pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF785   
Synonyms -
Description zinc finger protein 785
Transcript NM_152458   
Expression
Putative miRNA Targets on ZNF785
3'UTR of ZNF785
(miRNA target sites are highlighted)
>ZNF785|NM_152458|3'UTR
   1 TGGCGTTCACACAAACTGGTCAGCGTTTCCCTGGAGAGGAAGAGGCAAGGTTTGTGTATTTGGGGGATAAGGAAAGGAAG
  81 TGGGCGTTTGAGGAAAACAAAGTTCTGCCTTAGGTAAAAAGCAGAGGTAGGGGCACAGAGGGCTGTGGGGAGGAGGCAGG
 161 AATCTGAAAAGGTGCCTGGGGGTTGACCCCATTTTCTGAAGCTCCAGCACACAGGGCCCCGTGTTCACGTCCCATCCTTC
 241 ACTGAAAACCATTCACCTAACTGGCTTTTCCTTCATGATTGTTCTCTCCCTTGTAGCTCTCTGCTTTTTGGCCTGTATCT
 321 CTCCTACTCCTCTGAGATGGGGTCCCCTACATTCCAGTGCCTATTAAAGGAGCCTGCACCCACTCTGGACCCCCCAGAAT
 401 AGAGGGGATACCTCAGGCCTGTCCCTCGGCTGGTGGGGGGGGCGGAGCTCATCCCAGGATTCTTTTCTTTTTTTTGAGAT
 481 GGAGTCATGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGC
 561 CATTCTCTGCCTCAGCCTTCCCATTAGCTGGGATTACAGGCATGCGCCACCAGGCCCAGCTAATTTTTGTGCTGTTAGTA
 641 GAGACGGGGTTCCACCATCTTGGCCAGGCTGGTCTTGAATTCCTGACCTCGTGATCCACCCGCCTCGGCGTCTCAAAGTG
 721 CTGGGATTACAAGCGTGAGCCACCGACCCCTGCCGAGGATTCTGCCTTTTACCAATGCAGGTGAAACATCTGGCAAGGAG
 801 ACACCTGGAGTGTAGGTGTTCCTTGGTCTTGAAGACCTAGAGGTGGCCATAGAGAGGACAGTGGCCTCAGGTGGGGAACT
 881 CCCCCCCCACTCTCATTCTGCAAGTGCACAAACTATCAAACATAGCGGACTCTGGAACTGGGCCAACTCTTCACTGTATG
 961 CATTAGTGATTGCAGTGTTTTTTTCTTCTTCAGATATTTGCATGTTCCCTGGATTTTGTATTTTTTGATAAAGATATATT
1041 CTTGGGCCACAGTAGCTGGAGATATAATGCCGGAGGATTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTGTCTCTAT
1121 TGCCTGGGCTGGAGTGCAGTGGCCCAAGCTACGCTCACTGCAAGCTCCACCTCCTGGGTTCACACCATTCTCCTGCTTCA
1201 GTCTCCCGAGTAGCTGGAATTACAAGCACCCGCCACCACGCCCAACTAATATTTTGTATTTTTAGTAGAGACGGGGGTTT
1281 CACCGTGTTAGCCAGGATGGTCTCGATCTCCTGACTTCGTGATCCTCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAG
1361 GCGTGAGCCACTGCACCCAGCCTCTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTAGAGTGCAATGGCA
1441 TGATCTTGGCTCACTGCAACCTCCGCCTCCTAGGTTCAAGCGATTCTCCTGCCCCAGCCTCTTGAGTAGCTGGGATTACA
1521 GGCACCCACGACCATGCCTGGCTAATTGCATTTTTACTAGAGACAGGTTTCACCATGTTGGCCAGGCTGGTCTCCAATTC
1601 CTGACCTCAGGTGATCCACCCGACTTGGCCTCCCAAAGTTCTGGGATTACATTTTTTTTTTAAAGAAAGAATAAATTAAT
1681 TGTGATTAAAGTTGAAATCAAGGCATAGTCTTTCCAGTCTAATTTTTACTGTAATGCTTGTATGTCAACAGTTATGAAGG
1761 CCAGGCGCGGTGGCTCACGCCTGTAATCCTAGCAGTTTGGGAGGCTGAGGAGGGTGGATCACTTAAGGTCAAGAGTTCAA
1841 GACCAGCCTGGCCAATATGGTGAAACCCCATCTCTACTAAAAATACC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' ugCCGAUCACCUG-GUCCACUUCa 5'
            ||  ||||| | ||||||::| 
Target 5' gaGGACAGTGGCCTCAGGTGGGGa 3'
854 - 877 141.00 -24.30
2
miRNA  3' ugCCGAUCACCUGG-----UCCACUUCa 5'
            ||  :|||||:|     |||| ||| 
Target 5' gaGGAGGGTGGATCACTTAAGGTCAAGa 3'
1807 - 1834 133.00 -19.10
3
miRNA  3' ugccGAUCACCUGGUCCACUUca 5'
              | | ||   ||||||||  
Target 5' tttaCCAATG---CAGGTGAAac 3'
