pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RCAN1   
Synonyms ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
Description regulator of calcineurin 1
Transcript NM_004414   
Other Transcripts NM_203417 , NM_203418   
Expression
Putative miRNA Targets on RCAN1
3'UTR of RCAN1
(miRNA target sites are highlighted)
>RCAN1|NM_004414|3'UTR
   1 ACTGGCACGCGACGAGGACGCATTCCAAATCATACTCACGGGAGGAATCTTTTACTGTGGAGGTGGCTGGTCACGACTTC
  81 TTCGGAGGTGGCAGCCGAGATCGGGGTGGCAGAAATCCCAGTTCATGTTGCTCAGAAGAGAATCAAGGCCGTGTCCCCTT
 161 GTTCTAATGCTGCACACCAGTTACTGTTCATGGCACCCGGGAATGACTTGGGCCAATCACTGAGTTTGTGGTGATCGCAC
 241 AAGGACATTTGGGACTGTCTTGAGAAAACAGATAATGATAGTGTTTTGTACTTGTTCTTTTCTGGTAGGTTCTGTCTGTG
 321 CCAAGGGCAGGTTGATCAGTGAGCTCAGGAGAGAGCTTCCTGTTTCTAAGTGGCCTGCAGGGGCCACTCTCTACTGGTAG
 401 GAAGAGGTACCACAGGAAGCCGCCTAGTGCAGAGAGGTTGTGAAAACAGCAGCAATGCAATGTGGAAATTGTAGCGTTTC
 481 CTTTCTTCCCTCATGTTCTCATGTTTGTGCATGTATATTACTGATTTACAAGACTAACCTTTGTTCGTATATAAAGTTAC
 561 ACCGTTGTTGTTTTACATCTTTTGGGAAGCCAGGAAAGCGTTTGGAAAACGTATCACCTTTCCCAGATTCTCGGATTCTC
 641 GACTCTTTGCAACAGCACTTGCTTGCGGAACTCTTCCTGGAATGCATTCACTCAGCATCCCCAACCGTGCAACGTGTAAC
 721 TTGTGCTTTTGCAAAAGAAGTTGATCTGAAATTCCTCTGTAGAATTTAGCTTATACAATTCAGAGAATAGCAGTTTCACT
 801 GCCAACTTTTAGTGGGTGAGAAATTTTAGTTTAGGTGTTTGGGATCGGACCTCAGTTTCTGTTGTTTCTTTTATGTGGTG
 881 GTTTCTATACATGAATCATAGCCAAAAACTTTTTTGGAAACTGTTGGTTGAGATAGTTGGTTCTTTTACCCCACGAAGAC
 961 ATCAAGATACACTTGTAAATAAAGCTGATAGCATATATTCATACCTGTTGTACACTTGGGTGAAAAGTATGGCAGTGGGA
1041 GACTAAGATGTATTAACCTACCTGTGAATCATATGTTGTAGGAAAAGCTGTTCCCATGTCTAACAGGACTTGAATTCAAA
1121 GCATGTCAAGTGGATAGTAGATCTGTGGCGATATGAGAGGGATGCAGTGCCTTTCCCCATTCATTCCTGATGGAATTGTT
1201 ATACTAGGTTAACATTTGTAATTTTTTTCTAGTTGTAATGTGTATGTCTGGTAAATAGGTATTATATTTTGGCCTTACAA
1281 TACCGTAACAATGTTTGTCATTTTGAAATACTTAATGCCAAGTAACAATGCATGCTTTGGAAATTTGGAAGATGGTTTTA
1361 TTCTTTGAGAAGCAAATATGTTTGCATTAAATGCTTTGATTGTTCATATCAAGAAATTGATTGAACGTTCTCAAACCCTG
1441 TTTACGGTACTTGGTAAGAGGGAGCCGGTTTGGGAGAGACCATTGCATCGCTGTCCAAGTGTTTCTTGTTAAGTGCTTTT
1521 AAACTGGAGAGGCTAACCTCAAAATATTTTTTTTAACTGCATTCTATAATAAATGGGCACAGTATGCTCCTTACAGAAAA
1601 GTTGTCATTTTATTTCTAGAATAAATCTGTGAACCTTCTAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgguucccuUAC--CGUCCCUUUa 5'
                   |||  |:||| ||| 
Target 5' gtgaatcatATGTTGTAGGAAAAg 3'
1064 - 1087 119.00 -6.50
2
miRNA  3' cgguuCCCUUACCGUCCCUUUa 5'
               ||||| | |||| ||: 
Target 5' cttttGGGAA-GCCAGGAAAGc 3'
579 - 599 116.00 -11.40
3
miRNA  3' cggUUCCCUUACCGU--CCCUUUa 5'
             ||  | ||||||  ||||:| 
Target 5' gtgAAAAGTATGGCAGTGGGAGAc 3'
1020 - 1043 115.00 -16.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31558258 8 COSMIC
COSN20060650 10 COSMIC
COSN30668800 14 COSMIC
COSN31492959 22 COSMIC
COSN30457131 31 COSMIC
COSN26991838 40 COSMIC
COSN31521512 67 COSMIC
COSN30114000 83 COSMIC
COSN13882221 97 COSMIC
