miRTarBase - #MIRT639084


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pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ADCYAP1   
Synonyms PACAP
Description adenylate cyclase activating polypeptide 1
Transcript NM_001099733   
Other Transcripts NM_001117   
Expression
Putative miRNA Targets on ADCYAP1
3'UTR of ADCYAP1
(miRNA target sites are highlighted)		 
>ADCYAP1|NM_001099733|3'UTR
   1 CGATGGGTTACCAGCTACCCTGTGTATACAGCCCTGACGCAATGAAAAGTCGTTTTCCAAACTGACTCAACAGTCATCGC
  81 TCGTGTGTTCTATCCAAACATGTATTTATGTAATGAAGTAAAGCCATTAAATGAATATTTTGATAATAATATTGTTTTTC
 161 TTTCTACAAAGCACTAGAGAATGCACAGATATACTTTGTGGACCAATTATTGATATATATTATAAATATATATAAAGAAT
 241 ATATATATATATATATATATATATATATATAAAGTATAGAGAGAAGTTCATACAAAGCGTGCACAAGGATTGAAAATTCG
 321 CCCGAGCTGTTTATGTTTTTATAAAAATAAATAGAAAAGTAGACAATCATTGTTTTGAATATTACTCCTATTTTTGTAAA
 401 CTGGAATTAAAAGGATAGTATTTTTATCCATGACAGGCCTGAAGATATTACTACTTACCATTTGCTACTGTACATAAACA
 481 ATGATGCCCTGCTCCAGGGAGATTTTGAGGTAAAGATATGGAGAATTGCTGAAGGGCATTCTTTCCCAGTGAGTCTCTGG
 561 GGCAGGCTGCTTCAATCCCAGCCTAACTCAACTGGGCTCTGTCCCCCTGGTTGGGTGGCAATTCCAATATTTCTGCTTTC
 641 TTTGATTCTCCTTTTATGTGTAGTTGTCTCTCTTCAGACTCTCAGCCCAGAAGAAAATTCTCCTGATAAAACAACAGCTC
 721 GATCCAAATTGTGCTTCTCCCCAGAATTCACGCCTCTCCCTAGGAGAAGAGTTGAGGAACTGTACAGAAAAGGGCGGCTT
 801 CGTTAGACCGCTCTCTTTTCTGTACTTCCTGAGTGGCCAGGGAATCTAATATCCCCAAATTAGGGCAATTGGAACAAAGT
 881 GAAGGACATAGAGGTATATTGGAAGAGGCAGAGCCTGAGGTGGTAGGAGGAGGACCCTGGAAATGGACTGGTTTGAGATT
 961 GCCCCAGGTCTGGGAAGCTGAGGGCAAATCCAGTCCCAATGGTCCTGACTTTGGGCGCTGGGTATTGGAAATGGATGCAA
1041 AGTACAATGTGTTTTTCTCCAGTGCTGTCCATGCTTCTCATCTTGTGAAATGGCCAGGATCCTCTCCTTTGAAACCTGCT
1121 CTGTAGGAGCTACCCTTTTCCTTTGTGGTTTTATGGAGACCTCTCCTTCCTACCCTCCTGCACTGTTTAAGTACTGTTTA
1201 CCATTTTTCATTCACTTCTCTTAAACTTGTGAATGCTTCTCACTTTTTTTTTTTGTTTGATGCAGGCACTTATTGTAAAT
1281 TTTAGAAACCCCTCTGTAGCCACTAGTAAGTAATTATGCACTAAATATGAACCCTTTGTTTCTTGTTTATTGAGTTTGTA
1361 GGTAAAATGTATTTTTCTACATTATTGCTTATTGCTTAGTAAAATTTATTTCATAAAACCAACCTTTGTCATATTAGAAT
1441 GTGTAGTGTTCACATGTTGCTCAGTTTTGCTAACTGATAAATCATTTAATCCTCTTCTTCATATGTATGAGTACTATCTT
1521 ATATCTGTGGTCAAGAGTGAGGTAAGCAAGCTCCAACAGACCCTGAGAACCTACGCTTGTATCCTTTCTTTGGCTAAAGA
1601 AAGCATGTCTGTTTCCTGTCAATTCTTTGAACATACAGAGTAATCTTTATAAACAAAAGAACCTTCACCCAGCAATCAGA
1681 TCGAGCAGCAACAGACAAACCAGCCAGCCAATCTCCCAAATTTCAGGCACAAGTTTATTTATTTATTTTTTTATGTTTTG
1761 AAAAAAGAAGATGAAGAAGAAGAAAAAAAAAAGAACAAGGAAAGATTAAACGTTAGCTTGTAAAGTTTAAAGGACCTTTC
1841 CTTTTCCTTTACGGATTTGATCAGTATGAAGTCATAAATCAAAGAAAACAGAATTGGATTTGCATTCCCAGGCGGGATGG
1921 ATGCTGCCAGGAGATCACATTGCAAATAGTGAAAACAGAGGCATTCGGTCTATGCCTGAGTCCTGTGTATAGGATCAATC
2001 TTCCTTTAATTCCGCAGTCTCCTCAGGCAATGTGACACGGGATGCAGTTTGCAGCTTTAGTGCCTTTCTTCGCCTTTTAA
2081 ATTGCCACGAATCACAGATGGCTATTTAGTGGCCCTACAATGCTGCAACACATCAGCTTGCATTTTAGTCTTAATTATTT
2161 GTTTCTTGGATAATGGGCAGAGTTTTCTGTATTTGTATCAGCTGTTAGTGGTGAAATAGGGCTCTAGTTAACCTTTTATT
