pre-miRNA Information
pre-miRNA hsa-mir-6737   
Genomic Coordinates chr1: 153962351 - 153962420
Description Homo sapiens miR-6737 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6737-5p
Sequence 6| UUGGGGUGGUCGGCCCUGGAG |26
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766338599 4 dbSNP
rs765728788 7 dbSNP
rs757341439 9 dbSNP
rs539511149 11 dbSNP
rs764259486 12 dbSNP
rs988937601 21 dbSNP
Putative Targets

Gene Information
Gene Symbol FGF19   
Synonyms -
Description fibroblast growth factor 19
Transcript NM_005117   
Expression
Putative miRNA Targets on FGF19
3'UTR of FGF19
(miRNA target sites are highlighted)
>FGF19|NM_005117|3'UTR
   1 CTGAGACCATGCCCGGGCCTCTTCACTGCTGCCAGGGGCTGTGGTACCTGCAGCGTGGGGGACGTGCTTCTACAAGAACA
  81 GTCCTGAGTCCACGTTCTGTTTAGCTTTAGGAAGAAACATCTAGAAGTTGTACATATTCAGAGTTTTCCATTGGCAGTGC
 161 CAGTTTCTAGCCAATAGACTTGTCTGATCATAACATTGTAAGCCTGTAGCTTGCCCAGCTGCTGCCTGGGCCCCCATTCT
 241 GCTCCCTCGAGGTTGCTGGACAAGCTGCTGCACTGTCTCAGTTCTGCTTGAATACCTCCATCGATGGGGAACTCACTTCC
 321 TTTGGAAAAATTCTTATGTCAAGCTGAAATTCTCTAATTTTTTCTCATCACTTCCCCAGGAGCAGCCAGAAGACAGGCAG
 401 TAGTTTTAATTTCAGGAACAGGTGATCCACTCTGTAAAACAGCAGGTAAATTTCACTCAACCCCATGTGGGAATTGATCT
 481 ATATCTCTACTTCCAGGGACCATTTGCCCTTCCCAAATCCCTCCAGGCCAGAACTGACTGGAGCAGGCATGGCCCACCAG
 561 GCTTCAGGAGTAGGGGAAGCCTGGAGCCCCACTCCAGCCCTGGGACAACTTGAGAATTCCCCCTGAGGCCAGTTCTGTCA
 641 TGGATGCTGTCCTGAGAATAACTTGCTGTCCCGGTGTCACCTGCTTCCATCTCCCAGCCCACCAGCCCTCTGCCCACCTC
 721 ACATGCCTCCCCATGGATTGGGGCCTCCCAGGCCCCCCACCTTATGTCAACCTGCACTTCTTGTTCAAAAATCAGGAAAA
 801 GAAAAGATTTGAAGACCCCAAGTCTTGTCAATAACTTGCTGTGTGGAAGCAGCGGGGGAAGACCTAGAACCCTTTCCCCA
 881 GCACTTGGTTTTCCAACATGATATTTATGAGTAATTTATTTTGATATGTACATCTCTTATTTTCTTACATTATTTATGCC
 961 CCCAAATTATATTTATGTATGTAAGTGAGGTTTGTTTTGTATATTAAAATGGAGTTTGTTTGTAAAAAAAAAAAAAAAAA
1041 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            |::| |||  ||||:||| 
Target 5' gcCTGGAGCC--CCACTCCAg 3'
579 - 597 143.00 -24.00
2
miRNA  3' gaGGUC--CCGGCUGGUGGGGUu 5'
            ||||    |:| |||||:|| 
Target 5' caCCAGCCCTCTGCCCACCTCAc 3'
700 - 722 141.00 -20.80
3
miRNA  3' gaGGUCCCGGCUGGUGGGGUu 5'
            ||| ||||  |||||::| 
Target 5' tcCCA-GGCCCCCCACCTTAt 3'
746 - 765 134.00 -21.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30496071 14 COSMIC
COSN17182814 35 COSMIC
COSN30502342 54 COSMIC
COSN31499862 154 COSMIC
COSN28242964 696 COSMIC
COSN20108467 885 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1200210204 2 dbSNP
rs769260055 7 dbSNP
rs1315971502 8 dbSNP
rs749561746 11 dbSNP
rs1019112835 12 dbSNP
rs1378796173 13 dbSNP
rs1277691739 14 dbSNP
rs200919218 15 dbSNP
rs1348060910 17 dbSNP
rs756366989 19 dbSNP
rs1444535859 25 dbSNP
rs1337426850 28 dbSNP
rs1329325635 32 dbSNP
rs750699805 35 dbSNP
rs1400350130 36 dbSNP
rs1314931160 37 dbSNP
rs781615836 41 dbSNP
rs1379828609 44 dbSNP
rs1156912647 47 dbSNP
rs1469283551 48 dbSNP
rs886599661 54 dbSNP
rs568253878 55 dbSNP
rs185560971 61 dbSNP
rs898180930 63 dbSNP
