pre-miRNA Information
pre-miRNA hsa-mir-23a   
Genomic Coordinates chr19: 13836587 - 13836659
Synonyms MIRN23A, hsa-mir-23a, miRNA23A, MIR23A
Description Homo sapiens miR-23a stem-loop
Comment This miRNA was previously named miR-23 . This finding was later retracted after the discovery that the regulated gene was human homolog of ES1 (HES1), whose function is unknown.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-23a-5p
Sequence 9| GGGGUUCCUGGGGAUGGGAUUU |30
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs748509260 12 dbSNP
rs1205403719 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GSR   
Synonyms HEL-75, HEL-S-122m
Description glutathione-disulfide reductase
Transcript NM_000637   
Expression
Putative miRNA Targets on GSR
3'UTR of GSR
(miRNA target sites are highlighted)
>GSR|NM_000637|3'UTR
   1 GAACCAGGAGACACGTGTGGCGGGCAGTGGGACCCATAGATCTTCTGAAATGAAACAAATAATCACATTGACTTACTGTT
  81 TGAGTTTTATGTATTTCTTTATTTTAATCAGGATCTTCTGATAGTGGAAATTTTTAGTACATAATAGAACTTATTTATGG
 161 AGTTAGAAATTTGTAGTGTTATCCAGGATTGATTTTCATTTGATCACATCTCACAGTAATTAATATTTTCAAGTTTTTTT
 241 TTTATTAACAGCTCTGTGCTAGTTTTTTTTTTCTGTTTTAGCCTCATCCCAAATATAAAGCTTTGTGAAGTACAATTAAC
 321 TTAATGTACTTGAATGAATAGAACTTGCTACTTTTTTTTTTTTTTTTTTTGAGACAGAGTTTTGCTCTCATTGCCCAGGC
 401 TGGAGTGCGGTGGTGCTATTTCAGCTCACCACAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTTAGCCTCCCGA
 481 ATAGCTGGAATTACAGGCACGCACCACCATGCCTGACTAATTTTGTATTTTTAGTAGACATGGGGTTTCTCCATGTTGGT
 561 CAGGCTGGTCTCAAACTCCCACCTTCAGGTGATCCGCCCACCTCGGCCTCCTGAGGTGCTGAGATTACAGGCGTGAGCCA
 641 CTGTGCCAGCTTGCTAATTTTCACAGAAGTTGATGGCAATTCTTCACATGTAAACAGTGCCAGTGCACAGAACCTTTATA
 721 TATTTTTTGAAGCCAGTACTGTGCTCTGCATATAACAAAGCTGCTTCAAGGATGAGACCTTTTTCTAAAAGCATGTAATG
 801 TGAGAAGCCGGCCTGCCTTATTTTCTTTTTTCTTTTTTAATGATTAAAAATAGTTTGTGGCAAGGCACGGTGGCTCAGGC
 881 CTGTAATTCTAGCACTTTGGGAGGCCGAGGCAGGAGGATTACTTGAGCCTACAAGTTTGAGGCCAGCATGCACAGCATAG
 961 CAAGACTGCATCTCTACAGAGAGTAAAAAAAATTACCCGAGTGTGGTGATGTGCATCTGTAATCTCAGCTACTTGGGAGG
1041 CTGAGGTGAGAGGATCACTTGAGCTTGGGTGAGGTGAGGCTGCAGTGAGTCCTGATCATGCTGCTGCACTCAATCTTGGA
1121 CAACAGAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAAAATATATATATATATATATATTATTTTTATGAGGTGAAGTGC
1201 ATCAAACTTGGGAAAGATTTGAGGAGGCTGGGAACCTCCTGGAAAACCACTCCTTGAAGAAAGATATGAGAGACATTTAG
1281 AAGTGATTCCTGCTTTCAGAAGGAGGTGGATTCAAATACATCAAAAGTCCCTTCCTCTGCTAAGTGTTTATAGTTCAATG
1361 AATAATTTCAATATTTGTATGTGTTCTTGTCATTTTATTTTTTTCTGAAAAACTTCCAAAAATTTGAAAATAAAATTACA
1441 GCCTTTTCTTCTTATAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uuuaggguaggGGUCCUUGGGg 5'
                     |::||||||: 
Target 5' atttgaggaggCTGGGAACCTc 3'
1217 - 1238 131.00 -16.60
2
miRNA  3' uuuaggguagggguCCUUGGGg 5'
                        ||:|||| 
Target 5' gtgtggcgggcagtGGGACCCa 3'
15 - 36 124.00 -14.00
3
miRNA  3' uuuAGGGUAGGGGUCC-UUGGGg 5'
             ||||| |::|||| :|:|| 
Target 5' aacTCCCACCTTCAGGTGATCCg 3'
574 - 596 115.00 -21.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30172082 8 COSMIC
COSN31583967 15 COSMIC
COSN30547754 20 COSMIC
COSN31558146 21 COSMIC
COSN20076321 24 COSMIC
COSN30504037 30 COSMIC
COSN31540022 39 COSMIC
COSN14339897 40 COSMIC
COSN30146103 47 COSMIC
COSN30105581 68 COSMIC
COSN31516492 104 COSMIC
COSN31583621 147 COSMIC
COSN26438253 168 COSMIC
