pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol ZNF324B   
Synonyms -
Description zinc finger protein 324B
Transcript NM_207395   
Expression
Putative miRNA Targets on ZNF324B
3'UTR of ZNF324B
(miRNA target sites are highlighted)
>ZNF324B|NM_207395|3'UTR
   1 GGTCACAGGTCGCAGCCCAACCCTTTCTTGGCCTTCTGTGAATCCCTTCCACAGCTAAAGGGTCCGAGTGCTCTTCAGAT
  81 CCACGATGGGGAAAAGCTCTGTGCCTGAGAGTCAGGGACGAGGGAGACCCTTTGGCTGTGGTTCCATTTGCAGGTGGGGA
 161 CAGGATTTGCCAGTTTAGTCATAGCTCACACCTCCATCCTCAAAGAGGTAACACTGCAGAAACATCAGAGGGAGGACATG
 241 TCAGCTGGAACTCTGGTGGGGCTGAGGCTGTAGTTGGGGCCATAGGACGCCGACAAAGGCAGCGCTGCATGGTGGTGCTA
 321 CTTCATGTGTTATGAGAGTGGATGCTGAGGTGAGGGGGATGCGGACATGGGGTAGGATGACCTAGAGAAACTTATGATGT
 401 CTGCACACAAACTGGCCGCTAGACGGACGCTGAGGACATTTTCCCCCTGAGGCCTCTATTCAAGGCTTCCTGGGGGCCAT
 481 CTCAGCAAACAGGAGACTACAGGGGACTGGGGATCAGGGTGTGGCCTGTGAGTGTCAGCCTCCTCCTCGGAAAAAGAAAA
 561 GCTTTGGGTCAACTCAGCATCATGTTTGCAGATGCTGACAGACGGGATCCTAATGAGAGTCAATGTGTGCTCACTGCCAG
 641 CTCCTGGGCTGTGCTCTGGTCAGCCAGGTGTGAGGGCCTGGCCTGGGGTCACACAGCTGACTCAGGAGAGGAATGCCCAT
 721 GGTTCTCAGCATTGGAAGGACAAACCTAGGATGATGGCTTTCCAGTGGCACTCGTTCAGGTTTTCGTCCAAGTCTCAGCT
 801 TGGCCAAGGCCTGTCGCTCACTCATTTACAAAAGTCGATGTGAGGAGGAGCCTTTACACCTGTGGAGACAGTGATAGCTT
 881 TGGAGCAGATAAGGTGGAGCTGCTCATTTTTGCTGGATTTGGTGGCCGATCCCCGCCCCCACCCCCACCCCCTCCATCTC
 961 ACCTTTCCCTTGTTATGCCTCCTCAATTGGAGGCTGGACAGAGAGCTGAATAGGAAGGACTTGCCATTACCTAAGGCCAT
1041 GTGTGACAGCCTCCTGAGGACCTCCCCAACCCAGTGTGATGGGCCTGCATGGCAGAGACAAAAGGGTAGACTGGGGGTCA
1121 TTTGCTTCCTGTGGCCTTAAGCCTACTAGGCCCCATCCTTACCTGAGACCTCACCTCCAAGAAATTAATGGTCTTTTCAA
1201 TGGAGAAAAAAAAAGACTAGTATTTGCAACTTCAAATAGATGTAGTTTCCTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agUGUCAACGGUCGACUCUAau 5'
            | ||| | : ||||||:|  
Target 5' tgAGAGTGGAT-GCTGAGGTga 3'
333 - 353 123.00 -12.10
2
miRNA  3' agUGUCAACG-GUCGACUCUAAu 5'
            | || | : :: |||||| | 
Target 5' gaAAAGCTCTGTGCCTGAGAGTc 3'
91 - 113 116.00 -8.32
3
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            ||:|   ||   ||||| | 
Target 5' agACGGGATCCTAATGAGAGTc 3'
600 - 621 116.00 -10.72
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN20063460 12 COSMIC
COSN28870978 13 COSMIC
COSN31508348 16 COSMIC
COSN30177092 110 COSMIC
COSN8977239 568 COSMIC
COSN20691229 652 COSMIC
COSN28640327 709 COSMIC
COSN31521167 786 COSMIC
COSN31533107 817 COSMIC
COSN28741870 930 COSMIC
COSN19534288 1054 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748925863 5 dbSNP
rs192112354 8 dbSNP
rs1225688772 10 dbSNP
rs780975950 12 dbSNP
rs1261521330 13 dbSNP
rs975670665 15 dbSNP
rs1323059918 21 dbSNP
rs185016991 22 dbSNP
rs747547426 23 dbSNP
rs56662577 34 dbSNP
rs1160515061 38 dbSNP
rs1448719476 43 dbSNP
rs1190959124 44 dbSNP
rs1262305327 45 dbSNP
rs773580244 46 dbSNP
rs571133942 50 dbSNP
rs533682856 62 dbSNP
rs113008143 63 dbSNP
rs1217097000 72 dbSNP