COSN26991837 103 COSMIC
COSN30451904 117 COSMIC
COSN31481396 133 COSMIC
COSN31583531 143 COSMIC
COSN30460580 189 COSMIC
COSN15942992 379 COSMIC
COSN10025983 387 COSMIC
COSN24828360 547 COSMIC
COSN24483821 1037 COSMIC
COSN31541089 1143 COSMIC
COSN24289450 1161 COSMIC
COSN23015603 1284 COSMIC
COSN22236520 1555 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs779981350 3 dbSNP
rs758710708 8 dbSNP
rs4336020 9 dbSNP
rs375236816 10 dbSNP
rs200513615 11 dbSNP
rs370671151 13 dbSNP
rs373976414 14 dbSNP
rs1326814880 17 dbSNP
rs1335248583 19 dbSNP
rs73367105 20 dbSNP
rs761183824 22 dbSNP
rs1362711860 32 dbSNP
rs773979412 35 dbSNP
rs201077551 37 dbSNP
rs568888709 39 dbSNP
rs754357693 40 dbSNP
rs759518300 40 dbSNP
rs556982728 41 dbSNP
rs1284693862 44 dbSNP
rs1322491081 45 dbSNP
rs1414504503 46 dbSNP
rs747939513 49 dbSNP
rs763747059 52 dbSNP
rs1007935708 62 dbSNP
rs1210884725 73 dbSNP
rs576014933 74 dbSNP
rs374486619 75 dbSNP
rs1244624939 77 dbSNP
rs982907409 84 dbSNP
rs996628403 87 dbSNP
rs903666411 88 dbSNP
rs371685457 96 dbSNP
rs868014396 102 dbSNP
rs141259241 103 dbSNP
rs892424891 104 dbSNP
rs1244995117 105 dbSNP
rs1056314277 107 dbSNP
rs1443934688 116 dbSNP
rs938648541 118 dbSNP
rs928663856 126 dbSNP
rs1221429396 130 dbSNP
rs1285171250 131 dbSNP
rs148238370 138 dbSNP
rs1018513303 144 dbSNP
rs1000389345 148 dbSNP
rs948852706 149 dbSNP
rs62211555 150 dbSNP
rs112506779 151 dbSNP
rs1009331760 154 dbSNP
rs1490302267 155 dbSNP
rs1365144712 157 dbSNP
rs1273312319 160 dbSNP
rs1197694543 162 dbSNP
rs892174764 173 dbSNP
rs1331785623 175 dbSNP
rs1478645548 183 dbSNP
rs1167780175 189 dbSNP
rs1416795188 190 dbSNP
rs1411110189 193 dbSNP
rs1308299929 196 dbSNP
rs767771087 198 dbSNP
rs761949192 199 dbSNP
rs1304730359 202 dbSNP
rs905015160 215 dbSNP
rs1464118121 216 dbSNP
rs987064378 236 dbSNP
rs1268298487 237 dbSNP
rs955191775 239 dbSNP
rs1337569010 240 dbSNP
rs941234788 242 dbSNP
rs1028013125 252 dbSNP
rs774759229 257 dbSNP
rs1171923644 260 dbSNP
rs909899593 272 dbSNP
rs1269928642 274 dbSNP
rs533295597 275 dbSNP
rs1190301307 278 dbSNP
rs930081165 288 dbSNP
rs1476135170 289 dbSNP
rs1478172537 291 dbSNP
rs922718879 301 dbSNP
rs768871580 309 dbSNP
rs1422367177 320 dbSNP
rs1165029465 321 dbSNP
rs1391220091 326 dbSNP
rs1381405864 340 dbSNP
rs976852519 341 dbSNP
rs1328112789 344 dbSNP
rs1176309004 345 dbSNP
rs1456928710 348 dbSNP
rs1358742043 353 dbSNP
rs562467340 354 dbSNP
rs1267412922 358 dbSNP
rs1357543317 359 dbSNP
rs1204893160 367 dbSNP
rs1022547658 376 dbSNP
rs1466635821 377 dbSNP
rs1189700347 378 dbSNP
rs1200397358 383 dbSNP
rs548628868 393 dbSNP
rs1442193075 407 dbSNP
rs979000549 412 dbSNP
rs1009318308 413 dbSNP
rs892305966 421 dbSNP
rs1056279083 422 dbSNP
rs1156587656 438 dbSNP
rs1386776601 442 dbSNP
rs1003431398 452 dbSNP
rs1346047229 454 dbSNP
rs1450501305 458 dbSNP
rs191115895 461 dbSNP
