pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol PHF21B   
Synonyms BHC80L, PHF4
Description PHD finger protein 21B
Transcript NM_001135862   
Other Transcripts NM_138415   
Expression
Putative miRNA Targets on PHF21B
3'UTR of PHF21B
(miRNA target sites are highlighted)
>PHF21B|NM_001135862|3'UTR
   1 CCCCGAGGGACCAGTCTTCATACCCACGGAAAGTTATTGGGACCCTGCTTACACAGCCTGGGGGTTCTGTCGGCCTTAAT
  81 TCATAAACACTATGAATTTCAGACAAAAATTAACCAGACAGAGGAGAGGAGGGAGGAAGAGCTGGGCGAGAGGCCTAGAG
 161 CCAGGACCAGGTGGGGGTGCGGCCCTGTGCCCTCCAAATTCACAGGGGGTACCTAGGAGCCAGGTGGGGTACGACAGGCT
 241 GGGGCACACAGTCTCCCCCCGGCCACCTCGGGGCTGCCTGGGCCTCTGGCTTCCAGGCCCTGCTCTCCACGGCCTCCCTC
 321 TGGCCCGTTGGAGGGGCAGGCTGAGGCTGTGGAGGGGACAAGCACGCCCCCCAGAACGCAGTCTCCACTGAGGGCACCGC
 401 CTATTGGTGTCCTGTGGGAGGGCGAGCTGAGAACACATGGACTAGCTGAGTGGTAGCGGTAGTTGGGACGAGAAGCGGGG
 481 TAGTGGATCTAGGTAGTTCCTCAATGCCCCACGCTCCTAGGAGGTCCCCCTGGGGTGGGCGGGCGGGCCTGGGGCACTCC
 561 GTCGCCTTTGCAGAACCACCTGGGCCCCTTTCTGTCAGTATTATTAGGGTTACGAATTGCAGCTGTTTAACTTGAAAGAC
 641 ACTGTCGGAGGTGAGCATCTGGGCGCCGGGACGCTGCAGTGATCCCCGCCAGAGCCTGTGCCCTTCCTGCTCCGTCTTTG
 721 GGGTCCTCAAGGCTGCCTCCTTCCTTTTGCCAATCTCTTGGACTCAGTTTGCCGTTGATGCGTTTTTCTCATGGAGTTTC
 801 TGGGCAGAGTGGAGCTGCAACCCTGTTGTGGGGGGCAGCATTTGGCAGGTTTTCTCCTTGGGGTTGAATCATTCAACTTA
 881 ACGACTGAAGCCCTTTCTTGTCTCCTTTGGAAGAGCCGATAAGTATTCCACTCCTCCCTTCTTGCCAGTGCAGACACTAT
 961 GCCAAAAAATAACTTCACACTTTTGTATGGCGTTTTTATTGTGAGATATTTAATGTGAATGGTTGGGGGGACTCTGGCTG
1041 ACTTCCTTTCTGCTTCTAGTAGTCTCTGCTTCAAGGTACAAATGGGAACACCTCCCCTCGGGAAGCCTGGCCAAGCTGGA
1121 AGATCCGGCAGGTTTTTTACGAGCCGGGTGGAGGGTTGGGGAGGAAAGAAAGGGCGGTGGCTCGGGAGGTTCCGGCCTTC
1201 GGGGACCAGACTTGCTGCCAAGGGCTTCTGCATCCAGGGTGGGCAGTGGCAGCTTGTCACCCTTGCCCGATTCCCACATC
1281 CCAGTCCTGAGGGACTCAGCACAACAGGATAAGCGTCCAGGAGCCACGGGCTCCCACCCCGAGCATATCACATGGTGCCG
1361 AATTGCACTGAACACGCGTGTGTGCATCGCACGCGGCCACGACCACAGACACGCATGCACACACGCAGAGGTGCAGAGCG
1441 AGGAGGCCGGCAAATCCCGCAGCTGCCACGGTCCCTCCTGTCATTCTCACGACTCCGGGAGAAACTGTGCTGTATGATAC
1521 AGATCTATTTTAATACACTTACCACTGGGTGAACAAGATTTTTATATTCTTTTATTGATGAACAAAGTGAACCGTGTGAG
1601 GCACACGTCTTCTATATTGGCTACTCTGTGCCAAGTATGCATTACCGCGTGGCTTGCGATGTCCATGTCTTCAGCTTCCT
1681 TTTCTGTTGGTTTGGTTTTCTTCGCGGATGGATTGAGTTACATGTTTTAACAGTGTAATGGGAGGATCTGAAAGGTTGGA
1761 CCCGGGAGGGGTAGCTGCCGATGTGTCTTGAGATTGTTAGGTTTTTTTTGGACCAAGGAGGACCGTCCAGTGGGTAGTGA
1841 GGATAGAGAAAAAGTGTTTGTCTTAAATACGCCAATGTAGTTTTCCTTCTTTACAATGTATTAAACTCGATCGATGATTT
