pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NINJ1   
Synonyms NIN1, NINJURIN
Description ninjurin 1
Transcript NM_004148   
Expression
Putative miRNA Targets on NINJ1
3'UTR of NINJ1
(miRNA target sites are highlighted)
>NINJ1|NM_004148|3'UTR
   1 GACACCCAGGACCCTGGATGCTGCCTGCCCTGCAACTCAGCTGCCCGACCCCAGGAGTCGCCATACCTGTGAGGTGTCCA
  81 CCTCCCTGCACATGGCACTACCCAGACTGCCAGAGCCCAGGCTGGCCTCATCTGCACCATGTCCCCGGACCAGCCCTTGC
 161 TCTGACTGCGGCCAAGCACCACGCAGGAGGCCACTCTTGTCTCTCAGCAGCTGTTCCCAGGAGGCAGCTCCCTCCTGGCA
 241 CATGGGGGCTGGCCACAATAGCCCAGAGGGTCAGAACTGGACAGCTGCAGAGACCTGTGCCCAGAGAAGGGTCTCGACCC
 321 ACTCAAGGACACACAGCAGGTCCGTGGATGGGCTGGATGAGTGACCAGGGCCAGCCTCTGTCTCAGGACATTCCAGAAGG
 401 ACAAGGAGATGTCTCTCCCTCTCCCAAAGCACCAGCGTCCCTGCCTCCCGTGGGCCCTGTCCGGGTTGCCCTGGTGACCC
 481 CAGCCTCTGTCCACTTCCTAACCCAGGGACCCTGCACAGCCAGAACTGCCTTTGGCCCTACGGATGGCCACTGGCTCTGG
 561 TCTTAAGTGCCTGGGCTTGGTGGCCATCAAGAGGGAGCCAGTCAGGCCTGTGAGGGCCGTAGACCTTGTATATACCCTGC
 641 ACCAGCAGTGACCGGGCAGAGCCCAACCCCCTCCACGGGGGTCCCAGCACCCACTTTTCTAATCATGAATGAACAATAAA
 721 GCCCACGCTCTTTGTCAGGCTCCACATGCCAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gugaaUGA-AGAAAC------GUCUACUc 5'
               |||  |||||      |:||||: 
Target 5' ccagaACTGCCTTTGGCCCTACGGATGGc 3'
520 - 548 119.00 -10.20
2
miRNA  3' guGAAUGAAGAAACGUCUACuc 5'
            |||:: |||  |||| ||  
Target 5' ctCTTGTCTCTCAGCAGCTGtt 3'
194 - 215 116.00 -11.10
3
miRNA  3' gugaaUGAAGAAACGUCUACUc 5'
               || ||  |||| |||: 
Target 5' tgtccACCTCCCTGCACATGGc 3'
75 - 96 113.00 -6.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31504024 1 COSMIC
COSN20065296 30 COSMIC
COSN28795281 36 COSMIC
COSN19666936 61 COSMIC
COSN28796491 82 COSMIC
COSN5708230 223 COSMIC
COSN24196736 700 COSMIC
COSN32020868 1110 COSMIC
COSN14779827 1139 COSMIC
COSN27438062 1608 COSMIC
COSN30032948 1748 COSMIC
COSN17484233 1899 COSMIC
COSN23324170 1953 COSMIC
COSN1382986 2412 COSMIC
COSN22018064 2438 COSMIC
COSN9287846 2515 COSMIC
COSN17416976 2534 COSMIC
COSN18758541 2552 COSMIC
COSN17416614 2564 COSMIC
COSN18856858 2594 COSMIC
rs7033638 3405 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs779583502 4 dbSNP
rs201508523 12 dbSNP
rs112602538 17 dbSNP
rs1314802054 21 dbSNP
rs368939746 22 dbSNP
rs756911664 23 dbSNP
rs753593126 27 dbSNP
rs760640137 28 dbSNP
rs199837093 29 dbSNP
rs370312075 30 dbSNP
rs191154538 31 dbSNP
rs1184051739 34 dbSNP
rs13298119 36 dbSNP
rs1388485275 37 dbSNP
rs1046140337 40 dbSNP
rs777112184 48 dbSNP
rs1016386676 49 dbSNP
rs764708088 54 dbSNP
rs908225161 56 dbSNP
rs561305331 59 dbSNP
rs1054985728 69 dbSNP
rs867525109 74 dbSNP
rs186754320 80 dbSNP
rs13299270 82 dbSNP
rs906480450 94 dbSNP
rs114674792 96 dbSNP
rs575637026 97 dbSNP
rs1286558972 98 dbSNP
rs1217693218 103 dbSNP
rs945102243 110 dbSNP
rs1019004047 113 dbSNP
rs1324995124 114 dbSNP
rs913561604 119 dbSNP