768 - 787 132.00 -10.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN27006563 5 COSMIC
COSN31579859 25 COSMIC
COSN13666169 29 COSMIC
COSN30513321 31 COSMIC
COSN31507041 36 COSMIC
COSN30458167 38 COSMIC
COSN30164752 43 COSMIC
COSN30127835 51 COSMIC
COSN2529491 60 COSMIC
COSN20078613 85 COSMIC
COSN30539169 133 COSMIC
COSN5759680 191 COSMIC
COSN16130306 734 COSMIC
COSN20730731 760 COSMIC
COSN25418792 956 COSMIC
COSN23965357 1884 COSMIC
COSN23889970 1887 COSMIC
rs74249949 1771 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs756545898 4 dbSNP
rs763927885 5 dbSNP
rs754990455 12 dbSNP
rs767759524 15 dbSNP
rs1293841669 17 dbSNP
rs759992352 21 dbSNP
rs772960015 22 dbSNP
rs765004385 25 dbSNP
rs1293771216 26 dbSNP
rs761607847 29 dbSNP
rs1047659535 33 dbSNP
rs199846271 34 dbSNP
rs768281012 36 dbSNP
rs746910013 38 dbSNP
rs1267636874 44 dbSNP
rs775514942 50 dbSNP
rs1490933296 53 dbSNP
rs751421284 56 dbSNP
rs920609517 56 dbSNP
rs1250122893 62 dbSNP
rs771784195 70 dbSNP
rs184075766 74 dbSNP
rs1331962788 76 dbSNP
rs140588038 78 dbSNP
rs779055328 85 dbSNP
rs144729796 86 dbSNP
rs1302284825 90 dbSNP
rs1243823645 93 dbSNP
rs749563389 94 dbSNP
rs560246597 95 dbSNP
rs191599055 97 dbSNP
rs1187077931 98 dbSNP
rs982721657 106 dbSNP
rs1474229101 107 dbSNP
rs970918031 129 dbSNP
rs1258014282 131 dbSNP
rs1395481750 132 dbSNP
rs1021649503 140 dbSNP
rs529905658 149 dbSNP
rs1196771315 151 dbSNP
rs994944510 153 dbSNP
rs1400546623 156 dbSNP
rs963513983 175 dbSNP
rs775366301 178 dbSNP
rs1432134362 189 dbSNP
rs1325770592 190 dbSNP
rs765460688 191 dbSNP
rs906322971 208 dbSNP
rs1275588813 212 dbSNP
rs1293591129 215 dbSNP
rs1232799561 216 dbSNP
rs1032643050 217 dbSNP
rs999782992 220 dbSNP
rs79199963 229 dbSNP
rs1447307873 236 dbSNP
rs563987535 240 dbSNP
rs1255313074 242 dbSNP
rs759707303 249 dbSNP
rs1190132791 250 dbSNP
rs1369316250 251 dbSNP
rs1469847988 267 dbSNP
rs1156993679 271 dbSNP
rs543785811 272 dbSNP
rs1420619509 280 dbSNP
rs1312870590 294 dbSNP
rs576475357 297 dbSNP
rs1009168838 301 dbSNP
rs1416142365 315 dbSNP
rs890279915 318 dbSNP
rs776801801 325 dbSNP
rs921090479 326 dbSNP
rs1351217638 334 dbSNP
rs564626953 334 dbSNP
rs1278171698 336 dbSNP
rs1304866401 342 dbSNP
rs1486595674 346 dbSNP
rs1464240733 349 dbSNP
rs1039595600 350 dbSNP
rs929227370 353 dbSNP
rs1464220653 354 dbSNP
rs1060148 355 dbSNP
rs1365223351 358 dbSNP
rs899045430 363 dbSNP
rs1179930103 364 dbSNP
rs943428886 370 dbSNP
rs540279382 373 dbSNP
rs771332489 381 dbSNP
rs1393848004 386 dbSNP
rs1437156013 388 dbSNP
rs1173620205 391 dbSNP
rs572852053 393 dbSNP
rs1395151858 394 dbSNP
rs1037715991 396 dbSNP
rs1389173710 406 dbSNP
rs1330542018 407 dbSNP
rs1335960415 413 dbSNP
rs1439952080 421 dbSNP
rs1301026317 422 dbSNP
rs912007936 427 dbSNP
rs1238041879 428 dbSNP
