pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SRGAP2   
Synonyms ARHGAP34, FNBP2, SRGAP2A, SRGAP3
Description SLIT-ROBO Rho GTPase activating protein 2
Transcript NM_001170637   
Other Transcripts NM_015326   
Expression
Putative miRNA Targets on SRGAP2
3'UTR of SRGAP2
(miRNA target sites are highlighted)
>SRGAP2|NM_001170637|3'UTR
   1 GGGATAATAATTTAATTGTTCTAGACAAGGGGACTATAGGGACTGACTGTTATTAAAATCTTCCTATTTAACTAGCTTGG
  81 GGACTTCAGTTGAAAATTAGGTTCTAAGTTGTTCTTGCAGGAATTAGCCTCCCCGTCTCCCAAAACCTTGAGAATGAAGC
 161 CCTTGGTATCGCCTCTCCCTTCCCACTGCCCTCTGCTTCCCCCAGTCGTCGTAATTCAGCCAGCTGCAGTCCGTACCGTT
 241 CTTAGGTTAGCCAGAGACAGGTTTTCATTATCAGGTCACTGTGAAATCTGGTAAGGCAGTCCTGAGGACATGGGCTCAAG
 321 TCTCAGTCCCCTCAGACCACGGTGATGCCTTGACCAGATGGTTGGCTACTGCCATCCAGCTTTCAGTGGCATCTTGTTTT
 401 GGGAACTGATTATAGAGAATCATATATAGTCCAGTCTTCATTTTACATACACACACATATTTTACACACACACACATTTT
 481 ACACACACACACACACACACACACACACATATGTTTTTCTAGTCTCTGGCATGTGTAGCCTCTCCTGGTCATAGACCAGT
 561 CTCTTTGTAAGTTATTGTGGCAGTTCACACAGTAGCCACCAGGGGTCTCTGTTTCCATCACAAACTTTGTTCTGTCTGGG
 641 CCAGAGAACCTAGCCTTTGAAATCTCTCCATCATATGAAACATAACGGGATGGGACAATCCCGTAACCTGTTTGGGGTTG
 721 GGGGCTTTCTCTCTGTGTTCTTTCCATTGATGTGAATTGGTCATTGGTGTTTGCTCTTGCCTCTCCTCCATCCCCTAGAA
 801 GTACACCCCCGTCTTATTAAGGAGCTTTTAAAGTTTTTCTGAATGTATAGACATTTCTCGGGTTCCTACCTTTGTCTCTG
 881 ATGGACCATTTTCCATTTAAGACATTTTCCTGTATAAGACAGTTTTATAGCTGGTTCCTTTTAGGGTAAAGAGTCTTAAG
 961 AGAGTTTTATTGTGTCTATGGCAGGTTTGGGAAAGGTAAGAAATGGGTCCTTTTTCCTCCTAATGTTTTTGGCACTTAAA
1041 ACATAAAATTCATTATCCTATTAAAAAATTAAATTCAGCTTTGCTAATCCAGAAATTGTTCCCAAATGAAAACTTGTTTT
1121 AAGTCCACCCCTTAGTTTCCTTATTTTACAAGGTCTCTCTTCAGGGACCAACAGGGGCTTAGAGAGCCTTAGTTAGATTA
1201 AAGGGAGACCCTACCTCTTAAAACCAGTTTTCATTTATGCAAACAAGGACAATTAAGGGAACCCTGACCCCACAGGCTCT
1281 CAAGTCTTCCCAAGGCCAGAATCGAAAGAAAATTAAAATTTGAATGCTGAATATTCTGGCTCTACTCTGGCCTTTTTTCT
1361 GGTTCCCTTCCAAAATGCACAAATCATACCCTTGTCTGCTCCAATTCAGTCTCCAAACCTGGTGCCTGTGCTCCTGGCCC
1441 CCCTAGCATCATGCTATCCCAGGAGTATCAGGACCAGACACATCCACAGCCAGGCTCATGGGTCTCAGACAGCAACTTGA
1521 GTTAAAGCTGAAACTCATCCTTCTTCTCTGTGTTTTCTGGTTTAAAAGCTGCACTTATATTTTAGCCTTATTATTTTCTG
1601 TAGTTCCGGAGAGATGGTGGGTTGCCATTCTGGTAGGAAAATCTGAGTTTTCTTATCTTTGACCTAGAAGAGATTCTTTT
1681 TGGACCAACCTGCGAAATTGGTAGTTAGGTCTATGGAAAGTGGTAGGATTTTTTTTTTTTTAATCCTGTGCAAAGGAAAA
1761 GAGGTGCTTTGTGGGAAATCACTAATGAGAAGGCTAACCTGCAGCACCAGAGAAACCTTTCCAAGTGCTAGGCAGGAGAA
1841 CTGAAGAACTCTTTCAGTGAAGTGAGTCAGCCTAGAAGAGGCAACCCACAGTCTTGATTTTTGTTGCTGTTTCCTGACCT
