pre-miRNA Information
pre-miRNA hsa-mir-4753   
Genomic Coordinates chr1: 235190034 - 235190116
Description Homo sapiens miR-4753 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4753-5p
Sequence 10| CAAGGCCAAAGGAAGAGAACAG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs547986869 3 dbSNP
rs1007787337 7 dbSNP
rs1224263160 12 dbSNP
rs1256249071 13 dbSNP
rs1484015538 14 dbSNP
rs535678819 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TCF7L2   
Synonyms TCF-4, TCF4
Description transcription factor 7 like 2
Transcript NM_001146283   
Other Transcripts NM_001146274 , NM_001146284 , NM_001146285 , NM_001146286 , NM_030756   
Expression
Putative miRNA Targets on TCF7L2
3'UTR of TCF7L2
(miRNA target sites are highlighted)
>TCF7L2|NM_001146283|3'UTR
   1 ATTCGCCTCCCCCCTCCCCGAACCTGCTAGGCTCCCCTCCCCGAGACGCCAAGTCACAGACTGAGCAGACCCAGCCTCTG
  81 TCGCTGTCCCTGAAGCCCGACCCCCTGGCCCACCTGTCCATGATGCCTCCGCCACCCGCCCTCCTGCTCGCTGAGGCCAC
 161 CCACAAGGCCTCCGCCCTCTGTCCCAACGGGGCCCTGGACCTGCCCCCAGCCGCTTTGCAGCCTGCCGCCCCCTCCTCAT
 241 CAATTGCACAGCCGTCGACTTCTTCCTTACATTCCCACAGCTCCCTGGCCGGGACCCAGCCCCAGCCGCTGTCGCTCGTC
 321 ACCAAGTCTTTAGAATAGCTTTAGCGTCGTGAACCCCGCTGCTTTGTTTATGGTTTTGTTTCACTTTTCTTAATTTGCCC
 401 CCCACCCCCACCTTGAAAGGTTTTGTTTTGTACTCTCTTAATTTTGTGCCATGTGGCTACATTAGTTGATGTTTATCGAG
 481 TTCATTGGTCAATATTTGACCCATTCTTATTTCAATTTCTCCTTTTAAATATGTAGATGAGAGAAGAACCTCATGATTCT
 561 ACCAAAATTTTTATCAACAGCTGTTTAAAGTCTTTGTAGCGTTTAAAAAATATATATATATACATAACTGTTATGTAGTT
 641 CGGATAGCTTAGTTTTAAAAGACTGATTAAAAAACAAAAAGAAAAAAAAAGCAATTTTGAAGCAGCCCTCCAGAAGGAGT
 721 TGGTTCTGTATTATTTGTATTAAATACGAGCTTGCGAACCAATCATTTTACATCTGGTTTTTAAACCGTAAGGGCACCAT
 801 GAATGCAGTGCCGTTACTTTTTTTTTTTTTTTCTGTGTGAAACAACTCTTATTGTGATGTTACTTGTTATTGTTTAAATG
 881 TACAGAAACAAAGGGTAAAAATGTGTTAATATACCTTGTTCCATGGTGTTGTTCTTTTGGGGGGAGGGGACGCTACTCAA
 961 CACTTAATAGAATCACAACGCTGTTGGGCCAGTAGTATTTATTGCTTTAGAGATTGCTTGTCGTACCTGTATGTCGTCCC
1041 TTTTTAAATATGTTTTCCTTTTTCTTGAAACTGTATAAAGTTTTTTTCCCCCTTAGCATAAGCATCTTATATATAACAAC
1121 TCATTTGTACAAGGTTTTTAAGTTTATATATAAAATGTGTATATATATTTTTGTTTCCCCTTTTTGACTTTTTTTTTTCT
1201 GTATGAAACCCAGATGTCACCAAATGGACATTAATAGTTGCATTAAGGATCAGTAGCATTAACAAAAGTTGCTTTAAAAG
1281 CCATTATGTAAAACAAGACTTGAAAATGAGTGAGGGAATTTTAGCGACACTGTCTGAGCAGCAGTGGGAACCATCTTCGT
1361 TTCCCCTTTGAACTCCCAGTGGGATGCCCTACCCTGCGCCCTTAGGACCCGGACTGACCGTGTACAAAACTTTACGTGCC
1441 AAAATTCTCAGTGAATTTAGCTTTCTCCCTCTTTTTGATGCTGTAATTTTTGTTCATCATGTTTTGCTGTGATGTTACAT
1521 AGGTAGATTTGTATGTAGTTTTAATGTCACCTATAACAAAATGTGTTTGGTAGCAGATTGTCCAGAAAGCATTTTAAATG
1601 AAGAGGTATAAACCCTTAAGGGCCAAAATTCTGTATATTAGATTACTCTTAAACGAAAAACCAGCTGCCGCTTTTATGTA
1681 CACATATTACATACGAGTAGGCAGCAGACTTTAAAAATAAAAAAAACCTAGGCATGTTGATGTTGCAAAATGCTGTATAA
1761 AGCTGAAACCTGTTCATTCAGTGCCATTGTAGTTGACATGAAGCGATTGTAAAACTGTCTCCGATTTTTCTCTGGTTTAT
1841 TAAAATGCTAACTATAACATTTTTTGTGAATACTTTGAATGTTTCCTAACAGTTGTGATGTTACTGTTCCGTTTTATGCT
1921 CTTATTCCAAGTTCATTTTTAATGGTTTGGAAGCCATTTTTGTAATGAATAAATGTTCATGCTGTACAGTATCTGTAGCA
2001 TGCCGTTCTGGATTAATAAAAGCAACTTAGTATGTGCAGATAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gacAAGAGAAGGAAACCGGAAc 5'
             | ||:| ::| |||::|| 
Target 5' cgcTGCTTTGTTTATGGTTTTg 3'
357 - 378 127.00 -14.40
2
miRNA  3' gacAAGAGAAGG----AAACCGGAAc 5'
             ||: :||||    |||| |:|| 
Target 5' attTTTGTTTCCCCTTTTTGACTTTt 3'
1167 - 1192 117.00 -7.10
3
miRNA  3' gaCAA-GAGAAGG---AA-ACCGGAAc 5'
            ||| || ||||   || || :||| 
Target 5' atGTTACTGTTCCGTTTTATGCTCTTa 3'
