pre-miRNA Information
pre-miRNA hsa-mir-125b-2   
Genomic Coordinates chr21: 16590237 - 16590325
Synonyms MIRN125B2, MIR125B2
Description Homo sapiens miR-125b-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-125b-2-3p
Sequence 54| UCACAAGUCAGGCUCUUGGGAC |75
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 21 + 16590292 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs575583557 6 dbSNP
rs1331783293 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TM9SF4   
Synonyms dJ836N17.2
Description transmembrane 9 superfamily member 4
Transcript NM_014742   
Expression
Putative miRNA Targets on TM9SF4
3'UTR of TM9SF4
(miRNA target sites are highlighted)
>TM9SF4|NM_014742|3'UTR
   1 TTGGAGTGGACCACGGCCAAGCTTGCTCCGTCCTCGGACAGGAAGCCACCCTGCGTGGGGGACTGCAGGCACGCAAAATA
  81 AAATAACTCCTGCTCGTTTGGAATGTAACTCCTGGCACAGTGTTCCTGGATCCTGGGGCTGCGTGGGGGGCGGGAGGGCC
 161 TGTAGATAATCTTGCGTTTTTCGTCATCTTATTCCAGTTCTGTGGGGGATGAGTTTTTTTGTGGGTTGCTTTTTCTTCAG
 241 TGCTAAGAAAGTTCCCTCCAACAGGAACTCTCTGACCTGTTTATTCAGGTGTATTTCTGGTTTGGATTTTTTTTTCCTTC
 321 TTTGTTTTAACAAATGGATCCAGGATGGATAAATCCACCGAGATAAGGGTTTTGGTCACTGTCTCCACCTCAGTTCCTCA
 401 GGGCTGTTGGCCACCCTATGACTAACTGGAAGAGGACACGCCAGAGCTTCAGTGAGGTTTCCGAGCCTCTCCCTGCCCAT
 481 CCTCACCACTGAGGCCACGACAAAGCACAGCTCCAGCTCGGACAGCACCCTCAGTGCCAGCCAGCCTCTGCCAGACCTCT
 561 CTTTCCCTCTTCTCCCCAGCCTCCTCCAGGGCTGCCCAAGGCAGGGTTTCCAGCCAGGCCTCGGGGTCATCTTTTCACCA
 641 GGAGCAAACCCAAGTCTTAGTTGCTACAAGAAAATCCCCTGGAAGTACTGGGGGCCAGGTTCCCCAGACAGCAGGAATTG
 721 CCCCTGTTCAGAGCAGCCGGAGTTTGCTGGACCACAAGGAAGAAGAGAAGAGACTTGCAGTGAACTGTTTTTGTGCCAAG
 801 AAACCCTGGACCTGGGGCCAAGTATTTCCCAAGCCAAGCATCCACTTGTCTGTGTCTGGGAAGGGATGGCCAAGGCCGCT
 881 AGGGTCCTTACCCCTCAGGATCACTCCCCAGCCCTTTCCTCAGGAGGTACCGCTCTCCAAGGTGTGCTAGCAGTGGGCCC
 961 TGCCCAACTTCAGGCAGAACAGGGAGGCCCAGAGATTACAGATCCCCTCCTGTAAGTGGCCAGGCATTCTCTCCCTGCCC
1041 TCTCTGGCCTCTGGGGTCATACTCACTTCTTTAGCCAGCCCCATCCCCTCCACCCCACACCTGAGTTCTTGCCTCCTCCT
1121 TTTGGGGACACCCAAAACACTGCTTGTGAGAAGGAAGATGGAAGGTAAGTTCTGTCGTTCTTTCCCCAATCCCCAGGAAT
1201 GGACAAGAAGCCAACTTAGAAAGAAGGGTCTCACGTGGCTGGCCTGGCTCCTCCGTAGACCCCTGTTCTTTTCAACCTCT
1281 GCCCACCCGTGCATGTCATCACAAACATTTGCTCTTAAGTTACAAGAGACCACATCCACCCAGGGATTAGGGTTCAAGTA
1361 GCAGCTGCTAACCCTTGCACCAGCCCTTGTGGGACTCCCAACACAAGACAAAGCTCAGGATGCTGGTGATGCTAGGAAGA
1441 TGTCCCTCCCCTCACTGCCCCACATTCTCCCAGTGGCTCTACCAGCCTCACCCATCAAACCAGTGAATTTCTCAATCTTG
1521 CCTCACAGTGACTGCAGCGCCAAGCGGCATCCACCAAGCATCAAGTTGGAGAAAAGGGAACCCAAGCAGTAGAGAGCGAT
1601 ATTGGAGTCTTTTGTTCATTCAAATCTTGGATTTTTTTTTTTCCCTAAGAGATTCTCTTTTTAGGGGGAATGGGAAACGG
1681 ACACCTCATAAAGGGTTCAAAGATCATCAATTTTTCTGACTTTTTAAATCATTATCATTATTATTTTTAATTAAAAAAAT
1761 GCCTGTATGCCTTTTTTTGGTCGGATTGTAAATAAATATACCATTGTCCTACTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' caGGGUUCUCGGACUGAACACu 5'
            ||||| |  || :|||||| 
Target 5' caCCCAAAACACT-GCTTGTGa 3'
1129 - 1149 147.00 -19.60
2
miRNA  3' caGGGUUC---UCGGA-CUGAACAcu 5'
            ||||||   ||| |  ||||||  
Target 5' ttCCCAAGCCAAGCATCCACTTGTct 3'
826 - 851 144.00 -16.20
3
miRNA  3' caggGUUCUCGGACUGAACACu 5'
              ||  ||||   |||||| 
Target 5' cttgCACCAGCC---CTTGTGg 3'
