pre-miRNA Information
pre-miRNA hsa-mir-3622b   
Genomic Coordinates chr8: 27701673 - 27701767
Description Homo sapiens miR-3622b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3622b-3p
Sequence 58| UCACCUGAGCUCCCGUGCCUG |78
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1232922758 2 dbSNP
rs530939348 5 dbSNP
rs1439657384 10 dbSNP
rs1157333896 12 dbSNP
rs66683138 14 dbSNP
rs1044808718 15 dbSNP
rs946438979 19 dbSNP
rs551845360 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MIOX   
Synonyms ALDRL6
Description myo-inositol oxygenase
Transcript NM_017584   
Expression
Putative miRNA Targets on MIOX
3'UTR of MIOX
(miRNA target sites are highlighted)
>MIOX|NM_017584|3'UTR
   1 CCCTCCTGCCACCCAAGCTGCTGCTGGACCTAGGCCTGGCCCTCCGCCTGCCTGGAGAGGCCTGGCCCTGGGCAAACAGC
  81 CGCCATCAGGGTTCACCTCGGTGGGGGACCCCACTCACCCCCTTAGGGTCGCCACCCCTCACGGCAACTTGTGCCTGGCG
 161 TCAATAAAGACCTGGAAGGATGTTGTGCTTCTGAAGCCCCACTGGGTGTTACTGCAGCAGGGCGTGGCCCAGGCCGAGGG
 241 ATGGTGCCAGCAGGGTGGAGGCCAAGTCCCAGGCTTTCAGGTGTGTGTGTCCCACCACACTGGCCGTGGTAAACATCTGC
 321 CCATCCTCCCAGCTCCTGTGTCAGAGCCTGGGGGACGAGTCACCCAGCTCACCCCCACATGCTCAAAACAGTCACCAAGT
 401 CCTCTGGGCTCCGTCCCCTTAAAAAATACCCCAATAGCTAAAATAATACATTCATAGAAAACAAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guCCGUGCCCUCGAGUCCACu 5'
            | | | ||  :||||||| 
Target 5' aaGTCCCAGGCTTTCAGGTGt 3'
264 - 284 151.00 -17.00
2
miRNA  3' guCCG--UGCCCUCG--AGUCCacu 5'
            |||  || |  ||  |||||   
Target 5' tgGGCAAACAGCCGCCATCAGGgtt 3'
69 - 93 111.00 -12.00
3
miRNA  3' guCCGUGCC-C--UCGAGU-CCACu 5'
            || |:|| |  ||  || |||| 
Target 5' gaGGGATGGTGCCAG--CAGGGTGg 3'
236 - 258 92.00 -18.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30521339 9 COSMIC
COSN30448324 34 COSMIC
COSN30448427 35 COSMIC
COSN31603059 46 COSMIC
COSN28627662 56 COSMIC
COSN30151973 62 COSMIC
COSN30192136 95 COSMIC
COSN28839604 127 COSMIC
COSN1901557 154 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1206271533 2 dbSNP
rs763323405 5 dbSNP
rs766798331 9 dbSNP
rs1365409739 11 dbSNP
rs1454426796 15 dbSNP
rs769888953 17 dbSNP
rs1400392678 18 dbSNP
rs1454800932 26 dbSNP
rs190239688 27 dbSNP
rs202149960 28 dbSNP
rs767910582 32 dbSNP
rs374823235 34 dbSNP
rs746258473 36 dbSNP
rs764246158 37 dbSNP
rs548851323 38 dbSNP
rs750396099 40 dbSNP
rs1342202595 43 dbSNP
rs775735699 44 dbSNP
rs566911453 46 dbSNP
rs2232887 47 dbSNP
rs1457165527 48 dbSNP
rs1176532918 51 dbSNP
rs762979093 52 dbSNP
rs1419389291 55 dbSNP
rs1055271 56 dbSNP
rs1055272 58 dbSNP
rs113284967 68 dbSNP
rs1177933210 71 dbSNP
rs1469808417 79 dbSNP
rs749701017 81 dbSNP
rs1041918654 82 dbSNP
rs1047333478 83 dbSNP
rs1259126013 84 dbSNP
rs2232888 88 dbSNP
rs1336687723 92 dbSNP
rs1346677214 97 dbSNP
rs1439312650 99 dbSNP
rs538981699 100 dbSNP
rs554304958 101 dbSNP
rs1033995533 107 dbSNP
rs182125529 114 dbSNP
rs995860392 122 dbSNP
rs140205443 127 dbSNP
rs769192470 128 dbSNP
rs1227943370 129 dbSNP
rs150334058 131 dbSNP
rs555142499 132 dbSNP
rs1446452663 135 dbSNP
rs2232889 135 dbSNP
rs1259783987 138 dbSNP
rs543867386 139 dbSNP
rs1354748510 142 dbSNP
rs761279314 143 dbSNP
rs186814945 144 dbSNP
rs111747919 146 dbSNP
rs1202301732 150 dbSNP
rs1382427507 153 dbSNP
rs911457644 158 dbSNP
rs368192822 159 dbSNP
rs1064043 160 dbSNP
rs1436294149 161 dbSNP
rs1395483581 165 dbSNP
rs1167220679 167 dbSNP
rs1471981740 175 dbSNP
rs1474410145 181 dbSNP
rs1179519659 182 dbSNP
rs1371385490 190 dbSNP
rs1038370630 192 dbSNP
rs1195489351 193 dbSNP
rs1400972847 195 dbSNP
rs920062263 199 dbSNP
rs1256996280 201 dbSNP
rs917477207 202 dbSNP
rs1486828296 203 dbSNP