1898 - 1924 116.00 -10.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
788108 13 ClinVar
771436 14 ClinVar
789033 14 ClinVar
719283 15 ClinVar
752295 39 ClinVar
717937 216 ClinVar
741522 223 ClinVar
780910 283 ClinVar
COSM914879 5 COSMIC
COSM4011663 6 COSMIC
COSM7739928 6 COSMIC
COSM1703039 10 COSMIC
COSM5893517 11 COSMIC
COSM1579626 13 COSMIC
COSM4467358 13 COSMIC
COSM6798595 15 COSMIC
COSM9164122 15 COSMIC
COSM914881 16 COSMIC
COSM3866510 19 COSMIC
COSM3434175 20 COSMIC
COSM1345861 21 COSMIC
COSM9832119 22 COSMIC
COSM9852338 26 COSMIC
COSM9852053 34 COSMIC
COSM7932749 35 COSMIC
COSM3434177 36 COSMIC
COSM6014092 38 COSMIC
COSM3434179 42 COSMIC
COSM6926890 43 COSMIC
COSM2053361 44 COSMIC
COSM5765164 44 COSMIC
COSM9371089 45 COSMIC
COSM8266131 49 COSMIC
COSM9815765 52 COSMIC
COSM3747131 53 COSMIC
COSM8263334 72 COSMIC
COSM7561108 84 COSMIC
COSM9635271 90 COSMIC
COSM9832123 92 COSMIC
COSM6798565 99 COSMIC
COSM4392960 100 COSMIC
COSM7629523 100 COSMIC
COSM5969648 102 COSMIC
COSM4599994 104 COSMIC
COSM4011665 109 COSMIC
COSM9677538 119 COSMIC
COSM8852988 124 COSMIC
COSM6798605 131 COSMIC
COSM2053365 132 COSMIC
COSM2053367 138 COSMIC
COSM8814402 139 COSMIC
COSM9456354 141 COSMIC
COSM9832126 148 COSMIC
COSM343391 154 COSMIC
COSM9832129 159 COSMIC
COSM9832132 165 COSMIC
COSM4011667 174 COSMIC
COSM8498365 176 COSMIC
COSM6014094 180 COSMIC
COSM2053371 188 COSMIC
COSM6222845 189 COSMIC
COSM7233188 194 COSMIC
COSM9832135 225 COSMIC
COSM3985418 228 COSMIC
COSM9832138 228 COSMIC
COSM2053375 230 COSMIC
COSM5593403 231 COSMIC
COSM2053373 234 COSMIC
COSM9832141 234 COSMIC
COSM7265190 238 COSMIC
COSM3414689 240 COSMIC
COSM1579279 242 COSMIC
COSM8309047 244 COSMIC
COSM7532046 251 COSMIC
COSM8778312 252 COSMIC
COSM7255463 256 COSMIC
COSM6798544 272 COSMIC
COSM7617276 277 COSMIC
COSM9552000 284 COSMIC
COSM4767775 286 COSMIC
COSM6065140 289 COSMIC
COSM6798568 292 COSMIC
COSM3866512 303 COSMIC
COSM6967187 308 COSMIC
COSM6570530 309 COSMIC
COSM3741491 314 COSMIC
COSM4011669 315 COSMIC
COSM6944204 319 COSMIC
COSM7564153 323 COSMIC
COSM5360250 329 COSMIC
COSN31586920 346 COSMIC
COSN26998129 349 COSMIC
COSN26998130 350 COSMIC
COSN31609853 352 COSMIC
COSN30134417 358 COSMIC
COSN30644902 404 COSMIC
COSN511089 404 COSMIC
COSN30193589 408 COSMIC
COSN391154 412 COSMIC
COSN25659904 431 COSMIC
COSN31662316 546 COSMIC
COSN24964825 551 COSMIC
COSN31592752 610 COSMIC
COSN31635627 622 COSMIC
COSN1471822 773 COSMIC
COSN20092195 818 COSMIC
COSN20107556 833 COSMIC
COSN28202176 839 COSMIC
COSN23369649 1199 COSMIC
COSN29633586 1199 COSMIC
COSN8149531 1272 COSMIC
COSN20479960 1331 COSMIC
COSN25672478 1435 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1356500208 2 dbSNP
rs1318831223 3 dbSNP
rs1315096687 4 dbSNP
rs773530340 5 dbSNP
rs760999129 6 dbSNP
rs970148079 7 dbSNP
rs779651618 8 dbSNP
rs748822481 9 dbSNP
rs768101780 9 dbSNP
rs766781345 10 dbSNP
rs777115170 11 dbSNP
rs755287177 12 dbSNP
rs201257936 13 dbSNP
rs77673441 14 dbSNP
rs149031135 15 dbSNP
rs754884239 16 dbSNP
rs202133956 17 dbSNP
rs896587959 18 dbSNP
rs573425555 20 dbSNP
rs771614599 21 dbSNP
rs1265975206 22 dbSNP
rs772831726 23 dbSNP
rs746725245 24 dbSNP
rs771215921 26 dbSNP
rs1472170538 29 dbSNP
rs1156666266 32 dbSNP
rs1347241075 33 dbSNP
rs776990496 34 dbSNP
rs760036701 35 dbSNP
rs765693671 36 dbSNP
rs776105589 37 dbSNP
rs201460379 39 dbSNP
rs1350391597 41 dbSNP