2241 TATGAAGTCTAATTTAGTGTTCCCGTGGCTAGTTGCAAGCATTTTACAGTGATCACCCAGTTTAATCTTTTGTATACTTT
2321 TTAGAAATGCCAAGAGCCTTACTAAACTGAAGCAGATTTATGATATAGTGATAATTTAGGTAGATGTTAGTCTTGAAGCT
2401 CTTATTTTGTGTGCAACTGATTATAAAAACACCTTAACCAAGTATTATTACACACATGATATCTATAACTAGGACTTTGA
2481 TAACTGTTATATAAAGTGTGTAAAATTTGTATGAATAAATTTTTGTAAACAATGCAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guGAAUGAAGAAAC--GUC-UACUc 5'
            :||||   ||||  ||| |||| 
Target 5' ccTTTACGGATTTGATCAGTATGAa 3'
 1846 - 1870 130.00 -8.20
2 
miRNA  3' gugAAUGAAG--AAACGUCUACUc 5'
             ||:|  |   |  ||||||: 
Target 5' aaaTTGCCACGAATCACAGATGGc 3'
 2079 - 2102 125.00 -8.10
3 
miRNA  3' guGAAUGAAGAA------ACGUCUACUc 5'
            :|||: |:||       | |||||| 
Target 5' ttTTTATGTTTTGAAAAAAGAAGATGAa 3'
 1748 - 1775 122.00 -6.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13776145 3 COSMIC
COSN26965206 9 COSMIC
COSN18741433 32 COSMIC
COSN30170450 39 COSMIC
COSN30495334 40 COSMIC
COSN31587749 40 COSMIC
COSN30183866 52 COSMIC
COSN20079202 53 COSMIC
COSN1759852 57 COSMIC
COSN28193747 60 COSMIC
COSN506823 81 COSMIC
COSN31496906 84 COSMIC
COSN2528534 116 COSMIC
COSN30527170 137 COSMIC
COSN19292792 253 COSMIC
COSN18768065 259 COSMIC
COSN19138572 426 COSMIC
COSN27944809 504 COSMIC
COSN8255957 752 COSMIC
COSN8551996 804 COSMIC
COSN21216502 1168 COSMIC
COSN20114594 1255 COSMIC
COSN24476765 1256 COSMIC
COSN21816253 1537 COSMIC
COSN26710510 1566 COSMIC
COSN19368909 1660 COSMIC
COSN19368910 1680 COSMIC
COSN20114596 1742 COSMIC
COSN20114600 1745 COSMIC
COSN32062106 1745 COSMIC
COSN19368911 1761 COSMIC
COSN20114604 1793 COSMIC
COSN19368912 1860 COSMIC
COSN23062779 2139 COSMIC
COSN23380653 2201 COSMIC
COSN25739072 2371 COSMIC
COSN21109464 2439 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773391223 2 dbSNP
rs1226061114 5 dbSNP
rs756839865 7 dbSNP
rs760845880 8 dbSNP
rs753893246 10 dbSNP
rs1250802443 12 dbSNP
rs1479717483 16 dbSNP
rs113395599 18 dbSNP
rs1251177234 19 dbSNP
rs778411412 22 dbSNP
rs753198961 24 dbSNP
rs745357671 26 dbSNP
rs1308199773 27 dbSNP
rs190047341 29 dbSNP
rs369093915 30 dbSNP
rs2231188 32 dbSNP
rs2231189 34 dbSNP
rs755782905 35 dbSNP
rs905475767 36 dbSNP
rs779865858 38 dbSNP
rs748766669 39 dbSNP
rs768119719 40 dbSNP
rs1311416030 41 dbSNP
rs1213704003 43 dbSNP
rs1461008139 43 dbSNP
rs369091160 44 dbSNP
rs1234089253 46 dbSNP
rs1295155865 49 dbSNP
rs772027382 52 dbSNP
rs984952573 53 dbSNP
rs1165205234 58 dbSNP
rs909405909 59 dbSNP
rs1248655028 63 dbSNP
rs1176857428 72 dbSNP
rs2231190 76 dbSNP
rs951441034 77 dbSNP
rs975006882 80 dbSNP
rs1016852159 83 dbSNP
rs1315537449 84 dbSNP
rs549866484 94 dbSNP
rs1390476108 95 dbSNP
rs920917895 96 dbSNP
rs1182962521 111 dbSNP
rs1402626370 113 dbSNP
rs933654987 115 dbSNP
rs921167647 127 dbSNP
rs1235004647 129 dbSNP
rs1459217080 130 dbSNP
rs1361860742 132 dbSNP
