pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol USP32   
Synonyms NY-REN-60, USP10
Description ubiquitin specific peptidase 32
Transcript NM_032582   
Expression
Putative miRNA Targets on USP32
3'UTR of USP32
(miRNA target sites are highlighted)
>USP32|NM_032582|3'UTR
   1 AGCTACCACTCTGGCTGCTAGACAGCTTGGCGGTGAGGGAGATGACTCCTTGTAGCTGACATTTGGCAAAAGCGTCACTG
  81 AAAGGCAAGCTAAATGTAGTTATTTTATCCTGTGGCCCTGAAGCACAAAATAAAAATTCTAATTAAAATAGTTAACTTTA
 161 AGAGTAGTAATCATTTTATTTTGAAGTCTCATACAAGCTCTCCGATAGAGAACTTTCAGGCAGATCCCACCATTAGCCTG
 241 TAAACAAAAGGTTTGGCACCAGCCACCTGGGACCAAATAAGAATTCAATTGTGCTTGTCCAGATATGAACAAATATGTAG
 321 TGAGTATAGAGTTTACCATAATCATAACAAATATTAAAGATTTCCTTGGAGTCAGAGTAAAAAACAAACAATTATAATGT
 401 TGTCTAGGGACGACATGATATGCTACCTCCTTTTTCCTGAAGTTTTATTCCATTATATTGACAAGATGGAGAAAGCAAGA
 481 TCACGAAGGTGTGCAAATGATTCTTAAGGCATGGACGAGGATTTTTCAATTTATTTTTTAAACTGTTTCCATACCCTTTC
 561 TTTGTCTTTCTTGCTTTTTGTTTTTGCCGTTGTATTTATGTTTGAGACACAACCAGTCATTGGTGGCAGGGGCATATAGT
 641 GGTCAGTCTGAAAGGGAGGCTCTCTTAAGAGCTGTGTGCCTTCCACCCAGAGCCTTGTGGGAGACCCAGTAGAAAGAAAC
 721 AGCATCCTGGGAAATCCAGCTACCATGGCCCTCCCAGTGGAGGCATCTTACATTTAGGATACTTCAAGTATCCTCAGAAA
 801 TGTATTCTGCACCCCCGGCCCCACCCATGCTGAGGGAAGGGGAGCAGTTGCCAATATTTGCACCATCTTCACATGCACCT
 881 GTTGCAACAAGAGCTTCTGGGAAGGTAAGTGGCATTGGAGCTAGATCACGTTTCACAATTAGTGGTTGTTCTTTTCTGTG
 961 TTTGTCTTGCACTTTAAAAAAGAGAGAACACATGCAAATGAACTTGCTTGTGTGTATTTGATGGCTCTAAGGGCTATAAA
1041 TTACAAACAAAACACATCCCAGACATTAGGAGTTCATAAGTGTATTTAATGAAATTGGTGGTTTTAGGAAGTCAACTTTA
1121 GTTTTGCTTTGTTTGCATGTCCACTAATTTTTTTATTTTGATATTTGTCTTTTTTTTAAATTTTACAGTAGTCATCGAAA
1201 GTTATGTTTCTTTGCTTACTTCATTTTTTTCTCTAATCAAGACTGGAACAAAAGTATAAATATTATTTATTTCAGGTAGC
1281 ATTTTTTTCGTGTAGTTTTTTAATATATACTTGAAGGAAATGTTTCACCTTATTTTTGGTCTTTGTTTATTCATTTAGAC
1361 CCTGCAAGTTGATTCTCATTAATTGTCAGATTCCACTACCCTTTCTTCCTCATAGATAGTAATTACCAATGTAACTAAGT
1441 ATTTGTGTTCTGATATCTGAGGCCAGTAACTATTAATATCTAGTTCTCAGAGCATTTGGAAAGGTTATCTTAAATGGCTA
1521 CCTAAATTGAAATCCTTTTCAGAAAAAATATAATTGCAAGTAGGTAGGACTGGCCTAAATTGTCTAATGTAATAAAGTCA
1601 GACAAAATGCATACTTTATAGTTTCAAGATTTTCAGTATATAAAATCTGTCCATTCCCATTAAAAAGTGGAAGATTTTAA
1681 ATAATTTCTTTACAGATGTTTTATTTAAGCAGGTAGCTCAATCTACTAATGTTGTTTGATCTGTGTTTGTTATACTGGTT
1761 GTAATTAATTTTTTTAATTCATGAACTAGCAGAAAATTTATTAAATTAACTATTAACTACATTCACCTTGTAAATTACTG
1841 TATAAAACTTGTTGACAATGCACTGACTTTAGAAAGATGTTAATGTACATAAATAGAGTGTAAATAAAATAGTGTTGATG
1921 TACCG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaguucCAGG-CGACACUUGUgc 5'
                |||| | | ||||||  
Target 5' gtgcttGTCCAGATATGAACAaa 3'
291 - 313 136.00 -10.70
2