rs1246910152 73 dbSNP
rs1051689833 81 dbSNP
rs370263228 83 dbSNP
rs1197778682 86 dbSNP
rs892607428 90 dbSNP
rs1466724169 107 dbSNP
rs912866087 112 dbSNP
rs968451818 115 dbSNP
rs1328322294 120 dbSNP
rs190706397 121 dbSNP
rs945471811 124 dbSNP
rs978457596 127 dbSNP
rs1220739591 128 dbSNP
rs570023755 135 dbSNP
rs756082460 136 dbSNP
rs1274463649 146 dbSNP
rs1043778693 156 dbSNP
rs1434636414 158 dbSNP
rs925478147 179 dbSNP
rs1257664486 193 dbSNP
rs1340204094 202 dbSNP
rs903866547 205 dbSNP
rs374526611 208 dbSNP
rs193050170 209 dbSNP
rs1002199672 210 dbSNP
rs1424952730 211 dbSNP
rs1050041758 232 dbSNP
rs1055761629 236 dbSNP
rs1452134864 239 dbSNP
rs1249524538 243 dbSNP
rs549044443 248 dbSNP
rs1451564827 262 dbSNP
rs556463770 264 dbSNP
rs1223787044 267 dbSNP
rs550079108 278 dbSNP
rs1014149671 282 dbSNP
rs912801833 283 dbSNP
rs1312525496 287 dbSNP
rs944261783 289 dbSNP
rs1477038377 290 dbSNP
rs140339914 292 dbSNP
rs534482273 303 dbSNP
rs951205015 304 dbSNP
rs768413813 305 dbSNP
rs1449342198 311 dbSNP
rs1359115769 315 dbSNP
rs1332544665 319 dbSNP
rs557532928 322 dbSNP
rs1169176029 326 dbSNP
rs995616142 328 dbSNP
rs1387870656 335 dbSNP
rs1048498092 346 dbSNP
rs1168904022 354 dbSNP
rs1016676141 359 dbSNP
rs1416822744 364 dbSNP
rs905730854 370 dbSNP
rs1001772466 372 dbSNP
rs1367294109 377 dbSNP
rs1483946733 393 dbSNP
rs1035490089 395 dbSNP
rs577819216 396 dbSNP
rs1010078326 399 dbSNP
rs1019925539 407 dbSNP
rs1228979385 413 dbSNP
rs1379001528 413 dbSNP
rs754444852 417 dbSNP
rs184580541 418 dbSNP
rs1371612609 419 dbSNP
rs921548233 421 dbSNP
rs1428663586 422 dbSNP
rs1282503157 424 dbSNP
rs557019009 425 dbSNP
rs573557470 426 dbSNP
rs146443607 429 dbSNP
rs1247417024 436 dbSNP
rs1294581063 439 dbSNP
rs1185776707 444 dbSNP
rs945533591 445 dbSNP
rs1252218596 447 dbSNP
rs1044236562 452 dbSNP
rs559458683 453 dbSNP
rs986033157 455 dbSNP
rs1479746109 456 dbSNP
rs1216313620 464 dbSNP
rs1267465356 465 dbSNP
rs1222399377 466 dbSNP
rs1291959145 468 dbSNP
rs912695119 482 dbSNP
rs542153774 484 dbSNP
rs1351681136 488 dbSNP
rs1288064609 491 dbSNP
rs140729901 510 dbSNP
rs1370716686 511 dbSNP
rs1294982205 513 dbSNP
rs541593824 517 dbSNP
rs1393149050 518 dbSNP
rs1037270883 520 dbSNP
rs918621500 523 dbSNP
rs1055141733 524 dbSNP
rs896463728 526 dbSNP
rs931297065 540 dbSNP
rs1014586836 541 dbSNP
rs1045615199 543 dbSNP
rs1192049006 544 dbSNP
rs564680864 549 dbSNP
rs1004046543 550 dbSNP
rs937408173 570 dbSNP
rs1017116548 578 dbSNP
rs776090054 583 dbSNP
rs1314358232 591 dbSNP
rs1297392885 597 dbSNP
rs1302914029 599 dbSNP
rs1386946742 600 dbSNP
rs533402092 604 dbSNP
rs761393897 605 dbSNP
rs188216317 609 dbSNP
rs1436648148 613 dbSNP
rs1384145763 615 dbSNP
rs1389285713 616 dbSNP
rs955002431 624 dbSNP
rs1020144402 626 dbSNP
rs1340015606 626 dbSNP
rs570344822 631 dbSNP
rs1317835872 637 dbSNP
rs1251387927 639 dbSNP