rs1158567143 142 dbSNP
rs1473037612 143 dbSNP
rs1050833798 150 dbSNP
rs924347598 162 dbSNP
rs1197334947 173 dbSNP
rs1470938320 175 dbSNP
rs934451577 178 dbSNP
rs1161309096 184 dbSNP
rs1490218118 186 dbSNP
rs1268618414 187 dbSNP
rs1054205195 204 dbSNP
rs1212175973 208 dbSNP
rs1485064149 218 dbSNP
rs892986328 219 dbSNP
rs1240294599 225 dbSNP
rs1384017470 226 dbSNP
rs956354978 226 dbSNP
rs1289887727 233 dbSNP
rs1221123411 238 dbSNP
rs1334279286 238 dbSNP
rs1404786191 238 dbSNP
rs1201417237 239 dbSNP
rs1201561543 239 dbSNP
rs1269589871 239 dbSNP
rs1344359699 239 dbSNP
rs1378292000 239 dbSNP
rs1407604073 239 dbSNP
rs1466564107 239 dbSNP
rs147221355 239 dbSNP
rs1480123062 239 dbSNP
rs35018620 239 dbSNP
rs527307010 239 dbSNP
rs549818617 239 dbSNP
rs570910309 239 dbSNP
rs67164633 239 dbSNP
rs769236469 239 dbSNP
rs773073282 239 dbSNP
rs774997307 239 dbSNP
rs1274917691 240 dbSNP
rs989900271 240 dbSNP
rs1424754985 241 dbSNP
rs1165009260 243 dbSNP
rs1368621368 247 dbSNP
rs62080098 249 dbSNP
rs1329259032 250 dbSNP
rs1337338993 254 dbSNP
rs1446023262 255 dbSNP
rs1314647553 256 dbSNP
rs1294817032 257 dbSNP
rs1435490608 258 dbSNP
rs866729304 259 dbSNP
rs1469487534 261 dbSNP
rs868670641 261 dbSNP
rs1403263106 262 dbSNP
rs1460575234 263 dbSNP
rs182226418 263 dbSNP
rs1383530840 264 dbSNP
rs1248256319 265 dbSNP
rs1003276926 266 dbSNP
rs1451669940 267 dbSNP
rs866579116 267 dbSNP
rs1272641803 268 dbSNP
rs1026351663 269 dbSNP
rs1183431310 269 dbSNP
rs1339271923 271 dbSNP
rs950845604 271 dbSNP
rs1201640292 272 dbSNP
rs1006340569 273 dbSNP
rs1016413443 274 dbSNP
rs1196919382 275 dbSNP
rs1273762581 277 dbSNP
rs964894991 278 dbSNP
rs1312640089 280 dbSNP
rs974952933 281 dbSNP
rs1275496288 282 dbSNP
rs923526338 282 dbSNP
rs887280913 287 dbSNP
rs1004377750 288 dbSNP
rs955019105 291 dbSNP
rs986870649 293 dbSNP
rs28517455 300 dbSNP
rs934381437 301 dbSNP
rs989876868 309 dbSNP
rs1163313575 319 dbSNP
rs1028343264 320 dbSNP
rs1237653532 323 dbSNP
rs187183412 325 dbSNP
rs1444928120 327 dbSNP
rs767086953 335 dbSNP
rs1205334760 353 dbSNP
rs948562103 354 dbSNP
rs547640489 355 dbSNP
rs1227502138 359 dbSNP
rs1356827173 361 dbSNP
rs1286130309 367 dbSNP
rs986723062 382 dbSNP
rs1370881938 392 dbSNP
rs907110216 393 dbSNP
rs1461382165 399 dbSNP
rs1411795943 401 dbSNP
rs1364217953 416 dbSNP
rs1031468207 418 dbSNP
rs955854192 419 dbSNP
rs565862612 435 dbSNP
rs948519212 446 dbSNP
rs1468278948 449 dbSNP
rs980149218 461 dbSNP
rs142179366 468 dbSNP
rs114962297 470 dbSNP
rs1266638318 471 dbSNP
rs1220775559 478 dbSNP
rs1451912957 480 dbSNP
rs1291773940 482 dbSNP
rs9959930 483 dbSNP
rs1289258764 488 dbSNP
rs1230257181 489 dbSNP
rs1295448376 498 dbSNP
rs887395090 504 dbSNP
rs1325954904 508 dbSNP
rs1437824772 512 dbSNP
rs940179127 513 dbSNP
rs1272434887 516 dbSNP
rs150841751 516 dbSNP
rs1038526383 518 dbSNP
rs1387423285 521 dbSNP