COSN27198914 262 COSMIC
COSN8079601 512 COSMIC
COSN20923753 633 COSMIC
COSN29810865 1032 COSMIC
COSN27880601 1453 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs915133836 1 dbSNP
rs989815814 13 dbSNP
rs746333168 14 dbSNP
rs779495845 15 dbSNP
rs1269909029 16 dbSNP
rs1189751431 19 dbSNP
rs757538187 20 dbSNP
rs763647057 21 dbSNP
rs373481457 22 dbSNP
rs752407262 24 dbSNP
rs767063881 27 dbSNP
rs560445388 37 dbSNP
rs200171779 39 dbSNP
rs369230085 40 dbSNP
rs1227267758 41 dbSNP
rs35768151 45 dbSNP
rs766391628 46 dbSNP
rs376582793 47 dbSNP
rs1307219338 48 dbSNP
rs762626909 50 dbSNP
rs1238709555 51 dbSNP
rs1043070487 57 dbSNP
rs1285022324 63 dbSNP
rs1031274834 69 dbSNP
rs1212847603 71 dbSNP
rs946084592 77 dbSNP
rs976521866 80 dbSNP
rs1181386365 83 dbSNP
rs1456965023 90 dbSNP
rs1408855740 97 dbSNP
rs1421095137 105 dbSNP
rs1157154920 107 dbSNP
rs1380002671 108 dbSNP
rs1435745211 111 dbSNP
rs965092617 115 dbSNP
rs913356131 121 dbSNP
rs1018039811 124 dbSNP
rs1233098668 125 dbSNP
rs1006538851 126 dbSNP
rs1374950640 134 dbSNP
rs1237497907 140 dbSNP
rs8191039 150 dbSNP
rs1348252092 158 dbSNP
rs1554991 166 dbSNP
rs1350422807 176 dbSNP
rs1277571954 187 dbSNP
rs537510398 198 dbSNP
rs1234793461 206 dbSNP
rs775863520 207 dbSNP
rs1441738272 211 dbSNP
rs1205194151 214 dbSNP
rs897993411 216 dbSNP
rs1233520270 219 dbSNP
rs188338725 220 dbSNP
rs769723357 226 dbSNP
rs1238051306 239 dbSNP
rs745646630 244 dbSNP
rs8191040 244 dbSNP
rs985683274 244 dbSNP
rs961414345 273 dbSNP
rs993849298 273 dbSNP
rs1372768975 275 dbSNP
rs1355703837 290 dbSNP
rs745982539 292 dbSNP
rs776626325 295 dbSNP
rs1045142048 306 dbSNP
rs948028340 317 dbSNP
rs1443950777 325 dbSNP
rs1024759364 329 dbSNP
rs1371317173 329 dbSNP
rs1442700031 330 dbSNP
rs1444544575 348 dbSNP
rs995344564 350 dbSNP
rs1337723819 351 dbSNP
rs1344123782 352 dbSNP
rs1435780394 352 dbSNP
rs1397397854 356 dbSNP
rs1215021256 359 dbSNP
rs1275045838 359 dbSNP
rs1320035861 364 dbSNP
rs1157454862 367 dbSNP
rs1417991781 368 dbSNP
rs1408007631 370 dbSNP
rs1332515827 371 dbSNP
rs1422637723 371 dbSNP
rs1477905805 371 dbSNP
rs1491024915 371 dbSNP
rs35555269 371 dbSNP
rs397893015 371 dbSNP
rs71823444 371 dbSNP
rs1178436160 372 dbSNP
rs1422296915 372 dbSNP
rs1471583522 381 dbSNP
rs1463567918 385 dbSNP
rs1169303871 396 dbSNP
rs576245359 402 dbSNP
rs1394644367 408 dbSNP
rs915257232 409 dbSNP
rs1321182972 411 dbSNP
rs1053690295 413 dbSNP
rs1013358894 416 dbSNP
rs1271818925 418 dbSNP
rs1486567101 419 dbSNP
rs1338299405 442 dbSNP
rs2551733 443 dbSNP
rs1283780376 444 dbSNP
rs1381680907 445 dbSNP
rs1138054 456 dbSNP
rs1317450687 457 dbSNP
rs1288006303 460 dbSNP
rs1054897479 463 dbSNP
rs1307739732 478 dbSNP
rs1265842778 479 dbSNP
rs1000704509 490 dbSNP
rs1193648305 491 dbSNP
rs756558112 500 dbSNP
rs976954120 501 dbSNP
rs1389609959 502 dbSNP
rs903772302 506 dbSNP
rs8191041 509 dbSNP
rs946104503 512 dbSNP
rs910945348 513 dbSNP
rs1415781551 515 dbSNP
rs1399323403 519 dbSNP
rs913296522 523 dbSNP
rs146973669 525 dbSNP
rs1356101536 527 dbSNP
rs944119784 534 dbSNP
rs747535348 536 dbSNP
rs911366325 539 dbSNP
rs553455623 540 dbSNP
rs1205995257 541 dbSNP
rs534116515 542 dbSNP
rs1487550820 544 dbSNP
rs1216451149 553 dbSNP
rs11552962 557 dbSNP
