pre-miRNA Information
pre-miRNA hsa-mir-452   
Genomic Coordinates chrX: 151959628 - 151959712
Synonyms MIRN452, hsa-mir-452, MIR452
Description Homo sapiens miR-452 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-452-3p
Sequence 58| CUCAUCUGCAAAGAAGUAAGUG |79
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 X - 151959644 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757928550 3 dbSNP
rs1324216965 6 dbSNP
rs1390793899 13 dbSNP
rs899383242 17 dbSNP
rs747858567 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol EPPIN   
Synonyms CT71, CT72, SPINLW1, WAP7, WFDC7, dJ461P17.2
Description epididymal peptidase inhibitor
Transcript NM_020398   
Expression
Putative miRNA Targets on EPPIN
3'UTR of EPPIN
(miRNA target sites are highlighted)
>EPPIN|NM_020398|3'UTR
   1 TTGGATAAGGATGCACTGGAAGAACTGCCAGAATGTGGCTCATGCTCTGAGTACTGTTCCTGTACCTGACGGATGCTCCA
  81 GACTGGCTTCCAGTTTCACTCTCAGCATTCCAAGATCTTAGCCCTTCCCAGAACAGAACGCTTGCATCTACCTCCTCTTC
 161 CTCCATCTTTGGCTCTTTTGATGCACAATATCCATCCGTTTTGATTTCATCTTTATGTCCCCTTTATCTCCAACTTCTAG
 241 AACTCCCAGTTTATACCTGTGTCACTCTCAATTTTTTCCAGTAAAGTACTTGATGTAGTCCTGTGCCTTGAGGCTGAGTG
 321 ATTGACATCTTTTTGGCACATTACACTTTGCAGAGTAAGGGATCATTGAGGCTTCTGGTGACATCATTCAAGGGAGTGAA
 401 GACAATCAGAACTTTGAGAGTTCAGAGTTCCAGGAATATTGTTATTGTTATCTTCCTCTGTTTCTACAAAAGATTGTAAA
 481 ACCCTTTTTAGGCAAGGGCCCAAGGACAGTGCCTTAGTTTGGATCCTCTAGAAACTAACCCTGGGAAAAGGGCATGGGTG
 561 CAGGTAGTTTGTTTGAGAGATTTCCCAGGACATACAAGATGGGGAGTGAGATGAGTAATTCAGGGAAGAGAAGGGAAGAG
 641 AGAAGAGTCTATTATGAGCTGGTTACTACTGTGGCTCAATCCTATTGGGGACCTTTTAAAGAATCATGTAAAACAGGCTT
 721 ACAAATTTTCTTTTTAAAAATATTTTATTTTATTTTACGTTCCGGGATACATGTGCAGGACCTGCAGGTTTGTTACATAG
 801 GTAAGCCTGTGCCATGGTGGTTTGCTGCACCTATCAACCCATTACCTGGGTATTAAGCCCCGCATGCATTAGCTATTTAT
 881 CCTGATGCTTTCCCTCCCCCTGCCCCCTCAACAGTCCACGTGTTCTCATTGTTCATCTCCCACTTGCAAGTGAGAACATG
 961 TGGTATTTACTTTTGTTCCTGCGTTACTTTGCTGAGGATAACGGCTTCCAGCTTCATCCATGTCCCTGCAAAGGACGTGA
1041 TCTCATTTCTTTTTATGGCTGCATAGTATTCCATGGCATATATGTACCACATTTTCTTTATCCAGCCTATCGTTGATGGA
1121 TATTTGGTTTGATTCCATGTTTTTGCTATTGTAAATAGTGCTGCAGTGAACATACACATGCATGTATCTTTATAAAAGAA
1201 TGATTTATATTCCTTTGAGTGTATACCCAGTAATGGGATTGCTGGGTCAAATGGTATTTCTGGTTCTAGATCTTTCAGGA
1281 ATTGGCACACTCTCTTCCACAATGGTTGAACCAATTTACATTCCCAACAGTGTAAAAGCATTCATGTTTCTCCACAGCTT
1361 TACCAGCATCTGTTGTTTCTGGACTTTTTAATAATCACCATTCTGACTGGCATGAGATGGTATCTCATTGTGGTTTTGAT
1441 TTGCATTTCTCTGATGATCACTGGTGTTGAGCTTTTTTTCATATGTTTGTTGGCCGCATAAATGTCTTCTTTTGAGAAAA
1521 AAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' guGAAUGAAGAAACGUCUACUc 5'
            :||:| |:| | | ||||| 
Target 5' gaTTTGCATTTCT-CTGATGAt 3'
1438 - 1458 127.00 -6.90
2
miRNA  3' gugaaugaagaaacgUCUACUc 5'
                         |||||| 
Target 5' acaagatggggagtgAGATGAg 3'
594 - 615 120.00 -10.15
3
miRNA  3' gugaaUGAAGAAACGUCUACuc 5'
               :|||:||| || |||  
Target 5' gttgaGCTTTTTTTCATATGtt 3'
1466 - 1487 117.00 -7.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30447906 3 COSMIC
COSN30476675 10 COSMIC
COSN20086010 22 COSMIC
COSN30478108 60 COSMIC
COSN31599968 76 COSMIC
COSN30472936 97 COSMIC
COSN31537088 141 COSMIC
COSN30146416 154 COSMIC
COSN31601418 164 COSMIC
COSN2525749 166 COSMIC
COSN24906387 209 COSMIC
COSN17183055 237 COSMIC
