pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZCCHC24   
Synonyms C10orf56, Z3CXXC8
Description zinc finger CCHC-type containing 24
Transcript NM_153367   
Expression
Putative miRNA Targets on ZCCHC24
3'UTR of ZCCHC24
(miRNA target sites are highlighted)
>ZCCHC24|NM_153367|3'UTR
   1 CGGGCTGCCCGCCCGCACCCAGAGCCACCCCCCGCCAGCCCGAGGAGACGCTGCTTCCCTGTGCTACTCCGAGGGGCTGC
  81 GTGTCGCCCTGTGCATGGGGTGCCCTCGCAGGCCTGCGGGGCTGGGCCGGGGGCTCTTAGCGTCCTTGTCTTGTGTGTGT
 161 TGACAAACAGTGTTACTGACATTGCTGCCCCCCACAGGCCAGGGAAAGCAGGGAGTCTGGGGCTTTTTGCAGGCGGGCCT
 241 GGGGTCTCAGTGGAGGGGACAAAGGCAAGCAAAAGCCCATGTCCAGGAGCCCTGGGTGTCCCCACAGGCTCGCCTCTGAG
 321 AGCCTCTTTGGGGTGAGCAGCCTTGTATTGGCCACAGGTGCACTAAATTGACTGTGAATCCCAAACCTCCCCAGACCAGC
 401 CAGGCCGCCTGCCCCCACCCAGAACCTTCCGGTTTGCCCTGTATGGAAAGCCACTCTCAGAAATCCCTCTTTCCTGAGTC
 481 AGCAATCGTGGCAAGGGGACATGTGTTCCAACAGCGGCTGGGGAGTGGACCTCTCTGTCCCTTGCCCACCTTAAGCCCCA
 561 AATCCAGACCCCCTCTGACATCACTGGCATTGCACCTGGGTGTGCCCCCCTCCCCACGCTATGGACCCAGATAGGAGGGG
 641 TTAGGCATGGGGGAGGCACAGAATGCTGGAGAGATGCGTCCTGGTGAACGTGGGGCAGCCCCTCCCACGACCCCCACCAG
 721 ACTGCCTTAGGTTTTGTCAGCCCCACTCCCTTTCCTTCCCCTCTGCCTCCCACCCACTCTGGGGGTCCACATCAAGATAG
 801 CTGGGCCCAGTGTGGAAGCCCAGCGTGTCTGTTCCAGCAGAAAGGACACAAGCCTGGTGTTCTGGAGACCTCGGCTCAAG
 881 TCTTTGCCCTGCTGCCGACGCATTGTGTCACCTTGGGCAAGGACTTCGCATCTCCAGGCCTCAGTTTCCCCATTAGTTAA
 961 ATGACAGCATAACACTAGAGAGCAGAGGGCCCATTTCAGCTCTGTTGTTCTGGGATTCAGGCTGGCCGGTGCTGTGTCCT
1041 GGAGCTTTATTTGGGGAGTTTCACCCAGAATGGTGGGAGAAACCTCCCAGGTGCCAGGTACCCCGCATCGTGACCCTTCA
1121 CTTGGTGTCTTAGGAAGTCAAGCTGAGGGATGCTGAGTCCTCCCCTGCTGGCCCCTGCAGCCCCAGCCCTGCTTTTCATC
1201 CCCCACCCCTGCAAACATGGAGGAGCCCCCTCCTTCTCACCTCGGTCTCCTAGCCCCTGACATGGAGAACCCTGAGACAA
1281 GCCACAGAACCCCTCTTTTCTAAAATGGAGACAATAATTTCCTACCTCCCAAGGGAGCAGAGAGGCCTCGTGGCACGTCC
1361 GTGGCCAGGGAGCCCACTGTCCTGGCTGGCGGCGGGATCGTGCGCTCCTCTGTCTCCCGGATGAGAAGCCCCGTTTCCAT
1441 GGTCTTGACCCTTCCTTTCTCCCGGCTGTCAGAACTGGGTCTCTTGATTTTGCCCCTACATTATGCCTCTGTGGGAAAAA
1521 AAAAAAATCAGACCAAGAAATGAGCCTGAAATTCAGTGTTTACCATGGCTCAAGGATGCCCATCTGGTGTCCAGTTGCCT
1601 TTTGTATTCAAATGAAAATGCTTTGTACAACTGAGGAGTTACAGTGAAGTGTTAACCAGGGGTCCAGGGAGCGAGTTGAA
1681 AAGATGGAGTGAGTGTATTTGCAGCCAGGGAGCTGCAGGGTGGATTTGAGGGGCCATACCCTCTGAGCACTTAAAAAAGG
1761 TATTTGCTCCAGGCCAGGCAGCAGGCTGTGGACACCCTTGCCACCACTGGGGACTGCCACTGAGGACTCCCCGAGCACGT
1841 TGTTCCCCGTCTTCTCCAAGGTGTTGAGGTGAGCTGGGGTTGGCCCCGGCCCAGGCTTCTGTCCCAAGGAGAAGCTGCCA
1921 CTGACAGTCATCCTACCGCACTGCTAAAGAGAATGTTCGCAGTGGTGGGCGGCGTGCCTGTGCCAACCCTTCCAGGGACC
2001 CGGCCATGGGGGACCTTGGCCCAAGGATGCCTGGGGCCTGCCAGCTGTGCTGCAAAGGTGGGGGGCCCACACCCTAAAAC
2081 TAACCCAGGCCCCAGACCACTGGAGGCCAGGGCTTCCCTGCACGGGCTAAGGGGAGTTGGGATATCACCCCAAAGTGACC
2161 TTGCCAGTGAGCTGTTCAGCAGGTAGCCACTGCCCTGCCATCTGTGCAGAGCCAGCCACCTTGGGGGCTGGGGTTCCCGC
2241 TTTGAGGCCCACCTTCCATACTCCCCTTGACTCGGCTCTGGCTGAACTGGGGAACTCTCTTGTGGTCAGCAAAGCCCCTG
2321 CCATGCAGGCCAGGTGCCATTGAGAATTAAGTGCTCAGAGGGCCAGGAGCCCAGGGGATGGGAAAGTGTGTGGTTTTAGT
2401 ACGTTCAAAAGGGACAATCGCTTGCAGTTGGTAGATCTAGCGATCTAGTTGGGAGATAATGGTGTTTACCCCATATGAAG
2481 TATTCAATAGTTCTACTTGTGAATTTGTATTTATTTTGAGTTATACTTGACACAGAATTCCTTTTTTAAAAAAATATGTG
2561 TGTATTTTGGAAAAAAAATTCATAGATGTTAAAATTTCTGCATGGTTACCAGTTTTTCTCACAACACTGAATTTGGTAGC
2641 TTTTCCCGAAAAAATCTTCACAGTAATTTTTTGTCTGTATATATTTGAGGGCCTTTTTTTAAAAAAAAAAAAAGAAAAGA
2721 AAAATATAATTGTTTGATTTTTGAGATTAAAACAAACAAAAAGAGAGGCATTTTCAAAATTTCAGAACTTTCAGGAGGGC
2801 AAGAGAATATCAAACAAAGATTTCTGGAAGTATTTTGCCAACCTTCTGGTTGAGCTGCAAGAAAATATTTATGGTGAGAA
2881 CTTTTCTGTTTCCCGTTATTGGGTTTTTGGTTGGTTTTTGTTTGTTTTTTACTATGCTTTGGTCTGTAAAAATATGCAAC
2961 TGAACTACATTCAGAAGGAAATATTGTCTACATAGAATATTATATGAAGTTGGTACATAATTCTGATGAGGAAAAAAAAT
3041 CTTTGCAATTCTTTAAGCCATATTGTTGTTTTTCTGTGTTGTTTTCCCTGGATGAAAATATCAGTATTAAGTAGACAGCA
3121 TATTATTCAAGTGTTTAGACTTATTAATATGTTCTTGTCCTGTATTTATACATATGTGTATTTTGGAAAGTATTGCCTTT