rs1338893402 433 dbSNP
rs1177314497 434 dbSNP
rs1252986922 435 dbSNP
rs987847074 436 dbSNP
rs74015016 437 dbSNP
rs1200282353 440 dbSNP
rs186747185 441 dbSNP
rs919468145 441 dbSNP
rs1279403356 442 dbSNP
rs982201308 442 dbSNP
rs200277882 443 dbSNP
rs963634594 443 dbSNP
rs747749164 444 dbSNP
rs575170080 469 dbSNP
rs1199988889 476 dbSNP
rs1213316209 476 dbSNP
rs747322513 481 dbSNP
rs988227662 482 dbSNP
rs958290280 483 dbSNP
rs1261691638 491 dbSNP
rs925530513 493 dbSNP
rs1427296166 496 dbSNP
rs1195898343 505 dbSNP
rs1423740932 518 dbSNP
rs1474558055 519 dbSNP
rs980988144 523 dbSNP
rs1352738991 527 dbSNP
rs1306904850 537 dbSNP
rs1396201033 544 dbSNP
rs978434829 560 dbSNP
rs1454508890 567 dbSNP
rs970871576 588 dbSNP
rs964389160 592 dbSNP
rs1382461540 596 dbSNP
rs1341053490 602 dbSNP
rs1332893979 606 dbSNP
rs1024741165 614 dbSNP
rs1393824171 619 dbSNP
rs1341281294 621 dbSNP
rs1232738910 632 dbSNP
rs1386617573 636 dbSNP
rs1017799623 637 dbSNP
rs753380499 637 dbSNP
rs1323698980 649 dbSNP
rs1420619459 652 dbSNP
rs1222537661 653 dbSNP
rs1380069220 654 dbSNP
rs1008659063 657 dbSNP
rs1157287099 659 dbSNP
rs1474045543 667 dbSNP
rs1207416880 668 dbSNP
rs1238601059 672 dbSNP
rs1186885253 677 dbSNP
rs367564037 684 dbSNP
rs954590205 690 dbSNP
rs929158659 698 dbSNP
rs1032044916 699 dbSNP
rs1026156157 702 dbSNP
rs1264058959 707 dbSNP
rs1419620562 710 dbSNP
rs993298430 725 dbSNP
rs773834623 730 dbSNP
rs866866311 734 dbSNP
rs1424061456 735 dbSNP
rs1217630036 736 dbSNP
rs899117407 740 dbSNP
rs1000780617 744 dbSNP
rs1283607410 747 dbSNP
rs183392283 755 dbSNP
rs1298798061 760 dbSNP
rs1374752404 772 dbSNP
rs1414288650 773 dbSNP
rs1311175328 777 dbSNP
rs1381371492 785 dbSNP
rs1356911785 797 dbSNP
rs772389338 798 dbSNP
rs1229118994 807 dbSNP
rs1306480162 809 dbSNP
rs1002639502 810 dbSNP
rs1241913585 811 dbSNP
rs943896924 816 dbSNP
rs9934806 822 dbSNP
rs1209304832 836 dbSNP
rs1259032032 846 dbSNP
rs570820646 849 dbSNP
rs949498883 859 dbSNP
rs779659414 862 dbSNP
rs929266948 863 dbSNP
rs755859128 872 dbSNP
rs1052585575 875 dbSNP
rs1394209958 876 dbSNP
rs1432813509 879 dbSNP
rs59474645 880 dbSNP
rs925560008 881 dbSNP
rs1448848788 882 dbSNP
rs1297876228 884 dbSNP
rs1371423924 885 dbSNP
rs1415099937 886 dbSNP
rs942271222 887 dbSNP
rs780972197 888 dbSNP
rs1312334342 889 dbSNP
rs981319940 889 dbSNP
rs749241187 895 dbSNP
rs1458839649 900 dbSNP
rs1471815292 905 dbSNP
rs1178815113 913 dbSNP
rs970939401 915 dbSNP
rs1452270639 923 dbSNP
rs964614505 925 dbSNP
rs1425773789 926 dbSNP
rs534271935 927 dbSNP
rs1169784258 929 dbSNP
rs1352793876 931 dbSNP
rs74516047 941 dbSNP
rs190935743 946 dbSNP
rs529868613 954 dbSNP
rs1223432311 962 dbSNP
rs1451980390 965 dbSNP
rs1288973858 978 dbSNP
rs1031992353 982 dbSNP
rs1207980880 985 dbSNP
rs1341453655 1004 dbSNP