COSN28282811 298 COSMIC
COSN32064536 409 COSMIC
COSN21980331 445 COSMIC
COSN22350154 521 COSMIC
COSN18940365 756 COSMIC
COSN16031174 771 COSMIC
COSN1873652 844 COSMIC
COSN31959822 1127 COSMIC
COSN6560602 1229 COSMIC
COSN26121179 1251 COSMIC
COSN20672120 1311 COSMIC
COSN9130191 1489 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752179668 1 dbSNP
rs766974861 4 dbSNP
rs1281563216 6 dbSNP
rs1204113541 14 dbSNP
rs535473089 16 dbSNP
rs751229092 17 dbSNP
rs765580262 19 dbSNP
rs562681520 27 dbSNP
rs369195525 34 dbSNP
rs764722304 36 dbSNP
rs1291063706 38 dbSNP
rs1360576477 48 dbSNP
rs188765946 62 dbSNP
rs6032282 66 dbSNP
rs11594 71 dbSNP
rs553164406 72 dbSNP
rs1243999189 74 dbSNP
rs1000113555 75 dbSNP
rs745955745 76 dbSNP
rs1447339147 89 dbSNP
rs904466049 101 dbSNP
rs1240280021 102 dbSNP
rs1352003553 106 dbSNP
rs779324137 110 dbSNP
rs1184146137 112 dbSNP
rs1241910945 123 dbSNP
rs1378050433 125 dbSNP
rs371061047 127 dbSNP
rs1007530767 128 dbSNP
rs558361328 139 dbSNP
rs540259288 140 dbSNP
rs967533664 144 dbSNP
rs1401648299 146 dbSNP
rs890472434 149 dbSNP
rs147369513 157 dbSNP
rs929399924 163 dbSNP
rs754292016 166 dbSNP
rs1382059542 174 dbSNP
rs1450599279 175 dbSNP
rs958272060 182 dbSNP
rs1156778782 184 dbSNP
rs897990510 185 dbSNP
rs1281812382 186 dbSNP
rs1325429650 196 dbSNP
rs73910209 198 dbSNP
rs1007795741 208 dbSNP
rs1262485891 221 dbSNP
rs942266555 224 dbSNP
rs1180044595 227 dbSNP
rs1238755896 234 dbSNP
rs535764356 239 dbSNP
rs1175129225 253 dbSNP
rs926904152 256 dbSNP
rs1030307919 261 dbSNP
rs997571661 268 dbSNP
rs1467016538 269 dbSNP
rs1468292058 280 dbSNP
rs897912875 281 dbSNP
rs1331039015 282 dbSNP
rs1336439834 291 dbSNP
rs1278033983 300 dbSNP
rs1441662762 300 dbSNP
rs1347137632 301 dbSNP
rs1223934254 304 dbSNP
rs1036483553 312 dbSNP
rs1262431839 321 dbSNP
rs1321402383 322 dbSNP
rs981441514 339 dbSNP
rs941839898 340 dbSNP
rs1222252667 346 dbSNP
rs1252546679 361 dbSNP
rs1436757615 370 dbSNP
rs887638464 372 dbSNP
rs1270653625 373 dbSNP
rs764470570 382 dbSNP
rs1200682184 387 dbSNP
rs1429182047 392 dbSNP
rs574754366 398 dbSNP
rs1055690426 408 dbSNP
rs1358514564 427 dbSNP
rs992584603 448 dbSNP
rs1397253015 452 dbSNP
rs1409507362 453 dbSNP
rs1259067414 455 dbSNP
rs1327064768 457 dbSNP
rs1367764884 460 dbSNP
rs937258550 468 dbSNP
rs556383784 479 dbSNP
rs1282337802 482 dbSNP
rs756407064 483 dbSNP
rs978620831 484 dbSNP
rs1270724680 489 dbSNP
rs1338151097 500 dbSNP
rs981519869 508 dbSNP
rs968553429 511 dbSNP
rs1293483067 512 dbSNP
rs1232470941 516 dbSNP
rs1490427382 521 dbSNP
rs1221295746 525 dbSNP
rs945763585 539 dbSNP
rs1450271856 550 dbSNP
rs1195893257 555 dbSNP
rs1370717981 559 dbSNP
rs1374188638 560 dbSNP
rs1475123407 563 dbSNP
rs912972996 571 dbSNP
rs1387179258 573 dbSNP
rs866408996 574 dbSNP
rs1302814165 576 dbSNP
rs377717832 581 dbSNP
rs1322420773 596 dbSNP
rs1363435987 606 dbSNP
rs1387015058 610 dbSNP
rs878966466 612 dbSNP
rs1286578152 613 dbSNP
rs958187816 615 dbSNP
rs1224591667 618 dbSNP
rs538044406 628 dbSNP
rs1017498386 633 dbSNP
rs1032486748 634 dbSNP
rs374792773 642 dbSNP
rs1359538572 645 dbSNP
rs1007892748 647 dbSNP
rs890426665 649 dbSNP
rs570956628 655 dbSNP
rs986323533 660 dbSNP
rs1354651486 677 dbSNP