rs962571092 568 dbSNP
rs1443604033 579 dbSNP
rs972803607 582 dbSNP
rs1367437229 594 dbSNP
rs961100745 595 dbSNP
rs568218175 596 dbSNP
rs1416707352 597 dbSNP
rs10216724 600 dbSNP
rs1024662150 602 dbSNP
rs1377230398 603 dbSNP
rs570052585 604 dbSNP
rs1475990824 605 dbSNP
rs531396090 608 dbSNP
rs2551734 609 dbSNP
rs182562887 610 dbSNP
rs2551735 612 dbSNP
rs1033434143 618 dbSNP
rs1351901157 619 dbSNP
rs1239914887 628 dbSNP
rs1185742908 631 dbSNP
rs1484511271 632 dbSNP
rs552233138 633 dbSNP
rs1262468819 640 dbSNP
rs1217998528 643 dbSNP
rs758775349 644 dbSNP
rs1000692938 645 dbSNP
rs1437905131 646 dbSNP
rs370089677 650 dbSNP
rs1236008686 652 dbSNP
rs796525475 656 dbSNP
rs1234072551 664 dbSNP
rs1010633614 667 dbSNP
rs1276656463 669 dbSNP
rs747732351 686 dbSNP
rs1464472898 687 dbSNP
rs572203293 690 dbSNP
rs2551736 692 dbSNP
rs376725408 694 dbSNP
rs532433375 697 dbSNP
rs1333567737 700 dbSNP
rs1455919838 701 dbSNP
rs935350272 704 dbSNP
rs1446382899 705 dbSNP
rs1049920224 713 dbSNP
rs923830521 714 dbSNP
rs1040997301 715 dbSNP
rs1255939279 717 dbSNP
rs1247894811 718 dbSNP
rs931534610 722 dbSNP
rs1200021275 724 dbSNP
rs943841694 741 dbSNP
rs1457025399 746 dbSNP
rs1193939529 753 dbSNP
rs1165014721 756 dbSNP
rs1269198381 767 dbSNP
rs1431234229 768 dbSNP
rs911084307 772 dbSNP
rs1198022959 774 dbSNP
rs2551737 776 dbSNP
rs985205540 777 dbSNP
rs1467156451 778 dbSNP
rs1488980944 785 dbSNP
rs560554376 799 dbSNP
rs1172879342 803 dbSNP
rs8191042 809 dbSNP
rs189893412 810 dbSNP
rs1294342198 811 dbSNP
rs919693237 812 dbSNP
rs940285332 817 dbSNP
rs780670699 823 dbSNP
rs1301143187 833 dbSNP
rs1327502710 839 dbSNP
rs972769308 842 dbSNP
rs2551738 844 dbSNP
rs961087537 855 dbSNP
rs561413733 856 dbSNP
rs982358219 867 dbSNP
rs970851120 868 dbSNP
rs548572777 869 dbSNP
rs769634423 870 dbSNP
rs1467989223 872 dbSNP
rs1252380734 874 dbSNP
rs1487359822 883 dbSNP
rs1208987400 888 dbSNP
rs1262226513 889 dbSNP
rs1478753745 890 dbSNP
rs1214438137 892 dbSNP
rs1421484082 894 dbSNP
rs1477541830 895 dbSNP
rs1033422737 897 dbSNP
rs1012277169 898 dbSNP
rs893845273 906 dbSNP
rs142939376 907 dbSNP
rs1402394729 913 dbSNP
rs562606451 927 dbSNP
rs1009455056 928 dbSNP
rs1228426628 928 dbSNP
rs1314297202 931 dbSNP
rs901767707 935 dbSNP
rs1019589288 937 dbSNP
rs2551739 941 dbSNP
rs1243684812 942 dbSNP
rs902542269 944 dbSNP
rs545931781 946 dbSNP
rs1489149267 948 dbSNP
rs11552954 959 dbSNP
rs8191043 965 dbSNP
rs943977533 966 dbSNP
rs554763667 980 dbSNP
rs1049557868 981 dbSNP
rs1325936272 989 dbSNP
rs1164431712 990 dbSNP
rs898640906 993 dbSNP
rs185133657 998 dbSNP
rs753362892 999 dbSNP
rs991777204 1000 dbSNP
rs117945775 1002 dbSNP
rs939667397 1004 dbSNP
rs928326642 1005 dbSNP
rs1462294380 1008 dbSNP
rs1395020037 1011 dbSNP
rs1374526204 1013 dbSNP
rs1309546984 1014 dbSNP
rs926354731 1015 dbSNP
rs1138089 1021 dbSNP
rs1138092 1022 dbSNP
rs1237735498 1023 dbSNP
rs1285097509 1043 dbSNP
rs1453682739 1052 dbSNP
rs1395642425 1053 dbSNP
rs1348481447 1055 dbSNP
rs1138107 1057 dbSNP
rs1194318513 1072 dbSNP
rs1469911795 1080 dbSNP
rs1212228381 1082 dbSNP
rs182290262 1083 dbSNP
rs1138117 1084 dbSNP
rs1195383463 1087 dbSNP
rs1481083055 1096 dbSNP
rs970985878 1097 dbSNP
rs1239041482 1104 dbSNP
rs1253401345 1118 dbSNP
rs1441817710 1123 dbSNP
