP
rs755943519 126 dbSNP
rs982606398 130 dbSNP
rs1332563368 135 dbSNP
rs1261489042 136 dbSNP
rs1019851598 138 dbSNP
rs1308419522 138 dbSNP
rs1295533362 142 dbSNP
rs1380988256 162 dbSNP
rs1359265221 177 dbSNP
rs1338062569 184 dbSNP
rs1452713969 194 dbSNP
rs547160929 219 dbSNP
rs1334251985 228 dbSNP
rs935940121 240 dbSNP
rs115795272 243 dbSNP
rs1169661371 246 dbSNP
rs891818452 248 dbSNP
rs552130610 251 dbSNP
rs1265439161 264 dbSNP
rs921190007 275 dbSNP
rs796575468 282 dbSNP
rs934043471 283 dbSNP
rs1460900346 289 dbSNP
rs762375884 291 dbSNP
rs1426029559 293 dbSNP
rs1200700935 295 dbSNP
rs1165952643 297 dbSNP
rs551271547 303 dbSNP
rs1251048916 304 dbSNP
rs913626613 318 dbSNP
rs1324090433 321 dbSNP
rs1452610600 329 dbSNP
rs1156526924 332 dbSNP
rs1246129380 334 dbSNP
rs1381373988 338 dbSNP
rs1007433106 344 dbSNP
rs1017112595 346 dbSNP
rs1297449532 349 dbSNP
rs1396962942 349 dbSNP
rs945107475 355 dbSNP
rs898715785 358 dbSNP
rs994397853 367 dbSNP
rs1164104306 369 dbSNP
rs139717044 371 dbSNP
rs1056023302 372 dbSNP
rs758444530 379 dbSNP
rs995481893 380 dbSNP
rs193041611 382 dbSNP
rs1026999344 384 dbSNP
rs558740785 399 dbSNP
rs1293204821 403 dbSNP
rs1024514294 412 dbSNP
rs144023606 413 dbSNP
rs114206720 415 dbSNP
rs1240542880 419 dbSNP
rs925820949 423 dbSNP
rs1288481634 438 dbSNP
rs1305807637 439 dbSNP
rs533643010 450 dbSNP
rs975220966 452 dbSNP
rs757823607 454 dbSNP
rs538104273 455 dbSNP
rs1363808883 459 dbSNP
rs555079760 462 dbSNP
rs1454372934 474 dbSNP
rs1363481326 477 dbSNP
rs1179900490 480 dbSNP
rs1481636437 487 dbSNP
rs573480477 489 dbSNP
rs1484532679 490 dbSNP
rs556520506 501 dbSNP
rs1490018926 502 dbSNP
rs934022183 506 dbSNP
rs146447624 507 dbSNP
rs76475865 514 dbSNP
rs80255504 515 dbSNP
rs1182883383 521 dbSNP
rs1259802983 526 dbSNP
rs889836116 527 dbSNP
rs942813519 531 dbSNP
rs989385924 533 dbSNP
rs913540555 539 dbSNP
rs1404098379 541 dbSNP
rs1343638381 543 dbSNP
rs1320172585 552 dbSNP
rs945102015 555 dbSNP
rs1384283382 557 dbSNP
rs1157079419 559 dbSNP
rs1471044681 560 dbSNP
rs1430228244 561 dbSNP
rs555956580 564 dbSNP
rs774214119 582 dbSNP
rs1244378957 591 dbSNP
rs1194455212 598 dbSNP
rs898688290 600 dbSNP
rs1260348173 626 dbSNP
rs1206457465 637 dbSNP
rs1325320717 638 dbSNP
rs994366569 646 dbSNP
rs1025886709 648 dbSNP
rs1172504111 649 dbSNP
rs886103592 652 dbSNP
rs1342587255 653 dbSNP
rs1055989572 658 dbSNP
rs1303428442 670 dbSNP
rs1013836025 672 dbSNP
rs775229406 683 dbSNP
rs368996048 684 dbSNP
rs1048698282 696 dbSNP
rs1287255195 701 dbSNP
rs577821228 704 dbSNP
rs573024482 706 dbSNP
rs2301984 711 dbSNP
rs1422039092 712 dbSNP
rs542242755 715 dbSNP
rs1475342774 730 dbSNP
rs564320572 731 dbSNP
rs772893567 733 dbSNP
rs1186200438 743 dbSNP
rs528526615 744 dbSNP
rs988716284 746 dbSNP
rs901278084 749 dbSNP
rs768425807 752 dbSNP
rs1251292318 758 dbSNP
rs1479926640 762 dbSNP
rs996607868 768 dbSNP
rs540714671 770 dbSNP
rs1383548347 773 dbSNP
rs1028100967 777 dbSNP
rs1239120586 778 dbSNP
rs1356651454 782 dbSNP
rs114257590 789 dbSNP
rs1010775789 793 dbSNP
rs1395023170 794 dbSNP
rs987179482 800 dbSNP
rs1020904673 807 dbSNP
rs966745389 820 dbSNP
rs911246117 838 dbSNP
rs149071885 841 dbSNP
rs927679018 842 dbSNP
rs1434445321 843 dbSNP
rs959122346 843 dbSNP
rs1436992452 855 dbSNP
rs1272414209 857 dbSNP
rs1176114041 858 dbSNP
rs1372460407 859 dbSNP
rs551158391 860 dbSNP
rs1360260528 868 dbSNP
rs990595328 870 dbSNP
rs35455022 879 dbSNP
rs920086466 880 dbSNP
rs185330045 889 dbSNP
rs767410879 909 dbSNP
rs931506486 911 dbSNP
rs1047222055 915 dbSNP
rs1400671915 924 dbSNP
rs1439888281 925 dbSNP
rs1348965175 935 dbSNP
rs773165906 943 dbSNP
rs1425775769 945 dbSNP
rs533457020 952 dbSNP
rs1369973108 957 dbSNP
rs1219928743 973 dbSNP
rs1294897052 977 dbSNP
rs552094409 979 dbSNP