1374 - 1392 126.00 -12.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30496472 15 COSMIC
COSN19691744 16 COSMIC
COSN30110413 30 COSMIC
COSN26998754 36 COSMIC
COSN31532760 55 COSMIC
COSN31497902 56 COSMIC
COSN26551319 70 COSMIC
COSN30123525 77 COSMIC
COSN30468356 96 COSMIC
COSN31554699 113 COSMIC
COSN31572487 152 COSMIC
COSN30098420 153 COSMIC
COSN30125767 153 COSMIC
COSN31502834 155 COSMIC
COSN30122726 183 COSMIC
COSN5968695 362 COSMIC
COSN5968696 367 COSMIC
COSN26644414 397 COSMIC
COSN7089152 413 COSMIC
COSN31513390 542 COSMIC
COSN5133761 714 COSMIC
COSN16586859 773 COSMIC
COSN31594116 878 COSMIC
COSN16586885 978 COSMIC
COSN17075785 1417 COSMIC
COSN8345798 1636 COSMIC
COSN24883834 1706 COSMIC
COSN7089153 1754 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759898996 12 dbSNP
rs765377650 15 dbSNP
rs752692033 16 dbSNP
rs758698845 18 dbSNP
rs976764592 21 dbSNP
rs14316 24 dbSNP
rs1209730888 26 dbSNP
rs751424761 30 dbSNP
rs201783577 31 dbSNP
rs1184290510 33 dbSNP
rs371611586 36 dbSNP
rs533979631 37 dbSNP
rs755964911 43 dbSNP
rs1296192645 46 dbSNP
rs1421298418 47 dbSNP
rs779653917 49 dbSNP
rs1410181189 50 dbSNP
rs1174981544 51 dbSNP
rs555563244 56 dbSNP
rs1803426 58 dbSNP
rs756593788 59 dbSNP
rs1173286169 60 dbSNP
rs1477147654 61 dbSNP
rs567448372 62 dbSNP
rs547530739 73 dbSNP
rs1053961248 74 dbSNP
rs1365065331 79 dbSNP
rs893945487 84 dbSNP
rs972590178 90 dbSNP
rs142385874 91 dbSNP
rs766771771 96 dbSNP
rs371364855 97 dbSNP
rs1342418034 100 dbSNP
rs939001668 104 dbSNP
rs577984080 115 dbSNP
rs902873230 116 dbSNP
rs1276248028 129 dbSNP
rs997180080 140 dbSNP
rs1029927766 143 dbSNP
rs888885824 144 dbSNP
rs1056087197 146 dbSNP
rs1007222967 152 dbSNP
rs894888390 153 dbSNP
rs1421511749 154 dbSNP
rs947837122 158 dbSNP
rs1478421912 159 dbSNP
rs1271051659 163 dbSNP
rs1435998024 173 dbSNP
rs532779016 176 dbSNP
rs963233575 177 dbSNP
rs972427592 183 dbSNP
rs1471014493 184 dbSNP
rs1341041914 188 dbSNP
rs1292522552 189 dbSNP
rs1445551361 193 dbSNP
rs1341984097 197 dbSNP
rs1026211448 198 dbSNP
rs971163985 229 dbSNP
rs982147484 232 dbSNP
rs1161925065 235 dbSNP
rs1384781187 239 dbSNP
rs1398262951 240 dbSNP
rs1000381598 243 dbSNP
rs41293126 249 dbSNP
rs754652341 251 dbSNP
rs1417778062 255 dbSNP
rs77871433 262 dbSNP
rs191292524 265 dbSNP
rs1030109236 276 dbSNP
rs775206217 280 dbSNP
rs1235894174 307 dbSNP
rs1457025640 307 dbSNP
rs200973759 307 dbSNP
rs1330096676 311 dbSNP
rs1317917344 316 dbSNP
rs1337924492 317 dbSNP
rs1446200088 318 dbSNP
rs1312476320 321 dbSNP
rs1358284086 325 dbSNP
rs1272487205 333 dbSNP
rs1226489341 334 dbSNP
rs762803418 336 dbSNP
rs1293291575 337 dbSNP
rs1441827012 340 dbSNP
rs1374948049 348 dbSNP
rs1337411276 355 dbSNP
rs867170128 357 dbSNP
rs374099169 360 dbSNP
rs542821514 361 dbSNP
rs1322178441 363 dbSNP
rs1407542672 366 dbSNP
rs6061204 368 dbSNP
rs1439356533 380 dbSNP
rs962839169 400 dbSNP
rs972564142 403 dbSNP
rs1438773853 404 dbSNP
rs1378106683 414 dbSNP
rs1180062603 419 dbSNP
rs1457840191 427 dbSNP
rs1245585556 441 dbSNP
rs918491056 448 dbSNP
rs1453238383 452 dbSNP
rs561186224 453 dbSNP
rs1043062619 460 dbSNP
rs1290410154 463 dbSNP
rs922893092 464 dbSNP
rs1351161054 470 dbSNP