rs999812517 640 dbSNP
rs1239974216 642 dbSNP
rs1028616545 644 dbSNP
rs953254318 647 dbSNP
rs987467503 648 dbSNP
rs1484543929 665 dbSNP
rs1256901879 669 dbSNP
rs987207890 675 dbSNP
rs534834049 687 dbSNP
rs769148066 692 dbSNP
rs1020226860 693 dbSNP
rs1229960824 702 dbSNP
rs150075100 704 dbSNP
rs1353269788 720 dbSNP
rs1206597712 727 dbSNP
rs1380417885 730 dbSNP
rs181395056 737 dbSNP
rs1404297913 749 dbSNP
rs967322603 759 dbSNP
rs973016498 762 dbSNP
rs745721727 765 dbSNP
rs565788758 766 dbSNP
rs979608098 774 dbSNP
rs1170769558 775 dbSNP
rs925389766 786 dbSNP
rs938093256 787 dbSNP
rs1055173360 788 dbSNP
rs554186011 790 dbSNP
rs1183694285 791 dbSNP
rs917928718 800 dbSNP
rs574106269 805 dbSNP
rs949402905 811 dbSNP
rs1437750004 812 dbSNP
rs1046099805 814 dbSNP
rs1158209130 816 dbSNP
rs927288906 817 dbSNP
rs1200235301 818 dbSNP
rs1484930196 825 dbSNP
rs887012207 828 dbSNP
rs1057199012 830 dbSNP
rs1455145257 835 dbSNP
rs939877346 837 dbSNP
rs1038179331 838 dbSNP
rs898311417 848 dbSNP
rs1313436954 849 dbSNP
rs1413916400 854 dbSNP
rs1373439138 857 dbSNP
rs996555766 858 dbSNP
rs1430590881 860 dbSNP
rs1396053613 871 dbSNP
rs534800442 872 dbSNP
rs1182843650 885 dbSNP
rs1166164707 921 dbSNP
rs1453588600 925 dbSNP
rs74179468 926 dbSNP
rs904449909 928 dbSNP
rs1369540339 929 dbSNP
rs1077420 930 dbSNP
rs1029088026 935 dbSNP
rs1474338842 936 dbSNP
rs977642762 936 dbSNP
rs1308335087 940 dbSNP
rs924750842 942 dbSNP
rs1357906206 943 dbSNP
rs1265925082 947 dbSNP
rs933396966 948 dbSNP
rs571414842 953 dbSNP
rs1255725368 954 dbSNP
rs1322439158 957 dbSNP
rs1203840159 958 dbSNP
rs1264472060 960 dbSNP
rs1456057501 962 dbSNP
rs1176611989 965 dbSNP
rs1251110618 966 dbSNP
rs1289921691 967 dbSNP
rs1420704806 967 dbSNP
rs536874157 973 dbSNP
rs1335393140 975 dbSNP
rs1327169050 979 dbSNP
rs1108227 982 dbSNP
rs1007893544 983 dbSNP
rs1164342037 986 dbSNP
rs965577152 987 dbSNP
rs1414861011 988 dbSNP
rs1183265964 989 dbSNP
rs1178835850 1000 dbSNP
rs1470009914 1004 dbSNP
rs1021650878 1013 dbSNP
rs966975626 1015 dbSNP
rs1179269877 1017 dbSNP
rs573870490 1022 dbSNP
rs559837466 1024 dbSNP
rs980067492 1031 dbSNP
rs149441203 1037 dbSNP
rs1032513242 1043 dbSNP
rs1461519646 1050 dbSNP
rs1270010955 1052 dbSNP
rs959491397 1055 dbSNP
rs990935347 1066 dbSNP
rs1277975142 1069 dbSNP
rs1299297500 1070 dbSNP
rs553009653 1071 dbSNP
rs949437960 1082 dbSNP
rs983456691 1083 dbSNP
rs1025784016 1085 dbSNP
rs1346477860 1088 dbSNP
rs760172303 1089 dbSNP
rs1160632099 1096 dbSNP
rs1400456722 1098 dbSNP
rs1406184858 1113 dbSNP
rs1174697332 1114 dbSNP
rs1478771422 1118 dbSNP
rs1223804947 1127 dbSNP
rs907838336 1129 dbSNP
rs939971759 1130 dbSNP
rs1038212335 1134 dbSNP
rs898342399 1143 dbSNP
rs1249790465 1152 dbSNP
rs1216462328 1163 dbSNP
rs932479586 1168 dbSNP
rs952954560 1171 dbSNP
rs185685089 1173 dbSNP
rs545116391 1175 dbSNP