rs1277795270 121 dbSNP
rs987566378 122 dbSNP
rs772317448 126 dbSNP
rs1217709660 132 dbSNP
rs746080333 133 dbSNP
rs1010933571 135 dbSNP
rs1191708383 145 dbSNP
rs1275866322 155 dbSNP
rs573773828 170 dbSNP
rs1431617638 177 dbSNP
rs893704739 180 dbSNP
rs1339144314 183 dbSNP
rs1423657276 190 dbSNP
rs1297021054 192 dbSNP
rs1033594602 194 dbSNP
rs1001952040 197 dbSNP
rs1361940658 205 dbSNP
rs542923615 206 dbSNP
rs1399023931 209 dbSNP
rs1295945769 211 dbSNP
rs1346893510 212 dbSNP
rs1223571164 213 dbSNP
rs1273684564 226 dbSNP
rs1342827886 230 dbSNP
rs1225329175 234 dbSNP
rs561773219 240 dbSNP
rs1173440112 241 dbSNP
rs1214810458 244 dbSNP
rs1271278577 245 dbSNP
rs1490547746 247 dbSNP
rs1413570404 254 dbSNP
rs1425592548 257 dbSNP
rs539827939 258 dbSNP
rs1471442832 261 dbSNP
rs1192774369 272 dbSNP
rs113965034 279 dbSNP
rs1046109063 280 dbSNP
rs1418223665 286 dbSNP
rs1156512547 287 dbSNP
rs1004352522 295 dbSNP
rs1255191443 304 dbSNP
rs369993551 311 dbSNP
rs886891257 312 dbSNP
rs1243931480 314 dbSNP
rs58731484 315 dbSNP
rs557738128 324 dbSNP
rs11434963 326 dbSNP
rs200764069 326 dbSNP
rs66524908 326 dbSNP
rs1265371105 328 dbSNP
rs972721830 341 dbSNP
rs1311896236 343 dbSNP
rs962279145 344 dbSNP
rs774493239 348 dbSNP
rs920807386 354 dbSNP
rs181288938 356 dbSNP
rs538470908 357 dbSNP
rs1458108501 371 dbSNP
rs1278084739 384 dbSNP
rs577740145 387 dbSNP
rs912081704 406 dbSNP
rs1300628906 407 dbSNP
rs1446832930 409 dbSNP
rs60427160 414 dbSNP
rs35721573 415 dbSNP
rs59712849 415 dbSNP
rs386736348 416 dbSNP
rs1444430266 417 dbSNP
rs34120804 417 dbSNP
rs567014482 425 dbSNP
rs1244407991 426 dbSNP
rs1263895274 431 dbSNP
rs1046191508 438 dbSNP
rs181789097 444 dbSNP
rs1257466137 445 dbSNP
rs1456830239 460 dbSNP
rs892353770 470 dbSNP
rs567632030 484 dbSNP
rs958066136 486 dbSNP
rs1244195033 498 dbSNP
rs549391113 500 dbSNP
rs1423594512 502 dbSNP
rs1186452433 506 dbSNP
rs1033529310 509 dbSNP
rs1366326623 510 dbSNP
rs1171227851 519 dbSNP
rs1170807817 524 dbSNP
rs936322881 526 dbSNP
rs138276509 530 dbSNP
rs1338605338 531 dbSNP
rs1050124036 539 dbSNP
rs933527180 547 dbSNP
rs1310256275 555 dbSNP
rs970643604 559 dbSNP
rs1219411838 564 dbSNP
rs1024751465 568 dbSNP
rs972223143 570 dbSNP
rs1421730254 571 dbSNP
rs1483157269 574 dbSNP
rs940960527 576 dbSNP
rs1004085794 580 dbSNP
rs754507989 589 dbSNP
rs765954813 592 dbSNP
rs755283769 594 dbSNP
rs1238221735 595 dbSNP
rs984820651 598 dbSNP
rs1205847726 602 dbSNP
rs780306055 611 dbSNP
rs1300873542 612 dbSNP
rs1257839691 614 dbSNP
rs757581652 616 dbSNP
rs1219769673 617 dbSNP
rs567176298 620 dbSNP
rs1400903303 624 dbSNP
rs552056478 632 dbSNP
rs1309923529 633 dbSNP
rs981526877 634 dbSNP
rs971472575 635 dbSNP
rs868217508 644 dbSNP
rs1262879551 645 dbSNP
rs1379300112 649 dbSNP
rs1216968041 651 dbSNP
rs1025242438 654 dbSNP
rs764652817 671 dbSNP
rs533575103 674 dbSNP
