pre-miRNA Information
pre-miRNA hsa-mir-4708   
Genomic Coordinates chr14: 65335117 - 65335183
Description Homo sapiens miR-4708 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4708-5p
Sequence 9| AGAGAUGCCGCCUUGCUCCUU |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1017378847 9 dbSNP
rs750825813 10 dbSNP
rs1297395738 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SCN2B   
Synonyms ATFB14
Description sodium voltage-gated channel beta subunit 2
Transcript NM_004588   
Expression
Putative miRNA Targets on SCN2B
3'UTR of SCN2B
(miRNA target sites are highlighted)
>SCN2B|NM_004588|3'UTR
   1 TGGGTGGCCGGCCCTGCAGCCTCCCGTGTCCCGTCTCCTCCCCTCTCCGCCCTGTACAGTGACCCTGCCTGCTCGCTCTT
  81 GGTGTGCTTCCCGTGACCTAGGACCCCAGGGCCCACCTGGGGCCTCCTGAACCCCCGACTTCGTATCTCCCACCCTGCAC
 161 CAAGAGTGACCCACTCTCTTCCATCCGAGAAACCTGCCATGCTCTGGGACGTGTGGGCCCTGGGGAGAGGAGAGAAAGGG
 241 CTCCCACCTGCCAGTCCCTGGGGGGAGGCAGGAGGCACATGTGAGGGTCCCCAGAGAGAAGGGAGTGGGTGGGCAGGGGT
 321 AGAGGAGGGGGCCGCTGTCCACCTGCCCAGTGCTTGGCCTGGCAGTGGCTTCAGAGAGGACCTGGTGGGGAGGGAGGGCT
 401 TTCCTGTGCTGACAGCGCTCCCTCAGGAGGGCCTTGGCCTGGCACGGCTGTGCTCCTCCCCTGCTCCCAGCCCAGAGCAG
 481 CCATCAGGCTGGAGGTGACGATGAGTTCCTGAAACTTGGAGGGGCATGTTAAAGGGATGACTGTGCATTCCAGGGCACTG
 561 ACGGAAAGCCAGGGCTGCAGGCAAAGCTGGACATGTGCCCTGGCCCAGGAGGCCATGTTGGGCCCTCGTTTCCATTGCTA
 641 GTGGCCTCCTTGGGGCTCCCGTTGGCTCCTAATCCCTTAGGACTGTGGATGAGGCCAGACTGGAAGAGCAGCTCCAGGTA
 721 GGGGGCCATGTTTCCCAGCGGGGACCCACCAACAGAGGCCAGTTTCAAAGTCAGCTGAGGGGCTGAGGGGTGGGGCTCCA
 801 TGGTGAATGCAGGTTGCTGCAGGCTCTGCCTTCTCCATGGGGTAACCACCCTCGCCTGGGCAGGGGCAGCCAAGGCTGGG
 881 AAATGAGGAGGCCATGCACAGGGTGGGGCAGCTTTCTTTGGGGCTTCAGTGAGAACTCTCCCAGTTGCCCTTGGTGGGGT
 961 TTCCACCTGGCTTTTGGCTACAGAGAGGGAAGGGAAAGCCTGAGGCCGGCATAAGGGGAGGCCTTGGAACCTGAGCTGCC
1041 AATGCCAGCCCTGTCCCATCTGCAGCCACACTACTCGCTCCTCTCCCAACAACTCCCTTCGTGGGGACAAAAGTGACAAT
1121 TGTAGGCCAGGCACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATTACCTCCATCTGTTT
1201 AGTAGAAATGGGCAAAACCCCATCTCTACTAAAAATACAAGAATTAGCTGGGCGTGGTGGCGTGTGCCTGTAATCCCAGC
1281 TATTTGGGAGGCTGAGGCAGGAGAATCGCTTGAGCCCGGGAAGCAGAGGTTGCAGTGAACTGAGATAGTGATAGTGCCAC
1361 TGCAATTCAGCCTGGGTGACATAGAGAGACTCCATCTCAAAAAAAAAAAAAAAAAAAAAAAAAGGCAATTGTGCGGAGCC
1441 AACCATCACTGCCATTACACTCACATTCAATGGAAATTGATTAGGCCTGAGAGAAGGAGCAAGAGGCAGAAACACTGACT
1521 CTGAGACCATGACCTTGGAAGATCCTCAGAGATCAACTAGCCAAGTCACTCACTTAAAATGGGGAAACTGAGGTTCCAAC
1601 TGACAGAAACTGAGGGTCCTGCCCTCTTCTCTGGCTCCTCAGTCTCCAGTTTGAAGCAACAGAGCCATCATTTTCCCAGT
1681 GGGAGGGGCCTCTGTGTCCTGGTCTATGATGGGGCGAGTTGGAGGGGTGGGCTTCTCTAGCCCTGCCCCCTCCCAGGAGC
1761 CCAGCCCCTCTGGCCAGGACTGAGGAGGAGTGGAGGGAAGCAGGGAGGGAGGGAGCAAGTGTGAAGGGCACAGCTGCTGG
1841 CAAATGCCCCATTCCCTGCCCCAGCACTTCCCAGCCTTTCCAGGAGCTCTGCCCCACCCCTACTCAAGGAGTCAGGTGCC
1921 CAGGGTAGGGAATAAGTCTAGGAAAGGGGGTGGAGACAGGACCGTGACAGTCTCAGGGACCAATCCCTGCCTCTGCCCAT
2001 CAGATTGCCAATTTGGGGAGACAGCAATATCATCTGGGAGATTCAGCTTAATTTGCTTCAATTCAGCAACCATTTATTGA
2081 GCATCTATTATGTGCCAGGCACTGTGCCGGGCACTGGGGATATACACAAAGCCATAAGCACTGGGGACTGCCAGGTTGGC
2161 ACTGTAGGGACCAAGATTAACTTTTTGGTGCATCTAATTCCACCTCTGCAAGACACTGCTTCCAAGGCTACAGTTGGGGA
2241 AGATGAAGAGATTCTAGAATCTGTGCCCTGGGAAGGGAGAAACAGCAGGGAAGAGGGGCAATACAACAGGGTCAAGGGTG
2321 CAGAGGCCAGGCAGAGTGGGTGCAGAGTGGGGGATGGGCAACCAGCCTGGTAACACCTGGGTGAGGTGAGCGAGTCAAGC
2401 CCATCTGGAAATGCTAAACTCATCAGCTCAGTACCTAACTGCCAATCAACACACTGCCAATGCGGGTGGGCTAAGCCGCC
2481 AGGATGCCTGCAGCAGATGGACGCTGCCCATCCTTGAGCCAGCCAGCTGGGGGCAGAGAGGTGGGTGGCGGGCACCTCAT
2561 GCCAGCTGAGACCAAGAGTGGTTGTATACATTTCTGCAGCTTGCAGATTTCATTTTTTTGGTCACCCTTTAAGTGTCCTT
2641 CTCTCCCAGGATGAGTGAGGAGCTGTGCTGATGTTGGGAACTTATCTTTTTCCAGGATCCATAACATTTAGGGGAATTAT
2721 TTGCGGGCTTTCCTAGTGTATTCTAAGAAGTTCTAACTCTCCATCAAGAAGCCCAAGATTCCTGGAGTCTTTTTTTCCTC
2801 TGCCCTGATCAACTGGGGCCCAGGAAAAGCAATGTCTCTTCACGGGCCTCAGGGCCCCAGCAGATGGGGCTGGGTCAGGA
2881 ACCATCTCTGTCCCAGGTGCTCAGCCCTCATATGCATTTTCTTCTGGAGCCTCTTAGAATCTCCTCCAGAGGACTCATAG
2961 AGCTGCCTCCCCCAGGATGGTGAAGTTGGGAGCAAAATGGGGCTTCTGTAAGTAGAGGTGGAAAACCAGAGAGATGTTTC
3041 CACAGCAGCCATTTCCCTACCCTGTTTCCTAACTTATGCTGACAAGTTCTTCCTCTTCCTACCGTGGGGTTCGAGCCCCA
3121 CTTCTGGTTGCATGTTCCCACCACCACGCTCTGCTGGTTTTAGTCGGCTGACTTTCTCAACTGCCCCAGCCTCTCCTGCT
3201 CTCTCAGAACCTCCCTCTGCCCCCACCCCCCATCTGTCTCTTCCTCCTAATTAAGGGCCACTGCAAAGAGAGACGGGCTG
3281 GCTAACCCATGGGATTTAGCTTATAAGAACAAAGCACAATTATTCAGGACTGAACTGCTTTGAGGTGCCTTGGAACTGGC
3361 TTTGGAAATAGCTATCTGCCCCCTAGCTATGGACTCTTCACAGTTATTTCCAGTTTATAAAAAGGAAAAGCTGATCGGAT