rs1008338900 1178 dbSNP
rs1348794566 1187 dbSNP
rs564877993 1188 dbSNP
rs1232168048 1190 dbSNP
rs1367506406 1192 dbSNP
rs1267989684 1202 dbSNP
rs1480638225 1203 dbSNP
rs1201917449 1204 dbSNP
rs1421729002 1205 dbSNP
rs1428093108 1206 dbSNP
rs937344214 1206 dbSNP
rs1415468806 1212 dbSNP
rs112110470 1214 dbSNP
rs1172678922 1215 dbSNP
rs753183736 1216 dbSNP
rs1391440969 1217 dbSNP
rs946093860 1221 dbSNP
rs1240293414 1228 dbSNP
rs1001123756 1233 dbSNP
rs893186 1234 dbSNP
rs925758818 1243 dbSNP
rs1208947398 1245 dbSNP
rs563979372 1246 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            | |||     | ||||||| 
Target 5' -cAAAGU-----GGUGAGAUU- 3'
1 - 15
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000336614.4 | 3UTR | CAAAGUGGUGAGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19350 CNS germ cell tumors -0.838 3.3e-4 -0.135 3.4e-1 12 Click to see details
GSE38226 Liver fibrosis -0.404 3.5e-2 -0.171 2.3e-1 21 Click to see details
GSE42095 Differentiated embryonic stem cells -0.373 4.0e-2 -0.329 6.3e-2 23 Click to see details
GSE28260 Renal cortex and medulla -0.405 8.5e-2 -0.438 6.7e-2 13 Click to see details
GSE14794 Lymphoblastoid cells -0.094 1.9e-1 -0.167 5.8e-2 90 Click to see details
GSE26953 Aortic valvular endothelial cells 0.159 2.3e-1 0.167 2.2e-1 24 Click to see details
GSE27834 Pluripotent stem cells -0.183 2.5e-1 -0.309 1.2e-1 16 Click to see details
GSE21687 Ependynoma primary tumors -0.085 2.5e-1 0.204 5.3e-2 64 Click to see details
GSE32688 Pancreatic cancer 0.112 2.7e-1 0.210 1.2e-1 32 Click to see details
GSE28544 Breast cancer 0.061 3.9e-1 0.027 4.5e-1 24 Click to see details
GSE17306 Multiple myeloma 0.038 4.0e-1 0.399 2.3e-3 49 Click to see details
GSE17498 Multiple myeloma -0.04 4.0e-1 0.026 4.4e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PAAD -0.97 0.02 -1.000 0.5 4 Click to see details
PRAD 0.35 0.03 0.245 0.09 31 Click to see details
HNSC -0.384 0.04 -0.359 0.05 23 Click to see details
THCA -0.208 0.08 -0.038 0.4 47 Click to see details
STAD 0.261 0.13 0.398 0.04 20 Click to see details
UCEC -0.344 0.17 -0.345 0.16 10 Click to see details
KIRC 0.173 0.18 -0.035 0.43 29 Click to see details
KIRP -0.198 0.22 -0.146 0.28 18 Click to see details
BLCA -0.237 0.25 0.091 0.4 10 Click to see details
ESCA 0.417 0.29 0.600 0.2 4 Click to see details
LUAD 0.186 0.32 0.200 0.3 9 Click to see details
LIHC -0.067 0.33 -0.082 0.3 45 Click to see details
KICH -0.08 0.41 -0.155 0.32 11 Click to see details
LUSC 0.037 0.44 -0.053 0.41 20 Click to see details
CHOL -0.033 0.47 -0.190 0.33 8 Click to see details
BRCA -0.014 0.47 0.015 0.47 25 Click to see details
BRCA -0.014 0.47 0.015 0.47 25 Click to see details
BRCA -0.014 0.47 0.015 0.47 25 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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