rs1311762752 476 dbSNP
rs991786111 483 dbSNP
rs1370390515 486 dbSNP
rs1273128217 489 dbSNP
rs1439295129 498 dbSNP
rs367679400 499 dbSNP
rs751779245 500 dbSNP
rs1318174154 501 dbSNP
rs1418269437 507 dbSNP
rs1362791702 511 dbSNP
rs761970256 514 dbSNP
rs543797745 520 dbSNP
rs565540805 521 dbSNP
rs918150596 528 dbSNP
rs1169011586 530 dbSNP
rs1188944888 531 dbSNP
rs1448529465 540 dbSNP
rs903618440 541 dbSNP
rs1007295221 548 dbSNP
rs1215740807 557 dbSNP
rs1468634656 557 dbSNP
rs1336474312 558 dbSNP
rs1217680236 561 dbSNP
rs111242773 568 dbSNP
rs1037408604 569 dbSNP
rs1053308240 595 dbSNP
rs1221025424 599 dbSNP
rs1368329197 612 dbSNP
rs1270153200 613 dbSNP
rs1398650655 614 dbSNP
rs1342823130 619 dbSNP
rs1299164814 620 dbSNP
rs532812097 623 dbSNP
rs767612868 624 dbSNP
rs1415703965 630 dbSNP
rs554319978 632 dbSNP
rs558657329 634 dbSNP
rs1192900812 636 dbSNP
rs1476786439 638 dbSNP
rs1324190975 650 dbSNP
rs1029916715 654 dbSNP
rs993330249 662 dbSNP
rs1270701319 664 dbSNP
rs34040279 672 dbSNP
rs1254502957 678 dbSNP
rs1212449645 680 dbSNP
rs1312880054 681 dbSNP
rs1341381429 687 dbSNP
rs1201595274 694 dbSNP
rs889750617 695 dbSNP
rs1461573034 700 dbSNP
rs1205834303 701 dbSNP
rs1006904633 724 dbSNP
rs1026537425 730 dbSNP
rs1449722736 731 dbSNP
rs183091782 739 dbSNP
rs1428001213 740 dbSNP
rs970687872 742 dbSNP
rs779410842 746 dbSNP
rs539586493 756 dbSNP
rs57029404 756 dbSNP
rs1253772362 758 dbSNP
rs1183858894 759 dbSNP
rs557692363 763 dbSNP
rs1483689966 765 dbSNP
rs1003427168 779 dbSNP
rs1033714394 791 dbSNP
rs959359665 794 dbSNP
rs1407335841 800 dbSNP
rs1459099577 806 dbSNP
rs1259293321 822 dbSNP
rs989588284 826 dbSNP
rs1320330594 851 dbSNP
rs1315241404 853 dbSNP
rs1229729654 854 dbSNP
rs915317620 858 dbSNP
rs1292868618 864 dbSNP
rs1443957109 865 dbSNP
rs1401785640 878 dbSNP
rs967169080 881 dbSNP
rs978305774 882 dbSNP
rs922725321 885 dbSNP
rs750433655 890 dbSNP
rs1366551228 900 dbSNP
rs756674943 913 dbSNP
rs1166634916 919 dbSNP
rs1424106297 920 dbSNP
rs1381227248 921 dbSNP
rs1176949798 922 dbSNP
rs1049956993 933 dbSNP
rs1459169285 937 dbSNP
rs573048617 941 dbSNP
rs910255052 942 dbSNP
rs969438574 945 dbSNP
rs1342343883 962 dbSNP
rs1267672806 971 dbSNP
rs566584860 992 dbSNP
rs1050659 994 dbSNP
rs1353370832 995 dbSNP
rs1282506207 1009 dbSNP
rs1237462144 1014 dbSNP
rs1037441237 1017 dbSNP
rs898927197 1019 dbSNP
rs527426148 1020 dbSNP
rs116367751 1023 dbSNP
rs1225049218 1024 dbSNP
rs935100175 1025 dbSNP
rs1053277603 1036 dbSNP
rs138689586 1038 dbSNP
rs1485660009 1039 dbSNP
rs1003501300 1040 dbSNP
rs758424792 1041 dbSNP
rs1033578653 1042 dbSNP
rs959390506 1046 dbSNP
rs1205846955 1051 dbSNP
rs1010925917 1060 dbSNP
rs1441748323 1063 dbSNP
rs764628406 1066 dbSNP
rs1198239645 1067 dbSNP
rs934155177 1069 dbSNP
rs1489867755 1086 dbSNP
rs1192236358 1088 dbSNP
rs1284288642 1092 dbSNP
rs538027784 1094 dbSNP
rs1199352961 1096 dbSNP
rs1022695602 1103 dbSNP
rs1051755146 1105 dbSNP
rs1231904339 1106 dbSNP
rs966823469 1112 dbSNP
rs1430532142 1113 dbSNP
rs978549834 1117 dbSNP
rs890067664 1128 dbSNP
rs1029862771 1129 dbSNP
rs955533770 1136 dbSNP
rs1038407753 1142 dbSNP
rs985697579 1145 dbSNP