rs1278248985 1010 dbSNP
rs1217522163 1026 dbSNP
rs780099154 1031 dbSNP
rs954495677 1036 dbSNP
rs1198891461 1039 dbSNP
rs562441801 1042 dbSNP
rs1026063263 1043 dbSNP
rs755993796 1048 dbSNP
rs1457017124 1058 dbSNP
rs1223464511 1061 dbSNP
rs993370275 1065 dbSNP
rs1247254950 1069 dbSNP
rs1284833234 1072 dbSNP
rs1438985510 1074 dbSNP
rs1350843657 1076 dbSNP
rs1323390953 1077 dbSNP
rs975958019 1080 dbSNP
rs1403149314 1081 dbSNP
rs1478804507 1081 dbSNP
rs1394005755 1084 dbSNP
rs963188704 1084 dbSNP
rs1018207244 1101 dbSNP
rs1218700136 1101 dbSNP
rs1287567004 1101 dbSNP
rs1292352654 1101 dbSNP
rs1325982978 1101 dbSNP
rs1341908565 1101 dbSNP
rs1350786477 1101 dbSNP
rs1374424670 1101 dbSNP
rs1430661213 1101 dbSNP
rs760679001 1101 dbSNP
rs1213563626 1102 dbSNP
rs1265241372 1103 dbSNP
rs550499799 1109 dbSNP
rs1194440625 1110 dbSNP
rs1477548257 1110 dbSNP
rs1417203893 1115 dbSNP
rs111379692 1131 dbSNP
rs1414986493 1133 dbSNP
rs1400488741 1135 dbSNP
rs1316917760 1136 dbSNP
rs116364364 1139 dbSNP
rs905069484 1145 dbSNP
rs1311774915 1151 dbSNP
rs148651854 1152 dbSNP
rs897939913 1153 dbSNP
rs572859803 1170 dbSNP
rs1284354637 1186 dbSNP
rs1349770070 1206 dbSNP
rs1013996798 1207 dbSNP
rs1037654713 1208 dbSNP
rs745727317 1214 dbSNP
rs1210011303 1215 dbSNP
rs560853986 1217 dbSNP
rs942050586 1223 dbSNP
rs1189962121 1229 dbSNP
rs542417969 1231 dbSNP
rs369985222 1232 dbSNP
rs936867754 1239 dbSNP
rs1420857962 1240 dbSNP
rs1197406386 1265 dbSNP
rs575131624 1268 dbSNP
rs925466749 1270 dbSNP
rs1315549808 1272 dbSNP
rs556806039 1273 dbSNP
rs751311188 1276 dbSNP
rs1264545510 1277 dbSNP
rs1219448974 1278 dbSNP
rs1040251745 1282 dbSNP
rs942970124 1283 dbSNP
rs1366538756 1284 dbSNP
rs912773878 1285 dbSNP
rs1233482023 1291 dbSNP
rs987191361 1294 dbSNP
rs932972804 1304 dbSNP
rs188448584 1305 dbSNP
rs979066447 1308 dbSNP
rs1437493180 1310 dbSNP
rs1018572691 1316 dbSNP
rs1440627729 1318 dbSNP
rs183810209 1319 dbSNP
rs1376415158 1321 dbSNP
rs971794014 1324 dbSNP
rs558878065 1326 dbSNP
rs963095857 1329 dbSNP
rs1395083547 1331 dbSNP
rs191500377 1334 dbSNP
rs980978843 1335 dbSNP
rs1439880101 1336 dbSNP
rs780819541 1338 dbSNP
rs1178391622 1345 dbSNP
rs1233838076 1346 dbSNP
rs1275533489 1349 dbSNP
rs993992208 1358 dbSNP
rs1196987913 1359 dbSNP
rs1260229416 1362 dbSNP
rs1458536963 1363 dbSNP
rs1213434052 1374 dbSNP
rs897885953 1376 dbSNP
rs1200129294 1381 dbSNP
rs1424770868 1384 dbSNP
rs566938383 1385 dbSNP
rs80309889 1395 dbSNP
rs1172448964 1396 dbSNP
rs1476553581 1396 dbSNP
rs76980856 1396 dbSNP
rs1291606982 1402 dbSNP
rs548441669 1408 dbSNP
rs1387288813 1409 dbSNP
rs1317467148 1413 dbSNP
rs1006138922 1433 dbSNP
rs1216859373 1434 dbSNP
rs1280387813 1437 dbSNP
rs1318831207 1445 dbSNP
rs1232857599 1446 dbSNP
rs969365901 1447 dbSNP
rs1264065512 1449 dbSNP