rs1267361891 685 dbSNP
rs912175043 686 dbSNP
rs1432540053 698 dbSNP
rs1173858308 713 dbSNP
rs145706993 716 dbSNP
rs1032206621 720 dbSNP
rs1158324459 727 dbSNP
rs1358891583 738 dbSNP
rs1406949239 741 dbSNP
rs1052356432 748 dbSNP
rs536630418 749 dbSNP
rs551195667 759 dbSNP
rs1366693147 760 dbSNP
rs529013907 769 dbSNP
rs140479216 782 dbSNP
rs1351062423 784 dbSNP
rs1223241531 786 dbSNP
rs958256084 788 dbSNP
rs540244244 792 dbSNP
rs189429929 793 dbSNP
rs1414639332 815 dbSNP
rs1440183934 825 dbSNP
rs1050007859 827 dbSNP
rs1378178396 851 dbSNP
rs564412422 852 dbSNP
rs759600431 855 dbSNP
rs933077263 859 dbSNP
rs183577010 860 dbSNP
rs1004416138 869 dbSNP
rs1300467812 875 dbSNP
rs551225377 881 dbSNP
rs575180081 882 dbSNP
rs1199708406 893 dbSNP
rs1481895323 894 dbSNP
rs1378318304 901 dbSNP
rs1446614585 903 dbSNP
rs1307554095 912 dbSNP
rs951255976 914 dbSNP
rs940858703 920 dbSNP
rs556765904 927 dbSNP
rs1320644316 932 dbSNP
rs1027123313 937 dbSNP
rs995284356 938 dbSNP
rs899605150 939 dbSNP
rs771083567 949 dbSNP
rs1236198492 950 dbSNP
rs1007930752 960 dbSNP
rs192795133 966 dbSNP
rs766855336 968 dbSNP
rs574093295 969 dbSNP
rs1172660583 973 dbSNP
rs892654756 975 dbSNP
rs1401053893 978 dbSNP
rs1309682744 987 dbSNP
rs1392864226 990 dbSNP
rs1020348434 995 dbSNP
rs1408816882 998 dbSNP
rs988408341 1003 dbSNP
rs1302587459 1004 dbSNP
rs1054387367 1006 dbSNP
rs1378033830 1011 dbSNP
rs936745198 1012 dbSNP
rs1226190625 1020 dbSNP
rs878928134 1027 dbSNP
rs1388350863 1029 dbSNP
rs1279554167 1037 dbSNP
rs555552098 1067 dbSNP
rs926743748 1068 dbSNP
rs1458362962 1071 dbSNP
rs1366265831 1073 dbSNP
rs1032258591 1079 dbSNP
rs1420621971 1085 dbSNP
rs1165622788 1088 dbSNP
rs980739084 1089 dbSNP
rs1482408288 1102 dbSNP
rs1196103451 1103 dbSNP
rs1424509464 1105 dbSNP
rs949392418 1107 dbSNP
rs1379972530 1113 dbSNP
rs1415510094 1118 dbSNP
rs917800306 1134 dbSNP
rs189548592 1136 dbSNP
rs3793662 1139 dbSNP
rs997175199 1140 dbSNP
rs558174464 1141 dbSNP
rs974340193 1149 dbSNP
rs540184878 1166 dbSNP
rs1347075353 1168 dbSNP
rs1219665773 1171 dbSNP
rs1277729246 1172 dbSNP
rs571770552 1177 dbSNP
rs1018075873 1182 dbSNP
rs1007858628 1183 dbSNP
rs146794711 1187 dbSNP
rs1049225654 1202 dbSNP
rs1030971068 1203 dbSNP
rs1009804455 1204 dbSNP
rs1248465355 1207 dbSNP
rs1478649536 1217 dbSNP
rs1213883492 1224 dbSNP
rs1050852752 1225 dbSNP
rs937590982 1234 dbSNP
rs892740366 1236 dbSNP
rs1240754303 1240 dbSNP
rs1329083829 1244 dbSNP
rs1053951582 1251 dbSNP
rs748068428 1253 dbSNP
rs551232561 1255 dbSNP
rs1332309118 1263 dbSNP
rs913340900 1268 dbSNP
rs1274148411 1278 dbSNP
rs1365288514 1288 dbSNP
rs1242084354 1290 dbSNP
rs1045136788 1291 dbSNP
rs1305011544 1295 dbSNP
rs1353270782 1295 dbSNP
rs1214656432 1305 dbSNP
rs957643981 1309 dbSNP
rs746203236 1313 dbSNP
rs979204793 1321 dbSNP
rs1245458974 1328 dbSNP