rs867376309 684 dbSNP
rs552367257 685 dbSNP
rs1446872374 687 dbSNP
rs752363565 692 dbSNP
rs183664369 697 dbSNP
rs942173112 698 dbSNP
rs6124714 710 dbSNP
rs866290570 712 dbSNP
rs879593438 714 dbSNP
rs1259966866 715 dbSNP
rs905375237 716 dbSNP
rs1015409411 730 dbSNP
rs1006317891 735 dbSNP
rs1455143855 737 dbSNP
rs1158987509 749 dbSNP
rs192455585 758 dbSNP
rs566628932 759 dbSNP
rs759039781 763 dbSNP
rs548562423 764 dbSNP
rs1001416692 772 dbSNP
rs1337222241 773 dbSNP
rs1239336871 788 dbSNP
rs1261614859 791 dbSNP
rs766278103 797 dbSNP
rs1207335931 799 dbSNP
rs1265599255 800 dbSNP
rs1461804309 801 dbSNP
rs1183135702 809 dbSNP
rs1254316842 822 dbSNP
rs1275788492 830 dbSNP
rs1182802739 847 dbSNP
rs1362967615 851 dbSNP
rs1455464623 853 dbSNP
rs142763330 859 dbSNP
rs1406824143 860 dbSNP
rs6124713 861 dbSNP
rs533215012 862 dbSNP
rs912928827 873 dbSNP
rs143891238 880 dbSNP
rs533208295 883 dbSNP
rs1285742884 888 dbSNP
rs925416151 892 dbSNP
rs373645529 895 dbSNP
rs1203596854 902 dbSNP
rs1401475856 902 dbSNP
rs1172917079 903 dbSNP
rs1478927292 905 dbSNP
rs1371489540 906 dbSNP
rs149637606 915 dbSNP
rs923516420 919 dbSNP
rs1192750862 920 dbSNP
rs1480031698 922 dbSNP
rs1030313945 923 dbSNP
rs1355726089 927 dbSNP
rs993485365 946 dbSNP
rs976389518 959 dbSNP
rs1208882875 964 dbSNP
rs188961971 970 dbSNP
rs560563732 982 dbSNP
rs184082842 983 dbSNP
rs1006263220 985 dbSNP
rs761687234 992 dbSNP
rs1309309035 993 dbSNP
rs1249192700 1000 dbSNP
rs138351567 1002 dbSNP
rs556422609 1003 dbSNP
rs1482164536 1005 dbSNP
rs1034465921 1010 dbSNP
rs538459839 1021 dbSNP
rs1490132308 1024 dbSNP
rs1279521048 1027 dbSNP
rs1013821807 1030 dbSNP
rs193086651 1036 dbSNP
rs1169200522 1037 dbSNP
rs907061658 1045 dbSNP
rs765571515 1050 dbSNP
rs1426087390 1051 dbSNP
rs187227481 1056 dbSNP
rs1052700696 1063 dbSNP
rs1366528344 1066 dbSNP
rs1436266376 1071 dbSNP
rs1046048407 1099 dbSNP
rs934291144 1102 dbSNP
rs1010169958 1103 dbSNP
rs1394101749 1111 dbSNP
rs891434746 1112 dbSNP
rs1042794723 1116 dbSNP
rs1292845073 1117 dbSNP
rs534042725 1122 dbSNP
rs772302486 1138 dbSNP
rs1358428383 1150 dbSNP
rs947158373 1151 dbSNP
rs1243767495 1158 dbSNP
rs566923955 1161 dbSNP
rs548650236 1166 dbSNP
rs1185860246 1173 dbSNP
rs1185890672 1175 dbSNP
rs1245621827 1177 dbSNP
rs1445947091 1179 dbSNP
rs1163801759 1180 dbSNP
rs935718211 1184 dbSNP
rs1405136338 1190 dbSNP
rs910964229 1198 dbSNP
rs1163052157 1202 dbSNP
rs1347323071 1205 dbSNP
rs1049506923 1215 dbSNP
rs1472542048 1218 dbSNP
rs150486053 1219 dbSNP
rs1190229709 1221 dbSNP
rs1436392053 1236 dbSNP
rs1320502817 1239 dbSNP
rs569210858 1242 dbSNP
rs1363094115 1248 dbSNP
rs745980019 1284 dbSNP
rs1315993356 1291 dbSNP
rs976717256 1294 dbSNP
rs1226831991 1296 dbSNP
rs986391996 1298 dbSNP
rs6017604 1311 dbSNP
rs923160746 1343 dbSNP
rs1266213547 1347 dbSNP
rs1318134479 1351 dbSNP
rs971971123 1358 dbSNP
rs1259667518 1361 dbSNP
rs6017603 1363 dbSNP
rs984779615 1373 dbSNP
rs952063971 1383 dbSNP
rs1016225150 1390 dbSNP
rs6032281 1398 dbSNP
rs59190933 1401 dbSNP
rs145043352 1405 dbSNP
rs1330389576 1410 dbSNP
rs560638322 1413 dbSNP
rs1447327366 1414 dbSNP
rs1024162376 1416 dbSNP
rs1402710681 1418 dbSNP
rs1023793825 1419 dbSNP
rs749802336 1423 dbSNP
