pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ACTN2   
Synonyms CMD1AA, CMH23
Description actinin alpha 2
Transcript NM_001103   
Expression
Putative miRNA Targets on ACTN2
3'UTR of ACTN2
(miRNA target sites are highlighted)
>ACTN2|NM_001103|3'UTR
   1 TGCTGAGCTTCTGTAATCACTCATCCCATCAGAATGCAATAAAAGCGGAAGTCACAGTTTGTTTCCTGGAAACTTTGACA
  81 AGCTTTATTAAGTTGAGAGAGAGAGAGGGGAAAAAAAAAAGCCTTTCGTAGTTCAGTAATTGCCAGCAATATAACACGGC
 161 TAAAATGAAGTTTTTACAGTATATGACATAGTGCGCTTCATAAATAGGTTTATTTCTGAGTTTTTAGCAAAATGTAATGA
 241 AATATCAGGTTGATTTCTTTGATTAAACAGAACAAATTACTTGAGTAATAGGAAATTAGGAGGATCTAGGGACAGAAGGA
 321 AAGTGAAAAATGTGAAAATACAAAATACCCAAGATTTAAGACCGGGGGGAAAAAACCACAAATTGGTAAATAAAGGTTTG
 401 CTATTTGTAAAAAATTTCATTTATCTCTAATATGCTTATGTGATTGCCCCTAGGGGAGTATATTTGGGATTCTAATGTTT
 481 TATTTTCATGCTTATCCAAAGATTACTATTGTATCTTCAAATGAATTTAATATTGTGAGATGGAACTGCCGGGGATTAAA
 561 AAGACTACCCAAAAGATTTTTGGCACTTACAATTTTTAAAATAGTTTATGTCATCTCTTCATTATTTAGGGCTGGATGGT
 641 CAACTCAGTCAGTGATTTTTTGATGCTTCTCTTATCCTCCAGAATAGAGACCTAAGGACACGTGGAAGTCAGTTTAATTG
 721 CCAGAGAGAAGGATGCAATCACTAGGTAAAATGAGGTTTTTAGGATTATTTATTGATTCCAGGTTCCCATGCTTTTTGTT
 801 AGAGCTTATTAGTACAGGTTCTCAAGAGATGACCACATAAAAGTGCTCTGTTTATAAATAAGCAGGTTTCTGTAGTACTG
 881 ACTGGTTCATCACAAGGCAAGTCAGAAACCAGTATCCTTCTAGCTCTCCAGTCAGGACTTCCTTATGCCTCTAGTTTTAT
 961 GACCGGTTAAGGAGAAGCCAGAGTTAGAGTAGGAGAGGACTAATTCTCAGCAGCAGTGGAGGTGAGTTCTTTCTTTTGCG
1041 GAAGCTTTACATATGTTTTGTGTAGTAGGAATAACTAGATATTTTAGCTAGTGTGCGGTGTGTGTTCACCCCTGGGATTG
1121 GACAGTGTATCCTAACAAGTCCCATGTCTGGTTCTGTGTCTAAAGGCCTGCTCCATGACACAGGATGCTACATGCACTCC
1201 TGCTAGCACATCTTGATCTGTTGAATGTTCATTCTTTCTTTTTGCTCATACTGCTGTAGGCTATAATTCCCCCCTGTTTT
1281 TCCATCTTGTTGACAGCTTGTAGAGAATAAAGCAGGAATTCTTTTTATATCTGAGTCCTTAATGATCAGGAAATGGATTA
1361 CAAACAAACAAAAACAGTTGCAAACAGCAATTAAAGCATTACTAGAGAAGCAGTAACATGTCTGTTACCTACAGTCTGTT
1441 TGCTCAGATTTTTATAGATTTCCACCAACAGCTGGAAATGTAATATTTCCATTCCAAGCTGTCTGACAGCTTGACTCTTC
1521 TTCCTACACTGGGCCATTTAGAACCTTCAACCTTTATGAATTTCACTTAATTTGCTTCATTATTAAGTAATTGGTAGTTT
1601 CCAGATTCCTGAAATATTTGAATCCTTGAGTTTAATGCCAAACACTTTTGGGGTGGTTTAGATGAACTCTGACTCTATTT
1681 TATTTCAAGTAGGTGCTATATCCCGGCCATAAACCCCTATAGAAAAGCCAGAAAGTTGTGCTTCCTTTGAGGCTATTAGG
1761 GGGCTCTGTGGTGTTTTAGGATGGGTGTGGGTAACTCATCTACCTAAACTTTTAATTTCTTTACAACATTCAGCAAGAGA
1841 GGGGGTCAGTAGTCTCTATCTGCTAATAAATGAAGAAAGGAAGTAAACTCTGAAAAATAATAAACATGTTTATACTCTCA
1921 TTTTAGGTATTATTTTTATTTCTGAAGCTGGATGCTCAAAAATTAAAACGTTTATAAGTTTCTAAATTAAACTTAATTTA
2001 TAAAAGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauaccCACCCUGUCUCUCCc 5'
                | | || ||||||| 
Target 5' taagttGAGAGAGAGAGAGGg 3'
89 - 109 151.00 -17.70
2
miRNA  3' gauacccacccugUCUCUCCc 5'
                       ||||||| 
Target 5' acaacattcagcaAGAGAGGg 3'
1823 - 1843 140.00 -14.20
