pre-miRNA Information
pre-miRNA hsa-mir-4486   
Genomic Coordinates chr11: 19575310 - 19575372
Description Homo sapiens miR-4486 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4486
Sequence 5| GCUGGGCGAGGCUGGCA |21
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs774299284 8 dbSNP
rs902172817 14 dbSNP
rs1222795726 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DEFB105A   
Synonyms BD-5, DEFB-5, DEFB105
Description defensin beta 105A
Transcript NM_152250   
Expression
Putative miRNA Targets on DEFB105A
3'UTR of DEFB105A
(miRNA target sites are highlighted)
>DEFB105A|NM_152250|3'UTR
   1 CAAACCAGACCAGCACACTTCTGGCCTTAGAAGCAGACCTGG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acggucggagCGGGUCg 5'
                    | |||| 
Target 5' ---caaaccaGACCAGc 3'
1 - 14 88.00 -13.20
2
miRNA  3' acGGUCG------GAGCGG-GUCG 5'
            |||||      || ||| :|| 
Target 5' gaCCAGCACACTTCTGGCCTTAGA 3'
8 - 31 77.00 -15.02
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs867745451 1 dbSNP
rs1421011423 8 dbSNP
rs1195450273 21 dbSNP
rs1428572725 26 dbSNP
rs865792200 39 dbSNP
rs868709792 56 dbSNP
rs1238424871 69 dbSNP
rs1161674106 70 dbSNP
rs1441088691 70 dbSNP
rs1472625965 73 dbSNP
rs866816885 80 dbSNP
rs199979796 81 dbSNP
rs1416526869 87 dbSNP
rs868754568 88 dbSNP
rs1403966140 93 dbSNP
rs1325569476 94 dbSNP
rs1190160969 96 dbSNP
rs1471547141 102 dbSNP
rs1251023022 111 dbSNP
rs1449349455 114 dbSNP
rs1329532142 115 dbSNP
rs1335286123 116 dbSNP
rs1205196988 120 dbSNP
rs1285911868 122 dbSNP
rs866671300 128 dbSNP
rs1258549108 133 dbSNP
rs1458918081 136 dbSNP
rs1287554688 137 dbSNP
rs1442527773 138 dbSNP
rs866586024 143 dbSNP
rs1472133321 151 dbSNP
rs1164814213 160 dbSNP
rs1467478692 162 dbSNP
rs1335074591 163 dbSNP
rs1274459187 164 dbSNP
rs1396694002 166 dbSNP
rs1336178480 169 dbSNP
rs1226063265 172 dbSNP
rs1278741924 173 dbSNP
rs1349390999 173 dbSNP
rs867568085 176 dbSNP
rs1250427121 177 dbSNP
rs1345204192 180 dbSNP
rs1453325881 188 dbSNP
rs1187914843 189 dbSNP
rs1201814074 189 dbSNP
rs1253534323 189 dbSNP
rs1323539801 189 dbSNP
rs1479017774 193 dbSNP
rs1279454168 195 dbSNP
rs1443645563 196 dbSNP
rs1174525146 197 dbSNP
rs1337888527 198 dbSNP
rs1434152624 199 dbSNP
rs866616647 202 dbSNP
rs1298767011 203 dbSNP
rs1322003201 204 dbSNP
rs1397919211 205 dbSNP
rs2737992 206 dbSNP
rs1395535760 207 dbSNP
rs531702559 209 dbSNP
rs867247515 210 dbSNP
rs1253849758 211 dbSNP
rs1455692697 217 dbSNP
rs1216634233 218 dbSNP
rs1287387876 221 dbSNP
rs1489521447 225 dbSNP
rs1411383801 230 dbSNP
rs868272331 231 dbSNP
rs1177710418 233 dbSNP
rs1434100744 234 dbSNP
rs1471125311 236 dbSNP
rs867458177 239 dbSNP
rs1393459799 240 dbSNP
rs1453895498 243 dbSNP
rs1244693791 249 dbSNP
rs867002720 252 dbSNP
rs1159258551 257 dbSNP
rs1197938912 259 dbSNP
rs1417846990 260 dbSNP
rs868323168 263 dbSNP
rs1388252574 264 dbSNP
rs562497058 264 dbSNP
rs1369710154 265 dbSNP
rs1240251618 267 dbSNP
rs1310905415 271 dbSNP
rs1350848467 273 dbSNP
rs1237592425 274 dbSNP
rs1260618611 283 dbSNP
rs1489030720 283 dbSNP
rs1211954807 284 dbSNP
