pre-miRNA Information
pre-miRNA hsa-mir-6511b-1   
Genomic Coordinates chr16: 2106669 - 2106753
Description Homo sapiens miR-6511b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511b-2   
Genomic Coordinates chr16: 15134075 - 15134145
Description Homo sapiens miR-6511b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6511b-3p
Sequence 53| CCUCACCACCCCUUCUGCCUGCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
993639 5 ClinVar
1196654 15 ClinVar
256998 15 ClinVar
433980 16 ClinVar
586295 18 ClinVar
433979 19 ClinVar
COSM3948368 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs769351879 1 dbSNP
rs1001283562 2 dbSNP
rs763611191 3 dbSNP
rs1465530682 4 dbSNP
rs1227492873 4 dbSNP
rs745502224 5 dbSNP
rs551972801 6 dbSNP
rs538162642 6 dbSNP
rs751438298 7 dbSNP
rs1285683081 7 dbSNP
rs1340898267 8 dbSNP
rs4018164 9 dbSNP
rs370568831 9 dbSNP
rs1180919709 10 dbSNP
rs1339482497 10 dbSNP
rs758216756 11 dbSNP
rs1323026290 11 dbSNP
rs1239445091 12 dbSNP
rs1310601001 12 dbSNP
rs1431093969 13 dbSNP
rs752690118 15 dbSNP
rs1371790714 15 dbSNP
rs746463189 16 dbSNP
rs1209415208 17 dbSNP
rs761022804 17 dbSNP
rs1242038386 17 dbSNP
rs370411414 18 dbSNP
rs759723934 19 dbSNP
rs1428318191 19 dbSNP
rs1416441031 20 dbSNP
rs754040914 21 dbSNP
rs776062795 21 dbSNP
rs1273686335 22 dbSNP
rs1182772456 22 dbSNP
rs1472619959 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZDHHC22   
Synonyms C14orf59
Description zinc finger DHHC-type containing 22
Transcript NM_174976   
Expression
Putative miRNA Targets on ZDHHC22
3'UTR of ZDHHC22
(miRNA target sites are highlighted)
>ZDHHC22|NM_174976|3'UTR
   1 TAGACACTCCCGTCATTTATCTCTCTGTCTCTGTCTTGACTCCTCCTGAGCATAAAACCATGGCAGCCTTGTCTCCACCC
  81 ATGACTCACTACAACCTTGTGCTGGTAAGGTCCTAGCATCTTCCCCTCACCTTCCACCCATGAGAACAGCGTGAGCTGGT
 161 GGATCATGACAAGGAGGAAAAATGTCCCCCCAGGCATTTCTAGGCTCCTCACGAGCCAGCCAGGTGGCTGCTAGCTGTTA
 241 GGCTGCCTCTGCTTTCTTTCCGTCCCCTTGGGATCCCTGCTTTCCCCCTCTTCCTGGCTCATCCATTCTCCACCGTGTCT
 321 CATTCATCACTGCTGTCTGCTAGAGCCCTTCCTCTCAGCCCCCATGTTGGGAGAGGGGAGTGGATTCTTGCTGCTGGTAT
 401 GAGACTCCCTGGGACCTAGAGGCTGGCAAATGTTTAAAATCACCACGTGTAAGAGGCAGCCAAGTCAGCTCTGCCAACTG
 481 CTAGGGGAGTTGGGAAAGAGTGGGTGTGTGTCCGCATCCCCTCTGTAGGAAAAAGAACTTAGTAGCTTGCTGCTCCCTCA
 561 CCACCCCCCACCAGGTTCAAGACCCTTTTTCTGGGAGACAGCAATCAATGGCCTGCTTTTTCCAAATGTTATTCCCTGTC
 641 CACCCTGCCCCATCTGGCCGGCCCAGCCCAGTCCAGGACCTGGCTGGATGCTTCCTGTCCCTGGAACTCTTCCAGCCTTT
 721 CTACTTGATCTCCAGCCCCCAGGTCTTTGCCAGATGATGGGAAGGCAAGGAAGAAGGGACAGGGAAAGATAATTACTGAT
 801 AAATGAAGGGGATATTCGACTGTATAACCATATGGAAGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAGAGAGAGAGAGAG
 881 AGAGATGGGTGGTGGTGAGAAGTGTTGTTAGAAACATATAGGAATAATGCCTAGGGGAAAGGGAGAAGTGAGAGGGACAA