3
miRNA  3' gauacccaccCUGUCUCUCcc 5'
                    | |||||||  
Target 5' cagtttaattGCCAGAGAGaa 3'
710 - 730 127.00 -8.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
430146 4 ClinVar
915740 11 ClinVar
296511 44 ClinVar
875346 47 ClinVar
875400 107 ClinVar
296512 112 ClinVar
875401 129 ClinVar
296513 158 ClinVar
296514 287 ClinVar
296515 397 ClinVar
296516 424 ClinVar
296517 448 ClinVar
876432 489 ClinVar
296518 527 ClinVar
874479 552 ClinVar
874480 642 ClinVar
296519 701 ClinVar
296520 725 ClinVar
296521 749 ClinVar
874530 849 ClinVar
296522 887 ClinVar
874531 900 ClinVar
874532 912 ClinVar
296523 955 ClinVar
874533 980 ClinVar
874534 1002 ClinVar
296524 1041 ClinVar
296525 1088 ClinVar
296526 1098 ClinVar
296527 1110 ClinVar
875457 1117 ClinVar
296528 1254 ClinVar
875458 1260 ClinVar
296529 1274 ClinVar
296530 1274 ClinVar
296531 1289 ClinVar
296532 1302 ClinVar
876475 1646 ClinVar
296533 1652 ClinVar
876476 1704 ClinVar
876477 1705 ClinVar
876478 1970 ClinVar
COSN31572680 4 COSMIC
COSN26964979 17 COSMIC
COSN30114739 20 COSMIC
COSN31491580 20 COSMIC
COSN30486061 28 COSMIC
COSN30179928 31 COSMIC
COSN30485881 32 COSMIC
COSN30177662 48 COSMIC
COSN31492228 63 COSMIC
COSN31542331 101 COSMIC
COSN15667476 107 COSMIC
COSN20124440 111 COSMIC
COSN7209431 113 COSMIC
COSN1436918 121 COSMIC
COSN27728048 363 COSMIC
COSN18788576 369 COSMIC
COSN6448814 701 COSMIC
COSN29358501 763 COSMIC
COSN6028034 867 COSMIC
COSN8449574 1032 COSMIC
COSN31778091 1118 COSMIC
COSN22882632 1186 COSMIC
COSN16357809 1873 COSMIC
COSN21072158 1931 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1131691800 4 dbSNP
rs1302474829 5 dbSNP
rs750971577 9 dbSNP
rs991306355 11 dbSNP
rs754961446 14 dbSNP
rs781054133 17 dbSNP
rs1396007060 21 dbSNP
rs748074241 24 dbSNP
rs1436519267 29 dbSNP
rs755943513 35 dbSNP
rs1382142676 39 dbSNP
rs758068136 44 dbSNP
rs1486812161 45 dbSNP
rs74146254 47 dbSNP
rs191235353 48 dbSNP
rs1172205052 62 dbSNP
rs1378518999 67 dbSNP
rs1192757257 69 dbSNP
rs1288440420 74 dbSNP
rs534518340 74 dbSNP
rs1002179172 86 dbSNP
rs1215469300 89 dbSNP
rs897814687 94 dbSNP
rs148159045 95 dbSNP
rs1488600830 95 dbSNP
rs1464244007 106 dbSNP
rs1032334316 107 dbSNP
rs199921605 107 dbSNP
rs1275152992 111 dbSNP
rs370482371 111 dbSNP
rs879561573 111 dbSNP
rs958260983 111 dbSNP
rs1051251 112 dbSNP
rs1049545925 113 dbSNP
rs954909709 117 dbSNP
rs577593687 123 dbSNP
rs369096287 124 dbSNP
rs544318883 128 dbSNP
rs142016713 129 dbSNP
rs1162813117 132 dbSNP
rs1194608841 135 dbSNP
rs963763581 144 dbSNP
rs1255418990 146 dbSNP
rs184479165 158 dbSNP
rs1444061101 159 dbSNP
rs751301846 178 dbSNP
rs1279135563 180 dbSNP
rs1463525132 186 dbSNP
rs1194989070 188 dbSNP
rs1259623035 189 dbSNP
rs1166251830 195 dbSNP