rs1055438741 64 dbSNP
rs1217954042 66 dbSNP
rs73524727 67 dbSNP
rs570500898 69 dbSNP
rs948787955 75 dbSNP
rs1334654680 79 dbSNP
rs1446016594 79 dbSNP
rs1300137649 83 dbSNP
rs1351139372 86 dbSNP
rs564723134 93 dbSNP
rs914632483 94 dbSNP
rs1326360248 99 dbSNP
rs1224663860 103 dbSNP
rs552560069 118 dbSNP
rs528016672 128 dbSNP
rs1441065365 144 dbSNP
rs928504512 151 dbSNP
rs990197740 152 dbSNP
rs956109905 160 dbSNP
rs1031818312 163 dbSNP
rs1409661590 166 dbSNP
rs986978208 171 dbSNP
rs1297494219 178 dbSNP
rs1173107883 182 dbSNP
rs945905943 186 dbSNP
rs560188652 190 dbSNP
rs1412578081 197 dbSNP
rs1320646827 203 dbSNP
rs955798234 204 dbSNP
rs1028600195 209 dbSNP
rs1371463426 217 dbSNP
rs541888974 221 dbSNP
rs574497157 224 dbSNP
rs1347482254 226 dbSNP
rs996915956 231 dbSNP
rs913055500 232 dbSNP
rs1274804723 234 dbSNP
rs1343269775 242 dbSNP
rs898196291 248 dbSNP
rs1016564218 249 dbSNP
rs562523691 256 dbSNP
rs1342519622 277 dbSNP
rs544318403 279 dbSNP
rs1248917996 281 dbSNP
rs1490703623 282 dbSNP
rs957430920 296 dbSNP
rs1476907317 298 dbSNP
rs886878777 302 dbSNP
rs1056197937 303 dbSNP
rs1406361541 314 dbSNP
rs1367829123 316 dbSNP
rs1167015787 317 dbSNP
rs939228096 331 dbSNP
rs966068240 333 dbSNP
rs905107032 340 dbSNP
rs1323448517 344 dbSNP
rs1188379631 347 dbSNP
rs1433323612 353 dbSNP
rs757274283 355 dbSNP
rs71465439 358 dbSNP
rs1477057131 363 dbSNP
rs1244949041 366 dbSNP
rs1019646794 369 dbSNP
rs1005121503 374 dbSNP
rs1272080016 377 dbSNP
rs950971962 380 dbSNP
rs1289052855 385 dbSNP
rs1293668348 391 dbSNP
rs1449728976 395 dbSNP
rs1195253381 397 dbSNP
rs576930378 403 dbSNP
rs995267757 411 dbSNP
rs748111834 425 dbSNP
rs1295787916 427 dbSNP
rs898213737 428 dbSNP
rs1055471301 429 dbSNP
rs914535926 430 dbSNP
rs1388677971 438 dbSNP
rs1321837680 446 dbSNP
rs558747482 454 dbSNP
rs1388313461 456 dbSNP
rs1215850468 458 dbSNP
rs1054476654 461 dbSNP
rs1294919703 462 dbSNP
rs934701983 463 dbSNP
rs924716966 465 dbSNP
rs182385577 474 dbSNP
rs1046091576 476 dbSNP
rs987359028 481 dbSNP
rs1210465479 485 dbSNP
rs1264967469 489 dbSNP
rs955608473 493 dbSNP
rs749088157 497 dbSNP
rs1464255648 498 dbSNP
rs1206650238 499 dbSNP
rs552185957 513 dbSNP
rs1424550434 514 dbSNP
rs921509873 516 dbSNP
rs1187125810 519 dbSNP
rs61882811 521 dbSNP
rs1346925331 523 dbSNP
rs755766481 527 dbSNP
rs752431932 531 dbSNP
rs1455964785 535 dbSNP
rs767243993 536 dbSNP
rs139135809 541 dbSNP
rs1370909024 543 dbSNP
rs1003847322 546 dbSNP
rs974846087 553 dbSNP
rs1229749894 555 dbSNP
rs951121451 565 dbSNP
rs563262796 573 dbSNP
rs1226504919 576 dbSNP
rs1257482596 578 dbSNP
rs1200049889 579 dbSNP
rs1483468300 579 dbSNP
rs1254387388 580 dbSNP
rs535416604 581 dbSNP
rs1484066798 586 dbSNP
rs1183065568 587 dbSNP
rs1251724811 588 dbSNP
rs1003778832 591 dbSNP
rs568116446 594 dbSNP
rs911878843 596 dbSNP
rs751140818 603 dbSNP
rs904989882 610 dbSNP
rs950915778 613 dbSNP
rs374099120 619 dbSNP
rs1171616376 622 dbSNP
rs1399686789 625 dbSNP
