pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CHORDC1   
Synonyms CHP1
Description cysteine and histidine rich domain containing 1
Transcript NM_001144073   
Other Transcripts NM_012124   
Expression
Putative miRNA Targets on CHORDC1
3'UTR of CHORDC1
(miRNA target sites are highlighted)
>CHORDC1|NM_001144073|3'UTR
   1 GTGGGAGATGGAAGGAAGGCTATTACATTATTTCCGAATTTTTAATACTGTGTGAAGTGGTGGCTTGCTGCTGTAATCTT
  81 TTGTTTTGTTGTTGTGTTACTGAATGTGGCATTTCAGGGTTAACATTAGGTTCTTAAAAGCCAAAGTCAGTTTGTCTTTT
 161 TGTGCCTCTCATCTTTCTTTTGTGTTATGTAAGATTGATTATTCATTTCTCCCTACTGGTAGGAACCATAGTTGTGTCCT
 241 ATACTTGAAGAGGCTGGAAAGTAGCCCATAACCATAATTGCAGTATTTCTTTGTATTTCTCTGTTAAGCAAAGAAATATT
 321 AAGGAACATTTTTTTTATGTTTTTGTATTATTCCATAATTAGTAAAGCAAGATGAAATGTCAAATTTTAATCAGTTTTTT
 401 CATGGATTTGTGTTCTTACAGTACTTGAAAATATTTAAGGAAGAGATGAAGCTCTGCAGTTTTTTCTATGTGGGATGATT
 481 ACTTTTTTAAGGAGGATTAATTCTGAGGTAGTATAGTAACTAAAGGGGAATATATGAATTGTTTAACAAATTAGAATTTG
 561 TTTACAACTACTTGAATTTTTAAATTATGTCAAAACTTACATTACTTGCCAAGCAGTATGATGTTATAGGAAACATAAAT
 641 AAGATTACAGAGGTATCAATTTGGTTAAAATTCACCATTTTATAAGACTAAGCAATAATCTTAACAACCTCTTTCCTGAA
 721 TATTTAAATGTGTTTGTATGGTGTTATGACTAATTGTTACTGATTTAGAGACTAAGCCCTCTTAAAACCTTTAGTTAAAT
 801 ATAAAAAGAAATTATATATATCTTGCCTCCCTGATGGAAAACTATATAAAATTGTAGACTTAAAAGGTTTGTGGAAATAC
 881 ATTAGGATATCAGAAAACTAAATATATGGAGTTGCTTTATGACTATTACATGTTAAATAAAAATAGCTTAATTGTTTTGG
 961 AGTTTTTTTTTAAAGTCATGAAGAGCTTCACAATTCTAGTGATACAATGTTGACTATATATTGTACTTTATATTAAATAT
1041 AGGTAATACAGAATTAGATCGTTTGGATAGGTTTTGAGTTAGTGCAGAACTCAAGAAGAAAAATTAGGAAATATTCTGAA
1121 GGCCAGAACTCTGGAAGAACTTAGAAAGTTTGGGAATAAATTAAACTTATGTAGATTTAAAATTAAAAGGGGTTTATTTC
1201 CCAAACCCCTTGAGTCTTTTCTTTTCCTTGGTATTTATGGAATTCTTACAAAGAAAAATTTGCAGAAGTACTATTTTCGT
1281 GAATAAAACATATGTATCATTCTACTACCATTAGCAAATAACTTAGTTGTAGTTAATATAATTGTTAAAAGGTTTAGCTC
1361 TGTTACAAATAAAAACATAAAGATCTGGCAACCAGACTTTCATGATGTTACATTACCATGACAAGAAACTCTGGGCAGTA
1441 AAAGTTGGACCCACATGGAGTACATAAGCATCTGATACCTGGAGATGTATTTAAAATTTTTCAAGTTATCTTCCATGATT
1521 TAGGAACCATTTAGAGACATGAAGTCTTTATGGGTTGGGGGAAAGGTTGATAATTAGTTTGATTAAAGGTAATGATTAAT
1601 ATCCCTTTTTGTTCATACTTCCTTCTGAGGCTGTTTTCCCCTAAACAGTATCTTAATCTGTTACATGTAATTGAAATATT
1681 ATTTGAAGCAGTGAGTTATTGTAACCTCAGATTAGTTACATTGATCAAAACATTGATTTATACACACACACACACACATA
1761 CATATGTAGCTTTTATATTTAGTCTGGTTACATTAGTGACCATGGTATTTACTTTCTTCTTAAGGAGCCTTTGAATTTCT
1841 TGTCCAGATAAAAATCCGAATATTTCTCTTAGACTCATACATAAAGGGACACAGTTATCGTTAGGTAGCATATGTTTTAC
