pre-miRNA Information
pre-miRNA hsa-mir-4763   
Genomic Coordinates chr22: 46113566 - 46113657
Description Homo sapiens miR-4763 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4763-5p
Sequence 19| CGCCUGCCCAGCCCUCCUGCU |39
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs374776264 1 dbSNP
rs1174502793 2 dbSNP
rs966122637 3 dbSNP
rs891363409 6 dbSNP
rs1303008773 8 dbSNP
rs1446379219 11 dbSNP
rs1410535134 13 dbSNP
rs1424733379 14 dbSNP
rs1372551711 16 dbSNP
rs756995936 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF439   
Synonyms -
Description zinc finger protein 439
Transcript NM_152262   
Expression
Putative miRNA Targets on ZNF439
3'UTR of ZNF439
(miRNA target sites are highlighted)
>ZNF439|NM_152262|3'UTR
   1 ATATAAGATATATGGGAAACACTTTTATTCTGCCAAGTTATTTCAAACACATGAAAAAATTCACACTGGAGAGAAACCCT
  81 ATAAATGCAAGCAATGTGGTAAAGCCTTAATTGTTCCAGTTCCTTTCGATATCTAAAAGGACTCACAGTGGAGAAAAACT
 161 CTATGAGTGTAAGCAATGTGGGAAAGTCTTCAGATCTGTCAAGAACCTTTCAATTTATGAAAGGACACACACTGGAGAGA
 241 AACCCTATGAATGTAAGAAATGTGGAAAAGCGTTCCATAATTTCTCTTCTTTTCAAATACATGAAAGTTGCACAGAGGAG
 321 AGGCGCCCTAAGAATGTAAGCATTGTGGGAAAGCATTCATATCTGCCAAGATCGTTTGAATACATGCAAAACACACACTG
 401 GAGAGAAACCTATGAATGTAAGGAATGCAAACAAGCATTCAATTATTTTTCTTCCTTGCATATACATGAAAGGACTCATA
 481 CGAGAGAGAATCCGTATGAATGTAAGGATTGTGGGAAAGCATTCAGCTTGCTTAATTGCTTTCATAGACATGTAAAGACA
 561 CACCAGAAGGAAACCCTATGAATGTAAGCAATGTGGCAAAAGCTTTCACTTCTTCCAGTTCTTTTCAATATCATGAAAGG
 641 ACTCACACTGGGGAGAAACCGTATCAATGTAAGCAATGTGGGAAAGCCGTCAGATCAGCCTCAAGACTTCAAATGCATGG
 721 AAGCACTCACACTTGGCAGAAACTCTATGAATGTAAGCAGTATGGGAAAGCCTTCAGATCGGCTAGGATTCTTTGAATAC
 801 AAATAATGAATGTAAACAATTAACTGTTTATAATAACTGTATACTAACAAATGTTATTCTTTTTAAATAATTAAGAAGCT
 881 ATAATAAAATATCCATTGGTGTCATGTATTAGATCAAGCTTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ucguccucccGACCCGUCcgc 5'
                    || |||||   
Target 5' agcactcacaCTTGGCAGaaa 3'
722 - 742 107.00 -8.92
2
miRNA  3' ucgUCCUCCCGACCCGUCCGc 5'
             ||||  | |||| | || 
Target 5' gtaAGGATTG-TGGGAAAGCa 3'
502 - 521 97.00 -11.00
3
miRNA  3' ucguccuccCGACCCG-UCCgc 5'
                   | | ||| |||  
Target 5' aagccttcaGATCGGCTAGGat 3'
768 - 789 92.00 -9.66
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31557645 8 COSMIC
COSN31574000 8 COSMIC
COSN30177258 45 COSMIC
COSN30458763 69 COSMIC
COSN30519975 70 COSMIC
COSN31492803 77 COSMIC
COSN30136543 85 COSMIC
COSN30513910 92 COSMIC
COSN30111295 97 COSMIC
COSN22262299 115 COSMIC
COSN28758045 117 COSMIC
COSN30624528 118 COSMIC
COSN13780028 128 COSMIC
COSN27006118 149 COSMIC
COSN30152752 162 COSMIC
COSN30447498 185 COSMIC
COSN31583641 186 COSMIC
COSN1210809 197 COSMIC
COSN30193327 220 COSMIC
COSN28681819 253 COSMIC
COSN31572976 254 COSMIC
COSN30115685 267 COSMIC
COSN5268441 277 COSMIC
COSN30120581 285 COSMIC
COSN30121540 290 COSMIC
COSN31529144 313 COSMIC
COSN31581056 390 COSMIC
COSN30501431 393 COSMIC
COSN31554685 468 COSMIC
COSN24458650 482 COSMIC
COSN17181908 526 COSMIC
COSN31606008 597 COSMIC
COSN31514311 635 COSMIC
COSN22990545 641 COSMIC
COSN31571929 667 COSMIC
COSN8552083 698 COSMIC
COSN32158767 703 COSMIC
COSN31561649 761 COSMIC
COSN30137877 763 COSMIC
COSN13780043 781 COSMIC
COSN23860911 781 COSMIC
