miRTarBase - #MIRT638282


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pre-miRNA Information
pre-miRNA hsa-mir-3940   
Genomic Coordinates chr19: 6416410 - 6416511
Description Homo sapiens miR-3940 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-3940-3p
Sequence 57| CAGCCCGGAUCCCAGCCCACUU |78
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN7451488 7 COSMIC
COSN8606686 12 COSMIC
COSN26556646 17 COSMIC
COSN32052209 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1038465553 2 dbSNP
rs779012242 3 dbSNP
rs753266822 4 dbSNP
rs766893050 6 dbSNP
rs1436139782 7 dbSNP
rs1402099476 8 dbSNP
rs1302859978 13 dbSNP
rs759153046 16 dbSNP
rs559739712 19 dbSNP
rs187508006 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SH2B3   
Synonyms IDDM20, LNK
Description SH2B adaptor protein 3
Transcript NM_005475   
Expression
Putative miRNA Targets on SH2B3
3'UTR of SH2B3
(miRNA target sites are highlighted)		 
>SH2B3|NM_005475|3'UTR
   1 CCAGTGAGGAATTCCAGGCCTCAACAGCTGCCCTTGAGGAGCACAGGCAGAAGTGTGAACTTGTGAATGTAATTGATCTT
  81 TCCTTCCTTCCAGAGAAAGATTTAAGGGACACTGTTAACTGCTCGTGCCAGTTTGGAAGTGACCCTTCTATTAGGCCTGT
 161 TGAAGGGCCCTCCTGTAGGTTTCATCTATCCACCTGGCTTTCTCCTTATTGTTTACAGATGTAGTTCTTGTTAGAGGATG
 241 CCGCTAGCTCCTGCCCGGGGTCCCTATGCCCAGTCCCCGTTACTCTTAGAGAAAGGAGTTGGGGTGAGGGCCAGAGCTGG
 321 CAGTGGAAACTTGTTCTCTTTTTCACTGACACTGTCACAGCGGATGACAGACTTTCTACGGGGAGGAGGGGGGGATCATC
 401 AGGAAGCCCAGAACACTAACAAGCGGTTCTCCCATCTACCGTCAGTCCACATGGCAGGTCTGCTGTGTCCACACCACAGA
 481 TGACCACATCTAATCCTGCTTCTACTCTCAGCTTTAGGACAAAAGCTCTGTCAGAGGCACAAGCTGAAGGTCAAAAATGA
 561 TTTAAAACATTTTACCTCAGACTAATTTCTTTAAAGGATTCAGGTTCAAAACTTAACCACTGCTTATTTCAGTGCACTGT
 641 TTCAACTAACACCCATGCTATTTTTGTAGTCAGAAACAGCTATGCAAACCCTACCTAATTTACAGTCTGAGCCAGCATGC
 721 TGGCTTGTCTACTGCATCCTCGGGACAGTCACCTGCCACTGAGTGGCCACTGTCCTTCCTAAATGTCAAGAAGTGAAGTA
 801 TGTCACCCTTTCAGGGAAATTCAGGCAATTACTGAAATAGGAGGGTGGCAAGAACAGTTCTATCCTGGTGCCTTACGAAT
 881 AAAAAACTGGATTCTGGTTTACAGCAGCTTTACAGTGATAGTTAAATTAACTGGGGCTAGGGGAAGAGCAAGCAAAAAGG
 961 GAAGAAGGACTCCTAGGCCCTTTCTAGTAAATCCTTCAGCAACAAGGCTGGCTTGGTGCCCTCCAAGCATCTAATGGCTT
1041 ATTAAATTATCCCACAAGTGGGTTTTAGGCTCCTTTTTTGAGCCAAAATGGAAGCTGGGAATCTGGTGCCATAACTAATG
1121 AGAAACTCCTTTAATAGCCCACAATCAGTGTTCTGTTCTAGCTGGCTACTGCTTCACTGGATTGAGAATCTATCTATCTC
1201 CTTGCACACATGGGCACACACAATCTCCACCATCCAGGGAGGTCCTGAAGTCAAATCTCTATCTATACAAGTGATACAAT
1281 TCATAGGGGGCTGGCTCCTCCCAGAACCTGTCTGGAGGCTCAGAAACGGGGGCAGTGACAGTGGAGTCAGCTGCTCTTGG
1361 GTGCCAGCAGAGCCATTCAGTACAACCCCCAGGCTCACAGCAGTGGCTTCTAGGAAACTGGGAGTTTAGATCAGCTTTAC
1441 AGATACATCGATCAGAGGCTAAAATGAAACCTCAGCCTAAAACTCATAGGACTGACTGCCTGGGAGGAGGGTTAGGTCTG
1521 CTTCTTCCACTTATACTTAGTCTCTGTGCTCCAAGAGGTCAAATTTTTGCTTCTAGAATTTCCTTGGGGTCTTTCAGAGG
1601 GTGGGGGAACAAACCCCTATGCACTTTTCTTTTTTTTTTTTTTGAGATGGAGTTTCTCTTGTCAACCGGGCTGGAGTGCA
1681 GTGGTGCAATCTTGGCTCACTGCAACCTCCACCTTCCTGGTTCAAGCGATTCTGCCTCGACCTCTCAAGTAGCTGGGATT
1761 ACAAGCACCAGCCACCATGCCTGGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGGTCTC
1841 GAATGTCTGACCTCAGGTGATCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGCGAGCCACCGCGCCCAGCC
1921 TACACCACTTTTAGTACCAACACTCTTGGGTGATTTCATGGACCCTAAAGCAGACCTGACACTGATCCAGATTTGCAGTC
2001 CATTTTTAAGGACACCTGTCTTTATTTCCTCAAAGTCAAGCAGCTTTCTCTGGAAAATGAATGCTAATTAGTGTGAACCA
2081 AAAGAGTAAGTAAGAGTCTGAAGTTTTTTTAAAGGAGAAAGCTTATTATGGAAAGTCACTGGTCCTCCCCTCCGCACAGG
2161 AAAGGTACCCAGTAGATAATGAACCAAATTAAGTTCCCTCCCTCCAGCCAGAAGTTAAACATCTGGGATATGACGTCTTC
2241 ATGCCAGGGGCACTCATTTCTTAGCAGCCTCTCTACATACATCTCTCAGGTGGTGCCAAGAGGCACACCAGGTAGAGCAA