rs1442035969 1330 dbSNP
rs529433362 1334 dbSNP
rs143384326 1335 dbSNP
rs1376278295 1338 dbSNP
rs1175840912 1342 dbSNP
rs1392308798 1346 dbSNP
rs184681894 1349 dbSNP
rs1271618167 1358 dbSNP
rs1192162226 1375 dbSNP
rs528177680 1381 dbSNP
rs1448820848 1382 dbSNP
rs1309733753 1383 dbSNP
rs1487638791 1387 dbSNP
rs563782707 1396 dbSNP
rs1206518400 1399 dbSNP
rs545371708 1402 dbSNP
rs530747577 1410 dbSNP
rs1357197122 1413 dbSNP
rs1014965761 1417 dbSNP
rs149230114 1420 dbSNP
rs746511395 1422 dbSNP
rs887497821 1423 dbSNP
rs528642322 1426 dbSNP
rs1438188376 1429 dbSNP
rs963874168 1432 dbSNP
rs906141289 1433 dbSNP
rs910938816 1434 dbSNP
rs986559952 1440 dbSNP
rs955133505 1443 dbSNP
rs1276182853 1451 dbSNP
rs1045973046 1457 dbSNP
rs36034699 1465 dbSNP
rs913233102 1466 dbSNP
rs574502371 1467 dbSNP
rs956974591 1474 dbSNP
rs555839778 1475 dbSNP
rs936111828 1481 dbSNP
rs1282513389 1486 dbSNP
rs1219828350 1489 dbSNP
rs1033010693 1490 dbSNP
rs540412803 1494 dbSNP
rs10992645 1502 dbSNP
rs1456787645 1503 dbSNP
rs369597684 1503 dbSNP
rs905384538 1504 dbSNP
rs1257225346 1505 dbSNP
rs1442657733 1514 dbSNP
rs558215123 1516 dbSNP
rs979265407 1518 dbSNP
rs1415107113 1519 dbSNP
rs1478497840 1520 dbSNP
rs1045106622 1521 dbSNP
rs1013603939 1528 dbSNP
rs1171353838 1531 dbSNP
rs1422853460 1535 dbSNP
rs896590834 1536 dbSNP
rs953208777 1538 dbSNP
rs539828693 1545 dbSNP
rs1047048840 1553 dbSNP
rs1431907082 1555 dbSNP
rs930003981 1562 dbSNP
rs1169095649 1563 dbSNP
rs778259748 1571 dbSNP
rs867873279 1578 dbSNP
rs1311259821 1584 dbSNP
rs756604163 1599 dbSNP
rs753249447 1605 dbSNP
rs919814881 1606 dbSNP
rs1257015757 1609 dbSNP
rs569589593 1609 dbSNP
rs1254989627 1618 dbSNP
rs1254930696 1619 dbSNP
rs1014605153 1621 dbSNP
rs1261749892 1621 dbSNP
rs557638548 1622 dbSNP
rs1038302024 1625 dbSNP
rs951800200 1635 dbSNP
rs1462440490 1638 dbSNP
rs1255981103 1654 dbSNP
rs767913349 1655 dbSNP
rs942481224 1667 dbSNP
rs911074743 1680 dbSNP
rs1362725937 1689 dbSNP
rs536054302 1690 dbSNP
rs1297678165 1695 dbSNP
rs192727330 1698 dbSNP
rs1229636447 1699 dbSNP
rs1338805406 1706 dbSNP
rs530899995 1708 dbSNP
rs528202106 1717 dbSNP
rs1288546394 1720 dbSNP
rs1284757641 1728 dbSNP
rs139449724 1728 dbSNP
rs370310832 1728 dbSNP
rs923957641 1728 dbSNP
rs563457986 1735 dbSNP
rs935983168 1736 dbSNP
rs1032530228 1738 dbSNP
rs1329820240 1742 dbSNP
rs904651379 1743 dbSNP
rs1001091945 1756 dbSNP
rs1440614610 1768 dbSNP
rs551770032 1770 dbSNP
rs1397894982 1776 dbSNP
rs1343555189 1780 dbSNP
rs1459486205 1795 dbSNP
rs530395677 1799 dbSNP
rs932701268 1804 dbSNP
rs921796808 1805 dbSNP
rs1023743757 1806 dbSNP
rs776349884 1807 dbSNP
rs1378093224 1808 dbSNP
rs1013739667 1818 dbSNP
rs1305811948 1820 dbSNP
rs563245301 1821 dbSNP
rs1471502128 1823 dbSNP
rs545242177 1824 dbSNP
rs896563989 1825 dbSNP
rs1467989192 1828 dbSNP
rs1047591174 1829 dbSNP