rs1232575803 1134 dbSNP
rs1347763285 1136 dbSNP
rs1380135394 1138 dbSNP
rs1304861139 1139 dbSNP
rs1415540403 1142 dbSNP
rs1178870189 1143 dbSNP
rs1356874492 1145 dbSNP
rs1446675817 1146 dbSNP
rs1235843945 1147 dbSNP
rs1444191281 1149 dbSNP
rs1374090529 1151 dbSNP
rs1023845338 1152 dbSNP
rs991374147 1153 dbSNP
rs866409942 1154 dbSNP
rs397717424 1155 dbSNP
rs199730579 1156 dbSNP
rs2911680 1157 dbSNP
rs1175515974 1158 dbSNP
rs3201906 1159 dbSNP
rs1491123637 1160 dbSNP
rs1004949759 1161 dbSNP
rs10558838 1161 dbSNP
rs1278914384 1161 dbSNP
rs1286902707 1161 dbSNP
rs1414443911 1161 dbSNP
rs1423717943 1161 dbSNP
rs1438375119 1161 dbSNP
rs1491429446 1161 dbSNP
rs202060962 1161 dbSNP
rs59845294 1161 dbSNP
rs67803604 1161 dbSNP
rs869129450 1161 dbSNP
rs1437760560 1162 dbSNP
rs1196918225 1163 dbSNP
rs1238338069 1163 dbSNP
rs1245396708 1163 dbSNP
rs1272586413 1163 dbSNP
rs1452507141 1163 dbSNP
rs1477983194 1163 dbSNP
rs958244165 1163 dbSNP
rs1362065797 1164 dbSNP
rs1425070786 1164 dbSNP
rs1169457713 1165 dbSNP
rs1334217362 1165 dbSNP
rs1476563336 1165 dbSNP
rs1406777145 1170 dbSNP
rs1321323701 1171 dbSNP
rs1181215277 1173 dbSNP
rs1032828274 1174 dbSNP
rs999641788 1176 dbSNP
rs1177002282 1180 dbSNP
rs1303615569 1180 dbSNP
rs1342393716 1180 dbSNP
rs1419839685 1182 dbSNP
rs1216906307 1190 dbSNP
rs1269711012 1200 dbSNP
rs1020754187 1202 dbSNP
rs554565893 1215 dbSNP
rs1288165538 1216 dbSNP
rs902510677 1232 dbSNP
rs1217918698 1250 dbSNP
rs1019662893 1258 dbSNP
rs1485586865 1263 dbSNP
rs965951589 1274 dbSNP
rs1281648457 1275 dbSNP
rs1213575842 1296 dbSNP
rs1411944019 1303 dbSNP
rs1191808263 1304 dbSNP
rs1008241621 1308 dbSNP
rs11552958 1310 dbSNP
rs1473572058 1314 dbSNP
rs1161097375 1319 dbSNP
rs1278405677 1323 dbSNP
rs1008220190 1330 dbSNP
rs889815572 1337 dbSNP
rs1160340352 1340 dbSNP
rs1337143583 1348 dbSNP
rs1291103013 1350 dbSNP
rs1317714109 1351 dbSNP
rs1341218184 1353 dbSNP
rs1450388995 1360 dbSNP
rs1028761294 1363 dbSNP
rs1359112058 1370 dbSNP
rs1241369655 1371 dbSNP
rs3594 1377 dbSNP
rs1314494069 1379 dbSNP
rs1352120508 1380 dbSNP
rs1205125523 1387 dbSNP
rs898577078 1389 dbSNP
rs1443653702 1397 dbSNP
rs1184896220 1401 dbSNP
rs1242176424 1403 dbSNP
rs192474167 1404 dbSNP
rs1158041638 1405 dbSNP
rs1160207037 1405 dbSNP
rs538747691 1419 dbSNP
rs1452966677 1422 dbSNP
rs1173097044 1423 dbSNP
rs746553094 1427 dbSNP
rs1037169285 1431 dbSNP
rs938282856 1434 dbSNP
rs1382272614 1435 dbSNP
rs926261399 1442 dbSNP
rs1375151388 1454 dbSNP
rs756212793 1454 dbSNP
rs1238888194 1455 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuuaggguaggggucCUUGGGg 5'
                         |||||| 
Target 5' -caggagaaugguguGAACCCa 3'
1 - 21
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' uuuaggguaggggucCUUGGGg 5'
                         |||||| 
Target 5' -caggagaaugguguGAACCCa 3'
1 - 21
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000221130.5 | 3UTR | CAGGAGAAUGGUGUGAACCCAGGAGGCGGAGCUUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000221130.5 | 3UTR | CAGGAGAAUGGUGUGAACCCAGGAGGCGGAGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.709 5.3e-5 0.664 2.0e-4 24 Click to see details
GSE21032 Prostate cancer -0.256 9.7e-3 -0.205 3.2e-2 83 Click to see details