 961 TTGGGTTCATTTATGCCCTATACAAAGGGCATTCCAGCAGCTGAAACTCTTCAATGTTTGAATGGCTGCCTGTGAAGGTA
1041 GTGAGTGCCCCATCACTGGAGGTATTCCAGCAGAGTCTAGGCAGTCGTCTGCCAGGCATGCTGTGGAAGGGATTTCTGTA
1121 CAGGGTCATTCTAGGTGAGCTTACACATTCCTTCCAACCCCAAGGTTCTGATGTCCTGGTTGTGATTGCTGGACCCAGAG
1201 GCAAGATCTGCAGAGATGCCTGTGAGATATTTGCTTTCCTAGAGGGGAGTGTGGGCATGGGAGGGGTCTGAAAATCAGGA
1281 CCCAACCCAGCCACTGAAGAGAGAGTCTCTGCAGAGACAGGGCTACCTGGGTGGTTGAGGGGACTGACATTTGAGGACAG
1361 GGAGATGGAGCAGTGTCATTGTCAGTGGCAGGGCATGGGGGGCAGTGGTGAGCTAAGGCTGAGGAGTGGAGATGACCAGA
1441 ATATAAGGGTGCAATTCCCAGACCATCCCTGCGCATCTGACTGACTCCGGTGGAGGCACTGCTGTGTGTTTTCTGAAACC
1521 TAGAGGACCAGACCTCTGGGGCATATAAGGGAGTAGGGACAACACAAGTGCCCCCTCCTGACTGGGTCCCAAAGCCAATA
1601 TGACATCCATGCAGGCAGCAGTGCTGAATCCATGCCCTGCAATGTCCAACCGCCAACTGCAGTGACCCGCTGATAGCTGC
1681 GCAACAGCCTGGGTTCTTGAGCAGAGATTGGGAGGACTTTACTGTGGTTCTGCCTTCACACCCCCTAGAGAGCTAATGTA
1761 GTATTGGCTCCACCTGCTCACATTTCTCCCTCCCATACTCATTCCTTCACTCATCCATCCTACGTATATTTATTGAGTGC
1841 CAACTACGTTCCCAGCCTCTTCCAGGCACTGGCAATGCAGTGATGAACAGGATGACAAGATTCATGCCATCAGGGGCACC
1921 TTGTCACTGCCGTCTGTGCACTGATTCACACTCCCTGCAAAATGGTCACTCTGCCATCTTGGTGGTTGGTGGGGCAGGTC
2001 ATTTGGAAATAAAGAATGTGATAGAGATGGCTGAAGAGGGGAAGCCTAGGCTGCCTCAATGGAGGAGTCGCTGGGGGCAT
2081 TTTCACCCACAATTCTGGCCATACTTAAGCAATGGGAGGGAGAGGGAGGAGGGGAAGATCTGGGCAATTTTGGCCTTGAC
2161 TCTTTCCTGGCTCCAGAGCTCAAGCTTAGAAGCCAGCCCTGCTATTTCCAGCCTCCTGAAGGCTCAGCACGGTGAGGCCT
2241 GACATCCTGGGGAAGGGCAACAGGGAGACCTACAGGATGTTGGCTGCTTGCAGACTGGTCAATGGGGGATGACGGTGGGG
2321 AGGTTGCCAGATGTGAGACTTGAGTAGCATTTGTACACATGGCCCTGTATTGTCCTTGAAGAACATCAATAAAATATATG
2401 GTTTTAAATTGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGU-CCGU-CUUCCC--CACCACUCc 5'
            || |||| |::|||  |||||||| 
Target 5' ggCAGGGCATGGGGGGCAGTGGTGAGc 3'
1387 - 1413 171.00 -30.30
2
miRNA  3' acgUCCGUCUUCC--CCACCACUCc 5'
             ||  ||| ||  ||||||||| 
Target 5' gagAGAGAGATGGGTGGTGGTGAGa 3'
876 - 900 166.00 -22.30
3
miRNA  3' acguccgucuucCCCACCACUCc 5'
                      || |||||:| 
Target 5' tgccatcttggtGGTTGGTGGGg 3'
1972 - 1994 131.00 -17.74
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26134186 9 COSMIC
COSN30455030 11 COSMIC
COSN30505580 11 COSMIC
COSN31569526 23 COSMIC
COSN31612068 29 COSMIC
COSN30188207 51 COSMIC
COSN31559287 112 COSMIC
COSN30742955 136 COSMIC
COSN6543003 194 COSMIC
COSN30534515 201 COSMIC
COSN28085504 237 COSMIC
COSN20111508 865 COSMIC
COSN16278086 869 COSMIC
COSN19044874 1101 COSMIC
COSN7026966 1248 COSMIC
COSN5750911 1745 COSMIC
COSN8850424 2069 COSMIC
COSN8850423 2097 COSMIC
COSN21837174 2216 COSMIC
COSN24186971 2314 COSMIC
COSN22580690 2326 COSMIC
COSN19462383 2362 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1272915567 5 dbSNP
rs756765997 6 dbSNP
rs746638897 11 dbSNP
