pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol THBD   
Synonyms AHUS6, BDCA3, CD141, THPH12, THRM, TM
Description thrombomodulin
Transcript NM_000361   
Expression
Putative miRNA Targets on THBD
3'UTR of THBD
(miRNA target sites are highlighted)
>THBD|NM_000361|3'UTR
   1 GCGGCCTCCGTCCAGGAGCCTGGCTCCGTCCAGGAGCCTGTGCCTCCTCACCCCCAGCTTTGCTACCAAAGCACCTTAGC
  81 TGGCATTACAGCTGGAGAAGACCCTCCCCGCACCCCCCAAGCTGTTTTCTTCTATTCCATGGCTAACTGGCGAGGGGGTG
 161 ATTAGAGGGAGGAGAATGAGCCTCGGCCTCTTCCGTGACGTCACTGGACCACTGGGCAATGATGGCAATTTTGTAACGAA
 241 GACACAGACTGCGATTTGTCCCAGGTCCTCACTACCGGGCGCAGGAGGGTGAGCGTTATTGGTCGGCAGCCTTCTGGGCA
 321 GACCTTGACCTCGTGGGCTAGGGATGACTAAAATATTTATTTTTTTTAAGTATTTAGGTTTTTGTTTGTTTCCTTTGTTC
 401 TTACCTGTATGTCTCCAGTATCCACTTTGCACAGCTCTCCGGTCTCTCTCTCTCTACAAACTCCCACTTGTCATGTGACA
 481 GGTAAACTATCTTGGTGAATTTTTTTTTCCTAGCCCTCTCACATTTATGAAGCAAGCCCCACTTATTCCCCATTCTTCCT
 561 AGTTTTCTCCTCCCAGGAACTGGGCCAACTCACCTGAGTCACCCTACCTGTGCCTGACCCTACTTCTTTTGCTCTTAGCT
 641 GTCTGCTCAGACAGAACCCCTACATGAAACAGAAACAAAAACACTAAAAATAAAAATGGCCATTTGCTTTTTCACCAGAT
 721 TTGCTAATTTATCCTGAAATTTCAGATTCCCAGAGCAAAATAATTTTAAACAAAGGTTGAGATGTAAAAGGTATTAAATT
 801 GATGTTGCTGGACTGTCATAGAAATTACACCCAAAGAGGTATTTATCTTTACTTTTAAACAGTGAGCCTGAATTTTGTTG
 881 CTGTTTTGATTTGTACTGAAAAATGGTAATTGTTGCTAATCTTCTTATGCAATTTCCTTTTTTGTTATTATTACTTATTT
 961 TTGACAGTGTTGAAAATGTTCAGAAGGTTGCTCTAGATTGAGAGAAGAGACAAACACCTCCCAGGAGACAGTTCAAGAAA
1041 GCTTCAAACTGCATGATTCATGCCAATTAGCAATTGACTGTCACTGTTCCTTGTCACTGGTAGACCAAAATAAAACCAGC
1121 TCTACTGGTCTTGTGGAATTGGGAGCTTGGGAATGGATCCTGGAGGATGCCCAATTAGGGCCTAGCCTTAATCAGGTCCT
1201 CAGAGAATTTCTACCATTTCAGAGAGGCCTTTTGGAATGTGGCCCCTGAACAAGAATTGGAAGCTGCCCTGCCCATGGGA
1281 GCTGGTTAGAAATGCAGAATCCTAGGCTCCACCCCATCCAGTTCATGAGAATCTATATTTAACAAGATCTGCAGGGGGTG
1361 TGTCTGCTCAGTAATTTGAGGACAACCATTCCAGACTGCTTCCAATTTTCTGGAATACATGAAATATAGATCAGTTATAA
1441 GTAGCAGGCCAAGTCAGGCCCTTATTTTCAAGAAACTGAGGAATTTTCTTTGTGTAGCTTTGCTCTTTGGTAGAAAAGGC
1521 TAGGTACACAGCTCTAGACACTGCCACACAGGGTCTGCAAGGTCTTTGGTTCAGCTAAGCTAGGAATGAAATCCTGCTTC
1601 AGTGTATGGAAATAAATGTATCATAGAAATGTAACTTTTGTAAGACAAAGGTTTTCCTCTTCTATTTTGTAAACTCAAAA
1681 TATTTGTACATAGTTATTTATTTATTGGAGATAATCTAGAACACAGGCAAAATCCTTGCTTATGACATCACTTGTACAAA
1761 ATAAACAAATAACAATGTGCTCTCGGGTTGTGTGTCTGTTCACTTTTCCTCCCTCAGTGCCCTCATTTTATGTCATTAAA
1841 TGGGGCTCACAAACCATGCAAATGCTATGAGATGCATGGAGGGCTGCCCTGTACCCCAGCACTTGTGTTGTCTGGTGGTG