rs911460571 1147 dbSNP
rs1025693431 1148 dbSNP
rs941587061 1163 dbSNP
rs1172155983 1177 dbSNP
rs556198694 1178 dbSNP
rs960501889 1185 dbSNP
rs571488552 1190 dbSNP
rs920214974 1198 dbSNP
rs929105555 1200 dbSNP
rs1196296572 1201 dbSNP
rs1288982969 1205 dbSNP
rs1488784959 1215 dbSNP
rs1047933989 1216 dbSNP
rs1199486363 1218 dbSNP
rs576814585 1218 dbSNP
rs112967857 1224 dbSNP
rs1361925765 1227 dbSNP
rs538648106 1229 dbSNP
rs553710176 1235 dbSNP
rs754199158 1236 dbSNP
rs939154978 1239 dbSNP
rs572098143 1246 dbSNP
rs115742080 1255 dbSNP
rs1394483870 1256 dbSNP
rs1404507223 1257 dbSNP
rs923028071 1258 dbSNP
rs1010791556 1261 dbSNP
rs1465622869 1264 dbSNP
rs1422117146 1268 dbSNP
rs1316597916 1269 dbSNP
rs934129436 1271 dbSNP
rs1022306425 1289 dbSNP
rs1262660099 1290 dbSNP
rs1357382448 1292 dbSNP
rs1051300889 1300 dbSNP
rs779098752 1302 dbSNP
rs999653335 1304 dbSNP
rs1030140149 1305 dbSNP
rs866646707 1312 dbSNP
rs985605625 1313 dbSNP
rs1220352666 1338 dbSNP
rs1018373541 1346 dbSNP
rs1339882451 1351 dbSNP
rs746706684 1356 dbSNP
rs1250219133 1372 dbSNP
rs974696433 1378 dbSNP
rs1242958851 1379 dbSNP
rs920312784 1381 dbSNP
rs14086 1384 dbSNP
rs1337565314 1388 dbSNP
rs943006339 1390 dbSNP
rs1398150280 1394 dbSNP
rs11544375 1400 dbSNP
rs202096379 1406 dbSNP
rs576578470 1410 dbSNP
rs1161821745 1413 dbSNP
rs1473940612 1414 dbSNP
rs188370457 1417 dbSNP
rs114684503 1421 dbSNP
rs1438576727 1426 dbSNP
rs573299106 1433 dbSNP
rs896600598 1448 dbSNP
rs1054969747 1450 dbSNP
rs894949257 1451 dbSNP
rs1459354574 1454 dbSNP
rs946652613 1465 dbSNP
rs532801050 1468 dbSNP
rs1358135025 1483 dbSNP
rs1316030827 1497 dbSNP
rs1239651615 1501 dbSNP
rs1372368813 1512 dbSNP
rs1023499427 1515 dbSNP
rs905104118 1516 dbSNP
rs1044029972 1522 dbSNP
rs1349813345 1523 dbSNP
rs1032268203 1524 dbSNP
rs1407458446 1533 dbSNP
rs575035246 1537 dbSNP
rs1366542637 1538 dbSNP
rs1163874708 1539 dbSNP
rs902534171 1540 dbSNP
rs1366155131 1543 dbSNP
rs999919495 1544 dbSNP
rs1029633839 1546 dbSNP
rs891227911 1547 dbSNP
rs1006890778 1555 dbSNP
rs1470143727 1560 dbSNP
rs1246070004 1569 dbSNP
rs542172121 1572 dbSNP
rs560708304 1573 dbSNP
rs1216232497 1576 dbSNP
rs543834220 1577 dbSNP
rs1203071051 1590 dbSNP
rs780861529 1595 dbSNP
rs868399430 1596 dbSNP
rs995796603 1598 dbSNP
rs1366937053 1604 dbSNP
rs1251189677 1610 dbSNP
rs1026303830 1612 dbSNP
rs1439186307 1613 dbSNP
rs951634960 1622 dbSNP
rs1346594995 1625 dbSNP
rs1030072842 1632 dbSNP
rs560239883 1632 dbSNP
rs879383551 1632 dbSNP
rs954520179 1642 dbSNP
rs1170796245 1643 dbSNP
rs1481367703 1643 dbSNP
rs1803425 1643 dbSNP
rs190436938 1646 dbSNP
rs1269412773 1674 dbSNP
rs1192671778 1675 dbSNP
rs868004184 1679 dbSNP
rs62207388 1680 dbSNP
rs1311720026 1684 dbSNP
rs1276565201 1686 dbSNP
rs990562631 1693 dbSNP
rs1225952868 1695 dbSNP
rs916454753 1701 dbSNP
rs920199182 1707 dbSNP
rs929962690 1711 dbSNP
rs1385352723 1712 dbSNP
rs531426127 1713 dbSNP
rs1430978688 1721 dbSNP
rs11544376 1722 dbSNP
rs1406555272 1726 dbSNP
rs562590282 1728 dbSNP
rs896564649 1733 dbSNP
rs1168248570 1734 dbSNP
rs1470630060 1740 dbSNP
rs775466205 1742 dbSNP
rs1045557883 1743 dbSNP
rs1462362338 1744 dbSNP
rs1476735830 1744 dbSNP
rs1333103046 1752 dbSNP
rs1187381502 1753 dbSNP
rs1421347716 1753 dbSNP
rs1483041738 1753 dbSNP
rs370489870 1754 dbSNP
rs1452147521 1763 dbSNP
rs374536127 1769 dbSNP
rs1461783843 1770 dbSNP
rs1032237028 1781 dbSNP
rs749081535 1783 dbSNP
rs183026590 1784 dbSNP
rs935237637 1789 dbSNP
rs1296720784 1792 dbSNP
rs1030041710 1793 dbSNP
rs1051047949 1800 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000398022.2 | 3UTR | AGAAGGAAGAUGGAAGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.374 3.6e-2 0.385 3.2e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.34 4.8e-2 0.216 1.5e-1 25 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.981 6.2e-2 1.000 5.0e-1 3 Click to see details
GSE19783 ER+ ER+ breast cancer -0.35 6.5e-2 -0.329 7.8e-2 20 Click to see details
GSE32688 Pancreatic cancer 0.258 7.7e-2 0.304 4.5e-2 32 Click to see details
GSE42095 Differentiated embryonic stem cells 0.251 1.2e-1 0.353 4.9e-2 23 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.239 1.2e-1 -0.055 4.0e-1 25 Click to see details
GSE19536 Breast cancer -0.106 1.5e-1 -0.265 3.9e-3 100 Click to see details
GSE17498 Multiple myeloma 0.135 2.0e-1 0.243 6.5e-2 40 Click to see details
GSE21032 Prostate cancer -0.089 2.1e-1 -0.051 3.2e-1 83 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.165 2.4e-1 0.153 2.6e-1 20 Click to see details
GSE21687 Ependynoma primary tumors 0.071 2.9e-1 0.068 3.0e-1 64 Click to see details
GSE19350 CNS germ cell tumors -0.139 3.3e-1 -0.299 1.7e-1 12 Click to see details
GSE19783 ER- ER- breast cancer -0.042 3.6e-1 -0.224 2.4e-2 79 Click to see details
GSE26953 Aortic valvular endothelial cells -0.079 3.6e-1 -0.172 2.1e-1 24 Click to see details
GSE28260 Renal cortex and medulla -0.063 4.2e-1 -0.044 4.4e-1 13 Click to see details
GSE38226 Liver fibrosis 0.032 4.5e-1 0.270 1.2e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
CESC 0.987 0.05 1.000 0.5 3 Click to see details
LIHC -0.211 0.07 -0.197 0.09 49 Click to see details
CHOL -0.525 0.07 -0.450 0.11 9 Click to see details
KIRP -0.249 0.08 -0.216 0.12 32 Click to see details
UCEC 0.311 0.1 0.323 0.09 19 Click to see details
KICH -0.243 0.12 -0.172 0.21 25 Click to see details
ESCA 0.375 0.13 0.391 0.12 11 Click to see details
BRCA 0.119 0.14 0.013 0.45 84 Click to see details
THCA 0.136 0.15 0.112 0.2 59 Click to see details
PCPG 0.873 0.16 1.000 0.5 3 Click to see details
LUAD -0.227 0.24 -0.315 0.16 12 Click to see details
PRAD -0.075 0.3 -0.067 0.32 50 Click to see details
PAAD -0.343 0.33 -0.800 0.1 4 Click to see details
COAD -0.176 0.34 -0.095 0.41 8 Click to see details
KIRC 0.043 0.36 0.052 0.34 68 Click to see details
STAD -0.063 0.37 -0.129 0.24 32 Click to see details
BLCA 0.072 0.39 0.135 0.3 18 Click to see details
HNSC 0.036 0.41 0.012 0.47 42 Click to see details
LUSC -0.005 0.49 -0.187 0.13 38 Click to see details
LUSC -0.005 0.49 -0.187 0.13 38 Click to see details
LUSC -0.005 0.49 -0.187 0.13 38 Click to see details
91 hsa-miR-125b-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038624 HN1L Jupiter microtubule associated homolog 2 1 1