rs151216935 42 dbSNP
rs375657594 43 dbSNP
rs766219492 44 dbSNP
rs372584799 48 dbSNP
rs138649767 49 dbSNP
rs752731332 54 dbSNP
rs58719567 55 dbSNP
rs757894645 56 dbSNP
rs1269591568 63 dbSNP
rs777266430 64 dbSNP
rs746604692 66 dbSNP
rs770588623 70 dbSNP
rs781575767 71 dbSNP
rs375237374 75 dbSNP
rs1164292367 78 dbSNP
rs770242240 83 dbSNP
rs368142604 84 dbSNP
rs1303828031 89 dbSNP
rs1042343479 91 dbSNP
rs1323784944 93 dbSNP
rs1048669118 95 dbSNP
rs1370556184 96 dbSNP
rs185631836 97 dbSNP
rs774587800 98 dbSNP
rs76249005 99 dbSNP
rs534110993 100 dbSNP
rs1193915978 101 dbSNP
rs759234509 102 dbSNP
rs765140709 103 dbSNP
rs1356807409 104 dbSNP
rs752575439 106 dbSNP
rs1291783480 107 dbSNP
rs758342453 109 dbSNP
rs777213297 110 dbSNP
rs997106736 111 dbSNP
rs1234421276 112 dbSNP
rs1207216340 113 dbSNP
rs1352007739 117 dbSNP
rs1036930478 118 dbSNP
rs773999824 119 dbSNP
rs751097280 120 dbSNP
rs1241598518 121 dbSNP
rs756799314 122 dbSNP
rs1164302963 126 dbSNP
rs1389572207 127 dbSNP
rs780686355 128 dbSNP
rs761454250 131 dbSNP
rs780741000 131 dbSNP
rs1173115336 132 dbSNP
rs371338610 134 dbSNP
rs1447835317 136 dbSNP
rs780472490 138 dbSNP
rs747331351 139 dbSNP
rs201155099 140 dbSNP
rs1315163531 141 dbSNP
rs1363776062 142 dbSNP
rs1212262225 143 dbSNP
rs749757425 147 dbSNP
rs769309826 150 dbSNP
rs774534267 151 dbSNP
rs1260952895 154 dbSNP
rs962376634 155 dbSNP
rs1462838841 157 dbSNP
rs1306744804 158 dbSNP
rs375945855 159 dbSNP
rs1190066540 161 dbSNP
rs1247529463 163 dbSNP
rs773296137 164 dbSNP
rs1475470614 165 dbSNP
rs1188336447 169 dbSNP
rs1243163348 172 dbSNP
rs761028094 174 dbSNP
rs1414332733 175 dbSNP
rs1174743549 179 dbSNP
rs764880064 180 dbSNP
rs752508884 181 dbSNP
rs1285830548 185 dbSNP
rs1337022515 187 dbSNP
rs762832310 188 dbSNP
rs562824219 189 dbSNP
rs368560561 190 dbSNP
rs1362581606 191 dbSNP
rs756746261 192 dbSNP
rs372869035 193 dbSNP
rs1325371664 194 dbSNP
rs749975791 197 dbSNP
rs1000300298 200 dbSNP
rs1033573031 202 dbSNP
rs1218044970 204 dbSNP
rs1242715082 205 dbSNP
rs755806253 206 dbSNP
rs780234613 207 dbSNP
rs749702260 209 dbSNP
rs1313191744 210 dbSNP
rs150354863 213 dbSNP
rs529966412 214 dbSNP
rs191419844 216 dbSNP
rs747148769 220 dbSNP
rs1410014105 222 dbSNP
rs147601829 223 dbSNP
rs776874056 224 dbSNP
rs945443027 226 dbSNP
rs73362229 228 dbSNP
rs1189031682 229 dbSNP
rs763934346 229 dbSNP
rs369554727 230 dbSNP
rs1223953247 231 dbSNP
rs766880832 232 dbSNP
rs749972572 233 dbSNP
rs147059345 236 dbSNP
rs1285079472 237 dbSNP
rs771172533 239 dbSNP
rs1308135107 240 dbSNP
rs1054377179 241 dbSNP
rs899775528 244 dbSNP
rs540099279 245 dbSNP
rs1216878382 249 dbSNP
rs755384168 252 dbSNP
rs779491224 254 dbSNP
rs748602828 255 dbSNP
rs1468304465 257 dbSNP
rs777670924 258 dbSNP
rs1408225958 260 dbSNP
rs1423508300 261 dbSNP
rs1301880553 264 dbSNP
rs113907149 270 dbSNP
rs747078789 271 dbSNP
rs771386581 272 dbSNP
rs1405418616 274 dbSNP
rs770962902 275 dbSNP
rs1442566389 279 dbSNP
rs776839601 279 dbSNP
rs1355771500 280 dbSNP
rs138340674 281 dbSNP
rs199967681 282 dbSNP
rs147841431 283 dbSNP
rs1358976490 284 dbSNP
rs1243952836 285 dbSNP
rs1293961103 287 dbSNP
rs768373644 288 dbSNP
rs774145012 289 dbSNP
rs371235565 290 dbSNP
rs761607292 291 dbSNP
rs375473698 292 dbSNP
rs1182954986 293 dbSNP
rs760212486 294 dbSNP
rs766048650 295 dbSNP
rs753538995 296 dbSNP
rs1386506484 297 dbSNP
rs759270464 301 dbSNP
rs1166838736 302 dbSNP
rs1003928208 308 dbSNP
