pre-miRNA Information | |
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pre-miRNA | hsa-mir-758 |
Genomic Coordinates | chr14: 101026020 - 101026107 |
Synonyms | MIRN758, hsa-mir-758, MIR758 |
Description | Homo sapiens miR-758 stem-loop |
Comment | None |
RNA Secondary Structure | ![]() |
Associated Diseases | ![]() |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-758-5p | |||||||||||||||||||||||||||||||||||||||||||||
Sequence | 15| GAUGGUUGACCAGAGAGCACAC |36 | |||||||||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||||||||||||||
Experiments | SOLiD | |||||||||||||||||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SRGAP2 | ||||||||||||||||||||
Synonyms | ARHGAP34, FNBP2, SRGAP2A, SRGAP3 | ||||||||||||||||||||
Description | SLIT-ROBO Rho GTPase activating protein 2 | ||||||||||||||||||||
Transcript | NM_001170637 | ||||||||||||||||||||
Other Transcripts | NM_015326 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SRGAP2 | |||||||||||||||||||||
3'UTR of SRGAP2 (miRNA target sites are highlighted) |
>SRGAP2|NM_001170637|3'UTR 1 GGGATAATAATTTAATTGTTCTAGACAAGGGGACTATAGGGACTGACTGTTATTAAAATCTTCCTATTTAACTAGCTTGG 81 GGACTTCAGTTGAAAATTAGGTTCTAAGTTGTTCTTGCAGGAATTAGCCTCCCCGTCTCCCAAAACCTTGAGAATGAAGC 161 CCTTGGTATCGCCTCTCCCTTCCCACTGCCCTCTGCTTCCCCCAGTCGTCGTAATTCAGCCAGCTGCAGTCCGTACCGTT 241 CTTAGGTTAGCCAGAGACAGGTTTTCATTATCAGGTCACTGTGAAATCTGGTAAGGCAGTCCTGAGGACATGGGCTCAAG 321 TCTCAGTCCCCTCAGACCACGGTGATGCCTTGACCAGATGGTTGGCTACTGCCATCCAGCTTTCAGTGGCATCTTGTTTT 401 GGGAACTGATTATAGAGAATCATATATAGTCCAGTCTTCATTTTACATACACACACATATTTTACACACACACACATTTT 481 ACACACACACACACACACACACACACACATATGTTTTTCTAGTCTCTGGCATGTGTAGCCTCTCCTGGTCATAGACCAGT 561 CTCTTTGTAAGTTATTGTGGCAGTTCACACAGTAGCCACCAGGGGTCTCTGTTTCCATCACAAACTTTGTTCTGTCTGGG 641 CCAGAGAACCTAGCCTTTGAAATCTCTCCATCATATGAAACATAACGGGATGGGACAATCCCGTAACCTGTTTGGGGTTG 721 GGGGCTTTCTCTCTGTGTTCTTTCCATTGATGTGAATTGGTCATTGGTGTTTGCTCTTGCCTCTCCTCCATCCCCTAGAA 801 GTACACCCCCGTCTTATTAAGGAGCTTTTAAAGTTTTTCTGAATGTATAGACATTTCTCGGGTTCCTACCTTTGTCTCTG 881 ATGGACCATTTTCCATTTAAGACATTTTCCTGTATAAGACAGTTTTATAGCTGGTTCCTTTTAGGGTAAAGAGTCTTAAG 961 AGAGTTTTATTGTGTCTATGGCAGGTTTGGGAAAGGTAAGAAATGGGTCCTTTTTCCTCCTAATGTTTTTGGCACTTAAA 1041 ACATAAAATTCATTATCCTATTAAAAAATTAAATTCAGCTTTGCTAATCCAGAAATTGTTCCCAAATGAAAACTTGTTTT 1121 AAGTCCACCCCTTAGTTTCCTTATTTTACAAGGTCTCTCTTCAGGGACCAACAGGGGCTTAGAGAGCCTTAGTTAGATTA 1201 AAGGGAGACCCTACCTCTTAAAACCAGTTTTCATTTATGCAAACAAGGACAATTAAGGGAACCCTGACCCCACAGGCTCT 1281 CAAGTCTTCCCAAGGCCAGAATCGAAAGAAAATTAAAATTTGAATGCTGAATATTCTGGCTCTACTCTGGCCTTTTTTCT 1361 GGTTCCCTTCCAAAATGCACAAATCATACCCTTGTCTGCTCCAATTCAGTCTCCAAACCTGGTGCCTGTGCTCCTGGCCC 1441 CCCTAGCATCATGCTATCCCAGGAGTATCAGGACCAGACACATCCACAGCCAGGCTCATGGGTCTCAGACAGCAACTTGA 1521 GTTAAAGCTGAAACTCATCCTTCTTCTCTGTGTTTTCTGGTTTAAAAGCTGCACTTATATTTTAGCCTTATTATTTTCTG 1601 TAGTTCCGGAGAGATGGTGGGTTGCCATTCTGGTAGGAAAATCTGAGTTTTCTTATCTTTGACCTAGAAGAGATTCTTTT 1681 TGGACCAACCTGCGAAATTGGTAGTTAGGTCTATGGAAAGTGGTAGGATTTTTTTTTTTTTAATCCTGTGCAAAGGAAAA 1761 GAGGTGCTTTGTGGGAAATCACTAATGAGAAGGCTAACCTGCAGCACCAGAGAAACCTTTCCAAGTGCTAGGCAGGAGAA 1841 CTGAAGAACTCTTTCAGTGAAGTGAGTCAGCCTAGAAGAGGCAACCCACAGTCTTGATTTTTGTTGCTGTTTCCTGACCT 1921 GTTCTTGCCTGTCACCTGGGCCTACACAGGTCCCAAGCCAACGGGGCTTTCATACCCAAGGATCTGTTTCCTTGCTGAAA 2001 ATGAAACCCTATCTTTCACTTTACATTCCTTTCAATCCAACTGATCAAAACTGGTACCCACACTTGCCCTTTCTCCCTCT 2081 CTCCAGCACACTCCCCTCTAAGAAAGTAAAAGCAAAGCTTTCTTAATGGCAACACTTTGGGCCTGTTCTGTTGCTCCTGC 2161 CTTATTTCTCTTTCAACCCTGTACATGACTCGTGTTCACCATCCCCTTGATCAGTGTCCATCCGCGCTAATTTGCATCAT 2241 GAACTGAACAGTGTGTGAGTGGTCACCTACTAAACCCAGCTCTGGGGGCAGAGCTGTCTTCCCCATCTCTGGTGCTCCTA 2321 ACACCTGTGAGATGGTCCTGTCGAGAGGACTAGGAACCGATAGGAGGAGAGTCCTTCTCGGCAGAGCTCACTGCAAACAA 2401 CTGGAATTGAGGTTGCACACTGTGATTTTTACACCGAAAAGCCAAAAGGAGCTGGCCATCCAGGGCCTAGGGAGACCAGC 2481 CTTCCTCAGCTATGCTTGCCGAAACCAGCATGATGCTTCAAAGAGCCCTGCTCCACCCCTCATGGCATGGATCCTTTTCC 2561 TGGTGTGGACTCTGAAGGGTCAGTCTTCGGGGAAGAGAGGTGGGGTGGGGCTACTAGCATCCCAATTTAGAAAATAGAGG 2641 AGTTTGTAGCCAGCAGCCTGTAAACTGGAAACACTGGTCTCAGCCAACCTCCTCAGGGCGCCCTGGCTTCTCCCCAAGGA 2721 GATGAGGAGCGGTGATGCCAGCACCGGGATGCGCAGAGCACTGGAAGGGCTGGTGCAGATCTACTTCCCATGCAGAAGAG 2801 AAGTCACATCTTCCAGGGAATCGCAATGTTGTGGCGTCTGACTTGTATGTCACATTTGTGTAAAATGGTATATTCTTTAA 2881 AATAGTGTTGATAACTGGAATATTGTATGTATGCTTGGAGATGCTTTGTGTGAACCTAAGACTGTCACTCAACAGATGTT 2961 GGATTGGGGAAAATCCAAAGCACAACTTCAAAATAAAATACATTTTTAGGTTTCGATGCTGCAAAAAAAAAAAAAAAAAA 3041 AAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293S | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb
... - Karginov FV; Hannon GJ, 2013, Genes & development. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Karginov FV; Hannon GJ - Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
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CLIP-seq Support 1 for dataset GSM1084067 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293S / CLIP_emetine_SantaCruzAb |
Location of target site | ENST00000383836.3 | 3UTR | AGAAGAGUGGCUGGCUCAC |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23824327 / GSE44404 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT085323 | MORC3 | MORC family CW-type zinc finger 3 | ![]() |
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2 | 2 | ||||||
MIRT089441 | STAMBP | STAM binding protein | ![]() |
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2 | 2 | ||||||
MIRT089456 | TET3 | tet methylcytosine dioxygenase 3 | ![]() |
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2 | 2 | ||||||
MIRT111856 | CCND1 | cyclin D1 | ![]() |
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2 | 2 | ||||||
MIRT184933 | ZNF268 | zinc finger protein 268 | ![]() |
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2 | 2 | ||||||
MIRT215288 | CREBRF | CREB3 regulatory factor | ![]() |
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2 | 2 | ||||||
MIRT237300 | LPP | LIM domain containing preferred translocation partner in lipoma | ![]() |
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2 | 2 | ||||||
MIRT238446 | MYO10 | myosin X | ![]() |
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2 | 4 | ||||||
MIRT273827 | RPL41 | ribosomal protein L41 | ![]() |
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2 | 2 | ||||||
MIRT282703 | HOOK1 | hook microtubule tethering protein 1 | ![]() |
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2 | 2 | ||||||
MIRT347970 | ZNF850 | zinc finger protein 850 | ![]() |
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2 | 2 | ||||||
MIRT371076 | KLF3 | Kruppel like factor 3 | ![]() |
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2 | 2 | ||||||