rs919624008 201 dbSNP
rs1290904579 223 dbSNP
rs902057892 229 dbSNP
rs754910214 234 dbSNP
rs1328654653 243 dbSNP
rs757824001 249 dbSNP
rs763185284 254 dbSNP
rs1433379966 264 dbSNP
rs1399025051 269 dbSNP
rs1320626128 270 dbSNP
rs1327837946 271 dbSNP
rs542271531 272 dbSNP
rs867559064 274 dbSNP
rs190536248 287 dbSNP
rs1283151084 314 dbSNP
rs1029339523 327 dbSNP
rs1167174966 333 dbSNP
rs1473763482 336 dbSNP
rs967119702 341 dbSNP
rs1376315266 346 dbSNP
rs1237951060 359 dbSNP
rs752841623 364 dbSNP
rs949224244 364 dbSNP
rs1033102371 365 dbSNP
rs957304380 368 dbSNP
rs528243724 369 dbSNP
rs1229509736 370 dbSNP
rs767612340 370 dbSNP
rs905299403 371 dbSNP
rs528726906 372 dbSNP
rs1337906172 373 dbSNP
rs1328325458 374 dbSNP
rs547172482 377 dbSNP
rs1206602757 381 dbSNP
rs181994486 397 dbSNP
rs1328050346 399 dbSNP
rs1447860924 414 dbSNP
rs1187080790 415 dbSNP
rs1235849172 419 dbSNP
rs114880747 424 dbSNP
rs1009951324 433 dbSNP
rs1468474258 435 dbSNP
rs1188689920 439 dbSNP
rs532427877 440 dbSNP
rs1179003322 443 dbSNP
rs1467785930 446 dbSNP
rs1250788780 447 dbSNP
rs374820348 447 dbSNP
rs1051253 448 dbSNP
rs955108539 460 dbSNP
rs1203961904 462 dbSNP
rs1356448828 463 dbSNP
rs1160718590 465 dbSNP
rs1386113989 467 dbSNP
rs919315850 477 dbSNP
rs1400980597 487 dbSNP
rs1017812616 489 dbSNP
rs929376504 495 dbSNP
rs1316300149 509 dbSNP
rs1398935331 511 dbSNP
rs568793519 514 dbSNP
rs1159141826 521 dbSNP
rs1453602164 522 dbSNP
rs1803032 527 dbSNP
rs746815566 534 dbSNP
rs1039723685 549 dbSNP
rs548278039 551 dbSNP
rs566548706 552 dbSNP
rs35814631 555 dbSNP
rs1287402887 557 dbSNP
rs982814945 568 dbSNP
rs185760073 580 dbSNP
rs1281080054 587 dbSNP
rs997617533 591 dbSNP
rs561037796 603 dbSNP
rs1281122157 607 dbSNP
rs1268534809 612 dbSNP
rs1042536651 616 dbSNP
rs189835259 632 dbSNP
rs1341161443 634 dbSNP
rs1298748522 642 dbSNP
rs1046281008 644 dbSNP
rs1357282068 654 dbSNP
rs1199628816 666 dbSNP
rs902909574 670 dbSNP
rs776566555 674 dbSNP
rs1276800860 680 dbSNP
rs999047628 684 dbSNP
rs1486744091 685 dbSNP
rs12733179 701 dbSNP
rs146311878 703 dbSNP
rs1263202125 716 dbSNP
rs1187863265 720 dbSNP
rs7532533 725 dbSNP
rs1239634358 728 dbSNP
rs1211230111 729 dbSNP
rs1184572976 734 dbSNP
rs1307243868 736 dbSNP
rs1053884282 737 dbSNP
rs893845383 738 dbSNP
rs7522310 749 dbSNP
rs1042754223 753 dbSNP
rs1414154557 754 dbSNP
rs1022858669 757 dbSNP
rs971319539 758 dbSNP
rs981231448 762 dbSNP
rs1395505354 765 dbSNP
rs919100222 768 dbSNP
rs1353655609 776 dbSNP
rs866167568 780 dbSNP
rs985319125 793 dbSNP
rs1369381529 798 dbSNP
rs1017864965 801 dbSNP
rs541983310 819 dbSNP
rs909195774 824 dbSNP
rs553877876 829 dbSNP
rs1258920062 837 dbSNP
rs1182904260 840 dbSNP
rs1480520531 852 dbSNP
rs1231470147 857 dbSNP
rs1330853970 859 dbSNP