2321 ACTTAGCAGCTCTGACTAACAGGCTGCAAAGTGCAAGTTCAGATTCTGTGGCAGAGATTTGGAAGGCACCCACCTCCAGA
2401 CTGCTTCCCGTCCAAGTTACCAGGACAGCTCAAAAACATGCTGACAGAAAACTCCCATGGCTCTAGGAAGAAGTGACACT
2481 AAGCCAACACCTTTCTTTATGTGGGAGCAGAATCAGCTGATGAAGGGGTGGGCAGCAGTGTGGGGCAGGCACCCCACTGG
2561 CTGCAGCTAGCCCACCATAGGCACAGCACATCCCACCACTCTCCTTCCAGTCCTGACCAGGCCCCAGCCGGCAACTTCTA
2641 CCGAGAGCCATGGCTCAACACCAAACTGGACAGTAGACATCATGATCCCTCCAGTTAGCTCTAATTACAGACCCCACCAG
2721 TACAGCTTGACAGCTCCCGGCACCATCCCTTCCTTCATCTGACTTATTGAACTTTTACAAACTAACAGTCACCAGCACCA
2801 AAGAATTAAGTCAACTAACCTGCCTTGAATTTTAGACCAGCAATCCATATGGCTTTATCTGGTATAAATCTTCTGCCTTT
2881 GATCATTTCTGGACCGTAGGAAAAAGGAATAGCAATCATTAAAATCTTGGGCCAGAGAACACTATTTTTACATAACAGTT
2961 TCTTAACCTAAAGTCAAGGCCTTGGACTCTTCCCTGAGGGTTGCCTGAGATTCCTTCATGCTTTCTATTCAGGACTAAGT
3041 CCCTTACTGCAAATGTGTTAGCTCTAACATCTCCCACAAGCTAGAGGAACTTGCGAGTATATTAACAAGGACACATCTGA
3121 CATCCTGTGTTTGGTTAGAATATACAGCACATTGTGATAACATAAAGTGGATTCATCTTGTATCATTATAGGCAGAAGGT
3201 ATTTGGCAAATTTTTATGTATTGTTTTATGTACTGTACAAGTAACTTATTCTTGAATAATGCAAATTTTGCTATAATGTA
3281 CAAATTGCTATATGTGAATTAAAAAGTTTTCAGAATCTTGAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uucacccGACCCUAGGCCCGAc 5'
                 :||  | ||||||| 
Target 5' gtttctcTTGTCAACCGGGCTg 3'
 1652 - 1673 147.00 -17.90
2 
miRNA  3' uucaccCGACCCUAGGCCCGAc 5'
                |:|||   || |||| 
Target 5' caccatGTTGG---CCAGGCTg 3'
 1817 - 1835 117.00 -14.80
3 
miRNA  3' uuCACCCGACCCUAGGCCCGAc 5'
            ||||  ||  |||: |||| 
Target 5' caGTGG--TGCAATCTTGGCTc 3'
 1679 - 1698 116.00 -14.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30128398 21 COSMIC
COSN5930390 38 COSMIC
COSN30161380 163 COSMIC
COSN23188513 177 COSMIC
COSN31483931 231 COSMIC
COSN31524163 477 COSMIC
COSN31565701 577 COSMIC
COSN31534733 590 COSMIC
COSN26585440 670 COSMIC
COSN23134008 689 COSMIC
COSN25007238 742 COSMIC
COSN31481248 749 COSMIC
COSN15109250 845 COSMIC
COSN1557385 952 COSMIC
COSN1557387 1108 COSMIC
COSN16962294 1211 COSMIC
COSN20770258 1316 COSMIC
COSN1557389 1380 COSMIC
COSN5930392 1790 COSMIC
COSN22846143 1880 COSMIC
COSN5930393 2593 COSMIC
COSN31537631 2622 COSMIC
COSN28750063 2740 COSMIC
COSN8694800 2793 COSMIC
COSN31561927 2977 COSMIC
COSN30540839 3193 COSMIC
COSN16479922 3264 COSMIC
COSN31519441 3305 COSMIC
rs11065904 862 GWAS
rs739496 1554 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1471634898 9 dbSNP
rs1481812093 10 dbSNP
rs1161551036 12 dbSNP
rs377181271 15 dbSNP
rs1461135012 16 dbSNP
rs1282030310 21 dbSNP
rs1291507300 23 dbSNP
rs756052069 24 dbSNP
rs369856750 25 dbSNP
rs371026061 27 dbSNP
rs1348598316 28 dbSNP
rs1402540550 29 dbSNP
rs770443581 33 dbSNP
rs778472777 34 dbSNP
rs1203968552 35 dbSNP
rs1291114332 36 dbSNP
rs553582838 36 dbSNP
rs1333625147 40 dbSNP
rs1242162799 43 dbSNP
rs373432208 49 dbSNP
rs755738161 51 dbSNP
rs748102313 53 dbSNP
rs1401685058 54 dbSNP
rs1454809707 55 dbSNP
rs568409579 58 dbSNP
rs1344926106 62 dbSNP
rs1157416706 64 dbSNP
rs780665984 67 dbSNP
rs535118530 70 dbSNP
rs1471039677 71 dbSNP
rs1278594171 93 dbSNP
rs1049488267 106 dbSNP
rs1479494453 108 dbSNP
rs1339817645 113 dbSNP
rs889579808 115 dbSNP
rs1046139940 121 dbSNP
rs1187011242 122 dbSNP
rs902688303 125 dbSNP
rs1257869501 126 dbSNP
rs1032646100 130 dbSNP
rs756801823 131 dbSNP
rs1262119062 137 dbSNP
rs1345752790 146 dbSNP
rs891473879 149 dbSNP
rs999731965 150 dbSNP
rs1295701600 153 dbSNP
rs1383229106 173 dbSNP
rs1200111323 174 dbSNP
rs538454345 176 dbSNP
rs1107853 179 dbSNP
rs958336209 180 dbSNP