rs529438277 1831 dbSNP
rs373135463 1834 dbSNP
rs1239855144 1845 dbSNP
rs1458023829 1847 dbSNP
rs3829123 1849 dbSNP
rs1406087785 1856 dbSNP
rs1165573624 1865 dbSNP
rs1367907382 1870 dbSNP
rs372339851 1871 dbSNP
rs769577124 1872 dbSNP
rs188517510 1878 dbSNP
rs1446538137 1879 dbSNP
rs911177818 1888 dbSNP
rs1370731797 1899 dbSNP
rs1229620473 1906 dbSNP
rs1314530848 1913 dbSNP
rs951684770 1915 dbSNP
rs1050914299 1919 dbSNP
rs1333523994 1928 dbSNP
rs1027444180 1940 dbSNP
rs1259892927 1959 dbSNP
rs1318445973 1965 dbSNP
rs1203595958 1969 dbSNP
rs564539383 1977 dbSNP
rs776496694 1981 dbSNP
rs183140955 1982 dbSNP
rs933822285 1994 dbSNP
rs979851427 2000 dbSNP
rs1182651441 2004 dbSNP
rs912948706 2005 dbSNP
rs1446449510 2006 dbSNP
rs147789120 2007 dbSNP
rs1425013852 2014 dbSNP
rs768496258 2014 dbSNP
rs1336759395 2015 dbSNP
rs1331387379 2029 dbSNP
rs557312864 2039 dbSNP
rs535816309 2043 dbSNP
rs80280404 2044 dbSNP
rs892069941 2045 dbSNP
rs553175774 2055 dbSNP
rs1032333963 2057 dbSNP
rs1279490851 2059 dbSNP
rs1318517944 2060 dbSNP
rs1163708180 2070 dbSNP
rs1000195074 2075 dbSNP
rs553324204 2076 dbSNP
rs1313734928 2083 dbSNP
rs969603005 2084 dbSNP
rs1177658990 2088 dbSNP
rs368783866 2089 dbSNP
rs992298303 2096 dbSNP
rs1049685119 2101 dbSNP
rs2185974 2114 dbSNP
rs772021890 2119 dbSNP
rs1185285997 2123 dbSNP
rs1427748788 2129 dbSNP
rs1415385516 2131 dbSNP
rs1025699081 2132 dbSNP
rs771658424 2142 dbSNP
rs1432404281 2147 dbSNP
rs1299510501 2148 dbSNP
rs1234406620 2150 dbSNP
rs1040231155 2156 dbSNP
rs994676735 2157 dbSNP
rs1340577993 2158 dbSNP
rs898602213 2159 dbSNP
rs1016938770 2164 dbSNP
rs1268311665 2171 dbSNP
rs1369524685 2178 dbSNP
rs745501094 2183 dbSNP
rs889668281 2184 dbSNP
rs570232970 2187 dbSNP
rs1451034729 2188 dbSNP
rs1219059463 2191 dbSNP
rs933812935 2194 dbSNP
rs891644149 2199 dbSNP
rs1214342685 2204 dbSNP
rs1052983529 2219 dbSNP
rs1353649004 2223 dbSNP
rs1478622460 2228 dbSNP
rs1223383660 2233 dbSNP
rs192479604 2234 dbSNP
rs374885830 2240 dbSNP
rs1452247263 2246 dbSNP
rs979734817 2254 dbSNP
rs948390502 2259 dbSNP
rs12003067 2265 dbSNP
rs1385098701 2269 dbSNP
rs1399592620 2272 dbSNP
rs1315547465 2274 dbSNP
rs1223436347 2277 dbSNP
rs1351552342 2277 dbSNP
rs536658699 2278 dbSNP
rs1437036043 2289 dbSNP
rs748316881 2291 dbSNP
rs188062915 2304 dbSNP
rs1024455308 2307 dbSNP
rs992832874 2317 dbSNP
rs1350169671 2319 dbSNP
rs144330072 2321 dbSNP
rs956402756 2323 dbSNP
rs1452702861 2330 dbSNP
rs1026213853 2344 dbSNP
rs1213599622 2348 dbSNP
rs1331080921 2351 dbSNP
rs1031802174 2352 dbSNP
rs1459344850 2353 dbSNP
rs1180175828 2356 dbSNP
rs1000415519 2360 dbSNP
rs529974958 2362 dbSNP
rs962786664 2363 dbSNP
rs1415316066 2364 dbSNP
rs756479083 2365 dbSNP
rs182287172 2378 dbSNP
rs1392087356 2381 dbSNP
rs1028299003 2387 dbSNP
rs547292471 2388 dbSNP
rs753136711 2392 dbSNP
rs996786081 2397 dbSNP