1921 GTTCTTGCCTGTCACCTGGGCCTACACAGGTCCCAAGCCAACGGGGCTTTCATACCCAAGGATCTGTTTCCTTGCTGAAA
2001 ATGAAACCCTATCTTTCACTTTACATTCCTTTCAATCCAACTGATCAAAACTGGTACCCACACTTGCCCTTTCTCCCTCT
2081 CTCCAGCACACTCCCCTCTAAGAAAGTAAAAGCAAAGCTTTCTTAATGGCAACACTTTGGGCCTGTTCTGTTGCTCCTGC
2161 CTTATTTCTCTTTCAACCCTGTACATGACTCGTGTTCACCATCCCCTTGATCAGTGTCCATCCGCGCTAATTTGCATCAT
2241 GAACTGAACAGTGTGTGAGTGGTCACCTACTAAACCCAGCTCTGGGGGCAGAGCTGTCTTCCCCATCTCTGGTGCTCCTA
2321 ACACCTGTGAGATGGTCCTGTCGAGAGGACTAGGAACCGATAGGAGGAGAGTCCTTCTCGGCAGAGCTCACTGCAAACAA
2401 CTGGAATTGAGGTTGCACACTGTGATTTTTACACCGAAAAGCCAAAAGGAGCTGGCCATCCAGGGCCTAGGGAGACCAGC
2481 CTTCCTCAGCTATGCTTGCCGAAACCAGCATGATGCTTCAAAGAGCCCTGCTCCACCCCTCATGGCATGGATCCTTTTCC
2561 TGGTGTGGACTCTGAAGGGTCAGTCTTCGGGGAAGAGAGGTGGGGTGGGGCTACTAGCATCCCAATTTAGAAAATAGAGG
2641 AGTTTGTAGCCAGCAGCCTGTAAACTGGAAACACTGGTCTCAGCCAACCTCCTCAGGGCGCCCTGGCTTCTCCCCAAGGA
2721 GATGAGGAGCGGTGATGCCAGCACCGGGATGCGCAGAGCACTGGAAGGGCTGGTGCAGATCTACTTCCCATGCAGAAGAG
2801 AAGTCACATCTTCCAGGGAATCGCAATGTTGTGGCGTCTGACTTGTATGTCACATTTGTGTAAAATGGTATATTCTTTAA
2881 AATAGTGTTGATAACTGGAATATTGTATGTATGCTTGGAGATGCTTTGTGTGAACCTAAGACTGTCACTCAACAGATGTT
2961 GGATTGGGGAAAATCCAAAGCACAACTTCAAAATAAAATACATTTTTAGGTTTCGATGCTGCAAAAAAAAAAAAAAAAAA
3041 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cacacGAGAGACCAGUUGGUAg 5'
               :|||||  |||||| | 
Target 5' cttatTTCTCT-TTCAACCCTg 3'
2161 - 2181 128.00 -11.32
2
miRNA  3' cacACGAGAGACCAGUUGGUAg 5'
             || |||||| | :||||| 
Target 5' cttTG-TCTCTGATGGACCATt 3'
870 - 890 126.00 -15.60
3
miRNA  3' cacACGAGAGACC-AGUUGGuag 5'
             | ||:|:|||  |||||   
Target 5' agaTTCTTTTTGGACCAACCtgc 3'
1671 - 1693 123.00 -14.32
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM6790229 1 COSMIC
COSN30459476 64 COSMIC
COSN30459097 81 COSMIC
COSN30189584 83 COSMIC
COSN30484162 115 COSMIC
COSN30455655 132 COSMIC
COSN28863115 135 COSMIC
COSN30528418 148 COSMIC
COSN30151800 151 COSMIC
COSN30461846 179 COSMIC
COSN30146279 194 COSMIC
COSN30125741 211 COSMIC
COSN7199442 427 COSMIC
COSN6402220 512 COSMIC
COSN6439009 810 COSMIC
COSN31601305 817 COSMIC
COSN31516863 1052 COSMIC
COSN31571797 1064 COSMIC
COSN30160487 1074 COSMIC
COSN30164390 1085 COSMIC
COSN28690816 1093 COSMIC
COSN27801214 1569 COSMIC
COSN27232482 1742 COSMIC
COSN31596282 1742 COSMIC
COSN31551686 1745 COSMIC
COSN31535468 1758 COSMIC
COSN31529594 1762 COSMIC
COSN31550309 1809 COSMIC
COSN8637370 1905 COSMIC
COSN31580004 1964 COSMIC
COSN31579654 1981 COSMIC