rs865906069 285 dbSNP
rs1274637931 287 dbSNP
rs1468257122 288 dbSNP
rs1206478173 290 dbSNP
rs1382297665 291 dbSNP
rs1417363586 294 dbSNP
rs1158329291 295 dbSNP
rs1327860227 305 dbSNP
rs1459256994 308 dbSNP
rs1323572735 313 dbSNP
rs1393458642 314 dbSNP
rs1284414214 315 dbSNP
rs1224771128 316 dbSNP
rs1353474579 317 dbSNP
rs1306942174 318 dbSNP
rs1273404650 319 dbSNP
rs2737594 322 dbSNP
rs1372247647 323 dbSNP
rs1199549730 329 dbSNP
rs1240215775 330 dbSNP
rs1479710132 331 dbSNP
rs1176631736 332 dbSNP
rs1256779283 337 dbSNP
rs1425559431 342 dbSNP
rs1162691769 343 dbSNP
rs1416961710 344 dbSNP
rs1328137296 345 dbSNP
rs1433257342 348 dbSNP
rs1172414441 352 dbSNP
rs1352356244 353 dbSNP
rs1344677171 357 dbSNP
rs1159925165 361 dbSNP
rs200578731 362 dbSNP
rs1422998822 363 dbSNP
rs1171973021 364 dbSNP
rs1355258738 365 dbSNP
rs1454525935 369 dbSNP
rs1260247288 373 dbSNP
rs1305910498 377 dbSNP
rs1204091701 378 dbSNP
rs1256728183 379 dbSNP
rs1254730074 382 dbSNP
rs1185769326 385 dbSNP
rs1256671885 387 dbSNP
rs1186265129 388 dbSNP
rs1464170764 390 dbSNP
rs1416954325 391 dbSNP
rs1242123727 392 dbSNP
rs1176304911 395 dbSNP
rs1217353036 399 dbSNP
rs1449190922 401 dbSNP
rs1432280068 402 dbSNP
rs1355316166 406 dbSNP
rs1400994118 407 dbSNP
rs1277095572 413 dbSNP
rs1214261082 414 dbSNP
rs1302210613 417 dbSNP
rs1234256108 418 dbSNP
rs1349048091 426 dbSNP
rs1279540536 431 dbSNP
rs1306169046 435 dbSNP
rs1226369196 436 dbSNP
rs1240190548 437 dbSNP
rs1361560534 441 dbSNP
rs1289470359 443 dbSNP
rs1426771429 445 dbSNP
rs1452043391 446 dbSNP
rs1172399909 447 dbSNP
rs1432947048 448 dbSNP
rs1420901753 451 dbSNP
rs1320827293 453 dbSNP
rs1343848059 455 dbSNP
rs1294365449 456 dbSNP
rs1373397806 459 dbSNP
rs1357539458 461 dbSNP
rs1312194231 463 dbSNP
rs552563555 469 dbSNP
rs1396599290 470 dbSNP
rs1166489009 477 dbSNP
rs1221952102 486 dbSNP
rs1427515188 489 dbSNP
rs1248095277 495 dbSNP
rs1466910122 501 dbSNP
rs1192601032 505 dbSNP
rs1380433500 506 dbSNP
rs1440968416 509 dbSNP
rs1160837786 511 dbSNP
rs1419818795 512 dbSNP
rs199591139 514 dbSNP
rs1481973072 516 dbSNP
rs1397139033 517 dbSNP
rs1236460141 518 dbSNP
rs1439058846 522 dbSNP
rs1325435304 524 dbSNP
rs1210785970 527 dbSNP
rs1377781472 528 dbSNP
rs1444405500 529 dbSNP
rs1486295107 530 dbSNP
rs1349777773 531 dbSNP
rs1228810427 533 dbSNP
rs1282858655 537 dbSNP
rs1332388849 538 dbSNP
rs552783596 540 dbSNP
rs879877164 541 dbSNP
rs1307331234 547 dbSNP
rs1231676849 550 dbSNP
rs1010340219 552 dbSNP
rs1420524146 553 dbSNP
rs1164508860 554 dbSNP
rs1460163207 554 dbSNP
rs1401229379 555 dbSNP
rs1411731727 556 dbSNP
rs1216614016 560 dbSNP
rs1377046884 563 dbSNP
rs1292762127 564 dbSNP
rs1448728030 564 dbSNP
rs1353365893 566 dbSNP
rs1232406815 571 dbSNP
rs1415248800 572 dbSNP
rs1377234858 573 dbSNP
rs1305901747 575 dbSNP
rs532661359 580 dbSNP
rs1193715293 581 dbSNP
rs1461276701 583 dbSNP
rs1354938330 585 dbSNP
rs1172086448 590 dbSNP
rs1421750705 592 dbSNP
rs1189309276 597 dbSNP
rs1416456488 599 dbSNP
rs1188077940 601 dbSNP
rs1424776033 603 dbSNP
rs560826539 607 dbSNP
rs1415072365 608 dbSNP
rs1260198768 613 dbSNP