1921 GCACCATCTCTGATTTTCAAAGCTTTTTCCAGAGGCTATTATTTTCACTGTAGAATGATTTCATGCTATCTCTGTGTGCA
2001 CAAATATTTATTTTCTTTCTGTAACCATAACAACTTCATATATGAGGACTTGTGTCTCTGTGCTTTTAAATGCATAAATG
2081 CATTATAGGATCATTTGTTGGAATGAATTAAATAAACCCTTCCTGGGGCATCTGGCGAATCCCAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' aacaGGUGAAGAAGGACGGGAc 5'
              |:||||||| :|||:|| 
Target 5' gaccCTACTTCTT-TTGCTCTt 3'
616 - 636 141.00 -17.20
2
miRNA  3' aacaggugaagaagGACGGGAc 5'
                        ||||||| 
Target 5' acaagaattggaagCTGCCCTg 3'
1250 - 1271 140.00 -15.60
3
miRNA  3' aacaggugaagaagGACGGGAc 5'
                        ||||||| 
Target 5' agatgcatggagggCTGCCCTg 3'
1870 - 1891 140.00 -16.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
899343 1 ClinVar
337880 26 ClinVar
899342 27 ClinVar
337879 41 ClinVar
337878 47 ClinVar
337877 87 ClinVar
337876 158 ClinVar
898233 169 ClinVar
898232 230 ClinVar
337875 277 ClinVar
337874 321 ClinVar
337873 325 ClinVar
337872 338 ClinVar
337871 351 ClinVar
337870 497 ClinVar
337869 509 ClinVar
896606 509 ClinVar
896605 511 ClinVar
337868 520 ClinVar
337867 562 ClinVar
337866 663 ClinVar
337865 759 ClinVar
895193 775 ClinVar
337864 793 ClinVar
337863 944 ClinVar
337862 1001 ClinVar
895192 1011 ClinVar
895191 1104 ClinVar
337861 1153 ClinVar
337860 1171 ClinVar
337859 1239 ClinVar
899282 1271 ClinVar
337858 1315 ClinVar
337857 1469 ClinVar
899281 1505 ClinVar
899280 1519 ClinVar
337856 1562 ClinVar
337855 1689 ClinVar
337854 1770 ClinVar
898179 1845 ClinVar
337853 1869 ClinVar
337852 1918 ClinVar
337851 1993 ClinVar
337850 2129 ClinVar
337849 2143 ClinVar
COSN31545885 2 COSMIC
COSN29475367 6 COSMIC
COSN30125179 68 COSMIC
COSN31513389 86 COSMIC
COSN28842986 112 COSMIC
COSN8562898 343 COSMIC
COSN1868290 597 COSMIC
COSN5967516 863 COSMIC
COSN14604358 917 COSMIC
COSN1868289 996 COSMIC
COSN10013174 1011 COSMIC
COSN4779847 1423 COSMIC
COSN1868288 1463 COSMIC
COSN31576974 1498 COSMIC
COSN30545245 1640 COSMIC
COSN31551795 1719 COSMIC
COSN22811475 1763 COSMIC
COSN6686233 1787 COSMIC
COSN26499181 1844 COSMIC
COSN9123823 2031 COSMIC
rs3176123 1001 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752959310 3 dbSNP
rs908965996 4 dbSNP
rs1480512058 6 dbSNP
rs983113093 8 dbSNP
rs765445275 9 dbSNP
rs13306851 10 dbSNP
rs1272741137 14 dbSNP
rs950398067 16 dbSNP
rs1239891261 18 dbSNP