miRNA  3' uaguuccaggcgacaCUUGUGc 5'
                         |||||| 
Target 5' actttaaaaaagagaGAACACa 3'
971 - 992 120.00 -6.40
3
miRNA  3' uaguuccAGGCGACACU-UGUGc 5'
                 | :|:| ||| |||| 
Target 5' ttgtattTATGTT-TGAGACACa 3'
590 - 611 114.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30507517 7 COSMIC
COSN30468712 32 COSMIC
COSN30171528 39 COSMIC
COSN30106200 80 COSMIC
COSN30499413 98 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1296434926 1 dbSNP
rs757632645 2 dbSNP
rs1309309187 7 dbSNP
rs376232070 8 dbSNP
rs566664608 9 dbSNP
rs756716309 11 dbSNP
rs1358583412 13 dbSNP
rs1353424910 14 dbSNP
rs752773156 21 dbSNP
rs1416337653 23 dbSNP
rs767715730 27 dbSNP
rs1170290439 28 dbSNP
rs373314363 29 dbSNP
rs370534709 31 dbSNP
rs376216867 32 dbSNP
rs1472764897 33 dbSNP
rs1443673560 41 dbSNP
rs762785759 42 dbSNP
rs542454947 52 dbSNP
rs1206718176 57 dbSNP
rs1421100518 61 dbSNP
rs998771799 65 dbSNP
rs767553931 66 dbSNP
rs759824012 67 dbSNP
rs112560951 74 dbSNP
rs770376590 75 dbSNP
rs1339136359 90 dbSNP
rs1404321307 99 dbSNP
rs1040210463 109 dbSNP
rs944775816 126 dbSNP
rs1364252998 128 dbSNP
rs910606536 129 dbSNP
rs1294887686 137 dbSNP
rs1324232887 140 dbSNP
rs1361821036 155 dbSNP
rs1306867449 156 dbSNP
rs1225236151 170 dbSNP
rs1261077745 174 dbSNP
rs1460697761 187 dbSNP
rs1216154284 190 dbSNP
rs1243496501 192 dbSNP
rs1445755923 194 dbSNP
rs766567474 203 dbSNP
rs184192869 204 dbSNP
rs1481072031 205 dbSNP
rs1433702945 206 dbSNP
rs543524798 217 dbSNP
rs1348755601 218 dbSNP
rs1163636908 221 dbSNP
rs533166811 226 dbSNP
rs557743438 236 dbSNP
rs1160206403 238 dbSNP
rs1347204122 240 dbSNP
rs534548617 253 dbSNP
rs1418793206 255 dbSNP
rs1297705012 259 dbSNP
rs972753155 262 dbSNP
rs1251881125 263 dbSNP
rs567216372 264 dbSNP
rs1487564071 269 dbSNP
rs181554413 289 dbSNP
rs536878043 290 dbSNP
rs1490918308 306 dbSNP
rs1284068297 307 dbSNP
rs928154677 312 dbSNP
rs1317240962 317 dbSNP
rs982203478 320 dbSNP
rs1202306689 326 dbSNP
rs773574606 328 dbSNP
rs1267386079 330 dbSNP
rs1279661718 334 dbSNP
rs1477954483 337 dbSNP
rs1178173302 348 dbSNP
rs1410579659 354 dbSNP
rs1399228638 360 dbSNP
rs1158260545 372 dbSNP
rs8067625 375 dbSNP
rs1063884 378 dbSNP
rs1366798035 384 dbSNP
rs1023169820 395 dbSNP
rs1303295969 399 dbSNP
rs1330475855 411 dbSNP
rs748631178 412 dbSNP
rs1281109167 414 dbSNP
rs991249251 416 dbSNP
rs1063885 421 dbSNP
rs1174629899 422 dbSNP
rs1297133476 439 dbSNP
rs1453518576 444 dbSNP
rs776343929 446 dbSNP
rs1292042426 450 dbSNP
rs1032651202 455 dbSNP
rs1219633989 457 dbSNP
rs998793493 463 dbSNP