rs1315163264 464 dbSNP
rs968913926 475 dbSNP
rs1238869842 476 dbSNP
rs550601089 484 dbSNP
rs1044431247 494 dbSNP
rs188641039 500 dbSNP
rs760309331 503 dbSNP
rs1459623461 507 dbSNP
rs1003276577 515 dbSNP
rs573274768 516 dbSNP
rs1256499524 517 dbSNP
rs561649145 538 dbSNP
rs1413927722 546 dbSNP
rs776431947 547 dbSNP
rs1175666414 552 dbSNP
rs908728703 563 dbSNP
rs1403784904 564 dbSNP
rs1468350588 564 dbSNP
rs1304657227 566 dbSNP
rs1402922515 567 dbSNP
rs905046274 568 dbSNP
rs1305075469 570 dbSNP
rs1044894354 572 dbSNP
rs1175850900 575 dbSNP
rs1229365078 577 dbSNP
rs770621618 579 dbSNP
rs1415393947 580 dbSNP
rs1322021628 587 dbSNP
rs540785905 590 dbSNP
rs1256087212 599 dbSNP
rs554708492 600 dbSNP
rs1193743550 606 dbSNP
rs536245366 610 dbSNP
rs564730886 611 dbSNP
rs776731349 617 dbSNP
rs1434845366 624 dbSNP
rs1176632618 626 dbSNP
rs1378304049 628 dbSNP
rs11702730 632 dbSNP
rs1461514164 633 dbSNP
rs866462157 633 dbSNP
rs879236969 640 dbSNP
rs1482258809 641 dbSNP
rs922614326 649 dbSNP
rs1302926519 659 dbSNP
rs1041132081 665 dbSNP
rs1389054619 666 dbSNP
rs546084400 667 dbSNP
rs1306455112 668 dbSNP
rs1224583211 674 dbSNP
rs1276405702 678 dbSNP
rs11539116 680 dbSNP
rs1236811105 694 dbSNP
rs1021968100 698 dbSNP
rs1009282467 704 dbSNP
rs1266527398 707 dbSNP
rs1489312379 711 dbSNP
rs956512891 713 dbSNP
rs575574267 714 dbSNP
rs978865152 732 dbSNP
rs947664668 745 dbSNP
rs1210636827 746 dbSNP
rs1392332874 758 dbSNP
rs1443861655 760 dbSNP
rs183409561 781 dbSNP
rs1310089175 784 dbSNP
rs535461381 788 dbSNP
rs1034838098 792 dbSNP
rs1238180982 793 dbSNP
rs1439010198 808 dbSNP
rs575194876 810 dbSNP
rs761357863 815 dbSNP
rs747608432 831 dbSNP
rs1380093186 834 dbSNP
rs1299181239 839 dbSNP
rs563085043 844 dbSNP
rs981870550 846 dbSNP
rs778463183 847 dbSNP
rs1323325778 850 dbSNP
rs1222007290 869 dbSNP
rs969095141 880 dbSNP
rs1484852231 881 dbSNP
rs1012880109 887 dbSNP
rs1190366330 891 dbSNP
rs898498023 921 dbSNP
rs1450116791 939 dbSNP
rs1183261179 940 dbSNP
rs1411868456 950 dbSNP
rs190415849 954 dbSNP
rs1165922146 956 dbSNP
rs940111139 957 dbSNP
rs1456125549 963 dbSNP
rs1804576 970 dbSNP
rs1323084129 984 dbSNP
rs1005429294 1004 dbSNP
rs535155443 1005 dbSNP
rs1026008977 1006 dbSNP
rs1377595981 1016 dbSNP
rs1380877858 1027 dbSNP
rs1295988347 1029 dbSNP
rs994079732 1031 dbSNP
rs901185376 1032 dbSNP
rs1314857821 1035 dbSNP
rs200634825 1040 dbSNP
rs1210545689 1052 dbSNP
rs1268648134 1071 dbSNP
rs1051301685 1073 dbSNP
rs1380497958 1082 dbSNP
rs1203097294 1090 dbSNP
rs754594610 1096 dbSNP
rs1040992967 1098 dbSNP
rs1473899234 1102 dbSNP
rs149584432 1105 dbSNP
rs976080879 1109 dbSNP
rs1407746567 1116 dbSNP
rs889826784 1127 dbSNP
rs754166419 1133 dbSNP
rs551602359 1138 dbSNP
rs914924538 1149 dbSNP
rs1331623254 1177 dbSNP
rs556046561 1179 dbSNP
rs956481900 1198 dbSNP
rs913383553 1199 dbSNP