GSE38226 Liver fibrosis -0.421 2.9e-2 -0.527 7.0e-3 21 Click to see details
GSE19783 ER+ ER+ breast cancer -0.394 4.3e-2 -0.337 7.3e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.251 1.4e-1 0.478 1.7e-2 20 Click to see details
GSE19350 CNS germ cell tumors -0.286 1.8e-1 -0.156 3.1e-1 12 Click to see details
GSE28260 Renal cortex and medulla -0.27 1.9e-1 -0.423 7.5e-2 13 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.265 2.5e-1 0.200 3.0e-1 9 Click to see details
GSE42095 Differentiated embryonic stem cells 0.149 2.5e-1 -0.008 4.9e-1 23 Click to see details
GSE26953 Aortic valvular endothelial cells 0.144 2.5e-1 0.263 1.1e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.1 2.9e-1 -0.179 1.6e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.06 3.2e-1 0.020 4.4e-1 64 Click to see details
GSE19536 Breast cancer -0.039 3.5e-1 -0.091 1.8e-1 100 Click to see details
GSE19783 ER- ER- breast cancer 0.04 3.6e-1 -0.006 4.8e-1 79 Click to see details
GSE17498 Multiple myeloma 0.046 3.9e-1 0.256 5.5e-2 40 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.021 4.6e-1 0.129 2.7e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.021 4.6e-1 0.025 4.5e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC -0.4 0 -0.403 0 62 Click to see details
THCA 0.24 0.03 0.229 0.04 59 Click to see details
STAD 0.348 0.03 0.446 0.01 28 Click to see details
ESCA 0.532 0.05 0.345 0.15 11 Click to see details
BLCA -0.273 0.15 -0.341 0.1 16 Click to see details
LUAD 0.373 0.16 0.433 0.12 9 Click to see details
PAAD -0.664 0.17 -0.200 0.4 4 Click to see details
CESC -0.852 0.18 -1.000 0.5 3 Click to see details
HNSC 0.149 0.18 0.093 0.28 40 Click to see details
LUSC -0.15 0.18 -0.123 0.23 38 Click to see details
PRAD 0.186 0.22 0.253 0.15 19 Click to see details
UCEC 0.176 0.24 0.342 0.08 19 Click to see details
KIRP 0.112 0.27 0.096 0.3 32 Click to see details
KICH -0.128 0.3 -0.039 0.44 20 Click to see details
PCPG -0.546 0.32 -0.500 0.33 3 Click to see details
LIHC 0.022 0.45 0.085 0.31 38 Click to see details
COAD -0.051 0.45 -0.071 0.43 8 Click to see details
CHOL 0.051 0.45 0.095 0.41 8 Click to see details
BRCA 0.007 0.48 0.090 0.22 78 Click to see details
BRCA 0.007 0.48 0.090 0.22 78 Click to see details
BRCA 0.007 0.48 0.090 0.22 78 Click to see details
131 hsa-miR-23a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038958 ATF1 activating transcription factor 1 1 1
MIRT057661 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT395438 NFKBID NFKB inhibitor delta 2 2
MIRT463884 WNT7B Wnt family member 7B 2 4
MIRT475804 HDGF heparin binding growth factor 2 2
MIRT478528 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT479278 CHD4 chromodomain helicase DNA binding protein 4 2 6
MIRT492564 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT500353 ZNF385A zinc finger protein 385A 2 2
MIRT509788 CHAF1B chromatin assembly factor 1 subunit B 2 4
MIRT511566 HIST3H2BB histone cluster 3 H2B family member b 2 4
MIRT525450 GPATCH2L G-patch domain containing 2 like 2 2
MIRT539558 CNKSR3 CNKSR family member 3 2 4
MIRT540034 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT540225 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT540242 RGS17 regulator of G protein signaling 17 2 2
