miRTarBase - #MIRT641784


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pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol YWHAB   
Synonyms GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Description tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Transcript NM_003404   
Other Transcripts NM_139323   
Expression
Putative miRNA Targets on YWHAB
3'UTR of YWHAB
(miRNA target sites are highlighted)		 
>YWHAB|NM_003404|3'UTR
   1 TGTTTCTCGTGCTTTGTGATCTGTTCAGTGTCACTCTGTACCCTCAACATATATCCCTTGTGCGATAAAAAAAAAAAAAA
  81 AAAAAAAAAGAGAATCGTACGTCGACTTTCGATTTTTCACAGCCTCAGCCTAGGAAAAATGGTTCATGGGATAAACAGCT
 161 GGTATTTGTATCTAAAACTCAGATTGGTCACATAAATGCCACGGCATTCCGAAGTTTTGATTTTGATTAACATTGACAGG
 241 ATTACTGTGTGTTTAATTTTTTAAAAACTGAACACTGTGATTATGGGGTTTTGTAATTTAGCAGAACTCTTACTGGTAGA
 321 AAAAATAGACCTGAATTATGTGTAACTTTTTGGAAGGTTTAATCTGATATCAAAATAATCATTGAAATACAATTCCATTG
 401 TAAAGTTGTACAGAAAGTTATAGAGATTATATTGTGATGCTGGAACTTGGAGTGAGACACACATCATTTGGCATTTGAGT
 481 TGAATGGTAATTCACAGTAATGCTGCCGTTGTTCGGGACTTAAAGACACTTGACCTGTTTGGGCTGTTGCCACTTAAAAG
 561 TTCATGACCACAAATGTCCACAGTGTCTTCCTCTGAGGAAACTCGAATCCTGAAATGGAAATTCTTTGTGGCAGATAACT
 641 GGCTTATGACACCTTGAAAAGTTCAAGTGCTCATATAACACACCACACTGAACCCCCTTTCCTACAGCAATATGTTCACT
 721 ATGTTACCAATTTGCAACTTGTGCTTCAATAGTGGAATCTACTTTCATTGTTAACACTGAGCTAAAGAAAAAAAGCCGTG
 801 TGTTTTATGAATGACCTTATCTGTTTCCTGGATAATACCTTTAAGAATAATGTCCTGAGTCAGGCGTGGTGGTGCGTGCA
 881 TCTAGTCCCAACTATTTGGGAGGCTGAGGCAGGAGGATCGCTTGAGCCCAGGAGTTTAAAGCTGCAGTGCCCTGTGGTTG
 961 CACCTGTGAATAACTGCACTCCAGCCTGGGCAACATAGCGAGACCTCATCTCCAAAAAAGAAAACAAAAAACAAAAAAAG
1041 GAATGATGTTCTGTAGAGATGGCCTTTCACTTGAGGAGTACTCAGTTTTCAGGTTCTTCCTAGCTCGGGGCTTTTAAATT
1121 TTGAAATCTAAACATTCTTTCCCACCATCCTTTTTGACTGTTGACCTTGGTTTTCTCTTCTAAGTTTCTGTCCCTCTGCT
1201 TCCTTACTTTTTTTCCTTTTTGAATTCTATCTTTATCTGTCTTTTGTTCACTTTTTAATGCTATATATGGGCAGGGGTGA
1281 GAGACATTACTGAGCACCTTGGTGAGCAAGCCTGGCTTTAAAGATTGGAGAAGAGCTTCTGGCACCAGAACCCTGTCTTC
1361 CTCCAGTTCTCAACACGGTGTTGCTCTTCAGTCATACCGGAATCTGAATCAAAAAAGTATTTTTAAATATCCATGATTTC
1441 TCCCTGTATTGAGGCTAGCCCTGATCATGCTTTTTGTGCCTGTCACCAGGTCTCCCAAGTGCACTCATCCAGGTCAGTGC
1521 TCAGATGTGTTTAAGGAGACCCTATATTCAGGGAAGTTGCGTGAACACTGCAGTGGGGAGAATTGAGAATAGTCAGGCCT
1601 ATCAGTCTCACAGAATCACCCCTCTACCTTTGATATTCCACTTAGCTGTAGAGTCCATCTGTTTGTCCATCTGCTGAAAT
1681 GAGAAAAGAAAAATTTATGCACTGATTTAAAACAAACCAAAAAAAAAGAAAAAAACAAAAAAAAAAATCCCTCCTTTCTA
1761 GCTGAACAAAAATGTGCAGTTAATACTTGGCGCTTGAAAATGCAGTAGTGAATGTGGAACCAAGCCTGTCTGTATATCTG
1841 GTAGCTCTTTTCTTGCTTTGTTTTTTCTTACCAGTATTCTGCCTAACGTTTGCTTCTGTGATGGTTATATTGCCTAGCAA
1921 GCACACCCGTGGTTGTGAAAATAGTATAGCAAAAAAGAAAAATCCCCGGTTATTGATGTACTAGATTTGTGTATGTCTTT
2001 TAAACAGTTCTAGTTTCACCTTACACAGAATAATCAGGAAAAGTGTAAAAATTCAAAAGTGAAATAAAAATTTTATCAGT
2081 TAGTTGCCTGTGAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auGCGGUCAGU-UAU--GGAACACu 5'