rs1180694995 617 dbSNP
rs1480507378 619 dbSNP
rs1252314638 620 dbSNP
rs1413946777 623 dbSNP
rs1278677885 630 dbSNP
rs2737596 633 dbSNP
rs180741456 639 dbSNP
rs1224851062 640 dbSNP
rs1320146953 645 dbSNP
rs1345135820 647 dbSNP
rs1272584249 651 dbSNP
rs1283094182 655 dbSNP
rs1234002947 661 dbSNP
rs1485013586 662 dbSNP
rs1210777665 663 dbSNP
rs1357505494 666 dbSNP
rs1430629834 667 dbSNP
rs1372673379 668 dbSNP
rs1286349874 669 dbSNP
rs540601959 670 dbSNP
rs1175529837 673 dbSNP
rs1393343404 674 dbSNP
rs1390819818 676 dbSNP
rs1434091443 678 dbSNP
rs1373775463 682 dbSNP
rs2737597 683 dbSNP
rs1331256752 685 dbSNP
rs1456004954 692 dbSNP
rs1393300940 693 dbSNP
rs575084983 696 dbSNP
rs1462527250 698 dbSNP
rs199518207 704 dbSNP
rs1203702082 705 dbSNP
rs1409213497 709 dbSNP
rs890602839 710 dbSNP
rs1195719796 713 dbSNP
rs2737598 714 dbSNP
rs1251607277 715 dbSNP
rs1159772138 719 dbSNP
rs561507895 724 dbSNP
rs1451364416 731 dbSNP
rs1157848324 734 dbSNP
rs1467273106 740 dbSNP
rs1442706253 742 dbSNP
rs1323437926 744 dbSNP
rs1369647597 751 dbSNP
rs1446821654 754 dbSNP
rs1308359420 755 dbSNP
rs879654704 756 dbSNP
rs1214598892 758 dbSNP
rs1337037597 765 dbSNP
rs1215832933 766 dbSNP
rs1251332167 767 dbSNP
rs1468100972 775 dbSNP
rs1177785494 778 dbSNP
rs1266381140 779 dbSNP
rs1252749387 782 dbSNP
rs879482111 785 dbSNP
rs1180966712 788 dbSNP
rs1418354606 793 dbSNP
rs1162375646 808 dbSNP
rs1393206843 817 dbSNP
rs1317455187 819 dbSNP
rs1299454988 820 dbSNP
rs1370524045 844 dbSNP
rs1390218233 845 dbSNP
rs1308809802 846 dbSNP
rs1384838265 852 dbSNP
rs1370028216 858 dbSNP
rs1235460483 862 dbSNP
rs1271512069 871 dbSNP
rs1334521254 877 dbSNP
rs1326160254 881 dbSNP
rs1442721593 884 dbSNP
rs1479678462 892 dbSNP
rs1385731644 893 dbSNP
rs1258075969 898 dbSNP
rs1476074261 907 dbSNP
rs1185452016 913 dbSNP
rs1157488093 914 dbSNP
rs1453625967 915 dbSNP
rs1172060644 917 dbSNP
rs200362687 919 dbSNP
rs1161978074 921 dbSNP
rs1461010876 922 dbSNP
rs1307987950 925 dbSNP
rs202180694 928 dbSNP
rs1417155845 931 dbSNP
rs1291886341 937 dbSNP
rs1378870779 941 dbSNP
rs1394927629 952 dbSNP
rs1297942651 957 dbSNP
rs1305858260 967 dbSNP
rs1203833282 975 dbSNP
rs1194492632 979 dbSNP
rs1470006266 986 dbSNP
rs1208629756 1001 dbSNP
rs1256604612 1003 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acGGUCGG--AGCGGGUCg 5'
            :|| :|  |||||||| 
Target 5' ucUCACUCUGUCGCCCAGg 3'
6 - 24
Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acGGUCGG--AGCGGGUCg 5'
            :|| :|  |||||||| 
Target 5' ucUCACUCUGUCGCCCAGg 3'
9 - 27
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000334773.6 | 3UTR | AGGAGUCUCACUCUGUCGCCCAGGCUGGAGUGCAGUGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000334773.6 | 3UTR | AGAAGGAGUCUCACUCUGUCGCCCAGGCUGGAGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
108 hsa-miR-4486 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT254654 NF2 neurofibromin 2 2 2
MIRT458684 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT470845 PLXND1 plexin D1 2 2