rs1006861300 2398 dbSNP
rs1409885616 2399 dbSNP
rs901287895 2400 dbSNP
rs1170638078 2404 dbSNP
rs1477645010 2407 dbSNP
rs1041517388 2408 dbSNP
rs1201547233 2409 dbSNP
rs1490842638 2410 dbSNP
rs1261145654 2411 dbSNP
rs58328126 2413 dbSNP
rs1317783174 2418 dbSNP
rs1008770232 2419 dbSNP
rs1217779501 2421 dbSNP
rs1271797657 2426 dbSNP
rs886273363 2427 dbSNP
rs1323313257 2428 dbSNP
rs1284411424 2429 dbSNP
rs1225898915 2431 dbSNP
rs1199694891 2432 dbSNP
rs1337754833 2433 dbSNP
rs143635008 2434 dbSNP
rs3833715 2434 dbSNP
rs60697044 2434 dbSNP
rs1287852164 2439 dbSNP
rs2185973 2443 dbSNP
rs1346648075 2444 dbSNP
rs1179221216 2454 dbSNP
rs1238743589 2456 dbSNP
rs564578402 2457 dbSNP
rs1029560038 2458 dbSNP
rs1413664756 2463 dbSNP
rs1467062482 2464 dbSNP
rs1429746502 2468 dbSNP
rs113080913 2473 dbSNP
rs998494486 2486 dbSNP
rs3996276 2487 dbSNP
rs190848858 2488 dbSNP
rs112391926 2489 dbSNP
rs1251172182 2495 dbSNP
rs1193767943 2504 dbSNP
rs4410965 2515 dbSNP
rs2398823 2518 dbSNP
rs1186615003 2525 dbSNP
rs1047561277 2530 dbSNP
rs536667127 2534 dbSNP
rs935887618 2538 dbSNP
rs1478793053 2542 dbSNP
rs1208287232 2545 dbSNP
rs904239961 2545 dbSNP
rs1372326784 2552 dbSNP
rs1460256305 2553 dbSNP
rs776716279 2555 dbSNP
rs867052729 2564 dbSNP
rs930557743 2566 dbSNP
rs1434266777 2571 dbSNP
rs1044130456 2581 dbSNP
rs575803223 2584 dbSNP
rs1461103973 2585 dbSNP
rs916932860 2594 dbSNP
rs1206115956 2595 dbSNP
rs1056822116 2599 dbSNP
rs939585410 2601 dbSNP
rs918886721 2603 dbSNP
rs948376403 2607 dbSNP
rs1316641593 2611 dbSNP
rs1488965212 2613 dbSNP
rs1294209508 2615 dbSNP
rs973273775 2623 dbSNP
rs112490039 2624 dbSNP
rs1260981781 2625 dbSNP
rs1363494020 2626 dbSNP
rs909940696 2635 dbSNP
rs1395394207 2636 dbSNP
rs1454050416 2637 dbSNP
rs917045896 2650 dbSNP
rs1382300194 2655 dbSNP
rs1454395030 2664 dbSNP
rs1282001845 2665 dbSNP
rs1383446687 2665 dbSNP
rs1388976281 2666 dbSNP
rs1327068893 2671 dbSNP
rs985563569 2673 dbSNP
rs1370706220 2674 dbSNP
rs3750556 2676 dbSNP
rs1451481320 2680 dbSNP
rs1300773686 2681 dbSNP
rs954136168 2682 dbSNP
rs3750555 2689 dbSNP
rs1484860438 2691 dbSNP
rs998233582 2694 dbSNP
rs1338500687 2696 dbSNP
rs1211561777 2703 dbSNP
rs1463977618 2713 dbSNP
rs542190775 2714 dbSNP
rs10992644 2722 dbSNP
rs1031589501 2724 dbSNP
rs575047047 2725 dbSNP
rs999949642 2727 dbSNP
rs924797783 2728 dbSNP
rs752158669 2736 dbSNP
rs766359967 2737 dbSNP
rs1362126160 2739 dbSNP
rs1421756720 2744 dbSNP
rs28399238 2747 dbSNP
rs1166241243 2748 dbSNP
rs534890359 2751 dbSNP
rs1439184221 2765 dbSNP
rs1333737946 2766 dbSNP
rs28722632 2769 dbSNP
rs558717821 2772 dbSNP
rs1305744861 2775 dbSNP
rs1206024004 2784 dbSNP
rs1456733895 2787 dbSNP
rs1235113493 2799 dbSNP
rs1273763403 2803 dbSNP
rs1334022269 2807 dbSNP
rs185996722 2810 dbSNP
rs1004712683 2812 dbSNP
rs115068718 2814 dbSNP
rs183137661 2815 dbSNP