rs1279817343 207 dbSNP
rs1214460035 208 dbSNP
rs971696646 213 dbSNP
rs944842801 214 dbSNP
rs953898612 219 dbSNP
rs1354287378 222 dbSNP
rs1291006116 223 dbSNP
rs138007121 225 dbSNP
rs1375806315 228 dbSNP
rs192342475 229 dbSNP
rs1408126985 231 dbSNP
rs1168429367 233 dbSNP
rs183904121 233 dbSNP
rs915013552 236 dbSNP
rs931610450 237 dbSNP
rs1476331199 239 dbSNP
rs1050124982 240 dbSNP
rs1204351585 256 dbSNP
rs1409307016 263 dbSNP
rs907007200 267 dbSNP
rs143666145 271 dbSNP
rs1275658125 274 dbSNP
rs944676433 278 dbSNP
rs11705365 281 dbSNP
rs780407811 290 dbSNP
rs1234726677 297 dbSNP
rs1040966142 300 dbSNP
rs994631883 301 dbSNP
rs1027670652 306 dbSNP
rs1055666869 307 dbSNP
rs1312443433 309 dbSNP
rs560291906 312 dbSNP
rs894389160 316 dbSNP
rs572184938 326 dbSNP
rs34472885 327 dbSNP
rs1460882179 333 dbSNP
rs117099296 335 dbSNP
rs967163192 339 dbSNP
rs1463209760 353 dbSNP
rs1293181576 355 dbSNP
rs188553057 357 dbSNP
rs760547811 358 dbSNP
rs955751922 361 dbSNP
rs11705385 368 dbSNP
rs986950680 374 dbSNP
rs1202383228 380 dbSNP
rs531326364 385 dbSNP
rs1468465701 387 dbSNP
rs1270716445 390 dbSNP
rs1215093032 395 dbSNP
rs972051795 396 dbSNP
rs1234180257 397 dbSNP
rs1470300479 403 dbSNP
rs1180936375 406 dbSNP
rs1411275270 408 dbSNP
rs1446254250 413 dbSNP
rs549334445 414 dbSNP
rs564551153 415 dbSNP
rs1327850367 421 dbSNP
rs375501323 423 dbSNP
rs1158611146 427 dbSNP
rs1326933918 429 dbSNP
rs1399217367 430 dbSNP
rs1416761470 435 dbSNP
rs547825199 436 dbSNP
rs1356415538 444 dbSNP
rs1251604137 445 dbSNP
rs192934949 453 dbSNP
rs1241048754 454 dbSNP
rs919886029 454 dbSNP
rs536480956 456 dbSNP
rs986195249 457 dbSNP
rs1286450118 459 dbSNP
rs1233212926 466 dbSNP
rs911595932 468 dbSNP
rs147183980 474 dbSNP
rs1036197691 479 dbSNP
rs1368357605 480 dbSNP
rs1288416257 482 dbSNP
rs928724568 483 dbSNP
rs570138865 486 dbSNP
rs897763589 488 dbSNP
rs185438473 493 dbSNP
rs558944212 494 dbSNP
rs577214368 496 dbSNP
rs947275363 505 dbSNP
rs1042744967 510 dbSNP
rs1434288767 511 dbSNP
rs1418133430 513 dbSNP
rs902825926 514 dbSNP
rs538915633 517 dbSNP
rs998511863 521 dbSNP
rs1274425938 524 dbSNP
rs553813836 527 dbSNP
rs1437907623 528 dbSNP
rs572182265 529 dbSNP
rs1210700678 531 dbSNP
rs1030522888 535 dbSNP
rs890199489 536 dbSNP
rs1008437812 537 dbSNP
rs542383535 538 dbSNP
rs1342464233 545 dbSNP
rs1279018215 552 dbSNP
rs1235403321 556 dbSNP
rs1024821393 557 dbSNP
rs1305007080 560 dbSNP
rs771128123 571 dbSNP
rs1466989871 579 dbSNP
rs907164518 580 dbSNP
rs964296971 585 dbSNP
rs1168955706 588 dbSNP
rs543928738 591 dbSNP
rs56235139 592 dbSNP
rs1186748424 596 dbSNP
rs1031901193 597 dbSNP
rs575693570 600 dbSNP
rs188600738 608 dbSNP
rs34404629 617 dbSNP
rs564538928 619 dbSNP
rs759461731 620 dbSNP
rs1410635753 621 dbSNP
rs765237469 623 dbSNP
rs1404155994 624 dbSNP
rs1454819014 628 dbSNP
rs112478467 630 dbSNP
rs1232872081 630 dbSNP
rs1315263986 631 dbSNP
rs1353859131 631 dbSNP
rs1396903819 632 dbSNP
rs1011731950 633 dbSNP
rs1467683634 634 dbSNP
rs938730412 635 dbSNP
rs374862851 636 dbSNP
rs1364940798 637 dbSNP
rs1429153050 638 dbSNP
rs991291392 639 dbSNP
rs1272460811 643 dbSNP
rs915719391 645 dbSNP
rs1218105750 647 dbSNP
rs1418236510 650 dbSNP
rs1260748337 652 dbSNP
rs1248185767 654 dbSNP
rs751741283 661 dbSNP
rs561195596 664 dbSNP
rs1238847531 667 dbSNP
rs1247123817 668 dbSNP
rs903085058 678 dbSNP
rs934354407 686 dbSNP
rs759578352 687 dbSNP
rs548055427 688 dbSNP
rs1477685340 693 dbSNP
rs1305380010 694 dbSNP
rs201431076 694 dbSNP
rs1378380948 695 dbSNP
rs1190654421 697 dbSNP
rs971715944 702 dbSNP
rs890211543 703 dbSNP
rs1471045355 704 dbSNP