rs765643411 309 dbSNP
rs149556542 314 dbSNP
rs1329289853 315 dbSNP
rs143411121 318 dbSNP
rs752060378 319 dbSNP
rs1044349184 320 dbSNP
rs757352157 325 dbSNP
rs1033924254 327 dbSNP
rs200948170 330 dbSNP
rs746031799 332 dbSNP
rs188333249 334 dbSNP
rs770026114 336 dbSNP
rs778640227 341 dbSNP
rs200117101 343 dbSNP
rs1278288341 344 dbSNP
rs771813287 345 dbSNP
rs368555957 346 dbSNP
rs760599810 347 dbSNP
rs202158086 349 dbSNP
rs540243279 350 dbSNP
rs1459958193 353 dbSNP
rs1371329072 354 dbSNP
rs759221293 355 dbSNP
rs141448155 358 dbSNP
rs201172396 358 dbSNP
rs764432801 359 dbSNP
rs1405025213 360 dbSNP
rs757774260 361 dbSNP
rs925412730 363 dbSNP
rs1056877 366 dbSNP
rs1487428472 370 dbSNP
rs368024370 371 dbSNP
rs756227318 375 dbSNP
rs780302754 379 dbSNP
rs1264809555 385 dbSNP
rs1449922830 398 dbSNP
rs529913198 398 dbSNP
rs1318542093 399 dbSNP
rs1306597336 400 dbSNP
rs542131424 401 dbSNP
rs114631541 403 dbSNP
rs1051028657 404 dbSNP
rs1304348129 405 dbSNP
rs975003740 409 dbSNP
rs890956054 410 dbSNP
rs1327542059 411 dbSNP
rs1205894414 414 dbSNP
rs1157068978 420 dbSNP
rs1419404948 422 dbSNP
rs1395928748 426 dbSNP
rs1201021145 427 dbSNP
rs1431535996 431 dbSNP
rs1266546288 433 dbSNP
rs1187083998 434 dbSNP
rs1489139141 437 dbSNP
rs939873554 438 dbSNP
rs984220094 440 dbSNP
rs1348082975 441 dbSNP
rs1282048740 442 dbSNP
rs1461251868 447 dbSNP
rs1036763727 449 dbSNP
rs1234640836 450 dbSNP
rs909622840 453 dbSNP
rs1296668298 455 dbSNP
rs759564727 458 dbSNP
rs771838330 459 dbSNP
rs1376244249 470 dbSNP
rs1405992337 471 dbSNP
rs995281157 472 dbSNP
rs568649824 478 dbSNP
rs1377193030 479 dbSNP
rs1171048846 480 dbSNP
rs1478723831 492 dbSNP
rs1260953392 511 dbSNP
rs775165558 516 dbSNP
rs1428588505 517 dbSNP
rs1468149910 519 dbSNP
rs949948787 522 dbSNP
rs1343659749 525 dbSNP
rs1251452744 542 dbSNP
rs1228987098 544 dbSNP
rs1330359932 547 dbSNP
rs1354631813 550 dbSNP
rs1320554551 557 dbSNP
rs1044275172 561 dbSNP
rs1399742670 564 dbSNP
rs905817021 569 dbSNP
rs1196763962 577 dbSNP
rs536179485 584 dbSNP
rs936008859 593 dbSNP
rs1033741213 598 dbSNP
rs1394572188 600 dbSNP
rs1054904359 602 dbSNP
rs894813299 603 dbSNP
rs1010743535 605 dbSNP
rs1014222727 605 dbSNP
rs369882395 610 dbSNP
rs563095246 610 dbSNP
rs996369754 610 dbSNP
rs781405798 612 dbSNP
rs748310188 615 dbSNP
rs1441418746 621 dbSNP
rs952429331 622 dbSNP
rs71483172 628 dbSNP
rs983800137 633 dbSNP
rs1017013174 635 dbSNP
rs978254915 637 dbSNP
rs1256687620 638 dbSNP
rs1032483486 642 dbSNP
rs568854792 643 dbSNP
rs539124719 644 dbSNP
rs566040972 650 dbSNP
rs1308014560 653 dbSNP
rs878896611 664 dbSNP
rs1203828317 676 dbSNP
rs1398266409 680 dbSNP
rs1330579223 681 dbSNP
rs949875743 682 dbSNP
rs979939603 682 dbSNP
rs974855905 683 dbSNP
rs1490899037 689 dbSNP
rs1363979895 690 dbSNP
rs935919763 691 dbSNP
rs548066191 692 dbSNP
rs773142752 694 dbSNP
rs1437259258 695 dbSNP
rs557438910 707 dbSNP
rs921891048 711 dbSNP
rs1267884836 713 dbSNP
rs1054428642 714 dbSNP
rs572656887 721 dbSNP
rs946127519 723 dbSNP
rs1356138888 727 dbSNP
rs1186006540 744 dbSNP
rs986713229 748 dbSNP
rs1408928843 749 dbSNP
rs776308502 757 dbSNP
rs1308540513 759 dbSNP
rs901956708 760 dbSNP
rs1367102600 761 dbSNP
rs1405144297 764 dbSNP
rs1321542003 765 dbSNP
rs1302097366 770 dbSNP
rs540038828 772 dbSNP
rs761291344 774 dbSNP
rs1385471505 777 dbSNP
rs996335569 779 dbSNP
rs1417402957 780 dbSNP
rs764750012 789 dbSNP
rs1272436439 791 dbSNP
rs752020538 796 dbSNP