rs1045785673 987 dbSNP
rs760412492 993 dbSNP
rs766173709 996 dbSNP
rs1469462640 1003 dbSNP
rs1249256481 1011 dbSNP
rs905549559 1013 dbSNP
rs1001677482 1034 dbSNP
rs1201514927 1037 dbSNP
rs908798461 1039 dbSNP
rs1219520604 1046 dbSNP
rs1032794170 1054 dbSNP
rs1259120092 1059 dbSNP
rs957114064 1063 dbSNP
rs1010041788 1069 dbSNP
rs1020144907 1071 dbSNP
rs939993867 1073 dbSNP
rs1041066144 1075 dbSNP
rs767464385 1080 dbSNP
rs1285523914 1083 dbSNP
rs901211912 1085 dbSNP
rs189810707 1090 dbSNP
rs752896660 1099 dbSNP
rs986760006 1104 dbSNP
rs1216962109 1106 dbSNP
rs996869886 1110 dbSNP
rs111490229 1111 dbSNP
rs1468373776 1115 dbSNP
rs1049840406 1135 dbSNP
rs911201684 1138 dbSNP
rs533571721 1145 dbSNP
rs1212201519 1146 dbSNP
rs758542183 1151 dbSNP
rs554964978 1157 dbSNP
rs1489232791 1158 dbSNP
rs893632429 1169 dbSNP
rs1045583 1173 dbSNP
rs368851046 1175 dbSNP
rs1191288419 1189 dbSNP
rs566990134 1193 dbSNP
rs1128487 1196 dbSNP
rs537558728 1216 dbSNP
rs919971907 1218 dbSNP
rs930068992 1228 dbSNP
rs1172813044 1232 dbSNP
rs1189352977 1239 dbSNP
rs751566658 1240 dbSNP
rs1242709063 1253 dbSNP
rs1215350290 1260 dbSNP
rs1047187366 1261 dbSNP
rs1463759811 1265 dbSNP
rs143022891 1270 dbSNP
rs1003590800 1271 dbSNP
rs1323212411 1275 dbSNP
rs1351868996 1288 dbSNP
rs1299857897 1290 dbSNP
rs1437396438 1298 dbSNP
rs1216764657 1300 dbSNP
rs80218046 1302 dbSNP
rs1289001300 1305 dbSNP
rs1433702054 1307 dbSNP
rs553964302 1334 dbSNP
rs990564078 1335 dbSNP
rs920374142 1336 dbSNP
rs1045347195 1337 dbSNP
rs1376819164 1341 dbSNP
rs1401922254 1342 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000233623.5 | 3UTR | AGAUGGGUGGAUCACCUGAGGUCAGGAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000233623.5 | 3UTR | GAUGGGUGGAUCACCUGAGGUCAGGAGUUUGAGACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000233623.5 | 3UTR | AGGCCAAGAUGGGUGGAUCACCUGAGGUCAGGAGUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000233623.5 | 3UTR | CCAAGAUGGGUGGAUCACCUGAGGUCAGGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19350 CNS germ cell tumors -0.682 7.3e-3 -0.147 3.2e-1 12 Click to see details
GSE27834 Pluripotent stem cells 0.578 9.5e-3 0.562 1.2e-2 16 Click to see details
GSE42095 Differentiated embryonic stem cells -0.475 1.1e-2 0.000 5.0e-1 23 Click to see details
GSE21687 Ependynoma primary tumors 0.185 7.2e-2 0.188 6.8e-2 64 Click to see details
GSE28260 Renal cortex and medulla 0.415 7.9e-2 0.433 7.0e-2 13 Click to see details
GSE17498 Multiple myeloma 0.219 8.7e-2 0.203 1.0e-1 40 Click to see details
GSE28544 Breast cancer -0.284 8.9e-2 -0.239 1.3e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.273 9.8e-2 0.330 5.8e-2 24 Click to see details
GSE32688 Pancreatic cancer -0.192 1.5e-1 -0.191 1.5e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.219 1.8e-1 0.104 3.3e-1 20 Click to see details
GSE14794 Lymphoblastoid cells 0.074 2.4e-1 0.063 2.8e-1 90 Click to see details
GSE19536 Breast cancer 0.067 2.5e-1 0.148 7.1e-2 100 Click to see details
GSE38226 Liver fibrosis 0.147 2.6e-1 0.083 3.6e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.123 2.8e-1 -0.220 1.5e-1 25 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.107 3.1e-1 -0.139 2.5e-1 25 Click to see details
GSE17306 Multiple myeloma 0.074 3.1e-1 0.205 7.9e-2 49 Click to see details
GSE19783 ER+ ER+ breast cancer 0.118 3.1e-1 0.128 3.0e-1 20 Click to see details
GSE21849 B cell lymphoma 0.085 3.3e-1 0.250 9.5e-2 29 Click to see details
GSE19783 ER- ER- breast cancer 0.008 4.7e-1 0.105 1.8e-1 79 Click to see details
GSE19783 ER- ER- breast cancer 0.008 4.7e-1 0.105 1.8e-1 79 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-640 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT097121 TNPO1 transportin 1 2 2