MIRT540871 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT559065 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT560685 HIST1H1T histone cluster 1 H1 family member t 2 2
MIRT565593 SLC35G1 solute carrier family 35 member G1 2 2
MIRT565642 SKI SKI proto-oncogene 2 2
MIRT576747 Tmem127 transmembrane protein 127 2 2
MIRT607712 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT615682 NAV2 neuron navigator 2 2 2
MIRT617337 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT617378 FAM227A family with sequence similarity 227 member A 2 2
MIRT620855 SERPING1 serpin family G member 1 2 2
MIRT625112 SLC1A5 solute carrier family 1 member 5 2 2
MIRT625124 NUP93 nucleoporin 93 2 2
MIRT625898 LINC00632 long intergenic non-protein coding RNA 632 2 2
MIRT626016 XRCC2 X-ray repair cross complementing 2 2 2
MIRT626481 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT626573 MED7 mediator complex subunit 7 2 2
MIRT626814 PRR11 proline rich 11 2 2
MIRT628136 HM13 histocompatibility minor 13 2 2
MIRT630771 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT633133 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT636950 APTX aprataxin 2 2
MIRT637802 GGPS1 geranylgeranyl diphosphate synthase 1 2 2
MIRT638622 GSR glutathione-disulfide reductase 2 4
MIRT642196 SMAGP small cell adhesion glycoprotein 2 2
MIRT645121 HES2 hes family bHLH transcription factor 2 2 2
MIRT645344 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT646564 ALDH5A1 aldehyde dehydrogenase 5 family member A1 2 2
MIRT649243 TRIM65 tripartite motif containing 65 2 2
MIRT651810 USP49 ubiquitin specific peptidase 49 2 2
MIRT652137 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT652668 TIMELESS timeless circadian clock 2 2
MIRT655894 NEK9 NIMA related kinase 9 2 2
MIRT656564 LYRM7 LYR motif containing 7 2 2
MIRT657194 IKZF3 IKAROS family zinc finger 3 2 2
MIRT657907 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT660207 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT660619 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT660826 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT660986 ABHD2 abhydrolase domain containing 2 2 2
MIRT662232 PGBD4 piggyBac transposable element derived 4 2 2
MIRT663691 ZNF347 zinc finger protein 347 2 2
MIRT665577 TUBD1 tubulin delta 1 2 2
MIRT666149 SP2 Sp2 transcription factor 2 2
MIRT666310 SLC22A3 solute carrier family 22 member 3 2 2
MIRT666457 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT667716 KIAA1468 KIAA1468 2 2
MIRT668329 FKBP5 FK506 binding protein 5 2 2
MIRT668370 FBXO47 F-box protein 47 2 2
MIRT669304 C17orf75 chromosome 17 open reading frame 75 2 2
MIRT669538 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT671681 ADK adenosine kinase 2 2
MIRT672177 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT673604 HPSE heparanase 2 2
MIRT673749 ZNF333 zinc finger protein 333 2 2
MIRT674807 FAM229B family with sequence similarity 229 member B 2 2
MIRT675286 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT675391 SVOP SV2 related protein 2 2
MIRT675788 MED28 mediator complex subunit 28 2 2
MIRT676151 OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 2 2