COSN31540488 1985 COSMIC
COSN28024703 2028 COSMIC
COSN22726057 2051 COSMIC
COSN31530166 2103 COSMIC
COSN28738463 2120 COSMIC
COSN19213080 2225 COSMIC
COSN31488624 2370 COSMIC
COSN28646258 2374 COSMIC
COSN31539132 2700 COSMIC
COSN24297688 2701 COSMIC
COSN26563484 2722 COSMIC
COSN26551695 2779 COSMIC
COSN31530165 2786 COSMIC
COSN20770187 2801 COSMIC
COSN8637371 2822 COSMIC
COSN26635663 2868 COSMIC
COSN31489892 2891 COSMIC
COSN31513703 3015 COSMIC
rs12117082 233 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs782145439 2 dbSNP
rs782706078 7 dbSNP
rs781788927 10 dbSNP
rs1338786905 11 dbSNP
rs782098352 33 dbSNP
rs560685633 37 dbSNP
rs1383017567 42 dbSNP
rs999097015 46 dbSNP
rs368241244 50 dbSNP
rs529733130 54 dbSNP
rs1455432349 63 dbSNP
rs1411236059 65 dbSNP
rs868938568 67 dbSNP
rs1473704563 73 dbSNP
rs782259716 77 dbSNP
rs1186174796 82 dbSNP
rs12135281 89 dbSNP
rs562905511 90 dbSNP
rs952789611 91 dbSNP
rs1207296635 97 dbSNP
rs1328904024 101 dbSNP
rs1274130536 102 dbSNP
rs1230547285 118 dbSNP
rs1354810478 132 dbSNP
rs984124125 136 dbSNP
rs1228216734 141 dbSNP
rs1367693134 160 dbSNP
rs1318778545 163 dbSNP
rs782023312 169 dbSNP
rs542408016 171 dbSNP
rs532035186 172 dbSNP
rs1323916499 183 dbSNP
rs1407045613 188 dbSNP
rs1411495120 194 dbSNP
rs1162184605 197 dbSNP
rs1449535227 204 dbSNP
rs1391706765 207 dbSNP
rs1186289501 208 dbSNP
rs1464121969 209 dbSNP
rs939912515 211 dbSNP
rs1224192971 212 dbSNP
rs1450440630 224 dbSNP
rs976697405 226 dbSNP
rs1215308704 229 dbSNP
rs12117082 233 dbSNP
rs571959326 234 dbSNP
rs1227972984 238 dbSNP
rs531460977 239 dbSNP
rs377702788 243 dbSNP
rs1438322277 252 dbSNP
rs946506089 255 dbSNP
rs1042026291 258 dbSNP
rs1430258829 259 dbSNP
rs1166126184 266 dbSNP
rs781973271 268 dbSNP
rs1425401922 276 dbSNP
rs759838507 279 dbSNP
rs782085538 283 dbSNP
rs1477241885 285 dbSNP
rs1246420196 292 dbSNP
rs547788069 294 dbSNP
rs567780448 297 dbSNP
rs1204485820 301 dbSNP
rs999044774 308 dbSNP
rs1280986138 311 dbSNP
rs1220807539 313 dbSNP
rs1365235175 318 dbSNP
rs782780117 325 dbSNP
rs1035921238 331 dbSNP
rs895942754 334 dbSNP
rs1352220813 335 dbSNP
rs1013094204 338 dbSNP
rs781862229 341 dbSNP
rs138294302 342 dbSNP
rs545087400 346 dbSNP
rs556331091 350 dbSNP
rs1424931217 374 dbSNP
rs1183299233 378 dbSNP
rs1015592738 383 dbSNP
rs193161073 388 dbSNP
rs1250222735 411 dbSNP
rs1181626072 414 dbSNP
rs1483619276 416 dbSNP
rs1257771398 421 dbSNP
rs1311780983 426 dbSNP
rs1262317645 429 dbSNP