rs1318752174 19 dbSNP
rs566980627 20 dbSNP
rs1390746246 21 dbSNP
rs760823569 23 dbSNP
rs1371532377 24 dbSNP
rs13306852 26 dbSNP
rs530087674 27 dbSNP
rs1384849306 28 dbSNP
rs1380198920 30 dbSNP
rs761189965 31 dbSNP
rs1158736638 35 dbSNP
rs41328344 36 dbSNP
rs1294011663 37 dbSNP
rs1361484502 40 dbSNP
rs1224549889 41 dbSNP
rs377311614 41 dbSNP
rs576345574 41 dbSNP
rs775103380 43 dbSNP
rs1000711528 44 dbSNP
rs551028498 47 dbSNP
rs1254069117 49 dbSNP
rs77670413 51 dbSNP
rs1241667434 55 dbSNP
rs1483071470 59 dbSNP
rs565111682 62 dbSNP
rs1416168703 65 dbSNP
rs1426847961 66 dbSNP
rs1169981839 71 dbSNP
rs141651047 75 dbSNP
rs1240563223 80 dbSNP
rs3176133 87 dbSNP
rs1333200448 89 dbSNP
rs1212101834 90 dbSNP
rs1489120985 94 dbSNP
rs891152417 100 dbSNP
rs1051122432 106 dbSNP
rs1238138975 108 dbSNP
rs572561997 109 dbSNP
rs559059986 110 dbSNP
rs542603082 113 dbSNP
rs376256445 116 dbSNP
rs932869999 117 dbSNP
rs936532361 119 dbSNP
rs1220971617 120 dbSNP
rs1261716210 136 dbSNP
rs1311998412 139 dbSNP
rs773693706 140 dbSNP
rs573584085 147 dbSNP
rs553113676 151 dbSNP
rs3176121 158 dbSNP
rs1193117989 159 dbSNP
rs978827528 164 dbSNP
rs543317002 169 dbSNP
rs1478128924 170 dbSNP
rs1329093535 175 dbSNP
rs879176483 176 dbSNP
rs577889428 184 dbSNP
rs1422911868 185 dbSNP
rs913233354 187 dbSNP
rs1176435126 190 dbSNP
rs557945096 193 dbSNP
rs1360552947 199 dbSNP
rs977123787 201 dbSNP
rs965397457 212 dbSNP
rs1359892782 215 dbSNP
rs1340574058 217 dbSNP
rs1295795158 223 dbSNP
rs1401249862 224 dbSNP
rs1018980192 225 dbSNP
rs1367436349 226 dbSNP
rs1420921091 228 dbSNP
rs985689499 230 dbSNP
rs1380380143 233 dbSNP
rs1315427887 237 dbSNP
rs1038906497 238 dbSNP
rs1216127694 248 dbSNP
rs941549874 252 dbSNP
rs1171595184 253 dbSNP
rs1197309129 261 dbSNP
rs573269226 265 dbSNP
rs952884077 272 dbSNP
rs1427001833 276 dbSNP
rs3176134 277 dbSNP
rs993922566 279 dbSNP
rs983227945 280 dbSNP
rs928937469 281 dbSNP
rs1360723249 282 dbSNP
rs917565191 287 dbSNP
rs1201549615 290 dbSNP
rs991850782 292 dbSNP
rs1490652536 295 dbSNP
rs1320953790 299 dbSNP
rs1263030169 302 dbSNP
rs1215092428 304 dbSNP
rs1371599319 305 dbSNP
rs867446695 307 dbSNP
rs571973180 310 dbSNP
rs1310299546 311 dbSNP
rs1356034611 313 dbSNP
rs56354707 321 dbSNP
rs186669520 325 dbSNP
rs1451031796 326 dbSNP
rs979671052 330 dbSNP
rs1248339902 332 dbSNP
rs1200073283 335 dbSNP