1921 CAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gauACCCACCCUGUCUCUCCc 5'
             ||||  ||| ||| ||| 
Target 5' ggtTGGGGAGGAAAGAAAGGg 3'
1154 - 1174 134.00 -20.80
2
miRNA  3' gauacCCACCCUGUCUCUCCc 5'
               || | |: ||:|||| 
Target 5' acagaGGAGAGG-AGGGAGGa 3'
118 - 137 131.00 -15.80
3
miRNA  3' gaUACC-CA---CCCUGUCUCUCCc 5'
            |||| ||    ||:||||| || 
Target 5' tcATGGAGTTTCTGGGCAGAGTGGa 3'
789 - 813 131.00 -18.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30171737 5 COSMIC
COSN31509757 9 COSMIC
COSN30526670 19 COSMIC
COSN30492581 25 COSMIC
COSN30484730 51 COSMIC
COSN26988849 70 COSMIC
COSN13920334 72 COSMIC
COSN30466700 74 COSMIC
COSN30178801 85 COSMIC
COSN1262855 122 COSMIC
COSN30165566 124 COSMIC
COSN30464007 132 COSMIC
COSN28765937 254 COSMIC
COSN9167044 303 COSMIC
COSN19192652 377 COSMIC
COSN17007471 467 COSMIC
COSN32063835 544 COSMIC
COSN1262854 608 COSMIC
COSN31522557 626 COSMIC
COSN26664715 660 COSMIC
COSN30176371 774 COSMIC
COSN28770484 779 COSMIC
COSN30158106 822 COSMIC
COSN28768182 857 COSMIC
COSN31568680 886 COSMIC
COSN31531610 1127 COSMIC
COSN20117541 1180 COSMIC
COSN31531222 1336 COSMIC
COSN30158017 1388 COSMIC
COSN4974682 1393 COSMIC
COSN10031286 1662 COSMIC
COSN8019981 1703 COSMIC
COSN19660877 1706 COSMIC
COSN31513220 1780 COSMIC
COSN31609688 1912 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs201416535 3 dbSNP
rs776445465 4 dbSNP
rs1248785934 5 dbSNP
rs768397129 7 dbSNP
rs1481409960 8 dbSNP
rs1274983329 9 dbSNP
rs1209504772 12 dbSNP
rs1234161992 15 dbSNP
rs1233569670 19 dbSNP
rs775058732 23 dbSNP
rs745825547 24 dbSNP
rs562305338 27 dbSNP
rs192698929 28 dbSNP
rs749063872 37 dbSNP
rs921675817 41 dbSNP
rs1218537214 44 dbSNP
rs1392978017 45 dbSNP
rs1263730397 47 dbSNP
rs781433225 48 dbSNP
rs758378782 49 dbSNP
rs372383030 52 dbSNP
rs995093464 57 dbSNP
rs1269623965 63 dbSNP
rs1278753397 65 dbSNP
rs1217833753 71 dbSNP
rs557684878 72 dbSNP
rs1017969995 83 dbSNP
rs1159657607 85 dbSNP
rs1345062917 86 dbSNP
rs1429297770 90 dbSNP
rs1286576222 100 dbSNP
rs984126986 103 dbSNP
rs199532307 111 dbSNP
rs1441164919 119 dbSNP
rs970973936 120 dbSNP
rs1330015983 123 dbSNP
rs149436594 123 dbSNP
rs779234668 133 dbSNP
rs1241999733 137 dbSNP
rs1284719955 141 dbSNP
rs1042057600 146 dbSNP
rs537337630 147 dbSNP
rs1267286393 148 dbSNP
rs578151693 173 dbSNP
rs893037488 174 dbSNP
rs557906681 176 dbSNP
rs1401732101 180 dbSNP
rs534430892 181 dbSNP