MIRT464339 | USP6NL | USP6 N-terminal like | ![]() |
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2 | 2 | ||||||
MIRT470034 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | ![]() |
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2 | 2 | ||||||
MIRT477506 | ELL2 | elongation factor for RNA polymerase II 2 | ![]() |
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2 | 2 | ||||||
MIRT482886 | CACNA2D3 | calcium voltage-gated channel auxiliary subunit alpha2delta 3 | ![]() |
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2 | 2 | ||||||
MIRT492606 | POLR3E | RNA polymerase III subunit E | ![]() |
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2 | 2 | ||||||
MIRT502294 | GNG12 | G protein subunit gamma 12 | ![]() |
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2 | 6 | ||||||
MIRT507600 | DCTN4 | dynactin subunit 4 | ![]() |
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2 | 4 | ||||||
MIRT510728 | SON | SON DNA binding protein | ![]() |
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2 | 6 | ||||||
MIRT514065 | KCNJ6 | potassium voltage-gated channel subfamily J member 6 | ![]() |
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2 | 8 | ||||||
MIRT519718 | ZNF512B | zinc finger protein 512B | ![]() |
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2 | 4 | ||||||
MIRT520890 | STRN | striatin | ![]() |
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2 | 2 | ||||||
MIRT521760 | PPIL1 | peptidylprolyl isomerase like 1 | ![]() |
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2 | 6 | ||||||
MIRT526874 | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit | ![]() |
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2 | 2 | ||||||
MIRT530232 | WSB2 | WD repeat and SOCS box containing 2 | ![]() |
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2 | 2 | ||||||
MIRT532003 | ACTR2 | ARP2 actin related protein 2 homolog | ![]() |
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2 | 2 | ||||||
MIRT533371 | UBE2D4 | ubiquitin conjugating enzyme E2 D4 (putative) | ![]() |
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2 | 4 | ||||||
MIRT547106 | PIGW | phosphatidylinositol glycan anchor biosynthesis class W | ![]() |
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2 | 2 | ||||||
MIRT548189 | FOXA1 | forkhead box A1 | ![]() |
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2 | 2 | ||||||
MIRT552935 | VKORC1L1 | vitamin K epoxide reductase complex subunit 1 like 1 | ![]() |
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2 | 2 | ||||||
MIRT560085 | ZNF195 | zinc finger protein 195 | ![]() |
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2 | 2 | ||||||
MIRT561726 | PPP2CA | protein phosphatase 2 catalytic subunit alpha | ![]() |
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2 | 2 | ||||||
MIRT562713 | ZNF415 | zinc finger protein 415 | ![]() |
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2 | 2 | ||||||
MIRT562761 | ZNF846 | zinc finger protein 846 | ![]() |
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2 | 2 | ||||||
MIRT564159 | ZNF117 | zinc finger protein 117 | ![]() |
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2 | 2 | ||||||
MIRT565673 | SETD5 | SET domain containing 5 | ![]() |