MIRT676499 GJD3 gap junction protein delta 3 2 2
MIRT676621 CSNK1E casein kinase 1 epsilon 2 2
MIRT676644 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT676711 METTL14 methyltransferase like 14 2 2
MIRT676809 SHROOM4 shroom family member 4 2 2
MIRT677036 FOXO3 forkhead box O3 2 2
MIRT677062 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT677086 SMIM15 small integral membrane protein 15 2 2
MIRT677193 MURC caveolae associated protein 4 2 2
MIRT677273 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT677345 POC1A POC1 centriolar protein A 2 2
MIRT677504 SLC10A6 solute carrier family 10 member 6 2 2
MIRT677526 OCIAD2 OCIA domain containing 2 2 2
MIRT677661 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT677727 SSR1 signal sequence receptor subunit 1 2 2
MIRT677803 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT678144 SLC4A4 solute carrier family 4 member 4 2 2
MIRT678376 VTA1 vesicle trafficking 1 2 2
MIRT678708 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT678868 FAM118A family with sequence similarity 118 member A 2 2
MIRT679039 LACTB lactamase beta 2 2
MIRT679081 PURB purine rich element binding protein B 2 2
MIRT679137 SYK spleen associated tyrosine kinase 2 2
MIRT679299 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679741 CABP4 calcium binding protein 4 2 2
MIRT679946 AS3MT arsenite methyltransferase 2 2
MIRT679976 E2F2 E2F transcription factor 2 2 2
MIRT683628 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT683901 PSMB9 proteasome subunit beta 9 2 2
MIRT684172 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT684231 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT685403 C1orf158 chromosome 1 open reading frame 158 2 2
MIRT686253 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT687513 NCKAP1 NCK associated protein 1 2 2
MIRT688243 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT688315 FAM151B family with sequence similarity 151 member B 2 2
MIRT688733 CNDP1 carnosine dipeptidase 1 2 2
MIRT689031 ANGPTL3 angiopoietin like 3 2 2
MIRT698207 TMEM248 transmembrane protein 248 2 2
MIRT699859 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT709954 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT711541 MSH3 mutS homolog 3 2 2
MIRT712077 WDR37 WD repeat domain 37 2 2
MIRT715312 POLR2E RNA polymerase II subunit E 2 2
MIRT715725 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT715748 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT717604 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT717875 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT718042 NIPAL2 NIPA like domain containing 2 2 2
MIRT718829 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT724037 CAMK2N2 calcium/calmodulin dependent protein kinase II inhibitor 2 2 2
MIRT733305 TNF tumor necrosis factor 1 0
MIRT734941 HSPA1B heat shock protein family A (Hsp70) member 1B 3 0
MIRT737343 IGF2 insulin like growth factor 2 3 0
MIRT737546 PTEN phosphatase and tensin homolog 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-23a 1'-Acetoxychavicol acetate (ACA) NULL 119104 Microarray HN4 cell line 24317043 2014 down-regulated
miR-23a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miR-23a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 up-regulated