rs559824462 705 dbSNP
rs1007281376 708 dbSNP
rs1160292763 709 dbSNP
rs8140686 710 dbSNP
rs1394328294 711 dbSNP
rs1191681808 719 dbSNP
rs915715013 734 dbSNP
rs549810428 738 dbSNP
rs1399341780 740 dbSNP
rs948564478 744 dbSNP
rs899977514 745 dbSNP
rs191951538 747 dbSNP
rs995677361 749 dbSNP
rs1045794997 761 dbSNP
rs1354886390 763 dbSNP
rs61639539 763 dbSNP
rs796737370 763 dbSNP
rs907295113 763 dbSNP
rs1027683955 768 dbSNP
rs1323696470 770 dbSNP
rs1381286265 771 dbSNP
rs893387842 771 dbSNP
rs1011867507 772 dbSNP
rs1420021069 772 dbSNP
rs951660755 772 dbSNP
rs1029000471 774 dbSNP
rs1478996768 777 dbSNP
rs1199762761 786 dbSNP
rs183755373 786 dbSNP
rs1428004192 787 dbSNP
rs1261232412 789 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' guccgugcccucgAGUCCACu 5'
                       ||||||| 
Target 5' -------------UCAGGUGu 3'
1 - 8
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000395732.3 | 3UTR | UCAGGUGUGUGUGUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.004 0.5 0.107 0.41 7 Click to see details
THCA -0.004 0.5 0.107 0.41 7 Click to see details
THCA -0.004 0.5 0.107 0.41 7 Click to see details
THCA -0.004 0.5 0.107 0.41 7 Click to see details
THCA -0.004 0.5 0.107 0.41 7 Click to see details
THCA -0.004 0.5 0.107 0.41 7 Click to see details
102 hsa-miR-3622b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT076713 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT080212 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT081398 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT107158 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT254071 BACH1 BTB domain and CNC homolog 1 2 2
MIRT409790 FOXO3 forkhead box O3 2 2
MIRT448679 MAPK9 mitogen-activated protein kinase 9 2 2
MIRT450206 ABHD15 abhydrolase domain containing 15 2 2
MIRT486621 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT489267 TTLL1 tubulin tyrosine ligase like 1 2 2
MIRT493117 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 4
MIRT494570 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497395 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT504900 CCDC86 coiled-coil domain containing 86 2 2
MIRT505192 USP46 ubiquitin specific peptidase 46 2 4
MIRT506522 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT508162 ABCC5 ATP binding cassette subfamily C member 5 2 8
MIRT508545 PARVG parvin gamma 2 4
MIRT509850 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT510088 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 8
MIRT512094 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT515381 RPL7 ribosomal protein L7 2 2
MIRT519176 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519964 ZCCHC8 zinc finger CCHC-type containing 8 2 2
MIRT522292 NKAP NFKB activating protein 2 2
MIRT523160 HMGB2 high mobility group box 2 2 4
MIRT525314 FANCA Fanconi anemia complementation group A 2 2
MIRT528194 PLEKHM2 pleckstrin homology and RUN domain containing M2 2 2
MIRT532885 ZNF451 zinc finger protein 451 2 2
MIRT538209 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT539497 ACTN4 actinin alpha 4 2 2
MIRT554600 RRAGC Ras related GTP binding C 2 2
MIRT562444 DCTN6 dynactin subunit 6 2 2
MIRT562748 AOC3 amine oxidase, copper containing 3 2 2
MIRT565798 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT565838 SCML2 Scm polycomb group protein like 2 2 2
MIRT566072 RCC2 regulator of chromosome condensation 2 2 2
MIRT566104 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT572407 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT576198 Vsig2 V-set and immunoglobulin domain containing 2 2 2