rs976643431 432 dbSNP
rs1228753899 436 dbSNP
rs1286371777 440 dbSNP
rs922559041 440 dbSNP
rs1409066683 445 dbSNP
rs76370628 445 dbSNP
rs1379280917 448 dbSNP
rs1304028661 449 dbSNP
rs1445400233 449 dbSNP
rs932436074 458 dbSNP
rs1459146407 459 dbSNP
rs985305752 459 dbSNP
rs915090653 461 dbSNP
rs1159082767 464 dbSNP
rs1180156719 464 dbSNP
rs1258383234 464 dbSNP
rs1410489131 464 dbSNP
rs1424850926 464 dbSNP
rs1483073157 464 dbSNP
rs74693698 464 dbSNP
rs1248864393 465 dbSNP
rs1209193417 466 dbSNP
rs1466090402 471 dbSNP
rs1265943295 472 dbSNP
rs1238271098 473 dbSNP
rs1322211060 476 dbSNP
rs1314299780 478 dbSNP
rs141152170 480 dbSNP
rs1204297982 481 dbSNP
rs1226095433 481 dbSNP
rs1245995697 481 dbSNP
rs1267133048 481 dbSNP
rs1291750452 481 dbSNP
rs1321951392 481 dbSNP
rs1390787886 481 dbSNP
rs1463673392 481 dbSNP
rs1488794609 481 dbSNP
rs3833477 481 dbSNP
rs71967509 481 dbSNP
rs782436874 481 dbSNP
rs75583061 488 dbSNP
rs1358116382 489 dbSNP
rs782363225 489 dbSNP
rs946455505 490 dbSNP
rs72288040 493 dbSNP
rs144021959 495 dbSNP
rs1297623908 498 dbSNP
rs1230193408 499 dbSNP
rs72087299 500 dbSNP
rs1295369269 503 dbSNP
rs1387691198 505 dbSNP
rs1393596117 505 dbSNP
rs1292291459 506 dbSNP
rs1457792617 507 dbSNP
rs1491063452 509 dbSNP
rs781956212 509 dbSNP
rs1042143488 510 dbSNP
rs57941881 510 dbSNP
rs538826931 511 dbSNP
rs558464445 513 dbSNP
rs1057496407 521 dbSNP
rs1192277472 522 dbSNP
rs1433554189 527 dbSNP
rs185610226 532 dbSNP
rs1013625555 533 dbSNP
rs7549189 535 dbSNP
rs1490152876 560 dbSNP
rs1274780789 562 dbSNP
rs527665149 578 dbSNP
rs1206647068 579 dbSNP
rs1339701726 593 dbSNP
rs888648263 618 dbSNP
rs2990590 620 dbSNP
rs1299579552 625 dbSNP
rs1015707219 633 dbSNP
rs1404913160 634 dbSNP
rs961341077 644 dbSNP
rs1351607508 654 dbSNP
rs149190515 674 dbSNP
rs80104336 676 dbSNP
rs1396132278 677 dbSNP
rs1173383531 682 dbSNP
rs1467724937 686 dbSNP
rs571030457 687 dbSNP
rs531851242 688 dbSNP
rs34714974 700 dbSNP
rs1480094485 703 dbSNP
rs545601260 704 dbSNP
rs115275274 707 dbSNP
rs1249136917 711 dbSNP
rs1200696890 716 dbSNP
rs967873244 728 dbSNP
rs1346631729 738 dbSNP
rs1254668959 743 dbSNP
rs758892563 747 dbSNP
rs1330498484 756 dbSNP
rs923699655 760 dbSNP
rs1408468637 763 dbSNP
rs938981972 767 dbSNP
rs1056131440 795 dbSNP
rs1334864774 798 dbSNP
rs1398041126 799 dbSNP
rs374486529 801 dbSNP
rs1400301678 807 dbSNP
rs916266466 808 dbSNP
rs11576488 810 dbSNP
rs1045068456 811 dbSNP
rs888594682 812 dbSNP