rs1478742720 797 dbSNP
rs140330059 798 dbSNP
rs1214121419 800 dbSNP
rs1248929955 803 dbSNP
rs1197430061 805 dbSNP
rs1272549449 809 dbSNP
rs1361919938 811 dbSNP
rs1451382692 812 dbSNP
rs898350963 813 dbSNP
rs931017510 814 dbSNP
rs1054891746 815 dbSNP
rs925941962 817 dbSNP
rs1299741939 818 dbSNP
rs1397935635 818 dbSNP
rs5787989 818 dbSNP
rs894797709 818 dbSNP
rs1449656080 819 dbSNP
rs1359456798 821 dbSNP
rs1006890251 828 dbSNP
rs1016578203 832 dbSNP
rs1013294236 833 dbSNP
rs10665742 833 dbSNP
rs200049258 834 dbSNP
rs1477951148 835 dbSNP
rs1242690204 836 dbSNP
rs1475029611 838 dbSNP
rs1186167614 839 dbSNP
rs1386591569 840 dbSNP
rs1424690727 841 dbSNP
rs1487532732 849 dbSNP
rs1262708835 852 dbSNP
rs1025164657 853 dbSNP
rs902742945 859 dbSNP
rs1444193887 862 dbSNP
rs1276507101 867 dbSNP
rs1024000814 870 dbSNP
rs1280051760 875 dbSNP
rs1216535855 876 dbSNP
rs1162552592 879 dbSNP
rs999749100 880 dbSNP
rs1032431135 881 dbSNP
rs971159671 885 dbSNP
rs368580149 894 dbSNP
rs1449865522 895 dbSNP
rs1357078053 897 dbSNP
rs1332866748 907 dbSNP
rs530626666 910 dbSNP
rs1465711550 913 dbSNP
rs958237372 915 dbSNP
rs551992622 916 dbSNP
rs927128168 917 dbSNP
rs192217246 919 dbSNP
rs975224626 920 dbSNP
rs544523714 921 dbSNP
rs1430609232 925 dbSNP
rs954854413 926 dbSNP
rs1182806808 927 dbSNP
rs1484324645 928 dbSNP
rs755481107 930 dbSNP
rs771956019 933 dbSNP
rs1209455397 938 dbSNP
rs1458302964 939 dbSNP
rs767863818 940 dbSNP
rs7099964 941 dbSNP
rs932054741 942 dbSNP
rs1050580143 944 dbSNP
rs961261746 945 dbSNP
rs1333942119 948 dbSNP
rs879402193 952 dbSNP
rs756565716 953 dbSNP
rs1165865526 957 dbSNP
rs1425956112 959 dbSNP
rs1006414067 965 dbSNP
rs1181546209 968 dbSNP
rs184002338 969 dbSNP
rs1206716746 971 dbSNP
rs919720787 979 dbSNP
rs931199234 980 dbSNP
rs3793883 981 dbSNP
rs1288675642 983 dbSNP
rs916358072 987 dbSNP
rs949044530 988 dbSNP
rs1378469552 989 dbSNP
rs1206777074 1006 dbSNP
rs749566548 1007 dbSNP
rs564568063 1016 dbSNP
rs1034162712 1023 dbSNP
rs186775783 1024 dbSNP
rs1182428362 1036 dbSNP
rs999696614 1037 dbSNP
rs1163170060 1052 dbSNP
rs191579091 1053 dbSNP
rs56386996 1063 dbSNP
rs996382130 1064 dbSNP
rs1418612974 1065 dbSNP
rs779142667 1068 dbSNP
rs976039606 1072 dbSNP
rs1386158714 1074 dbSNP
rs745746380 1075 dbSNP
rs1381169178 1078 dbSNP
rs1400446974 1080 dbSNP
rs1217076731 1081 dbSNP
rs533619082 1081 dbSNP
rs932023553 1087 dbSNP
rs1408928129 1089 dbSNP
rs1238749088 1111 dbSNP
rs954789361 1112 dbSNP
rs1302568997 1114 dbSNP
rs1453559822 1114 dbSNP
rs755174251 1118 dbSNP
rs1336129329 1123 dbSNP
rs1050923878 1126 dbSNP
rs1009004035 1131 dbSNP
rs566370018 1135 dbSNP
rs1401015901 1140 dbSNP
rs3167853 1147 dbSNP
rs1280319944 1149 dbSNP
rs1219584023 1150 dbSNP
rs1349692343 1152 dbSNP
rs1378340664 1159 dbSNP
rs972640359 1160 dbSNP
rs1431307535 1165 dbSNP
rs1428540848 1170 dbSNP
rs1194061706 1178 dbSNP
rs1036573828 1181 dbSNP
rs1489170335 1181 dbSNP
rs898042986 1182 dbSNP
rs1045344477 1189 dbSNP
rs949646901 1189 dbSNP
rs1264991528 1190 dbSNP
rs919895223 1191 dbSNP
rs1230455042 1194 dbSNP
rs952637484 1195 dbSNP
rs78052345 1199 dbSNP
rs143046274 1200 dbSNP
rs1253431923 1202 dbSNP
rs906895382 1204 dbSNP
rs1381935876 1205 dbSNP
rs1182113239 1206 dbSNP
rs916416224 1213 dbSNP
rs1001178493 1217 dbSNP
rs1428473744 1221 dbSNP
rs775568073 1225 dbSNP
rs1478671997 1227 dbSNP
rs1421293643 1228 dbSNP
rs55699322 1233 dbSNP
rs1157397004 1242 dbSNP