rs1380543482 337 dbSNP
rs536637715 338 dbSNP
rs1161022849 340 dbSNP
rs1437547988 341 dbSNP
rs1276387271 348 dbSNP
rs760402735 350 dbSNP
rs11696919 351 dbSNP
rs1446510538 359 dbSNP
rs1276148762 360 dbSNP
rs1379469590 362 dbSNP
rs891226034 363 dbSNP
rs936563265 363 dbSNP
rs903714374 368 dbSNP
rs375810336 375 dbSNP
rs1401801821 381 dbSNP
rs778866628 382 dbSNP
rs550976991 383 dbSNP
rs900081565 397 dbSNP
rs1291943436 405 dbSNP
rs1456340842 417 dbSNP
rs1197847267 428 dbSNP
rs1238561406 434 dbSNP
rs1038649882 440 dbSNP
rs1184934995 441 dbSNP
rs1164415826 456 dbSNP
rs1236482692 456 dbSNP
rs1472857222 456 dbSNP
rs946142867 457 dbSNP
rs1465551265 467 dbSNP
rs1171914076 479 dbSNP
rs1402867985 480 dbSNP
rs1412369613 482 dbSNP
rs531063182 484 dbSNP
rs1450313568 490 dbSNP
rs571614429 492 dbSNP
rs1403981441 493 dbSNP
rs3176122 497 dbSNP
rs749308300 499 dbSNP
rs777825316 502 dbSNP
rs1341239865 503 dbSNP
rs1198470625 504 dbSNP
rs1423398386 508 dbSNP
rs1189083158 509 dbSNP
rs373979588 509 dbSNP
rs886056545 509 dbSNP
rs182592762 511 dbSNP
rs41282276 520 dbSNP
rs926522508 534 dbSNP
rs1291060451 536 dbSNP
rs952903764 537 dbSNP
rs1187008337 546 dbSNP
rs866975600 548 dbSNP
rs1172300968 555 dbSNP
rs886056544 562 dbSNP
rs1440893832 563 dbSNP
rs1403253740 568 dbSNP
rs1416382219 569 dbSNP
rs542392545 570 dbSNP
rs979343972 576 dbSNP
rs560822407 579 dbSNP
rs967957920 581 dbSNP
rs1278797593 585 dbSNP
rs35315479 594 dbSNP
rs972932784 595 dbSNP
rs961565923 608 dbSNP
rs913710252 623 dbSNP
rs1283320328 625 dbSNP
rs1487688368 626 dbSNP
rs1201248127 633 dbSNP
rs1025168946 634 dbSNP
rs1013323691 635 dbSNP
rs987944275 641 dbSNP
rs1431931085 642 dbSNP
rs894817339 654 dbSNP
rs1033282716 657 dbSNP
rs886056543 663 dbSNP
rs1255942122 666 dbSNP
rs1000740139 670 dbSNP
rs1220367003 676 dbSNP
rs1341096527 680 dbSNP
rs903745167 683 dbSNP
rs945240124 684 dbSNP
rs1445097991 686 dbSNP
rs901657582 687 dbSNP
rs1331451824 691 dbSNP
rs1236156237 692 dbSNP
rs1306669457 695 dbSNP
rs140801073 697 dbSNP
rs1352455949 698 dbSNP
rs542206777 699 dbSNP
rs1334358695 700 dbSNP
rs1041552373 707 dbSNP
rs543416665 717 dbSNP
rs911218193 723 dbSNP
rs1049725543 724 dbSNP
rs1400001110 726 dbSNP
rs1470136584 728 dbSNP
rs955419491 734 dbSNP
rs112351065 735 dbSNP
rs577992030 743 dbSNP
rs73611750 759 dbSNP
rs539785413 775 dbSNP
rs1160597574 777 dbSNP
rs1366761398 783 dbSNP