rs768267908 468 dbSNP
rs550668153 481 dbSNP
rs1429181887 493 dbSNP
rs528855988 496 dbSNP
rs550863022 503 dbSNP
rs531045856 506 dbSNP
rs1490844900 511 dbSNP
rs1018798074 516 dbSNP
rs769846466 517 dbSNP
rs571605075 520 dbSNP
rs1486301107 522 dbSNP
rs1262324951 528 dbSNP
rs1446622536 529 dbSNP
rs1161781120 540 dbSNP
rs1390061757 540 dbSNP
rs1410510557 546 dbSNP
rs1330792745 550 dbSNP
rs1207743847 551 dbSNP
rs1445776837 554 dbSNP
rs1315406867 557 dbSNP
rs1384571813 564 dbSNP
rs1243283002 570 dbSNP
rs1283143400 581 dbSNP
rs1339461733 588 dbSNP
rs1008769954 589 dbSNP
rs888949457 593 dbSNP
rs1050966030 594 dbSNP
rs930732186 608 dbSNP
rs779577945 611 dbSNP
rs1462853695 619 dbSNP
rs1322822956 623 dbSNP
rs899173627 627 dbSNP
rs1036341537 631 dbSNP
rs1283769138 636 dbSNP
rs940946798 637 dbSNP
rs1464991387 649 dbSNP
rs1337194091 657 dbSNP
rs928184248 662 dbSNP
rs1450087105 664 dbSNP
rs1337701989 674 dbSNP
rs144544967 678 dbSNP
rs1326587172 681 dbSNP
rs561750876 687 dbSNP
rs772605028 694 dbSNP
rs1267852253 701 dbSNP
rs1382473472 703 dbSNP
rs1218526189 709 dbSNP
rs748503707 715 dbSNP
rs948261461 716 dbSNP
rs1326084116 719 dbSNP
rs916742636 726 dbSNP
rs528458005 729 dbSNP
rs991661954 745 dbSNP
rs957122652 747 dbSNP
rs1261070394 753 dbSNP
rs1033097462 754 dbSNP
rs1177054698 756 dbSNP
rs977051168 760 dbSNP
rs559257264 773 dbSNP
rs1468044070 779 dbSNP
rs1171724638 782 dbSNP
rs747452085 788 dbSNP
rs1385254969 792 dbSNP
rs189303136 797 dbSNP
rs1315665611 802 dbSNP
rs1339245090 803 dbSNP
rs375650759 812 dbSNP
rs371054189 816 dbSNP
rs879505837 817 dbSNP
rs563512437 823 dbSNP
rs1326192389 825 dbSNP
rs185712343 826 dbSNP
rs1255720714 829 dbSNP
rs1351711190 851 dbSNP
rs73320971 861 dbSNP
rs1284045132 866 dbSNP
rs1488002495 871 dbSNP
rs1200156222 872 dbSNP
rs1270982569 873 dbSNP
rs1431325160 874 dbSNP
rs1192537201 878 dbSNP
rs536511503 884 dbSNP
rs1429401619 900 dbSNP
rs1455064349 908 dbSNP
rs1156430668 912 dbSNP
rs1359414600 913 dbSNP
rs1264123877 919 dbSNP
rs1304368853 919 dbSNP
rs1179909204 925 dbSNP
rs1460658445 929 dbSNP
rs1347960719 930 dbSNP
rs1385555123 938 dbSNP
rs1301063541 939 dbSNP
rs1336712504 943 dbSNP
rs564019944 944 dbSNP
rs1241529614 956 dbSNP
rs1307355541 958 dbSNP
rs1353186532 970 dbSNP
rs142000332 979 dbSNP
rs572051367 981 dbSNP
rs888975057 986 dbSNP
rs1487489852 987 dbSNP
rs1209146976 992 dbSNP
rs1205438524 997 dbSNP
rs1371622489 1012 dbSNP
rs1420646504 1029 dbSNP
rs1176472018 1030 dbSNP
rs528799200 1032 dbSNP
rs564336325 1045 dbSNP
rs1250316660 1049 dbSNP
rs1227499719 1066 dbSNP