rs769258299 863 dbSNP
rs943337180 866 dbSNP
rs1232278113 872 dbSNP
rs1300901433 875 dbSNP
rs1458374093 885 dbSNP
rs886046208 887 dbSNP
rs964907928 890 dbSNP
rs1323539356 895 dbSNP
rs1274074530 899 dbSNP
rs1314796145 900 dbSNP
rs1482096485 908 dbSNP
rs772767995 910 dbSNP
rs762530976 912 dbSNP
rs1228753601 917 dbSNP
rs1372347115 918 dbSNP
rs1329033507 921 dbSNP
rs994970465 930 dbSNP
rs1400537138 937 dbSNP
rs1324762278 947 dbSNP
rs1455955342 949 dbSNP
rs2153203 955 dbSNP
rs540078811 965 dbSNP
rs751383598 966 dbSNP
rs1197201908 971 dbSNP
rs181615071 980 dbSNP
rs970365459 989 dbSNP
rs1455347218 993 dbSNP
rs532312857 1000 dbSNP
rs902731297 1002 dbSNP
rs937850498 1018 dbSNP
rs185695273 1019 dbSNP
rs1460049109 1039 dbSNP
rs190412319 1041 dbSNP
rs945483472 1047 dbSNP
rs1306866183 1052 dbSNP
rs1042454037 1057 dbSNP
rs1054644425 1061 dbSNP
rs1392212694 1062 dbSNP
rs1384651284 1069 dbSNP
rs944679368 1073 dbSNP
rs11801672 1088 dbSNP
rs1453738420 1091 dbSNP
rs1359154699 1092 dbSNP
rs900715288 1093 dbSNP
rs1012971923 1097 dbSNP
rs886046209 1098 dbSNP
rs1394796178 1099 dbSNP
rs759273956 1110 dbSNP
rs749806314 1113 dbSNP
rs1268212545 1115 dbSNP
rs548189072 1117 dbSNP
rs1484913323 1118 dbSNP
rs907083152 1119 dbSNP
rs1218634309 1124 dbSNP
rs1002825020 1125 dbSNP
rs1354160356 1127 dbSNP
rs1279338073 1128 dbSNP
rs1028208180 1136 dbSNP
rs886596301 1146 dbSNP
rs1301411068 1152 dbSNP
rs1381191009 1162 dbSNP
rs1229722139 1165 dbSNP
rs1337704150 1167 dbSNP
rs1300601647 1177 dbSNP
rs1026149530 1182 dbSNP
rs1171168141 1190 dbSNP
rs1356342788 1191 dbSNP
rs950630667 1193 dbSNP
rs1255332361 1194 dbSNP
rs984878604 1196 dbSNP
rs1016739224 1198 dbSNP
rs1476891526 1205 dbSNP
rs1265348881 1206 dbSNP
rs865894215 1212 dbSNP
rs1488569141 1217 dbSNP
rs1255273747 1221 dbSNP
rs1198484902 1230 dbSNP
rs1015289164 1232 dbSNP
rs1256247919 1234 dbSNP
rs1226164491 1236 dbSNP
rs1188272893 1238 dbSNP
rs964827422 1239 dbSNP
rs975115829 1250 dbSNP
rs886046210 1254 dbSNP
rs1279536562 1257 dbSNP
rs923309936 1260 dbSNP
rs1426301969 1264 dbSNP
rs1398182745 1267 dbSNP
rs560327300 1271 dbSNP
rs933574166 1272 dbSNP
rs771809993 1274 dbSNP
rs886046211 1274 dbSNP
rs751155398 1278 dbSNP
rs553149210 1284 dbSNP
rs924100761 1285 dbSNP
rs886046212 1289 dbSNP
rs1033576710 1294 dbSNP
rs1367851460 1301 dbSNP
rs886046213 1302 dbSNP
rs12563377 1304 dbSNP
rs1443940237 1306 dbSNP
rs527375632 1322 dbSNP
rs1457387830 1323 dbSNP
rs1162660853 1330 dbSNP
rs892836235 1331 dbSNP
rs1337535291 1333 dbSNP
rs948503107 1344 dbSNP
rs1319577364 1349 dbSNP
rs1354986779 1360 dbSNP
rs1282961386 1365 dbSNP
rs1247541197 1375 dbSNP
rs767275730 1380 dbSNP
rs531540672 1381 dbSNP
rs1328591254 1385 dbSNP
rs756447766 1398 dbSNP
rs945224525 1413 dbSNP