rs1456373693 784 dbSNP
rs1042580 793 dbSNP
rs1442850992 799 dbSNP
rs1329030691 804 dbSNP
rs1181800324 818 dbSNP
rs555554659 819 dbSNP
rs755156733 828 dbSNP
rs536323252 834 dbSNP
rs1319433697 846 dbSNP
rs1243384747 847 dbSNP
rs961874360 862 dbSNP
rs918062882 864 dbSNP
rs567754337 865 dbSNP
rs1237946685 868 dbSNP
rs1236102321 877 dbSNP
rs1200375765 894 dbSNP
rs1458412820 904 dbSNP
rs747456408 904 dbSNP
rs1307874220 906 dbSNP
rs1423351265 909 dbSNP
rs1288974078 912 dbSNP
rs1165487161 914 dbSNP
rs1369046420 924 dbSNP
rs1226568935 927 dbSNP
rs557031106 944 dbSNP
rs759004623 944 dbSNP
rs1399251792 947 dbSNP
rs1447191002 953 dbSNP
rs887369013 958 dbSNP
rs992335182 962 dbSNP
rs1394957806 963 dbSNP
rs1312786744 966 dbSNP
rs1337662670 973 dbSNP
rs959113314 976 dbSNP
rs1047226606 982 dbSNP
rs1319060242 983 dbSNP
rs1207016389 986 dbSNP
rs1254488680 993 dbSNP
rs1483041132 999 dbSNP
rs3176123 1001 dbSNP
rs896219797 1006 dbSNP
rs1445547589 1007 dbSNP
rs1476175587 1008 dbSNP
rs534762196 1011 dbSNP
rs1329705133 1017 dbSNP
rs1410332146 1021 dbSNP
rs766785219 1022 dbSNP
rs1449381279 1024 dbSNP
rs150954754 1041 dbSNP
rs1465226644 1042 dbSNP
rs1302960517 1044 dbSNP
rs1356787968 1053 dbSNP
rs1397532190 1054 dbSNP
rs1278153412 1055 dbSNP
rs1164639585 1056 dbSNP
rs1216702583 1060 dbSNP
rs551683637 1063 dbSNP
rs937658734 1070 dbSNP
rs1404119253 1078 dbSNP
rs1311870669 1079 dbSNP
rs1211061708 1080 dbSNP
rs1282681340 1086 dbSNP
rs867134839 1088 dbSNP
rs867266986 1102 dbSNP
rs926288174 1104 dbSNP
rs1043388573 1115 dbSNP
rs1416023125 1117 dbSNP
rs1262408597 1124 dbSNP
rs946604316 1139 dbSNP
rs901684283 1141 dbSNP
rs1439313810 1145 dbSNP
rs886056542 1153 dbSNP
rs1422759973 1166 dbSNP
rs528644986 1167 dbSNP
rs763298023 1170 dbSNP
rs143450327 1171 dbSNP
rs1417325881 1174 dbSNP
rs1180749284 1179 dbSNP
rs955269474 1180 dbSNP
rs1245936212 1182 dbSNP
rs922666405 1183 dbSNP
rs1273496039 1185 dbSNP
rs1367375687 1201 dbSNP
rs1220141175 1205 dbSNP
rs1305908365 1207 dbSNP
rs1351714236 1211 dbSNP
rs975548390 1213 dbSNP
rs1219257816 1215 dbSNP
rs1286814260 1226 dbSNP
rs1447550927 1227 dbSNP
rs964494422 1228 dbSNP
rs549574979 1239 dbSNP
rs765710429 1241 dbSNP
rs1488052802 1244 dbSNP
rs1193953903 1245 dbSNP
rs1396522025 1246 dbSNP
rs1437419244 1248 dbSNP
rs1157571013 1266 dbSNP
rs951567761 1267 dbSNP
rs528933728 1269 dbSNP