1921 TATCGGTTTGTCAAAAAAGTTAATAAAAAGTGCTTATTGATTTATTTCTCTAGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' gaucggaggUACUUAAGACUac 5'
                   || ||||||||  
Target 5' ttaaggaggATTAATTCTGAgg 3'
487 - 508 137.00 -6.70
2
miRNA  3' gaucggaGGUACU---UAAGACUac 5'
                 ::| ||   |||||||  
Target 5' agaaaaaTTAGGAAATATTCTGAag 3'
1097 - 1121 127.00 -5.90
3
miRNA  3' gaucGGAGGUACUUAAGACUac 5'
              |:|||     ||||||  
Target 5' cataCTTCC-----TTCTGAgg 3'
1614 - 1630 125.00 -10.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30524332 18 COSMIC
COSN30504360 21 COSMIC
COSN26970678 24 COSMIC
COSN30170543 35 COSMIC
COSN13357050 36 COSMIC
COSN30182520 50 COSMIC
COSN31586974 57 COSMIC
COSN30129345 78 COSMIC
COSN31581872 79 COSMIC
COSN30169922 115 COSMIC
COSN7290979 182 COSMIC
COSN24303950 217 COSMIC
COSN31569425 256 COSMIC
COSN32056481 328 COSMIC
COSN26574903 337 COSMIC
COSN21813055 564 COSMIC
COSN26465905 705 COSMIC
COSN1548867 809 COSMIC
COSN25846100 844 COSMIC
COSN20507478 916 COSMIC
COSN31568007 981 COSMIC
COSN32065382 1191 COSMIC
COSN23629316 1235 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs375524609 2 dbSNP
rs1450217245 11 dbSNP
rs1234039753 12 dbSNP
rs778151548 14 dbSNP
rs1311634019 15 dbSNP
rs1447728672 16 dbSNP
rs1346180272 17 dbSNP
rs772495528 18 dbSNP
rs748580673 19 dbSNP
rs369857741 24 dbSNP
rs1165009874 26 dbSNP
rs1298310428 26 dbSNP
rs755561682 27 dbSNP
rs943277755 30 dbSNP
rs911845184 31 dbSNP
rs780821994 34 dbSNP
rs374297329 35 dbSNP
rs1211319143 36 dbSNP
rs986818755 37 dbSNP
rs1243638112 43 dbSNP
rs1218145244 48 dbSNP
rs751156735 49 dbSNP
rs375458529 50 dbSNP
rs1392584549 54 dbSNP
rs1422516929 56 dbSNP
rs1164543033 64 dbSNP
rs1369454116 67 dbSNP
rs549006188 67 dbSNP
rs1459737874 73 dbSNP
rs1318859572 83 dbSNP
rs1292518937 86 dbSNP
rs749394182 89 dbSNP
rs746177244 91 dbSNP
rs1204510950 93 dbSNP
rs1435923200 104 dbSNP
rs955519683 105 dbSNP
rs1367303599 108 dbSNP
rs1226489315 113 dbSNP
rs775748220 115 dbSNP
rs1340217390 123 dbSNP
rs112836856 131 dbSNP
rs1246715945 154 dbSNP
rs1265923270 160 dbSNP
rs528882702 161 dbSNP
rs1446956638 162 dbSNP
rs1277005063 164 dbSNP
rs973200031 166 dbSNP
rs1249289961 170 dbSNP
rs371904791 174 dbSNP
rs1181826697 176 dbSNP
rs769959005 182 dbSNP
rs1393273001 186 dbSNP
rs1323526946 188 dbSNP
rs1367278931 192 dbSNP