rs1164964994 1070 dbSNP
rs995348924 1075 dbSNP
rs555375889 1080 dbSNP
rs867516127 1082 dbSNP
rs1456892386 1093 dbSNP
rs1293455533 1098 dbSNP
rs145944956 1103 dbSNP
rs1393517611 1108 dbSNP
rs1310050357 1109 dbSNP
rs1376482529 1113 dbSNP
rs575802300 1115 dbSNP
rs574212551 1119 dbSNP
rs1036777267 1135 dbSNP
rs1337769093 1143 dbSNP
rs557536132 1145 dbSNP
rs1319982868 1146 dbSNP
rs1471271892 1148 dbSNP
rs1251817786 1149 dbSNP
rs1004872020 1154 dbSNP
rs1167481828 1162 dbSNP
rs1196549104 1169 dbSNP
rs1237297326 1169 dbSNP
rs192661891 1177 dbSNP
rs1046652397 1178 dbSNP
rs1375727074 1178 dbSNP
rs533028007 1178 dbSNP
rs1422733878 1183 dbSNP
rs1170464931 1190 dbSNP
rs1374168352 1195 dbSNP
rs1375012510 1196 dbSNP
rs1185624051 1197 dbSNP
rs1443809905 1205 dbSNP
rs1453732576 1206 dbSNP
rs948280108 1209 dbSNP
rs201896076 1215 dbSNP
rs1185176276 1217 dbSNP
rs916754450 1222 dbSNP
rs1216687399 1231 dbSNP
rs1309217804 1231 dbSNP
rs116563086 1236 dbSNP
rs1257241336 1237 dbSNP
rs1053921186 1242 dbSNP
rs199668486 1247 dbSNP
rs935760093 1249 dbSNP
rs925759410 1251 dbSNP
rs977167216 1260 dbSNP
rs1186631053 1262 dbSNP
rs1263185013 1264 dbSNP
rs1263344866 1265 dbSNP
rs967060462 1265 dbSNP
rs1244845734 1268 dbSNP
rs1359683518 1274 dbSNP
rs911547903 1275 dbSNP
rs1357664365 1279 dbSNP
rs1447519693 1279 dbSNP
rs377409814 1280 dbSNP
rs1289561031 1289 dbSNP
rs373143266 1290 dbSNP
rs953297987 1292 dbSNP
rs1334518947 1297 dbSNP
rs1277494050 1301 dbSNP
rs187688009 1302 dbSNP
rs1225142170 1303 dbSNP
rs1276197040 1305 dbSNP
rs1392055451 1307 dbSNP
rs1216034000 1310 dbSNP
rs1398673818 1321 dbSNP
rs148043947 1329 dbSNP
rs963534426 1354 dbSNP
rs1192224132 1365 dbSNP
rs1263123306 1368 dbSNP
rs1386077979 1383 dbSNP
rs1014999558 1385 dbSNP
rs1165308316 1390 dbSNP
rs1437518617 1395 dbSNP
rs1363169584 1406 dbSNP
rs1193318082 1408 dbSNP
rs1182388574 1411 dbSNP
rs184564730 1426 dbSNP
rs906558089 1429 dbSNP
rs1362619982 1431 dbSNP
rs1264716768 1436 dbSNP
rs1046360682 1437 dbSNP
rs866951613 1440 dbSNP
rs1012918026 1444 dbSNP
rs1490431630 1451 dbSNP
rs1366145768 1452 dbSNP
rs895369282 1458 dbSNP
rs565758119 1461 dbSNP
rs1248647120 1462 dbSNP
rs1311011973 1478 dbSNP
rs1350982914 1480 dbSNP
rs936894230 1481 dbSNP
rs1348920144 1492 dbSNP
rs1279516932 1509 dbSNP
rs574728202 1516 dbSNP
rs548930141 1517 dbSNP
rs191664179 1531 dbSNP
rs1178079110 1533 dbSNP
rs1382423782 1540 dbSNP
rs1053535 1560 dbSNP
rs945748421 1562 dbSNP
rs1053536 1570 dbSNP
rs1366246577 1572 dbSNP
rs1404405357 1574 dbSNP
rs1321498209 1575 dbSNP
rs1349159244 1579 dbSNP
rs911578675 1580 dbSNP