rs1025308524 1452 dbSNP
rs866736195 1454 dbSNP
rs766613953 1464 dbSNP
rs892451200 1465 dbSNP
rs1030929998 1470 dbSNP
rs113917399 1472 dbSNP
rs1487051812 1480 dbSNP
rs1000922024 1481 dbSNP
rs903910326 1482 dbSNP
rs1456444004 1488 dbSNP
rs1039882937 1495 dbSNP
rs536026816 1507 dbSNP
rs918191320 1512 dbSNP
rs1458213966 1513 dbSNP
rs891418192 1526 dbSNP
rs1157981600 1527 dbSNP
rs1051765237 1529 dbSNP
rs1210271276 1530 dbSNP
rs1300149963 1538 dbSNP
rs758212705 1540 dbSNP
rs935502973 1541 dbSNP
rs1310842741 1552 dbSNP
rs1323942968 1561 dbSNP
rs1245961433 1563 dbSNP
rs918940344 1565 dbSNP
rs1285982906 1566 dbSNP
rs971702047 1567 dbSNP
rs1219373365 1572 dbSNP
rs1263284582 1582 dbSNP
rs1485018490 1585 dbSNP
rs1179820273 1597 dbSNP
rs979182355 1605 dbSNP
rs568669222 1606 dbSNP
rs559566522 1609 dbSNP
rs986897202 1610 dbSNP
rs550362165 1616 dbSNP
rs1421465975 1620 dbSNP
rs955306545 1621 dbSNP
rs1361326776 1622 dbSNP
rs1465596978 1626 dbSNP
rs908947002 1643 dbSNP
rs1375393535 1661 dbSNP
rs1309020560 1662 dbSNP
rs1432062247 1662 dbSNP
rs200478744 1662 dbSNP
rs993939849 1667 dbSNP
rs980669054 1671 dbSNP
rs1304627306 1684 dbSNP
rs962522110 1695 dbSNP
rs1242952840 1710 dbSNP
rs541231708 1715 dbSNP
rs752847414 1716 dbSNP
rs576491877 1719 dbSNP
rs1207384254 1740 dbSNP
rs1024917803 1749 dbSNP
rs1483390638 1753 dbSNP
rs992048030 1760 dbSNP
rs765339887 1766 dbSNP
rs1030962487 1767 dbSNP
rs905298435 1768 dbSNP
rs532243369 1769 dbSNP
rs74249949 1771 dbSNP
rs751267465 1773 dbSNP
rs546559530 1778 dbSNP
rs1052688969 1779 dbSNP
rs1398649080 1781 dbSNP
rs935450510 1786 dbSNP
rs925432025 1799 dbSNP
rs1043959764 1804 dbSNP
rs1217938333 1809 dbSNP
rs1181899671 1811 dbSNP
rs1302796484 1812 dbSNP
rs1312203319 1814 dbSNP
rs1482657476 1825 dbSNP
rs1235315868 1832 dbSNP
rs1197696220 1833 dbSNP
rs1255744156 1834 dbSNP
rs942449355 1844 dbSNP
rs1199004322 1845 dbSNP
rs910992530 1849 dbSNP
rs1487475818 1853 dbSNP
rs986456420 1858 dbSNP
rs1427355023 1865 dbSNP
rs1488443713 1877 dbSNP
rs1287164113 1878 dbSNP
rs1170311758 1883 dbSNP
rs910530450 1884 dbSNP
rs1196080010 1887 dbSNP
rs1332502651 1888 dbSNP
rs1315463199 1889 dbSNP
rs933671198 1898 dbSNP
rs1295733725 1899 dbSNP
rs1378539556 1900 dbSNP
rs918473266 1901 dbSNP
rs1402065460 1904 dbSNP
rs11348361 1905 dbSNP
rs1217458838 1905 dbSNP
rs1288891261 1905 dbSNP
rs1469256290 1905 dbSNP
rs568222780 1905 dbSNP
rs869220413 1905 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' ugCCGAUC--AC-CUGGUCCACuuca 5'
            || |||  || | ||||| |    
Target 5' gaGGAUAGCUUGAGCCCAGGAGu--- 3'
8 - 30
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000470110.1 | 3UTR | GAAGAAGGAGGAUAGCUUGAGCCCAGGAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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