rs1157322684 193 dbSNP
rs1411512342 194 dbSNP
rs746752801 210 dbSNP
rs1017097478 213 dbSNP
rs777741702 214 dbSNP
rs1447347441 215 dbSNP
rs368474747 218 dbSNP
rs1302263215 221 dbSNP
rs1379793617 228 dbSNP
rs1012454407 238 dbSNP
rs565430481 241 dbSNP
rs1328089576 267 dbSNP
rs566420386 271 dbSNP
rs1228677319 289 dbSNP
rs1035231011 305 dbSNP
rs1309994983 307 dbSNP
rs758346804 319 dbSNP
rs185568478 328 dbSNP
rs1042072745 329 dbSNP
rs1484486691 329 dbSNP
rs533029640 336 dbSNP
rs1011053050 337 dbSNP
rs1184663789 337 dbSNP
rs1459206224 337 dbSNP
rs1371911570 339 dbSNP
rs1176814287 344 dbSNP
rs1359681447 345 dbSNP
rs1436464680 345 dbSNP
rs1305983325 353 dbSNP
rs1349688884 357 dbSNP
rs1168815229 360 dbSNP
rs1280984338 364 dbSNP
rs1364979036 373 dbSNP
rs893584826 392 dbSNP
rs943246384 410 dbSNP
rs1203697909 413 dbSNP
rs564695569 415 dbSNP
rs193302183 417 dbSNP
rs911729030 423 dbSNP
rs532984137 435 dbSNP
rs1184768760 443 dbSNP
rs531272197 453 dbSNP
rs929254684 455 dbSNP
rs918561927 461 dbSNP
rs562241762 466 dbSNP
rs1250985449 468 dbSNP
rs189439328 469 dbSNP
rs1369856497 470 dbSNP
rs1482104411 470 dbSNP
rs962775443 488 dbSNP
rs1430177877 489 dbSNP
rs1254104529 493 dbSNP
rs573166301 494 dbSNP
rs1435245243 499 dbSNP
rs1311828755 503 dbSNP
rs1276873381 509 dbSNP
rs1221279872 515 dbSNP
rs1275052023 518 dbSNP
rs1225540738 528 dbSNP
rs1372592019 528 dbSNP
rs1324798331 548 dbSNP
rs1288235729 550 dbSNP
rs1297588047 552 dbSNP
rs1343426954 556 dbSNP
rs1408588205 560 dbSNP
rs1197936219 567 dbSNP
rs1158203130 574 dbSNP
rs1288125370 578 dbSNP
rs1451277169 580 dbSNP
rs1222653427 584 dbSNP
rs1248665378 591 dbSNP
rs1351746740 596 dbSNP
rs1389484700 600 dbSNP
rs559667363 600 dbSNP
rs1169447641 604 dbSNP
rs1411416739 606 dbSNP
rs959491448 610 dbSNP
rs1035207775 613 dbSNP
rs545916313 616 dbSNP
rs778777609 624 dbSNP
rs1004179667 626 dbSNP
rs770836651 627 dbSNP
rs754509293 629 dbSNP
rs1282924207 640 dbSNP
rs1356167458 643 dbSNP
rs550288912 643 dbSNP
rs1414797372 645 dbSNP
rs1411027480 646 dbSNP
rs1275293611 650 dbSNP
rs1208220444 659 dbSNP
rs34769715 663 dbSNP
rs1156804110 675 dbSNP
rs967009430 676 dbSNP
rs184672857 681 dbSNP
rs1010606453 688 dbSNP
rs1177864655 701 dbSNP
rs753333473 707 dbSNP
rs1235940496 709 dbSNP
rs557569208 711 dbSNP
rs1419580301 720 dbSNP
rs1455283703 727 dbSNP
rs1017269400 730 dbSNP
rs1388800116 735 dbSNP
rs1383386843 737 dbSNP