rs1053537 1582 dbSNP
rs1452333584 1591 dbSNP
rs1366432386 1598 dbSNP
rs987095284 1603 dbSNP
rs1238937148 1607 dbSNP
rs369438586 1613 dbSNP
rs953426390 1618 dbSNP
rs1357837156 1628 dbSNP
rs1230599543 1632 dbSNP
rs563387301 1635 dbSNP
rs921903668 1656 dbSNP
rs1456645385 1657 dbSNP
rs973723905 1659 dbSNP
rs879104765 1662 dbSNP
rs35840195 1667 dbSNP
rs1158909874 1669 dbSNP
rs1386008904 1670 dbSNP
rs1471153083 1675 dbSNP
rs1473817975 1697 dbSNP
rs1161480063 1698 dbSNP
rs963264998 1713 dbSNP
rs1014696605 1730 dbSNP
rs1375858964 1731 dbSNP
rs1198076513 1736 dbSNP
rs376946656 1736 dbSNP
rs1480447822 1743 dbSNP
rs1172609577 1752 dbSNP
rs1270628462 1757 dbSNP
rs757228324 1762 dbSNP
rs187204504 1763 dbSNP
rs970749585 1774 dbSNP
rs1446029766 1783 dbSNP
rs703790 1791 dbSNP
rs182867322 1793 dbSNP
rs1283045253 1795 dbSNP
rs1356308817 1797 dbSNP
rs532970943 1798 dbSNP
rs1260456481 1803 dbSNP
rs1284065891 1808 dbSNP
rs1198332557 1812 dbSNP
rs1257136993 1813 dbSNP
rs1444298656 1820 dbSNP
rs1024941886 1826 dbSNP
rs1012285688 1827 dbSNP
rs1475730494 1830 dbSNP
rs1195739092 1840 dbSNP
rs1206072943 1858 dbSNP
rs553374312 1896 dbSNP
rs1281855785 1911 dbSNP
rs1176817099 1915 dbSNP
rs564238541 1924 dbSNP
rs190826813 1925 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000300896.4 | 3UTR | UUGUCUUGCACUUUAAAAAAGAGAGAAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors 0.299 8.2e-3 0.258 2.0e-2 64 Click to see details
GSE42095 Differentiated embryonic stem cells 0.459 1.4e-2 0.110 3.1e-1 23 Click to see details
GSE32688 Pancreatic cancer 0.361 2.1e-2 0.344 2.7e-2 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.319 6.4e-2 0.280 9.3e-2 24 Click to see details
GSE17498 Multiple myeloma 0.227 7.9e-2 0.216 9.0e-2 40 Click to see details
GSE28544 Breast cancer 0.244 1.3e-1 0.178 2.0e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.216 1.5e-1 0.199 1.7e-1 25 Click to see details
GSE19350 CNS germ cell tumors -0.157 3.1e-1 -0.070 4.1e-1 12 Click to see details
GSE38226 Liver fibrosis 0.105 3.3e-1 0.220 1.7e-1 21 Click to see details
GSE28260 Renal cortex and medulla -0.104 3.7e-1 0.099 3.7e-1 13 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.043 4.3e-1 -0.782 2.3e-5 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.043 4.3e-1 -0.782 2.3e-5 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
-0.043 4.3e-1 -0.782 2.3e-5 20 Click to see details
-0.043 4.3e-1 -0.782 2.3e-5 20 Click to see details
-0.043 4.3e-1 -0.782 2.3e-5 20 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission