pre-miRNA Information
pre-miRNA hsa-mir-873   
Genomic Coordinates chr9: 28888879 - 28888955
Synonyms MIRN873, hsa-mir-873, MIR873
Description Homo sapiens miR-873 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-873-3p
Sequence 46| GGAGACUGAUGAGUUCCCGGGA |67
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760528397 3 dbSNP
rs773403294 9 dbSNP
rs1273846238 13 dbSNP
rs1339396073 15 dbSNP
rs1247999695 18 dbSNP
rs377380148 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DEFB105A   
Synonyms BD-5, DEFB-5, DEFB105
Description defensin beta 105A
Transcript NM_152250   
Expression
Putative miRNA Targets on DEFB105A
3'UTR of DEFB105A
(miRNA target sites are highlighted)
>DEFB105A|NM_152250|3'UTR
   1 CAAACCAGACCAGCACACTTCTGGCCTTAGAAGCAGACCTGG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agggccCUUGAG---UAGUCAGagg 5'
                |: ||:   | ||| |   
Target 5' acttctGGCCTTAGAAGCAGACctg 3'
17 - 41 72.00 -12.41
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs867745451 1 dbSNP
rs1421011423 8 dbSNP
rs1195450273 21 dbSNP
rs1428572725 26 dbSNP
rs865792200 39 dbSNP
rs868709792 56 dbSNP
rs1238424871 69 dbSNP
rs1161674106 70 dbSNP
rs1441088691 70 dbSNP
rs1472625965 73 dbSNP
rs866816885 80 dbSNP
rs199979796 81 dbSNP
rs1416526869 87 dbSNP
rs868754568 88 dbSNP
rs1403966140 93 dbSNP
rs1325569476 94 dbSNP
rs1190160969 96 dbSNP
rs1471547141 102 dbSNP
rs1251023022 111 dbSNP
rs1449349455 114 dbSNP
rs1329532142 115 dbSNP
rs1335286123 116 dbSNP
rs1205196988 120 dbSNP
rs1285911868 122 dbSNP
rs866671300 128 dbSNP
rs1258549108 133 dbSNP
rs1458918081 136 dbSNP
rs1287554688 137 dbSNP
rs1442527773 138 dbSNP
rs866586024 143 dbSNP
rs1472133321 151 dbSNP
rs1164814213 160 dbSNP
rs1467478692 162 dbSNP
rs1335074591 163 dbSNP
rs1274459187 164 dbSNP
rs1396694002 166 dbSNP
rs1336178480 169 dbSNP
rs1226063265 172 dbSNP
rs1278741924 173 dbSNP
rs1349390999 173 dbSNP
rs867568085 176 dbSNP
rs1250427121 177 dbSNP
rs1345204192 180 dbSNP
rs1453325881 188 dbSNP
rs1187914843 189 dbSNP
rs1201814074 189 dbSNP
rs1253534323 189 dbSNP
rs1323539801 189 dbSNP
rs1479017774 193 dbSNP
rs1279454168 195 dbSNP
rs1443645563 196 dbSNP
rs1174525146 197 dbSNP
rs1337888527 198 dbSNP
rs1434152624 199 dbSNP
rs866616647 202 dbSNP
rs1298767011 203 dbSNP
rs1322003201 204 dbSNP
rs1397919211 205 dbSNP
rs2737992 206 dbSNP
rs1395535760 207 dbSNP
rs531702559 209 dbSNP
rs867247515 210 dbSNP
rs1253849758 211 dbSNP
rs1455692697 217 dbSNP
rs1216634233 218 dbSNP
rs1287387876 221 dbSNP
rs1489521447 225 dbSNP
rs1411383801 230 dbSNP
rs868272331 231 dbSNP
rs1177710418 233 dbSNP
rs1434100744 234 dbSNP
rs1471125311 236 dbSNP
rs867458177 239 dbSNP
rs1393459799 240 dbSNP
rs1453895498 243 dbSNP
rs1244693791 249 dbSNP
rs867002720 252 dbSNP
rs1159258551 257 dbSNP
rs1197938912 259 dbSNP
rs1417846990 260 dbSNP
rs868323168 263 dbSNP
rs1388252574 264 dbSNP
rs562497058 264 dbSNP
rs1369710154 265 dbSNP
rs1240251618 267 dbSNP
rs1310905415 271 dbSNP
rs1350848467 273 dbSNP
rs1237592425 274 dbSNP
rs1260618611 283 dbSNP
rs1489030720 283 dbSNP
rs1211954807 284 dbSNP
rs865906069 285 dbSNP
rs1274637931 287 dbSNP