rs1401892041 1270 dbSNP
rs563439109 1271 dbSNP
rs1350873408 1272 dbSNP
rs543047467 1276 dbSNP
rs1025939321 1284 dbSNP
rs1014421111 1293 dbSNP
rs551790737 1302 dbSNP
rs1224020499 1307 dbSNP
rs1328334792 1309 dbSNP
rs1374444074 1312 dbSNP
rs886056541 1315 dbSNP
rs1434899687 1322 dbSNP
rs1297262162 1324 dbSNP
rs1352186028 1325 dbSNP
rs1352960819 1326 dbSNP
rs931326574 1333 dbSNP
rs1303822542 1346 dbSNP
rs1056387650 1351 dbSNP
rs919913089 1354 dbSNP
rs1001935035 1358 dbSNP
rs1378580083 1359 dbSNP
rs1456207264 1363 dbSNP
rs6082989 1371 dbSNP
rs1037702699 1379 dbSNP
rs1177652665 1384 dbSNP
rs1233060726 1391 dbSNP
rs1470883279 1393 dbSNP
rs1413783119 1397 dbSNP
rs1160631559 1399 dbSNP
rs1419953198 1411 dbSNP
rs762331942 1416 dbSNP
rs1424173923 1421 dbSNP
rs375737788 1427 dbSNP
rs1043336602 1429 dbSNP
rs918081201 1430 dbSNP
rs1478963286 1442 dbSNP
rs946425875 1443 dbSNP
rs1283659859 1447 dbSNP
rs1354815966 1458 dbSNP
rs771554213 1459 dbSNP
rs3176124 1469 dbSNP
rs774143808 1479 dbSNP
rs1216035617 1490 dbSNP
rs1311291093 1492 dbSNP
rs1197708431 1496 dbSNP
rs879893799 1497 dbSNP
rs1439185320 1505 dbSNP
rs926413643 1508 dbSNP
rs1236348408 1522 dbSNP
rs933801061 1531 dbSNP
rs1190721932 1537 dbSNP
rs1422056834 1540 dbSNP
rs564360014 1541 dbSNP
rs1217892820 1561 dbSNP
rs183647515 1562 dbSNP
rs1284443059 1563 dbSNP
rs1412977291 1570 dbSNP
rs1333649432 1572 dbSNP
rs942764433 1588 dbSNP
rs1416658735 1594 dbSNP
rs1295060582 1601 dbSNP
rs1338264578 1605 dbSNP
rs865898843 1613 dbSNP
rs572395082 1624 dbSNP
rs561688432 1625 dbSNP
rs951392319 1626 dbSNP
rs1300161832 1630 dbSNP
rs371533901 1640 dbSNP
rs1009914342 1649 dbSNP
rs1277411710 1651 dbSNP
rs1025886804 1655 dbSNP
rs1485729048 1656 dbSNP
rs1212319549 1657 dbSNP
rs965957411 1659 dbSNP
rs1477772580 1667 dbSNP
rs1194424139 1674 dbSNP
rs1019273242 1676 dbSNP
rs886056540 1689 dbSNP
rs1172244728 1690 dbSNP
rs1395850409 1696 dbSNP
rs1454502353 1697 dbSNP
rs1296408499 1704 dbSNP
rs542015016 1710 dbSNP
rs1174244191 1711 dbSNP
rs1318777118 1718 dbSNP
rs1415889492 1719 dbSNP
rs1327999917 1722 dbSNP
rs960583361 1734 dbSNP
rs551264425 1735 dbSNP
rs529417428 1736 dbSNP
rs1002114154 1742 dbSNP
rs1235929828 1750 dbSNP
rs1049868061 1751 dbSNP
rs1283257478 1752 dbSNP
rs3176135 1763 dbSNP
rs113252822 1770 dbSNP
rs1022034799 1773 dbSNP
rs1476826820 1776 dbSNP
rs3179769 1780 dbSNP