MIRT038625 KDELC2 KDEL motif containing 2 1 1
MIRT038626 ABHD15 abhydrolase domain containing 15 1 1
MIRT038627 PPP1R12C protein phosphatase 1 regulatory subunit 12C 1 1
MIRT038628 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 1 1
MIRT038629 ASH2L ASH2 like histone lysine methyltransferase complex subunit 1 1
MIRT038630 USP22 ubiquitin specific peptidase 22 1 1
MIRT038631 CSTB cystatin B 1 1
MIRT038632 SYT2 synaptotagmin 2 1 1
MIRT038633 NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 1 1
MIRT038634 MTA2 metastasis associated 1 family member 2 1 1
MIRT053086 IGF1R insulin like growth factor 1 receptor 3 1
MIRT055788 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT061248 AMOTL1 angiomotin like 1 2 10
MIRT061649 BTG2 BTG anti-proliferation factor 2 2 6
MIRT079046 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT084583 BCL2L11 BCL2 like 11 2 8
MIRT093523 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 2
MIRT097383 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT098030 SOBP sine oculis binding protein homolog 2 2
MIRT186262 TCEB3 elongin A 2 2
MIRT187284 DAZAP2 DAZ associated protein 2 2 10
MIRT361113 LRRC1 leucine rich repeat containing 1 2 2
MIRT443585 FAM84B family with sequence similarity 84 member B 2 2
MIRT452249 TRAM1 translocation associated membrane protein 1 2 2
MIRT476289 GMFB glia maturation factor beta 2 8
MIRT483871 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT484250 ANK1 ankyrin 1 2 2
MIRT499251 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502270 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504652 RPL9 ribosomal protein L9 2 6
MIRT505210 UBN2 ubinuclein 2 2 6
MIRT512690 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT517341 ZNF529 zinc finger protein 529 2 4
MIRT518946 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520866 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521236 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT528324 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT533297 USP46 ubiquitin specific peptidase 46 2 2
MIRT541024 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT544034 ERRFI1 ERBB receptor feedback inhibitor 1 2 2
MIRT547037 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556102 MOAP1 modulator of apoptosis 1 2 2
MIRT558320 DR1 down-regulator of transcription 1 2 2
MIRT558520 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT566230 PTMA prothymosin, alpha 2 4
MIRT568437 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570584 OTUD7B OTU deubiquitinase 7B 2 2
MIRT571384 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572798 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573864 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT609930 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610437 CSMD2 CUB and Sushi multiple domains 2 2 2
MIRT614407 MURC caveolae associated protein 4 2 2
MIRT618625 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620605 SAP30 Sin3A associated protein 30 2 2