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2 | 2 | ||||||
MIRT565718 | SESN3 | sestrin 3 | ![]() |
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2 | 2 | ||||||
MIRT566026 | RFX1 | regulatory factor X1 | ![]() |
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2 | 2 | ||||||
MIRT569048 | ZNF655 | zinc finger protein 655 | ![]() |
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2 | 2 | ||||||
MIRT570367 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | ![]() |
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2 | 2 | ||||||
MIRT570410 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | ![]() |
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2 | 2 | ||||||
MIRT570443 | TMEM189 | transmembrane protein 189 | ![]() |
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2 | 2 | ||||||
MIRT571738 | RNF11 | ring finger protein 11 | ![]() |
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2 | 2 | ||||||
MIRT575042 | Tpgs2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 4 | ||||||
MIRT614330 | ZDHHC22 | zinc finger DHHC-type containing 22 | ![]() |
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2 | 2 | ||||||
MIRT617629 | RAB3IP | RAB3A interacting protein | ![]() |
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2 | 2 | ||||||
MIRT621667 | UBE4B | ubiquitination factor E4B | ![]() |
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2 | 2 | ||||||
MIRT639906 | SRGAP2 | SLIT-ROBO Rho GTPase activating protein 2 | ![]() |
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2 | 2 | ||||||
MIRT651436 | XRCC5 | X-ray repair cross complementing 5 | ![]() |
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2 | 2 | ||||||
MIRT683853 | ZNF208 | zinc finger protein 208 | ![]() |
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2 | 2 | ||||||
MIRT684841 | TPGS2 | tubulin polyglutamylase complex subunit 2 | ![]() |
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2 | 5 | ||||||
MIRT689347 | ZNF83 | zinc finger protein 83 | ![]() |
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2 | 2 | ||||||
MIRT692492 | SPIN4 | spindlin family member 4 | ![]() |
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2 | 2 | ||||||
MIRT695711 | OLA1 | Obg like ATPase 1 | ![]() |
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2 | 2 | ||||||
MIRT698219 | TMEM248 | transmembrane protein 248 | ![]() |
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2 | 2 | ||||||
MIRT711560 | FAM20B | FAM20B, glycosaminoglycan xylosylkinase | ![]() |
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2 | 2 | ||||||
MIRT712867 | TMEM67 | transmembrane protein 67 | ![]() |
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2 | 2 | ||||||
MIRT722956 | TSPAN1 | tetraspanin 1 | ![]() |
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2 | 2 | ||||||
MIRT723622 | SOBP | sine oculis binding protein homolog | ![]() |
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2 | 2 | ||||||
MIRT724176 | ABCF2 | ATP binding cassette subfamily F member 2 | ![]() |
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2 | 2 | ||||||
MIRT755363 | LMBR1 | limb development membrane protein 1 | 3 | 1 |
miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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