MIRT493011 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT497264 GRK6 G protein-coupled receptor kinase 6 2 2
MIRT497675 SYNGR1 synaptogyrin 1 2 2
MIRT498219 TLN2 talin 2 2 2
MIRT498310 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT504048 TOMM5 translocase of outer mitochondrial membrane 5 2 2
MIRT519959 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT531521 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT533144 WNT10A Wnt family member 10A 2 2
MIRT533541 TPR translocated promoter region, nuclear basket protein 2 2
MIRT533681 TMEM86A transmembrane protein 86A 2 2
MIRT540321 PIGR polymeric immunoglobulin receptor 2 2
MIRT540719 GUF1 GUF1 homolog, GTPase 2 2
MIRT541566 ZNF43 zinc finger protein 43 2 4
MIRT541787 TBCCD1 TBCC domain containing 1 2 2
MIRT541925 ORC1 origin recognition complex subunit 1 2 4
MIRT542232 FUT9 fucosyltransferase 9 2 2
MIRT542285 POLR3K RNA polymerase III subunit K 2 2
MIRT542299 QTRTD1 queuine tRNA-ribosyltransferase accessory subunit 2 2 4
MIRT542368 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT542441 C3 complement C3 2 4
MIRT542475 APOC3 apolipoprotein C3 2 2
MIRT542535 MRPS10 mitochondrial ribosomal protein S10 2 2
MIRT542640 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT542788 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT552104 PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A 2 2
MIRT564913 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT568606 ACVR2A activin A receptor type 2A 2 2
MIRT607389 LANCL3 LanC like 3 2 2
MIRT607451 ZNF543 zinc finger protein 543 2 2
MIRT610058 MYBPC1 myosin binding protein C, slow type 2 2
MIRT610793 KLK2 kallikrein related peptidase 2 2 2
MIRT617176 GOSR2 golgi SNAP receptor complex member 2 2 2
MIRT620579 WBSCR27 methyltransferase like 27 2 4
MIRT622085 SRPX2 sushi repeat containing protein, X-linked 2 2 2
MIRT622542 PXMP4 peroxisomal membrane protein 4 2 2
MIRT630009 PDE6B phosphodiesterase 6B 2 2
MIRT631813 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT632721 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT632757 MED28 mediator complex subunit 28 2 2
MIRT634821 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT635255 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT637082 SELPLG selectin P ligand 2 2
MIRT637357 ZNF460 zinc finger protein 460 2 2
MIRT637472 DEFB105B defensin beta 105B 2 4
MIRT637504 DEFB105A defensin beta 105A 2 4
MIRT639022 AAK1 AP2 associated kinase 1 2 2
MIRT641012 ANKFY1 ankyrin repeat and FYVE domain containing 1 2 2
MIRT642170 HEBP2 heme binding protein 2 2 2
MIRT648977 ACAD8 acyl-CoA dehydrogenase family member 8 2 2
MIRT650515 UFM1 ubiquitin fold modifier 1 2 2
MIRT650949 INMT indolethylamine N-methyltransferase 2 2
MIRT658354 FAM65B RHO family interacting cell polarization regulator 2 2 2
MIRT660736 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT662191 MEI1 meiotic double-stranded break formation protein 1 2 2
MIRT663045 SLC16A4 solute carrier family 16 member 4 2 2
MIRT664811 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT665161 SF3A1 splicing factor 3a subunit 1 2 4