MIRT115090 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT204603 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204634 MOB4 MOB family member 4, phocein 2 8
MIRT344451 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT405772 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT445876 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT497418 FAM46A family with sequence similarity 46 member A 2 2
MIRT504394 HMX2 H6 family homeobox 2 2 4
MIRT504691 SLCO2B1 solute carrier organic anion transporter family member 2B1 2 8
MIRT512386 MTRNR2L3 MT-RNR2-like 3 2 6
MIRT513003 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513084 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT519122 ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2 2
MIRT523836 F2RL1 F2R like trypsin receptor 1 2 2
MIRT565356 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT575895 Dis3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT576894 Poteg POTE ankyrin domain family, member G 2 2
MIRT613780 RPS6 ribosomal protein S6 2 2
MIRT613934 POLR3A RNA polymerase III subunit A 2 2
MIRT614348 LOH12CR1 BLOC-1 related complex subunit 5 2 2
MIRT614534 NOA1 nitric oxide associated 1 2 2
MIRT617019 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT618247 MANEAL mannosidase endo-alpha like 2 2
MIRT619051 TTC4 tetratricopeptide repeat domain 4 2 2
MIRT619442 ZNF517 zinc finger protein 517 2 2
MIRT619723 FPR2 formyl peptide receptor 2 2 2
MIRT620179 TRIM72 tripartite motif containing 72 2 2
MIRT620370 ANKRD62 ankyrin repeat domain 62 2 2
MIRT621263 RTN2 reticulon 2 2 2
MIRT621463 APOH apolipoprotein H 2 2
MIRT621571 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT621683 TSPYL1 TSPY like 1 2 2
MIRT622866 PDE7A phosphodiesterase 7A 2 2
MIRT624669 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT625607 ZNF84 zinc finger protein 84 2 2
MIRT626111 IL23R interleukin 23 receptor 2 2
MIRT628380 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT628553 MELK maternal embryonic leucine zipper kinase 2 2
MIRT628671 C2orf72 chromosome 2 open reading frame 72 2 2
MIRT628747 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT628776 TMEM154 transmembrane protein 154 2 2
MIRT628918 ZNF430 zinc finger protein 430 2 2
MIRT629174 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT629209 C12orf66 chromosome 12 open reading frame 66 2 2
MIRT629267 SLC5A8 solute carrier family 5 member 8 2 2
MIRT629498 AS3MT arsenite methyltransferase 2 2
MIRT629665 USP1 ubiquitin specific peptidase 1 2 2
MIRT629760 STK25 serine/threonine kinase 25 2 2
MIRT630899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT631105 SLC15A2 solute carrier family 15 member 2 2 2
MIRT631112 ATCAY ATCAY, caytaxin 2 2
MIRT631450 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT631505 FFAR4 free fatty acid receptor 4 2 2
MIRT631580 ITGAL integrin subunit alpha L 2 2
MIRT631836 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT632342 SWSAP1 SWIM-type zinc finger 7 associated protein 1 2 2
MIRT633214 ZNF584 zinc finger protein 584 2 2
MIRT633223 ZNF43 zinc finger protein 43 2 2
MIRT633480 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT633511 LRRC27 leucine rich repeat containing 27 2 2
MIRT633615 CWF19L1 CWF19 like 1, cell cycle control (S. pombe) 2 2
MIRT633652 SLC28A1 solute carrier family 28 member 1 2 2
MIRT633677 ZNF576 zinc finger protein 576 2 2
MIRT634196 TMOD2 tropomodulin 2 2 4
MIRT634388 PLSCR1 phospholipid scramblase 1 2 2
MIRT635817 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT635962 TTC31 tetratricopeptide repeat domain 31 2 2
MIRT636114 YPEL1 yippee like 1 2 2
MIRT636164 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT636768 CLUAP1 clusterin associated protein 1 2 2