rs1468257122 288 dbSNP
rs1206478173 290 dbSNP
rs1382297665 291 dbSNP
rs1417363586 294 dbSNP
rs1158329291 295 dbSNP
rs1327860227 305 dbSNP
rs1459256994 308 dbSNP
rs1323572735 313 dbSNP
rs1393458642 314 dbSNP
rs1284414214 315 dbSNP
rs1224771128 316 dbSNP
rs1353474579 317 dbSNP
rs1306942174 318 dbSNP
rs1273404650 319 dbSNP
rs2737594 322 dbSNP
rs1372247647 323 dbSNP
rs1199549730 329 dbSNP
rs1240215775 330 dbSNP
rs1479710132 331 dbSNP
rs1176631736 332 dbSNP
rs1256779283 337 dbSNP
rs1425559431 342 dbSNP
rs1162691769 343 dbSNP
rs1416961710 344 dbSNP
rs1328137296 345 dbSNP
rs1433257342 348 dbSNP
rs1172414441 352 dbSNP
rs1352356244 353 dbSNP
rs1344677171 357 dbSNP
rs1159925165 361 dbSNP
rs200578731 362 dbSNP
rs1422998822 363 dbSNP
rs1171973021 364 dbSNP
rs1355258738 365 dbSNP
rs1454525935 369 dbSNP
rs1260247288 373 dbSNP
rs1305910498 377 dbSNP
rs1204091701 378 dbSNP
rs1256728183 379 dbSNP
rs1254730074 382 dbSNP
rs1185769326 385 dbSNP
rs1256671885 387 dbSNP
rs1186265129 388 dbSNP
rs1464170764 390 dbSNP
rs1416954325 391 dbSNP
rs1242123727 392 dbSNP
rs1176304911 395 dbSNP
rs1217353036 399 dbSNP
rs1449190922 401 dbSNP
rs1432280068 402 dbSNP
rs1355316166 406 dbSNP
rs1400994118 407 dbSNP
rs1277095572 413 dbSNP
rs1214261082 414 dbSNP
rs1302210613 417 dbSNP
rs1234256108 418 dbSNP
rs1349048091 426 dbSNP
rs1279540536 431 dbSNP
rs1306169046 435 dbSNP
rs1226369196 436 dbSNP
rs1240190548 437 dbSNP
rs1361560534 441 dbSNP
rs1289470359 443 dbSNP
rs1426771429 445 dbSNP
rs1452043391 446 dbSNP
rs1172399909 447 dbSNP
rs1432947048 448 dbSNP
rs1420901753 451 dbSNP
rs1320827293 453 dbSNP
rs1343848059 455 dbSNP
rs1294365449 456 dbSNP
rs1373397806 459 dbSNP
rs1357539458 461 dbSNP
rs1312194231 463 dbSNP
rs552563555 469 dbSNP
rs1396599290 470 dbSNP
rs1166489009 477 dbSNP
rs1221952102 486 dbSNP
rs1427515188 489 dbSNP
rs1248095277 495 dbSNP
rs1466910122 501 dbSNP
rs1192601032 505 dbSNP
rs1380433500 506 dbSNP
rs1440968416 509 dbSNP
rs1160837786 511 dbSNP
rs1419818795 512 dbSNP
rs199591139 514 dbSNP
rs1481973072 516 dbSNP
rs1397139033 517 dbSNP
rs1236460141 518 dbSNP
rs1439058846 522 dbSNP
rs1325435304 524 dbSNP
rs1210785970 527 dbSNP
rs1377781472 528 dbSNP
rs1444405500 529 dbSNP
rs1486295107 530 dbSNP
rs1349777773 531 dbSNP
rs1228810427 533 dbSNP
rs1282858655 537 dbSNP
rs1332388849 538 dbSNP
rs552783596 540 dbSNP
rs879877164 541 dbSNP
rs1307331234 547 dbSNP
rs1231676849 550 dbSNP
rs1010340219 552 dbSNP
rs1420524146 553 dbSNP
rs1164508860 554 dbSNP
rs1460163207 554 dbSNP
rs1401229379 555 dbSNP
rs1411731727 556 dbSNP
rs1216614016 560 dbSNP
rs1377046884 563 dbSNP
rs1292762127 564 dbSNP
rs1448728030 564 dbSNP
rs1353365893 566 dbSNP
rs1232406815 571 dbSNP
rs1415248800 572 dbSNP
rs1377234858 573 dbSNP
rs1305901747 575 dbSNP
rs532661359 580 dbSNP
rs1193715293 581 dbSNP
rs1461276701 583 dbSNP
rs1354938330 585 dbSNP
rs1172086448 590 dbSNP
rs1421750705 592 dbSNP
rs1189309276 597 dbSNP
rs1416456488 599 dbSNP
rs1188077940 601 dbSNP
rs1424776033 603 dbSNP
rs560826539 607 dbSNP
rs1415072365 608 dbSNP
rs1260198768 613 dbSNP
rs1180694995 617 dbSNP
rs1480507378 619 dbSNP
rs1252314638 620 dbSNP