MIRT665346 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT666493 SBNO1 strawberry notch homolog 1 2 2
MIRT666545 RNF115 ring finger protein 115 2 2
MIRT669351 BMP3 bone morphogenetic protein 3 2 2
MIRT669904 KIAA0754 KIAA0754 2 4
MIRT670323 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT670430 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT670672 KIAA1551 KIAA1551 2 2
MIRT670746 HOOK3 hook microtubule tethering protein 3 2 2
MIRT670998 PTGIS prostaglandin I2 synthase 2 2
MIRT671290 RPL37A ribosomal protein L37a 2 2
MIRT671469 AGPAT6 glycerol-3-phosphate acyltransferase 4 2 2
MIRT671833 STIL STIL, centriolar assembly protein 2 2
MIRT673006 TAF1 TATA-box binding protein associated factor 1 2 2
MIRT675881 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT678625 OLFML2A olfactomedin like 2A 2 2
MIRT678790 NUPL2 nucleoporin like 2 2 2
MIRT679560 LIN9 lin-9 DREAM MuvB core complex component 2 2
MIRT681032 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682480 LIX1L limb and CNS expressed 1 like 2 2
MIRT682758 MDM2 MDM2 proto-oncogene 2 2
MIRT682810 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT682867 C9orf156 tRNA methyltransferase O 2 2
MIRT689233 RPS19 ribosomal protein S19 2 2
MIRT689305 C5AR2 complement component 5a receptor 2 2 2
MIRT689363 ZNF101 zinc finger protein 101 2 2
MIRT689629 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT689654 RBM23 RNA binding motif protein 23 2 2
MIRT690148 PPIL6 peptidylprolyl isomerase like 6 2 2
MIRT691407 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT691847 OSCAR osteoclast associated, immunoglobulin-like receptor 2 2
MIRT692234 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT694320 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT694365 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT696215 LYZ lysozyme 2 2
MIRT697230 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT700487 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700612 PRKCA protein kinase C alpha 2 2
MIRT702456 KIAA1467 family with sequence similarity 234 member B 2 2
MIRT702990 HERPUD2 HERPUD family member 2 2 2
MIRT703998 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT704701 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT712481 FSTL3 follistatin like 3 2 2
MIRT712781 ZNF154 zinc finger protein 154 2 2
MIRT714369 HP1BP3 heterochromatin protein 1 binding protein 3 2 2
MIRT722570 C1orf95 stum, mechanosensory transduction mediator homolog 2 2
MIRT722839 C17orf102 chromosome 17 open reading frame 102 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4486 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4486 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC-7901)
hsa-mir-4486 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4486 Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4486 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-4486 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4486 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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