rs1444906803 1420 dbSNP
rs978613620 1427 dbSNP
rs1384129382 1433 dbSNP
rs1461009078 1434 dbSNP
rs752614074 1435 dbSNP
rs1161393837 1437 dbSNP
rs1296456202 1439 dbSNP
rs911943689 1443 dbSNP
rs1226966979 1447 dbSNP
rs1473733973 1451 dbSNP
rs139476464 1452 dbSNP
rs1177748940 1456 dbSNP
rs1437474093 1464 dbSNP
rs1026263599 1469 dbSNP
rs1231489946 1479 dbSNP
rs886377121 1486 dbSNP
rs1006429508 1495 dbSNP
rs1016107622 1496 dbSNP
rs1336028648 1502 dbSNP
rs1239650211 1517 dbSNP
rs965149351 1522 dbSNP
rs1450546650 1523 dbSNP
rs1287131972 1525 dbSNP
rs1212215069 1527 dbSNP
rs142223565 1536 dbSNP
rs1030273563 1537 dbSNP
rs1238471520 1551 dbSNP
rs1379517041 1565 dbSNP
rs1049298660 1566 dbSNP
rs756072732 1567 dbSNP
rs1325593429 1571 dbSNP
rs1407058058 1575 dbSNP
rs1391319753 1580 dbSNP
rs180804353 1597 dbSNP
rs1187884537 1598 dbSNP
rs568637890 1598 dbSNP
rs886641245 1603 dbSNP
rs535492106 1623 dbSNP
rs1261864298 1637 dbSNP
rs1477487044 1645 dbSNP
rs577833572 1646 dbSNP
rs764609669 1652 dbSNP
rs978078534 1657 dbSNP
rs1285957630 1665 dbSNP
rs1215015113 1667 dbSNP
rs1185092003 1673 dbSNP
rs1287184716 1674 dbSNP
rs553741232 1704 dbSNP
rs924162671 1705 dbSNP
rs1003177263 1706 dbSNP
rs936940479 1715 dbSNP
rs1276724575 1717 dbSNP
rs990018495 1718 dbSNP
rs1339866658 1734 dbSNP
rs1158232422 1739 dbSNP
rs1033336246 1741 dbSNP
rs1362290164 1754 dbSNP
rs1159006445 1758 dbSNP
rs1413595653 1762 dbSNP
rs916786405 1765 dbSNP
rs1422660305 1767 dbSNP
rs959054607 1777 dbSNP
rs1478078605 1791 dbSNP
rs1011277139 1802 dbSNP
rs1192207318 1810 dbSNP
rs1489549052 1820 dbSNP
rs948471554 1823 dbSNP
rs1209813121 1840 dbSNP
rs1289702996 1844 dbSNP
rs1267833456 1845 dbSNP
rs1219972606 1846 dbSNP
rs1401707854 1850 dbSNP
rs1276373612 1855 dbSNP
rs1216776654 1857 dbSNP
rs572253689 1859 dbSNP
rs1295134227 1861 dbSNP
rs10159350 1864 dbSNP
rs539505686 1866 dbSNP
rs966955174 1872 dbSNP
rs1335787466 1876 dbSNP
rs1414674902 1882 dbSNP
rs1422363590 1883 dbSNP
rs928270705 1893 dbSNP
rs938298756 1908 dbSNP
rs1167890716 1918 dbSNP
rs186068084 1920 dbSNP
rs139516014 1928 dbSNP
rs1181734349 1930 dbSNP
rs886320797 1939 dbSNP
rs1239507106 1943 dbSNP
rs151212105 1960 dbSNP
rs753897286 1970 dbSNP
rs1256284465 1971 dbSNP
rs1037938837 1973 dbSNP
rs536498091 1985 dbSNP
rs1260964961 1990 dbSNP
rs974812280 1993 dbSNP
rs1296227028 2005 dbSNP
rs1227609439 2011 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000366578.4 | 3UTR | UUGAGAGAGAGAGAGGGGAAAAAAAAAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000366578.4 | 3UTR | GAGGGGAAAAAAAAAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000366578.4 | 3UTR | GAGAGGGGAAAAAAAAAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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