pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SAMD1   
Synonyms -
Description sterile alpha motif domain containing 1
Transcript NM_138352   
Expression
Putative miRNA Targets on SAMD1
3'UTR of SAMD1
(miRNA target sites are highlighted)
>SAMD1|NM_138352|3'UTR
   1 GCGCCCAGCCTCACCCCTGCCCCAGCCCATTCCGGCCCCCATCTCACCCAAGATCCCCCAGAGTCCAGGAGCTGGACGGG
  81 GACACCCTCAGCCCTCATAACAGATTCCAAGGAGAGGGCACCCTCTTGTCCTTATCTTTGCCCCTTGTGTCTGTCTCACA
 161 CACATCTGCTCCTCAGCACGTCGGTGTGGGGAGGGGATTGCTCCTTAAACCCCAGGTGGCTGACCCTCCCCACCCAGTCC
 241 AGGACATTTTAGGAAAAAAAAAATGAAATGTGGGGGGCTTCTCATCTCCCCAAGATCCTCTTCCGTTCAGCCAGATGTTT
 321 CCTGTATAAATGTTTGGATCTGCCTGTTTATTTTGGTGGGTGGTCTTTCCTCCCTCCCCTACCACCCATGCCCCCCTTCT
 401 CAGTCTGCCCCTGGCCTCCAGCCCCTAGGGGACTAGCTGGGTTGGGGTTCCTCGGGCCTTTTCTCTCCTCCCTCTTTTCT
 481 TTCTGTTGATTGTCGCTCCAGCTGGCTGTATTGCTTTTTAATATTGCACCGAAGGTTTTTTAAATAAAATTTTAAAAAAA
 561 GAAAAAGGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' cggUUCCCUUACCGUCCCUUUa 5'
             |||  ||    ||||||| 
Target 5' aaaAAGAAAA----AGGGAAAa 3'
556 - 573 145.00 -10.60
2
miRNA  3' cgGUUCCCUUACCGUCCCUUUa 5'
            | |||  ||  :||| ||| 
Target 5' gtCCAGGACATTTTAGGAAAAa 3'
237 - 258 124.00 -8.00
3
miRNA  3' cgGUUC--CCUUA-CCGUCCCUUua 5'
            || |  || :| || ||||:|  
Target 5' agCACGTCGGTGTGGGGAGGGGAtt 3'
175 - 199 118.00 -17.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31612889 2 COSMIC
COSN22511704 40 COSMIC
COSN19516662 121 COSMIC
COSN9846214 478 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs371601376 1 dbSNP
rs554288887 2 dbSNP
rs972609391 3 dbSNP
rs368172558 6 dbSNP
rs1177978867 12 dbSNP
rs760029685 13 dbSNP
rs1470557794 14 dbSNP
rs759922823 15 dbSNP
rs777263210 16 dbSNP
rs766897901 17 dbSNP
rs761088812 19 dbSNP
rs1357087112 21 dbSNP
rs1012990982 22 dbSNP
rs1317425396 23 dbSNP
rs1246907779 24 dbSNP
rs1289647961 24 dbSNP
rs773598369 26 dbSNP
rs373633546 33 dbSNP
rs748270372 34 dbSNP
rs1386281720 37 dbSNP
rs774226210 38 dbSNP
rs985300614 39 dbSNP
rs768771420 40 dbSNP
rs1424760010 41 dbSNP
rs1398220761 42 dbSNP
rs954028612 43 dbSNP
rs1170844422 44 dbSNP
rs1367773170 47 dbSNP
rs749275281 50 dbSNP
rs1056964152 53 dbSNP
rs571577957 55 dbSNP
rs1238672064 56 dbSNP
rs1201287160 57 dbSNP
rs998775784 59 dbSNP
rs1000575034 60 dbSNP
rs1322248912 62 dbSNP
rs1261777637 63 dbSNP
rs749251903 68 dbSNP
rs902154319 77 dbSNP
rs1020569534 79 dbSNP
rs1042973693 82 dbSNP
rs1414252358 82 dbSNP
rs556299243 86 dbSNP
rs767399039 87 dbSNP
rs896051026 89 dbSNP
rs534528674 90 dbSNP
rs1437155398 92 dbSNP
rs1276520420 93 dbSNP
rs1365299133 94 dbSNP
rs1315817190 97 dbSNP
rs899480510 98 dbSNP
rs1355436705 106 dbSNP
rs937494903 108 dbSNP
rs906042360 115 dbSNP
rs1039458353 116 dbSNP
rs778835287 119 dbSNP
rs1284741285 121 dbSNP
rs538511045 122 dbSNP
rs77876260 123 dbSNP
rs1245477270 125 dbSNP
rs1477947848 130 dbSNP
rs1451954402 131 dbSNP
rs1179665144 133 dbSNP
rs774374695 136 dbSNP
rs1438097246 140 dbSNP
rs1158239638 141 dbSNP
rs1401132001 142 dbSNP
rs918706489 143 dbSNP
rs972712630 144 dbSNP
rs1464317370 145 dbSNP
rs1348064059 149 dbSNP
rs1435614701 151 dbSNP
rs1331828755 155 dbSNP
rs146866735 156 dbSNP
rs368057826 158 dbSNP
rs912454758 160 dbSNP
rs973659467 161 dbSNP
rs963736815 163 dbSNP
rs1287053935 165 dbSNP
rs1426055934 165 dbSNP
rs114933503 166 dbSNP
rs749359492 171 dbSNP
rs1460435060 172 dbSNP
rs1032144002 174 dbSNP
rs1473865532 175 dbSNP
rs1161559087 178 dbSNP
rs1413117247 179 dbSNP
rs991591114 180 dbSNP