rs1413946777 623 dbSNP
rs1278677885 630 dbSNP
rs2737596 633 dbSNP
rs180741456 639 dbSNP
rs1224851062 640 dbSNP
rs1320146953 645 dbSNP
rs1345135820 647 dbSNP
rs1272584249 651 dbSNP
rs1283094182 655 dbSNP
rs1234002947 661 dbSNP
rs1485013586 662 dbSNP
rs1210777665 663 dbSNP
rs1357505494 666 dbSNP
rs1430629834 667 dbSNP
rs1372673379 668 dbSNP
rs1286349874 669 dbSNP
rs540601959 670 dbSNP
rs1175529837 673 dbSNP
rs1393343404 674 dbSNP
rs1390819818 676 dbSNP
rs1434091443 678 dbSNP
rs1373775463 682 dbSNP
rs2737597 683 dbSNP
rs1331256752 685 dbSNP
rs1456004954 692 dbSNP
rs1393300940 693 dbSNP
rs575084983 696 dbSNP
rs1462527250 698 dbSNP
rs199518207 704 dbSNP
rs1203702082 705 dbSNP
rs1409213497 709 dbSNP
rs890602839 710 dbSNP
rs1195719796 713 dbSNP
rs2737598 714 dbSNP
rs1251607277 715 dbSNP
rs1159772138 719 dbSNP
rs561507895 724 dbSNP
rs1451364416 731 dbSNP
rs1157848324 734 dbSNP
rs1467273106 740 dbSNP
rs1442706253 742 dbSNP
rs1323437926 744 dbSNP
rs1369647597 751 dbSNP
rs1446821654 754 dbSNP
rs1308359420 755 dbSNP
rs879654704 756 dbSNP
rs1214598892 758 dbSNP
rs1337037597 765 dbSNP
rs1215832933 766 dbSNP
rs1251332167 767 dbSNP
rs1468100972 775 dbSNP
rs1177785494 778 dbSNP
rs1266381140 779 dbSNP
rs1252749387 782 dbSNP
rs879482111 785 dbSNP
rs1180966712 788 dbSNP
rs1418354606 793 dbSNP
rs1162375646 808 dbSNP
rs1393206843 817 dbSNP
rs1317455187 819 dbSNP
rs1299454988 820 dbSNP
rs1370524045 844 dbSNP
rs1390218233 845 dbSNP
rs1308809802 846 dbSNP
rs1384838265 852 dbSNP
rs1370028216 858 dbSNP
rs1235460483 862 dbSNP
rs1271512069 871 dbSNP
rs1334521254 877 dbSNP
rs1326160254 881 dbSNP
rs1442721593 884 dbSNP
rs1479678462 892 dbSNP
rs1385731644 893 dbSNP
rs1258075969 898 dbSNP
rs1476074261 907 dbSNP
rs1185452016 913 dbSNP
rs1157488093 914 dbSNP
rs1453625967 915 dbSNP
rs1172060644 917 dbSNP
rs200362687 919 dbSNP
rs1161978074 921 dbSNP
rs1461010876 922 dbSNP
rs1307987950 925 dbSNP
rs202180694 928 dbSNP
rs1417155845 931 dbSNP
rs1291886341 937 dbSNP
rs1378870779 941 dbSNP
rs1394927629 952 dbSNP
rs1297942651 957 dbSNP
rs1305858260 967 dbSNP
rs1203833282 975 dbSNP
rs1194492632 979 dbSNP
rs1470006266 986 dbSNP
rs1208629756 1001 dbSNP
rs1256604612 1003 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' agggcccuugaguagUCAGAGg 5'
                         |||||| 
Target 5' ------------aggAGUCUCa 3'
1 - 10
2
miRNA  3' aggGCCCUUGAGUAGUCAgagg 5'
             | |||::    ||||    
Target 5' aggCUGGAGU---GCAGUggcu 3'
22 - 40
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000334773.6 | 3UTR | AGGAGUCUCACUCUGUCGCCCAGGCUGGAGUGCAGUGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000334773.6 | 3UTR | AGAAGGAGUCUCACUCUGUCGCCCAGGCUGGAGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-873-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT081178 MIDN midnolin 2 4
MIRT109809 ZFX zinc finger protein, X-linked 2 4
MIRT242383 TMC5 transmembrane channel like 5 2 4
MIRT444003 METRN meteorin, glial cell differentiation regulator 2 4
MIRT444097 SEPHS1 selenophosphate synthetase 1 2 2
MIRT446158 RPL12 ribosomal protein L12 2 2