MIRT637092 CXorf23 BCLAF1 and THRAP3 family member 3 2 2
MIRT637316 FAM9B family with sequence similarity 9 member B 2 2
MIRT637540 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT637628 ZNF431 zinc finger protein 431 2 2
MIRT637826 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT637945 IVD isovaleryl-CoA dehydrogenase 2 2
MIRT637968 IRF1 interferon regulatory factor 1 2 2
MIRT638321 RNF11 ring finger protein 11 2 2
MIRT638386 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT639244 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT642608 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT642793 SLC1A5 solute carrier family 1 member 5 2 2
MIRT643847 LACTB lactamase beta 2 4
MIRT644705 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT645148 DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease 2 3
MIRT646671 CCDC69 coiled-coil domain containing 69 2 2
MIRT647780 ASB8 ankyrin repeat and SOCS box containing 8 2 2
MIRT648554 WDR92 WD repeat domain 92 2 2
MIRT648990 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT649099 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT650141 ZNF426 zinc finger protein 426 2 2
MIRT650791 GSR glutathione-disulfide reductase 2 2
MIRT654967 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT655099 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT655516 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 2
MIRT656289 METTL14 methyltransferase like 14 2 2
MIRT656497 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657074 JPH2 junctophilin 2 2 2
MIRT657314 HOOK3 hook microtubule tethering protein 3 2 2
MIRT657419 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 4
MIRT659032 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659535 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT661532 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT662029 FUT2 fucosyltransferase 2 2 2
MIRT663206 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT663357 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT663557 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663650 POLM DNA polymerase mu 2 2
MIRT663694 ABHD17B abhydrolase domain containing 17B 2 2
MIRT664370 CYB5A cytochrome b5 type A 2 2
MIRT664783 LIAS lipoic acid synthetase 2 4
MIRT665561 TXNL1 thioredoxin like 1 2 2
MIRT665950 TAOK1 TAO kinase 1 2 2
MIRT667338 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT667804 ITIH5 inter-alpha-trypsin inhibitor heavy chain family member 5 2 2
MIRT668804 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT669470 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT669599 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT669806 STOML1 stomatin like 1 2 2
MIRT669944 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT670292 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT670381 EMP2 epithelial membrane protein 2 2 2
MIRT670481 DCUN1D2 defective in cullin neddylation 1 domain containing 2 2 2
MIRT670531 KIF1C kinesin family member 1C 2 4
MIRT670565 GLTP glycolipid transfer protein 2 2
MIRT670603 NPHP1 nephrocystin 1 2 2
MIRT670880 CYTIP cytohesin 1 interacting protein 2 2
MIRT670931 LIPG lipase G, endothelial type 2 2
MIRT671261 MTRNR2L5 MT-RNR2-like 5 2 2
MIRT671794 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 2 2
MIRT671897 GBP4 guanylate binding protein 4 2 2
MIRT672000 SLC35F6 solute carrier family 35 member F6 2 4
MIRT672074 KIR3DX1 killer cell immunoglobulin like receptor, three Ig domains X1 2 2
MIRT672319 C9orf3 chromosome 9 open reading frame 3 2 2
MIRT672853 C22orf29 retrotransposon Gag like 10 2 2
MIRT673395 WNT7B Wnt family member 7B 2 2
MIRT673537 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT674285 ZNF724P zinc finger protein 724 2 2