rs1244788172 2817 dbSNP
rs928991250 2818 dbSNP
rs536212873 2823 dbSNP
rs1383131477 2826 dbSNP
rs918800898 2827 dbSNP
rs1417810426 2828 dbSNP
rs1460273753 2836 dbSNP
rs1037299725 2837 dbSNP
rs1444253238 2838 dbSNP
rs941487882 2843 dbSNP
rs910034985 2850 dbSNP
rs1370664743 2851 dbSNP
rs985656834 2852 dbSNP
rs916911289 2857 dbSNP
rs1056773429 2860 dbSNP
rs1463514820 2862 dbSNP
rs934423678 2866 dbSNP
rs1127832 2875 dbSNP
rs1307824782 2882 dbSNP
rs1161794594 2885 dbSNP
rs1204146285 2889 dbSNP
rs116415036 2893 dbSNP
rs1188749178 2896 dbSNP
rs765462506 2907 dbSNP
rs1386042486 2914 dbSNP
rs978929911 2915 dbSNP
rs1185690663 2917 dbSNP
rs1438148918 2923 dbSNP
rs968851808 2929 dbSNP
rs922747940 2937 dbSNP
rs1436130939 2938 dbSNP
rs1250279184 2939 dbSNP
rs977117496 2957 dbSNP
rs956071326 2966 dbSNP
rs965623229 2976 dbSNP
rs1804738 2977 dbSNP
rs1031976425 2979 dbSNP
rs571844064 2982 dbSNP
rs1213809941 2984 dbSNP
rs1293095800 2985 dbSNP
rs1020046018 2987 dbSNP
rs1000086894 2990 dbSNP
rs982777841 2992 dbSNP
rs1279787961 3005 dbSNP
rs1484719200 3006 dbSNP
rs867369018 3010 dbSNP
rs532436505 3012 dbSNP
rs1243228762 3014 dbSNP
rs1485788341 3018 dbSNP
rs951463803 3032 dbSNP
rs968629183 3046 dbSNP
rs1022740476 3053 dbSNP
rs1012736732 3055 dbSNP
rs1459876080 3065 dbSNP
rs1394008673 3067 dbSNP
rs1027056733 3083 dbSNP
rs1345722722 3085 dbSNP
rs1429872148 3092 dbSNP
rs994704988 3099 dbSNP
rs547242782 3104 dbSNP
rs1235352698 3105 dbSNP
rs141785346 3108 dbSNP
rs776319457 3109 dbSNP
rs763985939 3117 dbSNP
rs897509573 3118 dbSNP
rs760504059 3122 dbSNP
rs1037397350 3131 dbSNP
rs146276418 3137 dbSNP
rs879554589 3138 dbSNP
rs1469166934 3139 dbSNP
rs934331562 3140 dbSNP
rs1366280330 3141 dbSNP
rs888736759 3146 dbSNP
rs1049920339 3156 dbSNP
rs1159812916 3159 dbSNP
rs1408057691 3166 dbSNP
rs932806989 3171 dbSNP
rs1156820556 3176 dbSNP
rs1396535520 3178 dbSNP
rs947097335 3179 dbSNP
rs1324893464 3185 dbSNP
rs922641053 3198 dbSNP
rs1444616286 3204 dbSNP
rs1160343599 3209 dbSNP
rs976875114 3210 dbSNP
rs528681486 3214 dbSNP
rs924616381 3215 dbSNP
rs1336062070 3217 dbSNP
rs1127851 3232 dbSNP
rs1271598966 3250 dbSNP
rs1127852 3259 dbSNP
rs1449574400 3262 dbSNP
rs944305479 3264 dbSNP
rs1232994958 3270 dbSNP
rs968598002 3271 dbSNP
rs1179337739 3277 dbSNP
rs1022840303 3281 dbSNP
rs531058733 3283 dbSNP
rs563767472 3286 dbSNP
rs951351566 3287 dbSNP
rs1388302424 3292 dbSNP
rs1485362222 3303 dbSNP
rs771478159 3321 dbSNP
rs1329760983 3322 dbSNP
rs1127857 3325 dbSNP
rs1240860635 3327 dbSNP
rs1310253856 3330 dbSNP
rs974164314 3335 dbSNP
rs12238760 3344 dbSNP
rs1224063377 3345 dbSNP
rs1346220167 3348 dbSNP
rs1271740565 3349 dbSNP
rs897599752 3355 dbSNP
rs1023238860 3358 dbSNP
rs1197235813 3370 dbSNP
rs563661494 3373 dbSNP
rs1273298407 3374 dbSNP
rs1436797182 3380 dbSNP
rs1012734403 3384 dbSNP
rs1015931685 3394 dbSNP