3201 TTTAAGGGAAGCTATAATTCGATACATAGTGAAAAAGGGAATGGTGACCCCTTTGTGCCTCTTCCACTGAGGATAACAAA
3281 CAGCATTGTAATCCATTCTCTTGCACCTTCTTCTTCTTATCTTGTTATTACGGTTTTATTAATTTTGTAGAGGGACAGGG
3361 AGTGGGCAAGGGGAAGAAGCAGCTTATTTGACTAACCAGCCCCTCTGTGGTCCACCAGCGTCTTGGCTTGGTGGGAGGGC
3441 TCTCAATCAGCAGGGCCCCAGGAGGGAAGAAGAAGTGGGGCAAAGCCTGGCCTCGCCGCTCGGGAGCTTTGCCATCTGAG
3521 CCACGCCTCCTCCAGGCCATGCTCCTTGAACTTGGAAATGTCAACCGGAGCCCTTACACCAGCCCTCCAGCATCTAATAG
3601 ACTTGAATCTACTCTAAACGAATATTTAATCCAACCTCACTACATTGTAGCTCAGTCCAACGACTAACCCTGAAATGGGG
3681 GTGTTCCAGCCTTCAGCGAGATGGCCAAGCGGTCCCCTGGGGGCTGTGGCAGCGGGCTTATCCTTCTCTGTTGCCAACCT
3761 TGCCGTCCGACCTCCTCCGCCCCCATGCGGTGACCCCGTCCGTGTCTGTGTCTGTCCATACGTGTGAGTCCAGCTAAAAA
3841 GACAAAACAGAACCCGTGGGCCCAGCTCGGAAGGTGCGTGGAGAAGGCTCCGACGTCTCCGAAGTGCAGCCCTTGGGATG
3921 GCATTCCGTTGTGTGCCTTATTCCTGGAGAATCTGTATACGGCTCGCCTATAGAAATATAGCCTCTTCATGCTGTATTAA
4001 AAGGACTTTTAAAAGCAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cgguUCCCUUA-CCG-UCCCUUUa 5'
              |||||:| ||| ||||:|| 
Target 5' ggacAGGGAGTGGGCAAGGGGAAg 3'
3353 - 3376 154.00 -23.60
2
miRNA  3' cgguucccuUACCGUCCCUUUa 5'
                   | | |||||||| 
Target 5' gccccccacAGGCCAGGGAAAg 3'
187 - 208 149.00 -14.00
3
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            | ||||:||    |||||| 
Target 5' gcCCAGGGGAT----GGGAAAg 3'
2369 - 2386 133.00 -19.32
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM8330231 1 COSMIC
COSM1966438 28 COSMIC
COSM7581095 34 COSMIC
COSM5759384 38 COSMIC
COSM6501368 42 COSMIC
COSM4447578 57 COSMIC
COSM5419465 64 COSMIC
COSM1966436 70 COSMIC
COSM1966435 85 COSMIC
COSN30137982 169 COSMIC
COSN28238085 172 COSMIC
COSN30511160 235 COSMIC
COSN22368182 244 COSMIC
COSN28738226 400 COSMIC
COSN26150017 432 COSMIC
COSN31542798 487 COSMIC
COSN31572411 492 COSMIC
COSN28751266 566 COSMIC
COSN8721895 1367 COSMIC
COSN21626435 1477 COSMIC
COSN20107303 1515 COSMIC
COSN26648172 1568 COSMIC
COSN29212475 1724 COSMIC
COSN8721894 2001 COSMIC
COSN25047971 2010 COSMIC
COSN8721893 2172 COSMIC
COSN31524335 2425 COSMIC
COSN31577329 2541 COSMIC
COSN21540690 2570 COSMIC
COSN31579833 2570 COSMIC
COSN31519431 2656 COSMIC
COSN17717193 2657 COSMIC
COSN31566802 2699 COSMIC
COSN20107301 2700 COSMIC
COSN31571271 2700 COSMIC
COSN31522304 2701 COSMIC
COSN31593084 2721 COSMIC
COSN22391968 2830 COSMIC
COSN31565133 2883 COSMIC
COSN28811129 2915 COSMIC
COSN17888672 2921 COSMIC
COSN17888675 2925 COSMIC
COSN31568856 2953 COSMIC
COSN31570887 3041 COSMIC
COSN31565135 3220 COSMIC
COSN31571349 3220 COSMIC
COSN20427409 3288 COSMIC
COSN31566806 3335 COSMIC
COSN31524116 3414 COSMIC
COSN28822208 3494 COSMIC
COSN31536989 3516 COSMIC
COSN28703296 3520 COSMIC
COSN31552364 3711 COSMIC
COSN31589269 3733 COSMIC
COSN28832251 3736 COSMIC
COSN28779379 3778 COSMIC
COSN31602596 3788 COSMIC
COSN31596879 3821 COSMIC
COSN31609594 3868 COSMIC
COSN16129511 3869 COSMIC
COSN31539864 3877 COSMIC
COSN31662419 3881 COSMIC
COSN30170894 3901 COSMIC
COSN16129507 3949 COSMIC
COSN31513769 3960 COSMIC
rs6858 3736 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs140265942 1 dbSNP
rs370002671 2 dbSNP
rs752832120 5 dbSNP
rs1460943416 7 dbSNP
rs1241288979 9 dbSNP
rs74319619 10 dbSNP
rs374167546 11 dbSNP
rs1191330639 12 dbSNP
rs369416935 14 dbSNP
rs556425225 15 dbSNP
rs751678276 16 dbSNP
rs1192432371 18 dbSNP
rs1297910603 19 dbSNP
rs1244715645 21 dbSNP
rs766406699 23 dbSNP
rs375394377 25 dbSNP
rs1032318841 26 dbSNP
rs1002289601 27 dbSNP
rs750555292 28 dbSNP
rs1411478769 29 dbSNP
rs760457028 31 dbSNP
rs57224535 33 dbSNP
rs759518581 34 dbSNP
rs759519605 34 dbSNP
rs765306237 34 dbSNP
rs1444163407 36 dbSNP
rs147555076 37 dbSNP
rs199870999 41 dbSNP
rs748973040 42 dbSNP
rs777353308 43 dbSNP
rs769472463 44 dbSNP