rs1161297136 824 dbSNP
rs1005738399 848 dbSNP
rs1037086625 850 dbSNP
rs897239601 851 dbSNP
rs1471539298 860 dbSNP
rs998709015 861 dbSNP
rs1029649982 868 dbSNP
rs1362739399 869 dbSNP
rs1187600074 875 dbSNP
rs782291636 885 dbSNP
rs1443835547 888 dbSNP
rs1253628617 905 dbSNP
rs954209239 909 dbSNP
rs1203506465 912 dbSNP
rs1465635832 914 dbSNP
rs547826147 915 dbSNP
rs1270351948 920 dbSNP
rs1227118063 923 dbSNP
rs1006783504 929 dbSNP
rs1350544170 937 dbSNP
rs1022646564 939 dbSNP
rs868978426 944 dbSNP
rs1338990903 945 dbSNP
rs77974377 946 dbSNP
rs1436012436 949 dbSNP
rs1389130438 957 dbSNP
rs1322250683 970 dbSNP
rs143093460 971 dbSNP
rs960437499 979 dbSNP
rs1163393562 983 dbSNP
rs138854464 984 dbSNP
rs199525406 993 dbSNP
rs1473491159 996 dbSNP
rs1382783044 1008 dbSNP
rs782403191 1015 dbSNP
rs1182613404 1033 dbSNP
rs550056594 1038 dbSNP
rs916232359 1047 dbSNP
rs757654634 1056 dbSNP
rs189072901 1059 dbSNP
rs1044625785 1066 dbSNP
rs1446985819 1078 dbSNP
rs1291205970 1084 dbSNP
rs1212080392 1095 dbSNP
rs1354346407 1102 dbSNP
rs1314406821 1113 dbSNP
rs1229448710 1117 dbSNP
rs1367578257 1124 dbSNP
rs113920539 1129 dbSNP
rs941630243 1132 dbSNP
rs1324133092 1141 dbSNP
rs1406962633 1148 dbSNP
rs538492848 1150 dbSNP
rs781924979 1156 dbSNP
rs782234615 1169 dbSNP
rs1430049980 1176 dbSNP
rs782344262 1177 dbSNP
rs138578605 1183 dbSNP
rs889763959 1185 dbSNP
rs1007310602 1188 dbSNP
rs1247593395 1198 dbSNP
rs1201671111 1199 dbSNP
rs181419790 1205 dbSNP
rs1291180575 1206 dbSNP
rs1205929237 1208 dbSNP
rs1344651795 1211 dbSNP
rs1272747023 1214 dbSNP
rs1214136425 1228 dbSNP
rs1361028795 1265 dbSNP
rs903777992 1268 dbSNP
rs1343534617 1269 dbSNP
rs1302044670 1298 dbSNP
rs999433106 1301 dbSNP
rs1030780554 1304 dbSNP
rs550354436 1305 dbSNP
rs991901456 1308 dbSNP
rs1174643290 1330 dbSNP
rs1023819551 1334 dbSNP
rs1268781344 1343 dbSNP
rs969049250 1346 dbSNP
rs1484079785 1347 dbSNP
rs1231188989 1349 dbSNP
rs1204121152 1354 dbSNP
rs1312955674 1358 dbSNP
rs1279117932 1359 dbSNP
rs1220719836 1360 dbSNP
rs745309705 1362 dbSNP
rs1282560699 1367 dbSNP
rs1410293063 1389 dbSNP
rs1351817815 1392 dbSNP
rs141601592 1422 dbSNP
rs570376374 1431 dbSNP
rs1441074712 1437 dbSNP
rs1359355985 1439 dbSNP
rs941577802 1440 dbSNP
rs1336620876 1441 dbSNP
rs1468560728 1442 dbSNP
rs146189267 1443 dbSNP
rs574396479 1455 dbSNP
rs918734304 1457 dbSNP
rs1176662403 1459 dbSNP
rs1483730982 1464 dbSNP
rs113572428 1468 dbSNP
rs1051153437 1473 dbSNP