rs1404773398 1425 dbSNP
rs1337410755 1428 dbSNP
rs1414665139 1429 dbSNP
rs1165457922 1441 dbSNP
rs891719880 1443 dbSNP
rs1446045015 1449 dbSNP
rs542246761 1462 dbSNP
rs999788667 1463 dbSNP
rs1227603000 1471 dbSNP
rs1179650949 1475 dbSNP
rs778197072 1479 dbSNP
rs141315389 1480 dbSNP
rs113693341 1481 dbSNP
rs1211469667 1484 dbSNP
rs1450486517 1485 dbSNP
rs1206154336 1489 dbSNP
rs1289941046 1491 dbSNP
rs1470713001 1494 dbSNP
rs780747813 1494 dbSNP
rs544592695 1495 dbSNP
rs143681828 1496 dbSNP
rs1050194289 1501 dbSNP
rs1177831550 1503 dbSNP
rs1308519653 1506 dbSNP
rs148929549 1517 dbSNP
rs1412890966 1518 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000555685.1 | 3UTR | AAAAGAGAGGAAGAUGAAGCUGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000555685.1 | 3UTR | AAAAGAGAGGAAGAUGAAGCUGGGCUAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-452-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT150000 MIDN midnolin 2 10
MIRT330600 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT358701 SUB1 SUB1 homolog, transcriptional regulator 2 4
MIRT362854 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT447215 ATXN7 ataxin 7 2 2
MIRT466655 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT483979 PANK1 pantothenate kinase 1 2 8
MIRT485118 SF3B3 splicing factor 3b subunit 3 2 2
MIRT488864 AUTS8 Autism, susceptibility to, 8 2 2
MIRT492293 SH2B3 SH2B adaptor protein 3 2 2
MIRT492976 NCK2 NCK adaptor protein 2 2 2
MIRT497410 LRRC40 leucine rich repeat containing 40 2 2
MIRT511143 MRPL17 mitochondrial ribosomal protein L17 2 6
MIRT512650 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT513017 NSFL1C NSFL1 cofactor 2 6
MIRT520445 TSPAN2 tetraspanin 2 2 6
MIRT527995 NDNF neuron derived neurotrophic factor 2 2
MIRT528667 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT533512 TRIM71 tripartite motif containing 71 2 2
MIRT537404 FBXO47 F-box protein 47 2 2
MIRT538161 DCP2 decapping mRNA 2 2 2
MIRT539124 ARHGEF17 Rho guanine nucleotide exchange factor 17 2 2
MIRT540666 MIS18A MIS18 kinetochore protein A 2 4
MIRT542948 GDF11 growth differentiation factor 11 2 2
MIRT547534 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT559033 C20orf24 chromosome 20 open reading frame 24 2 4
MIRT559554 ARF6 ADP ribosylation factor 6 2 2
MIRT570177 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT573149 ITGA9 integrin subunit alpha 9 2 2
MIRT575849 Rab1 RAB1A, member RAS oncogene family 1 1
MIRT611034 RRP1B ribosomal RNA processing 1B 2 2
MIRT616281 HMGB1 high mobility group box 1 2 2
MIRT618372 PRKG2 protein kinase, cGMP-dependent, type II 2 2
MIRT619540 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT622303 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT622590 PRRG4 proline rich and Gla domain 4 2 2
MIRT624441 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT637089 KLRD1 killer cell lectin like receptor D1 2 2
MIRT639084 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT639334 NINJ1 ninjurin 1 2 2
MIRT639798 EIF3E eukaryotic translation initiation factor 3 subunit E 2 2
MIRT640851 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT641628 KIAA1244 ARFGEF family member 3 1 1