rs1475531382 3397 dbSNP
rs1005931244 3398 dbSNP
rs7033638 3405 dbSNP
rs1366546837 3410 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000375446.4 | 3UTR | AUUUGAUGGAAAAGAGUAAAAGAUGAAAAGAUUGACUGAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000375446.4 | 3UTR | AAAAGAUGAAAAGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.705 3.6e-3 -0.703 3.7e-3 13 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.346 6.8e-2 -0.176 2.3e-1 20 Click to see details
GSE14794 Lymphoblastoid cells -0.142 9.1e-2 -0.114 1.4e-1 90 Click to see details
GSE26953 Aortic valvular endothelial cells -0.265 1.1e-1 -0.261 1.1e-1 24 Click to see details
GSE27834 Pluripotent stem cells 0.303 1.3e-1 -0.024 4.6e-1 16 Click to see details
GSE28544 Breast cancer 0.235 1.3e-1 0.350 4.7e-2 24 Click to see details
GSE21687 Ependynoma primary tumors -0.12 1.7e-1 -0.111 1.9e-1 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.181 2.0e-1 -0.197 1.8e-1 23 Click to see details
GSE17306 Multiple myeloma 0.12 2.1e-1 0.503 1.2e-4 49 Click to see details
GSE19350 CNS germ cell tumors 0.194 2.7e-1 0.531 3.8e-2 12 Click to see details
GSE17498 Multiple myeloma 0.087 3.0e-1 0.048 3.8e-1 40 Click to see details
GSE21849 B cell lymphoma -0.081 3.4e-1 -0.071 3.6e-1 29 Click to see details
GSE38226 Liver fibrosis 0.089 3.5e-1 -0.103 3.3e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.045 4.0e-1 0.132 2.4e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.031 4.4e-1 0.029 4.5e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.031 4.4e-1 0.029 4.5e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.031 4.4e-1 0.029 4.5e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.357 0.01 -0.364 0.01 42 Click to see details
LIHC 0.236 0.05 0.192 0.09 49 Click to see details
LUAD -0.499 0.06 -0.627 0.02 11 Click to see details
CHOL -0.508 0.08 -0.417 0.13 9 Click to see details
BLCA 0.35 0.08 0.282 0.14 17 Click to see details
KICH -0.288 0.09 -0.338 0.05 24 Click to see details
STAD -0.235 0.11 -0.096 0.31 29 Click to see details
PRAD 0.171 0.12 0.208 0.08 48 Click to see details
LUSC -0.185 0.13 -0.152 0.18 38 Click to see details
UCEC -0.186 0.22 -0.258 0.14 19 Click to see details
BRCA -0.086 0.23 -0.165 0.07 79 Click to see details
CESC 0.721 0.24 0.500 0.33 3 Click to see details
KIRC -0.078 0.27 -0.139 0.13 65 Click to see details
KIRP -0.115 0.27 0.066 0.36 31 Click to see details
THCA 0.052 0.35 0.084 0.26 59 Click to see details
PAAD 0.177 0.41 0.600 0.2 4 Click to see details
ESCA -0.003 0.5 0.217 0.29 9 Click to see details
ESCA -0.003 0.5 0.217 0.29 9 Click to see details
ESCA -0.003 0.5 0.217 0.29 9 Click to see details
ESCA -0.003 0.5 0.217 0.29 9 Click to see details
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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