rs1205405919 1478 dbSNP
rs1459820887 1480 dbSNP
rs1262489376 1482 dbSNP
rs1228749780 1484 dbSNP
rs1318538702 1494 dbSNP
rs1304356352 1498 dbSNP
rs1222866406 1503 dbSNP
rs889870522 1509 dbSNP
rs942839437 1517 dbSNP
rs1043700853 1527 dbSNP
rs1285445173 1529 dbSNP
rs1405964894 1535 dbSNP
rs1449905816 1535 dbSNP
rs1321851948 1536 dbSNP
rs1459116955 1540 dbSNP
rs782814401 1543 dbSNP
rs1343822950 1549 dbSNP
rs1158579026 1550 dbSNP
rs1424616692 1551 dbSNP
rs1416307349 1564 dbSNP
rs1181809908 1569 dbSNP
rs1444133388 1570 dbSNP
rs1242414158 1574 dbSNP
rs1209306057 1579 dbSNP
rs1486692415 1601 dbSNP
rs1258745897 1606 dbSNP
rs1214892783 1607 dbSNP
rs184072346 1608 dbSNP
rs1316773877 1609 dbSNP
rs1243096519 1614 dbSNP
rs1381442564 1619 dbSNP
rs1298922112 1622 dbSNP
rs1437916182 1623 dbSNP
rs1360223648 1627 dbSNP
rs903894003 1638 dbSNP
rs1288647452 1657 dbSNP
rs1458784911 1659 dbSNP
rs769496897 1660 dbSNP
rs1351807176 1664 dbSNP
rs576849767 1665 dbSNP
rs1424046375 1681 dbSNP
rs1030897138 1683 dbSNP
rs1390882981 1690 dbSNP
rs782066926 1691 dbSNP
rs1430235633 1693 dbSNP
rs1259645709 1694 dbSNP
rs1185692803 1712 dbSNP
rs1488707816 1714 dbSNP
rs1293442833 1718 dbSNP
rs1219824414 1720 dbSNP
rs113290370 1726 dbSNP
rs1358030534 1726 dbSNP
rs1295553393 1729 dbSNP
rs1389664327 1729 dbSNP
rs3841378 1729 dbSNP
rs587686551 1729 dbSNP
rs77995616 1729 dbSNP
rs76696396 1731 dbSNP
rs1387671899 1732 dbSNP
rs1347807986 1742 dbSNP
rs1301464600 1744 dbSNP
rs1404575196 1749 dbSNP
rs536129517 1750 dbSNP
rs1460573544 1756 dbSNP
rs1371236534 1765 dbSNP
rs969534416 1766 dbSNP
rs984565590 1767 dbSNP
rs1015918242 1776 dbSNP
rs1433502415 1783 dbSNP
rs1270794276 1794 dbSNP
rs1196749536 1808 dbSNP
rs1490082283 1810 dbSNP
rs961722776 1825 dbSNP
rs1252160087 1830 dbSNP
rs1197007038 1834 dbSNP
rs1336921673 1836 dbSNP
rs972950794 1842 dbSNP
rs1234625455 1844 dbSNP
rs551114314 1860 dbSNP
rs1281768404 1862 dbSNP
rs1223342531 1867 dbSNP
rs1351317208 1868 dbSNP
rs1331176309 1871 dbSNP
rs56953768 1887 dbSNP
rs572783087 1889 dbSNP
rs541696655 1904 dbSNP
rs1466491634 1925 dbSNP
rs1431438910 1929 dbSNP
rs1173967774 1947 dbSNP
rs1480013454 1949 dbSNP
rs1412205729 1950 dbSNP
rs779627181 1952 dbSNP
rs9430148 1956 dbSNP
rs1249217773 1959 dbSNP
rs1043815783 1960 dbSNP
rs188366783 1963 dbSNP
rs1261869043 1964 dbSNP
rs1203400669 1973 dbSNP
rs1330280299 1986 dbSNP
rs181265678 1987 dbSNP
rs1281440145 1990 dbSNP
rs925264669 1991 dbSNP
rs1335176572 2002 dbSNP