rs960073928 183 dbSNP
rs1444308059 191 dbSNP
rs1035533170 195 dbSNP
rs1238315700 196 dbSNP
rs1281952985 199 dbSNP
rs1354998984 201 dbSNP
rs1219833967 210 dbSNP
rs1200131599 211 dbSNP
rs1316513580 212 dbSNP
rs1198423996 218 dbSNP
rs1479476164 219 dbSNP
rs547420353 223 dbSNP
rs781134772 224 dbSNP
rs998724886 225 dbSNP
rs1237028824 228 dbSNP
rs1478183578 230 dbSNP
rs757201802 237 dbSNP
rs1323315857 245 dbSNP
rs1310406744 246 dbSNP
rs1245168474 249 dbSNP
rs1343049680 252 dbSNP
rs1020684122 254 dbSNP
rs1415858828 259 dbSNP
rs1331762518 261 dbSNP
rs1011480638 264 dbSNP
rs1021985231 264 dbSNP
rs1039304899 264 dbSNP
rs761964626 264 dbSNP
rs1218520933 270 dbSNP
rs111468174 271 dbSNP
rs532115179 273 dbSNP
rs890909224 274 dbSNP
rs896152598 275 dbSNP
rs1035921828 283 dbSNP
rs1459736152 286 dbSNP
rs751291762 289 dbSNP
rs1261056324 290 dbSNP
rs1476816136 291 dbSNP
rs919418142 295 dbSNP
rs1163486019 297 dbSNP
rs143904567 300 dbSNP
rs1374479932 303 dbSNP
rs905995464 304 dbSNP
rs1299532495 305 dbSNP
rs1048583219 307 dbSNP
rs1358037606 312 dbSNP
rs942272456 314 dbSNP
rs915918578 317 dbSNP
rs140011003 322 dbSNP
rs1416812792 323 dbSNP
rs531488222 326 dbSNP
rs1274566919 327 dbSNP
rs560892408 332 dbSNP
rs931506560 342 dbSNP
rs960022573 352 dbSNP
rs1487992644 356 dbSNP
rs556567153 360 dbSNP
rs181603962 365 dbSNP
rs571863145 369 dbSNP
rs1221651001 372 dbSNP
rs1394208342 374 dbSNP
rs1439962533 375 dbSNP
rs1037133896 376 dbSNP
rs944030898 378 dbSNP
rs1452420970 379 dbSNP
rs967646429 386 dbSNP
rs1393528910 388 dbSNP
rs912558698 391 dbSNP
rs1021431137 392 dbSNP
rs1011909859 393 dbSNP
rs1236915174 394 dbSNP
rs899725210 395 dbSNP
rs1353164107 397 dbSNP
rs1335283069 399 dbSNP
rs763946532 401 dbSNP
rs1245618717 413 dbSNP
rs1267240492 415 dbSNP
rs932554389 416 dbSNP
rs1018139563 419 dbSNP
rs1207955063 421 dbSNP
rs1007887452 422 dbSNP
rs553695291 428 dbSNP
rs1458034624 431 dbSNP
rs1180193900 448 dbSNP
rs979216265 451 dbSNP
rs1388799464 453 dbSNP
rs545451204 454 dbSNP
rs890771349 455 dbSNP
rs1365917655 456 dbSNP
rs966545415 457 dbSNP
rs1456878806 463 dbSNP
rs1420816079 464 dbSNP
rs867807853 465 dbSNP
rs913624875 467 dbSNP
rs578049829 468 dbSNP
rs556497094 470 dbSNP
rs960362269 471 dbSNP
rs1372890274 478 dbSNP
rs1450913918 480 dbSNP
rs1396775432 483 dbSNP
rs1314989723 485 dbSNP
rs1319978495 491 dbSNP
rs1033770728 494 dbSNP
rs1272465437 495 dbSNP
rs1318425095 496 dbSNP
rs1001908965 498 dbSNP
rs190407977 499 dbSNP
rs1027271364 501 dbSNP
rs1255860535 502 dbSNP
rs1480122104 504 dbSNP
rs1182056236 505 dbSNP
rs531773673 506 dbSNP
rs942286889 507 dbSNP
rs556139329 520 dbSNP
rs916201893 524 dbSNP
rs1056058105 526 dbSNP
rs938688148 527 dbSNP
rs1169013608 528 dbSNP
rs1354279657 530 dbSNP
rs534496627 534 dbSNP
rs1288030348 535 dbSNP
rs1377151621 536 dbSNP
rs1414249389 542 dbSNP
rs1278856189 543 dbSNP
rs977923597 544 dbSNP
rs1349978425 548 dbSNP
rs146065270 552 dbSNP
rs1293231963 553 dbSNP
rs1008736962 554 dbSNP
rs1210460481 560 dbSNP
rs1209547874 561 dbSNP
rs1257393494 561 dbSNP
rs1482033748 561 dbSNP
rs1235650450 562 dbSNP
rs990032135 562 dbSNP
rs1018170706 567 dbSNP
rs767094513 567 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' cgguucccuuaccgUCCCUUUa 5'
                        ||||||| 
Target 5' ----------aaaaAGGGAAAa 3'
1 - 12
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000533683.2 | 3UTR | AAAAAGGGAAAAAAAAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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