rs973529260 630 dbSNP
rs1010799174 632 dbSNP
rs959524881 635 dbSNP
rs893738414 638 dbSNP
rs1303360335 642 dbSNP
rs1054444939 662 dbSNP
rs538352262 668 dbSNP
rs1232329207 670 dbSNP
rs750570172 672 dbSNP
rs570935598 673 dbSNP
rs906889086 680 dbSNP
rs948992 692 dbSNP
rs117514638 693 dbSNP
rs921405353 698 dbSNP
rs976005823 699 dbSNP
rs891672878 705 dbSNP
rs1054295384 706 dbSNP
rs1432952020 707 dbSNP
rs1197278319 708 dbSNP
rs1285962437 726 dbSNP
rs143309955 731 dbSNP
rs910163810 732 dbSNP
rs1373638220 733 dbSNP
rs1299612672 738 dbSNP
rs548904742 749 dbSNP
rs776923150 753 dbSNP
rs1295199751 754 dbSNP
rs1034655941 760 dbSNP
rs1039551421 777 dbSNP
rs1176688203 783 dbSNP
rs1298836860 786 dbSNP
rs1470943640 791 dbSNP
rs1431501435 792 dbSNP
rs1157073249 795 dbSNP
rs867298817 801 dbSNP
rs776387709 806 dbSNP
rs944784230 814 dbSNP
rs911893554 817 dbSNP
rs1472357309 841 dbSNP
rs764464179 844 dbSNP
rs35366482 851 dbSNP
rs529688643 853 dbSNP
rs562485781 858 dbSNP
rs1450515298 868 dbSNP
rs1011183676 870 dbSNP
rs1389220555 872 dbSNP
rs1426210662 873 dbSNP
rs893707124 880 dbSNP
rs1349969137 883 dbSNP
rs1457295712 884 dbSNP
rs202153217 887 dbSNP
rs1030965346 888 dbSNP
rs1237320563 889 dbSNP
rs920886485 892 dbSNP
rs1297124836 898 dbSNP
rs998850748 903 dbSNP
rs973645241 904 dbSNP
rs959557436 920 dbSNP
rs1313453461 927 dbSNP
rs1321220864 928 dbSNP
rs1265645303 937 dbSNP
rs760846048 946 dbSNP
rs1219958355 947 dbSNP
rs775542178 950 dbSNP
rs543959862 957 dbSNP
rs576896442 960 dbSNP
rs540764360 963 dbSNP
rs1317070676 988 dbSNP
rs1465612554 990 dbSNP
rs934068088 993 dbSNP
rs899929012 998 dbSNP
rs1039860131 1002 dbSNP
rs941555998 1008 dbSNP
rs1226317115 1019 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000294312.3 | 3UTR | UCAGGAAAAGAAAAGAUUUGAAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000294312.3 | 3UTR | AAAAGAUUUGAAGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
67 hsa-miR-6737-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066215 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT074413 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT125300 MID1IP1 MID1 interacting protein 1 2 2
MIRT153951 NCOA3 nuclear receptor coactivator 3 2 2
MIRT452776 FAM136A family with sequence similarity 136 member A 2 2
MIRT452977 CABP4 calcium binding protein 4 2 2
MIRT454128 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT455242 DDX39B DExD-box helicase 39B 2 10
MIRT459007 UQCRH ubiquinol-cytochrome c reductase hinge protein 2 2
MIRT459463 MUC17 mucin 17, cell surface associated 2 4
MIRT460871 UBE2S ubiquitin conjugating enzyme E2 S 2 2
MIRT461264 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 2
MIRT464540 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT465268 TRIM28 tripartite motif containing 28 2 2
MIRT465871 TMEM43 transmembrane protein 43 2 4
MIRT466228 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT468417 SETD1B SET domain containing 1B 2 2