rs1313523543 2003 dbSNP
rs1454700240 2007 dbSNP
rs1408175398 2009 dbSNP
rs782074770 2012 dbSNP
rs563661249 2023 dbSNP
rs1469059763 2024 dbSNP
rs1385425984 2026 dbSNP
rs533543510 2036 dbSNP
rs1468280979 2043 dbSNP
rs1052271936 2046 dbSNP
rs1362923561 2052 dbSNP
rs1187616666 2055 dbSNP
rs896398824 2058 dbSNP
rs1445971378 2061 dbSNP
rs1241795296 2068 dbSNP
rs117543517 2069 dbSNP
rs551970065 2074 dbSNP
rs1203610263 2095 dbSNP
rs782762161 2098 dbSNP
rs1465583340 2099 dbSNP
rs1286784974 2100 dbSNP
rs565497983 2107 dbSNP
rs1203823165 2110 dbSNP
rs1350208482 2113 dbSNP
rs534607225 2116 dbSNP
rs3813981 2120 dbSNP
rs782547529 2139 dbSNP
rs1380708319 2142 dbSNP
rs1312764020 2149 dbSNP
rs1451832993 2151 dbSNP
rs1327024998 2152 dbSNP
rs782590374 2157 dbSNP
rs961670426 2159 dbSNP
rs993166097 2160 dbSNP
rs1383754778 2175 dbSNP
rs116102505 2178 dbSNP
rs536674616 2180 dbSNP
rs774112581 2186 dbSNP
rs1476024047 2192 dbSNP
rs556887299 2193 dbSNP
rs1191455189 2207 dbSNP
rs1446822578 2214 dbSNP
rs1268264139 2224 dbSNP
rs782486643 2225 dbSNP
rs979458665 2226 dbSNP
rs573352083 2227 dbSNP
rs1229307630 2229 dbSNP
rs1339969418 2245 dbSNP
rs1271900011 2249 dbSNP
rs935297445 2250 dbSNP
rs1325663112 2256 dbSNP
rs1303319728 2266 dbSNP
rs1052386081 2267 dbSNP
rs1363401614 2276 dbSNP
rs917951211 2280 dbSNP
rs1162360476 2282 dbSNP
rs949307301 2285 dbSNP
rs1410087707 2286 dbSNP
rs1422229878 2296 dbSNP
rs576879382 2313 dbSNP
rs1475259624 2320 dbSNP
rs904994221 2324 dbSNP
rs1430439333 2325 dbSNP
rs1202133819 2326 dbSNP
rs1006065670 2331 dbSNP
rs539497345 2336 dbSNP
rs559196233 2342 dbSNP
rs1205922397 2343 dbSNP
rs1274969934 2344 dbSNP
rs897575864 2349 dbSNP
rs782617520 2359 dbSNP
rs186135736 2360 dbSNP
rs1225176445 2362 dbSNP
rs541636640 2364 dbSNP
rs954425763 2368 dbSNP
rs1355792081 2374 dbSNP
rs3813980 2374 dbSNP
rs782380424 2380 dbSNP
rs1409896448 2381 dbSNP
rs1430688614 2391 dbSNP
rs1179008278 2393 dbSNP
rs1479685186 2395 dbSNP
rs1428813879 2404 dbSNP
rs1178020087 2406 dbSNP
rs1471167859 2408 dbSNP
rs1231254533 2413 dbSNP
rs1203998951 2420 dbSNP
rs1263730972 2421 dbSNP
rs1457251721 2421 dbSNP
rs964148179 2435 dbSNP
rs782677613 2437 dbSNP
rs1224000877 2444 dbSNP
rs771868510 2458 dbSNP
rs1375164154 2459 dbSNP
rs1032514492 2463 dbSNP
rs190943052 2465 dbSNP
rs1440903754 2468 dbSNP
rs1407440443 2493 dbSNP
rs782284580 2501 dbSNP
rs543476049 2502 dbSNP
rs1402661032 2507 dbSNP
rs1406131399 2510 dbSNP
rs917884901 2514 dbSNP