MIRT674494 TIRAP TIR domain containing adaptor protein 2 2
MIRT675460 NUBPL nucleotide binding protein like 2 2
MIRT675569 TRIP11 thyroid hormone receptor interactor 11 2 2
MIRT676068 TIMM50 translocase of inner mitochondrial membrane 50 2 2
MIRT676254 PBOV1 prostate and breast cancer overexpressed 1 2 2
MIRT676377 SEC24D SEC24 homolog D, COPII coat complex component 2 2
MIRT676758 SNX2 sorting nexin 2 2 2
MIRT676773 NPHS1 NPHS1, nephrin 2 2
MIRT676874 ENSA endosulfine alpha 2 2
MIRT676918 KLHDC8A kelch domain containing 8A 2 2
MIRT676944 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT676957 HFE hemochromatosis 2 2
MIRT676967 RNF19B ring finger protein 19B 2 2
MIRT676972 ZNF708 zinc finger protein 708 2 2
MIRT677042 ZNF34 zinc finger protein 34 2 2
MIRT677070 VMAC vimentin type intermediate filament associated coiled-coil protein 2 2
MIRT677093 MFSD11 major facilitator superfamily domain containing 11 2 4
MIRT677134 P2RX7 purinergic receptor P2X 7 2 2
MIRT677179 ZNF786 zinc finger protein 786 2 2
MIRT677228 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT677320 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT677455 PDLIM3 PDZ and LIM domain 3 2 2
MIRT677809 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT677937 ZNF519 zinc finger protein 519 2 2
MIRT678063 UBN2 ubinuclein 2 2 4
MIRT678072 EIF2A eukaryotic translation initiation factor 2A 2 2
MIRT678252 FXN frataxin 2 2
MIRT678315 FBLIM1 filamin binding LIM protein 1 2 2
MIRT678367 XIAP X-linked inhibitor of apoptosis 2 4
MIRT678372 RNF115 ring finger protein 115 2 2
MIRT678410 ANKRD36 ankyrin repeat domain 36 2 2
MIRT678518 ZNF347 zinc finger protein 347 2 2
MIRT678566 CDK4 cyclin dependent kinase 4 2 2
MIRT678580 PPP1R3B protein phosphatase 1 regulatory subunit 3B 2 2
MIRT678820 PDE6A phosphodiesterase 6A 2 2
MIRT678917 XPOT exportin for tRNA 2 2
MIRT679217 MAN2A2 mannosidase alpha class 2A member 2 2 2
MIRT679437 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT679595 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT679755 TLR6 toll like receptor 6 2 2
MIRT679800 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 2 2
MIRT680057 CD96 CD96 molecule 2 2
MIRT680116 CCDC30 coiled-coil domain containing 30 2 4
MIRT680181 ZNF554 zinc finger protein 554 2 2
MIRT680439 WDR12 WD repeat domain 12 2 2
MIRT680789 ZNF578 zinc finger protein 578 2 2
MIRT692464 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT702952 HIP1 huntingtin interacting protein 1 2 2
MIRT706016 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT706032 F2R coagulation factor II thrombin receptor 2 2
MIRT706135 MTRNR2L10 MT-RNR2-like 10 2 2
MIRT706394 HAS2 hyaluronan synthase 2 2 2
MIRT713293 DCP2 decapping mRNA 2 2 2
MIRT716583 BRAP BRCA1 associated protein 2 2
MIRT720433 C19orf47 chromosome 19 open reading frame 47 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-640 Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer tissue and cell line (SKOV3)
hsa-miR-640 Cetuximab resistant High Colon Cancer cell line
hsa-miR-640 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-640 Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-640 Sorafenib 216239 NSC747971 approved sensitive Low Clear Cell Renal Cell Carcinoma cell line (786-O)
hsa-mir-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-640 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-640 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-640 Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-640 Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-640 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-640 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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