MIRT446859 SAMD9L sterile alpha motif domain containing 9 like 2 2
MIRT447275 FZD5 frizzled class receptor 5 2 2
MIRT447391 TMPRSS15 transmembrane protease, serine 15 2 2
MIRT448817 FKBP1A FK506 binding protein 1A 2 4
MIRT450582 HIST1H2BG histone cluster 1 H2B family member g 2 2
MIRT451776 USP36 ubiquitin specific peptidase 36 2 2
MIRT457961 ABCC5 ATP binding cassette subfamily C member 5 2 4
MIRT458424 KLHL38 kelch like family member 38 2 4
MIRT461383 SLFN12L schlafen family member 12 like 2 2
MIRT467793 SLC2A14 solute carrier family 2 member 14 2 2
MIRT476517 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT480290 C7orf73 short transmembrane mitochondrial protein 1 2 4
MIRT482745 HES7 hes family bHLH transcription factor 7 2 10
MIRT483189 HIST1H2AH histone cluster 1 H2A family member h 2 6
MIRT486545 DCTN4 dynactin subunit 4 2 2
MIRT486581 ZNF619 zinc finger protein 619 2 2
MIRT492604 POLR3E RNA polymerase III subunit E 2 2
MIRT494130 DCAF7 DDB1 and CUL4 associated factor 7 2 6
MIRT496023 ZBED3 zinc finger BED-type containing 3 2 2
MIRT497121 NBEAL1 neurobeachin like 1 2 2
MIRT497400 TMEM245 transmembrane protein 245 2 2
MIRT501410 RANBP10 RAN binding protein 10 2 2
MIRT510947 PPTC7 PTC7 protein phosphatase homolog 2 6
MIRT512494 ARID2 AT-rich interaction domain 2 2 2
MIRT512595 ZNF783 zinc finger family member 783 2 2
MIRT512612 CNTN4 contactin 4 2 2
MIRT517808 UGDH UDP-glucose 6-dehydrogenase 2 6
MIRT520686 TMED7 transmembrane p24 trafficking protein 7 2 4
MIRT526179 HEPH hephaestin 2 2
MIRT532568 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT533979 TADA2A transcriptional adaptor 2A 2 2
MIRT538622 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539703 EIF3H eukaryotic translation initiation factor 3 subunit H 2 2
MIRT539806 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT540422 FAM83F family with sequence similarity 83 member F 2 2
MIRT540506 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT540619 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT542423 ZNF331 zinc finger protein 331 2 2
MIRT542454 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT543383 CC2D2A coiled-coil and C2 domain containing 2A 2 2
MIRT544777 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT544923 ERCC4 ERCC excision repair 4, endonuclease catalytic subunit 2 2
MIRT549768 ZNF611 zinc finger protein 611 2 4
MIRT551242 COLEC10 collectin subfamily member 10 2 2
MIRT560474 ENSA endosulfine alpha 2 2
MIRT569738 GPR173 G protein-coupled receptor 173 2 2
MIRT571297 CHCHD4 coiled-coil-helix-coiled-coil-helix domain containing 4 2 2
MIRT572345 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT573112 ERBB2IP erbb2 interacting protein 2 2
MIRT607744 ANGPT4 angiopoietin 4 2 2
MIRT607903 SPRYD4 SPRY domain containing 4 2 2
MIRT611744 SERPING1 serpin family G member 1 2 4
MIRT615101 BNC2 basonuclin 2 2 2
MIRT619124 CD40LG CD40 ligand 2 2
MIRT625572 ANKRD42 ankyrin repeat domain 42 2 2
MIRT629038 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT633986 SLC35E2 solute carrier family 35 member E2 2 2
MIRT635675 COX18 COX18, cytochrome c oxidase assembly factor 2 4
MIRT637471 DEFB105B defensin beta 105B 2 4
MIRT637503 DEFB105A defensin beta 105A 2 4
MIRT639735 MAP2K2 mitogen-activated protein kinase kinase 2 2 2
MIRT640730 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT645364 C9orf47 chromosome 9 open reading frame 47 2 2
MIRT647938 RNF152 ring finger protein 152 2 2
MIRT649400 SH2D4A SH2 domain containing 4A 2 2
MIRT656860 KIN Kin17 DNA and RNA binding protein 2 2
MIRT663470 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT663507 NKAPL NFKB activating protein like 2 4
MIRT667690 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT677403 PCNP PEST proteolytic signal containing nuclear protein 2 2
MIRT678682 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT678789 NUPL2 nucleoporin like 2 2 2
MIRT680649 KIAA1456 KIAA1456 2 2
MIRT682450 MTX3 metaxin 3 2 2
MIRT682740 CA6 carbonic anhydrase 6 2 2
MIRT684421 TUFT1 tuftelin 1 2 2
MIRT690535 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT690595 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT690771 PLA2G2C phospholipase A2 group IIC 2 2
MIRT692233 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT693667 MXRA7 matrix remodeling associated 7 2 2
MIRT695551 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT695870 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT696214 LYZ lysozyme 2 2
MIRT698368 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT700795 PHTF2 putative homeodomain transcription factor 2 2 2
MIRT701640 MYLK3 myosin light chain kinase 3 2 2
MIRT702989 HERPUD2 HERPUD family member 2 2 2
MIRT703627 FBXL3 F-box and leucine rich repeat protein 3 2 2
MIRT703783 FAM102B family with sequence similarity 102 member B 2 2
MIRT704293 DDX19B DEAD-box helicase 19B 2 2
MIRT704828 CDC73 cell division cycle 73 2 2
MIRT705014 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT708480 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT710770 PHF7 PHD finger protein 7 2 2
MIRT718918 TRIM66 tripartite motif containing 66 2 2
MIRT720390 ZNF549 zinc finger protein 549 2 2
MIRT720593 TTC39C tetratricopeptide repeat domain 39C 2 2
MIRT723515 SIGLEC8 sialic acid binding Ig like lectin 8 2 2
MIRT724458 PRKX protein kinase, X-linked 2 2
MIRT737267 UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 3 0
MIRT737356 ZIC2 Zic family member 2 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-873 Dexamethasone approved 5743 Microarray adrenals and granulosa cells 24205079 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-873 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-873 Cisplatin 5460033 NSC119875 approved resistant cell line (OE19)
hsa-mir-873 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-873 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-873-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-873-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-873-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-873-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-873-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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