MIRT642634 EPPIN epididymal peptidase inhibitor 2 2
MIRT643053 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643416 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT645586 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT647393 FAM181B family with sequence similarity 181 member B 2 2
MIRT649411 CDC14B cell division cycle 14B 2 2
MIRT649477 CLDN16 claudin 16 2 2
MIRT651307 ZDHHC20 zinc finger DHHC-type containing 20 2 2
MIRT651387 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT653411 SLC7A2 solute carrier family 7 member 2 2 2
MIRT654084 RSPH4A radial spoke head 4 homolog A 2 2
MIRT654613 PTPRM protein tyrosine phosphatase, receptor type M 2 2
MIRT655338 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT656173 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT657272 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT657881 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659875 CAPRIN1 cell cycle associated protein 1 2 2
MIRT662381 ICA1L islet cell autoantigen 1 like 2 4
MIRT666308 SLC22A3 solute carrier family 22 member 3 2 2
MIRT667274 NAV1 neuron navigator 1 2 2
MIRT667614 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT674242 NUP62 nucleoporin 62 2 4
MIRT690386 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT693402 NUDT16 nudix hydrolase 16 2 2
MIRT702503 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT708632 STMN4 stathmin 4 2 2
MIRT708839 SCAND3 zinc finger BED-type containing 9 1 1
MIRT709016 HSBP1 heat shock factor binding protein 1 2 2
MIRT709235 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT710885 PARL presenilin associated rhomboid like 2 2
MIRT712262 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT712573 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT715046 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT718905 GALR1 galanin receptor 1 2 2
MIRT719368 FEM1A fem-1 homolog A 2 2
MIRT719495 SEC24B SEC24 homolog B, COPII coat complex component 2 2
MIRT719601 PRKX protein kinase, X-linked 2 2
MIRT719891 RRP36 ribosomal RNA processing 36 2 2
MIRT720063 ZNF449 zinc finger protein 449 2 2
MIRT721679 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT721724 VTI1A vesicle transport through interaction with t-SNAREs 1A 2 2
MIRT723370 ZNF470 zinc finger protein 470 2 2
MIRT724941 TXNL1 thioredoxin like 1 2 2
MIRT725302 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-452 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-452 Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-452 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 down-regulated
miR-452 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-mir-452 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-452 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-452-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-452-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-452-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (HCT8)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-452-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-452-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-452-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

Error report submission