rs369098841 12 dbSNP
rs907795526 24 dbSNP
rs983372914 26 dbSNP
rs1374302723 27 dbSNP
rs769555156 33 dbSNP
rs1440110838 45 dbSNP
rs187121162 49 dbSNP
rs1037186464 52 dbSNP
rs1314504174 59 dbSNP
rs940432826 63 dbSNP
rs907664416 74 dbSNP
rs1336471926 76 dbSNP
rs1272616603 78 dbSNP
rs1048711134 81 dbSNP
rs1278065074 88 dbSNP
rs1371586316 89 dbSNP
rs1350250868 95 dbSNP
rs772416161 102 dbSNP
rs142698447 105 dbSNP
rs1000338886 108 dbSNP
rs530292714 115 dbSNP
rs1251865401 120 dbSNP
rs1331125254 125 dbSNP
rs1410781779 134 dbSNP
rs561294049 140 dbSNP
rs1362800113 142 dbSNP
rs1478153289 147 dbSNP
rs911700247 150 dbSNP
rs556867757 151 dbSNP
rs1308632093 153 dbSNP
rs1397283924 162 dbSNP
rs956104894 170 dbSNP
rs1393157508 172 dbSNP
rs1033095287 181 dbSNP
rs1178630528 186 dbSNP
rs1468922507 190 dbSNP
rs1235004978 192 dbSNP
rs1335358440 193 dbSNP
rs1235331347 196 dbSNP
rs1306051309 200 dbSNP
rs1346213633 205 dbSNP
rs544711526 207 dbSNP
rs1010470411 213 dbSNP
rs1252463440 216 dbSNP
rs1481914395 217 dbSNP
rs760835219 218 dbSNP
rs575610899 223 dbSNP
rs368097326 226 dbSNP
rs1249245608 230 dbSNP
rs75688671 261 dbSNP
rs779110226 262 dbSNP
rs1393032707 264 dbSNP
rs1276100162 268 dbSNP
rs1453636295 277 dbSNP
rs1212319444 286 dbSNP
rs757820682 291 dbSNP
rs1347988893 300 dbSNP
rs866718618 303 dbSNP
rs1323696546 305 dbSNP
rs1237952006 311 dbSNP
rs749784690 313 dbSNP
rs1279870813 315 dbSNP
rs1369216496 316 dbSNP
rs1447054158 321 dbSNP
rs1014905128 335 dbSNP
rs1440552438 338 dbSNP
rs1358730705 347 dbSNP
rs1311303664 350 dbSNP
rs931930071 353 dbSNP
rs900605812 363 dbSNP
rs896100204 365 dbSNP
rs1250237972 366 dbSNP
rs1037758363 367 dbSNP
rs576769601 375 dbSNP
rs539353349 378 dbSNP
rs1215163025 397 dbSNP
rs1004377744 404 dbSNP
rs1467759869 411 dbSNP
rs1376208089 419 dbSNP
rs1263615830 424 dbSNP
rs886150852 426 dbSNP
rs866317032 427 dbSNP
rs762371208 447 dbSNP
rs907679540 466 dbSNP
rs1169700708 468 dbSNP
rs1372572255 477 dbSNP
rs148491715 483 dbSNP
rs930303505 485 dbSNP
rs921576205 487 dbSNP
rs3742741 499 dbSNP
rs1461149235 508 dbSNP
rs949325858 513 dbSNP
rs115264386 514 dbSNP
rs1295569596 515 dbSNP
rs371389073 517 dbSNP
rs1356674964 523 dbSNP
rs944612804 526 dbSNP
rs1234522140 528 dbSNP
rs959008516 530 dbSNP
rs1032065885 535 dbSNP
rs911851050 543 dbSNP
rs988601759 545 dbSNP
rs11621913 550 dbSNP
rs955863538 552 dbSNP
rs1284737783 553 dbSNP
rs926001216 562 dbSNP
rs1190104952 564 dbSNP
rs1318610977 567 dbSNP
rs978861419 569 dbSNP
rs756443538 574 dbSNP
rs753060599 580 dbSNP
rs1023375989 583 dbSNP
rs571146654 591 dbSNP
rs1288660909 597 dbSNP
rs1376556906 604 dbSNP
rs1417190281 615 dbSNP
rs960567206 618 dbSNP
rs1354318779 623 dbSNP
rs1223986266 628 dbSNP
rs969315476 629 dbSNP