MIRT635313 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635918 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638507 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT640597 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT644066 IQCE IQ motif containing E 2 2
MIRT648287 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT653089 SSR3 signal sequence receptor subunit 3 2 2
MIRT654651 PTAFR platelet activating factor receptor 2 2
MIRT658084 FOXR2 forkhead box R2 2 2
MIRT665306 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665974 SYTL4 synaptotagmin like 4 2 2
MIRT674905 RASSF9 Ras association domain family member 9 2 2
MIRT680085 THAP1 THAP domain containing 1 2 2
MIRT681487 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691243 DFNB59 pejvakin 2 2
MIRT692361 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693034 MB21D1 Mab-21 domain containing 1 2 2
MIRT694478 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696069 ZNF264 zinc finger protein 264 2 2
MIRT696579 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696759 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697306 ZNF652 zinc finger protein 652 2 2
MIRT698736 STX12 syntaxin 12 2 2
MIRT701055 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701197 OTUD3 OTU deubiquitinase 3 2 2
MIRT701334 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT703617 FBXO45 F-box protein 45 2 2
MIRT708893 ZNF780A zinc finger protein 780A 2 2
MIRT711621 DGKH diacylglycerol kinase eta 2 2
MIRT713744 TMEM81 transmembrane protein 81 2 2
MIRT715060 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT719711 CD101 CD101 molecule 2 2
MIRT720293 DLGAP3 DLG associated protein 3 2 2
MIRT722605 CCDC152 coiled-coil domain containing 152 2 2
MIRT724565 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-125b-2 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-125b-2 Methotrexate 126941 NSC740 approved resistant High Colorectal Adenocarcinoma cell line (HT-29)
hsa-mir-125b-2 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia tissue
hsa-mir-125b-2 Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (Huh-7, HLE, HuH1)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-125b-2 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-125b-2 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-125b-2 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-125b-2 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved resistant tissue (ER-positive breast cancer)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Cyclophosphamide + Doxorubicin + Vincristine + Prednisone + Rituximab resistant High Diffuse Large B-Cell Lymphoma cell line (SU-DHL-2)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901, BGC-823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HCT8, HCT-116)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-125b-2-3p Antiepileptic Drug sensitive High Pediatric Epilepsy tissue
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-125b-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-125b-2-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-125b-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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