COSN31584958 797 COSMIC
rs117322896 286 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs371779004 1 dbSNP
rs1172315999 2 dbSNP
rs1346905328 4 dbSNP
rs375448782 10 dbSNP
rs749450046 12 dbSNP
rs1256520123 19 dbSNP
rs771519430 28 dbSNP
rs1165374079 29 dbSNP
rs755177603 33 dbSNP
rs1434185091 40 dbSNP
rs201648143 45 dbSNP
rs746201580 48 dbSNP
rs1232202049 54 dbSNP
rs1310236722 61 dbSNP
rs758259415 68 dbSNP
rs1232800613 72 dbSNP
rs1219479707 74 dbSNP
rs1340198714 75 dbSNP
rs1276325121 80 dbSNP
rs529956507 82 dbSNP
rs1363405788 83 dbSNP
rs1376553378 93 dbSNP
rs1302799772 97 dbSNP
rs1465026429 98 dbSNP
rs1356609617 107 dbSNP
rs777710617 111 dbSNP
rs183368203 114 dbSNP
rs563403021 128 dbSNP
rs939908378 129 dbSNP
rs770722228 132 dbSNP
rs1475918834 133 dbSNP
rs530509784 143 dbSNP
rs1350378595 144 dbSNP
rs1037179035 145 dbSNP
rs919649956 152 dbSNP
rs368824700 153 dbSNP
rs1044014299 154 dbSNP
rs1235162456 157 dbSNP
rs1341118182 159 dbSNP
rs1030222432 164 dbSNP
rs1489937169 177 dbSNP
rs1376237052 178 dbSNP
rs570376354 183 dbSNP
rs1465435332 187 dbSNP
rs1007362413 194 dbSNP
rs1399040253 201 dbSNP
rs755987652 214 dbSNP
rs150906399 221 dbSNP
rs1368540159 228 dbSNP
rs1186303896 229 dbSNP
rs1421929117 240 dbSNP
rs1252587329 243 dbSNP
rs1439655927 245 dbSNP
rs1179547993 248 dbSNP
rs72994216 253 dbSNP
rs1473002889 254 dbSNP
rs1255973345 256 dbSNP
rs1010439299 258 dbSNP
rs78704590 261 dbSNP
rs1215754877 270 dbSNP
rs555161098 272 dbSNP
rs762466606 273 dbSNP
rs996281436 276 dbSNP
rs1319182740 282 dbSNP
rs1310665726 283 dbSNP
rs117322896 286 dbSNP
rs1375114088 290 dbSNP
rs535696022 300 dbSNP
rs1423539476 308 dbSNP
rs926860712 309 dbSNP
rs938296335 310 dbSNP
rs1388141536 313 dbSNP
rs1053954986 314 dbSNP
rs1391024491 317 dbSNP
rs138404339 320 dbSNP
rs187871947 325 dbSNP
rs1042464727 326 dbSNP
rs1159158806 330 dbSNP
rs1327398407 331 dbSNP
rs1019562543 335 dbSNP
rs757795549 337 dbSNP
rs901274420 345 dbSNP
rs961596258 346 dbSNP
rs998160093 348 dbSNP
rs1452343539 357 dbSNP
rs1050200828 367 dbSNP
rs889031946 369 dbSNP
rs539564754 372 dbSNP
rs558202710 374 dbSNP
rs74454158 375 dbSNP
rs550592362 394 dbSNP
rs573166324 405 dbSNP
rs1025997610 413 dbSNP
rs1240012609 418 dbSNP
rs116273286 428 dbSNP
rs931033418 433 dbSNP
rs1306014852 438 dbSNP
rs1234430570 443 dbSNP
rs1331288108 446 dbSNP
rs1245459740 449 dbSNP
rs1322501881 456 dbSNP
rs1384769916 461 dbSNP
rs979852677 462 dbSNP
rs926944884 478 dbSNP
rs79495694 482 dbSNP
rs574764307 494 dbSNP
rs542081237 495 dbSNP
rs1478250642 503 dbSNP
rs1249718246 516 dbSNP
rs1196993680 518 dbSNP
rs892014210 526 dbSNP
rs946293713 535 dbSNP
rs10405375 536 dbSNP
rs1487558800 541 dbSNP
rs1283128205 546 dbSNP
rs1033801884 547 dbSNP
rs546921869 550 dbSNP
rs1443797447 551 dbSNP
rs1230603749 552 dbSNP
rs959630928 560 dbSNP
rs990167177 563 dbSNP
rs1278212039 564 dbSNP
rs530706233 584 dbSNP
rs867886251 585 dbSNP
rs143003329 592 dbSNP
rs766770281 597 dbSNP
rs1415017817 603 dbSNP
rs570636623 604 dbSNP
rs1170661001 630 dbSNP
rs922649586 631 dbSNP
rs1008865206 632 dbSNP
rs564165026 643 dbSNP
rs1476897060 644 dbSNP
rs1259761177 660 dbSNP
rs1015340306 661 dbSNP
rs1442417580 668 dbSNP
rs539211773 677 dbSNP