rs1423971568 1243 dbSNP
rs1046136971 1245 dbSNP
rs35361397 1247 dbSNP
rs397845504 1247 dbSNP
rs1198190643 1253 dbSNP
rs34227984 1254 dbSNP
rs923597812 1256 dbSNP
rs1470577742 1259 dbSNP
rs1302730176 1265 dbSNP
rs1400198863 1279 dbSNP
rs1276630208 1284 dbSNP
rs935036732 1287 dbSNP
rs1054428094 1296 dbSNP
rs1020116111 1298 dbSNP
rs1394340122 1302 dbSNP
rs748186899 1302 dbSNP
rs551270335 1303 dbSNP
rs1407836507 1304 dbSNP
rs1398041649 1308 dbSNP
rs1167055355 1309 dbSNP
rs1458249174 1325 dbSNP
rs182519552 1327 dbSNP
rs1185027503 1337 dbSNP
rs1443467789 1340 dbSNP
rs1238330487 1341 dbSNP
rs996844189 1344 dbSNP
rs1179979370 1350 dbSNP
rs539052334 1355 dbSNP
rs1222846442 1357 dbSNP
rs1254128414 1359 dbSNP
rs200066265 1360 dbSNP
rs986185044 1363 dbSNP
rs1267440401 1365 dbSNP
rs909288290 1366 dbSNP
rs942130956 1367 dbSNP
rs1449118722 1379 dbSNP
rs1008953013 1382 dbSNP
rs972607545 1383 dbSNP
rs1015051153 1388 dbSNP
rs566222630 1390 dbSNP
rs533676313 1391 dbSNP
rs1405717457 1393 dbSNP
rs11196251 1398 dbSNP
rs150438785 1399 dbSNP
rs1046612639 1401 dbSNP
rs1380546893 1405 dbSNP
rs187178316 1410 dbSNP
rs375337885 1411 dbSNP
rs761349798 1412 dbSNP
rs138209264 1413 dbSNP
rs1370227327 1415 dbSNP
rs1055504987 1420 dbSNP
rs892836255 1421 dbSNP
rs1287048341 1429 dbSNP
rs1428037828 1431 dbSNP
rs970566924 1436 dbSNP
rs1305132471 1437 dbSNP
rs981821106 1438 dbSNP
rs731788 1441 dbSNP
rs1321277194 1445 dbSNP
rs1404136385 1448 dbSNP
rs558418524 1449 dbSNP
rs1404028484 1456 dbSNP
rs934984352 1462 dbSNP
rs1360727109 1468 dbSNP
rs989131340 1470 dbSNP
rs1299183104 1471 dbSNP
rs564505816 1472 dbSNP
rs914908530 1475 dbSNP
rs1020099123 1479 dbSNP
rs761485546 1482 dbSNP
rs1172657544 1483 dbSNP
rs1051128635 1488 dbSNP
rs1227574027 1498 dbSNP
rs1490300261 1499 dbSNP
rs890620144 1501 dbSNP
rs1250248933 1503 dbSNP
rs1339389231 1506 dbSNP
rs1219144991 1515 dbSNP
rs534331614 1518 dbSNP
rs1283570701 1523 dbSNP
rs1219903273 1524 dbSNP
rs1346981106 1532 dbSNP
rs1281339761 1536 dbSNP
rs192852951 1545 dbSNP
rs1036431735 1546 dbSNP
rs1340955336 1552 dbSNP
rs149548874 1558 dbSNP
rs1224293846 1560 dbSNP
rs1279692459 1564 dbSNP
rs997381221 1574 dbSNP
rs1291968266 1576 dbSNP
rs1490619602 1583 dbSNP
rs897943412 1590 dbSNP
rs1190963866 1601 dbSNP
rs1030247617 1606 dbSNP
rs1415714335 1609 dbSNP
rs1265961556 1615 dbSNP
rs1404941481 1622 dbSNP
rs1430779515 1625 dbSNP
rs764660338 1630 dbSNP
rs137902798 1635 dbSNP
rs185357908 1636 dbSNP
rs1424874815 1638 dbSNP
rs894473319 1655 dbSNP
rs1427853959 1656 dbSNP
rs1210862373 1657 dbSNP
rs1444242342 1670 dbSNP
rs772721613 1671 dbSNP
rs1203029684 1672 dbSNP
rs190131632 1675 dbSNP
rs963764746 1677 dbSNP
rs550944612 1679 dbSNP
rs972193812 1684 dbSNP
rs563196035 1687 dbSNP
rs1360789222 1688 dbSNP
rs867599050 1690 dbSNP
rs762580937 1693 dbSNP
rs949541154 1695 dbSNP
rs1030803725 1696 dbSNP
rs1469681293 1705 dbSNP
rs1401683377 1710 dbSNP
rs926874705 1719 dbSNP
rs982280049 1719 dbSNP
rs1419041578 1726 dbSNP
rs527480276 1728 dbSNP
rs989638264 1735 dbSNP
rs914254553 1736 dbSNP
rs1259878893 1745 dbSNP
rs947099819 1746 dbSNP
rs1382734245 1747 dbSNP
rs552642564 1752 dbSNP
rs931674416 1758 dbSNP
rs1041477068 1761 dbSNP
rs902971018 1782 dbSNP
rs1313810288 1784 dbSNP
rs986397550 1785 dbSNP
rs912173620 1786 dbSNP
rs944846024 1787 dbSNP
rs566161296 1790 dbSNP
rs533614938 1791 dbSNP
rs1358280582 1799 dbSNP
rs1378338262 1806 dbSNP
rs149574944 1815 dbSNP
