pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DEFB118   
Synonyms C20orf63, DEFB-18, ESC42, ESP13.6
Description defensin beta 118
Transcript NM_054112   
Expression
Putative miRNA Targets on DEFB118
3'UTR of DEFB118
(miRNA target sites are highlighted)
>DEFB118|NM_054112|3'UTR
   1 CTTCCTCTCGGCTATCACTCACCCCTGTCCTCAGAGTGATAAACTAAGTCACATACAGATAAAGCACTGAAAACACCACA
  81 GTGACCCTCCCACCCCCCACCAATATGTAATTCTATTAATAGAAACAGCTGTGTAAAGAAGTCTAAAATTTTCACTATTT
 161 CCAATGATAAACTCTTCAGTGCTCTTCTTGAAATGTCACATTATTTCCACAACAAGTTATAACCTATTTTTAGTATTTCT
 241 TGTTTGCTAGTGACCTATGCACAACTTCAATAGCTTAGTTAGCTATTCCAACAACAATTTCTTCATGTATCGTTCTGTCT
 321 TCTCAACAGCTGTCTTCATGGCAGCATAAGTGGTCATGATCAAAATTCTAAATCTTTGCATCTGTGAGAGTAGCTACTAT
 401 GACACTAAAAGCTTTTTTTCTAGAACAGGAGACACTTCAGGTGAAAGCATTCATTCTCCTACTAACTATGGCCTTGGAGC
 481 CAGGTTTTATCTCTCACTGTAGGAAATTGGCCGCCCCAGGTGTGAGCTATGAAGACTCCTTTTTGCCCCAGTGGCTTTGG
 561 GGTTGAAATGCTGTCGAAAAGCTTTTATGGCTCTGTAGACCCATCTTTTTGACCAAGCCTTGATCACACATGGACATCCA
 641 AGGGTAATCATGGACCCCCAATTGTGGGTGAAAGGATGGATCATTTATCTACCTGATTACTGAGAGCTTTATTTGTCTCC
 721 CTCTGATAGCAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaucGGAGGUACUU---AAGACuac 5'
              :||:|||| |   |||||   
Target 5' aattTCTTCATGTATCGTTCTGtct 3'
296 - 320 122.00 -13.32
2
miRNA  3' gauCGGAGGUACUUAAGACUAc 5'
             |:||||      |||||| 
Target 5' tttGTCTCCC-----TCTGATa 3'
712 - 728 121.00 -10.40
3
miRNA  3' gaUCGGAGGUACUUAAGACUac 5'
            || | ||||   ||:|||  
Target 5' gtAGAC-CCAT-CTTTTTGAcc 3'
595 - 614 114.00 -7.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30125501 10 COSMIC
COSN30107497 12 COSMIC
COSN30185053 31 COSMIC
COSN30456445 39 COSMIC
COSN30137588 51 COSMIC
COSN17378273 58 COSMIC
COSN30477829 59 COSMIC
COSN30478039 87 COSMIC
COSN26487563 91 COSMIC
COSN26154459 97 COSMIC
COSN30468505 98 COSMIC
COSN30648194 99 COSMIC
COSN31606421 114 COSMIC
COSN30164200 121 COSMIC
COSN30127379 144 COSMIC
COSN1247404 331 COSMIC
COSN27249510 514 COSMIC
COSN26852536 623 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1195951106 6 dbSNP
rs117277015 7 dbSNP
rs765218036 10 dbSNP
rs775702515 11 dbSNP
rs1237586846 14 dbSNP
rs763094787 16 dbSNP
rs1406354131 17 dbSNP
rs763909757 23 dbSNP
rs751307943 24 dbSNP
rs756982789 25 dbSNP
rs748532018 26 dbSNP
rs1478025027 35 dbSNP
rs767532457 36 dbSNP
rs1423302163 41 dbSNP
rs540058957 45 dbSNP
rs755712081 46 dbSNP
rs779636156 48 dbSNP
rs748975030 49 dbSNP
rs182368086 51 dbSNP
rs1405513249 60 dbSNP
rs1264079741 61 dbSNP
rs1218808647 76 dbSNP
rs569243788 78 dbSNP
rs1223022677 80 dbSNP
rs1025890096 85 dbSNP
rs1276358207 86 dbSNP
rs960385925 90 dbSNP
rs992204363 92 dbSNP
rs1401229021 93 dbSNP
rs1023391159 94 dbSNP
rs866104437 99 dbSNP
rs995230027 104 dbSNP
rs1427745280 106 dbSNP
rs1174727207 107 dbSNP
rs866586564 108 dbSNP
rs148251220 115 dbSNP
rs1264086149 118 dbSNP
rs935151017 121 dbSNP
rs1484906091 125 dbSNP
rs1241571647 126 dbSNP
rs187041124 127 dbSNP
rs1280538660 128 dbSNP
rs1005159533 133 dbSNP
rs1015590856 139 dbSNP
rs1322411347 144 dbSNP
rs923165954 146 dbSNP
rs960776067 157 dbSNP
rs1014013369 158 dbSNP
rs1452214557 165 dbSNP
rs1287751709 166 dbSNP
rs1449492333 169 dbSNP
rs574927405 197 dbSNP
rs1312937548 209 dbSNP
rs1023598884 214 dbSNP
rs934008659 217 dbSNP
rs1469573989 218 dbSNP
rs534042336 223 dbSNP
rs969463541 224 dbSNP
rs1229007758 225 dbSNP
rs772221631 227 dbSNP
rs1272163013 230 dbSNP
rs554202953 231 dbSNP
rs1305724871 236 dbSNP
rs1182504726 237 dbSNP
rs1418974544 237 dbSNP
rs1206291423 238 dbSNP
rs1473091468 243 dbSNP
rs1244827515 247 dbSNP
rs1238575730 258 dbSNP
rs1201571236 262 dbSNP
rs1460670815 266 dbSNP
rs979458473 271 dbSNP
rs1460548738 272 dbSNP
rs1206230144 275 dbSNP
rs1181366094 279 dbSNP
rs748677603 287 dbSNP
rs1038446504 300 dbSNP
rs898694293 303 dbSNP
rs758742517 308 dbSNP
rs1025921359 312 dbSNP