rs1212558825 747 dbSNP
rs1340328484 750 dbSNP
rs1462028603 754 dbSNP
rs1295456597 755 dbSNP
rs537643989 766 dbSNP
rs1267918647 780 dbSNP
rs1327366951 788 dbSNP
rs1228068015 789 dbSNP
rs1268969074 790 dbSNP
rs1353018470 801 dbSNP
rs1198790686 808 dbSNP
rs1276435027 812 dbSNP
rs1188433354 815 dbSNP
rs1259298491 817 dbSNP
rs1227025096 820 dbSNP
rs1007272092 825 dbSNP
rs1331857381 827 dbSNP
rs1454902808 837 dbSNP
rs890261222 846 dbSNP
rs1051625280 849 dbSNP
rs192079718 865 dbSNP
rs1349061837 877 dbSNP
rs1409595050 877 dbSNP
rs1289284056 887 dbSNP
rs1337697749 892 dbSNP
rs1376393417 894 dbSNP
rs897772572 898 dbSNP
rs187225159 905 dbSNP
rs1452948732 911 dbSNP
rs941300235 913 dbSNP
rs535705113 916 dbSNP
rs1387591132 919 dbSNP
rs1318295938 922 dbSNP
rs1458692215 925 dbSNP
rs1345698923 930 dbSNP
rs1164076494 932 dbSNP
rs183098985 940 dbSNP
rs1376622775 942 dbSNP
rs1411780687 942 dbSNP
rs990871669 943 dbSNP
rs1176152909 944 dbSNP
rs1445502805 962 dbSNP
rs546597041 963 dbSNP
rs539574048 970 dbSNP
rs938094871 971 dbSNP
rs1300824146 972 dbSNP
rs1331798280 972 dbSNP
rs1385260464 972 dbSNP
rs1236585557 975 dbSNP
rs1247733641 975 dbSNP
rs928102941 978 dbSNP
rs1339890103 979 dbSNP
rs982330503 988 dbSNP
rs1251621532 992 dbSNP
rs1481479493 993 dbSNP
rs1466582294 1001 dbSNP
rs1261796534 1012 dbSNP
rs967355494 1016 dbSNP
rs1021247913 1022 dbSNP
rs570552796 1022 dbSNP
rs773261026 1039 dbSNP
rs1319356354 1043 dbSNP
rs3834437 1049 dbSNP
rs397840939 1049 dbSNP
rs1246166879 1051 dbSNP
rs371199562 1061 dbSNP
rs1295017427 1064 dbSNP
rs192320274 1091 dbSNP
rs1456687830 1092 dbSNP
rs1293229430 1104 dbSNP
rs1391712273 1104 dbSNP
rs1362445018 1140 dbSNP
rs1318572189 1143 dbSNP
rs1292846533 1145 dbSNP
rs1434340072 1150 dbSNP
rs767879241 1157 dbSNP
rs1007242789 1158 dbSNP
rs762220011 1159 dbSNP
rs1242321416 1160 dbSNP
rs1030568612 1170 dbSNP
rs1215056864 1170 dbSNP
rs752101425 1176 dbSNP
rs551242768 1177 dbSNP
rs1464034368 1184 dbSNP
rs561512283 1198 dbSNP
rs1389779628 1208 dbSNP
rs1264479539 1210 dbSNP
rs1422500256 1219 dbSNP
rs1186955696 1237 dbSNP
rs1164434765 1247 dbSNP
rs1418882977 1249 dbSNP
rs1463163582 1250 dbSNP
rs993380758 1254 dbSNP
rs1430643496 1259 dbSNP
rs1431564194 1263 dbSNP
rs1289433437 1266 dbSNP
rs188042057 1273 dbSNP
rs1191087467 1278 dbSNP
rs540049400 1279 dbSNP
rs1266631089 1283 dbSNP
rs1037588288 1288 dbSNP
rs1234803966 1290 dbSNP