MIRT468684 SEC22C SEC22 homolog C, vesicle trafficking protein 2 4
MIRT473399 MDM4 MDM4, p53 regulator 2 2
MIRT473517 MAX MYC associated factor X 2 2
MIRT474511 KLHDC8A kelch domain containing 8A 2 2
MIRT475801 HDGF heparin binding growth factor 2 2
MIRT479493 CDH6 cadherin 6 2 2
MIRT480770 BMP2 bone morphogenetic protein 2 2 2
MIRT481418 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT482966 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT483380 SPATA6 spermatogenesis associated 6 2 4
MIRT483677 CYP11A1 cytochrome P450 family 11 subfamily A member 1 2 2
MIRT484328 EPN1 epsin 1 2 4
MIRT484963 UCK1 uridine-cytidine kinase 1 2 2
MIRT485908 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT488149 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488943 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 6
MIRT491835 ZBTB7A zinc finger and BTB domain containing 7A 2 4
MIRT493026 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT499374 PLCG2 phospholipase C gamma 2 2 11
MIRT499723 USH1G USH1 protein network component sans 2 4
MIRT500349 ZNF385A zinc finger protein 385A 2 2
MIRT509574 HIST2H2AB histone cluster 2 H2A family member b 2 4
MIRT512794 GLRX glutaredoxin 2 2
MIRT513291 SETBP1 SET binding protein 1 2 2
MIRT515697 ZNF321P zinc finger protein 321, pseudogene 2 2
MIRT518255 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT522026 PAQR3 progestin and adipoQ receptor family member 3 2 4
MIRT523169 HIST3H3 histone cluster 3 H3 2 2
MIRT524036 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT533476 TRIM71 tripartite motif containing 71 2 2
MIRT541488 ADM adrenomedullin 2 2
MIRT553987 SRPR SRP receptor alpha subunit 2 2
MIRT571445 YKT6 YKT6 v-SNARE homolog 2 2
MIRT574889 Plcg2 phospholipase C, gamma 2 2 7
MIRT607544 GLI2 GLI family zinc finger 2 2 2
MIRT607688 MAPK10 mitogen-activated protein kinase 10 2 2
MIRT610072 CRLF1 cytokine receptor like factor 1 2 2
MIRT610573 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT614041 THBS2 thrombospondin 2 2 2
MIRT626318 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT634005 RIF1 replication timing regulatory factor 1 2 2
MIRT639619 FGF19 fibroblast growth factor 19 2 2
MIRT647343 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT689704 ATXN2 ataxin 2 2 2
MIRT691170 APOL6 apolipoprotein L6 2 2
MIRT693165 NPR1 natriuretic peptide receptor 1 2 2
MIRT711727 NUPL2 nucleoporin like 2 2 2
MIRT711806 ELN elastin 2 2
MIRT721546 FXN frataxin 2 2
MIRT722979 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6737 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-6737-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6737-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-6737-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-6737-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6737-5p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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