rs1159471053 522 dbSNP
rs1203422740 530 dbSNP
rs898550980 537 dbSNP
rs764494788 539 dbSNP
rs773442983 545 dbSNP
rs1461466696 556 dbSNP
rs900638545 561 dbSNP
rs1478305250 562 dbSNP
rs1205207075 568 dbSNP
rs1258993614 570 dbSNP
rs996338603 579 dbSNP
rs996954215 592 dbSNP
rs1210828631 595 dbSNP
rs1321434522 596 dbSNP
rs1193727778 598 dbSNP
rs1219957007 607 dbSNP
rs1030539714 615 dbSNP
rs1028707178 623 dbSNP
rs955111876 634 dbSNP
rs1366412157 636 dbSNP
rs978379611 637 dbSNP
rs1175413594 645 dbSNP
rs1031729457 650 dbSNP
rs1429777735 658 dbSNP
rs555061886 660 dbSNP
rs1287350294 663 dbSNP
rs955708731 666 dbSNP
rs1382846997 692 dbSNP
rs1248427741 693 dbSNP
rs1190337980 698 dbSNP
rs1460147727 706 dbSNP
rs139318048 707 dbSNP
rs1320440731 709 dbSNP
rs989824454 716 dbSNP
rs1210878306 719 dbSNP
rs1344151587 721 dbSNP
rs914313068 722 dbSNP
rs149971122 725 dbSNP
rs980322795 733 dbSNP
rs955967817 734 dbSNP
rs1450996005 735 dbSNP
rs1376496642 741 dbSNP
rs1301923369 742 dbSNP
rs989962314 747 dbSNP
rs1448077913 752 dbSNP
rs560349494 753 dbSNP
rs928517655 758 dbSNP
rs1166578691 759 dbSNP
rs1429013217 761 dbSNP
rs1485378560 770 dbSNP
rs1205190532 773 dbSNP
rs1170215872 778 dbSNP
rs1421886400 782 dbSNP
rs71352971 784 dbSNP
rs1489830020 785 dbSNP
rs545959592 786 dbSNP
rs1047661521 794 dbSNP
rs774685836 796 dbSNP
rs114060579 803 dbSNP
rs979880162 809 dbSNP
rs564448196 811 dbSNP
rs1244182335 812 dbSNP
rs928414124 816 dbSNP
rs1311487829 818 dbSNP
rs571424258 819 dbSNP
rs1037740469 820 dbSNP
rs550194967 823 dbSNP
rs908781182 824 dbSNP
rs940296217 826 dbSNP
rs1456161221 834 dbSNP
rs1367681578 835 dbSNP
rs1165673500 843 dbSNP
rs996300288 847 dbSNP
rs1038914852 850 dbSNP
rs561911561 852 dbSNP
rs1472974699 855 dbSNP
rs1254547577 863 dbSNP
rs1220914340 867 dbSNP
rs890646991 870 dbSNP
rs1454550702 875 dbSNP
rs920113054 876 dbSNP
rs1000146897 879 dbSNP
rs1286123799 880 dbSNP
rs879034111 881 dbSNP
rs758438432 885 dbSNP
rs1290061084 888 dbSNP
rs1385018141 892 dbSNP
rs1049832391 894 dbSNP
rs780172359 899 dbSNP
rs529421778 900 dbSNP
rs1459282211 901 dbSNP
rs1386670588 902 dbSNP
rs1158750442 905 dbSNP
rs1457778387 909 dbSNP
rs1363827867 915 dbSNP
rs1196922530 920 dbSNP
rs115067101 926 dbSNP
rs958314788 927 dbSNP
rs1011191397 929 dbSNP
rs1006567 933 dbSNP
rs1265806545 940 dbSNP
rs1390025287 950 dbSNP
rs891691437 952 dbSNP
rs1269462917 955 dbSNP
rs1011509170 956 dbSNP
rs1330412438 957 dbSNP
rs1301951226 958 dbSNP
rs969764928 965 dbSNP
rs533162363 967 dbSNP
rs1261922085 969 dbSNP
rs1320075734 970 dbSNP
rs1021839559 981 dbSNP
rs1170863197 983 dbSNP
rs1221568377 984 dbSNP
rs1465651572 998 dbSNP
rs1610037 1000 dbSNP
rs1178909345 1010 dbSNP
rs928435776 1017 dbSNP
rs1447971188 1018 dbSNP
rs191206837 1020 dbSNP
rs1249609650 1027 dbSNP
rs1263453853 1029 dbSNP
rs1035432744 1032 dbSNP
rs959805848 1036 dbSNP
rs1256452245 1042 dbSNP
rs566156608 1043 dbSNP
rs983055051 1058 dbSNP
rs1184274901 1061 dbSNP
rs1296595146 1062 dbSNP
rs1383396990 1063 dbSNP
rs983740930 1072 dbSNP
rs1424100647 1075 dbSNP
rs1367595500 1085 dbSNP
rs1164364712 1088 dbSNP
rs182254448 1095 dbSNP
rs185441467 1097 dbSNP
rs1403006212 1111 dbSNP
rs1460961113 1116 dbSNP
rs1428365796 1121 dbSNP
rs941966267 1127 dbSNP
rs764602370 1131 dbSNP
rs1451769948 1133 dbSNP
rs974354487 1136 dbSNP
rs1184971528 1138 dbSNP
rs567136537 1141 dbSNP
rs1394889517 1143 dbSNP
rs749090271 1147 dbSNP
rs1212486824 1166 dbSNP
rs932826134 1167 dbSNP
rs1273894714 1176 dbSNP
rs1050374753 1177 dbSNP
rs1391552155 1178 dbSNP
rs140753323 1183 dbSNP
rs932035606 1184 dbSNP
rs1244347919 1191 dbSNP
rs944119832 1196 dbSNP
rs1336238255 1202 dbSNP
rs1408119152 1234 dbSNP
rs1051858577 1235 dbSNP
rs1370456682 1236 dbSNP
rs1380207919 1237 dbSNP
rs1244586703 1238 dbSNP
rs753365616 1239 dbSNP
rs1389045882 1242 dbSNP
rs1291936866 1243 dbSNP
rs1368726246 1244 dbSNP
rs1471337019 1244 dbSNP
rs34903313 1244 dbSNP
rs398031826 1244 dbSNP
rs1250934993 1245 dbSNP
rs1323404305 1255 dbSNP
rs771045869 1256 dbSNP
rs774282779 1257 dbSNP
rs1053076578 1259 dbSNP
rs1250505715 1259 dbSNP
rs1480842514 1260 dbSNP
rs1197703220 1261 dbSNP
rs1241520723 1263 dbSNP
rs1226594409 1265 dbSNP
rs1349980945 1266 dbSNP
rs1289466379 1268 dbSNP
rs1444979077 1270 dbSNP
rs1444295336 1273 dbSNP
rs891806525 1275 dbSNP
rs1161620959 1285 dbSNP
rs1184262719 1290 dbSNP
rs1406368560 1291 dbSNP
rs1390946918 1294 dbSNP
rs1166685397 1300 dbSNP
rs1455126146 1302 dbSNP
rs1410601122 1305 dbSNP
rs1182341897 1310 dbSNP
rs1387202442 1311 dbSNP
rs890585055 1315 dbSNP
rs1197871027 1318 dbSNP
rs1170377480 1333 dbSNP
rs1355414674 1334 dbSNP
rs552671731 1337 dbSNP
rs1275234515 1339 dbSNP
rs999690988 1370 dbSNP
rs1328820060 1380 dbSNP
rs1463849820 1384 dbSNP
rs1052589783 1387 dbSNP
rs1268850419 1389 dbSNP
rs1335213472 1389 dbSNP
rs1225580902 1391 dbSNP
rs1366086101 1392 dbSNP
rs1403417678 1393 dbSNP
rs1451520031 1394 dbSNP
rs894040605 1398 dbSNP
rs1315092386 1401 dbSNP
rs535170260 1420 dbSNP
rs1373654892 1421 dbSNP
rs1021215698 1422 dbSNP
rs1042972162 1442 dbSNP
rs1212673428 1453 dbSNP
rs969715661 1456 dbSNP
rs1001654675 1459 dbSNP
rs905804984 1466 dbSNP
rs1035455418 1470 dbSNP
rs960094356 1478 dbSNP
rs1387538300 1485 dbSNP
rs1159218960 1489 dbSNP
rs1401983311 1492 dbSNP
rs1001357318 1495 dbSNP
rs756711868 1498 dbSNP
rs1035951519 1502 dbSNP
rs983302547 1504 dbSNP
rs1478193351 1508 dbSNP
rs1308070616 1512 dbSNP
rs1254637783 1514 dbSNP
rs1200286130 1517 dbSNP
rs907734257 1518 dbSNP
rs963279139 1522 dbSNP
rs758970417 1527 dbSNP
rs1186515753 1536 dbSNP
rs959753618 1539 dbSNP
rs973336005 1552 dbSNP
rs1261076447 1566 dbSNP
rs1310549170 1572 dbSNP
rs1014503595 1573 dbSNP
rs921888114 1575 dbSNP
rs62080099 1576 dbSNP
rs1027224334 1577 dbSNP
rs1052232555 1584 dbSNP
rs774842695 1585 dbSNP
rs912745358 1596 dbSNP
rs944067301 1598 dbSNP
rs935434751 1606 dbSNP
rs546028753 1616 dbSNP
rs1166464765 1619 dbSNP
rs893988238 1620 dbSNP
rs190166278 1621 dbSNP
rs988893284 1629 dbSNP
rs1188513252 1631 dbSNP
rs182760479 1633 dbSNP
rs188534866 1635 dbSNP
rs1001203323 1639 dbSNP
rs1210991720 1645 dbSNP
rs1174694305 1649 dbSNP
rs1429069562 1653 dbSNP
rs191633083 1664 dbSNP
rs1273166236 1668 dbSNP
rs1228058136 1670 dbSNP
rs1343350338 1673 dbSNP
rs1295759078 1674 dbSNP
rs895548827 1683 dbSNP
rs1004665454 1684 dbSNP
rs1014738024 1685 dbSNP
rs1306142039 1687 dbSNP
rs1043476277 1691 dbSNP
rs1354910743 1691 dbSNP
rs1172344624 1693 dbSNP
rs1422278880 1694 dbSNP
rs963209795 1695 dbSNP
rs543742180 1697 dbSNP
rs867575248 1698 dbSNP
rs905756979 1701 dbSNP
rs973281181 1702 dbSNP
rs562370678 1705 dbSNP
rs937269332 1712 dbSNP
rs529290910 1713 dbSNP
rs878908605 1720 dbSNP
rs1362541428 1726 dbSNP
rs1220435560 1730 dbSNP
rs1281093092 1734 dbSNP
rs1288735381 1736 dbSNP
rs1322580739 1737 dbSNP
rs1356819909 1738 dbSNP
rs1409122551 1738 dbSNP
rs1224287202 1739 dbSNP
rs1299637360 1739 dbSNP
rs1491380657 1740 dbSNP
rs66502625 1741 dbSNP
rs755821617 1741 dbSNP
rs761679222 1741 dbSNP
rs2846813 1742 dbSNP
rs752114264 1742 dbSNP
rs1420176652 1743 dbSNP
rs1491053538 1744 dbSNP
rs111646130 1745 dbSNP
rs1438493438 1745 dbSNP
rs201215318 1745 dbSNP
rs1314768609 1746 dbSNP
rs2689003 1746 dbSNP
rs60372265 1746 dbSNP
rs1213943723 1753 dbSNP
rs1242820998 1753 dbSNP
rs1489536625 1754 dbSNP
rs1197920577 1756 dbSNP
rs1268557576 1760 dbSNP
rs1317419664 1761 dbSNP
rs1214559238 1765 dbSNP
rs1480969062 1768 dbSNP
rs1179113800 1769 dbSNP
rs1426809258 1771 dbSNP
rs1366646196 1772 dbSNP
rs1158496291 1773 dbSNP
rs1326758102 1773 dbSNP
rs1386781185 1773 dbSNP
rs1398639694 1774 dbSNP
rs1157694914 1777 dbSNP
rs1345302448 1780 dbSNP
rs1195969086 1783 dbSNP
rs1432908496 1783 dbSNP
rs371204243 1783 dbSNP
rs540059614 1783 dbSNP
rs1401711690 1784 dbSNP
rs1004711619 1785 dbSNP
rs183868799 1786 dbSNP
rs898947142 1787 dbSNP
rs1405317967 1789 dbSNP
rs1276448362 1793 dbSNP
rs1311588498 1806 dbSNP
rs1303868009 1812 dbSNP
rs994494394 1813 dbSNP
rs1348771271 1817 dbSNP
rs1363234773 1826 dbSNP
rs557605185 1828 dbSNP
rs1382788224 1830 dbSNP
rs1387250765 1832 dbSNP
rs1301230607 1837 dbSNP
rs954290555 1848 dbSNP
rs551651277 1853 dbSNP
rs1355966301 1854 dbSNP
rs1448068322 1860 dbSNP
rs754259590 1862 dbSNP
rs987469647 1872 dbSNP
rs1192030471 1874 dbSNP
rs1428529178 1875 dbSNP
rs911908004 1895 dbSNP
rs1263199150 1896 dbSNP
rs965529943 1903 dbSNP
rs569731679 1908 dbSNP
rs530870488 1912 dbSNP
rs1485293080 1913 dbSNP
rs935399397 1914 dbSNP
rs988201470 1915 dbSNP
rs1490672369 1916 dbSNP
rs1269768068 1917 dbSNP
rs1228414420 1922 dbSNP
rs913302688 1924 dbSNP
rs915372750 1936 dbSNP
rs1395573156 1938 dbSNP
rs946896097 1939 dbSNP
rs1376543226 1941 dbSNP
rs1045243472 1947 dbSNP
rs905441516 1948 dbSNP
rs927293510 1954 dbSNP
rs937234643 1962 dbSNP
rs1168908931 1967 dbSNP
rs549024803 1968 dbSNP
rs1380314162 1974 dbSNP
rs1184721808 1983 dbSNP
rs1056788090 1987 dbSNP
rs569777191 1994 dbSNP
rs1161195711 1995 dbSNP
rs1364864075 1996 dbSNP
rs1425267210 1998 dbSNP
rs567524138 2001 dbSNP
rs1272019086 2002 dbSNP
rs895770322 2006 dbSNP
rs866602673 2009 dbSNP
rs1014689002 2010 dbSNP
rs898949271 2014 dbSNP
rs144512876 2015 dbSNP
rs1280366914 2022 dbSNP
rs1379476207 2023 dbSNP
rs995006006 2028 dbSNP
rs79120479 2031 dbSNP
rs1314514282 2033 dbSNP
rs112124379 2040 dbSNP
rs987804771 2041 dbSNP
rs1412022117 2042 dbSNP
rs765671061 2044 dbSNP
rs888780178 2050 dbSNP
rs1460418730 2052 dbSNP
rs956710185 2062 dbSNP
rs538322808 2064 dbSNP
rs533964047 2072 dbSNP
rs1019866979 2073 dbSNP
rs576574587 2074 dbSNP
rs915320534 2075 dbSNP
rs946843797 2079 dbSNP
rs1232282636 2082 dbSNP
rs192669197 2089 dbSNP
rs545771326 2090 dbSNP
rs926813602 2093 dbSNP
rs552579237 2098 dbSNP
rs1265450015 2099 dbSNP
rs939591262 2101 dbSNP
rs1335795498 2103 dbSNP
rs1057138505 2106 dbSNP
rs895447497 2119 dbSNP
rs1473059284 2133 dbSNP
rs1350561119 2134 dbSNP
rs1010387369 2148 dbSNP
rs1444737391 2164 dbSNP
rs1329728214 2166 dbSNP
rs940329955 2175 dbSNP
rs1020478233 2176 dbSNP
rs1439703200 2177 dbSNP
rs1394815147 2183 dbSNP
rs968799037 2184 dbSNP
rs555784717 2190 dbSNP
rs1036068952 2210 dbSNP
rs1455211512 2216 dbSNP
rs1164947314 2218 dbSNP
rs898897021 2221 dbSNP
rs979256667 2225 dbSNP
rs927439595 2240 dbSNP
rs958948147 2241 dbSNP
rs1469049443 2244 dbSNP
rs574231227 2247 dbSNP
rs1255179561 2254 dbSNP
rs758432097 2258 dbSNP
rs1446506740 2260 dbSNP
rs780228637 2264 dbSNP
rs538328852 2265 dbSNP
rs559783113 2266 dbSNP
rs368093870 2267 dbSNP
rs1235542395 2271 dbSNP
rs917143816 2280 dbSNP
rs1383646181 2281 dbSNP
rs1247547296 2294 dbSNP
rs572603416 2297 dbSNP
rs1050239217 2298 dbSNP
rs888963664 2311 dbSNP
rs1008773799 2317 dbSNP
rs1260441985 2320 dbSNP
rs940629246 2323 dbSNP
rs1036123769 2331 dbSNP
rs1201415720 2344 dbSNP
rs920429251 2346 dbSNP
rs545505193 2349 dbSNP
rs1172757453 2352 dbSNP
rs541482158 2354 dbSNP
rs1050593546 2367 dbSNP
rs1442505263 2368 dbSNP
rs781546684 2372 dbSNP
rs1371249880 2381 dbSNP
rs956657794 2383 dbSNP
rs1475069198 2384 dbSNP
rs1475242421 2385 dbSNP
rs1171084908 2399 dbSNP
rs1218093515 2403 dbSNP
rs1008552170 2410 dbSNP
rs1280271113 2412 dbSNP
rs1211997382 2416 dbSNP
rs1350506231 2417 dbSNP
rs1305096794 2420 dbSNP
rs1212422265 2425 dbSNP
rs992434631 2434 dbSNP
rs1270239842 2445 dbSNP
rs1009523008 2457 dbSNP
rs563769429 2461 dbSNP
rs141319752 2470 dbSNP
rs1312205809 2474 dbSNP
rs1435041860 2485 dbSNP
rs749108643 2488 dbSNP
rs1377036005 2491 dbSNP
rs1168139554 2493 dbSNP
rs1409578058 2494 dbSNP