rs1484249240 45 dbSNP
rs200553761 49 dbSNP
rs1244877851 50 dbSNP
rs781504524 51 dbSNP
rs755509604 52 dbSNP
rs752012860 57 dbSNP
rs780122414 58 dbSNP
rs758345527 61 dbSNP
rs765439575 65 dbSNP
rs776841213 67 dbSNP
rs372724747 70 dbSNP
rs767368190 71 dbSNP
rs1363920373 72 dbSNP
rs1044092610 75 dbSNP
rs759556563 76 dbSNP
rs1387156591 79 dbSNP
rs7071090 80 dbSNP
rs867814459 81 dbSNP
rs370845465 84 dbSNP
rs770910799 85 dbSNP
rs762426751 86 dbSNP
rs555957290 90 dbSNP
rs1327183464 92 dbSNP
rs1489745527 97 dbSNP
rs1266878848 98 dbSNP
rs769370960 100 dbSNP
rs747797227 102 dbSNP
rs1290706202 104 dbSNP
rs923059430 107 dbSNP
rs1230221599 108 dbSNP
rs559786075 109 dbSNP
rs191374714 117 dbSNP
rs376394076 118 dbSNP
rs780607499 119 dbSNP
rs1295518557 121 dbSNP
rs533492973 122 dbSNP
rs745987773 124 dbSNP
rs1157019506 125 dbSNP
rs1368828759 126 dbSNP
rs1459331631 127 dbSNP
rs570089946 128 dbSNP
rs757455894 129 dbSNP
rs1419107928 136 dbSNP
rs754050780 139 dbSNP
rs1269837577 141 dbSNP
rs767421250 142 dbSNP
rs1032762674 149 dbSNP
rs1002237524 153 dbSNP
rs1359784644 154 dbSNP
rs1373766162 161 dbSNP
rs1258493722 165 dbSNP
rs1414700161 165 dbSNP
rs373388289 168 dbSNP
rs777259551 168 dbSNP
rs766761024 170 dbSNP
rs1405467399 175 dbSNP
rs1262465495 176 dbSNP
rs969373785 180 dbSNP
rs1225723892 181 dbSNP
rs1221550369 185 dbSNP
rs1313745269 189 dbSNP
rs1268004121 193 dbSNP
rs1456305681 194 dbSNP
rs775419124 194 dbSNP
rs1013665404 201 dbSNP
rs1257219924 203 dbSNP
rs1276140246 220 dbSNP
rs1200912673 224 dbSNP
rs1347047852 229 dbSNP
rs1006657901 233 dbSNP
rs547034023 234 dbSNP
rs1036175995 235 dbSNP
rs1443883729 236 dbSNP
rs1026954852 237 dbSNP
rs1231236651 245 dbSNP
rs1450306423 245 dbSNP
rs1006554290 246 dbSNP
rs1393309628 263 dbSNP
rs1434236722 266 dbSNP
rs1370502962 274 dbSNP
rs1310319108 275 dbSNP
rs1405022298 279 dbSNP
rs1380819026 283 dbSNP
rs1318091249 289 dbSNP
rs1003136996 295 dbSNP
rs1449325022 299 dbSNP
rs541301971 308 dbSNP
rs1299418892 310 dbSNP
rs139071236 311 dbSNP
rs931671525 312 dbSNP
rs1256479358 316 dbSNP
rs1331118165 320 dbSNP
rs922926873 322 dbSNP
rs61859930 323 dbSNP
rs1203374806 328 dbSNP
rs1405068881 331 dbSNP
rs1465211942 332 dbSNP
rs1190727104 337 dbSNP
rs1251395800 343 dbSNP
rs1453827452 351 dbSNP
rs892914462 364 dbSNP
rs1379820044 380 dbSNP
rs1054108602 381 dbSNP
rs541611997 385 dbSNP
rs1040112180 386 dbSNP
rs1389804613 388 dbSNP
rs1459201999 389 dbSNP
rs531554800 390 dbSNP
rs1380495922 393 dbSNP
rs562606051 395 dbSNP
rs1046444 400 dbSNP
rs1437457216 405 dbSNP
rs879231497 406 dbSNP
rs554154381 407 dbSNP
rs921095472 412 dbSNP
rs1278935543 413 dbSNP
rs1329538718 414 dbSNP
rs925563083 416 dbSNP
rs981004049 417 dbSNP
rs1468215097 418 dbSNP
rs969408117 429 dbSNP
rs748752205 430 dbSNP
rs1024953857 431 dbSNP
rs1347196135 442 dbSNP
rs1181695115 454 dbSNP
rs1413377340 457 dbSNP
rs534031765 458 dbSNP
rs1046445 459 dbSNP
rs1391761346 460 dbSNP
rs1457088656 483 dbSNP
rs984907842 486 dbSNP
rs1015180083 487 dbSNP
rs1006088828 493 dbSNP
rs887606055 495 dbSNP
rs1332814589 496 dbSNP
rs1351036184 503 dbSNP
rs1229940395 505 dbSNP
rs868482259 513 dbSNP
rs747749904 515 dbSNP
rs752262337 516 dbSNP
rs1360548814 519 dbSNP
rs996020029 520 dbSNP
rs1159943560 522 dbSNP
rs1267510077 523 dbSNP
rs1417402973 528 dbSNP
rs186932633 540 dbSNP
rs1003536764 542 dbSNP
rs74144725 544 dbSNP
rs1186503290 546 dbSNP
rs758641683 547 dbSNP
rs61859929 555 dbSNP
rs1417548004 558 dbSNP
rs201297374 559 dbSNP
rs1063119 566 dbSNP
rs913013414 569 dbSNP
rs150772333 571 dbSNP
rs1054608249 573 dbSNP
rs1186695253 574 dbSNP
rs573866216 575 dbSNP
rs936876309 578 dbSNP
rs1488585327 581 dbSNP
rs1311037350 584 dbSNP
rs925430477 593 dbSNP
rs893323033 605 dbSNP
rs879691305 606 dbSNP
rs1305992147 607 dbSNP
rs1054583895 608 dbSNP
rs1351767122 611 dbSNP
rs934434253 611 dbSNP
rs1283885150 613 dbSNP
rs114799154 617 dbSNP
rs768178531 622 dbSNP
rs141290665 624 dbSNP
rs917926842 626 dbSNP
rs184115394 629 dbSNP
rs1167648083 641 dbSNP
rs1390223861 646 dbSNP
rs1431157890 648 dbSNP
rs921206660 649 dbSNP
rs1358538943 657 dbSNP
rs975346339 657 dbSNP
rs1304389227 673 dbSNP
rs568894256 674 dbSNP
rs962346161 677 dbSNP
rs552241648 678 dbSNP
rs1367379636 679 dbSNP
rs139913461 681 dbSNP
rs951925827 689 dbSNP
rs761892480 690 dbSNP
rs146040104 708 dbSNP
rs1406764224 709 dbSNP
rs1259329406 710 dbSNP
rs527292753 712 dbSNP
rs1187518055 713 dbSNP
rs1248286196 716 dbSNP
rs1450751533 730 dbSNP
rs1191213724 733 dbSNP
rs1028760062 736 dbSNP
rs1411289687 743 dbSNP
rs996052708 744 dbSNP
rs901732082 751 dbSNP
rs532027246 754 dbSNP
rs1009942742 755 dbSNP
rs971601080 759 dbSNP
rs10699717 762 dbSNP
rs1195905386 763 dbSNP
rs891436361 771 dbSNP
rs1054241478 773 dbSNP
rs1221405901 774 dbSNP
rs1023148044 783 dbSNP
rs73293509 785 dbSNP
rs1288081419 787 dbSNP
rs561903050 790 dbSNP
rs78347293 791 dbSNP
rs1245624524 797 dbSNP
rs1478095086 800 dbSNP
rs1192796612 805 dbSNP
rs775548373 806 dbSNP
rs1472102081 807 dbSNP
rs1280697658 811 dbSNP
rs866510206 814 dbSNP
rs1159647704 820 dbSNP
rs771936666 824 dbSNP
rs918207123 825 dbSNP
rs1323186517 830 dbSNP
rs4980069 835 dbSNP
rs1438085925 837 dbSNP
rs902965832 843 dbSNP
rs1296917081 849 dbSNP
rs1350418046 858 dbSNP
rs1347830205 863 dbSNP
rs1229334547 864 dbSNP
rs1290588614 866 dbSNP
rs1324957214 869 dbSNP
rs371012780 873 dbSNP
rs907837031 879 dbSNP
rs1226231634 884 dbSNP
rs1288724580 889 dbSNP
rs193099054 896 dbSNP
rs532409603 897 dbSNP
rs1249455867 899 dbSNP
rs1028791204 900 dbSNP
rs1182890163 903 dbSNP
rs1413862214 905 dbSNP
rs974579171 907 dbSNP
rs965846118 908 dbSNP
rs1039608829 915 dbSNP
rs774362208 916 dbSNP
rs1168451479 917 dbSNP
rs1418816938 919 dbSNP
rs11002952 924 dbSNP
rs909705632 927 dbSNP
rs778072093 928 dbSNP
rs541411919 931 dbSNP
rs929371112 936 dbSNP
rs1213428100 937 dbSNP
rs1229726597 943 dbSNP
rs1340930747 944 dbSNP
rs891475200 946 dbSNP
rs1253906598 947 dbSNP
rs1440413848 948 dbSNP
rs1186615168 962 dbSNP
rs1238217019 968 dbSNP
rs866366498 983 dbSNP
rs1473884299 987 dbSNP
rs1281611851 988 dbSNP
rs1186949004 990 dbSNP
rs1260424825 992 dbSNP
rs1389623825 993 dbSNP
rs1430544051 995 dbSNP
rs1170962408 1001 dbSNP
rs1400736447 1008 dbSNP
rs1414217995 1008 dbSNP
rs981507943 1017 dbSNP
rs971341143 1027 dbSNP
rs572490203 1028 dbSNP
rs1295023180 1030 dbSNP
rs374988667 1034 dbSNP
rs991661024 1042 dbSNP
rs1033069851 1046 dbSNP
rs561976983 1068 dbSNP
rs1199847797 1069 dbSNP
rs1279028323 1071 dbSNP
rs1443990581 1084 dbSNP
rs905576894 1085 dbSNP
rs1044161547 1087 dbSNP
rs1186892535 1091 dbSNP
rs1365026310 1095 dbSNP
rs542290047 1098 dbSNP
rs948241710 1104 dbSNP
rs576504976 1105 dbSNP
rs1173745254 1109 dbSNP
rs76964679 1110 dbSNP
rs940914957 1112 dbSNP
rs1318044089 1126 dbSNP
rs1329061634 1133 dbSNP
rs1387493347 1139 dbSNP
rs1435128780 1148 dbSNP
rs997943731 1153 dbSNP
rs1328887436 1164 dbSNP
rs138823887 1165 dbSNP
rs1275421648 1167 dbSNP
rs1039429006 1172 dbSNP
rs1176859730 1184 dbSNP
rs1346784245 1198 dbSNP
rs1416287917 1200 dbSNP
rs1049498105 1204 dbSNP
rs577074651 1209 dbSNP
rs113514066 1215 dbSNP
rs562325938 1220 dbSNP
rs570647306 1221 dbSNP
rs974778599 1223 dbSNP
rs1193192180 1228 dbSNP
rs1265355542 1234 dbSNP
rs1440569174 1238 dbSNP
rs965878365 1240 dbSNP
rs911687135 1241 dbSNP
rs188563804 1243 dbSNP
rs956113646 1244 dbSNP
rs369686872 1250 dbSNP
rs1257149611 1251 dbSNP
rs567702934 1254 dbSNP
rs1290333079 1255 dbSNP
rs1045757155 1261 dbSNP
rs1385743932 1262 dbSNP
rs1324047445 1263 dbSNP
rs1347350693 1264 dbSNP
rs950139636 1267 dbSNP
rs16937130 1270 dbSNP
rs1279018586 1272 dbSNP
rs1230452537 1284 dbSNP
rs1022745765 1289 dbSNP
rs537937837 1293 dbSNP
rs1014000813 1295 dbSNP
rs896668942 1306 dbSNP
rs780668135 1313 dbSNP
rs1005141420 1325 dbSNP
rs1378659472 1330 dbSNP
rs73293508 1334 dbSNP
rs1049312610 1342 dbSNP
rs116102183 1346 dbSNP
rs1379773594 1349 dbSNP
rs775641911 1350 dbSNP
rs1252982291 1352 dbSNP
rs532371834 1354 dbSNP
rs560456000 1356 dbSNP
rs546903459 1357 dbSNP
rs1366352828 1360 dbSNP
rs530047779 1361 dbSNP
rs1163313944 1364 dbSNP
rs1373654160 1366 dbSNP
rs1407919388 1370 dbSNP
rs967538391 1373 dbSNP
rs1350821960 1383 dbSNP
rs759646816 1387 dbSNP
rs149590063 1390 dbSNP
rs1382460893 1391 dbSNP
rs779233753 1394 dbSNP
rs1245864528 1399 dbSNP
rs546319019 1400 dbSNP
rs1017943190 1403 dbSNP
rs4979863 1404 dbSNP
rs888126277 1407 dbSNP
rs1255966379 1411 dbSNP
rs1386547998 1412 dbSNP
rs576440111 1412 dbSNP
rs1427275794 1414 dbSNP
rs562842845 1418 dbSNP
rs753799803 1419 dbSNP
rs1300840774 1420 dbSNP
rs1378223883 1428 dbSNP
rs1404666332 1430 dbSNP
rs1256112743 1432 dbSNP
rs200210805 1433 dbSNP
rs1022613203 1437 dbSNP
rs1227764828 1443 dbSNP
rs1014015233 1445 dbSNP
rs1283496798 1446 dbSNP
rs960023659 1455 dbSNP
rs554168797 1456 dbSNP
rs1322052671 1458 dbSNP
rs1015335231 1463 dbSNP
rs74144723 1464 dbSNP
rs1394154817 1470 dbSNP
rs1354820536 1475 dbSNP
rs150427150 1477 dbSNP
rs1400742965 1478 dbSNP
rs1390302500 1481 dbSNP
rs1430206040 1483 dbSNP
rs1221408076 1493 dbSNP
rs1173946527 1499 dbSNP
rs1049326963 1500 dbSNP
rs1358345302 1500 dbSNP
rs995019839 1503 dbSNP
rs1338867371 1509 dbSNP
rs1386762709 1513 dbSNP
rs397728067 1516 dbSNP
rs534199043 1516 dbSNP
rs1364259625 1528 dbSNP
rs3839927 1528 dbSNP
rs56816269 1528 dbSNP
rs140570536 1542 dbSNP
rs1160037195 1543 dbSNP
rs1225770442 1556 dbSNP
rs377166084 1557 dbSNP
rs944801382 1561 dbSNP
rs554509628 1575 dbSNP
rs1053208712 1577 dbSNP
rs760646405 1580 dbSNP
rs764204604 1589 dbSNP
rs1242189062 1591 dbSNP
rs183695397 1594 dbSNP
rs1189337492 1597 dbSNP
rs934515085 1607 dbSNP
rs1424376515 1620 dbSNP
rs1433510373 1622 dbSNP
rs925798013 1623 dbSNP
rs922759899 1627 dbSNP
rs1167356289 1632 dbSNP
rs1346982495 1636 dbSNP
rs1434407563 1642 dbSNP
rs1293417471 1659 dbSNP
rs976949924 1666 dbSNP
rs1407352252 1667 dbSNP
rs1286814861 1668 dbSNP
rs1391978736 1672 dbSNP
rs1227381588 1673 dbSNP
rs568907490 1674 dbSNP
rs1474509828 1676 dbSNP
rs1284534065 1684 dbSNP
rs978689685 1685 dbSNP
rs1318127392 1687 dbSNP
rs1417842684 1695 dbSNP
rs72818290 1697 dbSNP
rs1246001592 1701 dbSNP
rs1490485695 1709 dbSNP
rs1201595882 1715 dbSNP
rs1249338872 1719 dbSNP
rs1472151701 1726 dbSNP
rs1018015858 1731 dbSNP
rs1410480961 1743 dbSNP
rs984288760 1745 dbSNP
rs952377797 1754 dbSNP
rs112508861 1755 dbSNP
rs994094372 1757 dbSNP
rs992526313 1759 dbSNP
rs566652816 1769 dbSNP
rs1350191487 1772 dbSNP
rs1410831907 1774 dbSNP
rs1372950739 1800 dbSNP
rs1488608016 1804 dbSNP
rs906492698 1804 dbSNP
rs1375096747 1812 dbSNP
rs1024750066 1816 dbSNP
rs546866454 1824 dbSNP
rs1012058011 1825 dbSNP
rs1015783691 1827 dbSNP
rs1266991298 1832 dbSNP
rs193031758 1833 dbSNP
rs189138597 1835 dbSNP
rs950960391 1838 dbSNP
rs202162509 1839 dbSNP
rs1220428332 1845 dbSNP
rs995054111 1848 dbSNP
rs1042146095 1849 dbSNP
rs922874153 1856 dbSNP
rs1426639510 1859 dbSNP
rs1167187169 1860 dbSNP
rs900729736 1861 dbSNP
rs113642009 1863 dbSNP
rs911398997 1865 dbSNP
rs1357824140 1874 dbSNP
rs1391810511 1878 dbSNP
rs868171713 1886 dbSNP
rs112598645 1887 dbSNP
rs866074507 1888 dbSNP
rs1394346778 1895 dbSNP
rs61859928 1903 dbSNP
rs1295249760 1908 dbSNP
rs1053643999 1915 dbSNP
rs934735825 1919 dbSNP
rs116543832 1926 dbSNP
rs545875386 1929 dbSNP
rs1274854988 1936 dbSNP
rs532497552 1937 dbSNP
rs560310052 1938 dbSNP
rs1012126766 1941 dbSNP
rs948526057 1942 dbSNP
rs1243980122 1943 dbSNP
rs1446477115 1958 dbSNP
rs915867929 1959 dbSNP
rs1191938186 1970 dbSNP
rs566144889 1971 dbSNP
rs1170211309 1974 dbSNP
rs1400442467 1979 dbSNP
rs1414268520 1981 dbSNP
rs1269085841 1997 dbSNP
rs575031156 2001 dbSNP
rs866616535 2002 dbSNP
rs1258493441 2004 dbSNP
rs908172393 2005 dbSNP
rs546158167 2007 dbSNP
rs1200394758 2009 dbSNP
rs1041703296 2011 dbSNP
rs773235848 2025 dbSNP
rs769459347 2034 dbSNP
rs1342532845 2037 dbSNP
rs1010632145 2049 dbSNP
rs1268487274 2057 dbSNP
rs879590737 2058 dbSNP
rs554987692 2060 dbSNP
rs901189552 2063 dbSNP
rs142485283 2064 dbSNP
rs575117779 2065 dbSNP
rs1303725657 2066 dbSNP
rs1376469616 2072 dbSNP
rs1477879304 2074 dbSNP
rs148823023 2081 dbSNP
rs1177574412 2085 dbSNP
rs1009140619 2095 dbSNP
rs1431954322 2100 dbSNP
rs1370646207 2104 dbSNP
rs942930891 2119 dbSNP
rs1383539618 2120 dbSNP
rs890467511 2123 dbSNP
rs911389080 2124 dbSNP
rs1467642167 2132 dbSNP
rs1049071605 2139 dbSNP
rs931063980 2140 dbSNP
rs1031650063 2152 dbSNP
rs1435729572 2159 dbSNP
rs1283645570 2161 dbSNP
rs1325498717 2170 dbSNP
rs538737909 2175 dbSNP
rs1378893772 2185 dbSNP
rs1351447900 2187 dbSNP
rs1206999480 2220 dbSNP
rs1265419590 2222 dbSNP
rs1451506590 2223 dbSNP
rs1200865184 2227 dbSNP
rs1191311343 2238 dbSNP
rs780909665 2239 dbSNP
rs1043157502 2242 dbSNP
rs1156413805 2256 dbSNP
rs1362894518 2261 dbSNP
rs1012776983 2264 dbSNP
rs970333016 2269 dbSNP
rs566609048 2273 dbSNP
rs746667390 2274 dbSNP
rs1423920476 2276 dbSNP
rs543302660 2278 dbSNP
rs1303745406 2290 dbSNP
rs1180347032 2291 dbSNP
rs908206946 2294 dbSNP
rs1407801817 2301 dbSNP
rs779286803 2315 dbSNP
rs1046695564 2317 dbSNP
rs930966999 2329 dbSNP
rs1241497309 2337 dbSNP
rs1263755871 2353 dbSNP
rs959317638 2360 dbSNP
rs1272260241 2370 dbSNP
rs1195268512 2380 dbSNP
rs1294592175 2382 dbSNP
rs1482254773 2391 dbSNP
rs1181934920 2392 dbSNP
rs1345755445 2401 dbSNP
rs919716715 2402 dbSNP
rs553160987 2403 dbSNP
rs757592244 2412 dbSNP
rs113517478 2413 dbSNP
rs964880033 2419 dbSNP
rs73293507 2420 dbSNP
rs1041107557 2421 dbSNP
rs1297364903 2424 dbSNP
rs1397030369 2425 dbSNP
rs1393349919 2431 dbSNP
rs12853 2435 dbSNP
rs774915210 2441 dbSNP
rs1397148802 2442 dbSNP
rs1317716979 2454 dbSNP
rs1403649516 2455 dbSNP
rs149688272 2458 dbSNP
rs1433709917 2459 dbSNP
rs998904344 2461 dbSNP
rs201898376 2471 dbSNP
rs1481856117 2474 dbSNP
rs530868533 2487 dbSNP
rs1380589852 2490 dbSNP
rs897335018 2500 dbSNP
rs1160213804 2511 dbSNP
rs1183648633 2513 dbSNP
rs1386604401 2526 dbSNP
rs1447579629 2533 dbSNP
rs1169725567 2542 dbSNP
rs569136173 2547 dbSNP
rs189976119 2548 dbSNP
rs1188104924 2555 dbSNP
rs1301274978 2555 dbSNP
rs1405652489 2557 dbSNP
rs185660412 2560 dbSNP
rs1338746772 2568 dbSNP
rs1259701438 2570 dbSNP
rs894331229 2571 dbSNP
rs1056925928 2579 dbSNP
rs1363194735 2579 dbSNP
rs990473687 2579 dbSNP
rs1003212042 2584 dbSNP
rs76349483 2595 dbSNP
rs1208900077 2597 dbSNP
rs887065200 2599 dbSNP
rs1262968310 2600 dbSNP
rs568696935 2602 dbSNP
rs931003928 2611 dbSNP
rs925166692 2620 dbSNP
rs1244432340 2621 dbSNP
rs759719041 2628 dbSNP
rs1463172321 2630 dbSNP
rs1225717107 2632 dbSNP
rs1348926806 2639 dbSNP
rs1262378039 2640 dbSNP
rs919582639 2647 dbSNP
rs979384042 2648 dbSNP
rs1357984987 2655 dbSNP
rs1428387348 2679 dbSNP
rs1310526449 2684 dbSNP
rs966909304 2687 dbSNP
rs1178920078 2691 dbSNP
rs1386466732 2692 dbSNP
rs1430107789 2698 dbSNP
rs867391014 2699 dbSNP
rs540400801 2700 dbSNP
rs35596813 2701 dbSNP
rs397728947 2701 dbSNP
rs530248320 2701 dbSNP
rs1491324071 2702 dbSNP
rs561565813 2709 dbSNP
rs548856778 2710 dbSNP
rs1163695008 2713 dbSNP
rs1242242599 2714 dbSNP
rs1486788706 2714 dbSNP
rs5786398 2714 dbSNP
rs869272597 2714 dbSNP
rs1201774415 2715 dbSNP
rs1006920121 2716 dbSNP
rs1019615288 2716 dbSNP
rs1159890493 2718 dbSNP
rs1473731191 2718 dbSNP
rs1456828566 2719 dbSNP
rs1303095811 2720 dbSNP
rs889813016 2722 dbSNP
rs1346472630 2724 dbSNP
rs544558065 2726 dbSNP
rs1370695792 2743 dbSNP
rs1222890365 2748 dbSNP
rs1415652589 2757 dbSNP
rs1284339668 2758 dbSNP
rs1185866179 2761 dbSNP
rs1485363298 2768 dbSNP
rs1027621589 2771 dbSNP
rs751810984 2783 dbSNP
rs575942467 2784 dbSNP
rs1218145536 2794 dbSNP
rs910715695 2796 dbSNP
rs897312482 2805 dbSNP
rs1445503197 2810 dbSNP
rs1283999995 2819 dbSNP
rs1163462735 2833 dbSNP
rs987689679 2842 dbSNP
rs182827623 2847 dbSNP
rs1427159763 2864 dbSNP
rs924910839 2867 dbSNP
rs1306525162 2869 dbSNP
rs545028852 2872 dbSNP
rs896262533 2891 dbSNP
rs117017790 2894 dbSNP
rs139932809 2895 dbSNP
rs762796952 2901 dbSNP
rs773285767 2903 dbSNP
rs1353038943 2909 dbSNP
rs979721582 2912 dbSNP
rs1013008601 2925 dbSNP
rs575270063 2928 dbSNP
rs958744546 2928 dbSNP
rs1344301180 2934 dbSNP
rs1323947377 2936 dbSNP
rs1036177343 2942 dbSNP
rs1205409522 2944 dbSNP
rs1329853855 2952 dbSNP
rs191423532 2955 dbSNP
rs1462859756 2959 dbSNP
rs1392060597 2968 dbSNP
rs536410871 2969 dbSNP
rs1385980678 2970 dbSNP
rs1446966216 2972 dbSNP
rs1166716521 2977 dbSNP
rs567331675 2982 dbSNP
rs975943243 2987 dbSNP
rs1002749862 2991 dbSNP
rs1188425256 3003 dbSNP
rs1450064802 3009 dbSNP
rs1335493525 3016 dbSNP
rs886924270 3017 dbSNP
rs749393062 3031 dbSNP
rs1248008051 3032 dbSNP
rs995356950 3041 dbSNP
rs985555588 3053 dbSNP
rs954149538 3061 dbSNP
rs1222734297 3065 dbSNP
rs1214969152 3076 dbSNP
rs1470071882 3107 dbSNP
rs1274918746 3109 dbSNP
rs898187039 3121 dbSNP
rs138081844 3135 dbSNP
rs1039306718 3138 dbSNP
rs942361286 3144 dbSNP
rs1191581168 3153 dbSNP
rs16937126 3155 dbSNP
rs1475917476 3159 dbSNP
rs1051266718 3160 dbSNP
rs933529943 3162 dbSNP
rs1169983493 3169 dbSNP
rs1427721047 3174 dbSNP
rs1467891686 3178 dbSNP
rs1015694804 3180 dbSNP
rs1465532126 3197 dbSNP
rs1397305748 3204 dbSNP
rs1212344887 3214 dbSNP
rs1013682334 3220 dbSNP
rs1275038652 3221 dbSNP
rs1325765378 3223 dbSNP
rs1442684391 3227 dbSNP
rs1368448345 3229 dbSNP
rs896670646 3237 dbSNP
rs769796114 3238 dbSNP
rs977687212 3239 dbSNP
rs1343467557 3252 dbSNP
rs1223068914 3261 dbSNP
rs1324980167 3265 dbSNP
rs1263995162 3268 dbSNP
rs1466074428 3281 dbSNP
rs947578750 3289 dbSNP
rs1054766629 3295 dbSNP
rs1283709526 3301 dbSNP
rs761794836 3303 dbSNP
rs903517376 3310 dbSNP
rs1043434911 3311 dbSNP
rs1408315229 3319 dbSNP
rs74625762 3331 dbSNP
rs1467306543 3332 dbSNP
rs1156275707 3334 dbSNP
rs1191940470 3339 dbSNP
rs1383697906 3345 dbSNP
rs1299973996 3352 dbSNP
rs774451853 3352 dbSNP
rs913845442 3362 dbSNP
rs1251450593 3364 dbSNP
rs991522444 3365 dbSNP
rs1284105105 3367 dbSNP
rs1040334056 3383 dbSNP
rs1237205015 3398 dbSNP
rs958956118 3399 dbSNP
rs1035803091 3408 dbSNP
rs1279022925 3418 dbSNP
rs1351513716 3418 dbSNP
rs571248716 3419 dbSNP
rs552106401 3420 dbSNP
rs1490275775 3425 dbSNP
rs951262298 3430 dbSNP
rs1223662440 3431 dbSNP
rs1271552983 3434 dbSNP
rs944494331 3439 dbSNP
rs1179289911 3440 dbSNP
rs1362650639 3458 dbSNP
rs1203072748 3468 dbSNP
rs57463230 3472 dbSNP
rs61474252 3475 dbSNP
rs1306367699 3476 dbSNP
rs910395214 3476 dbSNP
rs1025878058 3480 dbSNP
rs995387793 3484 dbSNP
rs1423991058 3486 dbSNP
rs1303498452 3489 dbSNP
rs954189145 3494 dbSNP
rs538670585 3495 dbSNP
rs1328442388 3496 dbSNP
rs1018142977 3497 dbSNP
rs1006534562 3501 dbSNP
rs566593581 3502 dbSNP
rs1247438162 3512 dbSNP
rs1294382008 3513 dbSNP
rs1479868906 3513 dbSNP
rs1302394234 3514 dbSNP
rs1050876913 3516 dbSNP
rs1447304989 3521 dbSNP
rs546765175 3524 dbSNP
rs1013796959 3525 dbSNP
rs1375397391 3527 dbSNP
rs960819652 3536 dbSNP
rs1164150525 3539 dbSNP
rs1033851268 3542 dbSNP
rs1002356252 3555 dbSNP
rs1441419280 3558 dbSNP
rs370665368 3567 dbSNP
rs1449335242 3570 dbSNP
rs1174344293 3577 dbSNP
rs1043769477 3579 dbSNP
rs530242788 3580 dbSNP
rs1453933805 3583 dbSNP
rs147881745 3583 dbSNP
rs1315437629 3590 dbSNP
rs561323559 3598 dbSNP
rs1227181486 3611 dbSNP
rs903353873 3619 dbSNP
rs892151164 3620 dbSNP
rs1393558174 3631 dbSNP
rs1041873241 3633 dbSNP
rs947528613 3643 dbSNP
rs914866768 3645 dbSNP
rs1040282060 3656 dbSNP
rs1175937875 3661 dbSNP
rs1345473883 3662 dbSNP
rs1426715488 3668 dbSNP
rs1480596818 3671 dbSNP
rs551198875 3676 dbSNP
rs546458243 3678 dbSNP
rs1212474986 3681 dbSNP
rs1405354138 3686 dbSNP
rs928598245 3697 dbSNP
rs531067620 3698 dbSNP
rs1305055400 3702 dbSNP
rs1302492772 3704 dbSNP
rs1050301980 3705 dbSNP
rs1296732816 3706 dbSNP
rs932710032 3710 dbSNP
rs981569858 3711 dbSNP
rs1318449274 3714 dbSNP
rs565578645 3723 dbSNP
rs1210181791 3724 dbSNP
rs1257292206 3727 dbSNP
rs1304616472 3733 dbSNP
rs918428810 3734 dbSNP
rs6858 3736 dbSNP
rs1262092370 3737 dbSNP
rs961324298 3752 dbSNP
rs962499157 3764 dbSNP
rs1018173918 3765 dbSNP
rs1428881664 3768 dbSNP
rs1006730840 3769 dbSNP
rs1178288243 3770 dbSNP
rs960981228 3774 dbSNP
rs572889462 3778 dbSNP
rs375410917 3779 dbSNP
rs768644098 3784 dbSNP
rs576080556 3788 dbSNP
rs999290029 3789 dbSNP
rs902294457 3794 dbSNP
rs1043494687 3798 dbSNP
rs768178528 3799 dbSNP
rs1219518738 3801 dbSNP
rs748375312 3802 dbSNP
rs1157468089 3804 dbSNP
rs542335363 3810 dbSNP
rs573727030 3811 dbSNP
rs746687056 3814 dbSNP
rs376437767 3818 dbSNP
rs1473914383 3821 dbSNP
rs770007398 3822 dbSNP
rs1478476931 3834 dbSNP
rs370261124 3839 dbSNP
rs1256217112 3840 dbSNP
rs1193200072 3842 dbSNP
rs1205293888 3848 dbSNP
rs556867867 3849 dbSNP
rs541141968 3855 dbSNP
rs11002951 3856 dbSNP
rs577488129 3862 dbSNP
rs1382678774 3867 dbSNP
rs1008805862 3868 dbSNP
rs929987778 3869 dbSNP
rs918693643 3873 dbSNP
rs1366649070 3877 dbSNP
rs867759121 3878 dbSNP
rs974113695 3880 dbSNP
rs557647030 3887 dbSNP
rs962528720 3891 dbSNP
rs6480934 3892 dbSNP
rs372562657 3894 dbSNP
rs1292758675 3895 dbSNP
rs899000313 3900 dbSNP
rs1387494517 3901 dbSNP
rs566509149 3906 dbSNP
rs1038415310 3908 dbSNP
rs1290740770 3910 dbSNP
rs1451978540 3919 dbSNP
rs1224001463 3924 dbSNP
rs771312204 3927 dbSNP
rs781255204 3928 dbSNP
rs571911703 3930 dbSNP
rs1029571631 3934 dbSNP
rs940146098 3940 dbSNP
rs1163523972 3943 dbSNP
rs1287465280 3958 dbSNP
rs749599872 3960 dbSNP
rs908544797 3961 dbSNP
rs547021731 3965 dbSNP
rs966349312 3966 dbSNP
rs1022083468 3969 dbSNP
rs536341560 3970 dbSNP
rs939589131 3977 dbSNP
rs567762133 3979 dbSNP
rs865784163 3990 dbSNP
rs1474518097 3991 dbSNP
rs1416437163 4001 dbSNP
rs80126415 4016 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124A_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + A ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccuuaccguCCCUUUa 5'
                         |||||| 
Target 5' ------------uguGGGAAAa 3'
1 - 10
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccuuaccguCCCUUUa 5'
                         |||||| 
Target 5' -----------cuguGGGAAAa 3'
1 - 11
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_153367 | 3UTR | AGGGAAAGCAGGGAGUCUGGGGCUUUUUGCAGGCGGGCCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903828
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_9124
Location of target site NM_153367 | 3UTR | AGGCCAGGGAAAGCAGGGAGUCUGGGGCUUUUUGCAGGCGGGCCUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset Chi_124A_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + A
Location of target site ENST00000372336.3 | 3UTR | UGUGGGAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000372336.3 | 3UTR | CUGUGGGAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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