3441 CCATGTTTCTCTCTGCGAGTCTCCTTGGGGAGGTTGGGCTGGTAAATATTTGCAAGGTCAGGTTAAGCAGACAGACAATT
3521 GAAAATACTGGGCAGGTCCAAAAGGATAGTTCCAGGCCATAGGAATGGCTTGGTGCAGTTAACGGGTGATGAAGCAAGAA
3601 ATCTTCCTTCCTACTTATGTCTTAAAGATGGACAGCCTGTGTCTCTTGCTGTGCCTCTTGCTGGCGTCTTCCTTTATTGA
3681 AGCTTGCTGATGCACTGTACATAGTCTCTCTCTCTAGGTATAGATATATTATATATACAAATATCAAACATCTCACCACA
3761 CCCACCCCAAAAGTTACACTGTGTGTGTGTGGGGAGGTGTAATAACTTCTCAGTGTTTTGAGTTGATTCACCAAAGGCAA
3841 ATTTTGGAATGTTCTTGCGCTTTGTGCACTTGGAGGGGAAAACCCAACTACATATGCACTTTCTTGGTTGTGTGTGCTAT
3921 AGAGAGGTTGGAAGGGGTGGTTGGAAGGGGAGAGAAACTGAGATGGCCCTCTGTGACTCGACTGCTGGGATGTATCTGCT
4001 TTTGGGAGCAGACTGAGTTTCTTTTGCAATTTGTCTTATTGTTTGGGTCTACTGGCAACAATAAACTATCTCCCCTGAAA
4081 ATC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uucCUCGUUCCGCCGUAGAGa 5'
             |:||||  |  |||||| 
Target 5' aatGGGCAAAACCCCATCTCt 3'
1207 - 1227 130.00 -13.60
2
miRNA  3' uuccucGUUCCGCCGUAGAGa 5'
                |:|  : |:||||| 
Target 5' aaccccCGACTTCGTATCTCc 3'
130 - 150 127.00 -7.00
3
miRNA  3' uuCCUCGUUCCG-CCGUAGAGa 5'
            ||||  :||: ||| |||| 
Target 5' ttGGAG--GGGTGGGCTTCTCt 3'
1719 - 1738 127.00 -18.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26993928 10 COSMIC
COSN30469967 30 COSMIC
COSN13303848 33 COSMIC
COSN18735963 38 COSMIC
COSN31613529 48 COSMIC
COSN31578452 75 COSMIC
COSN32052194 79 COSMIC
COSN30446998 90 COSMIC
COSN30456196 92 COSMIC
COSN1127322 126 COSMIC
COSN19673989 136 COSMIC
COSN26749485 136 COSMIC
COSN31550051 170 COSMIC
COSN5257200 171 COSMIC
COSN30159905 178 COSMIC
COSN1127321 258 COSMIC
COSN22612558 518 COSMIC
COSN16490697 822 COSMIC
COSN26510922 878 COSMIC
COSN17183429 1145 COSMIC
COSN23934757 1398 COSMIC
COSN26579521 1418 COSMIC
COSN31524337 1487 COSMIC
COSN29307329 1516 COSMIC
COSN28634128 1732 COSMIC
COSN31563046 1803 COSMIC
COSN1515729 1816 COSMIC
COSN31608738 1887 COSMIC
COSN21677457 1938 COSMIC
COSN8734027 2429 COSMIC
COSN31555031 2461 COSMIC
COSN6988103 2464 COSMIC
COSN28579924 2502 COSMIC
COSN17443080 2515 COSMIC
COSN17444250 2516 COSMIC
COSN32134713 2753 COSMIC
COSN5257198 2889 COSMIC
COSN28078098 2960 COSMIC
COSN31564858 3148 COSMIC
COSN20108806 3168 COSMIC
COSN24304113 3281 COSMIC
COSN32057898 3401 COSMIC
COSN30539531 3411 COSMIC
COSN31532458 3441 COSMIC
COSN31514043 3457 COSMIC
COSN30544307 3519 COSMIC
COSN30542808 3545 COSMIC
COSN31540745 3571 COSMIC
COSN31544830 3859 COSMIC
COSN26670034 3874 COSMIC
COSN8734026 4062 COSMIC
rs677652 891 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs201185240 2 dbSNP
rs1465873285 3 dbSNP
rs776350272 5 dbSNP
rs1357240858 6 dbSNP
rs768499780 8 dbSNP
rs759635029 9 dbSNP
rs749428739 10 dbSNP
rs757583950 15 dbSNP
rs375956302 16 dbSNP
rs1317460773 17 dbSNP
rs1219487670 19 dbSNP
rs561204712 22 dbSNP
rs75535056 25 dbSNP
rs368267712 26 dbSNP
rs541373583 27 dbSNP
rs1438171097 32 dbSNP
rs202025244 33 dbSNP
rs779796644 34 dbSNP
rs930898530 35 dbSNP
rs1482663468 37 dbSNP
rs8192614 38 dbSNP
rs777341561 44 dbSNP
rs749991669 45 dbSNP
rs374338920 48 dbSNP
rs761669518 49 dbSNP
rs960859658 58 dbSNP
rs1377180592 59 dbSNP
rs1350926257 60 dbSNP
rs1417801994 64 dbSNP
rs1035134304 66 dbSNP
rs545559368 69 dbSNP
rs1240511856 71 dbSNP
rs1330080721 72 dbSNP
rs978188950 75 dbSNP
rs763201974 76 dbSNP
rs576845981 79 dbSNP
rs1388843320 84 dbSNP
rs940336530 87 dbSNP
rs1279855479 88 dbSNP
rs966754399 92 dbSNP
rs754072592 93 dbSNP
rs984526509 97 dbSNP
rs764362958 102 dbSNP
rs773980611 104 dbSNP
rs1194741437 105 dbSNP
rs1244616208 108 dbSNP
rs542359426 110 dbSNP
rs1034533100 112 dbSNP
rs1396667211 113 dbSNP
rs1437705138 115 dbSNP
rs979930768 132 dbSNP
rs1288841391 134 dbSNP
rs971644599 136 dbSNP
rs1320451376 137 dbSNP
rs370061828 140 dbSNP
rs1436049680 142 dbSNP
rs1024185033 143 dbSNP
rs1309131014 165 dbSNP
rs1352116128 171 dbSNP
rs1206367316 172 dbSNP
rs1434348285 176 dbSNP
rs1010147281 182 dbSNP
rs892457518 186 dbSNP
rs200598418 187 dbSNP
rs995993987 192 dbSNP
rs1480979925 193 dbSNP
rs574689591 194 dbSNP
rs1434728353 195 dbSNP
rs554898386 202 dbSNP
rs1411729330 203 dbSNP
rs1192932048 209 dbSNP
rs1000841974 210 dbSNP
rs182045375 211 dbSNP
rs1216629623 215 dbSNP
rs901666858 224 dbSNP
rs1241812307 227 dbSNP
rs1281883888 234 dbSNP
rs199692185 242 dbSNP
rs769999326 243 dbSNP
rs1050952065 245 dbSNP
rs1044302844 246 dbSNP
rs1253848094 257 dbSNP
rs8192615 259 dbSNP
rs902049258 262 dbSNP
rs1277954333 263 dbSNP