rs1010500543 2501 dbSNP
rs1336335341 2506 dbSNP
rs1020411968 2508 dbSNP
rs981277509 2513 dbSNP
rs1402920997 2517 dbSNP
rs1189282006 2536 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000579794.1 | 3UTR | UUUUGAAAAAAGAAGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE14794 Lymphoblastoid cells 0.302 1.9e-3 0.314 1.3e-3 90 Click to see details
GSE28260 Renal cortex and medulla 0.557 2.4e-2 0.604 1.4e-2 13 Click to see details
GSE26953 Aortic valvular endothelial cells -0.32 6.4e-2 0.110 3.0e-1 24 Click to see details
GSE38226 Liver fibrosis 0.311 8.5e-2 0.304 9.0e-2 21 Click to see details
GSE42095 Differentiated embryonic stem cells 0.264 1.1e-1 0.028 4.5e-1 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.275 1.2e-1 -0.095 3.5e-1 20 Click to see details
GSE27834 Pluripotent stem cells -0.198 2.3e-1 -0.021 4.7e-1 16 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.139 2.5e-1 0.328 5.5e-2 25 Click to see details
GSE17498 Multiple myeloma -0.102 2.7e-1 -0.056 3.7e-1 40 Click to see details
GSE21687 Ependynoma primary tumors -0.067 3.0e-1 -0.051 3.4e-1 64 Click to see details
GSE32688 Pancreatic cancer -0.065 3.6e-1 -0.081 3.3e-1 32 Click to see details
GSE28544 Breast cancer -0.072 3.7e-1 -0.178 2.0e-1 24 Click to see details
GSE21849 B cell lymphoma 0.058 3.8e-1 0.266 8.2e-2 29 Click to see details
GSE19350 CNS germ cell tumors -0.059 4.3e-1 0.364 1.2e-1 12 Click to see details
GSE17306 Multiple myeloma -0.005 4.9e-1 0.465 3.8e-4 49 Click to see details
GSE17306 Multiple myeloma -0.005 4.9e-1 0.465 3.8e-4 49 Click to see details
GSE17306 Multiple myeloma -0.005 4.9e-1 0.465 3.8e-4 49 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.24 0.02 0.288 0.01 79 Click to see details
STAD -0.389 0.02 -0.374 0.02 29 Click to see details
PRAD -0.268 0.03 -0.357 0.01 48 Click to see details
LUAD -0.393 0.12 -0.336 0.16 11 Click to see details
ESCA -0.379 0.16 -0.250 0.26 9 Click to see details
CHOL 0.318 0.2 0.250 0.26 9 Click to see details
THCA -0.106 0.21 -0.123 0.18 59 Click to see details
LIHC -0.111 0.22 -0.141 0.17 49 Click to see details
PAAD -0.533 0.23 -0.400 0.3 4 Click to see details
HNSC -0.099 0.27 -0.107 0.25 42 Click to see details
KICH 0.129 0.27 0.090 0.34 24 Click to see details
CESC 0.582 0.3 0.500 0.33 3 Click to see details
LUSC -0.03 0.43 -0.062 0.36 38 Click to see details
BLCA 0.045 0.43 0.206 0.21 17 Click to see details
UCEC -0.041 0.43 -0.079 0.37 19 Click to see details
KIRC 0.009 0.47 0.032 0.4 65 Click to see details
KIRP 0.003 0.49 0.117 0.27 31 Click to see details
KIRP 0.003 0.49 0.117 0.27 31 Click to see details
KIRP 0.003 0.49 0.117 0.27 31 Click to see details
KIRP 0.003 0.49 0.117 0.27 31 Click to see details
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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