rs1327952481 1292 dbSNP
rs1215871878 1293 dbSNP
rs1263035444 1294 dbSNP
rs1340932497 1294 dbSNP
rs1482537316 1295 dbSNP
rs1181659230 1319 dbSNP
rs1258712036 1322 dbSNP
rs1476371761 1342 dbSNP
rs1180372639 1343 dbSNP
rs562269092 1345 dbSNP
rs1401371506 1350 dbSNP
rs1230226094 1380 dbSNP
rs1346927372 1382 dbSNP
rs1464441121 1390 dbSNP
rs10741326 1391 dbSNP
rs1416389467 1392 dbSNP
rs1055153656 1396 dbSNP
rs770101539 1397 dbSNP
rs1308452164 1400 dbSNP
rs1309908959 1401 dbSNP
rs528756528 1412 dbSNP
rs1281660122 1420 dbSNP
rs1486890808 1421 dbSNP
rs1203383016 1424 dbSNP
rs1251365006 1426 dbSNP
rs1179050426 1428 dbSNP
rs982686104 1428 dbSNP
rs559517464 1430 dbSNP
rs1423214907 1432 dbSNP
rs1432639355 1445 dbSNP
rs879390858 1451 dbSNP
rs1370081467 1454 dbSNP
rs781526191 1464 dbSNP
rs61903698 1469 dbSNP
rs1166891547 1472 dbSNP
rs1305886251 1474 dbSNP
rs914064444 1477 dbSNP
rs989662964 1479 dbSNP
rs80082534 1481 dbSNP
rs576967814 1482 dbSNP
rs747031066 1487 dbSNP
rs1232908627 1492 dbSNP
rs563441023 1509 dbSNP
rs985790580 1515 dbSNP
rs543468671 1528 dbSNP
rs1271681859 1529 dbSNP
rs1274308391 1531 dbSNP
rs1438731023 1534 dbSNP
rs954605418 1549 dbSNP
rs575362401 1554 dbSNP
rs1249013628 1562 dbSNP
rs1488232278 1563 dbSNP
rs1194280780 1566 dbSNP
rs1395621353 1570 dbSNP
rs1455492972 1581 dbSNP
rs1166612045 1588 dbSNP
rs993659149 1594 dbSNP
rs116906195 1600 dbSNP
rs1172158214 1601 dbSNP
rs1347694020 1602 dbSNP
rs1439526272 1604 dbSNP
rs1255112391 1611 dbSNP
rs1230787576 1614 dbSNP
rs1313777854 1615 dbSNP
rs1283821616 1617 dbSNP
rs1227728876 1618 dbSNP
rs1325946132 1620 dbSNP
rs771981971 1622 dbSNP
rs1433589949 1633 dbSNP
rs1270096316 1639 dbSNP
rs1340586995 1648 dbSNP
rs1016121174 1650 dbSNP
rs1006124442 1651 dbSNP
rs1334361346 1661 dbSNP
rs4753261 1663 dbSNP
rs1255011044 1671 dbSNP
rs573075296 1681 dbSNP
rs1186664887 1683 dbSNP
rs182535804 1693 dbSNP
rs1475625710 1696 dbSNP
rs149177479 1699 dbSNP
rs1192005328 1706 dbSNP
rs1464833966 1709 dbSNP
rs1165169853 1711 dbSNP
rs570414680 1713 dbSNP
rs1396085710 1719 dbSNP
rs1431967234 1720 dbSNP
rs1318313829 1721 dbSNP
rs945466821 1728 dbSNP
rs1433335363 1733 dbSNP
rs1282750606 1740 dbSNP
rs1355195299 1741 dbSNP
rs1234171696 1744 dbSNP
rs151282456 1749 dbSNP
rs191022336 1751 dbSNP
rs1177723739 1754 dbSNP
rs71472293 1758 dbSNP
rs1204569958 1759 dbSNP
rs1327231194 1759 dbSNP
rs1447470496 1759 dbSNP