miR-23a Enoxacin approved 3229 Quantitative real-time PCR HEK293 cells 18641635 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR glandular epithelial cells 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR endometrial stromal 19088369 2008 down-regulated
miR-23a Medroxyprogesterone acetate approved 6279 Quantitative real-time PCR glandular epithelial cells 19088369 2008 up-regulated
miR-23a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
miR-23a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-23a Essential amino acids (EAA) NULL NULL Quantitative real-time PCR skeletal muscle of young adults 19828686 2009 up-regulated
miR-23a Bio-Oss NULL NULL Microarray osteoblast-like cell line (MG63) 20224834 2010 up-regulated
miR-23a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-23a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
miR-23a Trastuzumab approved NULL Microarray BT474 cells 22384020 2012 up-regulated
miR-23a Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Quantitative real-time PCR thymus 23024791 2012 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-23a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 up-regulated
miR-23a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 up-regualted
miR-23a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-23a Comfrey NULL 6440495 Microarray rat liver 21370286 2011 up-regulated
miR-23a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-23a Ethanol NULL 702 Quantitative real-time PCR zebrafish embryos 22298809 2012 down-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-23a Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC-7901)
hsa-mir-23a Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-mir-23a Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-23a Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (OE19)
hsa-mir-23a Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-23a Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-23a Cisplatin 5460033 NSC119875 approved sensitive cell line (SGC-7901)
hsa-miR-23a-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-23a-5p Palbociclib 5330286 NSC758247 approved resistant High Breast Cancer cell line (T47D)
hsa-miR-23a-5p Arsenic trioxide 261004 NSC759274 approved sensitive Low Acute Myeloid Leukemia cell line (U937, Kasumi-1, THP-1, Jurkat E6.1, SUP B15)
hsa-miR-23a-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-23a-5p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-23a-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-23a-5p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-23a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-23a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-23a-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-23a-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-23a-5p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-23a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-23a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-23a-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-23a-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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