rs1440489446 1816 dbSNP
rs149044108 1823 dbSNP
rs753284898 1824 dbSNP
rs756409004 1826 dbSNP
rs1016655797 1830 dbSNP
rs1163052917 1844 dbSNP
rs894471222 1845 dbSNP
rs1206271968 1848 dbSNP
rs1247873351 1852 dbSNP
rs1013354423 1853 dbSNP
rs373786915 1854 dbSNP
rs1480189207 1855 dbSNP
rs143071937 1856 dbSNP
rs1386142182 1860 dbSNP
rs1356887529 1867 dbSNP
rs1290540176 1871 dbSNP
rs993933133 1875 dbSNP
rs1162889794 1884 dbSNP
rs1355159762 1885 dbSNP
rs184873075 1889 dbSNP
rs1222633759 1892 dbSNP
rs906430446 1896 dbSNP
rs79963628 1906 dbSNP
rs1407116711 1907 dbSNP
rs1363982017 1911 dbSNP
rs764571139 1912 dbSNP
rs1030751406 1921 dbSNP
rs3635 1930 dbSNP
rs926799199 1954 dbSNP
rs1454178655 1966 dbSNP
rs1425755229 1972 dbSNP
rs577987291 1979 dbSNP
rs1010647377 1985 dbSNP
rs1489777140 1986 dbSNP
rs1336780229 1987 dbSNP
rs1267756194 1989 dbSNP
rs1022504386 1990 dbSNP
rs555449578 1992 dbSNP
rs989765170 1993 dbSNP
rs986232644 2002 dbSNP
rs1214436335 2005 dbSNP
rs915501183 2006 dbSNP
rs911575460 2010 dbSNP
rs1308640475 2011 dbSNP
rs1225761005 2013 dbSNP
rs1343962474 2029 dbSNP
rs779340755 2031 dbSNP
rs1400910346 2035 dbSNP
rs3208480 2040 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000354452.3 | 3UTR | AGAAAAAAAGGGAAUGUGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4753-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064916 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT161166 SLC25A36 solute carrier family 25 member 36 2 2
MIRT285542 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT308266 LRIG1 leucine rich repeats and immunoglobulin like domains 1 2 2
MIRT311425 LMNB1 lamin B1 2 2
MIRT373989 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT383141 CRY2 cryptochrome circadian clock 2 2 2
MIRT405243 ADIPOR2 adiponectin receptor 2 2 2
MIRT441620 ROCK1 Rho associated coiled-coil containing protein kinase 1 2 6
MIRT441789 SRPK1 SRSF protein kinase 1 2 2
MIRT441804 NOC3L NOC3 like DNA replication regulator 2 2
MIRT441832 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442005 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT442411 LIMD1 LIM domains containing 1 2 2
MIRT442708 UBE4B ubiquitination factor E4B 2 2
MIRT442714 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT442738 SERINC5 serine incorporator 5 2 2
MIRT442793 CEP170 centrosomal protein 170 2 2
MIRT442984 ZNF736 zinc finger protein 736 2 2
MIRT443055 THRB thyroid hormone receptor beta 2 2
MIRT443288 ZC3H12A zinc finger CCCH-type containing 12A 2 2
MIRT443325 SLC35G1 solute carrier family 35 member G1 2 2
MIRT443331 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT443593 ZNF439 zinc finger protein 439 2 4
MIRT443696 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT443748 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT443866 HDLBP high density lipoprotein binding protein 2 2
MIRT461185 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT464074 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT468738 SDC4 syndecan 4 2 2
MIRT470540 COASY Coenzyme A synthase 2 2
MIRT476458 GBA2 glucosylceramidase beta 2 2 2
MIRT479470 CDK6 cyclin dependent kinase 6 2 2
MIRT486351 TACC2 transforming acidic coiled-coil containing protein 2 2 8
MIRT495126 CXorf67 chromosome X open reading frame 67 2 2
MIRT495166 CNGA2 cyclic nucleotide gated channel alpha 2 2 4
MIRT495432 ATG7 autophagy related 7 2 2
MIRT495922 FBXO41 F-box protein 41 2 2