            | :||  || |||  ||||||| 
Target 5' acCCTCA-ACATATATCCCTTGTGc 3'
 40 - 63 149.00 -9.80
2 
miRNA  3' augcggucagUUAUGGAACACu 5'
                    ||| |:||||| 
Target 5' ctgaaatggaAATTCTTTGTGg 3'
 610 - 631 136.00 -9.40
3 
miRNA  3' auGCGGUCAGUUAUGGAACACu 5'
            :|::  || :|:|:||||| 
Target 5' --TGTTTCTC-GTGCTTTGTGa 3'
 1 - 19 135.00 -14.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30721241 10 COSMIC
COSN30124059 18 COSMIC
COSN30447767 44 COSMIC
COSN30128504 51 COSMIC
COSN30112576 57 COSMIC
COSN19184540 68 COSMIC
COSN31591192 69 COSMIC
COSN18750188 86 COSMIC
COSN8610994 91 COSMIC
COSN30460587 97 COSMIC
COSN31580556 203 COSMIC
COSN31576208 249 COSMIC
COSN20079808 263 COSMIC
COSN31523432 345 COSMIC
COSN1873483 659 COSMIC
COSN19380372 1044 COSMIC
COSN23758967 1232 COSMIC
COSN7093869 1466 COSMIC
COSN31578850 1605 COSMIC
COSN5971925 1672 COSMIC
COSN26574276 1706 COSMIC
COSN32058169 1727 COSMIC
COSN20116475 1728 COSMIC
COSN7093870 1738 COSMIC
COSN20116477 1740 COSMIC
COSN32062406 1748 COSMIC
COSN31520921 1831 COSMIC
COSN31609408 2072 COSMIC
rs8356 1377 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs771219211 9 dbSNP
rs759679647 10 dbSNP
rs1235142086 14 dbSNP
rs6876 23 dbSNP
rs1187292493 24 dbSNP
rs761211599 26 dbSNP
rs764564466 27 dbSNP
rs754253800 29 dbSNP
rs779759903 32 dbSNP
rs369051047 35 dbSNP
rs1319024239 36 dbSNP
rs754663645 39 dbSNP
rs1269145456 42 dbSNP
rs1478837646 43 dbSNP
rs780912815 48 dbSNP
rs747625868 49 dbSNP
rs1375247020 52 dbSNP
rs375543853 53 dbSNP
rs1451838517 54 dbSNP
rs1311752479 56 dbSNP
rs1352957753 61 dbSNP
rs1383624298 64 dbSNP
rs1491500994 65 dbSNP
rs745674726 65 dbSNP
rs753426740 65 dbSNP
rs1158618301 66 dbSNP
rs1491336736 66 dbSNP
rs1003577121 67 dbSNP
rs1213190681 67 dbSNP
rs1236256545 67 dbSNP
rs1244921042 67 dbSNP
rs1259847857 67 dbSNP
rs1318285393 67 dbSNP
rs1410604112 67 dbSNP
rs1461363404 67 dbSNP
rs1463396358 67 dbSNP
rs775632748 67 dbSNP
rs778717529 67 dbSNP
rs780141521 67 dbSNP
rs879020827 67 dbSNP
rs1325682034 68 dbSNP
rs1288571720 69 dbSNP
rs1224939812 75 dbSNP
rs1282136525 80 dbSNP
rs1348544253 81 dbSNP
rs1209985819 82 dbSNP
rs368162171 83 dbSNP
rs372424925 84 dbSNP
rs768258387 84 dbSNP
rs779890558 84 dbSNP
rs377225648 85 dbSNP
rs1262652505 86 dbSNP
rs1383980556 86 dbSNP
rs3208334 86 dbSNP
rs1166009694 87 dbSNP
rs1428339539 88 dbSNP
rs1035119422 89 dbSNP
rs879169305 89 dbSNP
rs1221520258 90 dbSNP
rs1263407191 90 dbSNP
rs45467003 91 dbSNP
rs1293935300 92 dbSNP
rs1397224788 93 dbSNP
rs959442942 96 dbSNP
rs1294959133 97 dbSNP
rs1012094122 98 dbSNP
rs571580745 101 dbSNP
rs983403898 102 dbSNP
rs1364101694 104 dbSNP
rs1173550718 111 dbSNP
rs907528107 112 dbSNP
rs1454868898 113 dbSNP
rs1372961908 127 dbSNP
rs1167746736 129 dbSNP
rs1289139262 136 dbSNP
rs965708425 137 dbSNP
rs976196688 141 dbSNP
rs1345657033 145 dbSNP
rs533947019 146 dbSNP
rs114425623 147 dbSNP
rs1380132221 157 dbSNP
rs764029229 171 dbSNP
rs753672849 173 dbSNP
rs1225379984 177 dbSNP
rs1049911780 179 dbSNP
rs1233548994 185 dbSNP
rs140521407 186 dbSNP
rs1305366888 188 dbSNP
rs1387669795 193 dbSNP
rs1396464994 203 dbSNP
rs1296935466 204 dbSNP
rs946967970 205 dbSNP
rs1042652767 207 dbSNP
rs542754305 211 dbSNP
rs1241241167 212 dbSNP
rs1199344359 223 dbSNP
rs1261332255 223 dbSNP
rs902490019 229 dbSNP
rs1248390415 233 dbSNP
rs1197467118 246 dbSNP
rs1485681818 249 dbSNP
rs373541930 256 dbSNP
rs1258814815 263 dbSNP
rs575590766 275 dbSNP
rs1056922002 276 dbSNP
rs1203064533 276 dbSNP
rs1255352486 277 dbSNP
rs1276800539 284 dbSNP
rs1234484272 294 dbSNP
rs1335534787 297 dbSNP
rs1305580221 301 dbSNP
rs1469188785 305 dbSNP
rs765432467 308 dbSNP
rs1393651308 313 dbSNP
rs149358399 320 dbSNP
rs564408795 324 dbSNP
rs1467736391 325 dbSNP
rs533471563 331 dbSNP
rs1172774750 334 dbSNP
rs1423657287 347 dbSNP
rs1421348479 349 dbSNP
rs1361841902 353 dbSNP
rs1183652243 357 dbSNP
rs1440266719 364 dbSNP
rs951891541 369 dbSNP
rs1004766963 371 dbSNP
rs1362647769 373 dbSNP
rs1014850290 374 dbSNP
rs1327485932 377 dbSNP
rs144366020 378 dbSNP
rs965677480 381 dbSNP
rs1350142001 385 dbSNP
rs540408961 393 dbSNP
rs1242706541 396 dbSNP
rs1378328728 398 dbSNP
rs1314923774 403 dbSNP
rs1449891300 407 dbSNP
rs750483889 409 dbSNP
rs921625387 414 dbSNP
rs192245683 418 dbSNP
rs529367575 422 dbSNP
rs549413233 444 dbSNP
rs555271982 454 dbSNP
rs758457026 464 dbSNP
rs1059833 470 dbSNP
rs148013145 473 dbSNP
rs1224229653 474 dbSNP
rs1384588128 485 dbSNP
rs562853120 498 dbSNP
rs915402264 508 dbSNP
rs780457399 509 dbSNP
rs747555344 515 dbSNP
rs1446658980 516 dbSNP
rs1259864458 518 dbSNP
rs1485209215 523 dbSNP
rs531705072 530 dbSNP
rs144725033 538 dbSNP
rs138363016 547 dbSNP
rs1226867081 551 dbSNP
rs573622077 554 dbSNP
rs924207277 561 dbSNP
rs1358993835 562 dbSNP
rs534116144 567 dbSNP
rs1429368664 570 dbSNP
rs1324367948 574 dbSNP
rs1213484349 579 dbSNP
rs1245306953 595 dbSNP
rs1056450953 602 dbSNP
rs1300991229 603 dbSNP
rs755459117 605 dbSNP
rs1481910225 606 dbSNP
rs1163937339 626 dbSNP
rs1475106940 628 dbSNP
rs1430297011 671 dbSNP
rs1371602023 672 dbSNP
rs781596713 674 dbSNP
rs895175682 676 dbSNP
rs1249274339 679 dbSNP
rs1012323234 680 dbSNP
rs1049617926 689 dbSNP
rs887569656 695 dbSNP
rs748511597 702 dbSNP
rs1218869352 711 dbSNP
rs1344414348 718 dbSNP
rs1281166801 721 dbSNP
rs142953770 722 dbSNP
rs774003203 723 dbSNP
rs146107881 724 dbSNP
rs1328074736 728 dbSNP
rs140134212 731 dbSNP
rs771648540 742 dbSNP
rs376416562 749 dbSNP
rs1355990637 750 dbSNP
rs774838793 752 dbSNP
rs1428815485 753 dbSNP
rs1197770055 755 dbSNP
rs1479198478 760 dbSNP
rs953198475 769 dbSNP
rs1204438902 785 dbSNP
rs201191165 788 dbSNP
rs989881631 797 dbSNP
rs556187881 798 dbSNP
rs968164453 799 dbSNP
rs1280936563 803 dbSNP
rs1220785766 814 dbSNP
rs1408059801 821 dbSNP
rs978217450 827 dbSNP
rs575753172 829 dbSNP
rs2664584 833 dbSNP
rs184263586 836 dbSNP
rs1333485116 839 dbSNP
rs924134966 843 dbSNP
rs538224257 848 dbSNP
rs1405694281 856 dbSNP
rs190724641 863 dbSNP
rs1416584428 864 dbSNP
rs939615966 866 dbSNP
rs1232832899 867 dbSNP
rs1469074719 874 dbSNP
rs1288187304 875 dbSNP
rs992854000 876 dbSNP
rs1309618105 877 dbSNP
rs577904269 878 dbSNP
rs540970334 881 dbSNP
rs948049137 883 dbSNP
rs1049150041 889 dbSNP
rs560627477 892 dbSNP
rs1309866573 904 dbSNP
rs940786225 911 dbSNP
rs1036180393 912 dbSNP
rs1481815212 920 dbSNP
rs1189469029 921 dbSNP
rs1418219430 935 dbSNP
rs181971830 962 dbSNP
rs997435582 964 dbSNP
rs1183036872 965 dbSNP
rs1179689389 968 dbSNP
rs1241129923 978 dbSNP
rs369668379 982 dbSNP
rs542869617 983 dbSNP
rs115177153 987 dbSNP
rs888749042 992 dbSNP
rs1169714393 996 dbSNP
rs1368653682 1000 dbSNP
rs1230063989 1001 dbSNP
rs776570396 1010 dbSNP
rs1288487358 1011 dbSNP
rs576618225 1014 dbSNP
rs768955837 1021 dbSNP
rs1299110576 1022 dbSNP
rs761644413 1028 dbSNP
rs1356109104 1029 dbSNP
rs1447651806 1042 dbSNP
rs531870391 1047 dbSNP
rs1166326929 1048 dbSNP
rs1423869950 1049 dbSNP
rs977180638 1055 dbSNP
rs765402004 1061 dbSNP
rs1031121254 1062 dbSNP
rs961165334 1066 dbSNP
rs750619457 1069 dbSNP
rs1221399113 1077 dbSNP
rs1487483856 1080 dbSNP
rs916834481 1082 dbSNP
rs1223929011 1084 dbSNP
rs948050073 1092 dbSNP
rs184516728 1098 dbSNP
rs11556820 1107 dbSNP
rs556331268 1108 dbSNP
rs1279254680 1126 dbSNP
rs1213560606 1128 dbSNP
rs1036484704 1130 dbSNP
rs1389273447 1131 dbSNP
rs1295791303 1134 dbSNP
rs1458031988 1135 dbSNP
rs901642937 1135 dbSNP
rs1353422768 1142 dbSNP
rs188983062 1151 dbSNP
rs1485057761 1152 dbSNP
rs1050340393 1161 dbSNP
rs889045504 1165 dbSNP
rs1431207124 1166 dbSNP
rs1243467867 1173 dbSNP
rs567464702 1174 dbSNP
rs1191699463 1175 dbSNP
rs1475509778 1176 dbSNP
rs142438379 1178 dbSNP
rs8787 1181 dbSNP
rs1320309006 1185 dbSNP
rs569393119 1191 dbSNP
rs538384130 1194 dbSNP
rs998527552 1195 dbSNP
rs1303781642 1197 dbSNP
rs1035402628 1206 dbSNP
rs960879684 1207 dbSNP
rs1014181980 1208 dbSNP
rs1413945013 1216 dbSNP
rs1466705402 1235 dbSNP
rs558129856 1246 dbSNP
rs544092525 1251 dbSNP
rs1347198478 1259 dbSNP
rs1431704190 1262 dbSNP
rs1023832878 1277 dbSNP
rs1464415814 1278 dbSNP
rs571663423 1287 dbSNP
rs970028449 1303 dbSNP
rs1199229081 1311 dbSNP
rs1363396285 1323 dbSNP
rs1237215969 1327 dbSNP
rs1176893745 1331 dbSNP
rs1459136560 1338 dbSNP
rs180863513 1352 dbSNP
rs1239091305 1361 dbSNP
rs1200100128 1367 dbSNP
rs985081926 1370 dbSNP
rs1343735409 1376 dbSNP
rs8356 1377 dbSNP
rs1285702319 1378 dbSNP
rs1447226931 1379 dbSNP
rs1307682128 1390 dbSNP
rs962046683 1395 dbSNP
rs1214563838 1400 dbSNP
rs1376986785 1411 dbSNP
rs1335410124 1416 dbSNP
rs1393941263 1434 dbSNP
rs1246030531 1437 dbSNP
rs753079360 1443 dbSNP
rs139011529 1446 dbSNP
rs1172971731 1461 dbSNP
rs1452742725 1464 dbSNP
rs1378455755 1472 dbSNP
rs1160381573 1494 dbSNP
rs2664577 1495 dbSNP
rs1440167168 1505 dbSNP
rs972104570 1507 dbSNP
rs1186875071 1509 dbSNP
rs1440942204 1510 dbSNP
rs1258494223 1511 dbSNP
rs923369230 1525 dbSNP
rs1488159666 1528 dbSNP
rs1469649485 1545 dbSNP
rs1284590158 1548 dbSNP
rs933140645 1554 dbSNP
rs1354976430 1561 dbSNP
rs1050666548 1562 dbSNP
rs1241931267 1582 dbSNP
rs1394377768 1583 dbSNP
rs1341934046 1591 dbSNP
rs910424425 1598 dbSNP
rs1381509272 1600 dbSNP
rs756459272 1602 dbSNP
rs947298278 1604 dbSNP
rs1476970183 1606 dbSNP
rs543186609 1609 dbSNP
rs1410168112 1612 dbSNP
rs13449 1614 dbSNP
rs902814929 1617 dbSNP
rs1370480117 1620 dbSNP
rs1188501022 1621 dbSNP
rs1477579219 1622 dbSNP
rs11556819 1624 dbSNP
rs998493444 1625 dbSNP
rs530180264 1629 dbSNP
rs576602221 1638 dbSNP
rs1158687911 1645 dbSNP
rs1056853019 1647 dbSNP
rs1284209015 1660 dbSNP
rs895541334 1660 dbSNP
rs777964039 1670 dbSNP
rs1217653601 1672 dbSNP
rs1337904124 1677 dbSNP
rs1012692824 1681 dbSNP
rs1386961449 1682 dbSNP
rs1349276675 1689 dbSNP
rs1024223067 1702 dbSNP
rs1403740305 1703 dbSNP
rs1392974173 1708 dbSNP
rs1163853127 1709 dbSNP
rs1465322253 1709 dbSNP
rs969581140 1710 dbSNP
rs1443538738 1714 dbSNP
rs1326940551 1718 dbSNP
rs1197419199 1719 dbSNP
rs1315723612 1719 dbSNP
rs144950386 1719 dbSNP
rs1478338535 1719 dbSNP
rs58754462 1719 dbSNP
rs1219075758 1726 dbSNP
rs1259566356 1726 dbSNP
rs1491056148 1727 dbSNP
rs547573221 1727 dbSNP
rs397767907 1728 dbSNP
rs60230203 1728 dbSNP
rs1060391 1729 dbSNP
rs1465137825 1729 dbSNP
rs536521359 1729 dbSNP
rs878962793 1729 dbSNP
rs1280801527 1731 dbSNP
rs1350753428 1732 dbSNP
rs1173073714 1733 dbSNP
rs774744131 1733 dbSNP
rs1398199209 1734 dbSNP
rs1424924865 1734 dbSNP
rs1479310258 1734 dbSNP
rs1491024882 1735 dbSNP
rs867369234 1735 dbSNP
rs1265812101 1736 dbSNP
rs761486189 1736 dbSNP
rs1016528015 1737 dbSNP
rs1345678026 1737 dbSNP
rs1389271549 1737 dbSNP
rs1491433714 1737 dbSNP
rs3208479 1737 dbSNP
rs397727628 1737 dbSNP
rs878937174 1737 dbSNP
rs1443235873 1738 dbSNP
rs58037333 1738 dbSNP
rs60995368 1739 dbSNP
rs1396271461 1740 dbSNP
rs1438311863 1740 dbSNP
rs1381636392 1741 dbSNP
rs1482741773 1741 dbSNP
rs1235352233 1742 dbSNP
rs1336732062 1742 dbSNP
rs1285301050 1743 dbSNP
rs1237872797 1745 dbSNP
rs75977206 1748 dbSNP
rs80060706 1749 dbSNP
rs1224382496 1765 dbSNP
rs1311601149 1765 dbSNP
rs1378787974 1781 dbSNP
rs1301304490 1786 dbSNP
rs1214116923 1797 dbSNP
rs1376451065 1812 dbSNP
rs1266355823 1813 dbSNP
rs1449796694 1821 dbSNP
rs1362961159 1830 dbSNP
rs1159244690 1832 dbSNP
rs1422703752 1835 dbSNP
rs1411250322 1838 dbSNP
rs1183231398 1841 dbSNP
rs1475290939 1844 dbSNP
rs745580135 1848 dbSNP
rs1234731684 1851 dbSNP
rs1214131950 1852 dbSNP
rs1489255503 1852 dbSNP
rs1470550167 1857 dbSNP
rs1286628203 1858 dbSNP
rs962015966 1860 dbSNP
rs1321194671 1863 dbSNP
rs1410064185 1871 dbSNP
rs1463174058 1877 dbSNP
rs545470627 1888 dbSNP
rs771609230 1889 dbSNP
rs923326691 1894 dbSNP
rs1342988982 1907 dbSNP
rs1166108382 1915 dbSNP
rs1457028583 1918 dbSNP
rs954955242 1921 dbSNP
rs1166213143 1927 dbSNP
rs550228087 1929 dbSNP
rs527649016 1930 dbSNP
rs1422434108 1932 dbSNP
rs1191298469 1933 dbSNP
rs910343145 1948 dbSNP
rs1331457166 1967 dbSNP
rs947224863 1968 dbSNP
rs1042927715 1969 dbSNP
rs1263783854 1970 dbSNP
rs924542090 1974 dbSNP
rs934605645 1984 dbSNP
rs1257634327 1986 dbSNP
rs1057181959 1990 dbSNP
rs1320441166 2002 dbSNP
rs866351400 2002 dbSNP
rs1296652867 2011 dbSNP
rs895524203 2013 dbSNP
rs746452252 2014 dbSNP
rs1044162194 2025 dbSNP
rs1440977722 2027 dbSNP
rs905324769 2060 dbSNP
rs1399168021 2066 dbSNP
rs14831 2066 dbSNP
rs1233446595 2072 dbSNP
rs1168094083 2076 dbSNP
rs1466804637 2079 dbSNP
rs1373449633 2089 dbSNP
rs886847951 2090 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202479. RNA binding protein: AGO2. Condition:S4_LV_29yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202477. RNA binding protein: AGO2. Condition:S2_LV_25yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Liver Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2550618. RNA binding protein: AGO2. Condition:Patient 1 Tumor 1 ...

- Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al., 2017, Molecular cell.

Article - Luna JM; Barajas JM; Teng KY; Sun HL; Moore et al.
- Molecular cell, 2017
MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. We observed a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to other genic and non-genic sites. Motif analysis of miR-122-dependent binding revealed a G-bulged motif in addition to canonical motifs. A large number of miR-122 targets were found to be species specific. Upregulation of several common mouse and human targets, most notably BCL9, predicted survival in HCC patients. These results broadly define the molecular consequences of miR-122 downregulation in hepatocellular carcinoma.
LinkOut: [PMID: 28735896]
CLIP-seq Support 1 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000353703.4 | 3UTR | GCGAUAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000353703.4 | 3UTR | GUGCGAUAAAAAAAAAAAAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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