MIRT576313 Acbd7 acyl-Coenzyme A binding domain containing 7 2 2
MIRT576651 Mill2 MHC I like leukocyte 2 1 1
MIRT576859 Socs6 suppressor of cytokine signaling 6 2 2
MIRT606819 BICD2 BICD cargo adaptor 2 2 2
MIRT610738 NUDT16 nudix hydrolase 16 2 4
MIRT614798 RORA RAR related orphan receptor A 2 2
MIRT619006 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 2
MIRT619420 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT620405 MYO1H myosin IH 2 2
MIRT624869 ABHD13 abhydrolase domain containing 13 2 2
MIRT633527 ZFP30 ZFP30 zinc finger protein 2 2
MIRT633927 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT636611 CLIC5 chloride intracellular channel 5 2 2
MIRT640616 MIOX myo-inositol oxygenase 2 2
MIRT642605 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT644624 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT655113 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT658976 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT661495 CHMP1B charged multivesicular body protein 1B 2 2
MIRT662996 TMEM59 transmembrane protein 59 2 2
MIRT663075 SFR1 SWI5 dependent homologous recombination repair protein 1 2 2
MIRT665405 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT666106 SSR1 signal sequence receptor subunit 1 2 2
MIRT669562 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT670070 ZNF783 zinc finger family member 783 2 2
MIRT671192 ZNF891 zinc finger protein 891 2 2
MIRT675361 KLHL26 kelch like family member 26 2 2
MIRT678857 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT679443 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT684163 ALDH1B1 aldehyde dehydrogenase 1 family member B1 2 2
MIRT684543 ZNF460 zinc finger protein 460 2 2
MIRT684674 SLC2A11 solute carrier family 2 member 11 2 2
MIRT684971 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT686006 NEK4 NIMA related kinase 4 2 2
MIRT687758 KIAA1328 KIAA1328 2 2
MIRT688961 ATXN3 ataxin 3 2 2
MIRT689409 UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2 2
MIRT690001 MMP17 matrix metallopeptidase 17 2 2
MIRT690165 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT690202 C5orf45 MRN complex interacting protein 2 2
MIRT690477 ZNF33A zinc finger protein 33A 2 2
MIRT690566 MICA MHC class I polypeptide-related sequence A 2 2
MIRT692160 C10orf111 chromosome 10 open reading frame 111 2 2
MIRT693430 PLGLB2 plasminogen-like B2 2 2
MIRT693547 ZNF708 zinc finger protein 708 2 2
MIRT693697 PLGLB1 plasminogen-like B1 2 2
MIRT695006 HSPA6 heat shock protein family A (Hsp70) member 6 2 2
MIRT698525 TFRC transferrin receptor 2 2
MIRT699574 SIKE1 suppressor of IKBKE 1 2 2
MIRT703446 FYTTD1 forty-two-three domain containing 1 2 2
MIRT704397 CTSS cathepsin S 2 2
MIRT704485 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT709822 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT710859 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT711893 INSIG2 insulin induced gene 2 2 2
MIRT713796 CPLX2 complexin 2 2 2
MIRT718800 C1GALT1C1 C1GALT1 specific chaperone 1 2 2
MIRT719501 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719722 PDE6B phosphodiesterase 6B 2 2
MIRT722204 URM1 ubiquitin related modifier 1 2 2
MIRT723523 CLPTM1L CLPTM1 like 2 2
MIRT725471 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3622b-3p Platinum 23939 sensitive tissue
hsa-miR-3622b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3622b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3622b-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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