rs988052354 313 dbSNP
rs778149663 329 dbSNP
rs745501948 330 dbSNP
rs912477010 335 dbSNP
rs896704456 345 dbSNP
rs1408739519 354 dbSNP
rs943929457 374 dbSNP
rs1039794373 379 dbSNP
rs920909569 381 dbSNP
rs1443897509 383 dbSNP
rs1013254112 385 dbSNP
rs577247336 388 dbSNP
rs1401492580 397 dbSNP
rs1250371925 400 dbSNP
rs1221689319 405 dbSNP
rs1361034190 406 dbSNP
rs1245969890 413 dbSNP
rs969073625 413 dbSNP
rs979617313 413 dbSNP
rs142733756 421 dbSNP
rs931078264 423 dbSNP
rs1048152088 424 dbSNP
rs956555041 441 dbSNP
rs1294292733 451 dbSNP
rs1342525322 461 dbSNP
rs1448795461 466 dbSNP
rs987905023 468 dbSNP
rs1269693695 474 dbSNP
rs1163005137 481 dbSNP
rs1359705832 488 dbSNP
rs887987581 490 dbSNP
rs1258706054 492 dbSNP
rs986065495 500 dbSNP
rs6119976 503 dbSNP
rs1201588789 506 dbSNP
rs911249375 508 dbSNP
rs942704129 513 dbSNP
rs1005048606 514 dbSNP
rs1266216573 518 dbSNP
rs1215491275 520 dbSNP
rs1355052136 527 dbSNP
rs1036500016 531 dbSNP
rs896735138 534 dbSNP
rs1191787182 538 dbSNP
rs1302381520 540 dbSNP
rs1013815182 548 dbSNP
rs1024071040 553 dbSNP
rs930135444 556 dbSNP
rs1302645612 559 dbSNP
rs1474676916 563 dbSNP
rs1361113265 568 dbSNP
rs1160276737 572 dbSNP
rs1451500609 574 dbSNP
rs905189894 576 dbSNP
rs538948407 577 dbSNP
rs1240032763 582 dbSNP
rs1426685649 588 dbSNP
rs1469581154 588 dbSNP
rs1488305225 590 dbSNP
rs1032380353 592 dbSNP
rs1203940343 595 dbSNP
rs1045305517 604 dbSNP
rs956754058 614 dbSNP
rs45452494 615 dbSNP
rs748561694 619 dbSNP
rs1000512055 625 dbSNP
rs1019419720 631 dbSNP
rs965685591 632 dbSNP
rs1328317046 638 dbSNP
rs1316305944 639 dbSNP
rs6119977 643 dbSNP
rs975342572 645 dbSNP
rs1309151965 652 dbSNP
rs1317647205 657 dbSNP
rs192780034 668 dbSNP
rs867919360 671 dbSNP
rs6119978 675 dbSNP
rs1403466831 676 dbSNP
rs920951677 679 dbSNP
rs1175330736 681 dbSNP
rs1477926538 693 dbSNP
rs1374363661 695 dbSNP
rs1190381763 703 dbSNP
rs772538546 704 dbSNP
rs1257400757 708 dbSNP
rs1343504648 708 dbSNP
rs1206006652 712 dbSNP
rs1460297807 728 dbSNP
rs1262874485 730 dbSNP
rs1401988639 730 dbSNP
rs1165658777 731 dbSNP
rs1315584702 731 dbSNP
rs1335837033 731 dbSNP
rs1341713837 731 dbSNP
rs1380359499 731 dbSNP
rs1398119468 731 dbSNP
rs1454492796 731 dbSNP
rs60446679 731 dbSNP
rs80052265 731 dbSNP
rs956423797 731 dbSNP
rs1278740623 732 dbSNP
rs1344851232 734 dbSNP
rs1221424363 736 dbSNP
rs1276422919 748 dbSNP
rs1461011223 753 dbSNP
rs1186006497 754 dbSNP
rs1345219674 754 dbSNP
rs1369575119 754 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Liver Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2550618. RNA binding protein: AGO2. Condition:Patient 1 Tumor 1 ...

- Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al., 2017, Molecular cell.

Article - Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al.
- Molecular cell, 2017
MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. We observed a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to other genic and non-genic sites. Motif analysis of miR-122-dependent binding revealed a G-bulged motif in addition to canonical motifs. A large number of miR-122 targets were found to be species specific. Upregulation of several common mouse and human targets, most notably BCL9, predicted survival in HCC patients. These results broadly define the molecular consequences of miR-122 downregulation in hepatocellular carcinoma.
LinkOut: [PMID: 28735896]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000253381.2 | 3UTR | GAUAGCAAAAAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.331 0.03 0.024 0.45 31 Click to see details
UCEC -0.888 0.15 -0.625 0.29 3 Click to see details
STAD -0.787 0.21 -0.625 0.29 3 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
HNSC 0.131 0.33 0.152 0.3 14 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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