rs1491444783 1759 dbSNP
rs34095734 1759 dbSNP
rs398045391 1759 dbSNP
rs750012825 1759 dbSNP
rs1188300051 1761 dbSNP
rs750879258 1762 dbSNP
rs1053906480 1763 dbSNP
rs1409044396 1763 dbSNP
rs1183373285 1765 dbSNP
rs1437973568 1766 dbSNP
rs1255009270 1767 dbSNP
rs936913313 1782 dbSNP
rs910841211 1787 dbSNP
rs778882421 1792 dbSNP
rs954367995 1793 dbSNP
rs1415781546 1794 dbSNP
rs1295355724 1797 dbSNP
rs1207955765 1802 dbSNP
rs1327008914 1805 dbSNP
rs1280170882 1807 dbSNP
rs1352892907 1813 dbSNP
rs370728461 1815 dbSNP
rs1278083564 1816 dbSNP
rs922941003 1823 dbSNP
rs550705028 1825 dbSNP
rs971814201 1828 dbSNP
rs370305180 1834 dbSNP
rs1312254427 1841 dbSNP
rs1016091670 1848 dbSNP
rs142982606 1855 dbSNP
rs1394938188 1857 dbSNP
rs537115335 1858 dbSNP
rs1457123438 1862 dbSNP
rs1034230076 1876 dbSNP
rs1391080376 1886 dbSNP
rs1329764827 1896 dbSNP
rs1387085979 1897 dbSNP
rs1003211964 1898 dbSNP
rs906506066 1899 dbSNP
rs1301162635 1900 dbSNP
rs1346985998 1906 dbSNP
rs1367404899 1909 dbSNP
rs11018908 1910 dbSNP
rs1479515609 1912 dbSNP
rs1446083209 1922 dbSNP
rs1009638232 1924 dbSNP
rs1439050634 1925 dbSNP
rs1207859228 1926 dbSNP
rs1191147253 1927 dbSNP
rs1252947411 1939 dbSNP
rs1455055050 1939 dbSNP
rs1176044000 1951 dbSNP
rs548743830 1953 dbSNP
rs115562269 1955 dbSNP
rs1168778610 1959 dbSNP
rs1398820874 1963 dbSNP
rs11018907 1964 dbSNP
rs200140763 1964 dbSNP
rs936882382 1970 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000334660.5 | 3UTR | AAAAGGGAAGAAUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000334660.5 | 3UTR | AAAAGGGAAGAAUGUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.543 0.02 0.675 0 14 Click to see details
STAD 0.955 0.1 1.000 0.5 3 Click to see details
BLCA -0.536 0.14 -0.257 0.31 6 Click to see details
LIHC 0.675 0.16 0.400 0.3 4 Click to see details
BRCA 0.113 0.27 0.040 0.42 31 Click to see details
UCEC -0.585 0.3 -0.500 0.33 3 Click to see details
LUSC -0.021 0.47 0.057 0.42 15 Click to see details
LUSC -0.021 0.47 0.057 0.42 15 Click to see details
LUSC -0.021 0.47 0.057 0.42 15 Click to see details
LUSC -0.021 0.47 0.057 0.42 15 Click to see details
LUSC -0.021 0.47 0.057 0.42 15 Click to see details
LUSC -0.021 0.47 0.057 0.42 15 Click to see details
LUSC -0.021 0.47 0.057 0.42 15 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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