rs1197940660 680 dbSNP
rs934106437 689 dbSNP
rs1049749753 690 dbSNP
rs1217433395 694 dbSNP
rs1402310973 697 dbSNP
rs1397051965 698 dbSNP
rs1285484817 705 dbSNP
rs1448659662 711 dbSNP
rs889809554 717 dbSNP
rs1339860922 721 dbSNP
rs943287871 730 dbSNP
rs952571805 731 dbSNP
rs1401246536 732 dbSNP
rs1170215525 734 dbSNP
rs979821638 749 dbSNP
rs927081646 751 dbSNP
rs1182582282 763 dbSNP
rs1037553331 767 dbSNP
rs1472724749 771 dbSNP
rs1236234457 772 dbSNP
rs1452420637 779 dbSNP
rs755022786 781 dbSNP
rs10403439 782 dbSNP
rs1238003660 783 dbSNP
rs912909181 788 dbSNP
rs1315745863 808 dbSNP
rs993256266 808 dbSNP
rs1291382326 809 dbSNP
rs1228406110 818 dbSNP
rs546182901 819 dbSNP
rs1355509160 825 dbSNP
rs1026138859 828 dbSNP
rs946292512 830 dbSNP
rs796711276 838 dbSNP
rs1377323818 845 dbSNP
rs1330504049 850 dbSNP
rs1444826161 854 dbSNP
rs904688310 868 dbSNP
rs1165487128 870 dbSNP
rs1404869920 871 dbSNP
rs1345849054 874 dbSNP
rs1160949467 883 dbSNP
rs1412199133 883 dbSNP
rs932172258 886 dbSNP
rs1380068241 900 dbSNP
rs1050590966 902 dbSNP
rs751467787 905 dbSNP
rs369374680 906 dbSNP
rs906278201 917 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ucguccucccGAC-CCGUCCGc 5'
                    ||| ||||||| 
Target 5' ----------CUGAGGCAGGCa 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000304030.2 | 3UTR | CUGAGGCAGGCAGAUCACCUGAGGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-4763-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT116035 DEPDC1 DEP domain containing 1 2 2
MIRT347197 SIN3B SIN3 transcription regulator family member B 2 2
MIRT443248 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT475164 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT495486 VTI1B vesicle transport through interaction with t-SNAREs 1B 2 2
MIRT496755 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT496863 C21orf2 chromosome 21 open reading frame 2 2 2
MIRT499264 NBPF11 NBPF member 11 2 2
MIRT499517 MAFK MAF bZIP transcription factor K 2 2
MIRT512952 MKI67 marker of proliferation Ki-67 2 2
MIRT514656 NUP93 nucleoporin 93 2 2
MIRT517986 SLC16A13 solute carrier family 16 member 13 2 2
MIRT522816 KLHL9 kelch like family member 9 2 4
MIRT525495 CD63 CD63 molecule 2 2
MIRT528111 FOXH1 forkhead box H1 2 2
MIRT531683 MYO3A myosin IIIA 2 2
MIRT534806 RAB37 RAB37, member RAS oncogene family 2 2
MIRT573041 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT576720 Wars tryptophanyl-tRNA synthetase 2 2
MIRT609727 MLXIPL MLX interacting protein like 2 2
MIRT610843 FAM180B family with sequence similarity 180 member B 2 4
MIRT614735 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT616981 EPOR erythropoietin receptor 2 2
MIRT617265 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT619405 INTS7 integrator complex subunit 7 2 2
MIRT621832 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT621893 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT630263 SMIM14 small integral membrane protein 14 2 2
MIRT634879 SENP8 SUMO/sentrin peptidase family member, NEDD8 specific 2 2
MIRT636863 ARSE arylsulfatase E (chondrodysplasia punctata 1) 2 2
MIRT637653 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT637699 ZNF439 zinc finger protein 439 2 2