rs949424167 2528 dbSNP
rs1445356241 2532 dbSNP
rs782323117 2537 dbSNP
rs563667045 2540 dbSNP
rs1459765347 2544 dbSNP
rs1255192784 2548 dbSNP
rs1216310953 2562 dbSNP
rs1318333661 2569 dbSNP
rs1281760530 2589 dbSNP
rs782117779 2590 dbSNP
rs1382915906 2591 dbSNP
rs1317710288 2605 dbSNP
rs1451103770 2606 dbSNP
rs1289800992 2611 dbSNP
rs1455718943 2615 dbSNP
rs782786988 2626 dbSNP
rs532480088 2629 dbSNP
rs897690556 2632 dbSNP
rs9242 2636 dbSNP
rs116040527 2640 dbSNP
rs1165315383 2641 dbSNP
rs890090622 2645 dbSNP
rs1007236539 2651 dbSNP
rs1186861234 2653 dbSNP
rs1486743807 2655 dbSNP
rs528304079 2700 dbSNP
rs1018905301 2701 dbSNP
rs1215465518 2708 dbSNP
rs1293313517 2709 dbSNP
rs1243213843 2713 dbSNP
rs1321619931 2717 dbSNP
rs1296970279 2719 dbSNP
rs1384231833 2720 dbSNP
rs1360335812 2724 dbSNP
rs548343071 2725 dbSNP
rs1001109613 2730 dbSNP
rs1367756096 2732 dbSNP
rs1301348341 2740 dbSNP
rs1424146313 2746 dbSNP
rs568285450 2747 dbSNP
rs1171087607 2753 dbSNP
rs1430022532 2754 dbSNP
rs530797469 2760 dbSNP
rs1192756894 2765 dbSNP
rs1490407260 2774 dbSNP
rs1270655426 2775 dbSNP
rs1219581550 2778 dbSNP
rs1487890862 2780 dbSNP
rs1252351258 2798 dbSNP
rs1230273933 2803 dbSNP
rs1306057931 2820 dbSNP
rs1277954494 2824 dbSNP
rs557705808 2827 dbSNP
rs1347590962 2829 dbSNP
rs1301562007 2835 dbSNP
rs182251209 2836 dbSNP
rs1397321185 2837 dbSNP
rs1298612953 2846 dbSNP
rs1025064842 2848 dbSNP
rs1463459545 2849 dbSNP
rs1352749271 2865 dbSNP
rs545313917 2869 dbSNP
rs1480663443 2870 dbSNP
rs1430922707 2871 dbSNP
rs1196860193 2873 dbSNP
rs1432029103 2874 dbSNP
rs1250616312 2876 dbSNP
rs539435058 2886 dbSNP
rs1479933029 2891 dbSNP
rs1204672055 2896 dbSNP
rs1326135352 2906 dbSNP
rs1232815681 2908 dbSNP
rs553146767 2909 dbSNP
rs1309222852 2912 dbSNP
rs1389795353 2925 dbSNP
rs1374529758 2933 dbSNP
rs1330627633 2944 dbSNP
rs1408042285 2945 dbSNP
rs797026757 2945 dbSNP
rs1173726327 2953 dbSNP
rs926644171 2973 dbSNP
rs1364071897 2988 dbSNP
rs1183315826 2990 dbSNP
rs1416825973 2993 dbSNP
rs1238054103 2995 dbSNP
rs566560758 3003 dbSNP
rs941913815 3015 dbSNP
rs1462881981 3016 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cacacgagaGACC-AGUugguag 5'
                   |||| |||      
Target 5' gaagaguggCUGGCUCAc----- 3'
2 - 19
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000383836.3 | 3UTR | AGAAGAGUGGCUGGCUCAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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