rs1238579587 267 dbSNP
rs1040160702 272 dbSNP
rs534954852 280 dbSNP
rs1342866866 285 dbSNP
rs565917142 286 dbSNP
rs886156258 290 dbSNP
rs1400115774 291 dbSNP
rs1420272010 292 dbSNP
rs1464272627 304 dbSNP
rs1170326477 305 dbSNP
rs1174583303 314 dbSNP
rs1397695015 316 dbSNP
rs940951142 322 dbSNP
rs907519988 325 dbSNP
rs376735133 327 dbSNP
rs930326475 327 dbSNP
rs1340444124 328 dbSNP
rs558935531 331 dbSNP
rs1414863403 333 dbSNP
rs146529636 334 dbSNP
rs916853940 336 dbSNP
rs1169613557 341 dbSNP
rs991059704 347 dbSNP
rs1251637869 350 dbSNP
rs1341241427 353 dbSNP
rs775673527 362 dbSNP
rs1277820866 364 dbSNP
rs930308957 373 dbSNP
rs1188673320 377 dbSNP
rs1259705990 381 dbSNP
rs1193245450 382 dbSNP
rs1373904294 387 dbSNP
rs927027139 392 dbSNP
rs1171262045 397 dbSNP
rs1193795677 399 dbSNP
rs978218581 402 dbSNP
rs1435902211 403 dbSNP
rs1441383243 404 dbSNP
rs1253440404 406 dbSNP
rs966784609 409 dbSNP
rs556609833 416 dbSNP
rs570099887 417 dbSNP
rs980260638 432 dbSNP
rs748284856 438 dbSNP
rs1230771595 441 dbSNP
rs75595194 445 dbSNP
rs1212973611 446 dbSNP
rs1282501674 449 dbSNP
rs1487336541 450 dbSNP
rs1204671894 455 dbSNP
rs530185443 456 dbSNP
rs917103058 459 dbSNP
rs996069111 460 dbSNP
rs988673328 471 dbSNP
rs955977548 475 dbSNP
rs965906452 477 dbSNP
rs567562554 478 dbSNP
rs1018741102 479 dbSNP
rs781188799 482 dbSNP
rs1418553015 484 dbSNP
rs1032906267 485 dbSNP
rs1384718772 497 dbSNP
rs879208942 499 dbSNP
rs772157940 500 dbSNP
rs1236283315 515 dbSNP
rs144139876 524 dbSNP
rs1238406129 542 dbSNP
rs1261402289 543 dbSNP
rs1338835940 545 dbSNP
rs886229156 551 dbSNP
rs528016753 553 dbSNP
rs1469174305 554 dbSNP
rs1195962822 555 dbSNP
rs528868573 562 dbSNP
rs113739057 563 dbSNP
rs1330456353 574 dbSNP
rs1159108856 593 dbSNP
rs774317384 598 dbSNP
rs1463833191 600 dbSNP
rs79410537 609 dbSNP
rs532022020 612 dbSNP
rs886662137 617 dbSNP
rs1329128969 618 dbSNP
rs1375970793 621 dbSNP
rs1224283717 627 dbSNP
rs1307728966 628 dbSNP
rs563327535 641 dbSNP
rs1335819697 643 dbSNP
rs543587004 650 dbSNP
rs926988822 653 dbSNP
rs1480565777 655 dbSNP
rs1188947315 658 dbSNP
rs676685 660 dbSNP
rs868129612 661 dbSNP
rs949865080 663 dbSNP
rs1196330573 684 dbSNP
rs1459406539 690 dbSNP
rs945556980 691 dbSNP
rs915339290 693 dbSNP
rs989560871 702 dbSNP
rs954247425 711 dbSNP
rs1442781049 723 dbSNP
rs1469979658 726 dbSNP
rs917060203 727 dbSNP
rs1228318836 736 dbSNP
rs1394364948 739 dbSNP
rs1292758528 740 dbSNP
rs677105 741 dbSNP
rs1356275815 750 dbSNP
rs1235398506 751 dbSNP
rs1256518744 758 dbSNP
rs749099033 759 dbSNP
rs921289253 763 dbSNP
rs1286043006 777 dbSNP
rs988576927 781 dbSNP
rs117145614 782 dbSNP
rs1253583239 784 dbSNP
rs1482601018 789 dbSNP
rs925835215 794 dbSNP
rs1186519991 798 dbSNP
rs570761218 800 dbSNP
rs1307403090 801 dbSNP
rs965937472 810 dbSNP
rs1191101211 817 dbSNP
rs1018816769 824 dbSNP
rs1449255909 826 dbSNP
rs1410298448 839 dbSNP
rs1004710025 840 dbSNP
rs950568690 842 dbSNP
rs1434046996 853 dbSNP
rs1402270481 854 dbSNP
rs1416747249 858 dbSNP
rs1329215034 870 dbSNP
rs1027842592 883 dbSNP
rs1404704621 883 dbSNP
rs1298191231 884 dbSNP
rs677652 891 dbSNP
rs1210824398 892 dbSNP
rs894851676 892 dbSNP
rs968069484 895 dbSNP
rs1029437924 898 dbSNP
rs1486347206 899 dbSNP
rs61506958 900 dbSNP
rs1241139367 902 dbSNP
rs1475542466 921 dbSNP
rs1003206090 922 dbSNP
rs572275536 923 dbSNP
rs1422829742 928 dbSNP
rs1453684998 930 dbSNP
rs996256759 932 dbSNP
rs769367709 938 dbSNP
rs1377254622 940 dbSNP
rs191989311 942 dbSNP
rs1316398607 967 dbSNP
rs1344763967 970 dbSNP
rs12272150 978 dbSNP
rs1005020560 980 dbSNP
rs1431768192 981 dbSNP
rs1290948345 985 dbSNP
rs1369281791 987 dbSNP
rs654000 988 dbSNP
rs945558259 998 dbSNP
rs1350750937 1005 dbSNP
rs915430318 1006 dbSNP
rs1292597471 1007 dbSNP
rs2076884 1008 dbSNP
rs1353142101 1012 dbSNP
rs779834168 1022 dbSNP
rs1217542124 1025 dbSNP
rs1283960639 1040 dbSNP
rs1467852378 1041 dbSNP
rs556230155 1042 dbSNP
rs1242675833 1043 dbSNP
rs1377847317 1045 dbSNP
rs995529105 1046 dbSNP
rs1396810064 1058 dbSNP
rs1279942432 1063 dbSNP
rs653598 1064 dbSNP
rs117232802 1069 dbSNP
rs688911 1070 dbSNP
rs534146828 1076 dbSNP
rs911840383 1077 dbSNP
rs571870500 1080 dbSNP
rs551793501 1081 dbSNP
rs1421152664 1084 dbSNP
rs1225020363 1087 dbSNP
rs59513875 1101 dbSNP
rs1214018236 1113 dbSNP
rs1254670921 1115 dbSNP
rs959189573 1122 dbSNP
rs934494213 1131 dbSNP