rs1024671375 186 dbSNP
rs1489384033 187 dbSNP
rs575021701 188 dbSNP
rs185191334 190 dbSNP
rs1407383968 192 dbSNP
rs1336281984 197 dbSNP
rs1028961532 206 dbSNP
rs979942773 210 dbSNP
rs113141771 211 dbSNP
rs1374812295 212 dbSNP
rs1171256901 221 dbSNP
rs1262878885 221 dbSNP
rs1033715501 222 dbSNP
rs1417285795 225 dbSNP
rs1185416853 226 dbSNP
rs1461581272 233 dbSNP
rs959413698 233 dbSNP
rs1201336610 237 dbSNP
rs750133788 243 dbSNP
rs1226075463 244 dbSNP
rs1305316326 257 dbSNP
rs557680103 258 dbSNP
rs1248851805 269 dbSNP
rs1383956897 275 dbSNP
rs1336508761 276 dbSNP
rs1394468017 277 dbSNP
rs907920116 279 dbSNP
rs1171481624 280 dbSNP
rs754159273 286 dbSNP
rs1368838358 295 dbSNP
rs1165372139 298 dbSNP
rs922869125 299 dbSNP
rs934145430 300 dbSNP
rs1420443404 301 dbSNP
rs1250778856 302 dbSNP
rs779834872 312 dbSNP
rs972631556 314 dbSNP
rs1049956308 343 dbSNP
rs911402256 351 dbSNP
rs935712182 354 dbSNP
rs919737008 355 dbSNP
rs1479353423 356 dbSNP
rs931248098 362 dbSNP
rs746840999 363 dbSNP
rs755477425 379 dbSNP
rs1428093298 380 dbSNP
rs1010340805 381 dbSNP
rs1337976298 385 dbSNP
rs948998245 387 dbSNP
rs1045645447 388 dbSNP
rs1307944003 388 dbSNP
rs369369092 388 dbSNP
rs902299127 389 dbSNP
rs935053955 391 dbSNP
rs1053983313 395 dbSNP
rs747838274 395 dbSNP
rs1364205898 401 dbSNP
rs1339557422 403 dbSNP
rs893946287 404 dbSNP
rs1380483995 406 dbSNP
rs572949540 421 dbSNP
rs540054222 424 dbSNP
rs868289205 425 dbSNP
rs144008428 426 dbSNP
rs1291689401 440 dbSNP
rs189900072 441 dbSNP
rs542272842 442 dbSNP
rs1353265059 448 dbSNP
rs1015339005 452 dbSNP
rs879040602 458 dbSNP
rs35387449 460 dbSNP
rs962176252 461 dbSNP
rs1348870269 471 dbSNP
rs961385007 482 dbSNP
rs973183765 486 dbSNP
rs1405615180 494 dbSNP
rs922841919 495 dbSNP
rs1356167898 496 dbSNP
rs1383901707 505 dbSNP
rs1385335430 505 dbSNP
rs1157811215 513 dbSNP
rs973882823 518 dbSNP
rs1026833482 520 dbSNP
rs1176798087 526 dbSNP
rs1479807991 528 dbSNP
rs1285777858 529 dbSNP
rs955575364 531 dbSNP
rs1485063877 533 dbSNP
rs985714008 535 dbSNP
rs1208513775 539 dbSNP
rs1327599271 543 dbSNP
rs911362992 547 dbSNP
rs936183269 550 dbSNP
rs182413950 560 dbSNP
rs990742435 572 dbSNP
rs1192508758 576 dbSNP
rs1273177071 583 dbSNP
rs1229463122 585 dbSNP
rs1326954068 586 dbSNP
rs1432615980 590 dbSNP
rs1408081129 595 dbSNP
rs531042241 598 dbSNP
rs146709278 604 dbSNP
rs1158832608 618 dbSNP
rs1359664053 627 dbSNP
rs1476642715 629 dbSNP
rs1451280031 641 dbSNP
rs570960086 644 dbSNP
rs1463798446 646 dbSNP
rs1245408815 648 dbSNP
rs1391419122 651 dbSNP
rs981823503 672 dbSNP
rs768569883 680 dbSNP
rs1379158641 684 dbSNP
rs1216413301 686 dbSNP
rs1340216035 688 dbSNP
rs781249676 690 dbSNP
rs1226158385 691 dbSNP
rs935108498 702 dbSNP
rs1053922056 712 dbSNP
rs1384667737 716 dbSNP
rs893977611 721 dbSNP
rs932119053 722 dbSNP
rs1308726809 723 dbSNP
rs906878972 724 dbSNP
rs1330545011 733 dbSNP
rs1247526147 734 dbSNP
rs1266370885 737 dbSNP
rs1395194047 742 dbSNP
rs1050546432 743 dbSNP
rs989079069 752 dbSNP
rs890747911 757 dbSNP
rs1212309249 767 dbSNP
rs887600561 771 dbSNP
rs1009547791 779 dbSNP
rs1014957293 783 dbSNP
rs1235929733 785 dbSNP
rs1006493333 791 dbSNP
rs1458661570 807 dbSNP
rs1178875504 815 dbSNP
rs138726800 816 dbSNP
rs961794339 821 dbSNP
rs546867378 822 dbSNP
rs1227519535 839 dbSNP
rs1416911967 840 dbSNP
rs1166720704 842 dbSNP
rs1368781970 847 dbSNP
rs994272110 853 dbSNP
rs1457375051 856 dbSNP
rs1323735740 857 dbSNP
rs11065904 862 dbSNP
rs955369832 863 dbSNP
rs1305671870 867 dbSNP