MIRT637759 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT638193 TAOK1 TAO kinase 1 2 2
MIRT638996 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT642221 RABAC1 Rab acceptor 1 2 2
MIRT643327 ATCAY ATCAY, caytaxin 2 4
MIRT643419 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT644499 RNF14 ring finger protein 14 2 2
MIRT644603 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT644795 C21orf59 chromosome 21 open reading frame 59 2 2
MIRT648732 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT653856 SHE Src homology 2 domain containing E 2 2
MIRT654129 RPL14 ribosomal protein L14 2 4
MIRT658876 DSN1 DSN1 homolog, MIS12 kinetochore complex component 2 2
MIRT671624 C20orf144 chromosome 20 open reading frame 144 2 4
MIRT677367 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT677579 TRIM65 tripartite motif containing 65 2 2
MIRT678220 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT679613 RRP36 ribosomal RNA processing 36 2 2
MIRT686081 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT691817 ICA1L islet cell autoantigen 1 like 2 2
MIRT693869 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT694544 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT694926 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT697758 USP37 ubiquitin specific peptidase 37 2 2
MIRT697891 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT701569 MYPN myopalladin 2 2
MIRT703081 GPRIN3 GPRIN family member 3 2 2
MIRT708104 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT708320 NT5C 5', 3'-nucleotidase, cytosolic 2 2
MIRT709878 TRAF1 TNF receptor associated factor 1 2 2
MIRT713545 GJB1 gap junction protein beta 1 2 2
MIRT716275 NUP85 nucleoporin 85 2 2
MIRT716621 CRCP CGRP receptor component 2 2
MIRT717987 C9orf171 cilia and flagella associated protein 77 2 2
MIRT718438 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT722544 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2 2
MIRT724013 F2RL1 F2R like trypsin receptor 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4763 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Vincristine 5978 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-mir-4763 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4763 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4763-5p Anthracycline 30323 NSC82151 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Fluorouracil 3385 NSC19893 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Cyclophosphamide 2907 NSC26271 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Methotrexate 126941 NSC740 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Taxol 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-miR-4763-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-4763-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4763-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-4763-5p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4763-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4763-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4763-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

Error report submission