rs1010516979 1784 dbSNP
rs892155466 1785 dbSNP
rs1186665614 1787 dbSNP
rs1198531958 1796 dbSNP
rs1482716229 1797 dbSNP
rs1455745723 1803 dbSNP
rs1253825622 1817 dbSNP
rs557474793 1820 dbSNP
rs1036995984 1822 dbSNP
rs940273835 1824 dbSNP
rs191096584 1830 dbSNP
rs1386961826 1832 dbSNP
rs1384872178 1834 dbSNP
rs1324955335 1835 dbSNP
rs1371363824 1840 dbSNP
rs1442609202 1843 dbSNP
rs867940213 1845 dbSNP
rs1057114928 1855 dbSNP
rs886056539 1869 dbSNP
rs1315844977 1875 dbSNP
rs1239057300 1877 dbSNP
rs938204165 1883 dbSNP
rs1240953527 1885 dbSNP
rs926777959 1887 dbSNP
rs865792781 1894 dbSNP
rs1253989874 1904 dbSNP
rs570890550 1910 dbSNP
rs1470035051 1914 dbSNP
rs1177022952 1915 dbSNP
rs748047270 1917 dbSNP
rs1962 1918 dbSNP
rs1419749007 1924 dbSNP
rs913568253 1935 dbSNP
rs1339185691 1940 dbSNP
rs1365520994 1943 dbSNP
rs1297802180 1955 dbSNP
rs1163998888 1959 dbSNP
rs1394916735 1966 dbSNP
rs918564297 1976 dbSNP
rs1328879180 1985 dbSNP
rs534957785 1991 dbSNP
rs1301273728 1992 dbSNP
rs3176136 1993 dbSNP
rs1406510175 1999 dbSNP
rs1018889425 2001 dbSNP
rs1233190484 2004 dbSNP
rs1274304959 2016 dbSNP
rs986440930 2021 dbSNP
rs534184183 2023 dbSNP
rs1197066346 2026 dbSNP
rs1035056258 2029 dbSNP
rs1481073324 2031 dbSNP
rs1027466935 2044 dbSNP
rs6113910 2046 dbSNP
rs980287311 2079 dbSNP
rs1254131067 2080 dbSNP
rs1171075392 2088 dbSNP
rs968888031 2089 dbSNP
rs1253491212 2090 dbSNP
rs1187162861 2091 dbSNP
rs1418404847 2093 dbSNP
rs1168258849 2101 dbSNP
rs1353630904 2106 dbSNP
rs1462153039 2110 dbSNP
rs1021982619 2112 dbSNP
rs1299435196 2116 dbSNP
rs1399468963 2117 dbSNP
rs898547220 2120 dbSNP
rs372816835 2129 dbSNP
rs1004255849 2131 dbSNP
rs536093215 2136 dbSNP
rs892229014 2137 dbSNP
rs3176126 2143 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903832
Method / RBP HITS-CLIP / AGO
Cell line / Condition Human neurons / 124TD_shELAVL3_b
Location of target site NM_000361 | 3UTR | UGGAAGCUGCCCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161238
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000377103.2 | 3UTR | ACAAGAAUUGGAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000377103.2 | 3UTR | ACAAGAAUUGGAAGCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000377103.2 | 3UTR | ACAAGAAUUGGAAGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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