rs1406899285 875 dbSNP
rs1447686618 875 dbSNP
rs958768861 877 dbSNP
rs535723853 878 dbSNP
rs142747203 887 dbSNP
rs990688567 895 dbSNP
rs1405133853 896 dbSNP
rs377666881 897 dbSNP
rs568475255 899 dbSNP
rs1412144976 906 dbSNP
rs1023452356 913 dbSNP
rs1470655035 914 dbSNP
rs1251092772 916 dbSNP
rs1180127081 918 dbSNP
rs539165284 920 dbSNP
rs1490877923 921 dbSNP
rs985696178 932 dbSNP
rs1018561017 937 dbSNP
rs1220797294 939 dbSNP
rs970661120 944 dbSNP
rs1397981945 947 dbSNP
rs1313909842 949 dbSNP
rs1321454159 950 dbSNP
rs1286110537 952 dbSNP
rs1231999771 953 dbSNP
rs1260483142 954 dbSNP
rs538311693 961 dbSNP
rs1406227807 969 dbSNP
rs557882907 988 dbSNP
rs1345664968 996 dbSNP
rs923647766 997 dbSNP
rs144467643 998 dbSNP
rs934951196 1000 dbSNP
rs1304245745 1007 dbSNP
rs913406538 1017 dbSNP
rs945745905 1025 dbSNP
rs1231797719 1026 dbSNP
rs1161746302 1030 dbSNP
rs1401448675 1044 dbSNP
rs981173907 1047 dbSNP
rs928275928 1048 dbSNP
rs1479468812 1062 dbSNP
rs1269751944 1074 dbSNP
rs1190502442 1075 dbSNP
rs989254700 1082 dbSNP
rs1487482315 1101 dbSNP
rs760032233 1101 dbSNP
rs1243565498 1112 dbSNP
rs915027469 1112 dbSNP
rs1464317101 1124 dbSNP
rs1183200521 1126 dbSNP
rs937039000 1128 dbSNP
rs540455114 1136 dbSNP
rs1225006658 1138 dbSNP
rs1323562072 1141 dbSNP
rs931730340 1145 dbSNP
rs1050577941 1147 dbSNP
rs1219091515 1148 dbSNP
rs887737778 1152 dbSNP
rs1291206138 1160 dbSNP
rs1436273854 1161 dbSNP
rs912050186 1163 dbSNP
rs941866816 1165 dbSNP
rs944993598 1170 dbSNP
rs1036999914 1176 dbSNP
rs1318762707 1183 dbSNP
rs1256603194 1184 dbSNP
rs1471090304 1187 dbSNP
rs1175456990 1188 dbSNP
rs1430026074 1188 dbSNP
rs1036571320 1192 dbSNP
rs1421550077 1193 dbSNP
rs555120148 1196 dbSNP
rs1162514704 1197 dbSNP
rs1425772492 1199 dbSNP
rs1466047107 1202 dbSNP
rs1270102792 1203 dbSNP
rs147975549 1209 dbSNP
rs187076978 1210 dbSNP
rs1029780585 1216 dbSNP
rs894585004 1222 dbSNP
rs1012990683 1237 dbSNP
rs1308817934 1238 dbSNP
rs1298333598 1246 dbSNP
rs773116171 1249 dbSNP
rs1364861434 1256 dbSNP
rs369388169 1257 dbSNP
rs1003464290 1258 dbSNP
rs143559288 1258 dbSNP
rs369782119 1258 dbSNP
rs762998039 1259 dbSNP
rs563680575 1260 dbSNP
rs956642205 1261 dbSNP
rs1020846762 1262 dbSNP
rs1448826416 1267 dbSNP
rs967583934 1269 dbSNP
rs1185216755 1272 dbSNP
rs1445080910 1278 dbSNP
rs981145905 1281 dbSNP
rs1179797027 1286 dbSNP
rs989590850 1290 dbSNP
rs530879942 1294 dbSNP
rs1341735594 1297 dbSNP
rs937007992 1305 dbSNP
rs991150402 1328 dbSNP
rs908886684 1329 dbSNP
rs914891576 1331 dbSNP
rs1272859627 1337 dbSNP
rs545874198 1345 dbSNP
rs774547449 1347 dbSNP
rs941903685 1348 dbSNP
rs985816864 1354 dbSNP
rs1036301958 1357 dbSNP
rs11551805 1358 dbSNP
rs1308721115 1370 dbSNP
rs897638940 1375 dbSNP
rs1485138168 1382 dbSNP
rs759948757 1382 dbSNP
rs866206340 1384 dbSNP
rs1368622507 1393 dbSNP
rs564642150 1399 dbSNP
rs1458193282 1405 dbSNP
rs1367730206 1406 dbSNP
rs1185580852 1410 dbSNP
rs1162204469 1416 dbSNP
rs1420538927 1420 dbSNP
rs933162762 1424 dbSNP
rs1180842190 1426 dbSNP
rs912081662 1428 dbSNP
rs1481820149 1441 dbSNP
rs528559792 1441 dbSNP
rs1478119050 1443 dbSNP
rs944833327 1447 dbSNP
rs1036522996 1448 dbSNP
rs547198985 1450 dbSNP
rs1018246533 1451 dbSNP
rs1318972058 1454 dbSNP
rs919539714 1457 dbSNP
rs930890417 1458 dbSNP
rs73410519 1467 dbSNP
rs1012212675 1476 dbSNP
rs1020565690 1483 dbSNP
rs1387306364 1486 dbSNP
rs753256301 1488 dbSNP
rs1176857768 1490 dbSNP
rs967934019 1490 dbSNP
rs1013023587 1491 dbSNP
rs1045805941 1496 dbSNP
rs1158043717 1498 dbSNP
rs1375134773 1502 dbSNP
rs1003038040 1503 dbSNP
rs1035396415 1505 dbSNP
rs906373385 1510 dbSNP
rs1267042709 1511 dbSNP
rs1208418335 1519 dbSNP
rs1487093647 1520 dbSNP
rs567184089 1528 dbSNP
rs1228070791 1529 dbSNP
rs1300461405 1529 dbSNP
rs529554767 1535 dbSNP
rs1233802144 1539 dbSNP
rs1330460091 1541 dbSNP
rs34113226 1548 dbSNP
rs1321570055 1552 dbSNP
rs1003821531 1553 dbSNP
rs739496 1554 dbSNP
rs956860224 1558 dbSNP
rs554158942 1563 dbSNP
rs1455336449 1564 dbSNP
rs991202814 1573 dbSNP
rs1399940900 1574 dbSNP
rs1477443730 1575 dbSNP
rs1377554884 1576 dbSNP
rs1197421967 1578 dbSNP
rs370221223 1585 dbSNP
rs775617082 1589 dbSNP
rs1370347264 1603 dbSNP
rs1208305294 1608 dbSNP
rs953028442 1617 dbSNP
rs963090134 1620 dbSNP
rs972372483 1624 dbSNP
rs1272966268 1625 dbSNP
rs1344481475 1625 dbSNP
rs1229584435 1626 dbSNP
rs1346764179 1628 dbSNP
rs1452431657 1629 dbSNP
rs1171290536 1630 dbSNP
rs1296635916 1630 dbSNP
rs1399497256 1630 dbSNP
rs1432354262 1630 dbSNP
rs1208218574 1631 dbSNP
rs1391101785 1633 dbSNP
rs1188345011 1634 dbSNP
rs192795591 1635 dbSNP
rs1488455184 1644 dbSNP
rs75098846 1644 dbSNP
rs78411582 1645 dbSNP
rs1188552026 1648 dbSNP
rs974461567 1652 dbSNP
rs1214996941 1659 dbSNP
rs1240340703 1664 dbSNP
rs933131675 1666 dbSNP
rs551075499 1668 dbSNP
rs373527498 1669 dbSNP
rs1478964062 1673 dbSNP
rs1191883512 1676 dbSNP
rs1225897324 1677 dbSNP
rs1384776805 1687 dbSNP
rs577512562 1699 dbSNP
rs1284402241 1701 dbSNP
rs1394509396 1702 dbSNP
rs1338154642 1703 dbSNP
rs1051562985 1704 dbSNP
rs566947116 1713 dbSNP
rs972664435 1714 dbSNP
rs1452847003 1726 dbSNP
rs141807085 1728 dbSNP
rs533625506 1729 dbSNP
rs1428181697 1733 dbSNP
rs1400553149 1736 dbSNP
rs1416468981 1740 dbSNP
rs930901559 1744 dbSNP
rs1164000760 1749 dbSNP
rs1316677132 1761 dbSNP
rs555616591 1763 dbSNP
rs1472609511 1769 dbSNP
rs1235739542 1779 dbSNP
rs1184452376 1782 dbSNP
rs1039801966 1785 dbSNP
rs893112561 1788 dbSNP
rs1437778630 1808 dbSNP
rs1323237846 1810 dbSNP
rs1326021704 1811 dbSNP
rs985018011 1820 dbSNP
rs1011601957 1823 dbSNP
rs12318170 1841 dbSNP
rs948665443 1842 dbSNP
rs1003090471 1846 dbSNP
rs11065905 1869 dbSNP
rs907321239 1872 dbSNP
rs201621186 1873 dbSNP
rs374257949 1875 dbSNP
rs143381779 1901 dbSNP
rs577850132 1902 dbSNP
rs183619523 1903 dbSNP
rs1161702247 1906 dbSNP
rs768731398 1911 dbSNP
rs780808994 1912 dbSNP
rs564298450 1913 dbSNP
rs1467149506 1914 dbSNP
rs748137324 1926 dbSNP
rs1449719449 1936 dbSNP
rs761656038 1941 dbSNP
rs1239091193 1942 dbSNP
rs1327808189 1943 dbSNP
rs1285948500 1944 dbSNP
rs769667961 1949 dbSNP
rs146230476 1959 dbSNP
rs918923613 1960 dbSNP
rs540293964 1982 dbSNP
rs777734730 1993 dbSNP
rs561951589 1996 dbSNP
rs28698441 2009 dbSNP
rs943211604 2019 dbSNP
rs529493274 2022 dbSNP
rs749434010 2024 dbSNP
rs1387919651 2037 dbSNP
rs767098900 2042 dbSNP
rs914702440 2043 dbSNP
rs1425784825 2046 dbSNP
rs1190585250 2049 dbSNP
rs971809229 2050 dbSNP
rs947367249 2063 dbSNP
rs1164750385 2065 dbSNP
rs550755413 2069 dbSNP
rs1041685467 2073 dbSNP
rs1265631792 2080 dbSNP
rs1026917176 2083 dbSNP
rs1312307388 2084 dbSNP
rs903197435 2085 dbSNP
rs1369185047 2087 dbSNP
rs367587742 2087 dbSNP
rs1003057920 2092 dbSNP
rs770981060 2092 dbSNP
rs1436021077 2097 dbSNP
rs1364719956 2099 dbSNP
rs1287410054 2100 dbSNP
rs1467618168 2101 dbSNP
rs1057330593 2104 dbSNP
rs1175206632 2110 dbSNP
rs894635973 2118 dbSNP
rs116471213 2121 dbSNP
rs1188988217 2127 dbSNP
rs1016417458 2132 dbSNP
rs774567596 2154 dbSNP
rs916198578 2155 dbSNP
rs948948477 2158 dbSNP
rs1272535016 2160 dbSNP
rs1209951133 2164 dbSNP
rs1332585160 2166 dbSNP
rs1200645842 2170 dbSNP
rs981464823 2176 dbSNP
rs1238844332 2178 dbSNP
rs533438265 2190 dbSNP
rs1179873954 2199 dbSNP
rs1341949833 2208 dbSNP
rs987371898 2212 dbSNP
rs1239582699 2222 dbSNP
rs1398026355 2231 dbSNP
rs1017555220 2235 dbSNP
rs746019888 2236 dbSNP
rs143689410 2238 dbSNP
rs1053189270 2241 dbSNP
rs989363443 2247 dbSNP
rs892299040 2256 dbSNP
rs915067576 2266 dbSNP
rs1166420183 2274 dbSNP
rs946520780 2274 dbSNP
rs1424034853 2283 dbSNP
rs1396545917 2286 dbSNP
rs1254799065 2293 dbSNP
rs947458182 2295 dbSNP
rs1409020719 2305 dbSNP
rs1254557233 2309 dbSNP
rs1043534249 2318 dbSNP
rs1206561163 2321 dbSNP
rs977930137 2327 dbSNP
rs188390108 2331 dbSNP
rs147930688 2332 dbSNP
rs1322567092 2333 dbSNP
rs533896620 2336 dbSNP
rs1415240107 2341 dbSNP
rs1231523326 2345 dbSNP
rs1352448873 2346 dbSNP
rs879072670 2347 dbSNP
rs879050060 2348 dbSNP
rs1292417336 2349 dbSNP
rs1057312330 2354 dbSNP
rs549051968 2361 dbSNP
rs1007416242 2386 dbSNP
rs894763475 2390 dbSNP
rs772520765 2393 dbSNP
rs1044699 2395 dbSNP
rs948992502 2402 dbSNP
rs193226463 2408 dbSNP
rs1019037880 2410 dbSNP
rs538078078 2411 dbSNP
rs1026097165 2416 dbSNP
rs1183480320 2417 dbSNP
rs993655733 2430 dbSNP
rs1026029629 2440 dbSNP
rs11065906 2451 dbSNP
rs984995343 2457 dbSNP
rs764553430 2459 dbSNP
rs1023122037 2461 dbSNP
rs184763610 2462 dbSNP
rs1211988250 2472 dbSNP
rs760347241 2474 dbSNP
rs970328645 2488 dbSNP
rs1210662551 2489 dbSNP
rs570524985 2491 dbSNP
rs765946130 2495 dbSNP
rs1331276317 2496 dbSNP
rs115820824 2508 dbSNP
rs1373168776 2513 dbSNP
rs1333897101 2525 dbSNP
rs1474830137 2525 dbSNP
rs956029061 2529 dbSNP
rs989311303 2533 dbSNP
rs1022108516 2542 dbSNP
rs1403958588 2544 dbSNP
rs1387110545 2546 dbSNP
rs1389811634 2549 dbSNP
rs1323415818 2553 dbSNP
rs111599881 2554 dbSNP
rs1388641180 2555 dbSNP
rs1157785201 2556 dbSNP
rs1468205992 2562 dbSNP
rs1362562402 2571 dbSNP
rs1434925667 2576 dbSNP
rs1434099297 2578 dbSNP
rs777273710 2579 dbSNP
rs1191909887 2588 dbSNP
rs977522327 2595 dbSNP
rs1373349206 2598 dbSNP
rs1208185131 2605 dbSNP
rs1348686287 2607 dbSNP
rs1257672237 2608 dbSNP
rs947454462 2614 dbSNP
rs1043568401 2616 dbSNP
rs1330254191 2629 dbSNP
rs1296135094 2630 dbSNP
rs910355030 2631 dbSNP
rs1365453442 2642 dbSNP
rs1319552706 2643 dbSNP
rs992752628 2644 dbSNP
rs1403780710 2651 dbSNP
rs1225416705 2664 dbSNP
rs760620571 2675 dbSNP
rs943305519 2677 dbSNP
rs1451799350 2685 dbSNP
rs1248849620 2686 dbSNP
rs1348925769 2690 dbSNP
rs1192814398 2696 dbSNP
rs1445309238 2697 dbSNP
rs948972862 2698 dbSNP
rs1278643233 2700 dbSNP
rs1200895208 2702 dbSNP
rs144152836 2703 dbSNP
rs1206077682 2706 dbSNP
rs1261724432 2710 dbSNP
rs1445746113 2713 dbSNP
rs1230328976 2714 dbSNP
rs765931294 2718 dbSNP
rs1342657324 2724 dbSNP
rs573110400 2727 dbSNP
rs1378814178 2738 dbSNP
rs148924662 2739 dbSNP
rs1172557145 2740 dbSNP
rs1047846495 2751 dbSNP
rs1047508477 2753 dbSNP
rs189463848 2758 dbSNP
rs1005962635 2759 dbSNP
rs573783465 2760 dbSNP
rs1008660316 2761 dbSNP
rs191201994 2768 dbSNP
rs1325629593 2779 dbSNP
rs1371763112 2780 dbSNP
rs1406482166 2781 dbSNP
rs1233866747 2784 dbSNP
rs529632556 2785 dbSNP
rs1485422357 2787 dbSNP
rs142759669 2797 dbSNP
rs1003541612 2823 dbSNP
rs1356121890 2826 dbSNP
rs1483232184 2830 dbSNP
rs1240259583 2837 dbSNP
rs1260483442 2838 dbSNP
rs1284494022 2846 dbSNP
rs1349191768 2846 dbSNP
rs1212112756 2847 dbSNP
rs533694963 2859 dbSNP
rs900187649 2860 dbSNP
rs767176467 2865 dbSNP
rs956482642 2866 dbSNP
rs1254337432 2869 dbSNP
rs1328614261 2872 dbSNP
rs1468490889 2876 dbSNP
rs1192450828 2880 dbSNP
rs1408626898 2891 dbSNP
rs1416221216 2895 dbSNP
rs988869130 2896 dbSNP
rs1164090615 2897 dbSNP
rs914559573 2906 dbSNP
rs1474907408 2910 dbSNP
rs1420467989 2911 dbSNP
rs551748505 2916 dbSNP
rs985483263 2923 dbSNP
rs1415799069 2925 dbSNP
rs183800991 2928 dbSNP
rs1472885752 2932 dbSNP
rs752474941 2935 dbSNP
rs943182976 2936 dbSNP
rs1453154192 2949 dbSNP
rs1022664438 2953 dbSNP
rs1362957287 2954 dbSNP
rs755929482 2958 dbSNP
rs1230711377 2965 dbSNP
rs1164870586 2969 dbSNP
rs999348016 2978 dbSNP
rs151122209 2979 dbSNP
rs1352029961 2980 dbSNP
rs1034823034 2982 dbSNP
rs960073074 2988 dbSNP
rs1392294457 2990 dbSNP
rs1161444322 2993 dbSNP
rs142590304 2995 dbSNP
rs1323941427 2996 dbSNP
rs1379458730 2997 dbSNP
rs1392130846 2999 dbSNP
rs548988953 3001 dbSNP
rs567403911 3005 dbSNP
rs146851466 3019 dbSNP
rs1247642081 3020 dbSNP
rs1047420364 3028 dbSNP
rs1274411685 3034 dbSNP
rs1247103698 3050 dbSNP
rs887414317 3062 dbSNP
rs970491305 3083 dbSNP
rs546237112 3085 dbSNP
rs560167415 3088 dbSNP
rs906041236 3095 dbSNP
rs751078293 3096 dbSNP
rs1222583570 3097 dbSNP
rs1481421319 3098 dbSNP
rs1177382444 3100 dbSNP
rs1249559492 3106 dbSNP
rs1003078380 3111 dbSNP
rs1417146766 3113 dbSNP
rs1036267443 3118 dbSNP
rs1189797159 3119 dbSNP
rs117652846 3127 dbSNP
rs796944149 3128 dbSNP
rs188518820 3137 dbSNP
rs749162977 3141 dbSNP
rs541748368 3142 dbSNP
rs1416111480 3145 dbSNP
rs944415689 3146 dbSNP
rs1402502593 3151 dbSNP
rs1452412333 3156 dbSNP
rs985517393 3159 dbSNP
rs1018347570 3164 dbSNP
rs1188857428 3168 dbSNP
rs1038818009 3169 dbSNP
rs1297764012 3175 dbSNP
rs1239890730 3190 dbSNP
rs1214189552 3191 dbSNP
rs965841026 3195 dbSNP
rs1281750023 3207 dbSNP
rs1398225665 3210 dbSNP
rs14555 3211 dbSNP
rs923084968 3218 dbSNP
rs1300038332 3221 dbSNP
rs1346229178 3221 dbSNP
rs778926718 3230 dbSNP
rs1361284059 3231 dbSNP
rs1287209925 3261 dbSNP
rs538932158 3262 dbSNP
rs553830246 3263 dbSNP
rs1432603856 3265 dbSNP
rs565957592 3271 dbSNP
rs908880717 3272 dbSNP
rs1427559206 3273 dbSNP
rs941644897 3281 dbSNP
rs1034790565 3283 dbSNP
rs1483314433 3291 dbSNP
rs960538709 3293 dbSNP
rs1210828783 3303 dbSNP
rs1044080319 3304 dbSNP
rs746126135 3309 dbSNP
rs1014279271 3317 dbSNP
rs1257907871 3318 dbSNP
rs1228359455 3320 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uucacccgacccUAGGCCCGAc 5'
                      | ||||||| 
Target 5' ------------AACCGGGCUg 3'
 		1 - 10
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000341259.2 | 3UTR | AACCGGGCUGGAGUGCAGUGGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000341259.2 | 3UTR | AACCGGGCUGGAGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.473 0.01 -0.315 0.06 26 Click to see details
BRCA -0.256 0.08 -0.189 0.15 33 Click to see details
ESCA -0.822 0.09 -0.600 0.2 4 Click to see details
PRAD -0.557 0.13 -0.029 0.48 6 Click to see details
KICH 0.358 0.13 0.147 0.32 12 Click to see details
KIRC 0.228 0.17 0.200 0.21 19 Click to see details
BLCA 0.371 0.18 0.381 0.18 8 Click to see details
LIHC 0.088 0.3 0.112 0.25 38 Click to see details
UCEC -0.169 0.31 -0.109 0.37 11 Click to see details
KIRP 0.151 0.31 0.148 0.31 13 Click to see details
THCA -0.045 0.39 -0.082 0.3 43 Click to see details
HNSC -0.068 0.4 -0.047 0.43 17 Click to see details
LUAD -0.054 0.45 0.024 0.48 8 Click to see details
CHOL 0.06 0.47 0.000 0.5 4 Click to see details