rs1291660277 633 dbSNP
rs1020443219 634 dbSNP
rs1015802469 639 dbSNP
rs574314010 641 dbSNP
rs752703 642 dbSNP
rs534373002 654 dbSNP
rs764528712 656 dbSNP
rs1027132478 659 dbSNP
rs994982156 661 dbSNP
rs373267387 662 dbSNP
rs900282430 666 dbSNP
rs567030555 668 dbSNP
rs369501265 669 dbSNP
rs944388575 670 dbSNP
rs1037810896 679 dbSNP
rs552190428 685 dbSNP
rs1358055975 688 dbSNP
rs890340896 698 dbSNP
rs1053035186 700 dbSNP
rs1262059277 719 dbSNP
rs942121520 727 dbSNP
rs1184189123 728 dbSNP
rs934460583 729 dbSNP
rs1231975638 733 dbSNP
rs1486568910 734 dbSNP
rs1438332732 735 dbSNP
rs1242617063 736 dbSNP
rs1234698950 738 dbSNP
rs1479769130 743 dbSNP
rs1220826232 752 dbSNP
rs886307608 758 dbSNP
rs765839034 760 dbSNP
rs1332366947 762 dbSNP
rs925761208 765 dbSNP
rs1047567669 766 dbSNP
rs1411041975 770 dbSNP
rs949203716 777 dbSNP
rs1352310366 781 dbSNP
rs145458421 783 dbSNP
rs1372742618 790 dbSNP
rs1438357660 800 dbSNP
rs948809349 802 dbSNP
rs182835649 807 dbSNP
rs916037424 810 dbSNP
rs763159289 817 dbSNP
rs990669587 818 dbSNP
rs1216310293 820 dbSNP
rs993199311 823 dbSNP
rs547335875 825 dbSNP
rs1277815443 828 dbSNP
rs1380547308 833 dbSNP
rs1364246776 835 dbSNP
rs1289964540 836 dbSNP
rs1275174640 837 dbSNP
rs375230791 838 dbSNP
rs1305909255 850 dbSNP
rs866429110 852 dbSNP
rs960076671 853 dbSNP
rs1392711547 855 dbSNP
rs1328286364 857 dbSNP
rs370703937 859 dbSNP
rs149602941 861 dbSNP
rs140188712 863 dbSNP
rs144140985 865 dbSNP
rs367639970 866 dbSNP
rs1165016141 867 dbSNP
rs1491459943 867 dbSNP
rs376434680 867 dbSNP
rs4021329 867 dbSNP
rs888061 867 dbSNP
rs1423066568 869 dbSNP
rs867679749 869 dbSNP
rs1167454330 871 dbSNP
rs1330992427 871 dbSNP
rs1348484646 878 dbSNP
rs1457668315 883 dbSNP
rs1289821567 886 dbSNP
rs1387724723 886 dbSNP
rs142042377 886 dbSNP
rs1342652528 887 dbSNP
rs1458811667 887 dbSNP
rs1190528029 890 dbSNP
rs1467043192 891 dbSNP
rs1254844678 893 dbSNP
rs952994137 894 dbSNP
rs1027101260 895 dbSNP
rs370449827 899 dbSNP
rs1382596220 928 dbSNP
rs375019907 929 dbSNP
rs1418405183 932 dbSNP
rs1457167553 933 dbSNP
rs561543111 935 dbSNP
rs1416021450 941 dbSNP
rs1017359653 945 dbSNP
rs1300604631 950 dbSNP
rs1225607095 961 dbSNP
rs1309302838 965 dbSNP
rs1391658969 974 dbSNP
rs1296449271 980 dbSNP
rs1351315051 986 dbSNP
rs1239318964 1001 dbSNP
rs550850875 1002 dbSNP
rs531082828 1014 dbSNP
rs1349967901 1022 dbSNP
rs548730910 1025 dbSNP
rs1369374888 1029 dbSNP
rs762474758 1033 dbSNP
rs1235828640 1034 dbSNP
rs1483031104 1041 dbSNP
rs1178064506 1046 dbSNP
rs1240401666 1048 dbSNP
rs1438160042 1049 dbSNP
rs1158425772 1052 dbSNP
rs1396171735 1052 dbSNP
rs1442079219 1056 dbSNP
rs1052796448 1061 dbSNP
rs1400109058 1067 dbSNP
rs934553482 1070 dbSNP
rs1416679735 1081 dbSNP
rs966494291 1086 dbSNP
rs904475906 1087 dbSNP
rs565226804 1092 dbSNP
rs1374218191 1094 dbSNP
rs1174692377 1095 dbSNP
rs989011842 1096 dbSNP
rs955013536 1098 dbSNP
rs1217446339 1109 dbSNP
rs1030615778 1110 dbSNP
rs948584508 1116 dbSNP
rs773036084 1117 dbSNP
rs964743936 1119 dbSNP
rs1456633738 1127 dbSNP
rs1178356812 1134 dbSNP
rs1016263835 1144 dbSNP
rs992940098 1150 dbSNP
rs377399724 1157 dbSNP
rs1006602822 1160 dbSNP
rs886529318 1165 dbSNP
rs1409985977 1167 dbSNP
rs765154942 1171 dbSNP
rs1172199341 1172 dbSNP
rs545036629 1173 dbSNP
rs1464800087 1182 dbSNP
rs1248203128 1189 dbSNP
rs938791382 1190 dbSNP
rs1274917624 1193 dbSNP
rs1481713070 1195 dbSNP
rs1434193879 1201 dbSNP
rs1252140987 1212 dbSNP
rs1362575813 1229 dbSNP
rs1215195057 1233 dbSNP
rs530638153 1235 dbSNP
rs1345889604 1241 dbSNP
rs572881451 1249 dbSNP
rs1009030662 1285 dbSNP
rs879597149 1287 dbSNP
rs952961557 1307 dbSNP
rs1054991649 1326 dbSNP
rs191739417 1331 dbSNP
rs975951701 1337 dbSNP
rs74069083 1347 dbSNP
rs1305242058 1348 dbSNP
rs945013039 1350 dbSNP
rs1477288753 1362 dbSNP
rs1165268166 1365 dbSNP
rs913663615 1379 dbSNP
rs1017745899 1386 dbSNP
rs986939742 1391 dbSNP
rs1322684105 1395 dbSNP
rs1008631285 1401 dbSNP
rs1393529394 1403 dbSNP
rs574598318 1407 dbSNP
rs186908464 1417 dbSNP
rs954475284 1419 dbSNP
rs1031335609 1423 dbSNP
rs1373519173 1424 dbSNP
rs954879349 1426 dbSNP
rs1218237823 1436 dbSNP
rs998562911 1437 dbSNP
rs1284946430 1441 dbSNP
rs1358748427 1449 dbSNP
rs904402527 1472 dbSNP
rs544065371 1473 dbSNP
rs772469308 1474 dbSNP
rs1219485203 1477 dbSNP
rs117502738 1481 dbSNP
rs1487642094 1487 dbSNP
rs369054203 1488 dbSNP
rs558345229 1489 dbSNP
rs1471617375 1499 dbSNP
rs950751016 1510 dbSNP
rs1183673491 1516 dbSNP
rs538705596 1524 dbSNP
rs1408485979 1526 dbSNP
rs4903545 1535 dbSNP
rs749325495 1539 dbSNP
rs1359841041 1544 dbSNP
rs1399412481 1554 dbSNP
rs1014069014 1560 dbSNP
rs1187584066 1566 dbSNP
rs1484713553 1568 dbSNP
rs1283941454 1572 dbSNP
rs896363763 1573 dbSNP
rs1047010840 1576 dbSNP
rs1282621781 1577 dbSNP
rs1284418142 1578 dbSNP
rs1353657998 1580 dbSNP
rs778213762 1582 dbSNP
rs1211711340 1583 dbSNP
rs920141445 1585 dbSNP
rs1259489267 1597 dbSNP
rs1241554972 1604 dbSNP
rs1186478362 1622 dbSNP
rs1233234974 1631 dbSNP
rs1441259302 1641 dbSNP
rs139506830 1644 dbSNP
rs975707148 1646 dbSNP
rs1412591219 1647 dbSNP
rs964671545 1649 dbSNP
rs1173214657 1650 dbSNP
rs2041822 1651 dbSNP
rs112249103 1652 dbSNP
rs565087948 1653 dbSNP
rs78191721 1659 dbSNP
rs551198596 1668 dbSNP
rs1167168435 1669 dbSNP
rs998489344 1672 dbSNP
rs1050901685 1679 dbSNP
rs933718523 1680 dbSNP
rs920979231 1681 dbSNP
rs1199405650 1685 dbSNP
rs1258233037 1686 dbSNP
rs1458840492 1693 dbSNP
rs1196476146 1704 dbSNP
rs974912025 1708 dbSNP
rs1454636418 1715 dbSNP
rs964853476 1727 dbSNP
rs376620396 1739 dbSNP
rs1367719476 1740 dbSNP
rs1467422476 1741 dbSNP
rs115272500 1742 dbSNP
rs1021937763 1744 dbSNP
rs373595119 1745 dbSNP
rs1231841741 1747 dbSNP
rs992238123 1757 dbSNP
rs183725206 1758 dbSNP
rs765996327 1762 dbSNP
rs1033700900 1766 dbSNP
rs1196417432 1778 dbSNP
rs1002005856 1782 dbSNP
rs1446510146 1785 dbSNP
rs2041821 1792 dbSNP
rs375103987 1794 dbSNP
rs1002663540 1795 dbSNP
rs1265131694 1801 dbSNP
rs887157698 1802 dbSNP
rs12897402 1806 dbSNP
rs1351812946 1816 dbSNP
rs892163960 1817 dbSNP
rs543171734 1822 dbSNP
rs191858329 1823 dbSNP
rs530042552 1824 dbSNP
rs942960272 1834 dbSNP
rs912847177 1837 dbSNP
rs1039446764 1839 dbSNP
rs561008822 1840 dbSNP
rs1293533529 1843 dbSNP
rs986929397 1844 dbSNP
rs1298243643 1847 dbSNP
rs186276236 1847 dbSNP
rs575891025 1848 dbSNP
rs1321981330 1863 dbSNP
rs1483368093 1869 dbSNP
rs1320170901 1881 dbSNP
rs1263506504 1885 dbSNP
rs985099217 1891 dbSNP
rs1382757215 1893 dbSNP
rs1263977583 1902 dbSNP
rs1489276830 1911 dbSNP
rs575368743 1912 dbSNP
rs977188377 1917 dbSNP
rs968896675 1919 dbSNP
rs558748598 1923 dbSNP
rs1462818885 1931 dbSNP
rs1021282583 1932 dbSNP
rs919483356 1938 dbSNP
rs1367130547 1940 dbSNP
rs991602385 1957 dbSNP
rs958609014 1960 dbSNP
rs1035579265 1976 dbSNP
rs116302291 1978 dbSNP
rs572931405 1979 dbSNP
rs1371450951 1984 dbSNP
rs747851602 1988 dbSNP
rs1195930250 1990 dbSNP
rs1397457045 1997 dbSNP
rs1310303280 1998 dbSNP
rs1320952103 2002 dbSNP
rs1240613727 2005 dbSNP
rs553054541 2016 dbSNP
rs960664923 2021 dbSNP
rs1351465781 2022 dbSNP
rs1448034922 2024 dbSNP
rs1260272722 2030 dbSNP
rs117430319 2031 dbSNP
rs1183888174 2045 dbSNP
rs1254495004 2047 dbSNP
rs1033754712 2050 dbSNP
rs1179690478 2058 dbSNP
rs1382650373 2059 dbSNP
rs1418460056 2066 dbSNP
rs55734127 2068 dbSNP
rs967944452 2069 dbSNP
rs113703943 2070 dbSNP
rs368238956 2076 dbSNP
rs1039706976 2078 dbSNP
rs942699706 2086 dbSNP
rs891344410 2088 dbSNP
rs1377990355 2111 dbSNP
rs1447201223 2113 dbSNP
rs1311218735 2120 dbSNP
rs537723098 2126 dbSNP
rs1213668663 2129 dbSNP
rs1336853301 2140 dbSNP
rs1239390150 2141 dbSNP
rs1271380150 2147 dbSNP
rs892378124 2165 dbSNP
rs1029558672 2170 dbSNP
rs935463416 2173 dbSNP
rs924088142 2175 dbSNP
rs1199640182 2186 dbSNP
rs899488486 2193 dbSNP
rs1039497315 2194 dbSNP
rs1370070243 2196 dbSNP
rs1426495325 2197 dbSNP
rs1434326876 2213 dbSNP
rs1301170734 2215 dbSNP
rs1173379587 2219 dbSNP
rs941086902 2220 dbSNP
rs1465863206 2223 dbSNP
rs545373557 2230 dbSNP
rs1395035338 2231 dbSNP
rs1445938545 2237 dbSNP
rs1324422087 2239 dbSNP
rs1409661429 2241 dbSNP
rs887986966 2249 dbSNP
rs979629269 2256 dbSNP
rs929467163 2257 dbSNP
rs1323052373 2259 dbSNP
rs1450176275 2265 dbSNP
rs571763152 2269 dbSNP
rs919514943 2281 dbSNP
rs1456672788 2284 dbSNP
rs1204269412 2285 dbSNP
rs1489769351 2286 dbSNP
rs1188930877 2287 dbSNP
rs1428042925 2297 dbSNP
rs1477943101 2302 dbSNP
rs1172446398 2303 dbSNP
rs1421039064 2305 dbSNP
rs992356123 2308 dbSNP
rs939377824 2311 dbSNP
rs947154743 2313 dbSNP
rs760491182 2314 dbSNP
rs1202259965 2319 dbSNP
rs866044137 2322 dbSNP
rs1192369497 2329 dbSNP
rs1455831399 2337 dbSNP
rs968544653 2344 dbSNP
rs991136230 2346 dbSNP
rs915288056 2362 dbSNP
rs1316327137 2369 dbSNP
rs1204292622 2374 dbSNP
rs958626256 2381 dbSNP
rs1035545215 2384 dbSNP
rs1435670947 2385 dbSNP
rs1220095936 2386 dbSNP
rs981304736 2392 dbSNP
rs1267542102 2397 dbSNP
rs1488298801 2399 dbSNP
rs1274677970 2402 dbSNP
rs951326435 2406 dbSNP
rs956539700 2409 dbSNP
rs1025425409 2410 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGAUGGGUGGUGGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000319374.4 | 3UTR | UAUGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGAUGGGUGGUGGUGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000319374.4 | 3UTR | UGGAAGUGUGUGUGUGUGUGUGUGUGUGUGUGUGAGAGAGAGAGAGAGAGAGAUGGGUGGUGGUGAGAAGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-6511b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059269 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061287 IPO7 importin 7 2 2
MIRT115533 MAZ MYC associated zinc finger protein 2 2
MIRT345986 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT379536 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT442491 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 2 8
MIRT443701 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT459167 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT497179 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT497846 GATA6 GATA binding protein 6 2 4
MIRT519625 ZNF781 zinc finger protein 781 2 2
MIRT519838 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT528560 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT530718 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530810 GPR182 G protein-coupled receptor 182 2 2
MIRT533265 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT533726 TMEM246 transmembrane protein 246 2 2
MIRT535547 P2RY2 purinergic receptor P2Y2 2 2
MIRT536019 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539494 ACTN4 actinin alpha 4 2 2
MIRT541793 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 8
MIRT554509 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT558784 CEP55 centrosomal protein 55 2 2
MIRT560013 ZNF525 zinc finger protein 525 2 2
MIRT560078 ZNF195 zinc finger protein 195 2 2