rs925825365 1133 dbSNP
rs978689283 1134 dbSNP
rs756914782 1138 dbSNP
rs563310976 1140 dbSNP
rs921209333 1144 dbSNP
rs1461120682 1145 dbSNP
rs1283986388 1155 dbSNP
rs975120869 1158 dbSNP
rs760930867 1171 dbSNP
rs1397187894 1174 dbSNP
rs376756277 1177 dbSNP
rs906178872 1177 dbSNP
rs1354725063 1178 dbSNP
rs1018999107 1179 dbSNP
rs983573736 1185 dbSNP
rs1354368933 1189 dbSNP
rs1342679673 1194 dbSNP
rs1274770421 1195 dbSNP
rs950852258 1196 dbSNP
rs1195057651 1200 dbSNP
rs1273611772 1201 dbSNP
rs187234578 1207 dbSNP
rs181799150 1210 dbSNP
rs906083156 1213 dbSNP
rs932810133 1225 dbSNP
rs148757278 1226 dbSNP
rs1474982678 1228 dbSNP
rs1188888024 1230 dbSNP
rs1295836354 1231 dbSNP
rs899963941 1252 dbSNP
rs541184762 1253 dbSNP
rs1345238788 1254 dbSNP
rs1041098796 1257 dbSNP
rs1014300794 1261 dbSNP
rs895527101 1262 dbSNP
rs1412390646 1264 dbSNP
rs529831484 1265 dbSNP
rs1324380599 1270 dbSNP
rs1226411092 1276 dbSNP
rs572154527 1277 dbSNP
rs934440419 1283 dbSNP
rs904348176 1284 dbSNP
rs1043259085 1289 dbSNP
rs774216126 1290 dbSNP
rs1208681927 1291 dbSNP
rs565139945 1297 dbSNP
rs770847118 1304 dbSNP
rs921145077 1308 dbSNP
rs929241325 1309 dbSNP
rs2368227 1317 dbSNP
rs1486261859 1318 dbSNP
rs973292852 1322 dbSNP
rs959178866 1324 dbSNP
rs1395062732 1329 dbSNP
rs878934805 1335 dbSNP
rs1208363890 1342 dbSNP
rs1314242939 1347 dbSNP
rs1382233298 1356 dbSNP
rs1381310787 1364 dbSNP
rs944687195 1378 dbSNP
rs151200755 1382 dbSNP
rs983519932 1384 dbSNP
rs1231875573 1386 dbSNP
rs950799452 1390 dbSNP
rs1027755469 1394 dbSNP
rs1302573322 1396 dbSNP
rs1223846007 1397 dbSNP
rs1317253716 1398 dbSNP
rs1257846971 1399 dbSNP
rs1204806641 1400 dbSNP
rs1484988555 1400 dbSNP
rs1276274169 1401 dbSNP
rs1466511728 1402 dbSNP
rs1192214784 1403 dbSNP
rs1220368943 1420 dbSNP
rs1455087159 1423 dbSNP
rs1158769560 1424 dbSNP
rs1174907045 1424 dbSNP
rs1238483771 1424 dbSNP
rs1303449355 1424 dbSNP
rs1361580019 1424 dbSNP
rs1371570094 1424 dbSNP
rs137901699 1424 dbSNP
rs1386762991 1424 dbSNP
rs1394727933 1424 dbSNP
rs1435500894 1424 dbSNP
rs1438440709 1424 dbSNP
rs1452483968 1424 dbSNP
rs973949667 1425 dbSNP
rs1331574874 1426 dbSNP
rs1362116666 1427 dbSNP
rs970256285 1428 dbSNP
rs1469262521 1431 dbSNP
rs752152935 1432 dbSNP
rs970436636 1434 dbSNP
rs1023637797 1435 dbSNP
rs375816038 1438 dbSNP
rs1014544563 1440 dbSNP
rs895474965 1443 dbSNP
rs1181993430 1445 dbSNP
rs1031323258 1448 dbSNP
rs1459560619 1454 dbSNP
rs1020627867 1456 dbSNP
rs1394986069 1457 dbSNP
rs190385057 1462 dbSNP
rs1296357354 1470 dbSNP
rs1445367786 1475 dbSNP
rs1360481370 1489 dbSNP
rs894096734 1495 dbSNP
rs1337834461 1503 dbSNP
rs540952582 1505 dbSNP
rs1390887622 1513 dbSNP
rs1465467293 1514 dbSNP
rs1352492252 1519 dbSNP
rs142147153 1527 dbSNP
rs1042821472 1529 dbSNP
rs573763706 1533 dbSNP
rs1250128818 1535 dbSNP
rs1480596850 1537 dbSNP
rs1195811785 1545 dbSNP
rs186069427 1546 dbSNP
rs1473999454 1551 dbSNP
rs1429623464 1554 dbSNP
rs899995187 1555 dbSNP
rs899704264 1571 dbSNP
rs1041352287 1583 dbSNP
rs943962707 1584 dbSNP
rs1353787291 1588 dbSNP
rs181431959 1593 dbSNP
rs148639401 1596 dbSNP
rs583581 1599 dbSNP
rs1372518995 1601 dbSNP
rs931296403 1609 dbSNP
rs1180131575 1612 dbSNP
rs929303906 1615 dbSNP
rs920549780 1622 dbSNP
rs1038002916 1627 dbSNP
rs1243934837 1634 dbSNP
rs920638632 1635 dbSNP
rs937887108 1636 dbSNP
rs1457194022 1639 dbSNP
rs926455551 1640 dbSNP
rs1484391066 1649 dbSNP
rs973553087 1650 dbSNP
rs970625463 1655 dbSNP
rs538186940 1657 dbSNP
rs916112523 1683 dbSNP
rs913640088 1687 dbSNP
rs569646329 1689 dbSNP
rs993022923 1690 dbSNP
rs960257904 1698 dbSNP
rs1031899130 1701 dbSNP
rs1311411817 1710 dbSNP
rs114843934 1715 dbSNP
rs529728305 1716 dbSNP
rs1032620089 1717 dbSNP
rs1315363247 1719 dbSNP
rs1445561383 1724 dbSNP
rs1398640872 1728 dbSNP
rs1333705925 1731 dbSNP
rs997076157 1732 dbSNP
rs1021788969 1738 dbSNP
rs1349760779 1741 dbSNP
rs996643062 1743 dbSNP
rs1287446419 1744 dbSNP
rs899651062 1747 dbSNP
rs1040905717 1749 dbSNP
rs71469161 1751 dbSNP
rs1346422906 1757 dbSNP
rs1232838649 1759 dbSNP
rs1008079650 1762 dbSNP
rs138950204 1774 dbSNP
rs796134524 1780 dbSNP
rs188500918 1805 dbSNP
rs1241197311 1807 dbSNP
rs547178411 1812 dbSNP
rs567684893 1815 dbSNP
rs1480934145 1819 dbSNP
rs1047019546 1821 dbSNP
rs637523 1825 dbSNP
rs1250993448 1832 dbSNP
rs564968158 1836 dbSNP
rs920641477 1840 dbSNP
rs1219252002 1843 dbSNP
rs1416283111 1852 dbSNP
rs1361044015 1858 dbSNP
rs1157166595 1859 dbSNP
rs1344887752 1863 dbSNP
rs1291862828 1870 dbSNP
rs995543345 1872 dbSNP
rs1038181456 1879 dbSNP
rs780791564 1882 dbSNP
rs1369350964 1887 dbSNP
rs568725662 1897 dbSNP
rs1274877577 1900 dbSNP
rs74858720 1903 dbSNP
rs1221622752 1906 dbSNP
rs1283118718 1909 dbSNP
rs562460023 1911 dbSNP
rs1210303704 1914 dbSNP
rs937918196 1922 dbSNP
rs1467946437 1930 dbSNP
rs924827343 1936 dbSNP
rs926487685 1942 dbSNP
rs977682869 1944 dbSNP
rs1479041890 1946 dbSNP
rs1175621470 1947 dbSNP
rs867630582 1948 dbSNP
rs1459888059 1950 dbSNP
rs1021318648 1952 dbSNP
rs949192674 1957 dbSNP
rs542575493 1958 dbSNP
rs75006513 1960 dbSNP
rs554239687 1963 dbSNP
rs1418117773 1964 dbSNP
rs1382356879 1965 dbSNP
rs1019386040 1970 dbSNP
rs866877041 1972 dbSNP
rs1278462736 1976 dbSNP
rs1008028754 1977 dbSNP
rs1229886749 1981 dbSNP
rs1291100162 1983 dbSNP
rs143951336 1989 dbSNP
rs924957112 1996 dbSNP
rs1419501816 2014 dbSNP
rs1291929549 2018 dbSNP
rs1436011113 2020 dbSNP
rs1202454854 2022 dbSNP
rs1232396176 2025 dbSNP
rs757744881 2027 dbSNP
rs995454141 2036 dbSNP
rs578110322 2046 dbSNP
rs1416018757 2047 dbSNP
rs1019813838 2050 dbSNP
rs754178824 2055 dbSNP
rs1393444018 2073 dbSNP
rs951611229 2079 dbSNP
rs183832096 2080 dbSNP
rs996007973 2081 dbSNP
rs1351094122 2083 dbSNP
rs1310686115 2086 dbSNP
rs595855 2091 dbSNP
rs1001533757 2093 dbSNP
rs1239288285 2095 dbSNP
rs1312039361 2101 dbSNP
rs1299642717 2104 dbSNP
rs905145990 2108 dbSNP
rs569536310 2109 dbSNP
rs1255593047 2123 dbSNP
rs1346635340 2126 dbSNP
rs1297687708 2139 dbSNP
rs1398188162 2143 dbSNP
rs1188625900 2145 dbSNP
rs542712131 2149 dbSNP
rs892313796 2152 dbSNP
rs1159420486 2153 dbSNP
rs1057148532 2154 dbSNP
rs938849297 2155 dbSNP
rs1376858665 2156 dbSNP
rs1173621995 2159 dbSNP
rs536205724 2163 dbSNP
rs982436435 2172 dbSNP
rs1310543896 2176 dbSNP
rs1374408813 2190 dbSNP
rs936428075 2192 dbSNP
rs1429861305 2196 dbSNP
rs1324432969 2197 dbSNP
rs1192815556 2198 dbSNP
rs1429824767 2201 dbSNP
rs1298223039 2202 dbSNP
rs1487050929 2214 dbSNP
rs924815523 2216 dbSNP
rs925051852 2217 dbSNP
rs977630522 2218 dbSNP
rs55897744 2224 dbSNP
rs1278317085 2226 dbSNP
rs942355060 2230 dbSNP
rs547458957 2244 dbSNP
rs914825345 2259 dbSNP
rs1258592485 2261 dbSNP
rs975075323 2266 dbSNP
rs964056301 2275 dbSNP
rs987030419 2277 dbSNP
rs1019333568 2283 dbSNP
rs527424361 2285 dbSNP
rs986584415 2294 dbSNP
rs1451892615 2295 dbSNP
rs1254683155 2296 dbSNP
rs951182026 2299 dbSNP
rs1225708062 2301 dbSNP
rs571341047 2305 dbSNP
rs974228714 2316 dbSNP
rs192596041 2317 dbSNP
rs1399888706 2318 dbSNP
rs1320981575 2321 dbSNP
rs963160168 2322 dbSNP
rs1034426554 2325 dbSNP
rs1278150217 2337 dbSNP
rs995767757 2338 dbSNP
rs1217280363 2340 dbSNP
rs907184650 2342 dbSNP
rs866201774 2345 dbSNP
rs767843033 2352 dbSNP
rs115244110 2356 dbSNP
rs368679525 2359 dbSNP
rs1348818519 2361 dbSNP
rs1023981564 2366 dbSNP
rs1328283548 2376 dbSNP
rs562398794 2391 dbSNP
rs894521356 2392 dbSNP
rs1400309117 2413 dbSNP
rs1361636332 2426 dbSNP
rs936507533 2429 dbSNP
rs1390530739 2433 dbSNP
rs1300906698 2435 dbSNP
rs1459727272 2440 dbSNP
rs376304229 2444 dbSNP
rs938796156 2460 dbSNP
rs1039408304 2461 dbSNP
rs1387360523 2463 dbSNP
rs903343143 2464 dbSNP
rs117329021 2466 dbSNP
rs986395420 2476 dbSNP
rs1374361285 2477 dbSNP
rs529243969 2478 dbSNP
rs1422926788 2489 dbSNP
rs766255882 2493 dbSNP
rs1265363747 2499 dbSNP
rs976071137 2502 dbSNP
rs942374263 2503 dbSNP
rs560317407 2505 dbSNP
rs564451988 2507 dbSNP
rs1472002158 2510 dbSNP
rs624328 2515 dbSNP
rs3802868 2516 dbSNP
rs386757933 2517 dbSNP
rs879463975 2517 dbSNP
rs761591832 2519 dbSNP
rs1474103029 2528 dbSNP
rs962898437 2533 dbSNP
rs1368927567 2534 dbSNP
rs1244118589 2535 dbSNP
rs1338736438 2537 dbSNP
rs1394381439 2541 dbSNP
rs598131 2545 dbSNP
rs544774654 2549 dbSNP
rs1406546799 2550 dbSNP
rs1231770803 2552 dbSNP
rs1312475029 2558 dbSNP
rs980202509 2563 dbSNP
rs1247587901 2567 dbSNP
rs768238886 2568 dbSNP
rs746533707 2571 dbSNP
rs1205339893 2573 dbSNP
rs1408193024 2574 dbSNP
rs1012610799 2575 dbSNP
rs575911632 2576 dbSNP
rs775018017 2581 dbSNP
rs1181021841 2584 dbSNP
rs1168029315 2588 dbSNP
rs1456992968 2589 dbSNP
rs560769084 2591 dbSNP
rs1168200781 2603 dbSNP
rs1035676792 2604 dbSNP
rs1429182709 2607 dbSNP
rs749842448 2616 dbSNP
rs541922010 2619 dbSNP
rs1042199621 2621 dbSNP
rs1030902868 2622 dbSNP
rs1001128989 2625 dbSNP
rs1302531049 2626 dbSNP
rs775565965 2633 dbSNP
rs1398217961 2635 dbSNP
rs1039482589 2638 dbSNP
rs1342085102 2641 dbSNP
rs142836019 2643 dbSNP
rs1276186736 2650 dbSNP
rs748468009 2653 dbSNP
rs1440097220 2656 dbSNP
rs143463066 2659 dbSNP
rs567231647 2662 dbSNP
rs771893282 2673 dbSNP
rs918863200 2683 dbSNP
rs556548934 2685 dbSNP
rs1189241047 2688 dbSNP
rs941585244 2694 dbSNP
rs1293958000 2701 dbSNP
rs1247075554 2710 dbSNP
rs139441684 2712 dbSNP
rs929636480 2724 dbSNP
rs533800262 2725 dbSNP
rs3802869 2732 dbSNP
rs1318982043 2738 dbSNP
rs1365044883 2741 dbSNP
rs1436507712 2743 dbSNP
rs1300496998 2751 dbSNP
rs974269909 2760 dbSNP
rs1218187672 2764 dbSNP
rs956045360 2776 dbSNP
rs79558471 2789 dbSNP
rs1000801387 2796 dbSNP
rs1018064934 2797 dbSNP
rs967904136 2797 dbSNP
rs1363248929 2799 dbSNP
rs1164924653 2800 dbSNP
rs1424956000 2806 dbSNP
rs1477079828 2817 dbSNP
rs1006675119 2827 dbSNP
rs1426068478 2830 dbSNP
rs890909278 2832 dbSNP
rs916427579 2843 dbSNP
rs990733676 2844 dbSNP
rs1235824707 2845 dbSNP
rs1471374298 2846 dbSNP
rs549685896 2852 dbSNP
rs1323118330 2853 dbSNP
rs1348709810 2854 dbSNP
rs190473473 2856 dbSNP
rs1274940933 2859 dbSNP
rs1369222753 2863 dbSNP
rs994263151 2874 dbSNP
rs577349866 2884 dbSNP
rs1038417409 2890 dbSNP
rs758376000 2891 dbSNP
rs1210431451 2905 dbSNP
rs1271123114 2920 dbSNP
rs548852000 2923 dbSNP
rs185800745 2924 dbSNP
rs927492305 2925 dbSNP
rs1489530719 2933 dbSNP
rs1450389367 2943 dbSNP
rs375612171 2951 dbSNP
rs1002793175 2955 dbSNP
rs950182534 2958 dbSNP
rs1161825907 2959 dbSNP
rs1353305743 2960 dbSNP
rs967352576 2961 dbSNP
rs1405313570 2963 dbSNP
rs917342580 2968 dbSNP
rs1225628229 2969 dbSNP
rs1352582228 2971 dbSNP
rs988928342 2973 dbSNP
rs956288425 2974 dbSNP
rs1020364492 2975 dbSNP
rs1012105059 2978 dbSNP
rs1304476156 2980 dbSNP
rs893288336 2989 dbSNP
rs1355507051 3000 dbSNP
rs967977404 3008 dbSNP
rs1018139659 3015 dbSNP
rs1323566921 3018 dbSNP
rs1315802550 3031 dbSNP
rs1402015109 3037 dbSNP
rs1409260366 3043 dbSNP
rs1172345101 3052 dbSNP
rs879355788 3061 dbSNP
rs1236116400 3069 dbSNP
rs1006707771 3074 dbSNP
rs193069758 3077 dbSNP
rs1416676218 3078 dbSNP
rs78276561 3083 dbSNP
rs1261043500 3090 dbSNP
rs1370741034 3095 dbSNP
rs891350074 3100 dbSNP
rs1447788072 3102 dbSNP
rs147543610 3103 dbSNP
rs1285875170 3104 dbSNP
rs1339974969 3106 dbSNP
rs371820992 3109 dbSNP
rs564376955 3112 dbSNP
rs929626800 3113 dbSNP
rs765145949 3124 dbSNP
rs1343089844 3125 dbSNP
rs367618369 3126 dbSNP
rs187511616 3127 dbSNP
rs1442205686 3130 dbSNP
rs776339547 3133 dbSNP
rs558885979 3134 dbSNP
rs760427229 3144 dbSNP
rs1432529704 3147 dbSNP
rs906150905 3148 dbSNP
rs534122596 3156 dbSNP
rs1170429111 3165 dbSNP
rs991032311 3166 dbSNP
rs575899129 3167 dbSNP
rs895997161 3172 dbSNP
rs66601680 3174 dbSNP
rs66917625 3174 dbSNP
rs760606126 3174 dbSNP
rs611063 3184 dbSNP
rs610796 3198 dbSNP
rs1273234212 3210 dbSNP
rs1344596457 3215 dbSNP
rs978765344 3222 dbSNP
rs967342526 3224 dbSNP
rs771680957 3226 dbSNP
rs1475889540 3227 dbSNP
rs143338408 3229 dbSNP
rs957658201 3230 dbSNP
rs1376655666 3231 dbSNP
rs985363550 3231 dbSNP
rs1018370023 3232 dbSNP
rs1007024558 3234 dbSNP
rs553639529 3236 dbSNP
rs1390755111 3242 dbSNP
rs74218627 3245 dbSNP
rs972940432 3246 dbSNP
rs75943170 3247 dbSNP
rs1017090077 3254 dbSNP
rs1285489437 3256 dbSNP
rs896799562 3257 dbSNP
rs1038420591 3258 dbSNP
rs1005243134 3269 dbSNP
rs557424609 3274 dbSNP
rs905543931 3274 dbSNP
rs1022606822 3278 dbSNP
rs1014520867 3288 dbSNP
rs894853207 3293 dbSNP
rs1266089619 3304 dbSNP
rs1451715451 3310 dbSNP
rs1361985041 3317 dbSNP
rs1201104587 3319 dbSNP
rs1409381768 3319 dbSNP
rs773872053 3322 dbSNP
rs1449935492 3327 dbSNP
rs1414031803 3329 dbSNP
rs1456360760 3331 dbSNP
rs1385435532 3360 dbSNP
rs1390084700 3372 dbSNP
rs611960 3374 dbSNP
rs927834037 3375 dbSNP
rs611979 3379 dbSNP
rs1353240024 3380 dbSNP
rs1409532705 3389 dbSNP
rs1043103595 3391 dbSNP
rs532168547 3392 dbSNP
rs915176954 3399 dbSNP
rs11216788 3401 dbSNP
rs1181985261 3415 dbSNP
rs535652256 3419 dbSNP
rs1244806832 3421 dbSNP
rs987400101 3424 dbSNP
rs566606706 3428 dbSNP
rs933927783 3432 dbSNP
rs922510882 3433 dbSNP
rs1480290604 3436 dbSNP
rs1018772866 3437 dbSNP
rs1421890742 3451 dbSNP
rs1163976691 3455 dbSNP
rs1369059110 3456 dbSNP
rs1425301759 3465 dbSNP
rs755273421 3468 dbSNP
rs1206476130 3470 dbSNP
rs1307578732 3474 dbSNP
rs543264926 3476 dbSNP
rs1308906949 3478 dbSNP
rs955513435 3479 dbSNP
rs1375951686 3481 dbSNP
rs1394713035 3489 dbSNP
rs1243396720 3493 dbSNP
rs1029859135 3494 dbSNP
rs1341607109 3496 dbSNP
rs994354875 3513 dbSNP
rs138926780 3515 dbSNP
rs1271903059 3518 dbSNP
rs1017194745 3519 dbSNP
rs1005588666 3526 dbSNP
rs1371570382 3533 dbSNP
rs894847619 3535 dbSNP
rs1300435700 3539 dbSNP
rs1252764560 3544 dbSNP
rs1443478452 3559 dbSNP
rs1054792369 3560 dbSNP
rs1181077724 3567 dbSNP
rs564544306 3583 dbSNP
rs1446389729 3592 dbSNP
rs752140026 3594 dbSNP
rs1185448400 3596 dbSNP
rs780133620 3600 dbSNP
rs758561270 3604 dbSNP
rs1429244220 3617 dbSNP
rs1171378611 3624 dbSNP
rs1356563331 3627 dbSNP
rs1464798187 3630 dbSNP
rs1022639369 3632 dbSNP
rs1013924277 3635 dbSNP
rs1426844800 3637 dbSNP
rs1403486657 3639 dbSNP
rs960352472 3661 dbSNP
rs1386057702 3663 dbSNP
rs1032327299 3665 dbSNP
rs906312126 3666 dbSNP
rs1297199639 3686 dbSNP
rs551078829 3691 dbSNP
rs945239224 3696 dbSNP
rs915106775 3701 dbSNP
rs1256398193 3702 dbSNP
rs1462516420 3703 dbSNP
rs1206717180 3704 dbSNP
rs989451772 3708 dbSNP
rs1007607903 3716 dbSNP
rs1448934446 3716 dbSNP
rs150248095 3718 dbSNP
rs889161484 3724 dbSNP
rs1480913895 3729 dbSNP
rs1407272458 3745 dbSNP
rs1267620311 3765 dbSNP
rs562179349 3768 dbSNP
rs935993176 3777 dbSNP
rs1219588638 3781 dbSNP
rs1051755357 3786 dbSNP
rs933311805 3788 dbSNP
rs79825510 3790 dbSNP
rs542204653 3792 dbSNP
rs1325402616 3796 dbSNP
rs1292085535 3797 dbSNP
rs1037371741 3798 dbSNP
rs1237810897 3799 dbSNP
rs1315512709 3809 dbSNP
rs608176 3813 dbSNP
rs1243888372 3814 dbSNP
rs559793938 3815 dbSNP
rs766966254 3820 dbSNP
rs1487575666 3821 dbSNP
rs1367489666 3834 dbSNP
rs1190818067 3847 dbSNP
rs1301415690 3851 dbSNP
rs1406877496 3852 dbSNP
rs955417262 3858 dbSNP
rs191690025 3859 dbSNP
rs972862403 3860 dbSNP
rs969832844 3869 dbSNP
rs758772885 3876 dbSNP
rs915655287 3883 dbSNP
rs961570727 3884 dbSNP
rs116573405 3892 dbSNP
rs1347584702 3895 dbSNP
rs1419645452 3907 dbSNP
rs1435200175 3913 dbSNP
rs141919315 3916 dbSNP
rs537466784 3919 dbSNP
rs1347011521 3930 dbSNP
rs570959443 3934 dbSNP
rs1005833584 3935 dbSNP
rs1287524282 3938 dbSNP
rs148125741 3939 dbSNP
rs1031311694 3940 dbSNP
rs1197133147 3941 dbSNP
rs999526868 3945 dbSNP
rs1319998053 3956 dbSNP
rs778826251 3958 dbSNP
rs1220936228 3962 dbSNP
rs1490701491 3968 dbSNP
rs1269803861 3969 dbSNP
rs1268899099 3978 dbSNP
rs968909122 3979 dbSNP
rs186849266 3980 dbSNP
rs76607319 3984 dbSNP
rs1042125439 3996 dbSNP
rs1470743962 3999 dbSNP
rs757138525 4003 dbSNP
rs1264207805 4009 dbSNP
rs1412348277 4013 dbSNP
rs1404172585 4019 dbSNP
rs1163680508 4021 dbSNP
rs566704524 4029 dbSNP
rs115357119 4042 dbSNP
rs539755265 4056 dbSNP
rs625464 4057 dbSNP
rs943325441 4068 dbSNP
rs910488809 4074 dbSNP
rs1378371400 4076 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_004588 | 3UTR | AAAAAAAAAAAAAAAAAAAAAAAAAGGCAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000278947.5 | 3UTR | UAGAGAGACUCCAUCUCAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000278947.5 | 3UTR | UAGAGAGACUCCAUCUCAAAAAAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000278947.5 | 3UTR | UAGAGAGACUCCAUCUCAAAAAAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4708-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT095681 RBM27 RNA binding motif protein 27 2 4
MIRT104033 USP42 ubiquitin specific peptidase 42 2 6
MIRT114773 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT246923 CCND1 cyclin D1 2 2
MIRT392569 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT443949 LRIT3 leucine rich repeat, Ig-like and transmembrane domains 3 2 2
MIRT446695 PAPPA pappalysin 1 2 2
MIRT447383 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 2 2
MIRT449321 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT449717 C1orf61 chromosome 1 open reading frame 61 2 2
MIRT449738 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT450531 PGLS 6-phosphogluconolactonase 2 2
MIRT455650 YARS tyrosyl-tRNA synthetase 2 2
MIRT458036 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463468 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT466677 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 4
MIRT467789 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468167 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT468652 SECISBP2L SECIS binding protein 2 like 2 6