STAD -0.019 0.48 -0.250 0.26 9 Click to see details
STAD -0.019 0.48 -0.250 0.26 9 Click to see details
STAD -0.019 0.48 -0.250 0.26 9 Click to see details
STAD -0.019 0.48 -0.250 0.26 9 Click to see details
STAD -0.019 0.48 -0.250 0.26 9 Click to see details
42 hsa-miR-3940-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118010 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 6
MIRT268170 POU2F1 POU class 2 homeobox 1 2 2
MIRT289461 BIRC5 baculoviral IAP repeat containing 5 2 4
MIRT409766 HRH2 histamine receptor H2 2 2
MIRT452070 ZNF585B zinc finger protein 585B 2 8
MIRT458519 GSG2 histone H3 associated protein kinase 2 6
MIRT458657 SGPP2 sphingosine-1-phosphate phosphatase 2 2 2
MIRT465898 TMEM41B transmembrane protein 41B 2 2
MIRT469877 PURB purine rich element binding protein B 2 4
MIRT470462 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT481439 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482643 RPL18A ribosomal protein L18a 2 2
MIRT486034 CYTH1 cytohesin 1 2 2
MIRT486423 RXRA retinoid X receptor alpha 2 2
MIRT490254 MFI2 melanotransferrin 2 2
MIRT491213 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT492849 NRGN neurogranin 2 2
MIRT492995 NAV1 neuron navigator 1 2 2
MIRT493423 KDM6B lysine demethylase 6B 2 2
MIRT495331 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT496865 C21orf2 chromosome 21 open reading frame 2 2 2
MIRT498435 EHD4 EH domain containing 4 2 2
MIRT514977 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT525668 KXD1 KxDL motif containing 1 2 2
MIRT564349 AKR1B10 aldo-keto reductase family 1 member B10 2 2
MIRT565241 TRAF6 TNF receptor associated factor 6 2 2
MIRT573209 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT635215 ZNF286A zinc finger protein 286A 2 4
MIRT638282 SH2B3 SH2B adaptor protein 3 2 2
MIRT650230 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT665256 ZNF286B zinc finger protein 286B 2 2
MIRT665833 TIMELESS timeless circadian clock 2 2
MIRT666891 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT667161 NRXN3 neurexin 3 2 2
MIRT679853 GPR75 G protein-coupled receptor 75 2 2
MIRT680747 CA5B carbonic anhydrase 5B 2 2
MIRT682071 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT695801 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT705465 ATG9A autophagy related 9A 2 2
MIRT714270 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT716392 NPAS1 neuronal PAS domain protein 1 2 2
MIRT718443 RAB11B RAB11B, member RAS oncogene family 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-3940-3p Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3940 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-miR-3940-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3940-3p Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3940-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3940-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-3940-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CP20)
hsa-miR-3940-3p Fluorouracil 3385 NSC19893 approved resistant cell line (HCT15)
hsa-miR-3940-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-3940-3p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-3940-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3940-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-3940-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3940-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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