MIRT496572 DGCR6L DiGeorge syndrome critical region gene 6 like 2 2
MIRT498277 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT498431 DDX39A DExD-box helicase 39A 2 2
MIRT530149 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530313 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT530880 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT531177 ZNF626 zinc finger protein 626 2 2
MIRT533395 TYRP1 tyrosinase related protein 1 2 2
MIRT533709 TMEM64 transmembrane protein 64 2 2
MIRT533954 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT535616 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT539472 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT542878 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT559077 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT559465 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT561233 ZNF772 zinc finger protein 772 2 2
MIRT563477 POLE3 DNA polymerase epsilon 3, accessory subunit 2 2
MIRT563995 SLFN11 schlafen family member 11 2 2
MIRT564222 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT566017 RHOA ras homolog family member A 2 2
MIRT566028 RFX1 regulatory factor X1 2 2
MIRT566591 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT567874 CTDSP1 CTD small phosphatase 1 2 2
MIRT568552 AKT2 AKT serine/threonine kinase 2 2 2
MIRT569357 EFHC1 EF-hand domain containing 1 2 2
MIRT569973 DNAAF2 dynein axonemal assembly factor 2 2 2
MIRT614423 ZNF440 zinc finger protein 440 2 2
MIRT628831 SLC25A34 solute carrier family 25 member 34 2 2
MIRT630142 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT634479 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT634498 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT637394 R3HDM2 R3H domain containing 2 2 2
MIRT641840 TCF7L2 transcription factor 7 like 2 2 2
MIRT644397 CDKL1 cyclin dependent kinase like 1 2 2
MIRT644888 C2orf50 chromosome 2 open reading frame 50 2 2
MIRT647124 ZNF446 zinc finger protein 446 2 2
MIRT647420 SSTR3 somatostatin receptor 3 2 2
MIRT650297 PYCARD PYD and CARD domain containing 2 2
MIRT655488 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT658185 FBXO9 F-box protein 9 2 2
MIRT660931 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT665317 ZBTB3 zinc finger and BTB domain containing 3 2 2
MIRT670350 C1orf106 chromosome 1 open reading frame 106 2 4
MIRT670823 NICN1 nicolin 1 2 2
MIRT671825 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT672732 NETO2 neuropilin and tolloid like 2 2 2
MIRT674841 GLRX2 glutaredoxin 2 2 2
MIRT675930 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT686786 AZF1 azoospermia factor 1 2 2
MIRT697723 USP8 ubiquitin specific peptidase 8 2 2
MIRT702357 KLHL26 kelch like family member 26 2 2
MIRT704361 DBR1 debranching RNA lariats 1 2 2
MIRT709242 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT714433 SNED1 sushi, nidogen and EGF like domains 1 2 2
MIRT717000 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT720875 ADCY5 adenylate cyclase 5 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4753 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4753-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4753-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4753-5p Platinum 23939 resistant tissue
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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