rs1399454206 191 dbSNP
rs1464421729 197 dbSNP
rs1427642091 199 dbSNP
rs959488714 206 dbSNP
rs1032381795 207 dbSNP
rs796156878 208 dbSNP
rs1000924039 209 dbSNP
rs189322342 211 dbSNP
rs1372418657 216 dbSNP
rs548575912 223 dbSNP
rs1020094863 229 dbSNP
rs535380996 232 dbSNP
rs1258673294 239 dbSNP
rs1197885108 241 dbSNP
rs1271395979 242 dbSNP
rs41278899 244 dbSNP
rs890366757 248 dbSNP
rs950287985 250 dbSNP
rs1305570252 252 dbSNP
rs1051465093 253 dbSNP
rs3747223 254 dbSNP
rs1415096614 255 dbSNP
rs952299373 255 dbSNP
rs1475185192 256 dbSNP
rs1366547603 257 dbSNP
rs868817086 258 dbSNP
rs1037456599 260 dbSNP
rs1353561453 261 dbSNP
rs1439674098 261 dbSNP
rs184794215 261 dbSNP
rs201025653 261 dbSNP
rs908049113 269 dbSNP
rs890843395 270 dbSNP
rs3747222 273 dbSNP
rs564328484 274 dbSNP
rs949691866 276 dbSNP
rs1436314915 277 dbSNP
rs918167090 278 dbSNP
rs990815363 282 dbSNP
rs1485617750 283 dbSNP
rs1186496347 290 dbSNP
rs1415012505 299 dbSNP
rs569686056 301 dbSNP
rs1168003620 303 dbSNP
rs547581237 305 dbSNP
rs1407903507 307 dbSNP
rs925248392 310 dbSNP
rs528607122 311 dbSNP
rs1054366577 316 dbSNP
rs979945184 319 dbSNP
rs966792402 320 dbSNP
rs191761024 327 dbSNP
rs905845374 328 dbSNP
rs41278897 336 dbSNP
rs1046263493 338 dbSNP
rs1221201867 339 dbSNP
rs1281476188 344 dbSNP
rs370257847 349 dbSNP
rs1423388356 353 dbSNP
rs1010055618 360 dbSNP
rs954642876 365 dbSNP
rs1160645284 366 dbSNP
rs1030259174 377 dbSNP
rs778494733 378 dbSNP
rs996052595 381 dbSNP
rs1174039536 387 dbSNP
rs1177945156 398 dbSNP
rs900187002 399 dbSNP
rs543143258 411 dbSNP
rs574021525 415 dbSNP
rs1362337503 423 dbSNP
rs1210624128 428 dbSNP
rs1317698385 429 dbSNP
rs1324818863 432 dbSNP
rs1311367105 436 dbSNP
rs563520984 438 dbSNP
rs886170850 450 dbSNP
rs1048401627 457 dbSNP
rs963707512 458 dbSNP
rs41278895 459 dbSNP
rs3810628 467 dbSNP
rs1307810240 468 dbSNP
rs570012125 469 dbSNP
rs1221574720 470 dbSNP
rs756707077 476 dbSNP
rs187249346 477 dbSNP
rs1282940156 478 dbSNP
rs955155591 479 dbSNP
rs1303915265 480 dbSNP
rs1020421595 482 dbSNP
rs557943855 484 dbSNP
rs957190558 486 dbSNP
rs1454234826 500 dbSNP
rs1032952787 507 dbSNP
rs1001440867 511 dbSNP
rs534846391 512 dbSNP
rs925302441 513 dbSNP
rs979444777 516 dbSNP
rs1157094201 522 dbSNP
rs1425617725 523 dbSNP
rs1415934166 524 dbSNP
rs912311320 525 dbSNP
rs1014635793 526 dbSNP
rs1278234836 528 dbSNP
rs571810838 528 dbSNP
rs1218348146 529 dbSNP
rs1488453352 530 dbSNP
rs1047284013 531 dbSNP
rs569626847 531 dbSNP
rs1284856540 532 dbSNP
rs555088122 535 dbSNP
rs929748772 536 dbSNP
rs1322970051 537 dbSNP
rs535190293 540 dbSNP
rs1228200484 541 dbSNP
rs930834724 541 dbSNP
rs973724252 544 dbSNP
rs557970730 545 dbSNP
rs1400986832 546 dbSNP
rs1360195888 547 dbSNP
rs1287308281 550 dbSNP
rs1180835454 551 dbSNP
rs1361940606 552 dbSNP
rs945478331 554 dbSNP
rs943644091 557 dbSNP
rs866504877 559 dbSNP
rs913978178 560 dbSNP
rs1350494165 561 dbSNP
rs1165415671 562 dbSNP
rs987254792 563 dbSNP
rs954527256 564 dbSNP
rs1415578167 565 dbSNP
rs1195653056 576 dbSNP
rs986492600 579 dbSNP
rs955208595 586 dbSNP
rs913021603 589 dbSNP
rs1234492415 595 dbSNP
rs1293354540 602 dbSNP
rs1030144602 605 dbSNP
rs974670109 608 dbSNP
rs569667656 610 dbSNP
rs1333601360 613 dbSNP
rs964609518 614 dbSNP
rs988542849 620 dbSNP
rs1262074551 624 dbSNP
rs1480766412 631 dbSNP
rs957221080 637 dbSNP
rs1202963510 643 dbSNP
rs1016366493 646 dbSNP
rs1486606111 646 dbSNP
rs879132406 647 dbSNP
rs1265454748 650 dbSNP
rs1005882610 652 dbSNP
rs1296790691 654 dbSNP
rs970007853 654 dbSNP
rs1377709027 655 dbSNP
rs115920086 664 dbSNP
rs1014296154 665 dbSNP
rs539736848 666 dbSNP
rs1013249676 667 dbSNP
rs1219685828 668 dbSNP
rs1307682505 670 dbSNP
rs1047829236 672 dbSNP
rs1349705098 673 dbSNP
rs896677499 679 dbSNP
rs570720413 685 dbSNP
rs562124514 687 dbSNP
rs527532662 688 dbSNP
rs1368405112 690 dbSNP
rs1293084669 692 dbSNP
rs1484669293 706 dbSNP
rs539605176 709 dbSNP
rs943508386 713 dbSNP
rs755335951 714 dbSNP
rs1392267201 716 dbSNP
rs754054010 722 dbSNP
rs1168684720 723 dbSNP
rs913849760 726 dbSNP
rs986920689 728 dbSNP
rs182909720 734 dbSNP
rs934033886 737 dbSNP
rs923127678 739 dbSNP
rs974555411 744 dbSNP
rs1296691227 752 dbSNP
rs1290090474 755 dbSNP
rs1465976483 758 dbSNP
rs6007365 774 dbSNP
rs730773 779 dbSNP
rs985080442 781 dbSNP
rs192305250 782 dbSNP
rs1279394786 784 dbSNP
rs1345614272 791 dbSNP
rs543415238 797 dbSNP
rs867210767 798 dbSNP
rs1485546249 799 dbSNP
rs1184868781 800 dbSNP
rs767527106 818 dbSNP
rs1454892968 820 dbSNP
rs1192524869 827 dbSNP
rs896228377 829 dbSNP
rs1033835125 830 dbSNP
rs1160390773 835 dbSNP
rs1345136117 836 dbSNP
rs1452376294 840 dbSNP
rs1002328014 846 dbSNP
rs1317997336 847 dbSNP
rs147605628 848 dbSNP
rs189041064 849 dbSNP
rs1043983278 851 dbSNP
rs993138709 855 dbSNP
rs762980 857 dbSNP
rs1235881610 863 dbSNP
rs1316292108 864 dbSNP
rs1313059297 871 dbSNP
rs892479198 876 dbSNP
rs1188231514 878 dbSNP
rs1438859896 879 dbSNP
rs1026290103 882 dbSNP
rs1251382713 883 dbSNP
rs994759208 884 dbSNP
rs1178165289 892 dbSNP
rs1333312438 895 dbSNP
rs572343649 900 dbSNP
rs762979 901 dbSNP
rs1419466288 904 dbSNP
rs184066223 904 dbSNP
rs111813571 917 dbSNP
rs890601287 918 dbSNP
rs943225476 919 dbSNP
rs775065646 920 dbSNP
rs1467374325 921 dbSNP
rs1444045721 931 dbSNP
rs41278893 935 dbSNP
rs945633407 936 dbSNP
rs984744415 938 dbSNP
rs1295187110 951 dbSNP
rs892695828 953 dbSNP
rs566170368 957 dbSNP
rs1287934025 959 dbSNP
rs1439813257 962 dbSNP
rs868799725 963 dbSNP
rs918960416 969 dbSNP
rs1232714185 970 dbSNP
rs780867812 978 dbSNP
rs1190783539 985 dbSNP
rs935643720 990 dbSNP
rs1475215464 991 dbSNP
rs1452064321 992 dbSNP
rs1411129576 1001 dbSNP
rs1239416799 1003 dbSNP
rs1411339543 1008 dbSNP
rs925731905 1014 dbSNP
rs1437829746 1015 dbSNP
rs1353764103 1022 dbSNP
rs371145769 1023 dbSNP
rs1314588510 1025 dbSNP
rs979828846 1027 dbSNP
rs948608275 1028 dbSNP
rs1249017913 1030 dbSNP
rs1341709374 1031 dbSNP
rs563744693 1031 dbSNP
rs1272739920 1032 dbSNP
rs539018566 1034 dbSNP
rs145299086 1035 dbSNP
rs992650729 1037 dbSNP
rs1279924459 1038 dbSNP
rs950696527 1040 dbSNP
rs1355958894 1047 dbSNP
rs762978 1057 dbSNP
rs1235290724 1059 dbSNP
rs534067265 1066 dbSNP
rs968260873 1076 dbSNP
rs1022855784 1081 dbSNP
rs1009849999 1085 dbSNP
rs1186809982 1089 dbSNP
rs1418353238 1094 dbSNP
rs1427531117 1097 dbSNP
rs748702845 1099 dbSNP
rs1375964209 1100 dbSNP
rs568292272 1107 dbSNP
rs1233029911 1113 dbSNP
rs1332259355 1116 dbSNP
rs998178487 1123 dbSNP
rs899801116 1125 dbSNP
rs1397602930 1126 dbSNP
rs548055213 1127 dbSNP
rs1236899996 1131 dbSNP
rs4392353 1140 dbSNP
rs890517499 1141 dbSNP
rs1275887264 1143 dbSNP
rs909060388 1144 dbSNP
rs1049357445 1145 dbSNP
rs139725813 1146 dbSNP
rs1469163325 1148 dbSNP
rs79834698 1153 dbSNP
rs991822272 1157 dbSNP
rs1453720803 1160 dbSNP
rs1170676290 1163 dbSNP
rs1387066964 1170 dbSNP
rs960362750 1175 dbSNP
rs904174055 1176 dbSNP
rs397807771 1182 dbSNP
rs59989372 1182 dbSNP
rs1044035286 1183 dbSNP
rs1304604015 1183 dbSNP
rs926264949 1184 dbSNP
rs980500391 1189 dbSNP
rs550150302 1193 dbSNP
rs533199417 1194 dbSNP
rs1010146223 1196 dbSNP
rs1057372643 1197 dbSNP
rs1205176481 1200 dbSNP
rs1204676686 1201 dbSNP
rs957012031 1202 dbSNP
rs1029927501 1204 dbSNP
rs1463261419 1206 dbSNP
rs779109870 1211 dbSNP
rs998400756 1218 dbSNP
rs929148405 1226 dbSNP
rs1348588670 1234 dbSNP
rs919217775 1236 dbSNP
rs1196510537 1237 dbSNP
rs114796016 1241 dbSNP
rs1246838122 1252 dbSNP
rs1470493870 1259 dbSNP
rs5766149 1264 dbSNP
rs910566507 1265 dbSNP
rs1005665202 1268 dbSNP
rs527956605 1269 dbSNP
rs1362121805 1274 dbSNP
rs1298397907 1280 dbSNP
rs1021605846 1281 dbSNP
rs1399650626 1288 dbSNP
rs1287154026 1292 dbSNP
rs1326375422 1294 dbSNP
rs1234609911 1298 dbSNP
rs56034233 1302 dbSNP
rs542018110 1305 dbSNP
rs929126204 1306 dbSNP
rs747028051 1307 dbSNP
rs1252465298 1308 dbSNP
rs1056325722 1313 dbSNP
rs939240341 1314 dbSNP
rs1476192865 1315 dbSNP
rs956840545 1322 dbSNP
rs369159266 1326 dbSNP
rs980825178 1327 dbSNP
rs558893809 1328 dbSNP
rs1397747782 1330 dbSNP
rs1409604894 1332 dbSNP
rs1306657337 1336 dbSNP
rs6007364 1338 dbSNP
rs987873432 1339 dbSNP
rs556033431 1341 dbSNP
rs1320718543 1343 dbSNP
rs750596490 1357 dbSNP
rs1056882313 1358 dbSNP
rs545875732 1359 dbSNP
rs929167403 1360 dbSNP
rs767615187 1366 dbSNP
rs1486636095 1368 dbSNP
rs1188723280 1372 dbSNP
rs919078831 1375 dbSNP
rs1037469037 1376 dbSNP
rs964277199 1377 dbSNP
rs56400017 1378 dbSNP
rs375267128 1388 dbSNP
rs751501355 1390 dbSNP
rs553783057 1392 dbSNP
rs569539921 1393 dbSNP
rs994237857 1394 dbSNP
rs1227342042 1395 dbSNP
rs1295196182 1397 dbSNP
rs956744848 1399 dbSNP
rs568324835 1401 dbSNP
rs1255350042 1407 dbSNP
rs757040552 1412 dbSNP
rs372407178 1413 dbSNP
rs1262648773 1415 dbSNP
rs969635052 1420 dbSNP
rs1187040980 1421 dbSNP
rs1455080145 1424 dbSNP
rs547825275 1425 dbSNP
rs905114734 1425 dbSNP
rs1163361430 1428 dbSNP
rs368684706 1430 dbSNP
rs1013038961 1434 dbSNP
rs1388893077 1436 dbSNP
rs762726585 1439 dbSNP
rs537595311 1448 dbSNP
rs895468547 1449 dbSNP
rs145730351 1456 dbSNP
rs149771250 1458 dbSNP
rs539529728 1459 dbSNP
rs935039536 1460 dbSNP
rs922795975 1466 dbSNP
rs976901104 1469 dbSNP
rs376612588 1470 dbSNP
rs1207132876 1471 dbSNP
rs1211692635 1475 dbSNP
rs1037501720 1477 dbSNP
rs1018936377 1482 dbSNP
rs984357800 1488 dbSNP
rs186043629 1490 dbSNP
rs1025612613 1491 dbSNP
rs371460941 1496 dbSNP
rs895884654 1497 dbSNP
rs1034854285 1503 dbSNP
rs1337100391 1510 dbSNP
rs1421437720 1511 dbSNP
rs1160640971 1512 dbSNP
rs1003321752 1527 dbSNP
rs1412155690 1538 dbSNP
rs1276225932 1542 dbSNP
rs1441053641 1546 dbSNP
rs905000080 1558 dbSNP
rs1396258300 1572 dbSNP
rs12106501 1575 dbSNP
rs988114178 1578 dbSNP
rs935403126 1593 dbSNP
rs547358550 1594 dbSNP
rs1328485880 1601 dbSNP
rs759288969 1604 dbSNP
rs893477186 1606 dbSNP
rs758499398 1607 dbSNP
rs935093411 1611 dbSNP
rs1221255488 1613 dbSNP
rs527988059 1616 dbSNP
rs922345034 1623 dbSNP
rs1041270074 1633 dbSNP
rs1035380717 1635 dbSNP
rs942855637 1637 dbSNP
rs182555715 1646 dbSNP
rs1015963060 1647 dbSNP
rs984789970 1648 dbSNP
rs139808634 1649 dbSNP
rs1463333379 1653 dbSNP
rs933268193 1654 dbSNP
rs776388391 1656 dbSNP
rs1393287197 1663 dbSNP
rs1349819708 1685 dbSNP
rs901716862 1688 dbSNP
rs918604670 1700 dbSNP
rs972704681 1702 dbSNP
rs960147433 1703 dbSNP
rs1035743945 1704 dbSNP
rs1001534569 1705 dbSNP
rs1206342496 1706 dbSNP
rs969645751 1708 dbSNP
rs1023438788 1714 dbSNP
rs916769898 1715 dbSNP
rs1011269101 1724 dbSNP
rs992712303 1724 dbSNP
rs1203614888 1733 dbSNP
rs893706605 1741 dbSNP
rs1472918063 1745 dbSNP
rs752990880 1749 dbSNP
rs960990644 1754 dbSNP
rs879240066 1756 dbSNP
rs1025818056 1762 dbSNP
rs1052570708 1763 dbSNP
rs999184369 1764 dbSNP
rs900806859 1771 dbSNP
rs1369840374 1782 dbSNP
rs1427794118 1791 dbSNP
rs531853206 1799 dbSNP
rs1040820798 1801 dbSNP
rs1447410509 1803 dbSNP
rs1282595242 1808 dbSNP
rs1229562649 1810 dbSNP
rs1346535517 1810 dbSNP
rs1364394275 1810 dbSNP
rs1340645691 1817 dbSNP
rs942405908 1820 dbSNP
rs1279954067 1821 dbSNP
rs911405970 1824 dbSNP
rs1048534707 1825 dbSNP
rs1298076972 1827 dbSNP
rs1440505434 1829 dbSNP
rs1028826074 1834 dbSNP
rs1450985627 1848 dbSNP
rs997722416 1851 dbSNP
rs1361214480 1853 dbSNP
rs563084163 1860 dbSNP
rs931594185 1870 dbSNP
rs150637729 1871 dbSNP
rs972923720 1875 dbSNP
rs999552244 1879 dbSNP
rs1373868240 1886 dbSNP
rs576987032 1887 dbSNP
rs1332324856 1889 dbSNP
rs960032677 1894 dbSNP
rs1043720167 1896 dbSNP
rs928615781 1897 dbSNP
rs1320303563 1898 dbSNP
rs142829843 1899 dbSNP
rs1236973150 1906 dbSNP
rs535941961 1906 dbSNP
rs770610734 1908 dbSNP
rs1344959017 1909 dbSNP
rs1218097758 1912 dbSNP
rs970155045 1913 dbSNP
rs1465966010 1920 dbSNP
rs190286580 1921 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000403565.1 | 3UTR | AGGAGAGGAGGGAGGAAGAGCUGGGCGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000403565.1 | 3UTR | AGAGGAGGGAGGAAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000403565.1 | 3UTR | AGAGGAGGGAGGAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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