MIRT570135 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570890 ZNF780A zinc finger protein 780A 2 2
MIRT607972 SNX22 sorting nexin 22 2 2
MIRT608104 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT610471 ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 2 4
MIRT611134 GGT7 gamma-glutamyltransferase 7 2 2
MIRT611448 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT613019 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT615753 C6 complement C6 2 2
MIRT620464 CERS6 ceramide synthase 6 2 2
MIRT632248 VPS41 VPS41, HOPS complex subunit 2 2
MIRT636099 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637452 ZNF324B zinc finger protein 324B 2 2
MIRT638927 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT646768 WDR3 WD repeat domain 3 2 2
MIRT652610 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT652868 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT653655 SLC27A4 solute carrier family 27 member 4 2 2
MIRT657089 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657884 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT662919 MED18 mediator complex subunit 18 2 2
MIRT685622 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687427 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692304 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT695127 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695144 PRY PTPN13-like, Y-linked 2 2
MIRT696286 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT699350 SLC35E1 solute carrier family 35 member E1 2 2
MIRT709901 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT710877 SLC25A42 solute carrier family 25 member 42 2 2
MIRT711365 MED7 mediator complex subunit 7 2 2
MIRT711444 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT713221 RCAN2 regulator of calcineurin 2 2 2
MIRT713281 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT714195 TRAF7 TNF receptor associated factor 7 2 2
MIRT715152 IL12B interleukin 12B 2 2
MIRT719197 CASP10 caspase 10 2 2
MIRT719469 SRF serum response factor 2 2
MIRT720197 MPP6 membrane palmitoylated protein 6 2 2
MIRT720449 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720461 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721646 ZNF207 zinc finger protein 207 2 2
MIRT722001 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT725521 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6511b-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-6511b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6511b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6511b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6511b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

Error report submission