rs1297207406 1205 dbSNP
rs879403170 1216 dbSNP
rs780523566 1220 dbSNP
rs8320 1229 dbSNP
rs1034807049 1243 dbSNP
rs756431079 1246 dbSNP
rs1288975969 1247 dbSNP
rs1215579504 1259 dbSNP
rs982005147 1261 dbSNP
rs1221537379 1263 dbSNP
rs6741 1278 dbSNP
rs1444155755 1283 dbSNP
rs1023518713 1284 dbSNP
rs1319936428 1285 dbSNP
rs1482307714 1290 dbSNP
rs1184771825 1291 dbSNP
rs1480400592 1297 dbSNP
rs569174567 1303 dbSNP
rs550564272 1304 dbSNP
rs969041446 1323 dbSNP
rs1169363506 1329 dbSNP
rs1368299604 1332 dbSNP
rs1411501619 1333 dbSNP
rs1308416315 1348 dbSNP
rs762002330 1349 dbSNP
rs1004293108 1360 dbSNP
rs56050259 1369 dbSNP
rs887231283 1372 dbSNP
rs1347271236 1378 dbSNP
rs764224416 1386 dbSNP
rs1357792490 1391 dbSNP
rs1060267 1406 dbSNP
rs1274264244 1409 dbSNP
rs1051186294 1412 dbSNP
rs1276744838 1415 dbSNP
rs934143393 1416 dbSNP
rs1340300848 1417 dbSNP
rs867580444 1421 dbSNP
rs14676 1427 dbSNP
rs1490276387 1434 dbSNP
rs763297140 1436 dbSNP
rs1248936357 1438 dbSNP
rs1478100716 1439 dbSNP
rs1360836966 1444 dbSNP
rs946980266 1445 dbSNP
rs768862139 1446 dbSNP
rs914893560 1447 dbSNP
rs994502997 1449 dbSNP
rs987798642 1450 dbSNP
rs77066172 1460 dbSNP
rs1019575482 1467 dbSNP
rs1331598294 1477 dbSNP
rs1165434963 1478 dbSNP
rs1296977561 1482 dbSNP
rs927677138 1483 dbSNP
rs771746247 1487 dbSNP
rs1476167523 1488 dbSNP
rs889775822 1489 dbSNP
rs982277158 1490 dbSNP
rs969220691 1492 dbSNP
rs1023912845 1493 dbSNP
rs775572999 1496 dbSNP
rs1356147822 1498 dbSNP
rs1208414329 1505 dbSNP
rs947472917 1508 dbSNP
rs1478021714 1510 dbSNP
rs1452696060 1513 dbSNP
rs1060272 1515 dbSNP
rs1188421744 1533 dbSNP
rs973330655 1534 dbSNP
rs963324404 1535 dbSNP
rs867241197 1543 dbSNP
rs1016943967 1544 dbSNP
rs1188851705 1545 dbSNP
rs1060273 1547 dbSNP
rs1053258152 1555 dbSNP
rs938937212 1555 dbSNP
rs1060276 1556 dbSNP
rs1400056933 1561 dbSNP
rs1318408535 1567 dbSNP
rs1386592552 1570 dbSNP
rs1437334980 1573 dbSNP
rs1298682559 1574 dbSNP
rs1487561600 1579 dbSNP
rs887117219 1581 dbSNP
rs928913253 1585 dbSNP
rs1264899364 1586 dbSNP
rs1029720523 1591 dbSNP
rs1242795079 1597 dbSNP
rs1214365578 1602 dbSNP
rs998692707 1604 dbSNP
rs760441181 1606 dbSNP
rs1357437739 1607 dbSNP
rs1417480752 1618 dbSNP
rs1208683964 1628 dbSNP
rs1040302368 1631 dbSNP
rs74326445 1632 dbSNP
rs947732661 1634 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            |||  |||   |||||||| 
Target 5' -gCAA--GAA---CAGGGAAAa 3'
1 - 16
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000482533.1 | 3UTR | AACAGGGAAAAAGAGAGAGAGAGAGAGAGAGAGACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000482533.1 | 3UTR | AAAAGAGAGAGAGAGAGAGAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000482533.1 | 3UTR | GCAAGAACAGGGAAAAAGAGAGAGAGAGAGAGAGAGAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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