MIRT469380 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT470346 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT472418 NCKAP1 NCK associated protein 1 2 2
MIRT474612 KLF3 Kruppel like factor 3 2 2
MIRT478703 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT481008 BBC3 BCL2 binding component 3 2 4
MIRT483098 TFPI tissue factor pathway inhibitor 2 2
MIRT485113 SHISA6 shisa family member 6 2 2
MIRT497533 ZNF607 zinc finger protein 607 2 2
MIRT500644 TUBB2A tubulin beta 2A class IIa 2 6
MIRT500890 STRN striatin 2 4
MIRT501900 MED13 mediator complex subunit 13 2 2
MIRT506646 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT512675 ENO4 enolase family member 4 2 2
MIRT516977 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT528754 RPS27 ribosomal protein S27 2 6
MIRT539670 ZBTB44 zinc finger and BTB domain containing 44 2 2
MIRT544129 PPIL1 peptidylprolyl isomerase like 1 2 2
MIRT546382 STOX2 storkhead box 2 2 4
MIRT562143 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT568713 TMEM30B transmembrane protein 30B 2 2
MIRT571029 CENPP centromere protein P 2 2
MIRT572781 ZNF277 zinc finger protein 277 2 2
MIRT573162 SLC30A9 solute carrier family 30 member 9 2 2
MIRT609126 NUDT3 nudix hydrolase 3 2 2
MIRT609284 OAS3 2'-5'-oligoadenylate synthetase 3 2 2
MIRT613430 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 2 2
MIRT613770 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT616645 LRAT lecithin retinol acyltransferase 2 4
MIRT630892 SLC25A33 solute carrier family 25 member 33 2 2
MIRT636526 FAXC failed axon connections homolog 2 4
MIRT641394 NUBPL nucleotide binding protein like 2 2
MIRT641412 SCN2B sodium voltage-gated channel beta subunit 2 2 2
MIRT642528 CERS4 ceramide synthase 4 2 2
MIRT643186 HYPK huntingtin interacting protein K 2 2
MIRT647800 FRMD8 FERM domain containing 8 2 2
MIRT652150 TRIM71 tripartite motif containing 71 2 2
MIRT652602 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT661606 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT666339 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT670414 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671122 ZNF573 zinc finger protein 573 2 2
MIRT671155 ANKRD9 ankyrin repeat domain 9 2 2
MIRT671338 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT671869 ZNF429 zinc finger protein 429 2 2
MIRT671974 IKZF3 IKAROS family zinc finger 3 2 2
MIRT672064 KIAA0930 KIAA0930 2 2
MIRT672654 SLC25A16 solute carrier family 25 member 16 2 4
MIRT672673 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT672771 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672929 LRRC2 leucine rich repeat containing 2 2 2
MIRT673159 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673272 RUNDC1 RUN domain containing 1 2 2
MIRT673332 THAP1 THAP domain containing 1 2 2
MIRT673351 SLC35F6 solute carrier family 35 member F6 2 2
MIRT673667 ZNF440 zinc finger protein 440 2 2
MIRT673904 DCTN6 dynactin subunit 6 2 2
MIRT674096 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT674401 MYCBP MYC binding protein 2 2
MIRT674525 PRR23A proline rich 23A 2 2
MIRT674793 NPR1 natriuretic peptide receptor 1 2 2
MIRT674833 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 2
MIRT675066 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT675080 CCR6 C-C motif chemokine receptor 6 2 2
MIRT675126 FSD2 fibronectin type III and SPRY domain containing 2 2 2
MIRT679401 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT689229 RPS19 ribosomal protein S19 2 2
MIRT694008 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT699671 SFT2D2 SFT2 domain containing 2 2 2
MIRT706213 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706548 GJD2 gap junction protein delta 2 2 2
MIRT707418 RRP7A ribosomal RNA processing 7 homolog A 2 2
MIRT710648 GLUL glutamate-ammonia ligase 2 2
MIRT719393 NPCA1 Nasopharyngeal carcinoma 1 2 2
MIRT720166 PNPO pyridoxamine 5'-phosphate oxidase 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4708-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4708-5p Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-4708-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4708-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)

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